keyword
MENU ▼
Read by QxMD icon Read
search

Implementation

keyword
https://www.readbyqxmd.com/read/29353436/biomarker-driven-therapy-in-metastatic-gastric-and-esophageal-cancer-real-life-clinical-experience
#1
Ofer Purim, Alexander Beny, Moshe Inbar, Katerina Shulman, Baruch Brenner, Elizabeth Dudnik, Felix Bokstein, Mark Temper, Dror Limon, Diana Matceyevsky, David Sarid, Amiel Segal, Valeriya Semenisty, Ronen Brenner, Tamar Peretz, Efraim Idelevich, Sharon Pelles-Avraham, Amichay Meirovitz, Arie Figer, Kenneth Russell, Andreas Voss, Addie Dvir, Lior Soussan-Gutman, Ayala Hubert
BACKGROUND: Precision treatment of cancer uses biomarker-driven therapy to individualize and optimize patient care. OBJECTIVE: To evaluate real-life clinical experience with biomarker-driven therapy in metastatic gastric and esophageal cancer in Israel. PATIENTS AND METHODS: This multicenter retrospective cohort study included patients with metastatic gastric or esophageal cancer who were treated in the participating institutions and underwent biomarker-driven therapy...
January 20, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/29353430/multiplex-highly-sensitive-immunochromatographic-assay-based-on-the-use-of-nonprocessed-antisera
#2
Nadezhda A Byzova, Alexandr E Urusov, Anatoly V Zherdev, Boris B Dzantiev
The format of an immunochromatographic multiassay is first proposed with native antisera and a universal conjugate of antispecies antibodies with gold nanoparticles. This format allows (1) the exclusion of purification and conjugation stages for specific antibodies and (2) significant reduction of the concentration of specific antibodies in the system. The independent use of specific antibodies and a conjugated marker provided a low detection limit and high signal intensity. The proposed format was implemented for the simultaneous detection of two herbicides...
January 20, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29353308/single-stage-autotrophic-nitrogen-removal-process-at-high-loading-rate-granular-reactor-performance-kinetics-and-microbial-characterization
#3
Feiyue Qian, Abebe Temesgen Gebreyesus, Jianfang Wang, Yaoliang Shen, Wenru Liu, Lulin Xie
For the possible highest performance of single-stage combined partial nitritation/anammox (PNA) process, a continuous complete-mix granular reactor was operated at progressively higher nitrogen loading rate. The variations in bacterial community structure of granules were also characterized using high-throughput pyrosequencing, to give a detail insight to the relationship between reactor performance and functional organism abundance within completely autotrophic nitrogen removal system. In 172 days of operation, a superior total nitrogen (TN) removal rate over 3...
January 20, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29353277/a-critical-review-of-the-consensus-statement-from-the-european-atherosclerosis-society-consensus-panel-2017
#4
Harumi Okuyama, Tomohito Hamazaki, Rokuro Hama, Yoichi Ogushi, Tetsuyuki Kobayashi, Naoki Ohara, Hajime Uchino
BACKGROUND: The Consensus Statement from the European Atherosclerosis Society (EAS) Consensus Panel 2017 concludes on the basis of 3 different types of clinical studies that low-density lipoprotein (LDL) causes atherosclerotic cardiovascular disease (ASCVD). In Mendelian randomization studies, rare genetic mutations affecting LDL receptor function were found to cause higher or lower LDL-C levels, which are associated with correspondingly altered ASCVD risk. In prospective cohort studies and randomized controlled trials (RCTs) of statins, a remarkably consistent log-linear association was demonstrated between the absolute magnitude of LDL-C exposure and ASCVD risk...
January 19, 2018: Pharmacology
https://www.readbyqxmd.com/read/29353266/twenty-seven-mutations-with-three-novel-pathologenic-variants-causing-biotinidase-deficiency-a-report-of-203-patients-from-the-southeastern-part-of-turkey
#5
Berna Seker Yilmaz, Neslihan Onenli Mungan, Deniz Kor, Derya Bulut, Gülşah Seydaoglu, Murat Öktem, Serdar Ceylaner
BACKGROUND: Biotinidase deficiency (BD) is an autosomal recessive inborn error of metabolism characterized by neurologic and cutaneous symptoms and can be detected by newborn screening. Newborn screening for BD was implemented in Turkey at the end of 2008. METHODS: In total, 203 patients who were identified among the infants detected by the newborn screening were later confirmed to have BD through measurement of serum biotinidase activity. We also performed BTD mutation analysis to characterize the genetic profile...
January 20, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29353257/ethical-dilemmas-of-recording-and-reviewing-neonatal-resuscitation
#6
REVIEW
Maria C den Boer, Mirjam Houtlosser, Henriëtte Anje van Zanten, Elizabeth E Foglia, Dirk P Engberts, Arjan B Te Pas
Neonatal resuscitation is provided to approximately 3% of neonates. Adequate ventilation is often the key to successful resuscitation, but this can be difficult to provide. There is increasing evidence that inappropriate respiratory support can have severe consequences. Several neonatal intensive care units have recorded and reviewed neonatal resuscitation procedures for quality assessment, education and research; however, ethical dilemmas sometimes make it difficult to implement this review process. We reviewed the literature on the development of recording and reviewing neonatal resuscitation and have summarised the ethical concerns involved...
January 20, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29353251/cardiopulmonary-resuscitation-the-science-behind-the-hands
#7
REVIEW
Andrew W Harris, Peter J Kudenchuk
Sudden cardiac arrest is a leading cause of death worldwide. Despite significant advances in resuscitation science since the initial use of external chest compressions in humans nearly 60 years ago, there continues to be wide variability in rates of successful resuscitation across communities. The American Heart Association (AHA) and European Resuscitation Council emphasise the importance of high-quality chest compressions as the foundation of resuscitation care. We review the physiological basis for the association between chest compression quality and clinical outcomes and the scientific basis for the AHA's key metrics for high-quality cardiopulmonary resuscitation...
January 20, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29353246/a-concept-mapping-approach-to-identifying-the-barriers-to-implementing-an-evidence-based-sports-injury-prevention-programme
#8
Alex Donaldson, Aisling Callaghan, Mario Bizzini, Andrew Jowett, Patrick Keyzer, Matthew Nicholson
BACKGROUND AND AIM: Understanding the barriers to programme use is important to facilitate implementation of injury prevention programmes in real-word settings. This study investigated the barriers to coaches of adolescent female soccer teams, in Victoria, Australia, implementing the evidence-based FIFA 11+ injury prevention programme. METHODS: Concept mapping with data collected from 19 soccer coaches and administrators. RESULTS: Brainstorming generated 65 statements as barriers to 11+ implementation...
January 20, 2018: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29353183/automatic-bad-channel-detection-in-intracranial-electroencephalographic-recordings-using-ensemble-machine-learning
#9
Viateur Tuyisenge, Lena Trebaul, Manik Bhattacharjee, Blandine Chanteloup-Forêt, Carole Saubat-Guigui, Ioana Mîndruţă, Sylvain Rheims, Louis Maillard, Philippe Kahane, Delphine Taussig, Olivier David
OBJECTIVE: Intracranial electroencephalographic (iEEG) recordings contain "bad channels", which show non-neuronal signals. Here, we developed a new method that automatically detects iEEG bad channels using machine learning of seven signal features. METHODS: The features quantified signals' variance, spatial-temporal correlation and nonlinear properties. Because the number of bad channels is usually much lower than the number of good channels, we implemented an ensemble bagging classifier known to be optimal in terms of stability and predictive accuracy for datasets with imbalanced class distributions...
December 24, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29353132/supporting-parents-through-stillbirth-a-qualitative-study-exploring-the-views-of-health-professionals-and-health-care-staff-in-three-hospitals-in-england
#10
Lyn Brierley-Jones, Rosalind Crawley, Emma Jones, Isabel Gordon, Joanne Knight, Kim Hinshaw
OBJECTIVE: To investigate the views of a range of hospital based health professionals and health care staff involved in the management of stillbirth. STUDY DESIGN: A qualitative pilot study informed by grounded theory conducted in three hospital trusts in the North East of England. In total, 21 consultant obstetricians, 3 trainees (including 1 senior trainee), 29 midwives, 3 midwife sonographers and 4 chaplains took part in six focus groups and two semi-structured interviews...
January 9, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29353128/adoption-penetration-and-effectiveness-of-a-secondary-risk-screener-for-intimate-partner-violence-evidence-to-inform-screening-practices-in-integrated-care-settings
#11
Katherine M Iverson, Anneliese E Sorrentino, Scarlett L Bellamy, Alessandra R Grillo, Terri N Haywood, Elina Medvedeva, Christopher B Roberts, Melissa E Dichter
OBJECTIVE: Veterans Health Administration (VHA) has implemented screening for past-year intimate partner violence (IPV) in some healthcare facilities along with secondary screening of risk for severe violence among those screening positive in order to facilitate follow-up care for high-risk patients. We evaluated the adoption, penetration, and effectiveness of secondary screening as a tool to facilitate timely follow-up services. METHODS: Retrospective review of medical records (screening and healthcare use) of 774 women screening positive for past-year IPV (IPV+) at 11 facilities nationwide from April 2014-April 2016...
January 10, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29353094/effects-of-scaling-task-constraints-on-emergent-behaviours-in-children-s-racquet-sports-performance
#12
Anna Fitzpatrick, Keith Davids, Joseph A Stone
Manipulating task constraints by scaling key features like space and equipment is considered an effective method for enhancing performance development and refining movement patterns in sport. Despite this, it is currently unclear whether scaled manipulation of task constraints would impact emergent movement behaviours in young children, affording learners opportunities to develop relevant skills. Here, we sought to investigate how scaling task constraints during 8 weeks of mini tennis training shaped backhand stroke development...
January 17, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29353089/influence-of-perceptions-and-stereotypes-of-the-nursing-role-on-career-choice-in-secondary-students-a-regional-perspective
#13
Anita Raymond, Ainsley James, Elisabeth Jacob, Judith Lyons
BACKGROUND: This study examined the influence that perceptions and stereotypes of the nursing role had on future career choice of rural secondary students. OBJECTIVE: The study was undertaken to identify a method of attracting final year secondary school students to an undergraduate nursing degree at a rural University. DESIGN: A mixed method study using a pre-post-interventional design. SETTING: The rural campus of an Australian university...
December 29, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29353034/impact-of-targeted-scanning-protocols-on-perinatal-outcomes-in-pregnancies-at-risk-of-placenta-accreta-spectrum-or-vasa-previa
#14
Yaakov Melcer, Eric Jauniaux, Shlomit Maymon, Anna Tsviban, Marina Pekar-Zlotin, Moshe Betser, Ron Maymon
BACKGROUND: Placenta accreta spectrum (PAS) and vasa previa (VP) are congenital disorders of placentation associated with high morbidity and mortality for both mothers and newborns when undiagnosed before delivery. Prenatal diagnosis of these conditions is essential to allow multidisciplinary management and thus improve perinatal outcomes. OBJECTIVES: To compare perinatal outcome in women with PAS or VP before and after implementation of targeted scanning protocols...
January 15, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29352836/implementation-of-the-integrated-palliative-care-outcome-scale-in-acute-care-settings-a-feasibility-study
#15
Susanne Lind, J Sandberg, T Brytting, C J Fürst, L Wallin
OBJECTIVE: Although hospitals have been described as inadequate place for end-of-life care, many deaths still occur in hospital settings. Although patient-reported outcome measures have shown positive effects for patients in need of palliative care, little is known about how to implement them. We aimed to explore the feasibility of a pilot version of an implementation strategy for the Integrated Palliative care Outcome Scale (IPOS) in acute care settings. METHOD: A strategy, including information, training, and facilitation to support the use of IPOS, was developed and carried out at three acute care units...
January 21, 2018: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29352824/evaluating-the-effect-of-a-clostridium-difficile-infection-prevention-initiative-in-veterans-health-administration-long-term-care-facilities
#16
Maninder B Singh, Martin E Evans, Loretta A Simbartl, Stephen M Kralovic, Gary A Roselle
We evaluated rates of clinically confirmed long-term-care facility-onset Clostridium difficile infections from April 2014 through December 2016 in 132 Veterans Affairs facilities after the implementation of a prevention initiative. The quarterly pooled rate decreased 36.1% from the baseline (P<.0009 for trend) by the end of the analysis period. Infect Control Hosp Epidemiol 2018;1-3.
January 21, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29352817/the-association-between-sexual-behaviours-and-initiation-of-post-secondary-education-in-south-africa
#17
Annah V Bengesai, Hafiz T A Khan, Russell Dube
Although young people in South Africa are growing up in an era where their socioeconomic circumstances are seemingly better than those of their parents' generation, they face greater risks in their trajectory to adulthood. This is mainly because the environment in which they are making sexual decisions is also rapidly evolving. Currently, South Africa has the highest prevalence of HIV and AIDS in the world among young people aged 15-24. This study examined the effect of sexual behaviours initiated in adolescence on enrolment in post-secondary education...
January 21, 2018: Journal of Biosocial Science
https://www.readbyqxmd.com/read/29352813/age-at-menarche-and-sexual-debut-among-young-filipino-women
#18
Nai-Peng Tey, Siow-Li Lai, Sor-Tho Ng
There has been a secular decline in age at menarche since the 19th century. Early-maturing women are more likely to have their sexual debut at a younger age, which in turn gives rise to a host of reproductive health and social problems. This study used data from five waves of National Demographic and Health Surveys conducted in the Philippines between 1993 and 2013 to examine the trends and socioeconomic differentials in age at menarche and sexual debut. The changing trend in age at menarche and sexual debut was examined across birth cohorts, and logistic regressions were used to identify the determinants of early sexual debut...
January 21, 2018: Journal of Biosocial Science
https://www.readbyqxmd.com/read/29352798/two-component-relativistic-coupled-cluster-methods-using-mean-field-spin-orbit-integrals
#19
Junzi Liu, Yue Shen, Ayush Asthana, Lan Cheng
A novel implementation of the two-component spin-orbit (SO) coupled-cluster singles and doubles (CCSD) method and the CCSD augmented with the perturbative inclusion of triple excitations [CCSD(T)] method using mean-field SO integrals is reported. The new formulation of SO-CCSD(T) features an atomic-orbital-based algorithm for the particle-particle ladder term in the CCSD equation, which not only removes the computational bottleneck associated with the large molecular-orbital integral file but also accelerates the evaluation of the particle-particle ladder term by around a factor of 4 by taking advantage of the spin-free nature of the instantaneous electron-electron Coulomb interaction...
January 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29352790/on-the-theoretical-prediction-of-fluorescence-rates-from-first-principles-using-the-path-integral-approach
#20
Bernardo de Souza, Frank Neese, Róbert Izsák
In this work, we present and implement the theory for calculating fluorescence rates and absorption and emission spectra from first principles, using the path integral approach. We discuss some approximations and modifications to the full set of equations that improve speed and numerical stability for the case when a large number of modes are considered. New methods to approximate the excited state potential energy surface are also discussed and it is shown that for most purposes, these can be used instead of a full geometry optimization to obtain the rates mentioned above...
January 21, 2018: Journal of Chemical Physics
keyword
keyword
38240
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"