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https://www.readbyqxmd.com/read/28281877/comprehensive-analysis-of-interaction-networks-of-telomerase-reverse-transcriptase-with-multiple-bioinformatic-approach-deep-mining-the-potential-functions-of-telomere-and-telomerase
#1
Chunyu Hou, Fei Wang, Xuewen Liu, Guangming Chang, Feng Wang, Xin Geng
Telomerase reverse transcriptase (TERT)is the protein component of telomerase complex. Evidence has accumulated showing that the non-telomeric functions of TERT are independent of telomere elongation. However, the mechanisms governing the interaction between TERT and its target genes are not revealed clear. The biological functions of TERT are not fully elucidated and have thus far been underestimated. To further explore these functions, we investigated TERT interaction networks using multiple bioinformatic databases, including BioGRID, STRING, DAVID, GeneCards, GeneMANIA, PANTHER, miRWalk, mirTarBase, miRNet, miRDB and TargetScan...
March 6, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28273071/ethnic-groups-knowledge-attitude-and-practices-and-rift-valley-fever-exposure-in-isiolo-county-of-kenya
#2
Hippolyte Affognon, Peter Mburu, Osama Ahmed Hassan, Sarah Kingori, Clas Ahlm, Rosemary Sang, Magnus Evander
Rift Valley fever (RVF) is an emerging mosquito-borne viral hemorrhagic fever in Africa and the Arabian Peninsula, affecting humans and livestock. For spread of infectious diseases, including RVF, knowledge, attitude and practices play an important role, and the understanding of the influence of behavior is crucial to improve prevention and control efforts. The objective of the study was to assess RVF exposure, in a multiethnic region in Kenya known to experience RVF outbreaks, from the behavior perspective...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28240033/seroprevalence-of-rift-valley-fever-in-cattle-along-the-akagera-nyabarongo-rivers-rwanda
#3
Thérèse Umuhoza, Dirk Berkvens, Isidore Gafarasi, Joseph Rukelibuga, Borden Mushonga, Savino Biryomumaisho
Rift Valley fever (RVF) virus is caused by a zoonotic arbovirus that is endemic to eastern and southern Africa. It has also been reported in West and North Africa, Madagascar and the Arabian Peninsula. The virus is transmitted by mosquitoes, but people can also become infected while handling blood or other body fluids of animals and humans with RVF. In 2007, there was a large outbreak of RVF in Kenya, Tanzania, Sudan and Somalia. Outbreaks were also reported in South Africa in 2008-2011. The epidemiology of RVF and factors for disease occurrence in Rwanda are neither clear nor documented...
January 20, 2017: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/28212379/distribution-and-abundance-of-key-vectors-of-rift-valley-fever-and-other-arboviruses-in-two-ecologically-distinct-counties-in-kenya
#4
Rosemary Sang, Samwel Arum, Edith Chepkorir, Gladys Mosomtai, Caroline Tigoi, Faith Sigei, Olivia Wesula Lwande, Tobias Landmann, Hippolyte Affognon, Clas Ahlm, Magnus Evander
BACKGROUND: Rift Valley fever (RVF) is a mosquito-borne viral zoonosis of ruminants and humans that causes outbreaks in Africa and the Arabian Peninsula with significant public health and economic consequences. Humans become infected through mosquito bites and contact with infected livestock. The virus is maintained between outbreaks through vertically infected eggs of the primary vectors of Aedes species which emerge following rains with extensive flooding. Infected female mosquitoes initiate transmission among nearby animals, which amplifies virus, thereby infecting more mosquitoes and moving the virus beyond the initial point of emergence...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28207905/the-one-health-approach-to-identify-knowledge-attitudes-and-practices-that-affect-community-involvement-in-the-control-of-rift-valley-fever-outbreaks
#5
Osama Ahmed Hassan, Hippolyte Affognon, Joacim Rocklöv, Peter Mburu, Rosemary Sang, Clas Ahlm, Magnus Evander
Rift Valley fever (RVF) is a viral mosquito-borne disease with the potential for global expansion, causes hemorrhagic fever, and has a high case fatality rate in young animals and in humans. Using a cross-sectional community-based study design, we investigated the knowledge, attitudes and practices of people living in small village in Sudan with respect to RVF outbreaks. A special One Health questionnaire was developed to compile data from 235 heads of household concerning their knowledge, attitudes, and practices with regard to controlling RVF...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28202077/repellent-effects-of-the-essential-oils-of-cymbopogon-citratus-and-tagetes-minuta-on-the-sandfly-phlebotomus-duboscqi
#6
Albert Kimutai, Moses Ngeiywa, Margaret Mulaa, Peter G N Njagi, Johnstone Ingonga, Lydia B Nyamwamu, Cyprian Ombati, Philip Ngumbi
BACKGROUND: The sandfly, Phlebotomus duboscqi is a vector of zoonotic cutaneous leishmaniasis (ZCL) that is an important public health problem in Eastern Africa. Repellents have been used for protection of humans against vectors of ZCL and other vectors that transmit killer diseases including malaria, Rift Valley fever, dengue, and yellow fever. The repellent effects of different doses of the essential oils from the lemon grass, Cymbopogon citratus and Mexican marigold, Tagetes minuta were evaluated in a two-chamber bioassay against 3- to 7-day-old unfed females of P...
February 15, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28191786/quantifying-the-potential-pathways-and-locations-of-rift-valley-fever-virus-entry-into-the-united-states
#7
A J Golnar, R C Kading, G L Hamer
The global invasion of West Nile virus, chikungunya virus and Zika virus in the past two decades suggests an increasing rate of mosquito-borne virus (arbovirus) dispersal. Rift Valley fever virus (RVFV) is an arbovirus identified as a high-consequence threat to the United States (USA) because of the severe economic and health consequences associated with disease. Numerous studies demonstrate that the USA is receptive to RVFV transmission based on the widespread presence of competent mosquito species and vertebrate species...
February 12, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28179007/global-research-trends-of-world-health-organization-s-top-eight-emerging-pathogens
#8
Waleed M Sweileh
BACKGROUND: On December 8(th), 2015, World Health Organization published a priority list of eight pathogens expected to cause severe outbreaks in the near future. To better understand global research trends and characteristics of publications on these emerging pathogens, we carried out this bibliometric study hoping to contribute to global awareness and preparedness toward this topic. METHOD: Scopus database was searched for the following pathogens/infectious diseases: Ebola, Marburg, Lassa, Rift valley, Crimean-Congo, Nipah, Middle Eastern Respiratory Syndrome (MERS), and Severe Respiratory Acute Syndrome (SARS)...
February 8, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28166146/bone-scan-pet-ct-and-mri-in-disseminated-coccidioidomycosis
#9
John Randolph Dryden, Michael David Starsiak, Mickaila James Johnston, Eugene David Silverman
Coccidioidomycosis (valley fever) is a systemic fungal infection resulting from inhalation of the Coccidioides immitis or posadasii spores. In many cases, infection causes a self-limited community-acquired pneumonia; however, in patients with risk factors, such as immunosuppression or African or Pacific Island ancestry, significant morbidity and mortality from disseminated disease may occur. Presented here are comparative images using Tc-MDP bone scan, F-FDG PET/CT, and MRI. Each demonstrates particular strengths, which aid in assessing the extent of systemic involvement of a biopsy-proven case of disseminated coccidioidomycosis...
February 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28162129/assessment-of-community-awareness-and-risk-perceptions-of-zoonotic-causes-of-abortion-in-cattle-at-three-selected-livestock-wildlife-interface-areas-of-zimbabwe
#10
M Ndengu, M DE Garine-Wichatitsky, D M Pfukenyi, M Tivapasi, B Mukamuri, G Matope
A study was conducted to assess the awareness of cattle abortions due to brucellosis, Rift Valley fever (RVF) and leptospirosis, and to compare frequencies of reported abortions in communities living at the periphery of the Great Limpopo Transfrontier Conservation Area in southeastern Zimbabwe. Three study sites were selected based on the type of livestock-wildlife interface: porous livestock-wildlife interface (unrestricted); non-porous livestock-wildlife interface (restricted by fencing); and livestock-wildlife non-interface (totally absent or control)...
February 6, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28153792/mosquito-borne-viruses-circulating-in-kinshasa-democratic-republic-of-the-congo
#11
Kennedy Makola Mbanzulu, Roger Wumba, Jean-Pierre Kambala Mukendi, Josué Kikana Zanga, Fortunate Shija, Thierry Lengu Bobanga, Michel Ntetani Aloni, Gerald Misinzo
BACKGROUND: Diseases caused by mosquito-borne viruses are among the most important emerging diseases that threaten human and animal health, particularly in Africa. However, little attention has been paid to these diseases in the Democratic Republic of the Congo (DRC). The present cross-sectional study was undertaken between March and May 2014 to investigate the presence of mosquito-borne viruses in mosquitoes collected from five municipalities of Kinshasa, DRC. METHODS: Mosquitoes were collected using BG-Sentinel traps and battery-powered aspirators...
January 30, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28141497/characterization-of-the-bujaru-frijoles-and-tapara-antigenic-complexes-into-the-sandfly-fever-group-and-two-unclassified-phleboviruses-from-brazil
#12
Pedro F C Vasconcelos, Joaquim Pinto Nunes Neto, William Marciel de Souza, Gustavo Olszanski Acrani, Marilia Farignoli Romeiro, Marcílio Jorge Fumagalli, Carlos Luiz Vieira, Daniele Barbosa de Almeida Medeiros, Juliana Abreu de Lima, Clayton Pereira Silva de Lima, Jedson Ferreira Cardoso, Sueli Guerreiro Rodrigues, Luiz Tadeu de Moraes Figueiredo, Sandro Patroca da Silva, Robert Tesh, Márcio Roberto Teixeira Nunes, Pedro Fernando da Costa Vasconcelos
Phlebovirus genus includes the Sandfly fever viruses and tick-transmitted uukuviruses. Sandfly fever group viruses have been isolated from various vertebrate species and from phlebotomines and occasionally alternative arthropods, e.g. mosquitoes, or ceratopogonids in the genus Culicoides. Uukuniemi serogroup viruses have been isolated from various vertebrate species and from ticks. Despite the public health importance of some viruses of the genus, the genomic diversity of phleboviruses that could be incriminated as causative of human or veterinary diseases remains underestimated...
January 28, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28126462/exploring-genetic-variation-in-haplotypes-of-the-filariasis-vector-culex-quinquefasciatus-diptera-culicidae-through-dna-barcoding
#13
Chithravel Vadivalagan, Pushparaj Karthika, Kadarkarai Murugan, Chellasamy Panneerselvam, Paola Del Serrone, Giovanni Benelli
Culex quinquefasciatus (Diptera: Culicidae) is a vector of many pathogens and parasites of humans, as well as domestic and wild animals. In urban and semi-urban Asian countries, Cx. quinquefasciatus is a main vector of nematodes causing lymphatic filariasis. In the African region, it vectors the Rift Valley fever virus, while in the USA it transmits West Nile, St. Louis encephalitis and Western equine encephalitis virus. In this study, DNA barcoding was used to explore the genetic variation of Cx. quinquefasciatus populations from 88 geographical regions...
May 2017: Acta Tropica
https://www.readbyqxmd.com/read/28125594/correction-modelling-vaccination-strategies-against-rift-valley-fever-in-livestock-in-kenya
#14
John M Gachohi, M Kariuki Njenga, Philip Kitala, Bernard Bett
[This corrects the article DOI: 10.1371/journal.pntd.0005049.].
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28118988/evaluation-of-positive-rift-valley-fever-virus-formalin-fixed-paraffin-embedded-samples-as-a-source-of-sequence-data-for-retrospective-phylogenetic-analysis
#15
B Mubemba, P N Thompson, L Odendaal, P Coetzee, E H Venter
Rift Valley fever (RVF), caused by an arthropod borne Phlebovirus in the family Bunyaviridae, is a haemorrhagic disease that affects ruminants and humans. Due to the zoonotic nature of the virus, a biosafety level 3 laboratory is required for isolation of the virus. Fresh and frozen samples are the preferred sample type for isolation and acquisition of sequence data. However, these samples are scarce in addition to posing a health risk to laboratory personnel. Archived formalin-fixed, paraffin-embedded (FFPE) tissue samples are safe and readily available, however FFPE derived RNA is in most cases degraded and cross-linked in peptide bonds and it is unknown whether the sample type would be suitable as reference material for retrospective phylogenetic studies...
May 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28116860/rift-valley-fever-virus-infections-in-egyptian-cattle-and-their-prevention
#16
C Mroz, M Gwida, M El-Ashker, U Ziegler, T Homeier-Bachmann, M Eiden, M H Groschup
Rift Valley fever virus (RVFV) causes consistently severe outbreaks with high public health impacts and economic losses in livestock in many African countries and has also been introduced to Saudi Arabia and Yemen. Egypt with its four large outbreaks in the last 40 years represents the northernmost endemic area of RVFV. The purpose of this study was to provide an insight into the current anti-RVFV antibody status in immunized as well as non-immunized dairy cattle from the Nile Delta of Egypt. During 2013-2015, a total of 4,167 dairy cattle from four governorates including Dakahlia, Damietta, Gharbia and Port Said were investigated...
January 24, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28103955/mosquitoes-diptera-culicidae-in-mauritania-a-review-of-their-biodiversity-distribution-and-medical-importance
#17
REVIEW
Aichetou Mint Mohamed Lemine, Mohamed Aly Ould Lemrabott, Moina Hasni Ebou, Khadijetou Mint Lekweiry, Mohamed Salem Ould Ahmedou Salem, Khyarhoum Ould Brahim, Mohamed Ouldabdallahi Moukah, Issa Nabiyoullahi Ould Bouraya, Cecile Brengues, Jean-François Trape, Leonardo Basco, Hervé Bogreau, Frédéric Simard, Ousmane Faye, Ali Ould Mohamed Salem Boukhary
Although mosquitoes (Diptera: Culicidae) are important disease vectors, information on their biodiversity in Mauritania is scarce and very dispersed in the literature. Data from the scientific literature gathered in the country from 1948 to 2016 were collected and analyzed. Overall 51 culicid species comprising 17 Anopheles spp., 14 Aedes spp., 18 Culex spp. and two Mansonia spp. have been described in Mauritania among which Anopheles arabiensis, Aedes vexans, Culex poicilipes and Culex antennatus are of epidemiological significance...
January 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28096531/the-first-imported-case-of-rift-valley-fever-in-china-reveals-a-genetic-reassortment-of-different-viral-lineages
#18
Jingyuan Liu, Yulan Sun, Weifeng Shi, Shuguang Tan, Yang Pan, Shujuan Cui, Qingchao Zhang, Xiangfeng Dou, Yanning Lv, Xinyu Li, Xitai Li, Lijuan Chen, Chuansong Quan, Qianli Wang, Yingze Zhao, Qiang Lv, Wenhao Hua, Hui Zeng, Zhihai Chen, Haofeng Xiong, Chengyu Jiang, Xinghuo Pang, Fujie Zhang, Mifang Liang, Guizhen Wu, George F Gao, William J Liu, Ang Li, Quanyi Wang
We report the first imported case of Rift Valley fever (RVF) in China. The patient returned from Angola, a non-epidemic country, with an infection of a new reassortant from different lineages of Rift Valley fever viruses (RVFVs). The patient developed multiorgan dysfunction and gradually recovered with continuous renal replacement therapy and a short regimen of methylprednisolone treatment. The disordered cytokines and chemokines in the plasma of the patient revealed hypercytokinemia, but the levels of protective cytokines were low upon admission and fluctuated as the disease improved...
January 18, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28096420/drivers-of-rift-valley-fever-epidemics-in-madagascar
#19
Renaud Lancelot, Marina Béral, Vincent Michel Rakotoharinome, Soa-Fy Andriamandimby, Jean-Michel Héraud, Caroline Coste, Andrea Apolloni, Cécile Squarzoni-Diaw, Stéphane de La Rocque, Pierre B H Formenty, Jérémy Bouyer, G R William Wint, Eric Cardinale
Rift Valley fever (RVF) is a vector-borne viral disease widespread in Africa. The primary cycle involves mosquitoes and wild and domestic ruminant hosts. Humans are usually contaminated after contact with infected ruminants. As many environmental, agricultural, epidemiological, and anthropogenic factors are implicated in RVF spread, the multidisciplinary One Health approach was needed to identify the drivers of RVF epidemics in Madagascar. We examined the environmental patterns associated with these epidemics, comparing human and ruminant serological data with environmental and cattle-trade data...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28093537/dengue-epidemic-in-postconflict-swat-district-khyber-pakhtunkhwa-pakistan-2013
#20
Mamoona Chaudhry, Saeed Ahmad, Hamad Bin Rashid, Iftikhar Ud Din
Swat, a lush green valley of 1.3 million persons, remained under militant insurgency from 2007 to 2009, which damaged the health infrastructure. An outbreak of dengue fever (DF) was declared in the valley in 2013. To investigate this outbreak, we established active surveillance of national hospitals and private clinics, reviewed available clinical and laboratory records, and conducted entomological survey. From August to November 2013, 16,000 suspected patients with acute febrile illness were presented to health facilities...
January 16, 2017: American Journal of Tropical Medicine and Hygiene
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