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Valley fever

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https://www.readbyqxmd.com/read/29155823/development-and-preliminary-evaluation-of-a-multiplexed-amplification-and-next-generation-sequencing-method-for-viral-hemorrhagic-fever-diagnostics
#1
Annika Brinkmann, Koray Ergünay, Aleksandar Radonić, Zeliha Kocak Tufan, Cristina Domingo, Andreas Nitsche
BACKGROUND: We describe the development and evaluation of a novel method for targeted amplification and Next Generation Sequencing (NGS)-based identification of viral hemorrhagic fever (VHF) agents and assess the feasibility of this approach in diagnostics. METHODOLOGY: An ultrahigh-multiplex panel was designed with primers to amplify all known variants of VHF-associated viruses and relevant controls. The performance of the panel was evaluated via serially quantified nucleic acids from Yellow fever virus, Rift Valley fever virus, Crimean-Congo hemorrhagic fever (CCHF) virus, Ebola virus, Junin virus and Chikungunya virus in a semiconductor-based sequencing platform...
November 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29130603/proteogenomic-re-annotation-of-coccidioides-posadasii-strain-silveira
#2
Natalie M Mitchell, Andrew L Sherrard, Surendra Dasari, D Mitchell Magee, Thomas E Grys, Douglas F Lake
The aims of this study were to provide protein-based evidence upon which to re-annotate of the genome of C. posadasii, one of two closely related species of Coccidioides, a dimorphic fungal pathogen that causes coccidioidomycosis, also called Valley Fever. Proteins present in lysates and filtrates of in vitro grown mycelia and parasitic phase spherules from C. posadasii strain Silveira were analyzed using a GeLC-MS/MS method. Acquired spectra were processed with a proteogenomics workflow comprising a Silveira proteome database, a 6-frame translation of the Silveira genome and an ab initio gene prediction tool prior to validation against published ESTs...
November 12, 2017: Proteomics
https://www.readbyqxmd.com/read/29128744/comparison-of-two-zoonotic-viruses-from-the-order-bunyavirales
#3
REVIEW
Leela E Noronha, William C Wilson
A comparison of two geographicallly distinct viruses in the order Bunyavirales that are zoonotic and known to cause congenital abnormalities in ruminant livestock was performed. One of these viruses, Cache Valley fever virus, is found in the Americas and is primarily associated with disease in sheep. The other, Rift Valley fever virus, is found in Sub-Saharan Africa and is associated with disease in camels, cattle, goats and sheep. Neither virus has been associated with teratogenicity in humans to date. These two viruses are briefly reviewed and potential for genetic changes especially if introduced into new ecology that could affect pathogenicity are discussed...
November 9, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/29124249/relating-coccidioidomycosis-valley-fever-incidence-to-soil-moisture-conditions
#4
E J Coopersmith, J E Bell, K Benedict, J Shriber, O McCotter, M H Cosh
Coccidioidomycosis (also called Valley fever) is caused by a soilborne fungus, Coccidioides spp., in arid regions of the southwestern United States. Though some who develop infections from this fungus remain asymptomatic, others develop respiratory disease as a consequence. Less commonly, severe illness and death can occur when the infection spreads to other regions of the body. Previous analyses have attempted to connect the incidence of coccidioidomycosis to broadly available climatic measurements, such as precipitation or temperature...
April 17, 2017: Geohealth
https://www.readbyqxmd.com/read/29118186/identification-of-phlebovirus-and-arenavirus-rna-sequences-that-stall-and-repress-the-exoribonuclease-xrn1
#5
Phillida A Charley, Carol J Wilusz, Jeffrey Wilusz
Regulated mRNA decay plays a vital role in determining both the level and quality of cellular gene expression. Viral RNAs must successfully evade this host RNA decay machinery to establish a productive infection. One way for RNA viruses to accomplish this is to target the cellular exoribonuclease XRN1, since this enzyme is accessible in the cytoplasm and plays a major role in mRNA decay. Members of the Flaviviridae use RNA structures in their 5' or 3' untranslated regions to stall and repress XRN1, effectively stabilizing viral RNAs while also causing significant dysregulation of host cell mRNA stability...
November 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29118127/peripheral-blood-biomarkers-of-disease-outcome-in-a-monkey-model-of-rift-valley-fever-encephalitis
#6
Elizabeth R Wonderlich, Amy L Caroline, Cynthia M McMillen, Aaron W Walters, Douglas S Reed, Simon M Barratt-Boyes, Amy L Hartman
Rift Valley Fever (RVF) is an emerging arboviral disease of livestock and people. Although a mosquito-borne virus, humans are infected through contact with or inhalation of virus-laden particles from contaminated animal carcasses. Some individuals infected with RVF virus (RVFV) develop meningoencephalitis resulting in morbidity and mortality. Little is known about the pathogenic mechanisms that lead to neurologic sequelae, and thus animal models that represent human disease are needed. African green monkeys (AGM) exposed to aerosols containing RVFV develop a reproducibly lethal neurological disease that resembles human illness...
November 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29107145/overlapping-cd8-and-cd4-t-cell-epitopes-identification-for-the-progression-of-epitope-based-peptide-vaccine-from-nucleocapsid-and-glycoprotein-of-emerging-rift-valley-fever-virus-using-immunoinformatics-approach
#7
Utpal Kumar Adhikari, M Mizanur Rahman
Rift Valley fever virus (RVFV) is an emergent arthropod-borne zoonotic infectious viral pathogen which causes fatal diseases in the humans and ruminants. Currently, no effective and licensed vaccine is available for the prevention of RVFV infection in endemic as well as in non-endemic regions. So, an immunoinformatics-driven genome-wide screening approach was performed for the identification of overlapping CD8+ and CD4+ T-cell epitopes and also linear B-cell epitopes from the conserved sequences of the nucleocapsid (N) and glycoprotein (G) of RVFV...
October 30, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29097548/a-glycerophospholipid-specific-pocket-in-the-rvfv-class-ii-fusion-protein-drives-target-membrane-insertion
#8
P Guardado-Calvo, K Atkovska, S A Jeffers, N Grau, M Backovic, J Pérez-Vargas, S M de Boer, M A Tortorici, G Pehau-Arnaudet, J Lepault, P England, P J Rottier, B J Bosch, J S Hub, F A Rey
The Rift Valley fever virus (RVFV) is transmitted by infected mosquitoes, causing severe disease in humans and livestock across Africa. We determined the x-ray structure of the RVFV class II fusion protein Gc in its postfusion form and in complex with a glycerophospholipid (GPL) bound in a conserved cavity next to the fusion loop. Site-directed mutagenesis and molecular dynamics simulations further revealed a built-in motif allowing en bloc insertion of the fusion loop into membranes, making few nonpolar side-chain interactions with the aliphatic moiety and multiple polar interactions with lipid head groups upon membrane restructuring...
November 3, 2017: Science
https://www.readbyqxmd.com/read/29084217/wolbachia-effects-on-rift-valley-fever-virus-infection-in-culex-tarsalis-mosquitoes
#9
Brittany L Dodson, Elizabeth S Andrews, Michael J Turell, Jason L Rasgon
Innovative tools are needed to alleviate the burden of mosquito-borne diseases, and strategies that target the pathogen are being considered. A possible tactic is the use of Wolbachia, a maternally inherited, endosymbiotic bacterium that can (but does not always) suppress diverse pathogens when introduced to naive mosquito species. We investigated effects of somatic Wolbachia (strain wAlbB) infection on Rift Valley fever virus (RVFV) in Culex tarsalis mosquitoes. When compared to Wolbachia-uninfected mosquitoes, there was no significant effect of Wolbachia infection on RVFV infection, dissemination, or transmission frequencies, nor on viral body or saliva titers...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29071255/spatial-scale-in-environmental-risk-mapping-a-valley-fever-case-study
#10
Brown Heidi E, Mu Wangshu, Khan Mohammed, Tsang Clarisse, Liu Jian, Tong Daoqin
BACKGROUND: Valley fever is a fungal infection occurring in desert regions of the U.S. and Central and South America. Environmental risk mapping for this disease is hampered by challenges with detection, case reporting, and diagnostics as well as challenges common to spatial data handling. DESIGN AND METHODS: Using 12,349 individual cases in Arizona from 2006 to 2009, we analyzed risk factors at both the individual and area levels. RESULTS: Risk factors including elderly population, income status, soil organic carbon, and density of residential area were found to be positively associated with residence of Valley fever cases...
September 21, 2017: Journal of Public Health Research
https://www.readbyqxmd.com/read/29069411/distinct-roles-for-the-iiid2-sub-domain-in-pestivirus-and-picornavirus-internal-ribosome-entry-sites
#11
Margaret M Willcocks, Salmah Zaini, Nathalie Chamond, Nathalie Ulryck, Delphine Allouche, Noemie Rajagopalan, Nana A Davids, Ulrik Fahn E, Johanne Hadsbjerg, Thomas Bruun Rasmussen, Lisa O Roberts, Bruno Sargueil, Graham J Belsham, Nicolas Locker
Viral internal ribosomes entry site (IRES) elements coordinate the recruitment of the host translation machinery to direct the initiation of viral protein synthesis. Within hepatitis C virus (HCV)-like IRES elements, the sub-domain IIId(1) is crucial for recruiting the 40S ribosomal subunit. However, some HCV-like IRES elements possess an additional sub-domain, termed IIId2, whose function remains unclear. Herein, we show that IIId2 sub-domains from divergent viruses have different functions. The IIId2 sub-domain present in Seneca valley virus (SVV), a picornavirus, is dispensable for IRES activity, while the IIId2 sub-domains of two pestiviruses, classical swine fever virus (CSFV) and border disease virus (BDV), are required for 80S ribosomes assembly and IRES activity...
October 24, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29063574/public-health-and-epidemiology-informatics
#12
R Thiébaut, F Thiessard
Objectives: To summarize current research in the field of Public Health and Epidemiology Informatics. Methods: The complete 2016 literature concerning public health and epidemiology informatics has been searched in PubMed and Web of Science, and the returned references were reviewed by the two section editors to select 14 candidate best papers. These papers were then peer-reviewed by external reviewers to allow the editorial team an enlightened selection of the best papers. Results: Among the 829 references retrieved from PubMed and Web of Science, three were finally selected as best papers...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063573/best-paper-selection
#13
(no author information available yet)
Kite J, Foley BC, Grunseit AC, Freeman B. Please Like Me: Facebook and Public Health Communication. PLoS One 2016;11(9) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162765 Sharpe JD, Hopkins RS, Cook RL, Striley CW. Evaluating Google, Twitter, and Wikipedia as Tools for Influenza Surveillance Using Bayesian Change Point Analysis: A Comparative Analysis. JMIR Public Health Surveill 2016 20;2(2) http://publichealth.jmir.org/2016/2/e161/ Tran A, Trevennec C, Lutwama J, Sserugga J, Gély M, Pittiglio C, Pinto J, Chevalier V...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29062192/hydrophilic-nanosilica-as-a-new-larvicidal-and-molluscicidal-agent-for-controlling-of-major-infectious-diseases-in-egypt
#14
Marwa M Attia, Soliman M Soliman, Mahmoud A Khalf
AIM: This research was conducted to evaluate the molluscicidal and mosquitocidal efficacy of silica nanoparticles in the eradication of the larvae and pupa of malaria and filariasis vector as well as vectors of rift-valley fever virus (Culex pipiens); Schistosoma mansoni vector and Biomphlaria alexandrina (snail and egg masses). MATERIALS AND METHODS: Hydrophilic nanosilica particles (NSPs) were characterized using transmission electron microscope during the preliminary part of the study; the stages were exposed to upgrade concentrations of NSP from 50 to 1200 ppm each for 24-36 h exposure time...
September 2017: Veterinary World
https://www.readbyqxmd.com/read/29061350/attenuation-and-protective-efficacy-of-rift-valley-fever-phlebovirus-rmp12-gm50-strain
#15
Hoai J Ly, Shoko Nishiyama, Nandadeva Lokugamage, Jennifer K Smith, Lihong Zhang, David Perez, Terry L Juelich, Alexander N Freiberg, Tetsuro Ikegami
Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and the Arabian Peninsula that affects sheep, cattle, goats, camels, and humans. Effective vaccination of susceptible ruminants is important for the prevention of RVF outbreaks. Live-attenuated RVF vaccines are in general highly immunogenic in ruminants, whereas residual virulence might be a concern for vulnerable populations. It is also important for live-attenuated strains to encode unique genetic markers for the differentiation from wild-type RVFV strains...
December 4, 2017: Vaccine
https://www.readbyqxmd.com/read/29048450/aerobiological-monitoring-and-mapping-of-ambrosia-plants-in-the-province-of-parma-northern-italy-southern-po-valley-a-useful-tool-for-targeted-preventive-measures
#16
R Albertini, M Ugolotti, L Ghillani, M Adorni, P Vitali, C Signorelli, C Pasquarella
BACKGROUND: Ambrosia is an annual anemophilous weed producing allergenic pollen affecting public health in European countries. In Italy, the most infested region is Lombardy where, in some areas, it is the major cause of hay fever. In the Parma district, until 2007, Ambrosia seemed to be very rare, despite an observed increase of Seasonal Pollen Index (SPI), of pollen peak value and of asthma among ragweed sensitized patients. The aims of this study were to calculate ragweed pollen season and trends from 1996 to 2015, to assess the relationships between pollen season characteristics and selected meteorological data, to map plants in the territory and to evaluate the presence of beetle Ophraella communa (Ophraella), known as an eater of Ambrosia leaves...
November 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29044082/rickettsial-retinitis-direct-bacterial-infection-or-an-immune-mediated-response
#17
Rohan Chawla, Gadkar Amit Pundlik, Rama Chaudhry, Chandan Thakur
Infectious retinitis postfebrile illness is known to be caused by chikungunya, dengue, West Nile virus, Bartonella, Lyme's disease, Rift Valley fever, rickettsia, Herpes viruses etc. Rickettsia is Gram-negative bacteria transmitted by arthropods vectors. Ocular involvement is common including conjunctivitis, keratitis, anterior uveitis, panuveitis, retinitis, retinal vascular changes, and optic nerve involvement. Retinitis lesions in rickettsia can occur because of an immunological response to the bacteria or because of direct invasion and proliferation of bacteria in the inner retina...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29029619/malaria-prevalence-prevention-and-treatment-seeking-practices-among-nomadic-pastoralists-in-northern-senegal
#18
Mame Cheikh Seck, Julie Thwing, Fatou Ba Fall, Jules Francois Gomis, Awa Deme, Yaye Die Ndiaye, Rachel Daniels, Sarah K Volkman, Medoune Ndiop, Mady Ba, Daouda Ndiaye
BACKGROUND: Malaria transmission in Senegal is highly stratified, from low in the dry north to moderately high in the moist south. In northern Senegal, along the Senegal River Valley and in the Ferlo semi-desert region, annual incidence is less than five cases per 1000 inhabitants. Many nomadic pastoralists have permanent dwellings in the Ferlo Desert and Senegal River Valley, but spend dry season in the south with their herds, returning north when the rains start, leading to a concern that this population could contribute to ongoing transmission in the north...
October 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28985319/rift-valley-fever-does-wildlife-play-a-role
#19
Melinda K Rostal, Janice E Liang, David Zimmermann, Roy Bengis, Janusz Paweska, William B Karesh
Rift Valley fever (RVF) virus (RVFV) is an emerging vector-borne pathogen that causes sporadic epizootics and epidemics with multi-year, apparently quiescent, inter-epidemic periods. The epidemiology and ecology of the virus during these inter-epidemic periods is poorly understood. There is evidence for low-level circulation of the virus in livestock and wild ruminants; however, as of yet there is no evidence to identify a specific mammalian reservoir host. Using a systematic approach, this review synthesizes results from serosurveys, attempts at viral detection, and experimental infection of wildlife...
August 31, 2017: ILAR Journal
https://www.readbyqxmd.com/read/28926632/risk-analysis-of-inter-species-reassortment-through-a-rift-valley-fever-phlebovirus-mp-12-vaccine-strain
#20
Hoai J Ly, Nandadeva Lokugamage, Shoko Nishiyama, Tetsuro Ikegami
Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and the Arabian Peninsula. The causative agent, Rift Valley fever phlebovirus (RVFV), belongs to the genus Phlebovirus in the family Phenuiviridae and causes high rates of abortions in ruminants, and hemorrhagic fever, encephalitis, or blindness in humans. Viral maintenance by mosquito vectors has led to sporadic RVF outbreaks in ruminants and humans in endemic countries, and effective vaccination of animals and humans may minimize the impact of this disease...
2017: PloS One
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