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https://www.readbyqxmd.com/read/28822394/the-clinical-utility-and-cost-of-postoperative-mammography-completed-within-one-year-of-breast-conserving-therapy-is-it-worth-it
#1
Ahkeel Allen, Allison Cauthen, Justin Vaughan, Paul Dale
Breast conserving therapy (BCT), lumpectomy followed by radiotherapy, is an effective treatment for a majority of breast cancers. According to the National Comprehensive Cancer Network, mammographic imaging should be completed at least six months after completion of radiation. This study evaluates the clinical significance and financial cost of postoperative breast imaging within one year of BCT. Patients treated with BCT between 2014 and 2016 at an academic center were identified retrospectively. The medical records were reviewed to identify the timing and type of the first imaging study after BCT...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28821268/hypo-fractionated-sbrt-for-localized-prostate-cancer-a-german-bi-center-single-treatment-group-feasibility-trial
#2
Ping Jiang, Katja Krockenberger, Reinhard Vonthein, Jane Tereszczuk, Arne Schreiber, Sebastian Liebau, Stefan Huttenlocher, Detlef Imhoff, Panagiotis Balermpas, Christian Keller, Kathrin Dellas, Rene Baumann, Claus Rödel, Guido Hildebrandt, Klaus-Peter Jünemann, Alex S Merseburger, Alan Katz, Andreas Ziegler, Oliver Blanck, Jürgen Dunst
BACKGROUND: For prostate cancer treatment, treatment options with minimal side effects are desired. External beam radiation therapy (EBRT) is non-invasive, standard of care and delivered in either conventional fractionation over 8 weeks or with moderate hypo-fractionation over about 5 weeks. Recent advances in radiotherapy technology have made extreme hypo-fractionated stereotactic body radiation therapy (SBRT) of prostate cancer feasible, which has not yet been introduced as a standard treatment method in Germany...
August 18, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28817374/long-term-survival-outcomes-of-cancer-directed-surgery-for-malignant-pleural-mesothelioma-propensity-score-matching-analysis
#3
David B Nelson, David C Rice, Jiangong Niu, Scott Atay, Ara A Vaporciyan, Mara Antonoff, Wayne L Hofstetter, Garrett L Walsh, Stephen G Swisher, Jack A Roth, Anne Tsao, Daniel Gomez, Sharon H Giordano, Reza Mehran, Boris Sepesi
Purpose Small observational studies have shown a survival advantage to undergoing cancer-directed surgery for malignant pleural mesothelioma (MPM); however, it is unclear if these results are generalizable. Our purpose was to evaluate survival after treatment of MPM with cancer-directed surgery and to explore the effect surgery interaction with chemotherapy or radiation therapy on survival by using the National Cancer Database. Patients and Methods Patients with microscopically proven MPM were identified within the National Cancer Database (2004 to 2014)...
August 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28814898/reducing-rectal-injury-in-men-receiving-prostate-cancer-radiation-therapy-current-perspectives
#4
REVIEW
Nicholas A Serrano, Noah S Kalman, Mitchell S Anscher
Dose escalation is now the standard of care for the treatment of prostate cancer with radiation therapy. However, the rectum tends to be the dose-limiting structure when treating prostate cancer, given its close proximity. Early and late toxicities can occur when the rectum receives large doses of radiation therapy. New technologies allow for prevention of these toxicities. In this review, we examine the evidence that supports various dose constraints employed to prevent these rectal injuries from occurring...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28801009/management-of-radiation-side-effects-to-the-skin
#5
REVIEW
Tracy Gieger, Michael Nolan
Radiation therapy (RT) is an essential component for management of many cancers. Veterinary health care professionals must counsel owners about the potential side effects of RT, the anticipated management plan, and associated costs. For most veterinary patients treated with RT, acute radiation side effects are mild; however, careful radiation treatment planning and appropriate management of acute side effects are essential to try to prevent chronic sequelae and the need for ongoing wound care. This article reviews acute and late side effects to the skin and their management...
August 9, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28798701/a-qualitative-investigation-on-patient-empowerment-in-prostate-cancer
#6
Chiara Renzi, Chiara Fioretti, Serena Oliveri, Ketti Mazzocco, Dario Zerini, Ombretta Alessandro, Damaris P Rojas, Barbara A Jereczek-Fossa, Gabriella Pravettoni
Purpose: Men with prostate cancer often describe low levels of empowerment. eHealth interventions may represent useful tools to deliver care and education and to meet patients' needs within an empowerment framework. In order to design a platform for cancer patients' empowerment within the H2020 iManageCancer project, the perspective of the target population for the platform was assessed. The present study aims to assess the qualitative experience of prostate cancer patients during treatment in order to provide insights for clinical practice with a particular focus on the design of a web platform to promote cancer patients' empowerment...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28776126/management-of-urethral-stricture-and-bladder-neck-contracture-following-primary-and-salvage-treatment-of-prostate-cancer
#7
REVIEW
Brendan Michael Browne, Alex J Vanni
PURPOSE OF REVIEW: This article discusses the incidence, evaluation, and treatment of bladder outlet obstruction from urethral stricture, vesicourethral anastomotic stricture, and bladder neck contracture following primary and salvage treatment of prostate cancer. RECENT FINDINGS: Rates of stenosis after prostate cancer treatment appear similar across all primary treatment modalities including radical prostatectomy, radiation therapy, cryoablation, and high-intensity focused ultrasound in contemporary series...
October 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28766004/-psychosocial-stress-in-patients-with-prostate-cancer-experiences-by-using-psychooncological-screening-questionnaires
#8
D L Dräger, N N Harke, K-D Sievert, C Protzel, O W Hakenberg
BACKGROUND: Prostate cancer is the most common malignancy in men and accounts for most surgical procedures in uro-oncology. Stressful sequelae of radical prostatectomy are incontinence and erectile dysfunction. Hormone ablation and radiation therapy are also known stressors. Mental stress has a low prevalence compared to other tumor entities. It is highly probable that there is an underexpression of verbally reported emotional experiences. Therefore, a low-threshold access to psycho-oncological services and accurate identification of patients with mental comorbidities is important...
August 1, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28760449/tumor-microenvironment-determines-response-to-a-heat-activated-thermosensitive-liposome-formulation-of-cisplatin-in-cervical-carcinoma
#9
Yannan N Dou, Naz Chaudary, Martin C Chang, Michael Dunne, Huang Huang, David A Jaffray, Michael Milosevic, Christine Allen
Significant heterogeneity in the tumor microenvironment of human cervical cancer patients is known to challenge treatment outcomes in this population. The current standard of care for cervical cancer patients is radiation therapy and concurrent cisplatin (CDDP) chemotherapy. Yet this treatment strategy fails to control loco-regional disease in 10-30% of patients. In order to improve the loco-regional control rate, a thermosensitive liposome formulation of CDDP (HTLC) was developed to increase local concentrations of drug in response to mild hyperthermia (HT)...
July 29, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28759121/health-care-disparities-among-octogenarians-and-nonagenarians-with-stage-ii-and-iii-rectal-cancer
#10
Richard J Cassidy, Jeffrey M Switchenko, En Cheng, Renjian Jiang, Jaymin Jhaveri, Kirtesh R Patel, Daniel G Tanenbaum, Maria C Russell, Conor E Steuer, Theresa W Gillespie, Mark W McDonald, Jerome C Landry
BACKGROUND: Octogenarians and nonagenarians with stage II/III rectal adenocarcinomas are underrepresented in the randomized trials that have established the standard-of-care therapy of preoperative chemoradiation followed by definitive resection (ie, chemoradiation and then surgery [CRT+S]). The purpose of this study was to evaluate the impact of therapies on overall survival (OS) for patients with stage II/III rectal cancers and determine predictors of therapy within the National Cancer Data Base (NCDB)...
July 31, 2017: Cancer
https://www.readbyqxmd.com/read/28756338/patterns-of-care-for-ductal-carcinoma-in-situ-of-the-breast-queensland-s-experience-over-a-decade
#11
Samantha Barbour, Julie Moore, Nathan Dunn, Rachel Effeney, Hazel Harden, Alexandra McCarthy, Euan Walpole, Margot Lehman
OBJECTIVES: To review management of ductal carcinoma in situ (DCIS) of the breast in Queensland, with reference to breast conserving surgery (BCS) and adjuvant radiation therapy (RT). In addition, we examined the incidence of invasive breast cancer recurrence and factors predictive of invasive recurrence. MATERIALS AND METHODS: A retrospective review of the Queensland Oncology Repository identified women with resected DCIS (TisN0) ± adjuvant RT between 2003 and 2012...
July 27, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28752860/enhancing-the-cytotoxicity-of-chemoradiation-with-radiation-guided-delivery-of-anti-mgmt-morpholino-oligonucleotides-in-non-methylated-solid-tumors
#12
P Ambady, Y J Wu, J M Walker, C Kersch, M A Pagel, R L Woltjer, R Fu, L L Muldoon, E A Neuwelt
The DNA repair enzyme O(6)-methylguanine DNA methyltransferase (MGMT) is epigenetically silenced in some tumors by MGMT gene promoter methylation. MGMT-hypermethylated solid tumors have enhanced susceptibility to the cytotoxic effects of alkylating chemotherapy such as temozolomide, compared with non-methylated tumors. In glioblastoma, subjects with MGMT hypermethylation have significantly longer survival rates after chemoradiotherapy. We report the first successful use of a non-ablative dose of ionizing radiation to prime human cancer cells to enhance the uptake of unmodified anti-MGMT morpholino oligonucleotide (AMON) sequences...
July 28, 2017: Cancer Gene Therapy
https://www.readbyqxmd.com/read/28750593/the-role-of-external-beam-radiation-therapy-in-well-differentiated-thyroid-cancer
#13
Sarah N Hamilton, Eric Tran, Eric Berthelet, John Wu
dglkf Introduction: This review article explores the use of external beam radiotherapy (EBRT) in well differentiated thyroid cancer. Areas covered: The published literature on EBRT for advanced pT4 disease and macroscopic unresectable disease to improve locoregional control is reviewed. EBRT techniques, volumes and doses are discussed in detail. The potential acute and late toxicities of EBRT are discussed in the context of the published literature. The use of EBRT for patients with metastatic disease is also described...
July 28, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28749165/impact-of-robotic-ultrasound-image-guidance-on-plan-quality-in-sbrt-of-the-prostate
#14
Stefan Gerlach, Ivo Kuhlemann, Floris Ernst, Christoph Fürweger, Alexander Schlaefer
OBJECTIVES: Ultrasound provides good image quality, fast volumetric imaging, and is established for abdominal image guidance. Robotic transducer placement may facilitate intra-fractional motion compensation in radiation therapy. We consider integration with the CyberKnife and study whether the kinematic redundancy of a seven-degrees-of-freedom robot allows for acceptable plan quality for prostate treatments. METHODS: Reference treatment plans were generated for ten prostate cancer cases previously treated with the CyberKnife...
July 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28748445/surgeon-and-radiation-oncologist-views-on-omission-of-adjuvant-radiotherapy-for-older-women-with-early-stage-breast-cancer
#15
Dean A Shumway, Kent A Griffith, Michael S Sabel, Rochelle D Jones, Julie M Forstner, Terri L Bott-Kothari, Sarah T Hawley, Jacqueline Jeruss, Reshma Jagsi
PURPOSE: Although clinical trials have shown no survival advantage and only a modest improvement in local control from adjuvant radiotherapy after lumpectomy in older women with stage I, estrogen receptor-positive (ER+) breast cancer, radiotherapy is commonly administered, raising concerns about overtreatment. Therefore, we sought to evaluate physician views on omission of radiotherapy in older women with favorable prognosis breast cancer. METHODS: We surveyed a national sample of 713 radiation oncologists and 879 surgeons...
July 26, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28740929/preserving-the-legacy-of-reirradiation-a-narrative-review-of-historical-publications
#16
REVIEW
Carsten Nieder, Johannes A Langendijk, Matthias Guckenberger, Anca L Grosu
PURPOSE: The purpose of this study is to illustrate the historical development of reirradiation during several decades of the 20th century, in particular between 1920 and 1960. METHODS AND MATERIALS: We chose the format of a narrative review because the historical articles are heterogeneous. No systematic extraction of baseline data, treatment details, or follow-up care was possible in many cases. RESULTS: Both hematological malignancies and solid tumors were treated with a second course of radiation therapy, and indications included local relapse, regional nodal recurrence, and second primary tumors developing in a previously treated region...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740890/satisfaction-of-breast-cancer-patients-regarding-surgery-and-radiation-therapy-a-survey-in-japan
#17
Anneyuko I Saito, Masaru Suda, Keisuke Sasai, Reshma Jagsi
PURPOSE: To evaluate patient satisfaction in Japan and factors, including timing factors, cost, and specific medical practices derived from Western influence (shared decision-making and second opinion), which might affect satisfaction. METHODS AND MATERIALS: All patients who presented to 1 large Japanese department of radiation oncology for postoperative radiation therapy for breast cancer from September 2010 to November 2013 were included in this study. The questionnaire was distributed to patients after the radiation oncologist consultation, and patients were asked to complete it anonymously by the end of treatment...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28739159/lung-stereotactic-body-radiation-therapy-sbrt-for-early-stage-non-small-cell-lung-cancer-in-the-very-elderly-%C3%A2-80years-old-extremely-safe-and-effective
#18
Paul Kreinbrink, Philip Blumenfeld, George Tolekidis, Neilayan Sen, David Sher, Gaurav Marwaha
OBJECTIVE: Stereotactic body radiotherapy (SBRT) for early-stage non-small-cell lung cancer (NSCLC) is the standard of care in medically inoperable patients. In very elderly patients, previous studies have shown SBRT to offer excellent local control, though with higher toxicities than in younger populations. We report our institutional experience using SBRT in the definitive management of NSCLC in patients ≥80years old. MATERIALS AND METHODS: Using an IRB-approved registry of 158 patients treated with definitive-intent lung SBRT for early-stage NSCLC at our institution between 2010 and 2016, 31 consecutively treated patients ≥80years of age were identified...
July 21, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28739142/radiation-therapy-for-oligorecurrence-in-prostate-cancer-preliminary-results-of-our-centre
#19
C González Ruiz de León, M Ramírez Backhaus, M Sobrón Bustamante, J Casaña, L Arribas, J Rubio-Briones
INTRODUCTION AND OBJECTIVE: There is growing interest in the use of more aggressive therapeutic modalities for treating metastatic prostate cancer. In this study, we examine the use of stereotactic body radiation therapy (SBRT) for patients with oligorecurrent prostate cancer. We analysed the biochemical response and toxicity of patients who underwent this therapy at our centre. MATERIAL AND METHOD: We selected patients who experienced oligorecurrence between January 2015 to December 2016 and were administered SBRT...
July 21, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28736725/intraoperative-radiation-therapy-a-promising-treatment-modality-in-head-and-neck-cancer
#20
REVIEW
Lara Hilal, Karine A Al Feghali, Paul Ramia, Ibrahim Abu Gheida, Jean-Pierre Obeid, Wassim Jalbout, Bassem Youssef, Fady Geara, Youssef H Zeidan
Every year, almost 62,000 are diagnosed with a head and neck cancer (HNC) and 13,000 will succumb to their disease. In the primary setting, intraoperative radiation therapy (IORT) can be used as a boost in select patients in order to optimize local control. Addition of external beam radiation to limited volumes results in improved disease control over surgery and IORT alone. In the recurrent setting, IORT can improve outcomes from salvage surgery especially in patients previously treated with external beam radiation...
2017: Frontiers in Oncology
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