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https://www.readbyqxmd.com/read/28636235/stem-cell-based-tooth-and-periodontal-regeneration
#1
Lei Hu, Yi Liu, Songlin Wang
Currently regeneration of tooth and periodontal damage still remains great challenge. Stem cell-based tissue engineering raised novel therapeutic strategies for tooth and periodontal repair. Stem cells for tooth and periodontal regeneration include dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs), stem cells from the dental apical papilla (SCAPs), and stem cells from human exfoliated deciduous teeth (SHEDs), dental follicle stem cells (DFSCs), dental epithelial stem cells (DESCs), bone marrow mesenchymal stem cells (BMMSCs), adipose-derived stem cells (ADSCs), embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)...
June 21, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28636007/analysis-of-association-of-gene-variants-with-obesity-traits-in-new-zealand-european-children-at-6-years-of-age
#2
Mohanraj Krishnan, John M D Thompson, Edwin A Mitchell, Rinki Murphy, Lesley M E McCowan, Andrew N Shelling, G On Behalf Of The Children Of Scope Study Group
Childhood obesity is a public health problem, which is associated with a long-term increased risk of cardiovascular disease and premature mortality. Several gene variants have previously been identified that have provided novel insights into biological factors that contribute to the development of obesity. As obesity tracks through childhood into adulthood, identification of the genetic factors for obesity in early life is important. The objective of this study was to identify putative associations between genetic variants and obesity traits in children at 6 years of age...
June 21, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28634757/a-uhplc-ms-ms-method-for-profiling-multifunctional-steroids-in-human-hair
#3
Zhen Dong, Caihong Wang, Jinlan Zhang, Zhe Wang
It is important to profile steroids in many physiological and pathological processes. Recently, hair has been used for the long-term measurement of endogenous steroid hormones. Analyzing hair has advantages of being noninvasive and time sequential compared with other bio-specimens. Liquid chromatography-mass spectrometry (LC-MS) techniques have been widely used over the past decades; however, it is challenging to profile estrogens in hair by LC-MS, and more comprehensive steroid profiling is required. In this paper, an ultra high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed to simultaneously profile 28 multifunctional steroids, including corticosteroids (n = 6), estrogens (n = 13), androgens (n = 5) and progestogens (n = 4), in human scalp hair in a single run...
June 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28634719/a-sugarcane-pathogenesis-related-protein-scpr10-plays-a-positive-role-in-defense-responses-under-sporisorium-scitamineum-srmv-sa-and-meja-stresses
#4
Qiong Peng, Yachun Su, Hui Ling, Waqar Ahmad, Shiwu Gao, Jinlong Guo, Youxiong Que, Liping Xu
A pathogenesis-related gene, ScPR10 , was isolated from sugarcane and its bio-function was characterized, demonstrating that ScPR10 was involved in plant defense responses to Sporisorium scitamineum , SrMV, SA, and MeJA stresses. Plant fungal and viral diseases are the major concerns in sugarcane industry. Many anti-fungal and antivirus components, including pathogenesis-related (PR) proteins, have been identified. The pathogenesis-related protein 10 (PR10) is the dominant group in PR families, involved in the plant defense mechanism...
June 20, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28634713/characterization-and-in-vitro-antibacterial-activity-of-saponin-conjugated-silver-nanoparticles-against-bacteria-that-cause-burn-wound-infection
#5
Anbarasan Muniyan, Kalaiselvi Ravi, Udayamathi Mohan, Rajasekar Panchamoorthy
Saponins are glycosides, which destabilize the membrane by altering the membrane permeability. Thus, the present study was aimed to fabricate the silver nanoparticles (AgNPs) using fenugreek derived saponin (SN) against multi-drug resistant bacteria. This study has optimized the concentration of SN (240 mg/mL) for the synthesis of an effective AgNPs against the test organism Escherichia coli. The SN reduced AgNPs produced a reddish-brown colour and displayed UV absorption at 416 nm. The bio-reducing efficiency of SN (62...
July 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28634127/application-of-advanced-techniques-for-the-assessment-of-bio-stability-of-biowaste-derived-residues-a-minireview
#6
REVIEW
Fan Lü, Li-Ming Shao, Hua Zhang, Wen-Ding Fu, Shi-Jin Feng, Liang-Tong Zhan, Yun-Min Chen, Pin-Jing He
Bio-stability is a key feature for the utilization and final disposal of biowaste-derived residues, such as aerobic compost or vermicompost of food waste, bio-dried waste, anaerobic digestate or landfilled waste. The present paper reviews conventional methods and advanced techniques used for the assessment of bio-stability. The conventional methods are reclassified into two categories. Advanced techniques, including spectroscopic (fluorescent, ultraviolet-visible, infrared, Raman, nuclear magnetic resonance), thermogravimetric and thermochemolysis analysis, are emphasized for their application in bio-stability assessment in recent years...
June 12, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28634118/identification-of-chickpea-seed-proteins-resistant-to-simulated-in-vitro-human-digestion
#7
I C Ribeiro, C C Leclercq, N Simões, A Toureiro, I Duarte, J B Freire, M M Chaves, J Renaut, C Pinheiro
Proteins and peptides able to resist gastrointestinal digestion and reach the intestinal mucosa have the potential to influence human health. Chickpea (Cicer arietinum L.) seed proteins are able to resist cooking (86.9% total protein) and/or in vitro simulated human digestion (15.9% total protein resists soaking, cooking and digestion with pepsin and pancreatin). To identify and characterize proteins resisting digestion we made use of different MS methodologies. The efficiency of several proteases (trypsin, AspN, chymotrypsin and LysC) was tested, and two technologies were employed (MALDI-TOF-TOF and LC-nESI-MS/MS)...
June 17, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28634022/goals-and-objectives-of-the-italian-network-for-tumor-biotherapy-nibit
#8
Vincenzo Russo, Alberto Amadori, Marco Bregni, Luana Calabrò, Mario Paolo Colombo, Massimo Di Nicola, Pier Francesco Ferrucci, Enrico Proietti, Michele Maio, Matteo Bellone
The explosion in the immuno-oncology field, exemplified by the clinical implementation of immune checkpoint inhibitor blockade and other immunotherapeutic strategies was quickly recognized by the Italian biomedical community, thanks to the networking activities of the Italian Network for Tumor Biotherapy (NIBIT), which has been active since 2004 in the diffusion of new scientific and clinical findings in the fields of tumor immunology and immunotherapy. Numerous activities of NIBIT have also helped to overcome the hurdles associated with the clinical implementation of cancer immune-biotherapeutic strategies at the national and international levels...
June 16, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/28633759/martini-coarse-grained-force-field-extension-to-rna
#9
Jaakko J Uusitalo, Helgi I Ingólfsson, Siewert J Marrink, Ignacio Faustino
RNA has an important role not only as the messenger of genetic information but also as a regulator of gene expression. Given its central role in cell biology, there is significant interest in studying the structural and dynamic behavior of RNA in relation to other biomolecules. Coarse-grain molecular dynamics simulations are a key tool to that end. Here, we have extended the coarse-grain Martini force field to include RNA after our recent extension to DNA. In the same way DNA was modeled, the tertiary structure of RNA is constrained using an elastic network...
June 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28633514/metagenomic-smrt-sequencing-based-exploration-of-novel-lignocellulose-degrading-capability-in-wood-detritus-from-torreya-nucifera-in-bija-forest-on-jeju-island
#10
Han Na Oh, Tae Kwon Lee, Jae Wan Park, Jee Hyun No, Dockyu Kim, Woo Jun Sul
Lignocellulose, mostly composed of cellulose, hemicellulose and lignin generated through secondary growth of woody plant, is considered as promising resources for bio-fuel. In order to use lignocellulose as a biofuel, the biodegradation besides high-cost chemical treatments were applied, but its knowledge on decomposition of lignocellulose occurring in a natural environment were insufficient. We analyzed 16S rRNA gene and metagenome to understand how the lignocellulose are decomposed naturally in decayed Torreya nucifera (L) of Bija forest (Bijarim) in Gotjawal, an ecologically distinct environment...
June 21, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28633113/transformation-and-toxicity-assessment-of-two-uv-filters-using-uv-h2o2-process
#11
Mingguo Peng, Erdeng Du, Zhihong Li, Dongdong Li, Huajie Li
The treatment of two typical UV filters benzophenone-4 (BP4) and benzophenone-9 (BP9) was evaluated in aqueous solutions by UV/H2O2 process. High-resolution accurate mass spectrometry (HRMS) was used to identify the degradation intermediates. A total of 12 BP4 degradation products and 17 BP9 degradation products were identified. A series of OH-initiated reactions, including hydroxylation, dihydroxylation, decarboxylation, demethylation, and ring breaking, lead to the final mineralization of BP4 and BP9. The degradation mechanisms of BP4 and BP9 are also proposed, separately...
June 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28632959/defect-based-modulation-of-opto-electronic-properties-for-bio-functionalized-hexagonal-boron-nitride-nanosheets
#12
Mehdi Shakourian-Fard, Hadiseh Heydari, Ganesh Kamath
Defect engineering could potentially allow for dramatic tuning of optoelectronic properties of two-dimensional materials. With the help of density functional theory (DFT) calculations, we present a systematic study of the DNA Nucleobases (NBs) adsorbed on hexagonal boron-nitride nanoflake (h-BNNF) and boron and nitrogen monovacancies. The presence of such VN and VB defects increases the binding strength of NBs by 9 kcal/mol and 34 kcal/mol, respectively (h-BNNF-VB> h-BNNF-VN> h-BNNF). A more negative electrostatic potential at the B vacancy-site makes h-BNNF-VB surface more reactive than h-BNNF-VN surface enabling H-bonding interactions with NBs...
June 20, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28632832/-a-hundred-years-since-the-beginning-of-the-great-war-trichinosis-outbreak-in-dresden-marine-in-chile-chronicle-of-an-announced-infection
#13
Italo Fernández, Alejandro Mihovilovich
In commemoration of one hundred years of the beginning of World War I, the occurrence of an outbreak of trichinosis in the crew of the SMS Dresden, a German ship that participated in that world conflagration, is re-viewed. In September 1915, while the sailors of SMS Dresden were forcibly detained on Isla Quiriquina, Bío Bío Region, Chile, 60 individuals became ill. The cause of the outbreak was the consumption of sausages made from pork infected with the parasite Trichinella spiralis. There was a fatal case...
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28632265/3d-printed-conformal-microfluidics-for-isolation-and-profiling-of-biomarkers-from-whole-organs
#14
Manjot Singh, Yuxin Tong, Kelly Webster, Ellen Cesewski, Alexander P Haring, Sahil Laheri, Bill Carswell, Timothy J O'Brien, Charles H Aardema, Ryan S Senger, John L Robertson, Blake N Johnson
The ability to interface microfluidic devices with native complex biological architectures, such as whole organs, has the potential to shift the paradigm for the study and analysis of biological tissue. Here, we show 3D printing can be used to fabricate bio-inspired conformal microfluidic devices that directly interface with the surface of whole organs. Structured-light scanning techniques enabled the 3D topographical matching of microfluidic device geometry to porcine kidney anatomy. Our studies show molecular species are spontaneously transferred from the organ cortex to the conformal microfluidic device in the presence of fluid flow through the organ-conforming microchannel...
June 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28631927/stabilization-of-a-virus-like-particle-and-its-application-as-a-nanoreactor-at-physiological-conditions
#15
Lise Schoonen, Sjors Maassen, Roeland J M Nolte, Jan C M van Hest
Virus-like particles are very interesting tools for application in bio-nanotechnology, due to their monodisperse features and biocompatibility. In particular, the cowpea chlorotic mottle virus (CCMV) capsid has been studied extensively as it can be assembled and disassembled reversibly, facilitating cargo encapsulation. CCMV is, however, only stable at physiological conditions when its endogenous nucleic acid cargo is present. To gain more flexibility in the type of cargo encapsulated and to broaden the window of operation, it is interesting to improve the stability of the empty virus-like particles...
June 20, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28631623/morphological-self-stabilization-of-locomotion-gaits-illustration-on-a-few-examples-from-bio-inspired-locomotion
#16
Christine Chevallereau, Frédéric Boyer, Mathieu Porez, Johan Mauny, Yannick Aoustin
To a large extent, robotics locomotion can be viewed as cyclic motions, named gaits. Due to the high complexity of the locomotion dynamics, to find the control laws that ensure an expected gait and its stability with respect to external perturbations, is a challenging issue for feedback control. To address this issue, a promising way is to take inspiration from animals that intensively exploit the interactions of the passive degrees of freedom of their body with their physical surroundings, to outsource the high-level exteroceptive feedback control to low-level proprioceptive ones...
June 20, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28631060/estimating-the-size-of-the-msm-population-in-metro-vancouver-canada-using-multiple-methods-and-diverse-data-sources
#17
Ashleigh J Rich, Nathan J Lachowsky, Paul Sereda, Zishan Cui, Jason Wong, Stanley Wong, Jody Jollimore, Henry Fisher Raymond, Travis Salway Hottes, Eric A Roth, Robert S Hogg, David M Moore
Men who have sex with men (MSM) are disproportionately affected by HIV globally, regionally in Canada, and locally in Vancouver. Lack of reliable population size estimates of MSM impedes effective implementation of health care services and limits our understanding of the HIV epidemic. We estimated the population size of MSM residing in Metro Vancouver drawing on four data sources: the Canadian Community Health Survey (CCHS), a cross-sectional bio-behavioural MSM survey, HIV testing services data from sexually transmitted infection (STI) clinics serving MSM, and online social networking site Facebook...
June 19, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28630908/biofuel-by-isomerizing-metathesis-of-rapeseed-oil-esters-with-bio-ethylene-for-use-in-contemporary-diesel-engines
#18
Kai F Pfister, Sabrina Baader, Mathias Baader, Silvia Berndt, Lukas J Goossen
Rapeseed oil methyl ester (RME) and (bio)ethylene are converted into biofuel with an evenly rising boiling point curve, which fulfills the strict boiling specifications prescribed by the fuel standard EN 590 for modern (petro)diesel engines. Catalyzed by a Pd/Ru system, RME undergoes isomerizing metathesis in a stream of ethylene gas, leading to a defined olefin, monoester, and diester blend. This innovative refining concept requires negligible energy input (60°C) and no solvents and does not produce waste...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28630679/molecular-interactions-of-amyloid-nanofibrils-with-biological-aggregation-modifiers-implications-for-cytotoxicity-mechanisms-and-biomaterial-design
#19
REVIEW
Durga Dharmadana, Nicholas P Reynolds, Charlotte E Conn, Céline Valéry
Amyloid nanofibrils are ubiquitous biological protein fibrous aggregates, with a wide range of either toxic or beneficial activities that are relevant to human disease and normal biology. Protein amyloid fibrillization occurs via nucleated polymerization, through non-covalent interactions. As such, protein nanofibril formation is based on a complex interplay between kinetic and thermodynamic factors. The process entails metastable oligomeric species and a highly thermodynamically favoured end state. The kinetics, and the reaction pathway itself, can be influenced by third party moieties, either molecules or surfaces...
August 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28630465/changes-in-pore-structure-of-coal-caused-by-coal-to-gas-bioconversion
#20
Rui Zhang, Shimin Liu, Jitendra Bahadur, Derek Elsworth, Yi Wang, Guanglong Hu, Yanna Liang
Microbial enhanced coalbed methane (ME-CBM) recovery is critically examined as a viable technology for natural gas recovery from coalbed methane (CBM) reservoirs. Since the majority of gas-in-place (GIP) is stored as an adsorbed phase in fine pores of coal matrix, the nano-pore structure directly influences gas storage and transport properties. Only limited studies have quantified the alteration of the nano-pore structure due to ME-CBM treatment. This study examines the evolution of the pore structure using a combination of small angle X-ray scattering (SAXS), low-pressure N2 and CO2 adsorption (LPGA) and high-pressure methane adsorption methods...
June 19, 2017: Scientific Reports
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