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https://www.readbyqxmd.com/read/28231171/application-of-hybrid-genetic-algorithm-routine-in-optimizing-food-and-bioengineering-processes
#1
Jaya Shankar Tumuluru, Richard McCulloch
Optimization is a crucial step in the analysis of experimental results. Deterministic methods only converge on local optimums and require exponentially more time as dimensionality increases. Stochastic algorithms are capable of efficiently searching the domain space; however convergence is not guaranteed. This article demonstrates the novelty of the hybrid genetic algorithm (HGA), which combines both stochastic and deterministic routines for improved optimization results. The new hybrid genetic algorithm developed is applied to the Ackley benchmark function as well as case studies in food, biofuel, and biotechnology processes...
November 9, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28230987/urinary-antibiotics-of-pregnant-women-in-eastern-china-and-cumulative-health-risk-assessment
#2
Hexing Wang, Na Wang, Junhua Qian, Lingyun Hu, Peixin Huang, Meifang Su, Xin Yu, Chaowei Fu, Feng Jiang, Qi Zhao, Ying Zhou, Haijiang Lin, Gengsheng He, Yue Chen, Qingwu Jiang
Exposure to antibiotics during pregnancy can pose a systematic effect on human health. A few bio-monitoring studies have demonstrated an extensive exposure of children to antibiotics, but there is still lack of data for pregnant women. To assess the exposure of pregnant women to antibiotics and potential health risk, we investigated 536 pregnant women aged 16-42 years from two geographically different study sites in Eastern China in 2015. We measured 21 antibiotics of five categories (seven fluoroquinolones, three phenicols, four tetracyclines, three macrolides, and four sulfonamides) in urines by using the isotope dilution ultra-performance liquid chromatography coupled to quadrupole time of-flight mass spectrometry...
February 23, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28230803/one-pot-conversion-of-epoxidized-soybean-oil-eso-into-soy-based-polyurethanes-by-mocl%C3%A2-o%C3%A2-catalysis
#3
Vincenzo Pantone, Cosimo Annese, Caterina Fusco, Paola Fini, Angelo Nacci, Antonella Russo, Lucia D'Accolti
An innovative and eco-friendly one-pot synthesis of bio-based polyurethanes is proposed via the epoxy-ring opening of epoxidized soybean oil (ESO) with methanol, followed by the reaction of methoxy bio-polyols intermediates with 2,6-tolyl-diisocyanate (TDI). Both synthetic steps, methanolysis and polyurethane linkage formation, are promoted by a unique catalyst, molybdenum(VI) dichloride dioxide (MoCl₂O₂), which makes this procedure an efficient, cost-effective, and environmentally safer method amenable to industrial scale-up...
February 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28230480/the-micro-bio-trojans-free-living-amoebae-as-reservoirs-for-human-pathogens-giant-viruses-and-other-surprises
#4
Bärbel Hauröder, Rolf Michel
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28230202/ecosystem-composition-controls-the-fate-of-rare-earth-elements-during-incipient-soil-genesis
#5
Dragos G Zaharescu, Carmen I Burghelea, Katerina Dontsova, Jennifer K Presler, Raina M Maier, Travis Huxman, Kenneth J Domanik, Edward A Hunt, Mary K Amistadi, Emily E Gaddis, Maria A Palacios-Menendez, Maria O Vaquera-Ibarra, Jon Chorover
The rare earth elements (REE) are increasingly important in a variety of science and economic fields, including (bio)geosciences, paleoecology, astrobiology, and mining. However, REE distribution in early rock-microbe-plant systems has remained elusive. We tested the hypothesis that REE mass-partitioning during incipient weathering of basalt, rhyolite, granite and schist depends on the activity of microbes, vascular plants (Buffalo grass), and arbuscular mycorrhiza. Pore-water element abundances revealed a rapid transition from abiotic to biotic signatures of weathering, the latter associated with smaller aqueous loss and larger plant uptake...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229956/development-of-a-thermosensitive-hama-containing-bio-ink-for-the-fabrication-of-composite-cartilage-repair-constructs
#6
Vivian Hilda Maria Mouser, Anna Abbadessa, Riccardo Levato, Wim Hennink, Tina Vermonden, Debby Gawlitta, Jos Malda
Fine-tuning of bio-ink composition and material processing parameters is crucial for the development of biomechanically relevant cartilage constructs. This study aims to design and develop cartilage constructs with tunable internal architectures and relevant mechanical properties. More specifically, the potential of methacrylated hyaluronic acid (HAMA) added to thermosensitive hydrogels composed of methacrylated poly[N-(2-hydroxypropyl)methacrylamide mono/dilactate] (pHPMA-lac)/polyethylene glycol (PEG) triblock copolymers, to optimize cartilage-like tissue formation by embedded chondrocytes, and enhance printability was explored...
February 23, 2017: Biofabrication
https://www.readbyqxmd.com/read/28229593/development-of-laser-structured-liquid-infused-titanium-with-strong-biofilm-repellent-properties
#7
Katharina Doll, Elena Fadeeva, Joern Schaeske, Tobias Ehmke, Andreas Winkel, Alexander Heisterkamp, Boris N Chichkov, Meike Stiesch, Nico S Stumpp
Medical implants are commonly used in modern medicine but still harbor the risk of microbial infections caused by bacterial biofilms. As their retrospective treatment is difficult, there is a need for biomedical materials, which inhibit bacterial colonization from the start without using antibacterial agents, as these can promote resistance development. The promising concept of slippery liquid-infused porous surfaces (SLIPS) possesses enormous potential for this purpose. In the present study, this principle was applied to titanium, a common material in implantology, and its biofilm-repellent properties were demonstrated...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28229220/overexpression-of-hepacam-inhibits-bladder-cancer-cell-proliferation-and-viability-through-the-akt-foxo-pathway
#8
Min Tang, Yan Zhao, Nanjing Liu, E Chen, Zhen Quan, Xiaohou Wu, Chunli Luo
PURPOSE: HepaCAM, an N-linked glycoprotein that encodes a member of the immunoglobulin superfamily, has been reported to be a tumor suppressor gene that mediates diverse cellular bio-functions. Recent studies have shown that the FoxO transcription factors play a pivotal role during cancer progression. Here, we explored the correlation between HepaCAM and the FoxO family via regulation of the PI3K/AKT pathway. METHODS: HepaCAM and FoxO3 expression were detected by immunohistochemistry staining...
February 22, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28229212/the-effect-of-a-cyclic-uniaxial-strain-on-urinary-bladder-cells
#9
Dorien Tiemessen, Paul de Jonge, Willeke Daamen, Wout Feitz, Paul Geutjes, Egbert Oosterwijk
PURPOSE: Pre-conditioning of a cell seeded construct may improve the functional outcome of a tissue engineered construct for augmentation cystoplasty. The precise effects of mechanical stimulation on urinary bladder cells in vitro are not clear. In this study we investigate the effect of a cyclic uniaxial strain culture on urinary bladder cells which were seeded on a type I collagen scaffold. METHODS: Isolated porcine smooth muscle cells or urothelial cells were seeded on a type I collagen scaffolds and cultured under static and dynamic conditions...
February 23, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28228292/a-fresh-look-at-bioresorbable-scaffold-technology-intuition-pumps
#10
EDITORIAL
Sundeep Mishra
Bioresorbable scaffolds (BRS) are a new enticing treatment option in coronary interventions. Absorb BVS™ Is the most widely used and researched polymer based BRS, eluting everolimus. However currently it has several technical limitations; low radial support, larger strut size, poor visualization, poor deliverability and complex implantation technique. Magnesium based BRS are an alternate but they are also limited not only by lower radial support and poor visualization but also earlier bio-absorption. Material processing: blow-molding, annealing, polymer orientation, change in composition and use of higher molecular weight polymer, as well new polymers like tyrosine or salicyclate analogs and even hybrid (polymer and metallic) combined with intelligent cell design has led to evolution of BRS technology...
January 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28228088/aryl-heteroaryl-substituted-celecoxib-derivatives-as-cox-2-inhibitors-synthesis-anti-inflammatory-activity-and-molecular-docking-studies
#11
Golla Madhava, Katla Venkata Ramana, Saddala Madhu Sudhana, Devineni Subba Rao, Kuntrapakam Hema Kumar, Valluru Lokanatha, Asupatri Usha Rani, Chamarthi Naga Raju
BACKGROUND: Cyclooxygenase (COX-2) inhibitors have been developed to provide better anti-inflammatory and analgesic efficacy than those of traditional NSAIDs. Several compounds having selective COX-2 inhibitors such as SC-558, Celecoxib, Rofecoxib, Valdecoxib and Etoricoxib are marketed as new generation NSAIDs and block the production of prostaglandins (PGs) in inflammatory cells. New anti-inflammatory dynamic agents with improved potency and safety profile are still needed. OBJECTIVE: As a part of our continuation research work towards the synthesis of anti-inflammatory agents, the synthesis of N-substituted aryl/heteroaryl-pyrazole-1yl benzene sulfonamide (Celecoxib) derivatives, and evaluated their anti-inflammatory activity in both methods in vitro and in vivo, and molecular docking study on COX-2 enzyme will be discussed in this study...
February 20, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28228081/the-neurobiology-and-psychiatric-perspective-of-vaginismus-linking-the-pharmacological-and-psycho-social-interventions
#12
Zuri Shahidii Kadir, Hatta Sidi, Jaya Kumar, Srijit Das, Marhani Midin, Najwa Baharuddin
Vaginismus is an involuntary muscle contraction of the outer third of vaginal barrel causing sexual penetration almost impossible. It is generally classified under sexual pain disorder (SPD). In Diagnostic and Statistical Manual, 5th edition, it is classified under the new rubric of Genito-Pelvic Pain/Sexual Penetration Disorder. This fear-avoidance condition poses an ongoing significant challenge to the medical and health professionals due to the very demanding needs in health care despite its unpredictable prognosis...
February 22, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28228013/highly-efficient-and-safe-delivery-of-vegf-sirna-by-bio-reducible-fluorinated-peptide-dendrimers-for-cancer-therapy
#13
Xiaojun Cai, Haofang Zhu, Yanmei Zhang, Zhongwei Gu
RNA interference (RNAi) hold great promise in treating a wide range of diseases. However, it remains highly desirable to develop new delivery systems to circumvent complex extra- and intracellular barriers for successful clinical translation. Here, we report on a versatile polymeric vector, bio-reducible fluorinated peptide dendrimers (BFPD), for highly efficient and safe delivery of siRNA. In virtue of skillfully integrated all of the unique features of reversible cross-linking, fluorination and peptide dendrimers, this novel vector can surmount almost all extra- and intracellular barriers associated with local siRNA delivery through highly improved physiological stability and serum resistance, significantly increased intratumoral enrichment, cellular uptake, as well as successful facilitation of endosomal escape and cytosolic siRNA release...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28227949/wrist-worn-heartbeat-monitoring-system-based-on-bio-impedance-analysis
#14
Jia Xu, Xiaomeng Gao, Alexander Lee, Shuhei Yamada, Ehsan Yavari, Victor Lubecke, Olga Boric-Lubecke, Jia Xu, Xiaomeng Gao, Alexander Lee, Shuhei Yamada, Ehsan Yavari, Victor Lubecke, Olga Boric-Lubecke, Olga Boric-Lubecke, Xiaomeng Gao, Shuhei Yamada, Ehsan Yavari, Jia Xu, Victor Lubecke, Alexander Lee
In this paper, a bio-impedance analysis (BIA) based wrist-worn heartbeat monitoring system is proposed. The system is able to estimate heart rate from a subject's wrist with only four electrodes. The design is achieved with a standard BIA device and off-the-shelf components for signal conditioning. The measured heartbeat-related impedance signal is compared with a reference heart rate signal obtained from piezoelectric finger pulse transducer. The BIA results agree with the reference, which validates the feasibility of the proposed system...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227911/an-implementation-for-the-simulation-of-cells-on-micro-post-arrays
#15
Duy T Truong, Christian Bahls, Barbara Nebe, Ursula van Rienen, Duy T Truong, Christian Bahls, Barbara Nebe, Ursula van Rienen, Duy T Truong, Christian Bahls, Ursula van Rienen, Barbara Nebe
The mechanical interaction between cells and their underlying substrates is important in understanding the processes that take place at an interface between biological tissue and the surface of implants. There have been numerous studies that examine these interactions both by experimental and numerical modeling. The bio-chemo-mechanical model for cell contractility by Deshpande et al. [1] has numerous applications and advantages. This work shows a way to implement this model in COMSOL MULTIPHYSICS® so it can be easily modified or extended...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227908/a-boolean-approach-to-bacterial-chemotaxis
#16
Anuj Deshpande, Sibendu Samanta, Haimabati Das, Ritwik Kumar Layek, Anuj Deshpande, Sibendu Samanta, Haimabati Das, Ritwik Kumar Layek, Sibendu Samanta, Anuj Deshpande, Haimabati Das, Ritwik Kumar Layek
Bacterium such as Escherichia coli (E. coli) show biased Brownian motion in different chemical concentration gradients. This chemical sensitive motility or chemotaxis has gained considerable interest among scientists for some remarkable features such as chemo-sensory dynamic range, adaptation, diffusion and drift. A Boolean model of the whole chemotaxis process has been developed in this manuscript. The response of the circuit is in accordance with the experimental results available in the literature, providing indirect validation of the model...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227584/design-of-a-wearable-bio-patch-for-monitoring-patient-s-temperature
#17
Jose M Vicente, Ernesto Avila-Navarro, Carlos G Juan, Nicolas Garcia, Jose M Sabater-Navarro, Jose M Vicente, Ernesto Avila-Navarro, Carlos G Juan, Nicolas Garcia, Jose M Sabater-Navarro, Jose M Vicente, Carlos G Juan, Nicolas Garcia, Ernesto Avila-Navarro, Jose M Sabater-Navarro
New communication technologies allow us developing useful and more practical medical applications, in particular for ambulatory monitoring. NFC communication has the advantages of low powering and low influence range area, what makes this technology suitable for health applications. This work presents an explanation of the design process of planar NFC antennas in a wearable biopatch. The problem of optimizing the communication distance is addressed. Design of a biopatch for continuous temperature monitoring and experimental results obtained wearing this biopatch during daily activities are presented...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227569/efficient-compressive-sensing-of-ecg-segments-based-on-machine-learning-for-qrs-based-arrhythmia-detection
#18
Jeevan K Pant, Sridhar Krishnan, Jeevan K Pant, Sridhar Krishnan, Jeevan K Pant, Sridhar Krishnan
A novel method for efficient telemonitoring of arrhythmia based on using QRS complexes is proposed. Two features, namely, sum of absolute differences (SAD) and maximum of absolute differences (MAD) are efficiently computed for each ECG segment in the bio-sensor. The computed features can be transmitted from the bio-sensor using wireless channel, and they can be used in the receiver for determining the absence of QRS complex in the segment. By avoiding computationally expensive signal reconstruction for the ECG segments without QRS complex, it is shown, using simulation results, that computation time can be reduced by approximately 7...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227469/building-a-more-diverse-biomedical-engineering-workforce-biomedical-engineering-at-the-university-of-the-district-of-columbia-a-historically-black-college-university
#19
Lara A Thompson, A Segun Adebayo, Nian Zhang, Sasan Haghani, Kathleen Dowell, Devdas Shetty, Lara A Thompson, A Segun Adebayo, Nian Zhang, Sasan Haghani, Kathleen Dowell, Devdas Shetty, A Segun Adebayo, Sasan Haghani, Kathleen Dowell, Lara A Thompson, Devdas Shetty, Nian Zhang
Biomedical Engineering (BME) is a new, multidisciplinary, and rapidly growing field, however, the BME Workforce suffers from limited ethnic and gender diversity. Despite the demand and growth of this new field due to its public health importance, only 4 out of the 107 Historically Black Colleges and Universities (HBCUs) nationwide offers a Bachelor's of Science (B.S.) in Bio-Engineering related fields. In order to contribute to a growing BME Workforce, HBCUs need to react and offer more degree-programs relevant to BME...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227431/bio-active-polymer-implants-to-adipose-tissue-as-in-situ-source-of-reprogramming-cells
#20
Andrey Mikhailov, Fumihiro Sugiyama, Saori Mizuno, Yoshiyuki Sankai, Andrey Mikhailov, Fumihiro Sugiyama, Saori Mizuno, Yoshiyuki Sankai, Saori Mizuno, Andrey Mikhailov, Fumihiro Sugiyama, Yoshiyuki Sankai
The implants from natural polymer chitosan was developed by sorption of non-viral DNA vector. These assemblies were shown to be biocompatible and able to transfect the surrounding cells with reprogramming factors. Transgenic rats from the strain allowing visualization of Nanog-positive stem cells received these implants into their adipose deposits. After 8 days we were able to detect in situ-transfected cells. Transfected cells were positive for YFP fluorescence and transiently expressed the markers correlating with stemness...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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