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Paramyxovirus

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https://www.readbyqxmd.com/read/28809150/a-tupaia-paramyxovirus-vector-system-for-targeting-and-transgene-expression
#1
Christine E Engeland, Sascha Bossow, Andrew W Hudacek, Birgit Hoyler, Judith Förster, Rūta Veinalde, Dirk Jäger, Roberto Cattaneo, Guy Ungerechts, Christoph Springfeld
Viruses from the diverse family of Paramyxoviridae include important pathogens and are applied in gene therapy and for cancer treatment. The Tupaia paramyxovirus (TPMV), isolated from the kidney of a tree shrew, does not infect human cells and neutralizing antibodies against other Paramyxoviridae do not cross-react with TPMV. Here, we present a vector system for de novo generation of infectious TPMV that allows for insertion of additional genes as well as targeting using antibody single-chain variable fragments...
August 15, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28767708/physiological-stress-and-hendra-virus-in-flying-foxes-pteropus-spp-australia
#2
Lee McMichael, Daniel Edson, Craig Smith, David Mayer, Ina Smith, Steven Kopp, Joanne Meers, Hume Field
Pteropid bats (flying-foxes) are the natural reservoir of Hendra virus, an emergent paramyxovirus responsible for fatal infection in horses and humans in Australia. Pteropus alecto (the Black flying-fox) and the paraphyletic P. conspicillatus (the Spectacled flying-fox) appear to be the primary reservoir hosts. Previous studies have suggested that physiological and ecological factors may underpin infection dynamics in flying-foxes, and subsequent spillover to horses and in turn humans. We sought to examine temporal trends in urinary cortisol concentration in wild Australian flying-fox populations, to elucidate the putative relationship between Hendra virus infection and physiological stress...
2017: PloS One
https://www.readbyqxmd.com/read/28749283/seroprevalence-and-molecular-characterization-of-ferlavirus-in-captive-vipers-of-costa-rica
#3
Cristina Solis, Randall Arguedas, Mario Baldi, Martha Piche, Carlos Jimenez
Ferlaviruses (FV, previously referred to as ophidian paramyxoviruses, OPMV), are enveloped viruses with a negative-strand RNA genome, affecting snakes in captivity worldwide. Infection is characterized by respiratory and nervous clinical signs and carries high mortality rates, but no specific treatment or vaccine is currently available. Costa Rica has 16 species of vipers, found in captivity in collections essential for antivenom production, reintroduction, and public education. FV circulation in these populations was previously unknown, and the risk of introducing the viruses into naïve collections or free-ranging populations exists if the virus's presence is confirmed...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28714870/antiviral-lipopeptide-cell-membrane-interaction-is-influenced-by-peg-linker-length
#4
Marcelo T Augusto, Axel Hollmann, Matteo Porotto, Anne Moscona, Nuno C Santos
A set of lipopeptides was recently reported for their broad-spectrum antiviral activity against viruses belonging to the Paramyxoviridae family, including human parainfluenza virus type 3 and Nipah virus. Among them, the peptide with a 24-unit PEG linker connecting it to a cholesterol moiety (VG-PEG24-Chol) was found to be the best membrane fusion inhibitory peptide. Here, we evaluated the interaction of the same set of peptides with biomembrane model systems and isolated human peripheral blood mononuclear cells (PBMC)...
July 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28710271/novel-alphacoronaviruses-and-paramyxoviruses-co-circulate-with-type-1-and-sars-related-betacoronaviruses-in-synanthropic-bats-in-luxembourg
#5
Maude Pauly, Jacques B Pir, Catherine Loesch, Aurélie Sausy, Chantal J Snoeck, Judith M Hübschen, Claude P Muller
Several infectious disease outbreaks with high mortality in humans have been attributed to viruses that are thought to have evolved from bat viruses. In this study from Luxembourg, the genetic diversity and epidemiology of paramyxoviruses and coronaviruses shed by the bat species Rhinolophus ferrumequinum and Myotis emarginatus was evaluated. Faeces collection (n= 624) was performed longitudinally in a mixed-species colony in 2015 and 2016. In addition, faeces (n= 254) were collected cross-sectionally from six Myotis emarginatus colonies in 2016...
July 14, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28686568/comparing-viral-metagenomic-extraction-methods
#6
Jeanette Klenner, Claudia Kohl, Piotr Wojtek Dabrowski, Andreas Nitsche
A crucial step in the molecular detection of viruses in clinical specimens is the efficient extraction of viral nucleic acids. The total yield of viral nucleic acid from a clinical specimen is dependent on the specimen's volume, the initial virus concentration and the effectiveness provided by the extraction method. Recent Next Generation Sequencing (NGS)-based diagnostic approaches (i.e. metagenomics) provide a molecular 'open view' into the sample, as they theoretically generate sequence reads of any nucleic acid present in a specimen in a statistically representative manner...
July 6, 2017: Current Issues in Molecular Biology
https://www.readbyqxmd.com/read/28685285/evaluation-of-the-replication-and-pathogenicity-of-a-variant-avian-paramyxovirus-serotype-6-in-mice
#7
Vuong Nghia Bui, Dai Quang Trinh, Lary N B Abao, Yuki Ozeki, Jonathan Runstadler, Kikuyasu Nakamura, Haruko Ogawa, Kunitoshi Imai
Avian paramyxoviruses (APMVs) have been evaluated for their potential use as vaccine vectors, sparking research efforts leading to a better understanding of APMVs' replication and pathogenicity. However, within APMV serotypes, significant genetic diversity exists, and the infectivity of variant strains in mammals has not been studied. We utilized a mouse model to evaluate the pathogenicity of a variant strain of APMV-6 (APMV-6/red-necked stint/Japan/8KS0813/2008) in comparison with the prototype APMV-6 strain (APMV-6/duck/Hong Kong/18/199/1977)...
July 6, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28665727/characterization-and-epidemiology-of-pigeon-paramyxovirus-type-1-viruses-ppmv-1-isolated-in-macedonia
#8
A Dodovski, I Cvetkovikj, K Krstevski, I Naletoski, Vladimir Savić
We have characterized in this study 10 PPMV-1 isolated from domestic pigeons and one PPMV-1 isolated from a feral pigeon in the period 2007-2012, using both classical methods (HI test and ICPI test) and molecular methods (RT-qPCR, RT-PCR, and nucleotide sequencing). Using phylogenetic analysis of partial fusion gene sequences, these viruses clustered with recent European PPMV-1 isolates (EU/re) within the genotype VIb/1. All isolates possessed virulent cleavage site motifs with variable morbidity and mortality in pigeons...
June 2017: Avian Diseases
https://www.readbyqxmd.com/read/28651549/6-methylmercaptopurine-riboside-a-thiopurine-nucleoside-with-antiviral-activity-against-canine-distemper-virus-in-vitro
#9
Otávio Valério de Carvalho, Daniele Mendes Félix, Claudia de Camargo Tozato, Juliana Lopes Rangel Fietto, Márcia Rogéria de Almeida, Gustavo Costa Bressan, Lindomar José Pena, Abelardo Silva-Júnior
BACKGROUND: Canine distemper (CD) is a widespread infectious disease that can severely impact a variety of species in the order Carnivora, as well as non-carnivore species such as non-human primates. Despite large-scale vaccination campaigns, several fatal outbreaks have been reported in wild and domestic carnivore populations. This, in association with expansion of the disease host range and the development of vaccine-escape strains, has contributed to an increased demand for therapeutic strategies synergizing with vaccine programs for effectively controlling canine distemper...
June 26, 2017: Virology Journal
https://www.readbyqxmd.com/read/28636633/playing-with-fire-what-is-influencing-horse-owners-decisions-to-not-vaccinate-their-horses-against-deadly-hendra-virus-infection
#10
Kailiea Arianna Goyen, John David Wright, Alexandra Cunneen, Joerg Henning
Hendra virus is a zoonotic paramyxovirus, which causes severe respiratory and neurological disease in horses and humans. Since 2012, the Hendra virus sub-unit G vaccine has been available for horse vaccination in Australia. Uptake of the vaccine has been limited and spill-over events of Hendra virus infection in horses continue to occur. We conducted an online, questionnaire-based cross-sectional study of 376 horse owners belonging to a variety of different equestrian clubs in Queensland, Australia, to identify risk factors for non-vaccination against Hendra virus...
2017: PloS One
https://www.readbyqxmd.com/read/28629988/4-azidocytidine-r1479-inhibits-henipaviruses-and-other-paramyxoviruses-with-high-potency
#11
Anne L Hotard, Biao He, Stuart T Nichol, Christina F Spiropoulou, Michael K Lo
The henipaviruses Nipah virus and Hendra virus are highly pathogenic zoonotic paramyxoviruses which have caused fatal outbreaks of encephalitis and respiratory disease in humans. Despite the availability of a licensed equine Hendra virus vaccine and a neutralizing monoclonal antibody shown to be efficacious against henipavirus infections in non-human primates, there remains no approved therapeutics or vaccines for human use. To explore the possibility of developing small-molecule nucleoside inhibitors against henipaviruses, we evaluated the antiviral activity of 4'-azidocytidine (R1479), a drug previously identified to inhibit flaviviruses, against henipaviruses along with other representative members of the family Paramyxoviridae...
June 17, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28616484/climatic-suitability-influences-species-specific-abundance-patterns-of-australian-flying-foxes-and-risk-of-hendra-virus-spillover
#12
Gerardo A Martin, Carlos Yanez-Arenas, Billie J Roberts, Carla Chen, Raina K Plowright, Rebecca J Webb, Lee F Skerratt
Hendra virus is a paramyxovirus of Australian flying fox bats. It was first detected in August 1994, after the death of 20 horses and one human. Since then it has occurred regularly within a portion of the geographical distribution of all Australian flying fox (fruit bat) species. There is, however, little understanding about which species are most likely responsible for spillover, or why spillover does not occur in other areas occupied by reservoir and spillover hosts. Using ecological niche models of the four flying fox species we were able to identify which species are most likely linked to spillover events using the concept of distance to the niche centroid of each species...
December 2016: One Health
https://www.readbyqxmd.com/read/28603697/dispersal-and-transmission-of-avian-paramyxovirus-serotype-4-among-wild-birds-and-domestic-poultry
#13
Renfu Yin, Pingze Zhang, Xinxin Liu, Yanyu Chen, Zhi Tao, Lili Ai, Junjiao Li, Yingying Yang, Mingxin Li, Cong Xue, Jing Qian, Xueli Wang, Jing Chen, Yong Li, Yanping Xiong, Jun Zhang, Tobias Stoeger, Yuhai Bi, Jianjun Chen, Zhuang Ding
Avian paramyxovirus serotype 4 (APMV-4) is found sporadically in wild birds worldwide, and it is an economically important poultry pathogen. Despite the existence of several published strains, very little is known about the distribution, host species, and transmission of APMV-4 strains. To better understand the relationships among these factors, we conducted an APMV-4 surveillance of wild birds and domestic poultry in six provinces of China suspected of being intercontinental flyways and sites of interspecies transmission...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28601688/structure-and-organization-of-paramyxovirus-particles
#14
REVIEW
Robert M Cox, Richard K Plemper
The paramyxovirus family comprises major human and animal pathogens such as measles virus (MeV), mumps virus (MuV), the parainfluenzaviruses, Newcastle disease virus (NDV), and the highly pathogenic zoonotic hendra (HeV) and nipah (NiV) viruses. Paramyxovirus particles are pleomorphic, with a lipid envelope, nonsegmented RNA genomes of negative polarity, and densely packed glycoproteins on the virion surface. A number of crystal structures of different paramyxovirus proteins and protein fragments were solved, but the available information concerning overall virion organization remains limited...
June 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28600653/how-order-and-disorder-within-paramyxoviral-nucleoproteins-and-phosphoproteins-orchestrate-the-molecular-interplay-of-transcription-and-replication
#15
REVIEW
Sonia Longhi, Louis-Marie Bloyet, Stefano Gianni, Denis Gerlier
In this review, we summarize computational and experimental data gathered so far showing that structural disorder is abundant within paramyxoviral nucleoproteins (N) and phosphoproteins (P). In particular, we focus on measles, Nipah, and Hendra viruses and highlight both commonalities and differences with respect to the closely related Sendai virus. The molecular mechanisms that control the disorder-to-order transition undergone by the intrinsically disordered C-terminal domain (NTAIL) of their N proteins upon binding to the C-terminal X domain (XD) of the homologous P proteins are described in detail...
September 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28597087/phylogenetic-and-pathogenic-characterization-of-a-pigeon-paramyxovirus-type-1-isolate-reveals-cross-species-transmission-and-potential-outbreak-risks-in-the-northwest-region-of-china
#16
Shanhui Ren, Chongyang Wang, Xue Zhang, Lei Zhao, Xiangwei Wang, Wei Yao, Qingsong Han, Yanhong Wang, Mengfei Fan, Xiaolong Gao, Sa Xiao, Xinglong Wang, Zengqi Yang
Pigeon paramyxovirus type-1 (PPMV-1) is enzootic in pigeons, causing severe economic loss in the poultry industry in many countries. However, the exact epidemic process of PPMV-1 transmission is still unclear. In this study, we analyzed the complete genome of the PPMV-1/SX-01/15 isolate. Sequence results show that the virus genome contains 15,192 nucleotides, with the gene order 3'-NP-P-M-F-HN-L-5'. Phylogenetic analysis revealed that this genome belongs to subgenotype VIc in class II. The mean death time (MDT) and intracerebral pathogenicity index (ICPI) were 62...
June 8, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28595094/two-plasmid-system-to-increase-the-rescue-efficiency-of-paramyxoviruses-by-reverse-genetics-the-example-of-rescuing-newcastle-disease-virus
#17
Haijin Liu, Emmanuel Albina, Patricia Gil, Cécile Minet, Renata Servan de Almeida
Within paramyxoviruses, conventional reverse genetics require the transfection of a minimum of four plasmids: three to reconstruct the viral polymerase complex that replicates and expresses the virus genome delivered by a fourth plasmid. The successful transfection of four or more plasmids of different sizes into one cell and the subsequent generation of at least one viable and replicable viral particle is a rare event, which explains the low rescue efficiency, especially of low virulent viruses with reduced replication efficiency in cell lines...
September 2017: Virology
https://www.readbyqxmd.com/read/28592541/dimerization-efficiency-of-canine-distemper-virus-matrix-protein-regulates-membrane-budding-activity
#18
Fanny Bringolf, Michael Herren, Marianne Wyss, Beatriz Vidondo, Johannes P Langedijk, Andreas Zurbriggen, Philippe Plattet
Paramyxoviruses rely on the matrix (M) protein to orchestrate viral assembly and budding at the plasma membrane. Although the mechanistic details remain largely unknown, structural data suggested that M dimers and/or higher-order oligomers may facilitate membrane budding. To gain functional insights, we employed a structure-guided mutagenesis approach to investigate the role of canine distemper virus (CDV) M protein self-assembly in membrane-budding activity. Three six-alanine-block (6A-block) mutants with mutations located at strategic oligomeric positions were initially designed...
August 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28592535/newcastle-disease-virus-establishes-persistent-infection-in-tumor-cells-in-vitro-contribution-of-the-cleavage-site-of-fusion-protein-and-second-sialic-acid-binding-site-of-hemagglutinin-neuraminidase
#19
Udaya S Rangaswamy, Weijia Wang, Xing Cheng, Patrick McTamney, Danielle Carroll, Hong Jin
Newcastle disease virus (NDV) is an oncolytic virus being developed for the treatment of cancer. Following infection of a human ovarian cancer cell line (OVCAR3) with a recombinant low-pathogenic NDV, persistent infection was established in a subset of tumor cells. Persistently infected (PI) cells exhibited resistance to superinfection with NDV and established an antiviral state, as demonstrated by upregulation of interferon and interferon-induced genes such as myxoma resistance gene 1 (Mx1) and retinoic acid-inducing gene-I (RIG-I)...
August 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28589292/detection-of-diverse-viruses-in-alimentary-specimens-of-bats-in-macau
#20
Jie Liang, Xing-Lou Yang, Bei Li, Qi Liu, Qin Zhang, Hui Liu, Hon-Pio Kan, Kai-Chin Wong, Si-Nga Chek, Xiangyang He, Xingwen Peng, Zheng-Li Shi, Yi Wu, Libiao Zhang
Bats carry a variety of viruses, and some of them cause public health problems. Macau, which is famous for its gambling industry, has a complex population structure. The globalization in such an international metropolis has enhanced the chance of disease transmission. Therefore, surveillance of zoonotic viruses is necessary for the early warning of potential emerging infectious diseases. Here, we report the first surveillance of bat viruses in Macau. In this study, we collected 1004 samples involving 10 bat species from 7 sites from April 2015 to May 2016, and examined the presence of viruses using nucleic acid-based methods...
June 2017: Virologica Sinica
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