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Paramyxovirus

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https://www.readbyqxmd.com/read/28636633/playing-with-fire-what-is-influencing-horse-owners-decisions-to-not-vaccinate-their-horses-against-deadly-hendra-virus-infection
#1
Kailiea Arianna Goyen, John David Wright, Alexandra Cunneen, Joerg Henning
Hendra virus is a zoonotic paramyxovirus, which causes severe respiratory and neurological disease in horses and humans. Since 2012, the Hendra virus sub-unit G vaccine has been available for horse vaccination in Australia. Uptake of the vaccine has been limited and spill-over events of Hendra virus infection in horses continue to occur. We conducted an online, questionnaire-based cross-sectional study of 376 horse owners belonging to a variety of different equestrian clubs in Queensland, Australia, to identify risk factors for non-vaccination against Hendra virus...
2017: PloS One
https://www.readbyqxmd.com/read/28629988/4-azidocytidine-r1479-inhibits-henipaviruses-and-other-paramyxoviruses-with-high-potency
#2
Anne L Hotard, Biao He, Stuart T Nichol, Christina F Spiropoulou, Michael K Lo
The henipaviruses Nipah virus and Hendra virus are highly pathogenic zoonotic paramyxoviruses which have caused fatal outbreaks of encephalitis and respiratory disease in humans. Despite the availability of a licensed equine Hendra virus vaccine and a neutralizing monoclonal antibody shown to be efficacious against henipavirus infections in non-human primates, there remains no approved therapeutics or vaccines for human use. To explore the possibility of developing small-molecule nucleoside inhibitors against henipaviruses, we evaluated the antiviral activity of 4'-azidocytidine (R1479), a drug previously identified to inhibit flaviviruses, against henipaviruses along with other representative members of the family Paramyxoviridae...
June 17, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28616484/climatic-suitability-influences-species-specific-abundance-patterns-of-australian-flying-foxes-and-risk-of-hendra-virus-spillover
#3
Gerardo A Martin, Carlos Yanez-Arenas, Billie J Roberts, Carla Chen, Raina K Plowright, Rebecca J Webb, Lee F Skerratt
Hendra virus is a paramyxovirus of Australian flying fox bats. It was first detected in August 1994, after the death of 20 horses and one human. Since then it has occurred regularly within a portion of the geographical distribution of all Australian flying fox (fruit bat) species. There is, however, little understanding about which species are most likely responsible for spillover, or why spillover does not occur in other areas occupied by reservoir and spillover hosts. Using ecological niche models of the four flying fox species we were able to identify which species are most likely linked to spillover events using the concept of distance to the niche centroid of each species...
December 2016: One Health
https://www.readbyqxmd.com/read/28603697/dispersal-and-transmission-of-avian-paramyxovirus-serotype-4-among-wild-birds-and-domestic-poultry
#4
Renfu Yin, Pingze Zhang, Xinxin Liu, Yanyu Chen, Zhi Tao, Lili Ai, Junjiao Li, Yingying Yang, Mingxin Li, Cong Xue, Jing Qian, Xueli Wang, Jing Chen, Yong Li, Yanping Xiong, Jun Zhang, Tobias Stoeger, Yuhai Bi, Jianjun Chen, Zhuang Ding
Avian paramyxovirus serotype 4 (APMV-4) is found sporadically in wild birds worldwide, and it is an economically important poultry pathogen. Despite the existence of several published strains, very little is known about the distribution, host species, and transmission of APMV-4 strains. To better understand the relationships among these factors, we conducted an APMV-4 surveillance of wild birds and domestic poultry in six provinces of China suspected of being intercontinental flyways and sites of interspecies transmission...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28601688/structure-and-organization-of-paramyxovirus-particles
#5
REVIEW
Robert M Cox, Richard K Plemper
The paramyxovirus family comprises major human and animal pathogens such as measles virus (MeV), mumps virus (MuV), the parainfluenzaviruses, Newcastle disease virus (NDV), and the highly pathogenic zoonotic hendra (HeV) and nipah (NiV) viruses. Paramyxovirus particles are pleomorphic, with a lipid envelope, nonsegmented RNA genomes of negative polarity, and densely packed glycoproteins on the virion surface. A number of crystal structures of different paramyxovirus proteins and protein fragments were solved, but the available information concerning overall virion organization remains limited...
June 8, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28600653/how-order-and-disorder-within-paramyxoviral-nucleoproteins-and-phosphoproteins-orchestrate-the-molecular-interplay-of-transcription-and-replication
#6
REVIEW
Sonia Longhi, Louis-Marie Bloyet, Stefano Gianni, Denis Gerlier
In this review, we summarize computational and experimental data gathered so far showing that structural disorder is abundant within paramyxoviral nucleoproteins (N) and phosphoproteins (P). In particular, we focus on measles, Nipah, and Hendra viruses and highlight both commonalities and differences with respect to the closely related Sendai virus. The molecular mechanisms that control the disorder-to-order transition undergone by the intrinsically disordered C-terminal domain (NTAIL) of their N proteins upon binding to the C-terminal X domain (XD) of the homologous P proteins are described in detail...
June 9, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28597087/phylogenetic-and-pathogenic-characterization-of-a-pigeon-paramyxovirus-type-1-isolate-reveals-cross-species-transmission-and-potential-outbreak-risks-in-the-northwest-region-of-china
#7
Shanhui Ren, Chongyang Wang, Xue Zhang, Lei Zhao, Xiangwei Wang, Wei Yao, Qingsong Han, Yanhong Wang, Mengfei Fan, Xiaolong Gao, Sa Xiao, Xinglong Wang, Zengqi Yang
Pigeon paramyxovirus type-1 (PPMV-1) is enzootic in pigeons, causing severe economic loss in the poultry industry in many countries. However, the exact epidemic process of PPMV-1 transmission is still unclear. In this study, we analyzed the complete genome of the PPMV-1/SX-01/15 isolate. Sequence results show that the virus genome contains 15,192 nucleotides, with the gene order 3'-NP-P-M-F-HN-L-5'. Phylogenetic analysis revealed that this genome belongs to subgenotype VIc in class II. The mean death time (MDT) and intracerebral pathogenicity index (ICPI) were 62...
June 8, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28595094/two-plasmid-system-to-increase-the-rescue-efficiency-of-paramyxoviruses-by-reverse-genetics-the-example-of-rescuing-newcastle-disease-virus
#8
Haijin Liu, Emmanuel Albina, Patricia Gil, Cécile Minet, Renata Servan de Almeida
Within paramyxoviruses, conventional reverse genetics require the transfection of a minimum of four plasmids: three to reconstruct the viral polymerase complex that replicates and expresses the virus genome delivered by a fourth plasmid. The successful transfection of four or more plasmids of different sizes into one cell and the subsequent generation of at least one viable and replicable viral particle is a rare event, which explains the low rescue efficiency, especially of low virulent viruses with reduced replication efficiency in cell lines...
June 5, 2017: Virology
https://www.readbyqxmd.com/read/28592541/dimerization-efficiency-of-canine-distemper-virus-matrix-protein-regulates-membrane-budding-activity
#9
Fanny Bringolf, Michael Herren, Marianne Wyss, Beatriz Vidondo, Johannes P Langedijk, Andreas Zurbriggen, Philippe Plattet
Paramyxoviruses rely on the matrix (M) protein to orchestrate viral assembly and budding at the plasma membrane. Although mechanistic details remain largely unknown, structural data suggested that M dimers and/or higher oligomers may facilitate membrane budding. To gain functional insights, we here employed a structure-guided mutagenesis approach to investigate the role of canine distemper virus (CDV) M protein self-assembly in membrane budding activity. Three six-alanine-scan (6A) block mutants, locating at strategic oligomeric positions, were initially designed...
June 7, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28592535/newcastle-disease-virus-establishes-persistent-infection-in-tumor-cells-in-vitro-contribution-of-the-cleavage-site-of-fusion-protein-and-second-sialic-acid-binding-site-of-hemagglutinin-neuraminidase
#10
Udaya S Rangaswamy, Weijia Wang, Xing Cheng, Patrick McTamney, Danielle Carroll, Hong Jin
Newcastle Disease Virus (NDV) is an oncolytic virus being developed for the treatment of cancer. Following infection of an ovarian human cancer cell line (OVCAR3) with a recombinant low pathogenic NDV, persistent infection (PI) was established in a subset of tumor cells. PI cells exhibited resistance to superinfection with NDV, and an anti-viral state as demonstrated by upregulation of interferon and interferon induced genes such as Myxoma resistance gene 1 (Mx1) and Retinoic acid-inducing gene-I (RIG-I). Viruses released from PI cells induced higher cell to cell fusion following infection compared to the parental virus in two tumor cell lines tested, HT1080 and HeLa, and remained to be attenuated in chickens...
June 7, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28589292/detection-of-diverse-viruses-in-alimentary-specimens-of-bats-in-macau
#11
Jie Liang, Xing-Lou Yang, Bei Li, Qi Liu, Qin Zhang, Hui Liu, Hon-Pio Kan, Kai-Chin Wong, Si-Nga Chek, Xiangyang He, Xingwen Peng, Zheng-Li Shi, Yi Wu, Libiao Zhang
Bats carry a variety of viruses, and some of them cause public health problems. Macau, which is famous for its gambling industry, has a complex population structure. The globalization in such an international metropolis has enhanced the chance of disease transmission. Therefore, surveillance of zoonotic viruses is necessary for the early warning of potential emerging infectious diseases. Here, we report the first surveillance of bat viruses in Macau. In this study, we collected 1004 samples involving 10 bat species from 7 sites from April 2015 to May 2016, and examined the presence of viruses using nucleic acid-based methods...
June 1, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28572332/complete-genome-sequences-of-four-avian-paramyxoviruses-of-serotype-10-isolated-from-rockhopper-penguins-on-the-falkland-islands
#12
Iryna V Goraichuk, Kiril M Dimitrov, Poonam Sharma, Patti J Miller, David E Swayne, David L Suarez, Claudio L Afonso
The first complete genome sequences of four avian paramyxovirus serotype 10 (APMV-10) isolates are described here. The viruses were isolated from rockhopper penguins on the Falkland Islands, sampled in 2007. All four genomes are 15,456 nucleotides in length, and phylogenetic analyses show them to be closely related.
June 1, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28539439/contribution-of-human-lung-parenchyma-and-leukocyte-influx-to-oxidative-stress-and-immune-mediated-pathology-following-nipah-infection
#13
Olivier Escaffre, Tais B Saito, Terry L Juelich, Tetsuro Ikegami, Jennifer K Smith, David D Perez, Colm Atkins, Corri B Levine, Matthew B Huante, Rebecca J Nusbaum, Janice J Endsley, Alexander N Freiberg, Barry Rockx
Nipah virus (NiV) is a zoonotic emerging paramyxovirus that can cause a fatal respiratory illness or encephalitis in humans. Despite many efforts, the molecular mechanisms of NiV-induced acute lung injury (ALI) remain unclear. We previously showed that NiV replicates to high titers in human lung grafts in NOD scid gamma mice, resulting in a robust inflammatory response. Interestingly, these mice can undergo human immune system reconstitution by the Bone marrow, Liver, and Thymus (BLT) reconstitution method, in addition to lung tissue engraftment, giving altogether a realistic model to study human respiratory viral infections...
May 24, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28533052/reverse-spillover-of-avian-viral-vaccine-strains-from-domesticated-poultry-to-wild-birds
#14
M A Rohaim, R F El Naggar, A M Helal, H A Hussein, Muhammad Munir
Transmission of viruses from the commercial poultry to wild birds is an emerging paradigm of livestock-wildlife interface. Here, we report the identification and isolation of vaccine strains of avian paramyxovirus serotype 1 (APMV1) and avian coronaviruses (ACoV) from different wild bird species across eight Egyptian governorates between January 2014 and December 2015. Surveillance of avian respiratory viruses in free-ranging wild birds (n=297) identified three species that harboured or excreted APMV1 and ACoVs...
May 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28529504/a-novel-avian-paramyxovirus-putative-serotype-15-isolated-from-wild-birds
#15
Hyun-Jeong Lee, Ji-Ye Kim, Youn-Jeong Lee, Eun-Kyung Lee, Byoung-Min Song, Hee-Soo Lee, Kang-Seuk Choi
In January 2014, a viral hemagglutinating agent named UPO216 was isolated from fecal droppings of wild birds at the UPO wetland in South Korea during an avian influenza surveillance program. Electron microscopy identified the UPO216 virus as an avian paramyxovirus (APMV). Pathogenicity tests and molecular pathotyping revealed that the virus was avirulent in chickens. The UPO216 virus was assigned to a serological group antigenically distinct from known serotypes of APMV (-1, -2, -3, -4, -6, -7, -8, and -9) by hemagglutination inhibition test, despite showing weak cross-reactivity with APMV-1 and APMV-9...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28522703/complete-genome-sequence-of-an-avian-paramyxovirus-type-4-strain-isolated-from-domestic-duck-at-a-live-bird-market-in-south-korea
#16
Erdene-Ochir Tseren-Ochir, Seong-Su Yuk, Jung-Hoon Kwon, Jin-Yong Noh, Woo-Tack Hong, Jei-Hyun Jeong, Sol Jeong, Yu-Jin Kim, Kyu-Jik Kim, Ji-Ho Lee, Jun-Beom Kim, Joong-Bok Lee, Seung-Yong Park, In-Soo Choi, Sang-Won Lee, Chang-Seon Song
We report here the first full-genome sequence of an avian paramyxovirus type 4 (APMV-4) strain isolated from a domestic mallard duck at a live bird market in South Korea. Phylogenetic analyses provide genetic information on a new genetic clade, APMV-4, isolated from a domestic duck and evidence of APMV-4 exchange between poultry and wild birds.
May 18, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28512347/insight-into-the-global-evolution-of-rodentia-associated-morbilli-related-paramyxoviruses
#17
Wissem Ghawar, Hervé Pascalis, Jihéne Bettaieb, Julien Mélade, Adel Gharbi, Mohamed Ali Snoussi, Dhafer Laouini, Steven M Goodman, Afif Ben Salah, Koussay Dellagi
One portion of the family Paramyxoviridae is a group of Unclassified Morbilli-Related Viruses (UMRV) recently recognized in wild small mammals. At a global level, the evolutionary history of these viruses is not properly understood and the relationships between UMRV and their hosts still remain largely unstudied. The present study revealed, for the first time, that Rodentia associated UMRV emerged from a common ancestor in southern Africa more than 4000 years ago. Sequenced UMRV originating from different regions in the world, clustered into four well-supported viral lineages, which suggest that strain diversification occurred during host dispersal and associated exchanges, with purifying selection pressure as the principal evolutionary force...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28508218/recovery-of-a-paramyxovirus-the-human-metapneumovirus-from-cloned-cdna
#18
B G van den Hoogen, R A M Fouchier
Human metapneumovirus (HMPV), a single-stranded negative-sense RNA virus belonging to the family Paramyxoviridae, is associated with respiratory tract illness, primarily in young children and persons with underlying disease. Based on genetic and antigenic variation, HMPV strains are classified into two serotypes, with isolates NL/1/00 and NL/1/99 as prototypes for serotypes A and B, respectively. The development of plasmid-based reverse genetics systems for both serotypes has resulted in developments of a wide range of vaccine candidates against HMPV infection...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28508216/rescue-of-sendai-virus-from-cloned-cdna
#19
Shringkhala Bajimaya, Tsuyoshi Hayashi, Toru Takimoto
Sendai virus (SeV) is a non-segment negative-sense RNA virus that naturally infects and causes pneumonia in mice. As a prototypic member of the family Paramyxoviridae, SeV has been characterized well, and these studies revealed numerous traits of paramyxovirus biology. The reverse genetics system to rescue SeV was first established in 1995. The virus was rescued from a cloned cDNA that contains full genome sequence flanked by T7 promoter and hepatitis delta virus ribozyme. To rescue SeV, it is necessary to infect cells with a recombinant vaccinia virus vTF7...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28486490/novel-avian-paramyxovirus-apmv-15-isolated-from-a-migratory-bird-in-south-america
#20
Luciano Matsumiya Thomazelli, Jansen de Araújo, Thomas Fabrizio, David Walker, Dilmara Reischak, Tatiana Ometto, Carla Meneguin Barbosa, Maria Virginia Petry, Richard J Webby, Edison Luiz Durigon
A novel avian paramyxovirus (APMV) isolated from a migratory bird cloacal swab obtained during active surveillance in April 2012 in the Lagoa do Peixe National Park, Rio Grande do Sul state, South of Brazil was biologically and genetically characterized. The nucleotide sequence of the full viral genome was completed using a next-generation sequencing approach. The genome was 14,952 nucleotides (nt) long, with six genes (3'-NP-P-M-F-HN-L-5') encoding 7 different proteins, typical of APMV. The fusion (F) protein gene of isolate RS-1177 contained 1,707 nucleotides in a single open reading frame encoding a protein of 569 amino acids...
2017: PloS One
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