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https://www.readbyqxmd.com/read/29780847/community-acquired-respiratory-paramyxovirus-infection-after-allogeneic-hematopoietic-cell-transplantation-a-single-center-experience
#1
Yasmin Spahr, Sarah Tschudin-Sutter, Veronika Baettig, Francesca Compagno, Michael Tamm, Jörg Halter, Sabine Gerull, Jakob Passweg, Hans H Hirsch, Nina Khanna
Background: Paramyxoviruses include respiratory syncytial virus (RSV), parainfluenza virus (PIV), and human metapneumovirus (MPV), which may cause significant respiratory tract infectious disease (RTID) and mortality after allogeneic hematopoietic cell transplantation (HCT). However, clinical data regarding frequency and outcome are scarce. Methods: We identified all paramyxovirus RTIDs in allogeneic HCT recipients diagnosed by multiplex polymerase chain reaction between 2010 and 2014...
May 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29769705/possible-role-of-the-nipah-virus-v-protein-in-the-regulation-of-the-interferon-beta-induction-by-interacting-with-ubx-domain-containing-protein1
#2
Shotaro Uchida, Ryo Horie, Hiroki Sato, Chieko Kai, Misako Yoneda
Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes lethal encephalitis in humans. We previously reported that the V protein, one of the three accessory proteins encoded by the P gene, is one of the key determinants of the pathogenesis of NiV in a hamster infection model. Satterfield B.A. et al. have also revealed that V protein is required for the pathogenicity of henipavirus in a ferret infection model. However, the complete functions of NiV V have not been clarified. In this study, we identified UBX domain-containing protein 1 (UBXN1), a negative regulator of RIG-I-like receptor signaling, as a host protein that interacts with NiV V...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29765101/favipiravir-t-705-protects-against-nipah-virus-infection-in-the-hamster-model
#3
Brian E Dawes, Birte Kalveram, Tetsuro Ikegami, Terry Juelich, Jennifer K Smith, Lihong Zhang, Arnold Park, Benhur Lee, Takashi Komeno, Yousuke Furuta, Alexander N Freiberg
Nipah and Hendra viruses are recently emerged bat-borne paramyxoviruses (genus Henipavirus) causing severe encephalitis and respiratory disease in humans with fatality rates ranging from 40-75%. Despite the severe pathogenicity of these viruses and their pandemic potential, no therapeutics or vaccines are currently approved for use in humans. Favipiravir (T-705) is a purine analogue antiviral approved for use in Japan against emerging influenza strains; and several phase 2 and 3 clinical trials are ongoing in the United States and Europe...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29758054/effect-of-fusion-protein-cleavage-site-sequence-on-generation-of-a-genotype-vii-newcastle-disease-virus-vaccine
#4
Vinoth K Manoharan, Berin P Varghese, Anandan Paldurai, Siba K Samal
Newcastle disease (ND) causes severe economic loss to poultry industry worldwide. Frequent outbreaks of ND in commercial chickens vaccinated with live vaccines suggest a need to develop improved vaccines that are genetically matched against circulating Newcastle disease virus (NDV) strains. In this study, the fusion protein cleavage site (FPCS) sequence of NDV strain Banjarmasin/010 (Banj), a genotype VII NDV, was individually modified using primer mutagenesis to those of avian paramyxovirus (APMV) serotypes 2, 7 and 8 and compared with the recombinant Banjarmasin (rBanj) with avirulent NDV LaSota cleavage site (rBanj-LaSota)...
2018: PloS One
https://www.readbyqxmd.com/read/29743368/stat2-dependent-immune-responses-ensure-host-survival-despite-the-presence-of-a-potent-viral-antagonist
#5
Vu Thuy Khanh Le-Trilling, Kerstin Wohlgemuth, Meike U Rückborn, Andreja Jagnjic, Fabienne Maaßen, Lejla Timmer, Benjamin Katschinski, Mirko Trilling
Pathogen encounter induces interferons which signal via Janus kinases and STAT transcription factors to establish an antiviral state. However, host and pathogens are situated in a continuous arms race which shapes host evolution towards optimized immune responses and the pathogens towards enhanced immune evasive properties.Mouse cytomegalovirus (MCMV) counteracts interferon responses by pM27-mediated degradation of STAT2 which directly affects the signaling of type I as well as type III interferons. Using MCMV mutants lacking M27 and mice lacking STAT2, we studied the opposing relationship between antiviral activities and viral antagonism in a natural host-pathogen pair in vitro and in vivo In contrast to wt-MCMV, ΔM27-MCMV was efficiently cleared from all organs within a few days in BALB/c, C57BL/6, and 129 mice, highlighting the general importance of STAT2 antagonism for MCMV replication...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29716604/the-impact-of-aloe-vera-and-licorice-extracts-on-selected-mechanisms-of-humoral-and-cell-mediated-immunity-in-pigeons-experimentally-infected-with-ppmv-1
#6
Daria Dziewulska, Tomasz Stenzel, Marcin Śmiałek, Bartłomiej Tykałowski, Andrzej Koncicki
BACKGROUND: The aim of the study was to evaluate the impact of herbal extracts on selected immunity mechanisms in clinically healthy pigeons and pigeons inoculated with the pigeon paramyxovirus type 1 (PPMV-1). For the first 7 days post-inoculation (dpi), an aqueous solution of Aloe vera or licorice extract was administered daily at 300 or 500 mg/kg body weight (BW). The birds were euthanized at 4, 7 and 14 dpi, and spleen samples were collected during necropsy. Mononuclear cells were isolated from spleen samples and divided into two parts: one part was used to determine the percentage of IgM+ B cells in a flow cytometric analysis, and the other was used to evaluate the expression of genes encoding IFN-γ and surface receptors on CD3+ , CD4+ and CD8+ T cells...
May 2, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29712906/promotion-of-virus-assembly-and-organization-by-the-measles-virus-matrix-protein
#7
Zunlong Ke, Joshua D Strauss, Cheri M Hampton, Melinda A Brindley, Rebecca S Dillard, Fredrick Leon, Kristen M Lamb, Richard K Plemper, Elizabeth R Wright
Measles virus (MeV) remains a major human pathogen, but there are presently no licensed antivirals to treat MeV or other paramyxoviruses. Here, we use cryo-electron tomography (cryo-ET) to elucidate the principles governing paramyxovirus assembly in MeV-infected human cells. The three-dimensional (3D) arrangement of the MeV structural proteins including the surface glycoproteins (F and H), matrix protein (M), and the ribonucleoprotein complex (RNP) are characterized at stages of virus assembly and budding, and in released virus particles...
April 30, 2018: Nature Communications
https://www.readbyqxmd.com/read/29695428/electrostatic-interactions-between-hendra-virus-matrix-proteins-are-required-for-efficient-virus-like-particle-assembly
#8
Yu Chih Liu, Julian Grusovin, Timothy E Adams
Hendra virus (HeV) is a zoonotic paramyxovirus belonging to the genus Henipavirus. HeV is highly pathogenic, and it can cause severe neurological and respiratory illnesses in both humans and animals, with an extremely high mortality rate of up to 70%. Amongst the genes that HeV encodes, the matrix (M) protein forms an integral part of the virion structure and plays critical roles in coordinating viral assembly and budding. Nevertheless, the molecular mechanism of this process is not fully elucidated. Here, we determined the crystal structure of HeV M to 2...
April 25, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29669880/transmembrane-domains-of-highly-pathogenic-viral-fusion-proteins-exhibit-trimeric-association-in-vitro
#9
Stacy R Webb, Stacy E Smith, Michael G Fried, Rebecca Ellis Dutch
Enveloped viruses require viral fusion proteins to promote fusion of the viral envelope with a target cell membrane. To drive fusion, these proteins undergo large conformational changes that must occur at the right place and at the right time. Understanding the elements which control the stability of the prefusion state and the initiation of conformational changes is key to understanding the function of these important proteins. The construction of mutations in the fusion protein transmembrane domains (TMDs) or the replacement of these domains with lipid anchors has implicated the TMD in the fusion process...
April 25, 2018: MSphere
https://www.readbyqxmd.com/read/29643201/nipah-virus-infection
#10
Brenda S P Ang, Tchoyoson C C Lim, Linfa Wang
Nipah virus, a Paramyxovirus related to Hendra first emerged in Malaysia in 1998. Clinical presentation ranges from asymptomatic infection to fatal encephalitis. Malaysia has had no more cases since 1999, but outbreaks continue to occur in Bangladesh and India. In the Malaysia-Singapore outbreak, transmission occurred primarily through contact with pigs while in Bangladesh-India, it is associated with ingestion of contaminated date palm sap and human-to-human transmission. Bats are the main reservoir for this virus which can cause disease in humans and animals...
April 11, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29601894/susceptibility-of-paramyxoviruses-and-filoviruses-to-inhibition-by-2-monofluoro-and-2-difluoro-4-azidocytidine-analogs
#11
Michael K Lo, Paul C Jordan, Sarah Stevens, Yuen Tam, Jerome Deval, Stuart T Nichol, Christina F Spiropoulou
Ebolaviruses, marburgviruses, and henipaviruses are zoonotic pathogens belonging to the Filoviridae and Paramyxoviridae families. They exemplify viruses that continue to spill over into the human population, causing outbreaks characterized by high mortality and significant clinical sequelae in survivors of infection. There are currently no approved small molecule therapeutics for use in humans against these viruses. In this study, we evaluated the antiviral activity of the nucleoside analog 4'-azidocytidine (4'N3 -C, R1479) and its 2'-monofluoro- and 2'-difluoro-modified analogs (2'F-4'N3 -C and 2'diF-4'N3 -C) against representative paramyxoviruses (Nipah virus, Hendra virus, measles virus, and human parainfluenza virus 3) and filoviruses (Ebola virus, Sudan virus, and Ravn virus)...
March 27, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29601871/molecular-characterization-and-genetic-diversity-of-avian-paramyxovirus-type-4-isolated-in-south-korea-from-2013-to-2017
#12
Erdene-Ochir Tseren-Ochir, Jung-Hoon Kwon, Jin-Yong Noh, Jei-Hyun Jeong, Sol Jeong, Kyu-Jik Kim, Ji-Ho Lee, Jun-Beom Kim, Yu-Jin Kim, Sun-Hak Lee, Jun-Young Kim, Chang-Seon Song
In recent years, avian paramyxovirus type 4 (APMV-4) frequently isolated from wild and domestic bird populations particularly waterfowls worldwide. However, molecular characteristics and genetic diversity of APMV-4 are uncertain, owing to the limited availability of sequence information. A total of 11 APMV-4 strains from 9850 fecal, swab, and environmental samples were isolated during the surveillance program in wintering seasons of 2013-2017 in South Korea. We performed genetic characterization and phylogenetic analysis to investigate the genetic diversity and relatedness between isolates from the region...
March 27, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29601508/deep-sequencing-based-transcriptome-profiling-reveals-avian-interferon-stimulated-genes-and-provides-comprehensive-insight-into-newcastle-disease-virus-induced-host-responses
#13
Weiwei Liu, Xusheng Qiu, Cuiping Song, Yingjie Sun, Chunchun Meng, Ying Liao, Lei Tan, Zhuang Ding, Xiufan Liu, Chan Ding
Newcastle disease virus (NDV) is an avian paramyxovirus that causes significant economic losses to the poultry industry worldwide, with variations in NDV pathogenicity due to the differences in virulence between strains. However, there is limited knowledge regarding the avian innate immune response to NDV infection. In this study, transcriptional profiles were obtained from chick embryo fibroblasts (CEFs) that were infected with the highly virulent NDV Herts/33 strain or the nonvirulent LaSota strain using RNA-seq...
March 30, 2018: Viruses
https://www.readbyqxmd.com/read/29595381/phylogenetic-analysis-of-pigeon-paramyxoviruses-type-1-identified-in-mourning-collared-doves-streptopelia-decipiens-in-namibia-africa
#14
Umberto Molini, Gottlieb Aikukutu, Siegfried Khaiseb, Giovanni Cattoli, William G Dundon
We generated the complete sequence of the fusion ( F) protein gene from six pigeon paramyxoviruses type 1 (PPMV-1) isolated from mourning collared doves ( Streptopelia decipiens) in Namibia, Africa between 2016 and 2017. All of the isolates had an F gene cleavage site motif of112 RRQKRF117 characteristic of virulent viruses. A phylogenetic analysis using the full F gene sequence revealed that the viruses belonged to genotype VIa and were epidemiologically related to PPMV-1s from Asia, Europe, and North America...
March 29, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29579772/community-acquired-respiratory-viruses
#15
Jens Gottlieb
The incidence of community-acquired respiratory viruses (CARVs) is ∼15 cases per 100 patient-years after lung transplantation (LTx). Paramyxoviruses account for almost 50% of the cases of CARV infection in LTx. Most patients will be symptomatic with a mean decline of 15 to 20% in forced expiratory volume in 1 second. The attributable death rate is low in recent years 15 to 25% CARV infected LTx patients will develop chronic lung allograft dysfunction within a year after CARV infection. This risk seems to be increased in comparison to the noninfected LTx recipient...
April 2018: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29572949/detection-and-seroprevalence-of-morbillivirus-and-other-paramyxoviruses-in-geriatric-cats-with-and-without-evidence-of-azotemic-chronic-kidney-disease
#16
Katie Elizabeth McCallum, Sam Stubbs, Nicholas Hope, Ian Mickleburgh, Dave Dight, Laurence Tiley, Tim L Williams
BACKGROUND: Feline morbillivirus (FeMV) is associated with the presence of tubulo-interstitial nephritis (TIN) in cats, however the seroprevalence of FeMV in the UK and the association between the presence of FeMV and renal azotemia is unknown HYPOTHESIS/OBJECTIVES: To identify whether paramyxoviruses are present in urine samples of geriatric cats and to develop an assay to assess FeMV seroprevalence. To investigate the relationship between both urinary paramyxovirus (including FeMV) excretion and FeMV seroprevalence and azotemic chronic kidney disease (CKD)...
March 23, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29570719/avian-viral-surveillance-in-victoria-australia-and-detection-of-two-novel-avian-herpesviruses
#17
Jemima Amery-Gale, Carol A Hartley, Paola K Vaz, Marc S Marenda, Jane Owens, Paul A Eden, Joanne M Devlin
Viruses in avian hosts can pose threats to avian health and some have zoonotic potential. Hospitals that provide veterinary care for avian patients may serve as a site of exposure of other birds and human staff in the facility to these viruses. They can also provide a useful location to collect samples from avian patients in order to examine the viruses present in wild birds. This study aimed to investigate viruses of biosecurity and/or zoonotic significance in Australian birds by screening samples collected from 409 birds presented to the Australian Wildlife Health Centre at Zoos Victoria's Healesville Sanctuary for veterinary care between December 2014 and December 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29566184/fusion-inhibitory-lipopeptides-engineered-for-prophylaxis-of-nipah-virus-in-primates
#18
Cyrille Mathieu, Matteo Porotto, Tiago Figueira, Branka Horvat, Anne Moscona
Background: The emerging zoonotic paramyxovirus Nipah virus (NiV) causes severe respiratory and neurological disease in humans, with high fatality rates. NiV can be transmitted via person-to-person contact, posing a high risk for epidemic outbreaks. However, a broadly applicable approach for human NiV outbreaks in field settings is lacking. Methods: We engineered new antiviral lipopeptides and analyzed in vitro fusion inhibition to identify an optimal candidate for prophylaxis of NiV infection in the lower respiratory tract, and assessed antiviral efficiency in two different animal models...
March 16, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29556820/genetic-diversity-of-avian-avulavirus-1-newcastle-disease-virus-genotypes-vig-and-viib-circulating-in-wild-birds-in-kazakhstan
#19
Mukhit B Orynbayev, Sasan Fereidouni, Abylay R Sansyzbai, Bakhytkul A Seidakhmetova, Vitaliy M Strochkov, Askar M Nametov, Sandugash O Sadikaliyeva, Asel Nurgazieva, Kaissar K Tabynov, Nurkuysa M Rametov, Kulyaisan T Sultankulova
In order to improve current understanding of the molecular epidemiology of avian avulavirus 1 (AAvV-1, formerly avian paramyxovirus 1) in wild birds in Kazakhstan, 860 cloacal swab samples were evaluated. Samples were collected from 37 families of wild birds in nine different regions in the years 2011 and 2014. Overall, 54 positive samples (4.2%) were detected from 17 different families of wild birds, and 16 AAvV-1 isolates were characterized. Three of the isolates contained the fusion protein cleavage site motif RRQKR, and 13 contained KRQKR, which is typical for pathogenic strains of AAvV-1...
March 20, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29532715/importin-%C3%AE-5-negatively-regulates-importin-%C3%AE-1-mediated-nuclear-import-of-newcastle-disease-virus-matrix-protein-and-viral-replication-and-pathogenicity-in-chicken-fibroblasts
#20
Zhiqiang Duan, Haixu Xu, Xinqin Ji, Jiafu Zhao, Houqiang Xu, Yan Hu, Shanshan Deng, Shunlin Hu, Xiufan Liu
The matrix (M) protein of Newcastle disease virus (NDV) is demonstrated to localize in the nucleus via intrinsic nuclear localization signal (NLS), but cellular proteins involved in the nuclear import of NDV M protein and the role of M's nuclear localization in the replication and pathogenicity of NDV remain unclear. In this study, importin β1 was screened to interact with NDV M protein by yeast two-hybrid screening. This interaction was subsequently confirmed by co-immunoprecipitation and pull-down assays...
December 31, 2018: Virulence
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