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Newcastle disease virus, oncolytics

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https://www.readbyqxmd.com/read/28687873/%C3%AE-2-6-linked-sialic-acid-serves-as-a-high-affinity-receptor-for-cancer-oncolytic-virotherapy-with-newcastle-disease-virus
#1
Qian Li, Ding Wei, Fei Feng, Xi-Long Wang, Can Li, Zhi-Nan Chen, Huijie Bian
PURPOSE: Newcastle disease virus (NDV) has been applied to oncolytic virotherapy for decades due to its naturally oncolytic property. In spite of the substantiation of the sialic acid receptors of NDV on host cells, knowledge of preference of sialic acid linkage in viral attachment and oncolytic effect is lacking and imperative to be elucidated. METHODS: Surface plasmon resonance analysis and competitive inhibition with sialylated glycan receptor analogues were used to determine the affinity and the preference of sialic acid receptor...
July 7, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28592535/newcastle-disease-virus-establishes-persistent-infection-in-tumor-cells-in-vitro-contribution-of-the-cleavage-site-of-fusion-protein-and-second-sialic-acid-binding-site-of-hemagglutinin-neuraminidase
#2
Udaya S Rangaswamy, Weijia Wang, Xing Cheng, Patrick McTamney, Danielle Carroll, Hong Jin
Newcastle disease virus (NDV) is an oncolytic virus being developed for the treatment of cancer. Following infection of a human ovarian cancer cell line (OVCAR3) with a recombinant low-pathogenic NDV, persistent infection was established in a subset of tumor cells. Persistently infected (PI) cells exhibited resistance to superinfection with NDV and established an antiviral state, as demonstrated by upregulation of interferon and interferon-induced genes such as myxoma resistance gene 1 (Mx1) and retinoic acid-inducing gene-I (RIG-I)...
August 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28591723/rip1-is-a-central-signaling-protein-in-regulation-of-tnf-%C3%AE-trail-mediated-apoptosis-and-necroptosis-during-newcastle-disease-virus-infection
#3
Ying Liao, Hua-Xia Wang, Xiang Mao, Hongjie Fang, Huang Wang, Yanrong Li, Yingjie Sun, Chun Meng, Lei Tan, Cuiping Song, Xusheng Qiu, Chan Ding
Newcastle disease virus (NDV) is an oncolytic virus which selectively replicates in tumor cells and exerts anti-tumor cytotoxic activity by promoting cell death. In this study, we focus on characterization of the underlying mechanisms of NDV-induced cell death in HeLa cells. We find that NDV Herts/33 strain triggers both extrinsic and intrinsic apoptosis at late infection times. The activation of NF-кB pathway and subsequent up-regulation of TNF-α/TRAIL initiates extrinsic apoptosis, leading to activation of caspase 8 and cleavage of Bid into tBid...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28578522/evaluation-of-the-oncolytic-potential-of-r2b-mukteshwar-vaccine-strain-of-newcastle-disease-virus-ndv-in-a-colon-cancer-cell-line-sw-620
#4
Kishan K Sharma, Irsadullakhan H Kalyani, Jogeswar Mohapatra, Satish D Patel, Dharmesh R Patel, Priti D Vihol, Abhijit Chatterjee, Dinesh R Patel, Bhavesh Vyas
Virotherapy is emerging as an alternative treatment of cancer. Among the candidate oncolytic viruses (OVs), Newcastle disease virus (NDV) has emerged as a promising non-engineered OV. In the present communication, we explored the oncolytic potential of R2B Mukteshwar strain of NDV using SW-620 colon cancer cells. SW-620 cells were xenografted in nude mice and after evaluation of the safety profile, 1 x 10(7) plaque forming units (PFU) of NDV were inoculated as virotherapeutic agent via the intratumoral (I/T) and intravenous (I/V) route...
June 3, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28536382/fifty-years-of-clinical-application-of-newcastle-disease-virus-time-to-celebrate
#5
REVIEW
Volker Schirrmacher
This review provides an overview of 50 years of basic and clinical research on an oncolytic avian virus, Newcastle Disease Virus (NDV), which has particular anti-neoplastic and immune stimulatory properties. Of special interest is the fact that this biological agent induces immunogenic cell death and systemic anti-tumor immunity. Furthermore, localized oncolytic virotherapy with NDV was shown to overcome systemic tumor resistance to immune checkpoint blockade immunotherapy. Clinical experience attests to low side effects and a high safety profile...
July 20, 2016: Biomedicines
https://www.readbyqxmd.com/read/28388537/ndv-d90-suppresses-growth-of-gastric-cancer-and-cancer-related-vascularization
#6
Hong Sui, Kaibing Wang, Rui Xie, Xi Li, Kunpeng Li, Yuxian Bai, Xishan Wang, Bin Bai, Dan Chen, Jiazhuang Li, Baozhong Shen
Recent reports suggest promises on using oncolytic Newcastle disease viruses (NDV) to treat different cancers, while the effects of a NDV-D90 strain on gastric cancer remain unknown. Here we showed that NDV-D90 induced gastric cancer cell apoptosis in a dose-dependent manner in 3 gastric cancer cell lines BGC-823, SGC-7901 and MKN-28. Pronounced reduction in cell invasion was detected in NDV-D90-treated BGC-823 and SGC-7901 cells, but not in MKN-28 cells. The increases in cell apoptosis and reduction in cell growth in NDV-D90-treated gastric cancer cells seemingly resulted from augmentation of p38 signaling and suppression of ERK1/2 and Akt signaling...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28326624/current-status-of-clinical-trials-assessing-oncolytic-virus-therapy-for-urological-cancers
#7
REVIEW
Satoru Taguchi, Hiroshi Fukuhara, Yukio Homma, Tomoki Todo
Oncolytic virus therapy has recently been recognized as a promising new option for cancer treatment. Oncolytic viruses replicate selectively in cancer cells, thus killing them without harming normal cells. Notably, T-VEC (talimogene laherparepvec, formerly called OncoVEX(GM)(-)(CSF) ), an oncolytic herpes simplex virus type 1, was approved by the US Food and Drug Administration for the treatment of inoperable melanoma in October 2015, and was subsequently approved in Europe and Australia in 2016. The efficacies of many types of oncolytic viruses against urological cancers have been investigated in preclinical studies during the past decade, and some have already been tested in clinical trials...
March 21, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28246027/recombinant-newcastle-disease-virus-expressing-human-trail-as-a-potential-candidate-for-hepatoma-therapy
#8
Yunzhou Wu, Jinjiao He, Jingshu Geng, Ying An, Xianlong Ye, Shijun Yan, Qingzhong Yu, Jiechao Yin, Zhenyu Zhang, Deshan Li
Newcastle disease virus (NDV) have shown oncolytic therapeutic efficacy in preclinical studies and are currently proved for clinical trials. We have previously reported, for the first time, NDV Anhinga strain has an efficient cancer therapeutic efficacy in hepatoma. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) functions as a cytokine to selectively kill various cancer cells without toxicity to most normal cells. Numerous studies have demonstrated the potential use of recombinant soluble TRAIL as a cancer therapeutic agent...
May 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28194010/intratumoral-modulation-of-the-inducible-co-stimulator-icos-by-recombinant-oncolytic-virus-promotes-systemic-anti-tumour-immunity
#9
Dmitriy Zamarin, Rikke B Holmgaard, Jacob Ricca, Tamar Plitt, Peter Palese, Padmanee Sharma, Taha Merghoub, Jedd D Wolchok, James P Allison
Emerging data suggest that locoregional cancer therapeutic approaches with oncolytic viruses can lead to systemic anti-tumour immunity, although the appropriate targets for intratumoral immunomodulation using this strategy are not known. Here we find that intratumoral therapy with Newcastle disease virus (NDV), in addition to the activation of innate immunity, upregulates the expression of T-cell co-stimulatory receptors, with the inducible co-stimulator (ICOS) being most notable. To explore ICOS as a direct target in the tumour, we engineered a recombinant NDV-expressing ICOS ligand (NDV-ICOSL)...
February 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/27902314/newcastle-disease-virus-degrades-hif-1%C3%AE-through-proteasomal-pathways-independent-of-vhl-and-p53
#10
Noraini Abd-Aziz, Eric J Stanbridge, Norazizah Shafee
Newcastle disease virus (NDV) is a candidate agent for oncolytic virotherapy. Despite its potential, the exact mechanism of its oncolysis is still not known. Recently, we reported that NDV exhibited an increased oncolytic activity in hypoxic cancer cells. These types of cells negatively affect therapeutic outcome by overexpressing pro-survival genes under the control of the hypoxia-inducible factor (HIF). HIF-1 is a heterodimeric transcriptional factor consisting of a regulated α (HIF-1α) and a constitutive β subunit (HIF-1β)...
December 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27861142/newcastle-disease-virus-employs-macropinocytosis-and-rab5a-dependent-intracellular-trafficking-to-infect-df-1-cells
#11
Lei Tan, Yuqiang Zhang, Yuan Zhan, Yanmei Yuan, Yingjie Sun, Xusheng Qiu, Chunchun Meng, Cuiping Song, Ying Liao, Chan Ding
Oncolytic Newcastle disease virus (NDV) reportedly employs direct fusion of the viral envelope with the plasma membrane and caveolae-dependent endocytosis to enter cells. Here, we show that macropinocytosis and clathrin-mediated endocytosis are involved in NDV entry into a galline embryonic fibroblast cell line. Upon specific inhibition of clathrin assembly, GTPase dynamin, Na+/H+ exchangers, Ras-related C3 botulinum toxin substrate 1, p21 activated kinase 1 or protein kinase C, entry of NDV and its propagation were suppressed...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27825920/a-generic-viral-dynamic-model-to-systematically-characterize-the-interaction-between-oncolytic-virus-kinetics-and-tumor-growth
#12
Melanie I Titze, Julia Frank, Michael Ehrhardt, Sigrun Smola, Norbert Graf, Thorsten Lehr
Oncolytic viruses (OV) represent an encouraging new therapeutic concept for treatment of human cancers. OVs specifically replicate in tumor cells and initiate cell lysis whilst tumor cells act as endogenous bioreactors for virus amplification. This complex bidirectional interaction between tumor and oncolytic virus hampers the establishment of a straight dose-concentration-effect relation. We aimed to develop a generic mathematical pharmacokinetic/pharmacodynamics (PK/PD) model to characterize the relationship between tumor cell growth and kinetics of different OVs...
January 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27736965/identification-of-optimal-insertion-site-in-recombinant-newcastle-disease-virus-rndv-vector-expressing-foreign-gene-to-enhance-its-anti-tumor-effect
#13
Ziye Pan, Jinjiao He, Lubna M Rasoul, Yunye Liu, Ruixiang Che, Yun Ding, Xiaocheng Guo, Jiarui Yang, Dehua Zou, Hua Zhang, Deshan Li, Hongwei Cao
Recombinant Newcastle disease virus (rNDV) is tumor selective and intrinsically oncolytic, which has been developed as a vector to express exogenous genes to enhance its oncolytic efficacy. Our previous studies found that insertion sites of foreign gene in rNDV vector affected its expression and anti-tumor activities. However, the optimal insertion site for foreign genes remains unknown. In this study, we inserted the enhanced green fluorescence protein (EGFP) and IL2 genes into four different intergenic regions of the rNDV using reverse genetics technology...
2016: PloS One
https://www.readbyqxmd.com/read/27724977/mesenchymal-stem-cells-enhance-the-oncolytic-effect-of-newcastle-disease-virus-in-glioma-cells-and-glioma-stem-cells-via-the-secretion-of-trail
#14
Gila Kazimirsky, Wei Jiang, Shimon Slavin, Amotz Ziv-Av, Chaya Brodie
BACKGROUND: Newcastle disease virus (NDV) is an avian paramyxovirus, which selectively exerts oncolytic effects in cancer cells. Mesenchymal stem cells (MSCs) have been reported to affect tumor growth and deliver anti-tumor agents to experimental glioblastoma (GBM). Here, we explored the effects of NDV-infected MSCs derived from different sources, on glioma cells and glioma stem cells (GSCs) and the mechanisms involved in their effects. METHODS: The glioma cell lines (A172 and U87) and primary GSCs that were generated from GBM tumors were used in this study...
October 10, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27357231/the-lxr-ligand-gw3965-inhibits-newcastle-disease-virus-infection-by-affecting-cholesterol-homeostasis
#15
Xiang-Xiang Sheng, Ying-Jie Sun, Yuan Zhan, Yu-Rong Qu, Hua-Xia Wang, Miao Luo, Ying Liao, Xu-Sheng Qiu, Chan Ding, Hong-Jie Fan, Xiang Mao
Newcastle disease (ND) is a contagious disease that affects most species of birds. Its causative pathogen, Newcastle disease virus (NDV), also exhibits considerable oncolytic activity against mammalian cancers. A better understanding of the pathogenesis of NDV will help us design efficient vaccines and novel anticancer strategies. GW3965, a widely used synthetic ligand of liver X receptor (LXR), induces the expression of LXRs and its downstream genes, including ATP-binding cassette transporter A1 (ABCA1). ABCA1 regulates cellular cholesterol homeostasis...
September 2016: Archives of Virology
https://www.readbyqxmd.com/read/27269659/newcastle-disease-virus-infection-induces-activation-of-the-nlrp3-inflammasome
#16
Binbin Wang, Jie Zhu, Dandan Li, Yang Wang, Yuan Zhan, Lei Tan, Xusheng Qiu, Yingjie Sun, Cuiping Song, Chunchun Meng, Liao Ying, Mao Xiang, Guangxun Meng, Chan Ding
Inflammatory responses are important aspects of the innate immune system during virus infection. We found that Newcastle disease virus can induce inflammasome activation in the human macrophage-like cell line THP-1. Viral replication was required for inflammasome activation, and small hairpin RNA knockdown experiments indicated that IL-1β secretion was mediated by the NLRP3 inflammasome. We also verified the results in LPS-primed bone marrow-derived macrophages (BMDMs) from NLRP3-deficient and wild type mice...
September 2016: Virology
https://www.readbyqxmd.com/read/27174862/recombinant-newcastle-disease-virus-ndv-anh-il-2-expressing-human-il-2-as-a-potential-candidate-for-suppresses-growth-of-hepatoma-therapy
#17
Yunzhou Wu, Jinjiao He, Ying An, Xi Wang, Yunye Liu, Shijun Yan, Xianlong Ye, Jianying Qi, Shenglong Zhu, Qingzhong Yu, Jiechao Yin, Deshan Li, Wenfei Wang
Newcastle disease virus (NDV) have shown oncolytic therapeutic efficacy in preclinical study and are currently approved for clinical trials. NDV Anhinga strain which is a mesogenic strain should be classified as lytic strain and has a therapeutic efficacy in hepatocellular cancer. In this study, we evaluated the capacity of NDV Anhinga strain to elicit immune reaction in vivo and the possibility for using as a vaccine vector for expressing tumor therapeutic factors. Interleukin-2 (IL-2) could boost the immune response against the tumor cells...
September 2016: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/27153814/cd55-is-a-key-complement-regulatory-protein-that-counteracts-complement-mediated-inactivation-of-newcastle-disease-virus
#18
Udaya S Rangaswamy, Christopher R Cotter, Xing Cheng, Hong Jin, Zhongying Chen
Newcastle disease virus (NDV) is being developed as an oncolytic virus for virotherapy. In this study we analysed the regulation of complement-mediated inactivation of a recombinant NDV in different host cells. NDV grown in human cells was less sensitive to complement-mediated virus inactivation than NDV grown in embryonated chicken eggs. Additionally, NDV produced from HeLa-S3 cells is more resistant to complement than NDV from 293F cells, which correlated with higher expression and incorporation of complement regulatory proteins (CD46, CD55 and CD59) into virions from HeLa-S3 cells...
August 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27009956/genetic-modification-of-oncolytic-newcastle-disease-virus-for-cancer-therapy
#19
Xing Cheng, Weijia Wang, Qi Xu, James Harper, Danielle Carroll, Mark S Galinski, JoAnn Suzich, Hong Jin
UNLABELLED: Clinical development of a mesogenic strain of Newcastle disease virus (NDV) as an oncolytic agent for cancer therapy has been hampered by its select agent status due to its pathogenicity in avian species. Using reverse genetics, we have generated a lead candidate oncolytic NDV based on the mesogenic NDV-73T strain that is no longer classified as a select agent for clinical development. This recombinant NDV has a modification at the fusion protein (F) cleavage site to reduce the efficiency of F protein cleavage and an insertion of a 198-nucleotide sequence into the HN-L intergenic region, resulting in reduced viral gene expression and replication in avian cells but not in mammalian cells...
June 1, 2016: Journal of Virology
https://www.readbyqxmd.com/read/26689432/oncolytic-newcastle-disease-virus-expressing-chimeric-antibody-enhanced-anti-tumor-efficacy-in-orthotopic-hepatoma-bearing-mice
#20
Ding Wei, Qian Li, Xi-Long Wang, Yuan Wang, Jing Xu, Fei Feng, Gang Nan, Bin Wang, Can Li, Ting Guo, Zhi-Nan Chen, Huijie Bian
BACKGROUND: Oncolytic virus which arms the therapeutic gene to enhance anti-tumor activity is a prevalent strategy to improve oncovirotherapy of cancer. Newcastle disease virus (NDV) is a naturally oncolytic virus used for cancer therapy. Previously, we generated a mouse-human chimeric HAb18 antibody (cHAb18) against tumor-associated antigen CD147 and demonstrated the inhibition of invasion and migration of hepatocellular carcinoma (HCC) cells. Here, we constructed a recombinant NDV carrying intact cHAb18 gene (rNDV-18HL) based on Italien strain using a reverse genetics system...
2015: Journal of Experimental & Clinical Cancer Research: CR
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