Yu Chen, Shanshan Zhu, Tianxing Liao, Chunxuan Wang, Jiajun Han, Zhenyu Yang, Xiaolong Lu, Zenglei Hu, Jiao Hu, Xiaoquan Wang, Min Gu, Ruyi Gao, Kaituo Liu, Xiaowen Liu, Chan Ding, Shunlin Hu, Xiufan Liu
Lysosomes are acidic organelles that mediate the degradation and recycling of cellular waste materials. Damage to lysosomes can cause lysosomal membrane permeabilization (LMP) and trigger different types of cell death, including apoptosis. Newcastle disease virus (NDV) can naturally infect most birds. Additionally, it serves as a promising oncolytic virus known for its effective infection of tumor cells and induction of intensive apoptotic responses. However, the involvement of lysosomes in NDV-induced apoptosis remains poorly understood...
February 2024: PLoS Pathogens