keyword
Keywords Newcastle disease virus, oncol...

Newcastle disease virus, oncolytics

https://read.qxmd.com/read/38543739/the-ndv-mls-as-an-immunotherapeutic-strategy-for-breast-cancer-proof-of-concept-in-female-companion-dogs-with-spontaneous-mammary-cancer
#1
JOURNAL ARTICLE
Diana Sánchez, Gabriela Cesarman-Maus, Laura Romero, Rogelio Sánchez-Verin, David Vail, Marina Guadarrama, Rosana Pelayo, Rosa Elena Sarmiento-Silva, Marcela Lizano
The absence of tumor-infiltrating lymphocytes negatively impacts the response to chemotherapy and prognosis in all subtypes of breast cancer. Therapies that stimulate a proinflammatory environment may help improve the response to standard treatments and also to immunotherapies such as checkpoint inhibitors. Newcastle disease virus (NDV) shows oncolytic activity, as well as immune modulating potential, in the treatment of breast cancer in vitro and in vivo; however, its potential to enhance tumor-infiltrating immune cells in breast cancer has yet to be evaluated...
February 28, 2024: Viruses
https://read.qxmd.com/read/38529281/corrigendum-cd44-targeted-delivery-of-oncolytic-newcastle-disease-virus-encapsulated-in-thiolated-chitosan-for-sustained-release-in-cervical-cancer-a-targeted-immunotherapy-approach
#2
Kousain Kousar, Faiza Naseer, Maisa Siddiq Abduh, Sadia Anjum, Tahir Ahmad
[This corrects the article DOI: 10.3389/fimmu.2023.1175535.].
2024: Frontiers in Immunology
https://read.qxmd.com/read/38413399/production-of-recombinant-vesicular-stomatitis-virus-based-vectors-by-tangential-flow-depth-filtration
#3
JOURNAL ARTICLE
Sven Göbel, Lars Pelz, Cristina A T Silva, Béla Brühlmann, Charles Hill, Jennifer Altomonte, Amine Kamen, Udo Reichl, Yvonne Genzel
Cell culture-based production of vector-based vaccines and virotherapeutics is of increasing interest. The vectors used not only retain their ability to infect cells but also induce robust immune responses. Using two recombinant vesicular stomatitis virus (rVSV)-based constructs, we performed a proof-of-concept study regarding an integrated closed single-use perfusion system that allows continuous virus harvesting and clarification. Using suspension BHK-21 cells and a fusogenic oncolytic hybrid of vesicular stomatitis virus and Newcastle disease virus (rVSV-NDV), a modified alternating tangential flow device (mATF) or tangential flow depth filtration (TFDF) systems were used for cell retention...
February 27, 2024: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/38411946/oncolytic-newcastle-disease-virus-induced-degradation-of-yap-through-e3-ubiquitin-ligase-prkn-to-exacerbate-ferroptosis-in-tumor-cells
#4
JOURNAL ARTICLE
Yifan Sun, Lanlan Tang, Xianjin Kan, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao, Venugopal Nair, Chan Ding, Xiufan Liu, Yingjie Sun
Ferroptosis, a form of programmed cell death characterized by iron-dependent lipid peroxidation, has recently gained considerable attention in the field of cancer therapy. There is significant crosstalk between ferroptosis and several classical signaling pathways, such as the Hippo pathway, which suppresses abnormal growth and is frequently aberrant in tumor tissues. Yes-associated protein 1 (YAP), the core effector molecule of the Hippo pathway, is abnormally expressed and activated in a variety of malignant tumor tissues...
February 27, 2024: Journal of Virology
https://read.qxmd.com/read/38397030/exploration-of-the-delivery-of-oncolytic-newcastle-disease-virus-by-gelatin-methacryloyl-microneedles
#5
JOURNAL ARTICLE
Qiang Zhang, Jintong Na, Xiyu Liu, Jian He
Oncolytic Newcastle disease virus is a new type of cancer immunotherapy drug. This paper proposes a scheme for delivering oncolytic viruses using hydrogel microneedles. Gelatin methacryloyl (GelMA) was synthesized by chemical grafting, and GelMA microneedles encapsulating oncolytic Newcastle disease virus (NDV) were prepared by micro-molding and photocrosslinking. The release and expression of NDV were tested by immunofluorescence and hemagglutination experiments. The experiments proved that GelMA was successfully synthesized and had hydrogel characteristics...
February 16, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38377149/the-np-protein-of-newcastle-disease-virus-dictates-its-oncolytic-activity-by-regulating-viral-mrna-translation-efficiency
#6
JOURNAL ARTICLE
Tianxing Liao, Yu Chen, Lili Guo, Shanshan Zhu, Tiansong Zhan, Xiaolong Lu, Haixu Xu, Zenglei Hu, Jiao Hu, Min Gu, Xiaowen Liu, Xiaoquan Wang, Shunlin Hu, Xiufan Liu
Newcastle disease virus (NDV) has been extensively studied as a promising oncolytic virus for killing tumor cells in vitro and in vivo in clinical trials. However, the viral components that regulate the oncolytic activity of NDV remain incompletely understood. In this study, we systematically compared the replication ability of different NDV genotypes in various tumor cells and identified NP protein determines the oncolytic activity of NDV. On the one hand, NDV strains with phenylalanine (F) at the 450th amino acid position of the NP protein (450th-F-NP) exhibit a loss of oncolytic activity...
February 20, 2024: PLoS Pathogens
https://read.qxmd.com/read/38354122/the-hn-protein-of-newcastle-disease-virus-induces-cell-apoptosis-through-the-induction-of-lysosomal-membrane-permeabilization
#7
JOURNAL ARTICLE
Yu Chen, Shanshan Zhu, Tianxing Liao, Chunxuan Wang, Jiajun Han, Zhenyu Yang, Xiaolong Lu, Zenglei Hu, Jiao Hu, Xiaoquan Wang, Min Gu, Ruyi Gao, Kaituo Liu, Xiaowen Liu, Chan Ding, Shunlin Hu, Xiufan Liu
Lysosomes are acidic organelles that mediate the degradation and recycling of cellular waste materials. Damage to lysosomes can cause lysosomal membrane permeabilization (LMP) and trigger different types of cell death, including apoptosis. Newcastle disease virus (NDV) can naturally infect most birds. Additionally, it serves as a promising oncolytic virus known for its effective infection of tumor cells and induction of intensive apoptotic responses. However, the involvement of lysosomes in NDV-induced apoptosis remains poorly understood...
February 2024: PLoS Pathogens
https://read.qxmd.com/read/38339315/phase-i-ii-trial-of-urokinase-plasminogen-activator-targeted-oncolytic-newcastle-disease-virus-for-canine-intracranial-tumors
#8
JOURNAL ARTICLE
John H Rossmeisl, Jamie N King, John L Robertson, James Weger-Lucarelli, Subbiah Elankumaran
Neurotropic oncolytic viruses are appealing agents to treat brain tumors as they penetrate the blood-brain barrier and induce preferential cytolysis of neoplastic cells. The pathobiological similarities between human and canine brain tumors make immunocompetent dogs with naturally occurring tumors attractive models for the study of oncolytic virotherapies. In this dose-escalation/expansion study, an engineered Lasota NDV strain targeting the urokinase plasminogen activator system (rLAS-uPA) was administered by repetitive intravenous infusions to 20 dogs with intracranial tumors with the objectives of characterizing toxicities, immunologic responses, and neuroradiological anti-tumor effects of the virus for up to 6 months following treatment...
January 29, 2024: Cancers
https://read.qxmd.com/read/38328418/recombinant-newcastle-disease-viruses-expressing-immunological-checkpoint-inhibitors-induce-a-pro-inflammatory-state-and-enhance-tumor-specific-immune-responses-in-two-murine-models-of-cancer
#9
JOURNAL ARTICLE
Lisa A Santry, Jacob P van Vloten, Amanda W K AuYeung, Robert C Mould, Jacob G E Yates, Thomas M McAusland, James J Petrik, Pierre P Major, Byram W Bridle, Sarah K Wootton
INTRODUCTION: Tumor microenvironments are immunosuppressive due to progressive accumulation of mutations in cancer cells that can drive expression of a range of inhibitory ligands and cytokines, and recruitment of immunomodulatory cells, including myeloid-derived suppressor cells (MDSC), tumor-associated macrophages, and regulatory T cells (Tregs). METHODS: To reverse this immunosuppression, we engineered mesogenic Newcastle disease virus (NDV) to express immunological checkpoint inhibitors anti-cytotoxic T lymphocyte antigen-4 and soluble programmed death protein-1...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38178138/the-artificial-amino-acid-change-in-the-sialic-acid-binding-domain-of-the-hemagglutinin-neuraminidase-of-newcastle-disease-virus-increases-its-specificity-to-hct-116-colorectal-cancer-cells-and-tumor-suppression-effect
#10
JOURNAL ARTICLE
Bo-Kyoung Jung, Yong Hee An, Sung Hoon Jang, Jin-Ju Jang, Seonhee Kim, Joo Hee Jeon, Jinju Kim, Jason Jungsik Song, Hyun Jang
BACKGROUND: Oncolytic viruses are being studied and developed as novel cancer treatments. Using directed evolution technology, structural modification of the viral surface protein increases the specificity of the oncolytic virus for a particular cancer cell. Newcastle disease virus (NDV) does not show specificity for certain types of cancer cells during infection; therefore, it has low cancer cell specificity. Hemagglutinin is an NDV receptor-binding protein on the cell surface that determines host cell tropism...
January 4, 2024: Virology Journal
https://read.qxmd.com/read/38100982/autophagy-inhibition-suppresses-newcastle-disease-virus-induced-cell-death-by-inhibiting-viral-replication-in-human-breast-cancer-cells
#11
JOURNAL ARTICLE
Megat Irfan Rozilah, Khatijah Yusoff, Suet Lin Chia, Saila Ismail
Newcastle disease virus (NDV) is an oncolytic virus which selectively replicates in cancer cells without harming normal cells. Autophagy is a cellular mechanism that breaks down unused cytoplasmic constituents into nutrients. In previous studies, autophagy enhanced NDV-induced oncolysis in lung cancer and glioma cells. However, the effect of autophagy inhibition on NDV-induced oncolysis in breast cancer cells remains unknown. This study aimed to examine the effect of autophagy inhibition on NDV-induced oncolysis in human breast cancer cells, MCF7...
December 7, 2023: Virology
https://read.qxmd.com/read/38041958/the-effects-of-the-lasota-strain-of-oncolytic-newcastle-disease-virus-vaccine-on-cervical-intraepithelial-neoplasia-patients-clinical-cohort-study
#12
JOURNAL ARTICLE
Neda Sharifi, Majid Bouzari, Hossein Keyvani, Mohammad Mehdi Ranjbar
BACKGROUND: Cervical cancer is one of the most common malignancies in women, and its treatment has many side effects. Therefore, in this research, the effects of the LaSota strain of oncolytic Newcastle disease virus vaccine on cervical intraepithelial neoplasia (CIN) patients were investigated. METHODS: 15 patients who met the inclusion criteria and diagnosed as CIN II and CIN III were included in the study. The vaccine was injected inside the cervix (neoplasia site) at increasing doses during 21 days, and they were evaluated for adverse events...
December 1, 2023: International Immunopharmacology
https://read.qxmd.com/read/38028532/editorial-oncolytic-virotherapy
#13
EDITORIAL
Ahmed Majeed Al-Shammari, Pier Paolo Piccaluga
No abstract text is available yet for this article.
2023: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/37974615/immune-responses-elicited-by-ssrna-oncolytic-viruses-in-the-host-and-in-the-tumor-microenvironment
#14
JOURNAL ARTICLE
Yonina Bykov, Gloria Dawodu, Aryana Javaheri, Adolfo Garcia-Sastre, Sara Cuadrado-Castano
Oncolytic viruses (OVs) are at the forefront of biologicals for cancer treatment. They represent a diverse landscape of naturally occurring viral strains and genetically modified viruses that, either as single agents or as part of combination therapies, are being evaluated in preclinical and clinical settings. As the field gains momentum, the research on OVs has been shifting efforts to expand our understanding of the complex interplay between the virus, the tumor and the immune system, with the aim of rationally designing more efficient therapeutic interventions...
2023: Journal of Cancer Metastasis and Treatment
https://read.qxmd.com/read/37803068/combined-oncolytic-virotherapy-gold-nanoparticles-as-synergistic-immunotherapy-agent-in-breast-cancer-control
#15
JOURNAL ARTICLE
Majid S Jabir, Ahmed M Al-Shammari, Zainab O Ali, Salim Albukhaty, Ghassan M Sulaiman, Sabrean F Jawad, Sawsan S Hamzah, Asad Syed, Abdallah M Elgorban, Rajalakshmanan Eswaramoorthy, Nouf S S Zaghloul, Ali G Al-Dulimi, Mazin A A Najm
Combining viruses and nanoparticles may be a way to successfully treat cancer and minimize adverse effects. The current work aimed to evaluate the efficacy of a specific combination of gold nanoparticles (GNPs) and Newcastle disease virus (NDV) to enhance the antitumor effect of breast cancer in both in vitro and in vivo models. Two human breast cancer cell lines (MCF-7 and AMJ-13) and a normal epithelial cell line (HBL-100) were used and treated with NDV and/or GNPs. The MTT assay was used to study the anticancer potentials of NDV and GNP...
October 6, 2023: Scientific Reports
https://read.qxmd.com/read/37720338/papaverine-enhances-the-oncolytic-effects-of-newcastle-disease-virus-on-breast-cancer-in-vitro-and-in-vivo
#16
JOURNAL ARTICLE
Sura Akram, Ahmed Majeed Al-Shammari, Hayder B Sahib, Majid Sakhi Jabir
Breast cancer is a lethal disease in females worldwide and needs effective treatment. Targeting cancer cells with selective and safe treatment seems like the best choice, as most chemotherapeutic drugs act unselectively. Papaverine showed promising antitumor activity with a high safety profile and increased blood flow through vasodilation. At the same time, it was widely noticed that virotherapy using the Newcastle disease virus proved to be safe and selective against a broad range of cancer cells. Furthermore, combination therapy is favorable, as it attacks cancer cells with multiple mechanisms and enhances virus entrance into the tumor mass, overcoming cancer cells' resistance to therapy...
2023: International Journal of Microbiology
https://read.qxmd.com/read/37654972/oncolytic-virotherapy-with-chimeric-vsv-ndv-synergistically-supports-rig-i-dependent-checkpoint-inhibitor-immunotherapy
#17
JOURNAL ARTICLE
Janina Marek, Lorenz Hanesch, Teresa Krabbe, Nadia El Khawanky, Simon Heidegger, Jennifer Altomonte
Unraveling the complexities of the tumor microenvironment (TME) and its correlation with responsiveness to immunotherapy has become a main focus in overcoming resistance to such treatments. Targeting tumor-intrinsic retinoic acid-inducible gene-I (RIG-I), a sensor for viral RNA, was shown to transform the TME from an immunogenically "cold" state to an inflamed, "hot" lesion, which we demonstrated previously to be a crucial mediator of the efficacy of immune checkpoint inhibition with anti-cytotoxic T lymphocyte-associated protein 4 (CTLA-4)...
September 21, 2023: Molecular Therapy Oncolytics
https://read.qxmd.com/read/37629483/the-viral-knock-ameliorating-cancer-treatment-with-oncolytic-newcastle-disease-virus
#18
REVIEW
Upasana Pathak, Ramprasad B Pal, Nagesh Malik
The prospect of cancer treatment has drastically transformed over the last four decades. The side effects caused by the traditional methods of cancer treatment like surgery, chemotherapy, and radiotherapy through the years highlight the prospect for a novel, complementary, and alternative cancer therapy. Oncolytic virotherapy is an evolving treatment modality that utilizes oncolytic viruses (OVs) to selectively attack cancer cells by direct lysis and can also elicit a strong anti-cancer immune response. Newcastle disease virus (NDV) provides a very high safety profile compared to other oncolytic viruses...
July 26, 2023: Life
https://read.qxmd.com/read/37578106/viral-vectors-expressing-interleukin-2-for-cancer-immunotherapy
#19
JOURNAL ARTICLE
Hongbin Wang, Mia Borlongan, Akseli Hemminki, Saru Basnet, Howard Kaufman, Samuel Rabkin, Dipongkor Saha
Interleukin 2 (IL-2) plays a crucial role in T-cell growth and survival, enhancing the cytotoxic activity of natural killer and cytotoxic T cells and thus functioning as a versatile master pro-inflammatory anti-cancer cytokine. The FDA has approved IL-2 cytokine therapy for the treatment of metastatic melanoma and metastatic renal cell carcinoma. However, IL-2 therapy has significant constraints, including a short serum half-life, low tumor accumulation, and life-threatening toxicities associated with high doses...
August 14, 2023: Human Gene Therapy
https://read.qxmd.com/read/37525229/antiproliferative-effects-of-mesenchymal-stem-cells-carrying-newcastle-disease-virus-and-lactobacillus-casei-extract-on-ct26-cell-line-synergistic-effects-in-cancer-therapy
#20
JOURNAL ARTICLE
Akbar Ghorbani Alvanegh, Majid Mirzaei Nodooshan, Ruhollah Dorostkar, Reza Ranjbar, Bahman Jalali Kondori, Alireza Shahriary, Karim Parastouei, Soheil Vazifedust, Elmira Afrasiab, Hadi Esmaeili Gouvarchinghaleh
BACKGROUND AND AIMS: Colorectal Cancer (CRC) is a frequent malignancy with a high mortality rate. Specific inherited and environmental influences can affect CRC. Oncolytic viruses and bacteria in treating CRC are one of the innovative therapeutic options. This study aims to determine whether mesenchymal stem cells (MSCs) infected with the Newcastle Disease Virus (NDV) in combination with Lactobacillus casei extract (L. casei) have a synergistic effects on CRC cell line growth. MATERIALS AND METHODS: MSCs taken from the bone marrow of BALB/c mice and were infected with the 20 MOI of NDV...
July 31, 2023: Infectious Agents and Cancer
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