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https://www.readbyqxmd.com/read/29350484/paraptosis-inducing-nanomedicine-overcomes-cancer-drug-resistance-for-a-potent-cancer-therapy
#1
Yongcun Zhou, Feiteng Huang, Ying Yang, Pingli Wang, Zhen Zhang, Yining Tang, Youqing Shen, Kai Wang
Most chemotherapeutic drugs and their nanomedicine formulations exert anticancer activity by inducing cancer cell apoptosis. However, cancer cells inherently have and acquire many antiapoptosis mechanisms, causing cancer drug resistance and poor prognoses in patients. Herein, a potent paraptosis-inducing nanomedicine is reported that causes quick nonapoptotic death of cancer cells, overcoming apoptosis-based resistance and effectively inhibiting drug-resistant tumor growth. The nanomedicine is composed of micelles made from an amphiphilic 8-hydroxyquinoline (HQ)-conjugate block copolymer with polyethylene glycol...
January 19, 2018: Small
https://www.readbyqxmd.com/read/29350064/comparison-of-hyaluronic-acid-based-micelles-and-polyethylene-glycol-based-micelles-on-reversal-of-multidrug-resistance-and-enhanced-anticancer-efficacy-in-vitro-and-in-vivo
#2
Jinling Wang, Ying Li, Lifang Wang, Xiaohui Wang, Pengfei Tu
Polyethylene glycol (PEG)-based block copolymer micelles and hyaluronic acid (HA)-based grafted copolymer micelles have been widely investigated in chemotherapy. In this study, to evaluate the differences among HA-based grafted polymer micelles, PEG-based block polymer micelles and the mixed of these two micelles in enhancing antitumor effects and overcoming MDR, two amphiphilic vitamin E succinate (VES) derivatives, HA VES (HA-g-VES) and PEG 2000 VES (TPGS2k), were applied as nanocarriers to prepare HA-VES micelles (HA-PMs), TPGS2k micelles (TPGS2k-PMs) and the mixed micelles (HA/TPGS2k-PMs) for the co-delivery of doxorubicin (DOX) and curcumin (Cur)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29348348/whole-genome-sequence-of-a-mycobacterium-goodii-isolate-from-a-pediatric-patient-in-south-africa
#3
Mushal Allam, Lavania Joseph, Farzana Ismail, Halima Said, Nazir A Ismail, Arshad Ismail, Senzo Mtshali, Florah Mnyameni, Pierre Goussard, Jade C Pekeur, Adré Lourens, Shaheed V Omar
We describe here the draft genome sequence of a Mycobacterium goodii isolate from a pediatric patient in Western Cape, South Africa. To our knowledge, this is the second reported genome of this rapidly growing nontuberculous mycobacterial species.
January 18, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29346070/key-pharmacovigilance-stakeholders-experiences-of-direct-patient-reporting-of-adverse-drug-reactions-and-their-prospects-of-future-development-in-the-european-union
#4
P Inácio, A Cavaco, E Allan, M Airaksinen
OBJECTIVES: In the European Union (EU), legislation allows patients to directly report adverse drug reactions (ADRs) to competent authorities. Five years after its implementation, patient reporting is not equal in all countries. This study aimed to explore key stakeholders' perceptions of patient reporting in four EU countries. STUDY DESIGN: Qualitative study design. METHODS: Twelve representatives from national pharmacovigilance centres and/or authorities as well as national pharmaceutical industry bodies in four EU countries participated in the study...
January 12, 2018: Public Health
https://www.readbyqxmd.com/read/29341617/enhancing-docetaxel-delivery-to-multidrug-resistant-cancer-cells-with-albumin-coated-nanocrystals
#5
Sheryhan F Gad, Joonyoung Park, Ji Eun Park, Gihan N Fetih, Sozan S Tous, Wooin Lee, Yoon Yeo
Intravenous delivery of poorly water-soluble anticancer drugs such as docetaxel (DTX) is challenging due to the low bioavailability and the toxicity related to solubilizing excipients. Colloidal nanoparticles are used as alternative carriers, but low drug loading capacity and circulation instability limit their clinical translation. To address these challenges, DTX nanocrystals (NCs) were prepared using Pluronic F127 as an intermediate stabilizer and albumin as a functional surface modifier, which were previously found to be effective in producing small and stable NCs...
January 17, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29340817/adenoma-detection-rate-metrics-in-colorectal-cancer-surveillance-colonoscopy
#6
Jamie M Tjaden, Jessica A Hause, Daniel Berger, Samantha K Duveneck, Shriram M Jakate, Bruce A Orkin, Elizabeth L Hubbard, Joshua E Melson
BACKGROUND: A target goal for screening adenoma detection rate (S-ADR) of ≥ 25% has been set to define high-quality colonoscopy performance. However, there is no current accepted target goal for ADR in colorectal cancer (CRC) surveillance. This makes quality assessment challenging when physicians perform cancer surveillance colonoscopy but minimal screening procedures. METHODS: In this cohort study, consecutive colonoscopies performed at either Rush University Medical Center or Rush Oak Park Hospital by a gastroenterologist or colorectal surgeon in average risk screening population and CRC surveillance population were reviewed retrospectively from 2006 to 2012 and prospectively from 2013 to 2016...
January 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29338273/adverse-drug-reactions-of-non-opioid-and-opioid-analgesics-reported-to-croatian-national-authority-from-2007-to-2014
#7
Petra Sunara, Darko Krnic, Livia Puljak
OBJECTIVE: Adverse drug reactions (ADRs) are commonly observed in the health services because of system weaknesses and individual errors. Analgesics are widely used and it can be expected that with the increased use one can expect increased number of ADRs of analgesics. The aim of this study was to analyze ADRs of non-opioid and opioid analgesics reported to the Croatian Agency for Medicinal Products and Medical Devices (HALMED) from 2007 to 2014. METHODS: HALMED provided data on generic drug name, year of the ADR report, type of report, institution, reporting person, patient's age, sex and ADR type...
November 2017: Acta Medica Academica
https://www.readbyqxmd.com/read/29337108/a-vascular-disrupting-agent-overcomes-tumor-multidrug-resistance-by-skewing-macrophage-polarity-toward-the-m1-phenotype
#8
Xueping Lei, Minfeng Chen, Xiaobo Li, Maohua Huang, Qiulin Nie, Nan Ma, Heru Chen, Nanhui Xu, Wencai Ye, Dongmei Zhang
Multidrug resistance (MDR) mediated by ATP-binding cassette (ABC) transporters is the major obstacle for chemotherapeutic success. Although attempts have been made to circumvent ABC transporter-mediated MDR in past decades, there is still no effective agent in clinic. Here, we identified a vascular disrupting agent, Z-GP-DAVLBH, that significantly inhibited the growth of multidrug-resistant human hepatoma HepG2/ADM and human breast cancer MCF-7/ADR tumor xenografts, although these cells were insensitive to Z-GP-DAVLBH in vitro...
January 11, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29336255/fast-screening-technology-for-drug-emergency-management-predicting-suspicious-snps-for-adr-with-information-theory-based-models
#9
Zhaohui Liang, Jun Liu, Jimmy Xiangji Huang, Xing Zeng
OBJECTIVE: The genetic polymorphism of Cytochrome P450 (CYP 450) is considered as one of the main causes for adverse drug reactions (ADRs). In order to explore the latent correlations between ADRs and potentially corresponding single-nucleotide polymorphism (SNPs) in CYP450, three algorithms based on information theory are used as the main method to predict the possible relation. METHODS: The study uses a retrospective case-control study to explore the potential relation of ADRs to specific genomic locations and single-nucleotide polymorphism (SNP)...
January 14, 2018: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/29333777/-retrospective-analysis-of-adverse-drug-reactions-in-stomatology-hospital-from-2014-to-2016
#10
Li Jia, Wang Jianli, Zhao Ke, Zhao Shaofeng
OBJECTIVE: This study aims to investigate the characteristics and general rules of adverse drug reactions (ADR) in a 3A-grade stomatology hospital for safe and rational drug use in clinical stomatology. METHODS: We retrospectively analyzed 52 ADR cases (1∶1.36, males∶females) reported in the West China Hospital of Stomatology of Sichuan University from 2014 to 2016 in terms of gender and age distributions, drug categories, and clinical manifestations. RESULTS: Eight kinds of drugs and antibiotics were predominately used [24 cases, 46...
December 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29332840/examining-patterns-of-multimorbidity-polypharmacy-and-risk-of-adverse-drug-reactions-in-chronic-obstructive-pulmonary-disease-a-cross-sectional-uk-biobank-study
#11
Peter Hanlon, Barbara I Nicholl, Bhautesh Dinesh Jani, Ross McQueenie, Duncan Lee, Katie I Gallacher, Frances S Mair
OBJECTIVE: This study aims: (1) to describe the pattern and extent of multimorbidity and polypharmacy in UK Biobank participants with chronic obstructive pulmonary disease (COPD) and (2) to identify which comorbidities are associated with increased risk of adverse drug reactions (ADRs) resulting from polypharmacy. DESIGN: Cross-sectional. SETTING: Community cohort. PARTICIPANTS: UK Biobank participants comparing self-reported COPD (n=8317) with no COPD (n=494 323)...
January 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29328433/peiminine-serves-as-an-adriamycin-chemosensitizer-in-gastric-cancer-by-modulating-the-egfr-fak-pathway
#12
Qianqian Tang, Yunfei Wang, Lanjing Ma, Meiling Ding, Tingyu Li, Yongzhan Nie, Zhengyi Gu
Gastric cancer (GC) is one of the most common malignancies of the digestive tract. Adriamycin (ADR) has been widely utilized in various chemotherapy regimens for treating GC, yet its long-term application may increase drug resistance resulting in treatment failure. Increasing evidence shows that bioactive natural products can be used as chemotherapeutic sensitizers that can significantly improve chemotherapy sensitivity. Peiminine (PMI) is a biologically active component extracted from Fritillaria walujewii Regel...
January 3, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29327413/itpa-activity-in-children-treated-by-azathioprine-relationship-to-the-occurrence-of-adverse-drug-reactions-and-inflammatory-response
#13
Antony Citterio-Quentin, Mustapha Moulsma, Marie-Paule Gustin, Alain Lachaux, Roselyne Boulieu
Azathioprine (AZA), a thiopurine drug, is widely used in the treatment of children with immunological disease such as inflammatory bowel disease (IBD) and autoimmune hepatitis (AIH); however, interindividual variability in the occurrence of adverse drug reaction (ADRs) and drug response is observed. This study investigated 1) the relationships between inosine triphosphate pyrophosphatase (ITPA) activity, an enzyme involved in thiopurine metabolism, and the occurrence of ADRs in children with immunological disease on AZA therapy, 2) the relationship between ITPA activity and the inflammatory activity observed in children with IBD...
January 11, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29325225/influence-of-cyp2d6-cyp3a4-cyp3a5-and-abcb1-polymorphisms-on-pharmacokinetics-and-safety-of-aripiprazole-in-healthy-volunteers
#14
Carmen Belmonte, Dolores Ochoa, Manuel Román, Miriam Saiz-Rodríguez, Aneta Wojnicz, Clara Isabel Gómez-Sánchez, Samuel Martín-Vilchez, Francisco Abad-Santos
The aim of this study was to investigate the effect of polymorphisms in cytochrome P450 (CYP) 2D6, CYP3A4 and CYP3A5 enzymes and in P-glycoprotein (P-gp) on the pharmacokinetics and safety of aripiprazole and, its active metabolite, dehydro-aripiprazole, in 148 healthy volunteers from 6 bioequivalence trials receiving a single oral dose of aripiprazole. The plasma concentrations of both analytes were measured by LC-MS/MS. CYP2D6 (*3,*4,*5,*6,*7,*9 and copy number variations), CYP3A4 (*20 and *22), CYP3A5*3 and C3435T, C1236T and G2677T/A in ABCB1 gene were determined...
January 11, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29318879/intelligent-mos2-nanotheranostic-for-targeted-and-enzyme-ph-nir-responsive-drug-delivery-to-overcome-cancer-chemotherapy-resistance-guided-by-pet-imaging
#15
Xinghua Dong, Wenyan Yin, Xiao Zhang, Shuang Zhu, Xiao He, Jie Yu, Jiani Xie, Zhao Guo, Liang Yan, Xiangfeng Liu, Qing Wang, Zhanjun Gu, Yuliang Zhao
Chemotherapy resistance remains a major hurdle for cancer therapy in clinic due to poor cellular uptake, insufficient intracellular release of drugs. Herein, an intelligent, multifunctional MoS2 nanotheranostic (MoS2-PEI-HA) ingeniously decorating with biodegradable hyaluronic acid (HA) assisted by polyethyleneimine (PEI) is reported to combat drug-resistant breast cancer (MCF-7-ADR) after loading with chemotherapy drug doxorubicin (DOX). The HA can not only target CD44-overexpressing MCF-7-ADR, but also be degraded by hyaluronidase (HAase) that is concentrated in the tumor microenvironment and thus to accelerate doxorubicin (DOX) release...
January 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29318003/incident-adverse-drug-reactions-in-geriatric-inpatients-a-multicentred-observational-study
#16
Amanda Lavan, Joseph Eustace, Darren Dahly, Evelyn Flanagan, Paul Gallagher, Shane Cullinane, Mirko Petrovic, Katrina Perehudoff, Adalsteinn Gudmondsson, Ólafur Samuelsson, Ástrós Sverrisdóttir, Antonio Cherubin, Frederica Dimitri, Joe Rimland, Alfonso Cruz-Jentoft, Manuel Vélez-Díaz-Pallarés, Isabel Lozano Montoya, Roy L Soiza, Selvarani Subbarayan, Denis O'Mahony
Background: Adverse drug reactions (ADRs) are common in older adults and frequently have serious clinical and economic consequences. This study was conducted as a feasibility study for a randomized control trial (RCT) that will investigate the efficacy of a software engine to optimize medications and reduce incident (in-hospital) ADRs. This study's objectives were to (i) establish current incident ADR rates across the six sites participating in the forthcoming RCT and (ii) assess whether incident ADRs are predictable...
January 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29314567/antegrade-fenestration-and-re-entry-a-new-controlled-subintimal-technique-for-chronic-total-occlusion-recanalization
#17
Mauro Carlino, Lorenzo Azzalini, Satoru Mitomo, Antonio Colombo
OBJECTIVES: To describe and evaluate the efficacy of a novel antegrade dissection/re-entry (ADR) technique, called antegrade fenestration and re-entry (AFR), for chronic total occlusions (CTO) percutaneous coronary intervention (PCI). BACKGROUND: The widespread adoption of ADR is limited by several technical, logistic, and financial factors. Therefore, novel ADR techniques are needed. METHODS: AFR consists in creating multiple fenestrations of the dissection flap separating the false and true lumen...
January 4, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29314262/adverse-drug-reactions-of-analgesic-medicines-analysis-of-the-romanian-pharmacovigilance-database
#18
Irina Cazacu, Roxana Stroe, Roxana Dondera, Cristina Mogosan, Françoise Haramburu, Annie Fourrier-Réglat, Felicia Loghin
The results of national safety studies are essential for decision-making at the regulatory level and have also educational implications for prescribing patterns. The aim of the present study was to analyze the ADRs of analgesic medicines spontaneously reported to Pharmacovigilance and Risk Management Service of the Romanian National Agency for Medicines and Medical Devices between 2011 and 2015. For the 71 reports, patients had a mean age of 39.8 years; 60.6% of patients were female, 38% male and 1.4% were unknown...
January 4, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29313952/how-to-consider-rare-genetic-variants-in-personalized-drug-therapy
#19
Volker M Lauschke, Magnus Ingelman-Sundberg
Personalized drug therapy aims to optimize the efficacy of pharmacological treatments by considering genetic, pathophysiological, dietary, and environmental factors as well as comedications and compliance. A multitude of associations between the specific genetic constitution of the patient and drug pharmacokinetics and pharmacodynamics has been identified in the last decades that encompass mainly common single nucleotide variants (SNVs) and gene copy number variations (CNVs) of importance for the function of genes encoding drug-metabolizing enzymes and transporters involved in drug absorption, distribution, metabolism, and excretion (ADME)...
January 5, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29310415/cisplatin-induced-sudden-cardiac-death-with-hemodynamic-collapse-a-severe-adverse-drug-reaction-case-report
#20
Silvijus Abramavicius, Marius Zemaitis, Vidas Pilvinis, Edmundas Kadusevicius
RATIONALE: Cisplatin is responsible for a significant percentage of adverse drug reactions (ADRs) in oncology setting. A great proportion of cisplatin-induced severe adverse events are difficult to foresee, and giving premedication does not always prevent the occurrence of such events. PATIENT CONCERNS: A 53-year-old woman with progressive T4 N0 M0 stage IV pleural mesothelioma experienced cardiac arrest with hemodynamic collapse after cisplatin and pemetrexed chemotherapy administration...
December 2017: Medicine (Baltimore)
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