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https://www.readbyqxmd.com/read/28088378/antimicrobial-coated-implants-in-trauma-and-orthopaedics-a-clinical-review-and-risk-benefit-analysis
#1
REVIEW
Volker Alt
Implant-associated infections remain a major issue in orthopaedics and antimicrobial functionalization of the implant surface by antibiotics or other anti-infective agents have gained interest. The goal of this article is to identify antimicrobial coatings, for which clinical data are available and to review their clinical need, safety profile, and their efficacy to reduce infection rates. PubMed database of the National Library of Medicine was searched for clinical studies on antimicrobial coated implants for internal fracture fixation devices and endoprostheses for bone surgery, for which study design, level of evidence, biocompatibility, development of resistance, and effectiveness to reduce infection rates were analyzed...
December 21, 2016: Injury
https://www.readbyqxmd.com/read/28087018/a-case-of-onychomatricoma-classic-clinical-dermoscopic-and-nail-clipping-histologic-findings
#2
Lauren Goldlust Okon, Nazanin Saedi, Laurel Schwartz, Jason B Lee
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28079929/the-impact-of-age-on-psoriasis-health-care-in-germany
#3
A Trettel, C Spehr, A Körber, M Augustin
INTRODUCTION: Inequality between age groups has been demonstrated in the prescription of biologics, yet systematic real-world data about age-related differences in psoriasis care are missing. OBJECTIVE: To investigate disparities in psoriasis characteristics by age groups and to identify potential impact on psoriasis health care. PATIENTS AND METHODS: Data analysis included 3,615 patients from the German Psoriasis registry PsoBest, which observes adult patients with moderate to severe psoriasis or psoriatic arthritis (PsA) on systemic treatment over a time period of 10 years...
January 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28078732/a-fleshy-growth-below-the-nail-plate-in-an-elderly-man
#4
Neetu Bhari, Vinod K Sharma, B Lal Jangid, Sudheer Arava, Anurag Srivastava
No abstract text is available yet for this article.
January 11, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28077901/feasibility-and-value-of-radiographic-union-score-hip-fracture-after-treatment-with-intramedullary-nail-of-stable-hip-fractures
#5
Daniele Maiettini, Michele Bisaccia, Auro Caraffa, Giuseppe Rinonapoli, Luigi Piscitelli, Olga Bisaccia, Giuseppe Rollo, Luigi Meccariello, Paolo Ceccarini, Alberto Rebonato
INTRODUCTION: Given the importance of fracture healing on patient outcome in clinical practice, it is critical to assess fracture healing. AIM: The aim of this study was to evaluate the feasibility of the Radiographic Union Score Hip fracture after treatment with intramedullary nail of stable hip fractures. PATIENTS AND METHODS: We retrospectively collected the data from the clinical records of our institution of the 47 patientswho had undergone intertrochanteric hip fracture treatment using an intramedullary nail...
December 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28077132/foxn1-deficient-nude-severe-combined-immunodeficiency
#6
REVIEW
Ioanna A Rota, Fatima Dhalla
Nude severe combined immunodeficiency is a rare inherited disease caused by autosomal recessive loss-of-function mutations in FOXN1. This gene encodes a transcription factor essential for the development of the thymus, the primary lymphoid organ that supports T-cell development and selection. To date nine cases have been reported presenting with the clinical triad of absent thymus resulting in severe T-cell immunodeficiency, congenital alopecia universalis and nail dystrophy. Diagnosis relies on testing for FOXN1 mutations, which allows genetic counselling and guides therapeutic management...
January 11, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28076469/scoring-clinical-signs-can-help-diagnose-canine-visceral-leishmaniasis-in-a-highly-endemic-area-in-brazil
#7
Kleverton Ribeiro da Silva, Vitor Rosa Ramos de Mendonça, Kellen Matuzzy Silva, Leopoldo Fabrício Marçal do Nascimento, Antonio Ferreira Mendes-Sousa, Flaviane Alves de Pinho, Manoel Barral-Netto, Aldina Maria Prado Barral, Maria do Socorro Pires E Cruz
Canine visceral leishmaniasis (CVL) diagnosis is still a challenge in endemic areas with limited diagnostic resources. This study proposes a score with the potential to distinguish positive CVL cases from negative ones. We studied 265 dogs that tested positive for CVL on ELISA and parasitological tests. A score ranging between 0 and 19 was recorded on the basis of clinical signs. Dogs with CVL had an overall higher positivity of the majority of clinical signs than did dogs without CVL or with ehrlichiosis. Clinical signs such as enlarged lymph nodes (83...
January 1, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28074263/treatment-options-and-outcome-after-bony-avulsion-of-the-flexor-digitorum-profundus-tendon-a-review-of-29-cases
#8
Gabriel Halát, Lukas Negrin, Jochen Erhart, Robin Ristl, Stefan Hajdu, Patrick Platzer
INTRODUCTION: The objective of this retrospective review was to evaluate the functional and esthetic outcomes in patients with non- or minimally (<2 mm), and severely (>2 mm) displaced bony avulsions of the flexor digitorum profundus (FDP) tendon. MATERIALS AND METHODS: Between 1996 and 2010, 29 patients with a bony avulsion of the FDP tendon were treated. The displacement magnitude of the avulsed fragment determined, whether conservative or surgical treatment was performed...
January 10, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28073094/the-role-of-lesser-trochanter-fragment-in-unstable-pertrochanteric-a2-proximal-femur-fractures-is-refixation-of-the-lesser-trochanter-worth-the-effort
#9
Christian Ehrnthaller, Alain Christoph Olivier, Florian Gebhard, Lutz Dürselen
BACKGROUND: Instability of osteoporotic pertrochanteric fractures is defined by loss of medial/lateral cortical integrity with the posteromedial fragment including the lesser trochanter being pivotal for load distribution. Literature addressing the importance of lesser trochanter refixation is scarce. To clarify the effect of lesser trochanter refixation on primary stability in these fractures, following study was performed. METHODS: 21 femora were match-paired in 3 groups and osteotomized, creating pertrochanteric fractures (AO-31A2)...
December 30, 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/28072652/in-vivo-correlation-of-radiographic-scoring-rust-and-biomechanical-data-in-a-sheep-osteotomy-model-can-we-define-union-radiographically
#10
Paul Tornetta, Jody Litrenta, William Ricci, Roy Sanders, Robert V O'Toole, Jason W Nascone, Henry Faber, Darren Wilson
OBJECTIVE: To determine 1) the reliability of the standard and modified RUST score in a sheep osteotomy model, and 2) the standard and modified RUST score that represents biomechanical union. DESIGN: The tibia cortices in a sheep osteotomy model treated by intramedullary nails were radiographically evaluated using standard and modified RUST scores. Scores that correlated with biomechanical union, based on the torsional stiffness of the contralateral tibia, were determined...
December 22, 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28069297/lesions-on-the-back-of-hands-and-female-gender-predispose-to-stigmatization-in-patients-with-psoriasis
#11
Marlena Hawro, Marcus Maurer, Karsten Weller, Romuald Maleszka, Anna Zalewska-Janowska, Andrzej Kaszuba, Zofia Gerlicz-Kowalczuk, Tomasz Hawro
BACKGROUND: Psoriasis vulgaris is characterized by disfiguring and stigmatizing skin lesions. The links among lesions distribution, severity, and stigmatization remain unclear. OBJECTIVE: We sought to investigate if the involvement of visible and sensitive areas is linked to stigmatization. METHODS: In all, 115 patients with psoriasis vulgaris were assessed for disease severity, skin lesions distribution, itch, and stigmatization using the Feelings of Stigmatization Questionnaire...
January 6, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28067928/near-infrared-light-mediated-enhancement-of-reactive-oxygen-species-generation-through-electron-transfer-from-graphene-oxide-to-iron-hydroxide-oxide
#12
Yue He, Andrea Del Valle, Yu Qian, Yu-Fen Huang
Clinical applications of current photodynamic therapy (PDT) agents are often restricted to be activated only by UV and visible light, which have very poor tissue penetration depths. In this study, a new near infrared (NIR)-absorbing nanoagent based on graphene oxide decorated with iron hydroxide/oxide (GO-FeOxH) was developed for light-activated nanomaterial-mediated PDT. This nanocomposite, GO-FeOxH was prepared via the one-step electrooxidation of iron nails in an aqueous GO solution. The as-prepared GO-FeOxH showed a much higher reactive oxygen species (ROS) activity under NIR light irradiation than GO...
January 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/28067894/unexpected-uvr-and-non-uvr-mutation-burden-in-some-acral-and-cutaneous-melanomas
#13
Robert V Rawson, Peter A Johansson, Nicholas K Hayward, Nicola Waddell, Ann-Marie Patch, Serigne Lo, John V Pearson, John F Thompson, Graham J Mann, Richard A Scolyer, James S Wilmott
Ultraviolet radiation (UVR) mutagenesis causes nearly all cutaneous melanomas, however, since UVR signatures are largely absent in acral melanoma, as well as melanoma in sun-protected sites, the cause of these melanomas is unknown. Whole-genome sequencing data generated as part of the Australian Melanoma Genome Project was supplemented with a detailed histopathological assessment with the melanomas then classified as UVR or non-UVR related, based on their mutation signatures. The clinicopathological characteristics of melanomas with mutation signatures for their subtype were compared...
January 9, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28064351/orthopedic-trauma-surgery-and-hospital-cost-analysis-in-refugees-the-effect-of-the-syrian-civil-war
#14
Altuğ Duramaz, Mustafa Gökhan Bilgili, Berhan Bayram, Nezih Ziroğlu, Alkan Bayrak, Mustafa Cevdet Avkan
PURPOSE: The aim of this study was to evaluate the musculoskeletal injury types, injury mechanisms, surgical techniques and treatment costs of Syrian refugees. METHODS: Totally 158 patients (67 female, 91 male) treated in our clinic in 34 months period between January 2012 and October 2014 were included in the study. The mean age of the patients was 39.3 years (range: 18-82 years). The patients were evaluated for age, gender, mechanism of injury, location and type of fracture, presence of accompanying injuries, injury severity score, surgical technique, complications, mortality/morbidity and treatment cost...
January 7, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28064275/yellow-nail-syndrome
#15
Shricharith Shetty, Nalini Bhaskaranand
No abstract text is available yet for this article.
December 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/28063967/an-innovative-polysaccharide-nanobased-nail-formulation-for-improvement-of-onychomycosis-treatment
#16
Fernanda C Flores, Roberta S Rosso, Letícia Cruz, Ruy C R Beck, Cristiane B Silva
Tioconazole-loaded nanocapsule suspensions and its coating with a cationic polymer were developed for nail drug delivery. The colloidal systems presented a nanometric size around 155nm for uncoated nanoparticles and 162nm for those with the cationic coating, with negative and positive zeta potential values, respectively. Both nanosuspensions showed drug content close to theoretical values (1mgmL(-1)), association efficiency close to 100% (HPLC) and were able to control tioconazol release. The developed formulations showed in vitro antifungal activity (agar diffusion method) against C...
January 4, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28063594/-scabies-of-the-nail-unit-in-an-infant
#17
A Finon, G Desoubeaux, M Nadal, G Georgescou, R Baran, A Maruani
BACKGROUND: There are no guidelines regarding the management of scabies in infants and recurrence is common at this age. We report the case of an infant with subungual hyperkeratosis and ungual lesions subsequent to classic scabies. PATIENTS AND METHODS: A 7-month-girl, treated 6 weeks earlier with esdepallethrin for scabies, consulted for acquired lesions on 3 toe nails. These nails were thickened and displayed subungual hyperkeratosis. Physical examination of the skin, the finger nails and mucous membranes was otherwise normal...
January 4, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28061322/long-pulsed-1064-nm-nd-yag-laser-for-the-treatment-of-onychomycosis
#18
Domenico Piccolo, Dimitra Kostaki, Ester Del Duca, Giovanni Cannarozzo, Mario Sannino, Steven Nisticò
OBJECTIVE: The aim of this study is to evaluate the efficacy of long-pulsed 1064-nm Nd:YAG laser in penetrating tissue and targeting the fungal overgrowth in the nail plate. BACKGROUND: Onychomycosis is the most frequent nail disorder. Current treatments include oral and topical antifungal agents, photodynamic therapy, and surgical approaches such as mechanical, chemical, or surgical nail avulsion. Moreover, the use of lasers to treat nail diseases has been approved in the United States by the Food and Drug Administration (FDA)...
December 30, 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28059656/midterm-results-of-t-stent-assisted-coiling-of-wide-necked-and-complex-intracranial-bifurcation-aneurysms-using-low-profile-stents
#19
Kubilay Aydin, Serra Sencer, Mehmet Barburoglu, Mynzhylky Berdikhojayev, Yavuz Aras, Altay Sencer, Nail İzgi
OBJECTIVE Coiling of wide-necked and complex bifurcation aneurysms frequently requires implantation of double stents in various configurations. T-stent-assisted coiling involves the nonoverlapping implantation of 2 stents to protect the daughter vessels of bifurcation and is followed by coiling of the aneurysm. The authors studied the feasibility, efficacy, and safety of the T-stent-assisted coiling procedure as well as the midterm angiographic/clinical outcomes of patients with wide-necked bifurcation intracranial aneurysms treated using this technique...
January 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28059119/dysregulation-of-wti-kts-is-associated-with-the-kidney-specific-effects-of-the-lmx1b-r246q-mutation
#20
Gentzon Hall, Brandon Lane, Megan Chryst-Ladd, Guanghong Wu, Jen-Jar Lin, XueJun Qin, Elizabeth R Hauser, Rasheed Gbadegesin
Mutations in the LIM homeobox transcription factor 1-beta (LMX1B) are a cause of nail patellar syndrome, a condition characterized by skeletal changes, glaucoma and focal segmental glomerulosclerosis. Recently, a missense mutation (R246Q) in LMX1B was reported as a cause of glomerular pathologies without extra-renal manifestations, otherwise known as nail patella-like renal disease (NPLRD). We have identified two additional NPLRD families with the R246Q mutation, though the mechanisms by which LMX1BR246Q causes a renal-specific phenotype is unknown...
January 6, 2017: Scientific Reports
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