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Niklas F Boeder, Oliver Dörr, Johannes Rixe, Kay Weipert, Timm Bauer, Matthias Bayer, Christian W Hamm, Holger M Nef
BACKGROUND: The MitraClip procedure can be an alternative treatment option for patients with high surgical risk for whom surgical treatment is contraindicated. Patients with prosthetic material have an increased risk for infective endocarditis. HYPOTHESIS: Incidence, treatment and outcome of patients with endocarditis after interventional mitral valve repair are not known. METHODS: We searched for articles using PubMed using the terms "interventional mitral valve repair", "mitraclip" and "endocarditis"...
November 10, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Kaixin Li, Yibo Yan, Jun Zhao, Junxi Lei, Xinli Jia, Samir H Mushrif, Yanhui Yang
Brønsted acidic ionic liquids (BAILs) can play a dual role, as a solvent and as a catalyst, in many reactions. However, molecular details of the catalytic mechanism are poorly understood. We present here a density functional theory (DFT) study for the catalytic mechanism of the transesterification of methyl ester (ME) with trimethylolpropane (TMP), in the presence of three representative BAILs, namely, N-methylimidazole-IL, pyridinium-IL, and triethylamine-IL. The deprotonation of the BAIL cation and the transesterification step are investigated...
November 23, 2016: Physical Chemistry Chemical Physics: PCCP
Jingyi Xue, Jianqiang Li, Hongjun Wang, Li Sheng, Yongtai Gong, Danghui Sun, Shuang Li, Weimin Li, Dingyu Wang, Yue Li
BACKGROUND: Inability to advance a balloon is a well-recognized cause leading to a failure in recanalization of chronic total occlusions (CTOs) despite successfully passing a guidewire. A few techniques and devices have been introduced to facilitate balloon passage, especially the use of Tornus catheter. However, complex manipulation, expensive cost, and availability limit the application of these methods. This study was to evaluate the efficiency and safety of "seesaw balloon-wire cutting" technique in comparison with Tornus catheter for balloon uncrossable CTOs...
November 2, 2016: International Journal of Cardiology
Ismail Dogu Kilic, Enrico Fabris, Roberta Serdoz, Gianluca Caiazzo, Nicolas Foin, Sara Abou-Sherif, Carlo Di Mario
Covered stents offer an effective bail-out strategy in vessel perforations, are an alternative to surgery for the exclusion of coronary aneurysms, and have a potential role in the treatment of friable embolisation-prone plaques. The aim of this manuscript is to offer an overview of currently available platforms and to report results obtained in prior studies.
November 20, 2016: EuroIntervention
V Ravi, R M Shannon, M Bailes, K Bannister, S Bhandari, N D R Bhat, S Burke-Spolaor, M Caleb, C Flynn, A Jameson, S Johnston, E F Keane, M Kerr, C Tiburzi, A V Tuntsov, H K Vedantham
Fast radio bursts (FRBs) are millisecond-duration events thought to originate beyond the Milky Way galaxy. Uncertainty surrounding the burst sources, and their propagation through intervening plasma, has limited their use as cosmological probes. We report on a mildly dispersed (dispersion measure 266.5 ± 0.1 pc cm(-3)), exceptionally intense (120 ± 30 Jy), linearly polarized, scintillating burst (FRB 150807) that we directly localize to 9 arcmin(2) Based on a low Faraday rotation (12.0 ± 0.7 rad m(-2)), we infer negligible magnetization in the circum-burst plasma and constrain the net magnetization of the cosmic web along this sightline to <21 nG, parallel to the line-of-sight...
November 17, 2016: Science
Jacyra Antunes Dos Santos Gomes, Juliana Félix-Silva, Júlia Morais Fernandes, Juliano Geraldo Amaral, Norberto Peporine Lopes, Eryvaldo Sócrates Tabosa do Egito, Arnóbio Antônio da Silva-Júnior, Silvana Maria Zucolotto, Matheus de Freitas Fernandes-Pedrosa
Snakebites are a serious worldwide public health problem. In Brazil, about 90% of accidents are attributed to snakes from the Bothrops genus. The specific treatment consists of antivenom serum therapy, which has some limitations such as inability to neutralize local effects, difficult access in some regions, risk of immunological reactions, and high cost. Thus, the search for alternative therapies to treat snakebites is relevant. Jatropha mollissima (Euphorbiaceae) is a medicinal plant popularly used in folk medicine as an antiophidic remedy...
2016: BioMed Research International
Roland Biber, Johannes Pauser, Markus Geßlein, Hermann Josef Bail
MAGNEZIX® (Syntellix AG, Hanover, Germany) is a biodegradable magnesium-based alloy (MgYREZr) which is currently used to manufacture bioabsorbable compression screws. To date, there are very few studies reporting on a limited number of elective foot surgeries using this innovative implant. This case report describes the application of this screw for osteochondral fracture fixation at the humeral capitulum next to a loose radial head prosthesis, which was revised at the same time. The clinical course was uneventful...
2016: Case Reports in Orthopedics
Bénédicte Neven, Philippe Pérot, Julie Bruneau, Marlene Pasquet, Marie Ramirez, Jean-Sébastien Diana, Stéphanie Luzi, Nicole Corre-Catelin, Christophe Chardot, Despina Moshous, Stéphanie Leclerc Mercier, Nizar Mahlaoui, Nathalie Aladjidi, Brigitte Le Bail, Marc Lecuit, Christine Bodemer, Thierry Jo Molina, Stéphane Blanche, Marc Eloit
Persistence of rubella live vaccine has been associated with chronic skin granuloma in 3 children with primary immunodeficiency. We describe 6 additional children with these findings, including 1 with visceral extension to the spleen.
October 6, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Ahmed Amro, Alaa Gabi, Adee Elhamdani, Naveed Iqbal, Mehiar El-Hamdani
Introduction. Retrograde pedal access has been well described in the literature as a secondary approach for limb salvage in critical limb ischemia (CLI) patients. In this manuscript we are presenting a case where retrograde tibiopedal access has been used as a bail-out procedure for the management of superficial femoral artery (SFA) intervention complications. Procedure/Technique. After development of a perforation while trying to cross the totally occluded mid SFA using the conventional CFA access, we were able to cross the mid SFA lesion after accessing the posterior tibial artery in a retrograde fashion and delivered a self-expanding stent which created a flap that sealed the perforation without the need for covered stent...
2016: Case Reports in Vascular Medicine
Takeshi Sugimoto, Tetsuya Nomura, Daisuke Miyawaki, Taku Kato, Natsuya Keira, Tetsuya Tatsumi
We encountered a case of blow-out type coronary perforation at the calcified stenosis of left anterior descending artery. First, we started immediate balloon tamponade through the initial guiding catheter (GC) with a GuideLiner(®) catheter. Next, we introduced a second GC with a GuideLiner(®) catheter and successfully deployed a covered stent. Two sets of the GC with GuideLiner(®) catheter facilitated us to simultaneously perform temporary hemostasis with balloon tamponade and rapid delivery of a covered stent...
October 31, 2016: Cardiovascular Intervention and Therapeutics
Julian E Bailes, Vimal Patel, Hamad Farhat, Brian Sindelar, James Stone
No abstract text is available yet for this article.
October 28, 2016: Journal of Neurosurgery. Pediatrics
Michael P Loosemore, Charles F Butler, Abdelhamid Khadri, David McDonagh, Vimal Patel, Julian E Bailes
No abstract text is available yet for this article.
October 21, 2016: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Paul Catley, Lisa Claydon
This examination of the extent of the use of neuroscientific evidence in England and Wales identifies 204 reported cases in which such evidence has been used by those accused of criminal offenses during the eight-year period from 2005-12. Based on the number of reported cases found, the use of such evidence appears well established with those accused of criminal offenses utilizing such evidence in approximately 1 per cent of cases in the Court of Appeal (Criminal Division). Neuroscientific evidence is used to quash convictions, to lead to convictions for lesser offenses and to lead to reduced sentences...
November 2015: Journal of Law and the Biosciences
Guoxu Zheng, Weimiao Li, Baile Zuo, Zhangyan Guo, Wenjin Xi, Ming Wei, Peng Chen, Weihong Wen, An-Gang Yang
CREPT (cell cycle-related and expression elevated protein in tumor) is highly expressed in many kinds of cancer, and has been shown to be prognostic in certain cancers. However, the clinical significance of CREPT in colorectal cancer (CRC) has not been sufficiently investigated. In this study, we examined the CREPT expression in 225 clinical CRC tissues and paired adjacent normal tissues, and analyzed the correlation between CREPT expression and other clinicopathological features. We also evaluated the biological function of CREPT both in vitro and in vivo using knockdown or overexpressing CRC cells...
October 20, 2016: Biochemical and Biophysical Research Communications
Michael W Collins, Anthony P Kontos, David O Okonkwo, Jon Almquist, Julian Bailes, Mark Barisa, Jeffrey Bazarian, O Josh Bloom, David L Brody, Robert Cantu, Javier Cardenas, Jay Clugston, Randall Cohen, Ruben Echemendia, R J Elbin, Richard Ellenbogen, Janna Fonseca, Gerard Gioia, Kevin Guskiewicz, Robert Heyer, Gillian Hotz, Grant L Iverson, Barry Jordan, Geoffrey Manley, Joseph Maroon, Thomas McAllister, Michael McCrea, Anne Mucha, Elizabeth Pieroth, Kenneth Podell, Matthew Pombo, Teena Shetty, Allen Sills, Gary Solomon, Danny G Thomas, Tamara C Valovich McLeod, Tony Yates, Ross Zafonte
BACKGROUND: Conventional management for concussion involves prescribed rest and progressive return to activity. Recent evidence challenges this notion and suggests that active approaches may be effective for some patients. Previous concussion consensus statements provide limited guidance regarding active treatment. OBJECTIVE: To describe the current landscape of treatment for concussion and to provide summary agreements related to treatment to assist clinicians in the treatment of concussion...
December 2016: Neurosurgery
Minzhen Deng, Liping Huang, Baile Ning, Nanbu Wang, Qinxin Zhang, Caixia Zhu, Yongqi Fang
Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly, and studies have suggested that β-asarone has pharmacological effects on beta-amyloid (Aβ) injected in the rat hippocampus. However, the effect of β-asarone on autophagy in the APP/PS1 transgenic mouse is unreported. APP/PS1 transgenic mice were randomly divided into six groups (n=10/group): an untreated group, an Aricept-treated group, a 3-MA-treated group, a rapamycin-treated group, an LY294002-treated group, a β-asarone-treated group...
October 10, 2016: Brain Research
Ryan C Turner, Brandon P Lucke-Wold, Matthew J Robson, John M Lee, Julian E Bailes
BACKGROUND: Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE) have long been recognized as sharing some similar neuropathological features, mainly the presence of neurofibrilary tangles and hyperphosphorylated tau, but have generally been described as distinct entities. Evidence indicates that neurotrauma increases the risk of developing dementia and accelerates the progression of disease. Findings are emerging that CTE and AD may be present in the same patients. CLINICAL PRESENTATION: This study presents a series of previously unpublished cases, with one case demonstrating possible neurotrauma-related AD, one pure CTE, and an example of a case exhibiting features of both AD and CTE...
August 11, 2016: Brain Injury: [BI]
Boon Kin Teh, Siew Ann Cheong
The Global Financial Crisis of 2007-2008 wiped out US$37 trillions across global financial markets, this value is equivalent to the combined GDPs of the United States and the European Union in 2014. The defining moment of this crisis was the failure of Lehman Brothers, which precipitated the October 2008 crash and the Asian Correction (March 2009). Had the Federal Reserve seen these crashes coming, they might have bailed out Lehman Brothers, and prevented the crashes altogether. In this paper, we show that some of these market crashes (like the Asian Correction) can be predicted, if we assume that a large number of adaptive traders employing competing trading strategies...
2016: PloS One
Brandon P Lucke-Wold, Aric F Logsdon, Linda Nguyen, Ahmed Eltanahay, Ryan C Turner, Patrick Bonasso, Chelsea Knotts, Adam Moeck, Joseph C Maroon, Julian E Bailes, Charles L Rosen
Studies using traditional treatment strategies for mild traumatic brain injury (TBI) have produced limited clinical success. Interest in treatment for mild TBI is at an all time high due to its association with the development of chronic traumatic encephalopathy and other neurodegenerative diseases, yet therapeutic options remain limited. Traditional pharmaceutical interventions have failed to transition to the clinic for the treatment of mild TBI. As such, many pre-clinical studies are now implementing non-pharmaceutical therapies for TBI...
October 5, 2016: Nutritional Neuroscience
Arnaud Desclaux, Marie-Catherine Receveur, Amandine Lechot, Brigitte Le Bail, Denis Malvy
No abstract text is available yet for this article.
October 1, 2016: Travel Medicine and Infectious Disease
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