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https://www.readbyqxmd.com/read/28446457/consensus-statement-on-concussion-in-sport-the-5-th-international-conference-on-concussion-in-sport-held-in-berlin-october-2016
#1
Paul McCrory, Willem Meeuwisse, Jiří Dvorak, Mark Aubry, Julian Bailes, Steven Broglio, Robert C Cantu, David Cassidy, Ruben J Echemendia, Rudy J Castellani, Gavin A Davis, Richard Ellenbogen, Carolyn Emery, Lars Engebretsen, Nina Feddermann-Demont, Christopher C Giza, Kevin M Guskiewicz, Stanley Herring, Grant L Iverson, Karen M Johnston, James Kissick, Jeffrey Kutcher, John J Leddy, David Maddocks, Michael Makdissi, Geoff Manley, Michael McCrea, William P Meehan, Sinji Nagahiro, Jon Patricios, Margot Putukian, Kathryn J Schneider, Allen Sills, Charles H Tator, Michael Turner, Pieter E Vos
No abstract text is available yet for this article.
April 26, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28426758/traces-of-business-cycles-in-credit-rating-migrations
#2
Dmitri Boreiko, Serguei Kaniovski, Yuri Kaniovski, Georg Pflug
Using migration data of a rating agency, this paper attempts to quantify the impact of macroeconomic conditions on credit-rating migrations. The migrations are modeled as a coupled Markov chain, where the macroeconomic factors are represented by unobserved tendency variables. In the simplest case, these binary random variables are static and credit-class-specific. A generalization treats tendency variables evolving as a time-homogeneous Markov chain. A more detailed analysis assumes a tendency variable for every combination of a credit class and an industry...
2017: PloS One
https://www.readbyqxmd.com/read/28406974/resveratrol-reduces-the-apoptosis-induced-by-cigarette-smoke-extract-by-upregulating-mfn2
#3
Chao Song, Bailing Luo, Li Gong
PURPOSE: The aim of this study was to investigate the effect of resveratrol (RSV) on cigarette smoke extract (CSE)-induced cell apoptosis and mitochondrial dysfunction in vitro, as well as changes in the MFN2 expression level. METHODS: Cultured human bronchial epithelial (HBE) cells were initially treated with CSE to induce apoptosis, followed by incubation either with or without RSV. Numerous techniques were used to evaluate the outcomes of the present study, including a cell counting kit-8 assay, real-time quantitative polymerase chain reaction (real-time qPCR), western blotting, JC-1 fluorescence, Hoechst 33342 staining, Annexin V-PI flow cytometry apoptosis analyses, and siRNA technology...
2017: PloS One
https://www.readbyqxmd.com/read/28403562/feasibility-safety-and-efficacy-of-transcatheter-aortic-valve-replacement-without-balloon-predilation-a-systematic-review-and-meta-analysis
#4
Vincent Auffret, Ander Regueiro, Francisco Campelo-Parada, María Del Trigo, Olivier Chiche, Chekrallah Chamandi, Rishi Puri, Josep Rodés-Cabau
OBJECTIVES: To evaluate the feasibility, safety, and efficacy of direct transcatheter aortic valve replacement (TAVR), that is, TAVR without balloon predilation (BPD), by performing a systematic review and meta-analysis of available evidence. BACKGROUND: Avoiding BPD during TAVR was shown to be feasible in previous studies but the risks and benefits of this technique are unknown owing to the limited number of patients included in these studies. METHODS: We performed a systematic search for studies comparing direct TAVR vs TAVR performed with BPD...
April 12, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28382804/optical-coherence-tomography-guided-therapy-of-instent-restenosis-for-peripheral-arterial-disease
#5
Michael K Lichtenberg, Jeffrey G Carr, Jaafer A Golzar
Approximately 27 million people in Europe and North America currently have peripheral arterial disease (PAD)1. The endovascular treatment of stenosis or blocked peripheral arteries in PAD include percutaneous transluminal angioplasty (PTA) with or without a drug coated balloon, atherectomy (rotational, directional, orbital or laser), and stenting. The development of next generation peripheral stents and drug coated stents have led to the improved treatment of complex SFA lesions, and consequently increased their usage23...
April 4, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28380412/%C3%AE-asarone-promotes-temozolomide-s-entry-into-glioma-cells-and-decreases-the-expression-of-p-glycoprotein-and-mdr1
#6
Nanbu Wang, Qinxin Zhang, Baile Ning, Laiyu Luo, Yongqi Fang
Glioma is the most common primary brain tumor and has an undesirable prognosis due to the blood-brain barrier (BBB) and drug resistance. A thorough investigation of the changes in intracellular drug concentrations is important to observe therapeutic effects and cell resistance. P-glycoprotein (P-gp) is an essential protein of Multi-drug resistance 1 (MDR1). The over-expression of P-gp and MDR1 is associated with poor prognosis and drug-resistance in glioma. However, β-asarone can pass through the BBB easily and increase the drug concentration in the rat brain...
April 2, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28379158/exome-sequencing-identified-a-novel-fbn2-mutation-in-a-chinese-family-with-congenital-contractural-arachnodactyly
#7
Guoling You, Bailing Zu, Bo Wang, Zhigang Wang, Yunlan Xu, Qihua Fu
Congenital contractural arachnodactyly (CCA) is an autosomal dominant disorder of connective tissue. CCA is characterized by arachnodactyly, camptodactyly, contrature of major joints, scoliosis, pectus deformities, and crumpled ears. The present study aimed to identify the genetic cause of a three-generation Chinese family with CCA. We successfully identified a novel missense mutation p.G1145D in the fibrillin-2 (FBN2) gene as the pathogenic mutation by whole exome sequencing (WES). The p.G1145D mutation occurs in the 12th calcium-binding epidermal growth factor-like (cbEGF) domain...
April 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28378366/effects-of-patient-centered-communication-on-anxiety-negative-affect-and-trust-in-the-physician-in-delivering-a-cancer-diagnosis-a-randomized-experimental-study
#8
Jelena Zwingmann, Walter F Baile, Johann W Schmier, Jürg Bernhard, Monika Keller
BACKGROUND: When bad news about a cancer diagnosis is being delivered, patient-centered communication (PCC) has been considered important for patients' adjustment and well-being. However, few studies have explored how interpersonal skills might help cancer patients cope with anxiety and distress during bad-news encounters. METHODS: A prospective, experimental design was used to investigate the impact of the physician communication style during a bad-news encounter...
April 5, 2017: Cancer
https://www.readbyqxmd.com/read/28377603/hmgb1-tlr4-il23-il17a-axis-promotes-paraquat-induced-acute-lung-injury-by-mediating-neutrophil-infiltration-in-mice
#9
Bailing Yan, Feng Chen, Lijun Xu, Jihong Xing, Xuefu Wang
Paraquat is a poisoning herbicide that primarily targets lung, leading to severe acute lung injury characterized by extensive neutrophil infiltration. However, the mechanisms underlying the neutrophil infiltration is not clear. In this study, we demonstrated the significance of the signaling cascade from high-mobility group box 1 (HMGB1), to Toll-like receptor 4 (TLR4), interleukin-23 (IL-23), and lastly to IL-17A during the paraquat-induced neutrophil infiltration and the subsequent lung injury in mice. Paraquat challenge significantly elevated serum levels of IL-17A and IL-23, the percentage of IL-17A-producing γδT cells in the lung, and the level of HMGB1 in bronchoalveolar lavage fluid...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28374492/in-vitro-laser-fenestration-of-aortic-stent-grafts-a-qualitative-analysis-under-scanning-electron-microscope
#10
Jing Lin, Naval Udgiri, Robert Guidoin, Jean Panneton, Xiaoning Guan, Maxime Guillemette, Lu Wang, Jia Du, Dajie Zhu, Mark Nutley, Ze Zhang
In situ fenestration of stent-grafts allows patients with life threatening aortic pathologies to be amenable to emergent "off the shelf indications for use" percutaneous treatments as a bail out technique. Three types of aortic stent-grafts were subjected to laser fenestration in a physiological saline solution followed by balloon angioplasty using 8, 10 or 12 mm in diameter noncompliant balloons. The morphology and the size of fenestrations were observed under optical and scanning electron microscopy. The damage to the fabrics was analyzed and quantified...
November 2016: Artificial Organs
https://www.readbyqxmd.com/read/28368961/colovesical-fistula-complicating-diverticular-disease-a-14-year-experience
#11
Bogdan Badic, Geoffroy Leroux, Jérémie Thereaux, Aurélien Joumond, Charles H Gancel, Jean P Bail, Guillaume Meurette
OBJECTIVE: Colovesical fistulas (CVF) constitute the most common type of spontaneously occurring fistulas associated with diverticular disease. One-stage laparoscopic resection has been shown to be feasible, but studies comparing this approach to open surgery are scarce. The aim of this study was to compare the clinical outcomes of open and laparoscopic surgery for CVF of diverticular origin. MATERIALS AND METHODS: From January 2000 to July 2014, 37 colectomies were performed for diverticular disease-related CVF...
April 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28359579/therapeutic-interventional-endoscopic-bail-out-in-life-threatening-surgical-complications
#12
EDITORIAL
Moishe Liberman
No abstract text is available yet for this article.
March 9, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28356719/synergistic-effects-of-antimicrobial-peptide-dp7-combined-with-antibiotics-against-multidrug-resistant-bacteria
#13
Xiaozhe Wu, Zhan Li, Xiaolu Li, Yaomei Tian, Yingzi Fan, Chaoheng Yu, Bailing Zhou, Yi Liu, Rong Xiang, Li Yang
Antibiotic-resistant bacteria present a great threat to public health. In this study, the synergistic effects of antimicrobial peptides (AMPs) and antibiotics on several multidrug-resistant bacterial strains were studied, and their synergistic effects on azithromycin (AZT)-resistance genes were analyzed to determine the relationships between antimicrobial resistance and these synergistic effects. A checkerboard method was used to evaluate the synergistic effects of AMPs (DP7 and CLS001) and several antibiotics (gentamicin, vancomycin [VAN], AZT, and amoxicillin) on clinical bacterial strains (Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, and Escherichia coli)...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28352476/cpap-treatment-adherence-in-women-with-obstructive-sleep-apnea
#14
E Libman, S Bailes, C S Fichten, D Rizzo, L Creti, M Baltzan, R Grad, A Pavilanis, D-L Tran, K Conrod, R Amsel
Untreated obstructive sleep apnea (OSA) has numerous negative health-related consequences. Continuous positive airway pressure (CPAP) is generally considered the treatment of choice for OSA, but rates of nonadherence are high. It is believed that OSA is more prevalent among men; therefore understanding how OSA presents among women is limited and treatment adherence has received little research attention. For this study, 29 women were recruited from primary care offices. They completed a questionnaire battery and underwent a night of nocturnal polysomnography (PSG) followed by a visit with a sleep specialist...
2017: Sleep Disorders
https://www.readbyqxmd.com/read/28350778/pediatric-rehabilitation-services-for-children-with-cerebral-palsy-what-can-existing-data-sources-tell-us
#15
Mary E Gannotti, Amy Bailes, Kristie Bjornson, Maggie OʼNeil, Marybeth Grant-Buettler, Stacey Dusing
Knowledge about associated service utilization patterns and positive outcomes in children with cerebral palsy (CP) of varying levels of severity is a national priority. Families, clinicians, program directors, and policy makers need this information for clinical decision-making and service planning. Existing data sources in the United States that contain information about children with CP, their health, function, well being, and utilization of health services may add to our existing knowledge. We provide a summary of fourteen national, state, and local sources' data: where the data come from, challenges and/or specific considerations when using or accessing information, and specific data elements included...
April 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28340412/discovery-of-2-substituted-1h-benzo-d-immidazole-4-carboxamide-derivatives-as-novel-poly-adp-ribose-polymerase-1-inhibitors-with-in%C3%A2-vivo-anti-tumor-activity
#16
Jie Zhou, Ming Ji, Zhixiang Zhu, Ran Cao, Xiaoguang Chen, Bailing Xu
Novel 1H-benzo[d]immidazole-4-carboxamide derivatives bearing five-membered or six-membered N-heterocyclic moieties at the 2-position were designed and synthesized as PARP-1 inhibitors. Structure-activity relationships were conducted and led to a number of potent PARP-1 inhibitors having IC50 values in the single or double digit nanomolar level. Some potent PARP-1 inhibitors also had similar inhibitory activities against PARP-2. Among all the synthesized compounds, compound 10a and 11e displayed strong potentiation effects on temozolomide (TMZ) in MX-1 cells (PF50 = 7...
March 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28334763/the-challenge-of-identifying-family-medicine-patients-with-obstructive-sleep-apnea-addressing-the-question-of-gender-inequality
#17
Sally Bailes, Catherine S Fichten, Dorrie Rizzo, Marc Baltzan, Roland Grad, Alan Pavilanis, Laura Creti, Rhonda Amsel, Eva Libman
Purpose.: The purpose of this study was to examine the sleep characteristics, metabolic syndrome disease and likelihood of obstructive sleep apnea in a sample of older, family medicine patients previously unsuspected for sleep apnea. Methods.: A total of 295 participants, minimum age 45, 58.7% women, were recruited from two family medicine clinics. None previously had been referred for sleep apnea testing. All participants completed a sleep symptom questionnaire and were offered an overnight polysomnography study, regardless of questionnaire results...
February 23, 2017: Family Practice
https://www.readbyqxmd.com/read/28325479/the-role-of-pancreatic-preproglucagon-in-glucose-homeostasis-in-mice
#18
Adam P Chambers, Joyce E Sorrell, April Haller, Karen Roelofs, Chelsea R Hutch, Ki-Suk Kim, Ruth Gutierrez-Aguilar, Bailing Li, Daniel J Drucker, David A D'Alessio, Randy J Seeley, Darleen A Sandoval
Glucagon-like peptide 1 (GLP-1) is necessary for normal gluco-regulation, and it has been widely presumed that this function reflects the actions of GLP-1 released from enteroendocrine L cells. To test the relative importance of intestinal versus pancreatic sources of GLP-1 for physiological regulation of glucose, we administered a GLP-1R antagonist, exendin-[9-39] (Ex9), to mice with tissue-specific reactivation of the preproglucagon gene (Gcg). Ex9 impaired glucose tolerance in wild-type mice but had no impact on Gcg-null or GLP-1R KO mice, suggesting that Ex9 is a true and specific GLP-1R antagonist...
April 4, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28302458/the-effects-of-dexmedetomidine-pretreatment-on-the-pro-and-anti-inflammation-systems-after-spinal-cord-injury-in-rats
#19
Hui Rong, Zhibin Zhao, Jiying Feng, Yishan Lei, Hao Wu, Rao Sun, Zuoxia Zhang, Bailing Hou, Wei Zhang, YuE Sun, Xiaoping Gu, Zhengliang Ma, Yue Liu
Excessive inflammatory responses play important roles in the aggravation of secondary damage to an injured spinal cord. Dexmedetomidine (DEX), a selective α2-adrenoceptor agonist, has recently been implied to be neuroprotective in clinical anesthesia, but the underlying mechanism is elusive. As signaling through Toll-like receptor 4 (TLR4) and nicotinic receptors (nAChRs, notably α7nAChR) play important roles in the pro- and anti-inflammation systems in the central nervous system, respectively, this study investigated whether and how they were modulated by DEX pretreatment in a rat model of spinal cord compression...
March 14, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28302281/the-art-and-science-of-pediatric-damage-control
#20
REVIEW
Anthony Tran, Brendan T Campbell
Damage control is a surgical strategy that has evolved and expanded considerably over the past 25 years. The approach was initially developed as a "bail out" procedure to control bleeding with severe abdominal injuries in the setting of unmitigated hemorrhagic shock. Damage control is now more broadly applied as a comprehensive management plan for the resuscitation and surgical treatment of injured patients with exhausted physiologic and metabolic reserve. This article reviews the most current concepts in damage control that are important and relevant to the practicing pediatric surgeon...
February 2017: Seminars in Pediatric Surgery
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