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https://www.readbyqxmd.com/read/28829816/matriptase-shedding-is-closely-coupled-with-matriptase-zymogen-activation-and-requires-de-novo-proteolytic-cleavage-likely-involving-its-own-activity
#1
Chun-Che Tseng, Bailing Jia, Robert Barndt, Yayun Gu, Chien-Yu Chen, I-Chu Tseng, Sheng-Fang Su, Jehng-Kang Wang, Michael D Johnson, Chen-Yong Lin
The type 2 transmembrane serine protease matriptase is involved in many pathophysiological processes probably via its enzymatic activity, which depends on the dynamic relationship between zymogen activation and protease inhibition. Matriptase shedding can prolong the life of enzymatically active matriptase and increase accessibility to substrates. We show here that matriptase shedding occurs via a de novo proteolytic cleavage at sites located between the SEA domain and the CUB domain. Point or combined mutations at the four positively charged amino acid residues in the region following the SEA domain allowed Arg-186 to be identified as the primary cleavage site responsible for matriptase shedding...
2017: PloS One
https://www.readbyqxmd.com/read/28821710/green-br%C3%A3-nsted-acid-ionic-liquids-as-novel-corrosion-inhibitors-for-carbon-steel-in-acidic-medium
#2
Shuyun Cao, Dan Liu, Peng Zhang, Lixia Yang, Peng Yang, Hui Lu, Jianzhou Gui
New ionic liquids with multiple Brönsted acid sites were synthesized in ≥98% yield, and their inhibiting properties for the corrosion of carbon steel in 0.5 M HCl solution had been evaluated using electrochemical impedance spectroscopy, potentiodynamic polarization and weight loss method, finally the possible inhibiting mechanism was proposed according to UV-visible spectroscopic measurements and surface analysis including SEM and XPS techniques. The designed cation structure of Brönsted acid ionic liquids (BAILs), with one phenyl and two imidazolium rings, makes them good mixed-type inhibitors via the adsorption of BAILs on the steel surface to suppress both anodic and cathodic processes, obeying Langmuir adsorption isotherm...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28817579/the-link-between-bond-forfeiture-and-pretrial-release-mechanism-the-case-of-dallas-county-texas
#3
Stephen J Clipper, Robert G Morris, Amanda Russell-Kaplan
PURPOSE: The goal of this study was to evaluate the efficacy of four pretrial jail release mechanisms (i.e., bond types) commonly used during the pretrial phase of the criminal justice process in terms of their ability to discriminate between defendants failing to appear in court (i.e., bond forfeiture). These include attorney bonds, cash bonds, commercial bail bonds, and release via a pretrial services agency. METHODS: A multi-treatment propensity score matching protocol was employed to assess between-release-mechanism differences in the conditional probability of failure to appear/bond forfeiture...
2017: PloS One
https://www.readbyqxmd.com/read/28776671/%C3%AE-asarone-inhibited-cell-growth-and-promoted-autophagy-via-p53-bcl-2-bclin-1-and-p53-ampk-mtor-pathways-in-human-glioma-u251-cells
#4
Nanbu Wang, Qinxin Zhang, Laiyu Luo, Baile Ning, Yongqi Fang
Glioma is the most common type of primary brain tumor and has an undesirable prognosis. Autophagy plays an important role in cancer therapy, but it's effect is still not definite. P53 is an important tumor suppressor gene and protein that is closely to autophagy. Our aim was to study the effect of β-asarone on inhibiting cell proliferation in human glioma U251 cells and to detect the effect of the inhibition on autophagy through the P53 signal pathway. For cell growth, the cells were divided into four groups: the model, β-asarone, temozolomide (TMZ) and co-administration groups...
August 4, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28763051/the-ancestral-flower-of-angiosperms-and-its-early-diversification
#5
Hervé Sauquet, Maria von Balthazar, Susana Magallón, James A Doyle, Peter K Endress, Emily J Bailes, Erica Barroso de Morais, Kester Bull-Hereñu, Laetitia Carrive, Marion Chartier, Guillaume Chomicki, Mario Coiro, Raphaël Cornette, Juliana H L El Ottra, Cyril Epicoco, Charles S P Foster, Florian Jabbour, Agathe Haevermans, Thomas Haevermans, Rebeca Hernández, Stefan A Little, Stefan Löfstrand, Javier A Luna, Julien Massoni, Sophie Nadot, Susanne Pamperl, Charlotte Prieu, Elisabeth Reyes, Patrícia Dos Santos, Kristel M Schoonderwoerd, Susanne Sontag, Anaëlle Soulebeau, Yannick Staedler, Georg F Tschan, Amy Wing-Sze Leung, Jürg Schönenberger
Recent advances in molecular phylogenetics and a series of important palaeobotanical discoveries have revolutionized our understanding of angiosperm diversification. Yet, the origin and early evolution of their most characteristic feature, the flower, remains poorly understood. In particular, the structure of the ancestral flower of all living angiosperms is still uncertain. Here we report model-based reconstructions for ancestral flowers at the deepest nodes in the phylogeny of angiosperms, using the largest data set of floral traits ever assembled...
August 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/28754414/control-oriented-modeling-and-adaptive-backstepping-control-for-a-nonminimum-phase-hypersonic-vehicle
#6
Linqi Ye, Qun Zong, Bailing Tian, Xiuyun Zhang, Fang Wang
In this paper, the nonminimum phase problem of a flexible hypersonic vehicle is investigated. The main challenge of nonminimum phase is the prevention of dynamic inversion methods to nonlinear control design. To solve this problem, we make research on the relationship between nonminimum phase and backstepping control, finding that a stable nonlinear controller can be obtained by changing the control loop on the basis of backstepping control. By extending the control loop to cover the internal dynamics in it, the internal states are directly controlled by the inputs and simultaneously serve as virtual control for the external states, making it possible to guarantee output tracking as well as internal stability...
July 25, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28752524/serial-combination-of-non-invasive-tools-improves-the-diagnostic-accuracy-of-severe-liver-fibrosis-in-patients-with-nafld
#7
S Petta, V W-S Wong, C Cammà, J-B Hiriart, G L-H Wong, J Vergniol, A W-H Chan, V Di Marco, W Merrouche, H L-Y Chan, F Marra, B Le-Bail, U Arena, A Craxì, V de Ledinghen
BACKGROUND: The accuracy of available non-invasive tools for staging severe fibrosis in patients with nonalcoholic fatty liver disease (NAFLD) is still limited. AIM: To assess the diagnostic performance of paired or serial combination of non-invasive tools in NAFLD patients. METHODS: We analysed data from 741 patients with a histological diagnosis of NAFLD. The GGT/PLT, APRI, AST/ALT, BARD, FIB-4, and NAFLD Fibrosis Score (NFS) scores were calculated according to published algorithms...
July 27, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28743904/dietary-acrylamide-exposure-was-associated-with-mild-cognition-decline-among-non-smoking-chinese-elderly-men
#8
Zhao-Min Liu, Lap Ah Tse, Bailing Chen, Suyang Wu, Dicken Chan, Timothy Kowk, Jean Woo, Yu-Tao Xiang, Samuel Yeung-Shan Wong
The aim of the study is to explore the longitudinal association of dietary acrylamide exposure with cognitive performance in Chinese elderly. The analysis was conducted among 2534 non-smoking elderly men and women based on a prospective study, Mr. and Ms. OS Hong Kong. Dietary acrylamide intake was assessed by food frequency questionnaires with data on local food contamination, derived from the first Hong Kong Total Diet Study. Global cognitive function was assessed by Cantonese version of Mini-Mental State Exam (MMSE) at the baseline and the 4(th) year of follow-up...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28738885/differential-effects-of-fty720-on-the-b-cell-compartment-in-a-mouse-model-of-multiple-sclerosis
#9
Kathrin Bail, Quirin Notz, Damiano M Rovituso, Andrea Schampel, Marie Wunsch, Tobias Koeniger, Verena Schropp, Richa Bharti, Claus-Juergen Scholz, Konrad U Foerstner, Christoph Kleinschnitz, Stefanie Kuerten
BACKGROUND: MP4-induced experimental autoimmune encephalomyelitis (EAE) is a mouse model of multiple sclerosis (MS), which enables targeted research on B cells, currently much discussed protagonists in MS pathogenesis. Here, we used this model to study the impact of the S1P1 receptor modulator FTY720 (fingolimod) on the autoreactive B cell and antibody response both in the periphery and the central nervous system (CNS). METHODS: MP4-immunized mice were treated orally with FTY720 for 30 days at the peak of disease or 50 days after EAE onset...
July 24, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28726047/dietary-acrylamide-exposure-was-associated-with-increased-cancer-mortality-in-chinese-elderly-men-and-women-a-11-year-prospective-study-of-mr-and-ms-os-hong-kong
#10
Zhao-Min Liu, Lap Ah Tse, Suzanne C Ho, Suyang Wu, Bailing Chen, Dicken Chan, Samuel Yeung-Shan Wong
AIM: Our study aims to investigate the association between dietary acrylamide exposure and cancer mortality among Chinese elderly. METHODS: A prospective cohort of 4000 elderly men and women aged 65 years and above (Mr. and Ms. OS Hong Kong study) was recruited from local communities from 2001 to 2003. Dietary exposure to acrylamide was evaluated at baseline based on a validated food frequency questionnaire and an acrylamide database from the 1st Hong Kong Total Diet Study...
July 19, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28710035/association-of-common-genetic-variants-in-vegfa-with-biliary-atresia-susceptibility-in-northwestern-han-chinese
#11
Bailing Liu, Jingli Wei, Miao Li, Jue Jiang, Hui Zhang, Li Yang, Haibin Wu, Qi Zhou
Biliary atresia (BA) is a major neonatal obliterative cholangiopathy, resulting in progressive cirrhosis. The gene VEGFA encodes a heparin-binding protein that is a regulator of angiogenesis and a mediator of inflammatory reactions, and accumulating evidence have indicated that VEGFA may play a possible role in the pathogenesis of BA. Our study aim was to evaluate the association of common variants within the VEGFA gene with BA susceptibility in Northwestern Han Chinese population. Forty tag SNPs within the VEGFA gene were selected in the study, and then subsequently genotyped in 1336 Northwestern Han Chinese individuals, consisting of 311 BA patients and 1025 healthy controls...
July 11, 2017: Gene
https://www.readbyqxmd.com/read/28692592/reduction-in-temporary-and-permanent-audiological-injury-through-internal-jugular-vein-compression-in-a-rodent-blast-injury-model
#12
Brian Sindelar, Michael Shinners, Sydney Sherman, Kristine Erickson, Vimal Patel, Paul Kubilis, John D Finan, Julian E Bailes
HYPOTHESIS: Internal jugular vein (IJV) compression influences not only intracranial but also intracochlear physiology and has demonstrated preclinical effectiveness in reducing acute audiological injury in a rodent blast model. However, the long-term effects in this model are unknown. BACKGROUND: Blast wave-induced audiological injury from an improvised explosive device is a leading cause of morbidity among service members in theater but there are limitations to the current protective measures...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28692443/a-single-test-combining-blood-markers-and-elastography-is-more-accurate-than-other-fibrosis-tests-in-the-main-causes-of-chronic-liver-diseases
#13
Alexandra Ducancelle, Vincent Leroy, Julien Vergniol, Nathalie Sturm, Brigitte Le Bail, Jean Pierre Zarski, Eric Nguyen Khac, Dominique Salmon, Victor de Ledinghen, Paul Calès
BACKGROUND AND GOAL: International guidelines suggest combining a blood test and liver stiffness measurement (LSM) to stage liver fibrosis in chronic hepatitis C (CHC) and non-alcoholic fatty liver disease (NAFLD). Therefore, we compared the accuracies of these tests between the main etiologies of chronic liver diseases. STUDY: Overall, 1968 patients were included in 5 etiologies: CHC: 698, chronic hepatitis B: 152, human immunodeficiency virus/CHC: 628, NAFLD: 225, and alcoholic liver disease (ALD): 265...
August 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28673409/neurosurgical-emergencies-in-sport
#14
REVIEW
Brian Sindelar, Julian E Bailes
Sports related severe brain and spinal cord injuries are medical and potentially surgical emergencies that require timely intervention in order to reduce worsening secondary injury. For this reason, it is important for all medical professionals managing athletic injuries to be knowledgeable in the clinical approach to this type of acute event. This article reviews the initial evaluation of the athlete that occurs on the field and also within the emergency department with a focus on presenting clinical signs of a neurosurgical emergency...
August 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/28657488/the-risks-associated-with-the-use-of-lamotrigine-during-pregnancy
#15
Lingli Kong, Tiantian Zhou, Bailing Wang, Zhenbo Gao, Chunxia Wang
OBJECTIVE: This paper reviewed the relevant literature on the effects of lamotrigine on pregnancy outcomes to provide useful information regarding lamotrigine use in pregnant women with bipolar disorder. METHODS: A systematic search of electronic databases and other original sources was conducted that examined the effects of lamotrigine on pregnancy outcomes. RESULTS: It is not clear that foetuses of lamotrigine-exposed pregnant women are at higher risk of malformation or neurodevelopmental delay...
June 28, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28652089/in-vivo-confocal-laser-endomicroscopy-during-laparoscopy-for-gynecological-surgery-a-promising-tool
#16
G Chene, L Chauvy, A Buenerd, S Moret, B Nadaud, E Beaufils, K Le Bail-Carval, P Chabert, G Mellier, G Lamblin
INTRODUCTION: To investigate the technical feasibility of optical biopsy (probe-based confocal laser endomicroscopy [pCLE]) during laparoscopy and by the vaginal route in the exploration of pelvic gynecological cancers. METHODS: Prospective study including 31 patients undergoing laparoscopic hysterectomy (benign or malignant indication). Confocal microlaparoscopy (analysis of tubes, ovaries, and depending on the type de cancer, pelvic adenopathies) and optical biopsy of the endometrium were first carried out by the vaginal route under general anesthesia...
June 23, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28646562/argininosuccinate-synthase-1-ass1-a-marker-of-unclassified-hepatocellular-adenoma-and-high-bleeding-risk
#17
Elodie Henriet, Aya Abou Hammoud, Jean-William Dupuy, Benjamin Dartigues, Zakaria Ezzoukry, Nathalie Dugot-Senant, Thierry Leste-Lasserre, Nestor Pallares-Lupon, Macha Nikolski, Brigitte Le Bail, Jean-Frédéric Blanc, Charles Balabaud, Paulette Bioulac-Sage, Anne-Aurélie Raymond, Frédéric Saltel
Hepatocellular adenomas (HCA) are rare benign tumors divided into three main subgroups defined by patho-molecular features, HNF1A (H-HCA), mutated β-catenin (b-HCA) and inflammatory (IHCA). In the case of unclassified HCA (UHCA), which are currently identified by default, a high risk of bleeding remains a clinical issue. The objective of this study was to explore UHCA proteome with the aim to identify specific biomarkers. Following dissection of the tumoral (T) and non-tumoral (NT) tissue on formalin-fixed paraffin-embedded (FFPE) from HCA tissue sections using laser capture methodology, we performed mass spectrometry analysis to compare T and NT protein expression levels in HCA, H-HCA, IHCA, b-HCA, UHCA and focal nodular hyperplasia...
June 23, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28641228/relationships-between-past-and-present-pesticide-applications-and-pollution-at-a-watershed-outlet-the-case-of-a-horticultural-catchment-in-martinique-french-west-indies
#18
Charles Mottes, Magalie Lesueur Jannoyer, Marianne Le Bail, Mathilde Guéné, Céline Carles, Eric Malézieux
The understanding of factors affecting pesticide transfers to catchment outlet is still at a very early stage in tropical context, and especially on tropical volcanic context. We performed on-farm pesticide use surveys during 87 weeks and monitored pesticides in water weekly during 67 weeks at the outlet of a small catchment in Martinique. We identified three types of pollution. First, we showed long-term chronic pollution by chlordecone, diuron and metolachlor resulting from horticultural practices applied 5-20 years ago (quantification frequency higher than 80%)...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28632690/noninvasive-nuclear-spect-myocardial-blood-flow-quantitation-to-guide-management-for-coronary-artery-disease
#19
Lung-Ching Chen, Bor-Hsin Jong, Sheng-Che Lin, Chi-Tai Ku, Ing-Jou Chen, Yen-Kung Chen, Bailing Hsu
Recently, myocardial blood flow quantitation with dynamic SPECT has been validated to enhance the detection of multivessel coronary artery disease (CAD) and conclude equivocal SPECT myocardial perfusion study. This advance opened an important clinical application to utilize the tool in guiding CAD management for area where myocardial perfusion tracers for PET are unavailable or unaffordable. We present a clinical patient with ongoing recursive angina who underwent multiple nuclear stress tests for a sequence of CAD evaluation in 26 months and demonstrated that SPECT myocardial blood flow quantitation properly guided CAD management to warrant patient outcome...
September 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28625964/antegrade-dissection-and-reentry-as-part-of-the-hybrid-chronic-total-occlusion-revascularization-strategy-a-subanalysis-of-the-recharge-registry-registry-of-crossboss-and-hybrid-procedures-in-france-the-netherlands-belgium-and-united-kingdom
#20
Joren Maeremans, Jo Dens, James C Spratt, Alan J Bagnall, Wynand Stuijfzand, Alexander Nap, Pierfrancesco Agostoni, William Wilson, Colm G Hanratty, Simon Wilson, Benjamin Faurie, Alexandre Avran, Erwan Bressollette, Mohaned Egred, Paul Knaapen, Simon Walsh
BACKGROUND: Development of the CrossBoss and Stingray devices for antegrade dissection and reentry (ADR) of chronic total occlusions has improved historically suboptimal outcomes. However, the outcomes, safety, and failure modes of the technique have to be studied in a larger patient cohort. This preplanned substudy of the RECHARGE registry (Registry of CrossBoss and Hybrid Procedures in France, the Netherlands, Belgium and United Kingdom) aims to evaluate the value and use of ADR and determine its future position in contemporary chronic total occlusion intervention...
June 2017: Circulation. Cardiovascular Interventions
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