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https://www.readbyqxmd.com/read/28102464/a-phase-i-and-pharmacokinetic-study-of-afilbercept-with-folfiri-comparison-of-chinese-and-caucasian-populations
#1
Jianming Xu, Yingxin Li, Xing Sun, Dongsheng Zhang, Rongrui Liu, Samira Ziti-Ljajic, Dongmei Shi, Fengying Xue, Nathalie Le Bail, Ruihua Xu
Background This study assessed the preliminary safety, pharmacokinetics (PK) and anti-tumor effects of aflibercept in combination with 5-fluorouracil, leucovorin and irinotecan (FOLFIRI) in Chinese patients with previously-treated advanced solid malignancies. Patients and Methods This open-label single-arm Phase I study conducted at two centers in China included adult (≥18 years) patients with metastatic or unresectable solid malignancies who had received ≥1 prior treatment. Patients received aflibercept 4 mg/kg IV on Day 1 followed by FOLFIRI over Days 1 and 2 every 2 weeks, and were assessed for safety, tumor response, PK parameters and immunogenicity...
January 19, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28090010/long-term-outcomes-after-percutaneous-lower-extremity-arterial-interventions-with-atherectomy-vs-balloon-angioplasty%C3%A3-propensity-score-matched-registry
#2
Adam Janas, Piotr P Buszman, Krzysztof P Milewski, Szymon Wiernek, Ksenia Janas, Maciej Pruski, Wojciech Wojakowski, Aleksandra Błachut, Wojciech Picheta, Pawel Buszman, Stefan Kiesz
BACKGROUND: The impact of endovascular revascularization of the lower extremity arteries with atherectomy (AT) compared with percutaneous transluminal angioplasty (PTA) is still unclear. Therefore, the aim of the study was to compare long-term outcomes after percutaneous PTA and AT in patients requiring endovascular revascularization.Methods and Results:This was a single-center, retrospective registry of obstructive and symptomatic PAD patients who underwent endovascular revascularization...
January 14, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28087551/cost-effectiveness-of-superficial-femoral-artery-endovascular-interventions-in-the-uk-and-germany-a-modelling-study
#3
Benjamin C Kearns, Steven M Thomas
OBJECTIVES: To assess the lifetime costs and cost-effectiveness of 5 endovascular interventions to treat superficial femoral arterial disease. DESIGN: A model-based health economic evaluation. An existing decision analytical model was used, with updated effectiveness data taken from the literature, and updated costs based on purchasing prices. SETTING: UK and German healthcare perspectives were considered. PARTICIPANTS: Patients with intermittent claudication of the femoropopliteal arteries eligible for endovascular treatment...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28079681/internal-jugular-vein-compression-a-novel-approach-to-mitigate-blast-induced-hearing-injury
#4
Brian Sindelar, Michael Shinners, Sydney Sherman, Kevin Novak, Kristine Erickson, Vimal Patel, Paul Kubilis, David Smith, John Finan, Julian E Bailes
HYPOTHESIS: Internal jugular vein (IJV) compression before blast injury will lead to reduced risk of traumatic hearing injury following exposure to a blast injury. BACKGROUND: IJV compression and its effects on not only intracranial, but also intracochlear pressure may potentiate blast induced hearing injury, therefore, precluding its use as a prophylactic therapy for blast induced traumatic brain injury. METHODS: Twenty Sprague Dawley rats were exposed to a 17...
January 10, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28070676/-upper-extremity-fractures-in-the-elderly
#5
Roland Biber, S Grüninger, H J Bail
Upper extremity fractures in the elderly are very frequent and second only to hip fractures in the group of fragility fractures. Their impact on mobility and functional decline seems to be underestimated especially when they occur in combination with lower extremity fractures. Fractures of the proximal humerus and the distal radius can often be treated conservatively; however, the indications for operative treatment must not be based on fracture morphology alone and due consideration should be given to all concomitant circumstances affecting functional aspects of patients...
January 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28040080/is-it-safe-to-assist-proximal-humeral-nailing-to-residents-an-analysis-of-1134-cases
#6
Burak Altintas, Roland Biber, Hermann J Bail
INTRODUCTION: Intramedullary nailing is a common procedure for the treatment of proximal humeral fractures. In practical resident training this standardized operation plays an important role in the introduction to osteosynthesis. Our aim was to investigate whether assisting this operation to residents influences the surgical complication rate both in-house and on re-admission. METHODS: All 1134 patients who received a proximal humeral Targon PH nail (Aesculap) for proximal humeral fractures were included between 2000 and 2013...
December 2016: Injury
https://www.readbyqxmd.com/read/28040074/the-art-of-trochanteric-fracture-reduction
#7
Roland Biber, Johanna Berger, Hermann Josef Bail
The name of Ender is primarily associated with the Ender nails, which were popular for trochanteric fracture fixation more than thirty years ago. However, Ender's concepts were not limited to the implant. Ender developed a unique classification system for trochanteric and subtrochanteric fractures, which provided the theory for closed reduction maneuvers that made the method so successful in his hands. While Ender's nails have become history in the meantime, his principles of fracture reduction can be readily applied on surgery with modern implants such as proximal femoral nails...
December 2016: Injury
https://www.readbyqxmd.com/read/28040070/humeral-head-necrosis-after-proximal-humeral-nailing-what-are-the-reasons-for-bad-outcomes
#8
Birgit Zirngibl, Roland Biber, Hermann Josef Bail
INTRODUCTION: Humeral head necrosis (HHN) remains a major problem in fracture care. Neither its occurrence, its extend, nor its impact on clinical outcomes is predictable on the long term. This study was designed to evaluate clinical and radiological outcomes in patients depending on the influence of HHN. PATIENTS AND METHODS: 32 patients with a 3-6 year follow up participated in this study. Their humeral fractures had been stabilized with a standard Targon PH nail (Aesculap, Tuttlingen, Germany) for an acute humeral head fracture...
December 2016: Injury
https://www.readbyqxmd.com/read/28032260/engaging-an-urban-african-american-community-to-deliver-cognitive-health-education-to-breast-cancer-survivors
#9
Jennifer Bail, Timiya S Nolan, Jacqueline B Vo, Silvia Gisiger-Camata, Karen Meneses
Little is known about cognitive changes among African American (AA) breast cancer survivors (BCS). Here, we report our experience with engagement of leaders of urban AA churches in Birmingham, Alabama to deliver and evaluate Think Well: Healthy Living to Improve Cognitive Function, an educational cognitive health program for BCS. The Think Well team engaged leaders of urban AA churches using a 7-step process: 1) identify leaders, 2) develop connection with leaders, 3) assess AA community preferences, 4) tailor for cultural relevance, 5) plan seminars, 6) deliver seminars, and 7) evaluate cultural relevance and overall program quality...
December 28, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28027468/a-strategy-to-achieve-efficient-dual-mode-luminescence-in-lanthanide-based-magnetic-hybrid-nanostructure-and-its-demonstration-for-the-detection-of-latent-fingerprints
#10
Praveen K Shahi, Priyam Singh, Akhilesh K Singh, Sunil K Singh, Shyam B Rai, Rajiv Prakash
We have synthesized a novel inorganic-organic hybrid nanostructure (IOHN) composed of fluoride nanophosphor (NaGd0.78Er0.02Yb0.2F4) and β-diketones complex (Eu(DBM)3Phen). The Le Bail fitting of X-ray diffraction data suggests that the nanophoshor crystallizes in a hexagonal structure (P63/m space group). The TEM studies reveal that the nanophosphor and the IOHN both have average particle size of 6-8nm. The Eu(DBM)3Phen and NaGd0.78Er0.02Yb0.2F4 show characteristic down-shifting (DS) and up-conversion (UC) emission, under UV and NIR excitation, respectively...
December 19, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28026000/low-magnitude-high-frequency-vibration-promotes-the-adhesion-and-the-osteogenic-differentiation-of-bone-marrow-derived-mesenchymal-stem-cells-cultured-on-a-hydroxyapatite-coated-surface-the-direct-role-of-wnt-%C3%AE-catenin-signaling-pathway-activation
#11
Bailing Chen, Tao Lin, Xiaoxi Yang, Yiqiang Li, Denghui Xie, Wenhui Zheng, Haowen Cui, Weimin Deng, Xin Tan
The positive effect of low-magnitude, high‑frequency (LMHF) vibration on implant osseointegration has been demonstrated; however, the underlying cellular and molecular mechanisms remain unknown. The aim of this study was to explore the effect of LMHF vibration on the adhesion and the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) cultured on hydroxyapatite (HA)-coated surfaces in an in vitro model as well as to elucidate the molecular mechanism responsible for the effects of LMHF vibration on osteogenesis...
November 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27939373/molecular-classification-of-hepatocellular-adenoma-associates-with-risk-factors-bleeding-and-malignant-transformation
#12
Jean Charles Nault, Gabrielle Couchy, Charles Balabaud, Guillaume Morcrette, Stefano Caruso, Jean-Frederic Blanc, Yannick Bacq, Julien Calderaro, Valérie Paradis, Jeanne Ramos, Jean-Yves Scoazec, Viviane Gnemmi, Nathalie Sturm, Catherine Guettier, Monique Fabre, Eric Savier, Laurence Chiche, Philippe Labrune, Janick Selves, Dominique Wendum, Camilla Pilati, Alexis Laurent, Anne De Muret, Brigitte Le Bail, Sandra Rebouissou, Sandrine Imbeaud, Paulette Bioulac-Sage, Eric Letouzé, Jessica Zucman-Rossi
BACKGROUND & AIMS: Hepatocellular adenomas (HCA) are benign liver tumors that can be assigned to molecular subtypes based on inactivating mutations in HNF1A, activating mutations in β-catenin, or activation of inflammatory signaling pathways. We aimed to update the classification system for HCA and associate the subtypes with disease risk factors and complications. METHODS: We analyzed expression levels of 20 genes and sequenced exon regions of 8 genes (HNF1A, IL6ST, CTNNB1, FRK, STAT3, GNAS, JAK1, and TERT) in 607 samples of 533 HCAs from 411 patients, collected from 28 centers mainly in France from 2000 and 2014...
December 7, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27932851/computational-fluid-dynamic-modeling-of-a-medium-sized-surface-mine-blasthole-drill-shroud
#13
Y Zheng, W R Reed, L Zhou, J P Rider
The Pittsburgh Mining Research Division of the U.S. National Institute for Occupational Safety and Health (NIOSH) recently developed a series of models using computational fluid dynamics (CFD) to study airflows and respirable dust distribution associated with a medium-sized surface blasthole drill shroud with a dry dust collector system. Previously run experiments conducted in NIOSH's full-scale drill shroud laboratory were used to validate the models. The setup values in the CFD models were calculated from experimental data obtained from the drill shroud laboratory and measurements of test material particle size...
November 2016: Mining Engineering
https://www.readbyqxmd.com/read/27925726/acoustic-type-ii-weyl-nodes-from-stacking-dimerized-chains
#14
Zhaoju Yang, Baile Zhang
Lorentz-violating type-II Weyl fermions, which were missed in Weyl's prediction of nowadays classified type-I Weyl fermions in quantum field theory, have recently been proposed in condensed matter systems. The semimetals hosting type-II Weyl fermions offer a rare platform for realizing many exotic physical phenomena that are different from type-I Weyl systems. Here we construct the acoustic version of a type-II Weyl Hamiltonian by stacking one-dimensional dimerized chains of acoustic resonators. This acoustic type-II Weyl system exhibits distinct features in a finite density of states and unique transport properties of Fermi-arc-like surface states...
November 25, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27890554/endocarditis-after-interventional-repair-of-the-mitral-valve-review-of-a-dilemma
#15
REVIEW
Niklas F Boeder, Oliver Dörr, Johannes Rixe, Kay Weipert, Timm Bauer, Matthias Bayer, Christian W Hamm, Holger M Nef
BACKGROUND: The MitraClip procedure can be an alternative treatment option for patients with high surgical risk for whom surgical treatment is contraindicated. Patients with prosthetic material have an increased risk for infective endocarditis. HYPOTHESIS: Incidence, treatment and outcome of patients with endocarditis after interventional mitral valve repair are not known. METHODS: We searched for articles using PubMed using the terms "interventional mitral valve repair", "mitraclip" and "endocarditis"...
November 10, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/27878172/understanding-the-role-of-hydrogen-bonding-in-br%C3%A3-nsted-acidic-ionic-liquid-catalyzed-transesterification-a-combined-theoretical-and-experimental-investigation
#16
Kaixin Li, Yibo Yan, Jun Zhao, Junxi Lei, Xinli Jia, Samir H Mushrif, Yanhui Yang
Brønsted acidic ionic liquids (BAILs) can play a dual role, as a solvent and as a catalyst, in many reactions. However, molecular details of the catalytic mechanism are poorly understood. We present here a density functional theory (DFT) study for the catalytic mechanism of the transesterification of methyl ester (ME) with trimethylolpropane (TMP), in the presence of three representative BAILs, namely, N-methylimidazole-IL, pyridinium-IL, and triethylamine-IL. The deprotonation of the BAIL cation and the transesterification step are investigated...
December 7, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27875729/-seesaw-balloon-wire-cutting-technique-is-superior-to-tornus-catheter-in-balloon-uncrossable-chronic-total-occlusions
#17
Jingyi Xue, Jianqiang Li, Hongjun Wang, Li Sheng, Yongtai Gong, Danghui Sun, Shuang Li, Weimin Li, Dingyu Wang, Yue Li
BACKGROUND: Inability to advance a balloon is a well-recognized cause leading to a failure in recanalization of chronic total occlusions (CTOs) despite successfully passing a guidewire. A few techniques and devices have been introduced to facilitate balloon passage, especially the use of Tornus catheter. However, complex manipulation, expensive cost, and availability limit the application of these methods. This study was to evaluate the efficiency and safety of "seesaw balloon-wire cutting" technique in comparison with Tornus catheter for balloon uncrossable CTOs...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27866138/coronary-covered-stents
#18
Ismail Dogu Kilic, Enrico Fabris, Roberta Serdoz, Gianluca Caiazzo, Nicolas Foin, Sara Abou-Sherif, Carlo Di Mario
Covered stents offer an effective bail-out strategy in vessel perforations, are an alternative to surgery for the exclusion of coronary aneurysms, and have a potential role in the treatment of friable embolisation-prone plaques. The aim of this manuscript is to offer an overview of currently available platforms and to report results obtained in prior studies.
November 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27856844/the-magnetic-field-and-turbulence-of-the-cosmic-web-measured-using-a-brilliant-fast-radio-burst
#19
V Ravi, R M Shannon, M Bailes, K Bannister, S Bhandari, N D R Bhat, S Burke-Spolaor, M Caleb, C Flynn, A Jameson, S Johnston, E F Keane, M Kerr, C Tiburzi, A V Tuntsov, H K Vedantham
Fast radio bursts (FRBs) are millisecond-duration events thought to originate beyond the Milky Way galaxy. Uncertainty surrounding the burst sources, and their propagation through intervening plasma, has limited their use as cosmological probes. We report on a mildly dispersed (dispersion measure 266.5 ± 0.1 parsecs per cubic centimeter), exceptionally intense (120 ± 30 janskys), linearly polarized, scintillating burst (FRB 150807) that we directly localize to 9 square arc minutes. On the basis of a low Faraday rotation (12...
December 9, 2016: Science
https://www.readbyqxmd.com/read/27847818/aqueous-leaf-extract-of-jatropha-mollissima-pohl-bail-decreases-local-effects-induced-by-bothropic-venom
#20
Jacyra Antunes Dos Santos Gomes, Juliana Félix-Silva, Júlia Morais Fernandes, Juliano Geraldo Amaral, Norberto Peporine Lopes, Eryvaldo Sócrates Tabosa do Egito, Arnóbio Antônio da Silva-Júnior, Silvana Maria Zucolotto, Matheus de Freitas Fernandes-Pedrosa
Snakebites are a serious worldwide public health problem. In Brazil, about 90% of accidents are attributed to snakes from the Bothrops genus. The specific treatment consists of antivenom serum therapy, which has some limitations such as inability to neutralize local effects, difficult access in some regions, risk of immunological reactions, and high cost. Thus, the search for alternative therapies to treat snakebites is relevant. Jatropha mollissima (Euphorbiaceae) is a medicinal plant popularly used in folk medicine as an antiophidic remedy...
2016: BioMed Research International
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