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https://www.readbyqxmd.com/read/29427749/long-term-functional-and-oncological-results-after-sphincter-saving-resection-for-rectal-cancer-cohort-study
#1
Bogdan Badic, Aurélien Joumond, Jérémie Thereaux, Charles Henry Gancel, Jean Pierre Bail
PURPOSE: The treatment of rectal cancer could be complex and the long term complications have the potential to greatly impact the quality of life. The aim of this study was to evaluate the long term functional and oncological results after sphincter-saving resection for rectal cancer. METHODS: Between January 2005 and December 2013, a total of 187 rectal resections with total mesorectal excision (TME) for cancer were performed. The data of 72 (38.5%) patients were available for analysis...
February 7, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29413185/editorial-commentary-anchors-away-reflections-on-anchor-placement-and-number-in-rotator-cuff-repair
#2
EDITORIAL
Alan S Curtis
The ideal construct for a rotator cuff repair continues to be a hot topic for debate and biomechanical investigation. A recent study shows that anchors could be placed as close as 1 mm apart without impact on pullout strength. However, further overlap (the buddy anchor construct) led to earlier failure. This conclusion differs from other studies that have recommended the "buddy anchor" construct as a bail-out option in osteoporotic bone. Biomechanical studies are an important source of information for surgical decision making, but often do not directly predict the in vivo environment...
February 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29409363/comparison-of-clinical-outcomes-among-dual-ovarian-stimulation-mild-stimulation-and-luteal-phase-stimulation-protocols-in-women-with-poor-ovarian-response
#3
Bailing Jin, Zhihong Niu, Bufang Xu, Qian Chen, Aijun Zhang
This study aimed to determine whether consecutive ovarian stimulation in follicular and luteal phases within a single menstrual cycle (dual stimulation) is achievable and superior to conventional stimulation for poor ovarian responders (PORs). Data of 260 PORs were retrospectively collected and divided into three groups. Group A comprised of cycles with dual ovarian stimulation (n = 76), which were divided into two subgroups (follicular [group A-F] and luteal phase stimulation [group A-L]); group B comprised of cycles with ovarian stimulation that was performed only in the luteal phase (n = 52)...
February 6, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29404451/microrna-therapy-inhibits-hepatoblastoma-growth-in-vivo-by-targeting-%C3%AE-catenin-and-wnt-signaling
#4
Emilie Indersie, Sarah Lesjean, Katarzyna B Hooks, Francis Sagliocco, Tony Ernault, Stefano Cairo, Maria Merched-Sauvage, Anne Rullier, Brigitte Le Bail, Sophie Taque, Michael Grotzer, Sophie Branchereau, Catherine Guettier, Monique Fabre, Laurence Brugières, Martin Hagedorn, Marie-Annick Buendia, Christophe F Grosset
Hepatoblastoma (HBL) is the most common pediatric liver cancer. In this malignant neoplasm, beta-catenin protein accumulates and increases Wnt signaling due to recurrent activating mutations in the catenin-beta 1 (CTNNB1) gene. Therefore, beta-catenin is a key therapeutic target in HBL. However, controlling beta-catenin production with therapeutic molecules has been challenging. New biological studies could provide alternative therapeutic solutions for the treatment of HBL, especially for advanced tumors and metastatic disease...
April 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29374936/-feasibility-and-safety-of-paclitaxel-eluting-balloon-for-the-treatment-of-de-novo-coronary-lesions
#5
Z H Ni, W H Huang, Y Liu, Z J Chen, J Li, J Q Yang, P C He, Y L Zhou, J Y Chen, J F Luo
Objective: To evaluate the safety and feasibility of treating de novo coronary lesions with paclitaxel-eluting balloon. Methods: This is a retrospective study, which enrolled 76 patients with 80 de novo coronary lesions treated with paclitaxel-eluting balloons(<30% residual stenosis and there was no blood flow limited dissection after pretreatment) from April 2015 to November 2016 in Guangdong general hospital. The data of basic characteristics,procedures,devices and follow-up information were retrieved and analyzed...
January 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29372576/long-term-outcomes-of-rotational-atherectomy-of-underexpanded-stents-a-single-center-experience
#6
Marco Hernández-Enríquez, Francisco Campelo-Parada, Thibault Lhermusier, Frédéric Bouisset, Jérôme Roncalli, Meyer Elbaz, Didier Carrié, Nicolas Boudou
OBJECTIVES: To analyze the procedural and long-term outcomes of the use of rotational atherectomy (RA) in underexpanded stents in our cohort and to provide an overview of currently available data on this technique. BACKGROUND: Stent underexpansion (SU) has been related to stent thrombosis and restenosis. RA has been used to treat undilatable SU as a bail-out strategy with encouraging results. METHODS: This is an observational, single-center study...
January 25, 2018: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29366018/alirocumab-efficiently-reduces-lp-a-levels-by-lowering-apolipoprotein-a-apo-a-production-rate-in-non-human-primates-nhp
#7
Mikaël Croyal, Thi-Thu-Trang Tran, Rose-Hélène Blanchard, Jean-Chistophe Le Bail, Elise Villard, Bruno Poirier, Aurélie Thédrez, Michel Krempf, Christophe Boixel, Gilles Lambert, Etienne Guillot
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29349434/a-novel-application-of-the-culotte-stent-technique-to-bail-out-a-jailed-common-iliac-artery
#8
Hideto Sangen, Shuhei Tara, Takahisa Tanaka, Hitoshi Takano, Kunio Tanaka, Wataru Shimizu
Implanting a self-expandable stent at the ostium of the common iliac artery (CIA) may lead to coverage of the orifice of the contralateral CIA. Here, we describe a novel application of the culotte stent technique using a balloon-expandable stent to bail out an ostial stenotic legion of a jailed CIA due to prior self-expandable stent placement. The bilateral CIAs were revascularized by culotte stenting, and patency of the stents was confirmed 3 years after the procedure. The culotte stent technique was successfully applied to an ostial stenotic lesion of a jailed CIA...
December 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29345590/what-is-the-role-for-glycoprotein-iib-iiia-inhibitor-use-in-the-catheterisation-laboratory-in-the-current-era
#9
Andrea Rubboli, Giuseppe Patti
BACKGROUND: In the era of dual antiplatelet therapy of aspirin and clopidogrel and systematic stent implantation, glycoprotein IIb/IIIa inhibitors (GPI), including abciximab, eptifibatide and tirofiban, proved beneficial in improving early outcome of percutaneous coronary intervention (PCI), especially in higher risk clinical and/or anatomical subsets. This was associated however, with an increased incidence of bleeding complications. OBJECTIVE: To review whether the established results of GPI in PCI are maintained in the contemporary era of more effective antiplatelet agents (i...
January 16, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29328194/subwavelength-wave-manipulation-in-a-thin-surface-wave-bandgap-crystal
#10
Zhen Gao, Zhuoyuan Wang, Baile Zhang
It has been recently reported that the unit cell of wire media metamaterials can be tailored locally to shape the flow of electromagnetic waves at deep-subwavelength scales [Nat. Phys.9, 55 (2013)NPAHAX1745-247310.1038/nphys2480]. However, such bulk structures have a thickness of at least the order of wavelength, thus hindering their applications in the on-chip compact plasmonic integrated circuits. Here, based upon a Sievenpiper "mushroom" array [IEEE Trans. Microwave Theory Tech.47, 2059 (1999)IETMAB0018-948010...
January 1, 2018: Optics Letters
https://www.readbyqxmd.com/read/29325975/procedural-outcomes-and-long-term-survival-associated-with-lead-extraction-in-patients-with-abandoned-leads
#11
Faisal M Merchant, Thor Tejada, Adarsh Patel, Jad El-Khalil, Yaanik Desai, Brent Keeling, Omar M Lattouf, Angel R Leon, Mikhael F El-Chami
BACKGROUND: The decision to abandon or extract superfluous sterile leads is controversial. OBJECTIVE: To compare procedural outcomes and long-term survival of patients with and without abandoned leads undergoing lead extraction (LE). METHODS: Retrospective review of all patients undergoing transvenous LE at our institution from Jan. 2007 to May 2016. Patients were stratified into two groups based on the presence (Group 1) or absence (Group 2) of abandoned leads...
January 8, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29310865/neural-network-disturbance-observer-based-distributed-finite-time-formation-tracking-control-for-multiple-unmanned-helicopters
#12
Dandan Wang, Qun Zong, Bailing Tian, Shikai Shao, Xiuyun Zhang, Xinyi Zhao
The distributed finite-time formation tracking control problem for multiple unmanned helicopters is investigated in this paper. The control object is to maintain the positions of follower helicopters in formation with external interferences. The helicopter model is divided into a second order outer-loop subsystem and a second order inner-loop subsystem based on multiple-time scale features. Using radial basis function neural network (RBFNN) technique, we first propose a novel finite-time multivariable neural network disturbance observer (FMNNDO) to estimate the external disturbance and model uncertainty, where the neural network (NN) approximation errors can be dynamically compensated by adaptive law...
January 5, 2018: ISA Transactions
https://www.readbyqxmd.com/read/29297359/multiple-kernels-learning-based-biological-entity-relationship-extraction-method
#13
Xu Dongliang, Pan Jingchang, Wang Bailing
BACKGROUND: Automatic extracting protein entity interaction information from biomedical literature can help to build protein relation network and design new drugs. There are more than 20 million literature abstracts included in MEDLINE, which is the most authoritative textual database in the field of biomedicine, and follow an exponential growth over time. This frantic expansion of the biomedical literature can often be difficult to absorb or manually analyze. Thus efficient and automated search engines are necessary to efficiently explore the biomedical literature using text mining techniques...
September 20, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29277373/exertional-tolerance-assessments-after-mild-traumatic-brain-injury-a-systematic-review
#14
REVIEW
Catherine Quatman-Yates, Anna Bailes, Sara Constand, Mary Claire Sroka, Katharine Nissen, Brad Kurowski, Jason Hugentobler
OBJECTIVE: The objective of this study was to review the literature to identify and summarize strategies for evaluating responses to physical exertion after mild traumatic brain injury (mTBI) for clinical and research purposes. DATA SOURCES: PubMed and EBSCOHost through December 31, 2016. STUDY SELECTION: Two independent reviewers selected studies based on the following criteria: 1) inclusion of participants with mTBI/concussion, 2) use of a measurement of physiological or psychosomatic response to exertion, 3) a repeatable description of the exertion protocol was provided, 4) a sample of at least 10 participants with a mean age between 8-65 years, and 5) the article was in English...
December 22, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29240963/proximal-buddy-in-jail-technique-a-bail-out-technique-to-increase-guide-support
#15
Tao Tu, Jianjun Tang, Zhenfei Fang, Xinqun Hu, Liang Tang, Yanshu Zhao, Qiming Liu, Shenghua Zhou
BACKGROUND: During percutaneous coronary intervention, "buddy-in-jail" technique is often used to facilitate stent delivery in complex coronary artery lesions. However, the safety and efficacy of this technique when used with different jailed wire and applied in different target vessel lesions remain elusive. The aim of this retrospective study was to analyze the effectiveness of "buddy-in-jail" technique in the tortuous and rigid lesions of both the common and neighboring coronary arteries...
December 14, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29238476/anti-hyperglycemic-and-antioxidant-potential-of-croton-bonplandianus-bail-fractions-in-correlation-with-polyphenol-content
#16
Uma Dharshini Karuppiah Vijayamuthuramalingam, Rajeswari Rajaram, Kalaivani Madhavaram Kuppusamy, Bhavana Jonnalagadda, Sumathy Arokiasamy
Objectives: Diabetes mellitus, a carbohydrate metabolic disorder, occurs due to absolute or relative deficiency of insulin. Current treatment strategies involve either preventing or delaying the intestinal absorption of glucose to lower the levels of postprandial hyperglycemia (PPHG). Herbal remedies have been since ancient times for treating diabetes mellitus. Therefore, identifying novel phytocompounds with α-amylase and α-glucosidase inhibitory activity that would reduce the glucose absorption as well as the rise in postprandial blood glucose level is vital...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29223516/antimicrobial-activity-of-plazomicin-against-enterobacteriaceae-producing-carbapenemases-from-50-brazilian-medical-centers
#17
Andreza Francisco Martins, Larissa Bail, Carmen Antonia Sanches Ito, Keite da Silva Nogueira, Tanise Vendruscolo Dalmolin, Amanda Silva Martins, Jaime Luis Lopes Rocha, Alisa W Serio, Felipe Francisco Tuon
Plazomicin is a next-generation aminoglycoside with activity against Enterobacteriaceae, including carbapenemase-producing Enterobacteriaceae (CPE). The aim of this study was to evaluate the activity of plazomicin against CPE (Klebsiella spp., Escherichia coli, Serratia spp., Enterobacter spp., Citrobacter spp., Morganella spp., Proteus spp., Providencia spp.) from different Brazilian hospitals. A total of 4000 carbapenem-resistant Enterobacteriaceae isolates were collected from clinical samples in 50 Brazilian hospitals during 2013-2015...
November 10, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29220805/processing-of-wet-kinnow-mandarin-citrus-reticulata-fruit-waste-into-novel-br%C3%A3-nsted-acidic-ionic-liquids-and-their-application-in-hydrolysis-of-sucrose
#18
Pratibha Dwivedi, Mangat Singh, Naina Sehra, Nishant Pandey, Rajender S Sangwan, Bhuwan B Mishra
In citrus processing industries, where up to 60% of the whole fruit is discarded, generates citrus waste (peel, seeds, membrane, and pulp) on a massive scale. The waste does not currently have high-value applications, instead the majority is disposed of or pelletized for animal feed. Therefore, a concise and efficacious protocol for processing of Kinnow mandarin (Citrus reticulata) fruit waste to numerous novel Brønsted acidic ionic liquids (3a-k) have been developed. BAILs were characterized using spectroscopic techniques (FT-IR and NMR)...
December 2, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29211954/sirna-delivery-with-chitosan-influence-of-chitosan-molecular-weight-degree-of-deacetylation-and-amine-to-phosphate-ratio-on-in-vitro-silencing-efficiency-hemocompatibility-biodistribution-and-in-vivo-efficacy
#19
Mohamad Gabriel Alameh, Marc Lavertu, Nicolas Tran-Khanh, Chi-Yuan Chang, Frédéric Lesage, Martine Bail, Vincent Darras, Anik Chevrier, Michael D Buschmann
Chitosan (CS) shows in vitro and in vivo efficacy for siRNA delivery, but with contradictory findings for incompletely characterized systems. To understand which parameters produce effective delivery, a library of precisely characterized chitosans was produced at different DDAs and Mn. Encapsulation and transfection efficiencies were characterized in vitro. Formulations were selected to examine the influence of Mn and N:P ratio on nanoparticle uptake, metabolic activity, genotoxicity, and in vitro transfection...
December 6, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29208565/mismatch-repair-deficient-colorectal-cancer-a-model-of-immunogenic-and-immune-cell-rich-tumor-despite-nonsignificant-pd-l1-expression-in-tumor-cells
#20
Glen Le Flahec, Bogdan Badic, Briac Guibourg, Laurent Doucet, Jean-Pierre Bail, Pascale Marcorelles, Ulrike Schick, Arnaud Uguen
Mismatch repair-deficient colorectal cancers (CRC) are good responders to anti-programmed cell death ligand-1 (PD-L1) immunotherapy, but the value of PD-L1 testing remains unclear. We studied PD-L1 expression and the tumor immune microenvironment in mismatch repair-deficient (dMMR) CRC as a model of good responders to immunotherapy. We examined 35 dMMR and 34 mismatch repair-proficient (pMMR) CRC using immune cell markers (CD3, CD4, CD8, CD20, CD68, and FOXP3) as well as PD-1 and PD-L1 immunohistochemistry staining in whole tumor specimens and tissue microarray slides to compare 4r PD-L1 immunohistochemistry clones (SP142, E1L3N, 22C3, and 28...
December 2, 2017: Human Pathology
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