keyword
MENU ▼
Read by QxMD icon Read
search

CGI

keyword
https://www.readbyqxmd.com/read/29339723/fasoracetam-in-adolescents-with-adhd-and-glutamatergic-gene-network-variants-disrupting-mglur-neurotransmitter-signaling
#1
Josephine Elia, Grace Ungal, Charlly Kao, Alexander Ambrosini, Nilsa De Jesus-Rosario, Lene Larsen, Rosetta Chiavacci, Tiancheng Wang, Christine Kurian, Kanani Titchen, Brian Sykes, Sharon Hwang, Bhumi Kumar, Jacqueline Potts, Joshua Davis, Jeffrey Malatack, Emma Slattery, Ganesh Moorthy, Athena Zuppa, Andrew Weller, Enda Byrne, Yun R Li, Walter K Kraft, Hakon Hakonarson
The glutamatergic neurotransmitter system may play an important role in attention-deficit hyperactivity disorder (ADHD). This 5-week, open-label, single-blind, placebo-controlled study reports the safety, pharmacokinetics and responsiveness of the metabotropic glutamate receptor (mGluR) activator fasoracetam (NFC-1), in 30 adolescents, age 12-17 years with ADHD, harboring mutations in mGluR network genes. Mutation status was double-blinded. A single-dose pharmacokinetic profiling from 50-800 mg was followed by a single-blind placebo at week 1 and subsequent symptom-driven dose advancement up to 400 mg BID for 4 weeks...
January 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29331848/repetitive-transcranial-magnetic-stimulation-for-apathy-in-mild-cognitive-impairment-a-double-blind-randomized-sham-controlled-cross-over-pilot-study
#2
Prasad R Padala, Kalpana P Padala, Shelly Y Lensing, Andrea N Jackson, Cassandra R Hunter, Christopher M Parkes, Richard A Dennis, Melinda M Bopp, Ricardo Caceda, Mark S Mennemeier, Paula K Roberson, Dennis H Sullivan
Apathy is a common and disabling behavioral concomitant of many neurodegenerative conditions. The presence of apathy with Mild Cognitive Impairment (MCI) is linked with heightened rates of conversion to Alzheimer's disease. Improving apathy may slow the neurodegenerative process. The objective was to establish the efficacy of repetitive transcranial magnetic stimulation (rTMS) in improving apathy in older adults with MCI. An 8-week, double-blind, randomized, sham-controlled cross-over study was conducted in nine subjects (66 ± 9 years) with apathy and MCI...
January 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29330071/onabotulinumtoxina-for-the-treatment-of-post-stroke-distal-lower-limb-spasticity-a-randomized-trial
#3
Theodore Wein, Alberto Esquenazi, Wolfgang H Jost, Anthony B Ward, Grace Pan, Rozalina Dimitrova
BACKGROUND: Post-stroke distal lower limb spasticity impairs mobility, limiting activities of daily living, requiring additional caregiver time. OBJECTIVE: To evaluate the efficacy, safety, and sustained benefit of onabotulinumtoxinA in adults with post-stroke lower limb spasticity (PSLLS). DESIGN: A multicenter, randomized, double-blind, phase 3, placebo-controlled trial. SETTING: 60 study centers across North America, Europe, Russia the United Kingdom, and South Korea...
January 9, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29329498/treatment-outcomes-of-acute-bipolar-depressive-episode-with-psychosis
#4
Marco Antonio Caldieraro, Steven Dufour, Louisa G Sylvia, Keming Gao, Terence A Ketter, William V Bobo, Samantha Walsh, Jessica Janos, Mauricio Tohen, Noreen A Reilly-Harrington, Susan L McElroy, Richard C Shelton, Charles L Bowden, Thilo Deckersbach, Andrew A Nierenberg
BACKGROUND: The impact of psychosis on the treatment of bipolar depression is remarkably understudied. The primary aim of this study was to compare treatment outcomes of bipolar depressed individuals with and without psychosis. The secondary aim was to compare the effect of lithium and quetiapine, each with adjunctive personalized treatments (APTs), in the psychotic subgroup. METHODS: We assessed participants with DSM-IV bipolar depression included in a comparative effectiveness study of lithium and quetiapine with APTs (the Bipolar CHOICE study)...
January 12, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29326098/cognitive-and-behavioral-skills-exercises-completed-by-patients-with-major-depression-during-smartphone-cognitive-behavioral-therapy-secondary-analysis-of-a-randomized-controlled-trial
#5
Toshi A Furukawa, Masaru Horikoshi, Hirokazu Fujita, Naohisa Tsujino, Ran Jinnin, Yuki Kako, Sei Ogawa, Hirotoshi Sato, Nobuki Kitagawa, Yoshihiro Shinagawa, Yoshio Ikeda, Hissei Imai, Aran Tajika, Yusuke Ogawa, Tatsuo Akechi, Mitsuhiko Yamada, Shinji Shimodera, Norio Watanabe, Masatoshi Inagaki, Akio Hasegawa
BACKGROUND: A strong and growing body of evidence has demonstrated the effectiveness of cognitive behavioral therapy (CBT), either face-to-face, in person, or as self-help via the Internet, for depression. However, CBT is a complex intervention consisting of several putatively effective components, and how each component may or may not contribute to the overall effectiveness of CBT is poorly understood. OBJECTIVE: The aim of this study was to investigate how the users of smartphone CBT use and benefit from various components of the program...
January 11, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29313415/a-controlled-trial-of-extended-release-guanfacine-and-psychostimulants-on-executive-function-and-adhd
#6
Judy P M van Stralen
OBJECTIVE: To evaluate the effectiveness of guanfacine extended-release (GXR) versus placebo as adjunct therapy to usual care stimulant therapy in improving executive function in children aged 6 to 12 years diagnosed with ADHD. METHOD: In this single center, double-blind placebo-controlled crossover trial, subjects continued to take their psychostimulant and were randomly assigned at baseline to receive active treatment or placebo first. Efficacy measures included Behavioural Rating Inventory of Executive Function (BRIEF-P), ADHD Rating Scale IV (ADHD-RS IV), and Clinical Global Impressions of Severity of Illness (CGI-S) and Improvement (CGI-I) scales...
January 1, 2018: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29298284/adherence-self-stigma-and-discontinuation-of-pharmacotherapy-in-patients-with-anxiety-disorders-cross-sectional-study
#7
Andrea Cinculova, Jan Prasko, Dana Kamaradova, Marie Ociskova, Klara Latalova, Kristyna Vrbova, Radim Kubinek, Barbora Mainerova, Ales Grambal, Anezka Tichackova
INTRODUCTION: Treatment adherence is one of the main factors affecting the success of treatment and, secondarily, the quality of life and social adaptation of the patients. The aim of this study was to investigate the association between self-stigmatization, treatment adherence and history of discontinuation of drug treatment. METHODS: The cross-sectional study was conducted on 120 (98 completed all the questionnaires) neurotic outpatients treated in the University Hospital Olomouc...
December 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29298077/fibromyalgia-with-gabapentin-and-osteopathic-manipulative-medicine-a-pilot-study
#8
Cynthia Marske, Natasha Bernard, Alison Palacios, Cary Wheeler, Ben Preiss, Mackenzie Brown, Saveri Bhattacharya, Gloria Klapstein
OBJECTIVES: This pilot study compares the safety and efficacy of three treatments in reducing pain and improving fibromyalgia symptoms. DESIGN: This study was an 8-week prospective, single center feasibility study. SETTING AND SUBJECTS: Forty subjects were recruited from Solano, Sonoma, and Contra Costa counties of California in 2006-2009. Subjects were aged 18-65 and met the American College of Rheumatology (ACR) 1990 criteria for fibromyalgia...
January 3, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29297110/subtyping-schizophrenia-by-social-functioning-a-pragmatic-proposal-for-clinics-and-research
#9
Takefumi Suzuki
Schizophrenia has been claimed to be a "heterogeneous" disorder despite the fact that a diagnosis is made without reliable biomarkers but sorely with a constellation of "common" observable symptoms that however may be overlooked. Alternatively functional impairments are the prerequisite to make a diagnosis and may be simpler and more pragmatic to express objectively. It would then be reasonable to categorize patients according to the magnitude of psychosocial impairments, as has been done in terms of the severity of "classical" symptoms...
January 3, 2018: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29291581/analysis-on-speech-signal-features-of-manic-patients
#10
Jing Zhang, Zhongde Pan, Chao Gui, Ting Xue, Yezhe Lin, Jie Zhu, Donghong Cui
Given the lack of effective biological markers for early diagnosis of bipolar mania, and the tendency for voice fluctuation during transition between mood states, this study aimed to investigate the speech features of manic patients to identify a potential set of biomarkers for diagnosis of bipolar mania. 30 manic patients and 30 healthy controls were recruited and their corresponding speech features were collected during natural dialogue using the Automatic Voice Collecting System. Bech-Rafaelsdn Mania Rating Scale (BRMS) and Clinical impression rating scale (CGI) were used to assess illness...
December 22, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29289965/the-influence-of-the-repetitive-transcranial-magnetic-stimulation-on-sleep-quality-in-depression
#11
Jakub Maria Antczak, Anna Poleszczyk, Adam Wichniak, Maria Rakowicz, Tadeusz Jerzy Parnowski
OBJECTIVES: Repetitive transcranial magnetic stimulation (rTMS) improves mood in depression. In this study we investigated whether the depression-related insomnia is modulated by this therapeutic method. METHODS: We examined 13 patients (mean age 50.6±13.9; 11 women) with bipolar or unipolar depression. During 20 consecutive days, excluding Saturdays and Sundays, they underwent 20 daily sessions of 10 Hz rTMS over the left dorsolateral prefrontal cortex (DLPFC)...
October 29, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29281820/allele-specific-dna-methylation-and-its-interplay-with-repressive-histone-marks-at-promoter-mutant-tert-genes
#12
Josh Lewis Stern, Richard D Paucek, Franklin W Huang, Mahmoud Ghandi, Ronald Nwumeh, James C Costello, Thomas R Cech
A mutation in the promoter of the Telomerase Reverse Transcriptase (TERT) gene is the most frequent noncoding mutation in cancer. The mutation drives unusual monoallelic expression of TERT, allowing immortalization. Here, we find that DNA methylation of the TERT CpG island (CGI) is also allele-specific in multiple cancers. The expressed allele is hypomethylated, which is opposite to cancers without TERT promoter mutations. The continued presence of Polycomb repressive complex 2 (PRC2) on the inactive allele suggests that histone marks of repressed chromatin may be causally linked to high DNA methylation...
December 26, 2017: Cell Reports
https://www.readbyqxmd.com/read/29278968/clinical-improvement-relapse-and-treatment-adherence-with-paliperidone-palmitate-1-month-formulation-1-year-treatment-in-a-naturalistic-outpatient-setting
#13
Rosaria Di Lorenzo, Michela Cameli, Chiara Piemonte, Marisa Bolondi, Giulia Landi, Gabriella Pollutri, Ludovica Spattini, Valentina Moretti, Paola Ferri
PURPOSE: To evaluate paliperidone palmitate 1-month formulation (PP1M) effectiveness in a naturalistic outpatient psychiatric setting. MATERIALS AND METHODS: We collected data from 50 outpatients affected by schizophrenia disorders treated with PP1M for 12 months in an Italian Mental Health Department. After analyzing selected demographic, clinical and pharmacological variables, we performed mirror analysis to compare psychiatric hospitalizations and urgent consultations required by the same patient 6 and 12 months before and after PP1M implementation (primary outcome)...
December 27, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29276351/abnormal-concentration-of-gaba-and-glutamate-in-the-prefrontal-cortex-in-schizophrenia-an-in-vivo-1h-mrs-study
#14
Tianyi Chen, Yingchan Wang, Jianye Zhang, Zuowei Wang, Jiale Xu, Yao Li, Zhilei Yang, Dengtang Liu
Background: The etiology and pathomechanism of schizophrenia are unknown. The traditional dopamine (DA) hypothesis is unable to fully explain its pathology and therapeutics. The glutamate (Glu) and γ-aminobutyric acid (GABA) hypotheses suggest Glu or GABA concentrations are abnormal in the brains of patients with schizophrenia. Magnetic resonance spectroscopy (MRS) show glutamate level increases in the ventromedial prefrontal cortex (vmPFC) including the anterior cingulated cortex (ACC) in those with schizophrenia...
October 25, 2017: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29250653/integrative-clinico-biological-pharmacogenetic-neuroimagistic-neuroendocrinological-and-psychological-correlations-in-depressive-and-anxiety-disorders
#15
Lavinia Maria Hogea, Laura Alexandra Nussbaum, Daniela Veronica Chiriac, LuminiŢa Ştefania Ageu, Nicoleta Ioana Andreescu, Mirela Loredana Grigoraş, Roxana Folescu, Ana Cristina Bredicean, Maria Puiu, Elena Cecilia Ildikó Roşca, Mihaela Adriana Simu, Codrina Mihaela Levai
We approach the theme of modern treatment strategies, based on clinico-biological, pharmacogenetic, neuroimagistic, neuroendocrinological and psychological integrative correlations in the management of depressive and comorbid anxiety disorders. We target to evaluate the efficacy of the pharmacogenetic testing and the evolution, functioning of patients in correlation with specific neurobiological, neuroimagistic and neuroendocrinological markers. Our research was conducted between 2010-2016 on 80 children and adolescents with depressive and comorbid anxiety disorders - 40 children (G1 group), who benefited in choosing the pharmacotherapy from pharmacogenetic testing and 40 children without testing (G2 group)...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29241357/cannabidiol-cbd-as-an-adjunctive-therapy-in-schizophrenia-a-multicenter-randomized-controlled-trial
#16
Philip McGuire, Philip Robson, Wieslaw Jerzy Cubala, Daniel Vasile, Paul Dugald Morrison, Rachel Barron, Adam Taylor, Stephen Wright
OBJECTIVE: Research in both animals and humans indicates that cannabidiol (CBD) has antipsychotic properties. The authors assessed the safety and effectiveness of CBD in patients with schizophrenia. METHOD: In an exploratory double-blind parallel-group trial, patients with schizophrenia were randomized in a 1:1 ratio to receive CBD (1000 mg/day; N=43) or placebo (N=45) alongside their existing antipsychotic medication. Participants were assessed before and after treatment using the Positive and Negative Syndrome Scale (PANSS), the Brief Assessment of Cognition in Schizophrenia (BACS), the Global Assessment of Functioning scale (GAF), and the improvement and severity scales of the Clinical Global Impressions Scale (CGI-I and CGI-S)...
December 15, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29238395/cognitive-dysfunction-in-asian-patients-with-depression-cogdad-a-cross-sectional-study
#17
Srisurapanont Manit, Mok Yee Ming, Yang Yen Kuang, Chan Herng-Nieng, Della Constantine D, Zainal Nor Zuraida, Jambunathan Stephen, Amir Nurmiati, Kalita Pranabi
Background: Cognitive dysfunction is a predominant symptom of Major Depressive Disorder (MDD), contributing to functional impairment. Objective: The primary objective of this study was to assess and describe perceived cognitive dysfunction amongst Asian patients diagnosed with MDD. The secondary objective was to explore the associations between depression severity, perceived cognitive dysfunction and functional disability. Methods: This was a multi-country, multi-centre, cross-sectional study...
2017: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/29237195/-interdisciplinary-inpatient-treatment-for-adolescents-and-young-adults-16%C3%A2-%C3%A2-25-years-with-mental-illness-in-adolescent-psychiatry
#18
Anne Karow, Michael Lipp, Eva Schweigert, Mary Sengutta, Gaby Wiltfang, Linus Wittmann, Martin Lambert, Carola Bindt, Jürgen Gallinat, Michael Schulte-Markwort
Objective The investigation of clinical characteristics of patients in adolescence psychiatry relevant for transition medicine. Methodology Sociodemographic and clinical data (SCID I/II, SIPS/SOPS, SPI-A, GAF, CGI) were consecutively taken from the interdisciplinary inpatient treatment centre for adolescents and young adults with mental disorders (N = 229, aged 16 - 25). Results Average age was 19 years (38 % male, 23 % migration background). A high proportion of early mental illnesses and comorbidities (66 %), psychosis risk syndromes (20 %) and suicidality (54 %), treatment discontinuation (33 %) with daily-life, social and family stress factors (52 % positive family history, 34 % trauma) were observed and a persistently high level of support and treatment was needed despite a significant clinical improvement (p < 0...
December 13, 2017: Psychiatrische Praxis
https://www.readbyqxmd.com/read/29227898/responsiveness-of-the-personal-and-social-performance-scale-in-patients-with-schizophrenia
#19
En-Chi Chiu, Tsui-Mei Hung, Chiu-Min Huang, Shu-Chun Lee, Ching-Lin Hsieh
The responsiveness (ability to detect change) of the Personal and Social Performance scale (PSP) is largely unknown, limiting its use as an outcome measure. The purpose of this study was to examine both internal and external responsiveness of the PSP in patients with schizophrenia in the acute phase. Eighty patients were administered the PSP and the Clinical Global Impression-Severity scale (CGI-S) at admission and at discharge. We used the standardized effect size, the standardized response mean, and paired t-test for examining internal responsiveness...
November 27, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29224411/change-in-quantitative-eeg-theta-cordance-as-a-potential-predictor-of-repetitive-transcranial-magnetic-stimulation-clinical-outcome-in-major-depressive-disorder
#20
Aimee M Hunter, Thien X Nghiem, Ian A Cook, David E Krantz, Michael J Minzenberg, Andrew F Leuchter
Repetitive transcranial magnetic stimulation (rTMS) has demonstrated efficacy in major depressive disorder (MDD), although clinical outcome is variable. Change in the resting-state quantitative electroencephalogram (qEEG), particularly in theta cordance early in the course of treatment, has been linked to antidepressant medication outcomes but has not been examined extensively in clinical rTMS. This study examined change in theta cordance over the first week of clinical rTMS and sought to identify a biomarker that would predict outcome at the end of 6 weeks of treatment...
November 1, 2017: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
keyword
keyword
38219
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"