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https://www.readbyqxmd.com/read/29783067/motor-retraining-more-for-functional-movement-disorders-outcomes-from-a-one-week-multidisciplinary-rehabilitation-program
#1
Alexandra Jacob, Darryl Kaelin, Abbey Roach, Craig Ziegler, Kathrin LaFaver
BACKGROUND: Functional Movement Disorders (FMD) are conditions of abnormal motor control thought to be caused by psychological factors. These disorders are commonly seen in neurological practice and prognosis is often poor. No consensus treatment guidelines have been established, however the role of physical therapy in addition to psychotherapy has increasingly been recognized. This study reports patient outcomes from a multidisciplinary FMD treatment program using motor retraining (MoRe) strategies...
May 18, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29780342/long-term-efficacy-of-psychosocial-treatments-for-adults-with-attention-deficit-hyperactivity-disorder-a-meta-analytic-review
#2
Carlos López-Pinar, Sonia Martínez-Sanchís, Enrique Carbonell-Vayá, Javier Fenollar-Cortés, Julio Sánchez-Meca
Background: Recent evidence suggests that psychosocial treatments, particularly cognitive-behavioral therapy (CBT), are effective interventions for adult attention deficit hyperactivity disorder (ADHD). The objective of this review was to determine the long-term efficacy of psychosocial interventions in improving clinically relevant variables, including ADHD core symptoms, clinical global impression (CGI), and global functioning. Methods: In total, nine randomized controlled trials and three uncontrolled single-group pretest-posttest studies were included...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29770158/whodas-2-0-as-a-measure-of-severity-of-illness-results-of-a-flda-analysis
#3
Alba Sedano-Capdevila, María Luisa Barrigón, David Delgado-Gomez, Igor Barahona, Fuensanta Aroca, Inmaculada Peñuelas-Calvo, Carolina Miguelez-Fernandez, Alba Rodríguez-Jover, Susana Amodeo-Escribano, Marta González-Granado, Enrique Baca-García
WHODAS 2.0 is the standard measure of disability promoted by World Health Organization whereas Clinical Global Impression (CGI) is a widely used scale for determining severity of mental illness. Although a close relationship between these two scales would be expected, there are no relevant studies on the topic. In this study, we explore if WHODAS 2.0 can be used for identifying severity of illness measured by CGI using the Fisher Linear Discriminant Analysis (FLDA) and for identifying which individual items of WHODAS 2...
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29768955/results-of-a-real-world-study-on-vortioxetine-in-patients-with-major-depressive-disorder-in-south-east-asia-revida
#4
Cheuk Ngen Chin, Azhar Zain, Solaphat Hemrungrojn, Eng Khean Ung, Patanon Kwansanit, Koon Choong Au Yong, Marvin Swee Woon Chong, Chalowat Inpa, Teck Hoe Yen, Boon Beng David Yeoh, Liam Kai Tay, Carmina Bernardo, Lionel Chee-Chong Lim, Chin Hong Yap, Calvin Fones, Ashwini Nayak, Lars Nelleman
OBJECTIVE: The REVIDA study aimed to assess the evolution of major depression symptoms in South East Asian (SEA) patients treated with vortioxetine for major depression in real-world clinical practice. METHODS: This non-interventional study was conducted from Aug 2016 to Apr 2017. A total of 138 patients (aged 18-65 years) with an active episode of major depression were recruited from Malaysia, Philippines, Singapore, and Thailand. Vortioxetine was initiated on the first visit and patients were followed for 3 months...
May 17, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29751741/detecting-pre-death-grief-in-family-caregivers-of-persons-with-dementia-measurement-equivalence-of-the-mandarin-chinese-version-of-marwit-meuser-caregiver-grief-inventory
#5
Tau Ming Liew, Philip Yap, Nan Luo, Soo Boon Hia, Gerald Choon-Huat Koh, Bee Choo Tai
BACKGROUND: Pre-death grief (PDG) is a key challenge faced by caregivers of persons with dementia (PWD). Marwit-Meuser Caregiver Grief Inventory (MM-CGI) and its abbreviated MM-CGI-Short-Form (MM-CGI-SF) are among the few empirically-developed scales that detect PDG. However, they have not had a Mandarin-Chinese version even though Chinese-speaking populations have among the largest number of PWD. We produced a Mandarin-Chinese version of MM-CGI and evaluated whether it had equivalent scores and similar psychometric properties to the English version...
May 11, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29744300/gene-expression-profiles-and-pathway-enrichment-analysis-of-human-osteosarcoma-cells-exposed-to-sorafenib
#6
Zhehao Dai, Haoyu Tang, Yue Pan, Junquan Chen, Yongping Li, Jun Zhu
Sorafenib is an inhibitor of a variety of tyrosine kinase receptors used to treat various cancers including hepatocellular, renal cell and thyroid carcinoma. It has been shown to change various targets associated with osteosarcoma, but the detailed mechanism remains unclear. In order to identify key genes, enriched pathways and important modules during the exposure of human osteosarcoma cells to sorafenib, data for gene expression profiles (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE53155) were downloaded from the GEO database...
May 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29739406/dna-methylation-in-the-apoe-genomic-region-is-associated-with-cognitive-function-in-african-americans
#7
Jiaxuan Liu, Wei Zhao, Erin B Ware, Stephen T Turner, Thomas H Mosley, Jennifer A Smith
BACKGROUND: Genetic variations in apolipoprotein E (APOE) and proximal genes (PVRL2, TOMM40, and APOC1) are associated with cognitive function and dementia, particularly Alzheimer's disease. Epigenetic mechanisms such as DNA methylation play a central role in the regulation of gene expression. Recent studies have found evidence that DNA methylation may contribute to the pathogenesis of dementia, but its association with cognitive function in populations without dementia remains unclear...
May 8, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/29724638/placid-study-a-randomized-trial-comparing-the-efficacy-and-safety-of-inhaled-loxapine-versus-intramuscular-aripiprazole-in-acutely-agitated-patients-with-schizophrenia-or-bipolar-disorder
#8
Luis San, Gemma Estrada, Natalia Oudovenko, Francisco Montañés, Natalia Dobrovolskaya, Olga Bukhanovskaya, Mikhail Popov, Eduard Vieta
The aim of the study was to investigate the efficacy and safety of inhaled loxapine compared with the intramuscular (IM) antipsychotic aripiprazole in acutely agitated patients with schizophrenia or bipolar I disorder. PLACID was an assessor-blind, parallel-group trial conducted in 23 centres in the Czech Republic, Germany, Spain, and Russia. Patients (aged 18-65 years) diagnosed with schizophrenia or bipolar I disorder experiencing acute agitation (Clinical Global Impression [CGI]-Severity score ≥ 4) while hospitalized or attending an emergency room were randomized to receive up to two doses of inhaled loxapine 9...
May 1, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29723991/the-expression-pattern-of-plin2-in-differentiated-adipocytes-from-qinchuan-cattle-analysis-of-its-protein-structure-and-interaction-with-cgi-58
#9
Peiwei Li, Yaning Wang, Le Zhang, Yue Ning, Linsen Zan
PLIN2 (Perilipin-2) is a protein that can anchor on the membrane of lipid droplets (LDs), playing a vital role in the early formation of LDs and in the regulation of LD metabolism in many types of cells. However, little research has been conducted in cattle adipocytes. In the present study, we found that the expression of PLIN2 mRNA peaks at Day 2 during cattle adipocyte differentiation ( p < 0.01), but PLIN2 protein levels maintain high abundance until Day 4 and then decrease sharply. We first built an interaction model using PyMOL...
May 1, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29713951/accommodation-and-health-costs-of-deinstitutionalized-people-with-mental-illness-living-in-residential-services-in-brazil
#10
Denise Razzouk
BACKGROUND: Health costs are the main hindrances for expanding community mental health services. Exploring patient profiles and cost predictors may be useful for optimising financial resources. However, the deinstitutionalisation process may burden health budgets in terms of supporting multiple community services based on varying levels of need. OBJECTIVE: This study assessed accommodation and health service costs, quality of life and clinical and psychosocial profiles among individuals receiving mental healthcare through residential services...
April 30, 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29702377/severity-of-mental-health-concerns-in-pediatric-primary-care-and-the-role-of-child-psychiatry-access-programs
#11
Rheanna Platt, Sean Pustilnik, Elizabeth Connors, Nicole Gloff, Kelly Bower
OBJECTIVE: To describe the clinical severity of patients for whom Primary Care Providers (PCPs) requested consultation from Maryland's Child Psychiatry Access Program (CPAP), and examine the proportion and associated characteristics of severe cases being managed alone by PCPs versus co-managed with mental health specialists. METHODS: Data were collected for 872 cases based on calls received between October 2012 and December 2016. Severity was measured by consultant-assigned Clinical Global Impression-Severity (CGI-S) score...
February 24, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29701595/factors-influencing-advance-directives-among-psychiatric-inpatients-in-india
#12
Guru S Gowda, Eric O Noorthoorn, Peter Lepping, Channaveerachari Naveen Kumar, Raveesh Bevinahalli Nanjegowda, Suresh Bada Math
OBJECTIVES: Advance directives are documents stating treatment preferences in case of future lack of decision making capacity. In India, as in many other countries, legislators advocate Psychiatric Advance Directives (PADs), while evidence on its use is limited. This study examined factors influencing PADs by gathering inpatients perspectives on PADs at discharge and investigating patient characteristics associated with the expression of treatment wishes in PADs. METHODS: We conducted a hospital based descriptive study in Bangalore...
January 2018: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/29696357/stigma-experiences-and-perceived-stigma-in-patients-with-first-episode-schizophrenia-in-the-course-of-1-year-after-their-first-in-patient-treatment
#13
Harald Zäske, Michael Linden, Detlef Degner, Maria Jockers-Scherübl, Stefan Klingberg, Joachim Klosterkötter, Wolfgang Maier, Hans-Jürgen Möller, Heinrich Sauer, Andrea Schmitt, Wolfgang Gaebel
Patients with schizophrenia suffer from stigma and discrimination due to their illness. Yet it is not well examined how experiences of stigma and discrimination express at the early illness stage and how they develop subsequently. Therefore, clinical and psycho-social correlates of stigma experiences and perceived stigma are analyzed in patients with first-episode schizophrenia over the course of 1 year after their first in-patient treatment. Questionnaire data assessed within the multi-centre-RCT "First-Episode Study" of the German Research Network on Schizophrenia were analyzed...
April 25, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29696355/risk-of-mild-head-injury-in-preschool-children-relationship-to-attention-deficit-hyperactivity-disorder-symptoms
#14
Hatice Altun, İdiris Altun
AIM: To investigate whether there is an association between mild head injury (MHI) and attention deficit hyperactivity disorder (ADHD) symptoms in preschool children. METHODS: The study included a patient group of 30 children aged 3-6 years with mild head trauma and a control group of 30 healthy and age- and sex-matched children. The symptoms of ADHD were evaluated using the Conners' Parent Rating Scale-Revised Long (CPRS-RL) form. RESULTS: The mean age was 4...
April 25, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29695702/-prediction-of-bacterial-and-archaeal-allergenicity-with-allpred-program
#15
A O Bragin, V S Sokolov, P S Demenkov, T V Ivanisenko, E Yu Bragina, Yu G Matushkin, V A Ivanisenko
Nowadays, allergic disorders have become one of the most important social problems in the world. This can be related to the advent of new allergenic agents in the environment, as well as an increasing density of human contact with known allergens, including various proteins. Thus, the development of computer programs designed for the prediction of allergenic properties of proteins becomes one of the urgent tasks of mo dern bioinformatics. Previously we developed a web accessible Allpred Program (http://www-bionet...
March 2018: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/29692860/the-long-term-outcome-of-patients-with-heroin-use-disorder-dual-disorder-chronic-psychosis-after-admission-to-enhanced-methadone-maintenance
#16
Angelo G I Maremmani, Alessandro Pallucchini, Luca Rovai, Silvia Bacciardi, Vincenza Spera, Marco Maiello, Giulio Perugi, Icro Maremmani
Background: Over-standard methadone doses are generally needed in the treatment of heroin use disorder (HUD) patients that display concomitant high-severity psychopathological symptomatology. A flexible dosing regimen may lead to higher retention rates in dual disorder (DD), as we demonstrated in bipolar 1 HUD patients, leading to outcomes that are as satisfactory as those of HUD patients without high-severity psychopathological symptomatology. Objective: This study aimed to compare the long-term outcomes of treatment-resistant chronic psychosis HUD patients (PSY-HUD) with those of peers without dual disorder (HUD)...
2018: Annals of General Psychiatry
https://www.readbyqxmd.com/read/29687019/phosphodiesterase-5-inhibition-potentiates-cerebrovascular-reactivity-in-chronic-traumatic-brain-injury
#17
Kimbra Kenney, Franck Amyot, Carol Moore, Margalit Haber, L Christine Turtzo, Christian Shenouda, Erika Silverman, Yunhua Gong, Bao-Xi Qu, Leah Harburg, Eric M Wassermann, Hanzhang Lu, Ramon Diaz-Arrastia
Background: Traumatic cerebrovascular injury (TCVI), a common consequence of traumatic brain injury (TBI), presents an attractive therapeutic target. Because phosphodiesterase-5 (PDE5) inhibitors potentiate the action of nitric oxide (NO) produced by endothelial cells, they are candidate therapies for TCVI. This study aims to: (1) measure cerebral blood flow (CBF), cerebrovascular reactivity (CVR), and change in CVR after a single dose of sildenafil (ΔCVR) in chronic TBI compared to uninjured controls; (2) examine the safety and tolerability of 8-week sildenafil administration in chronic symptomatic moderate/severe TBI patients; and as an exploratory aim, (3) assess the effect of an 8-week course of sildenafil on chronic TBI symptoms...
April 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29684537/genetic-imaging-study-with-tc-99m-trodat-1-spect-in-adolescents-with-adhd-using-oros-methylphenidate
#18
Aynur Pekcanlar Akay, Gamze Çapa Kaya, Samet Kose, Çiğdem Eresen Yazıcıoğlu, Handan Özek Erkuran, Sevay Alşen Güney, Kaya Oğuz, Duygu Keskin, Burak Baykara, Neslihan İnal Emiroğlu, Mine Şencan Eren, Sefa Kızıldağ, Türkan Ertay, Dua Özsoylu, Süha Miral, Hatice Durak, Ali Saffet Gönül, Luis Augusto Rohde
AIM: To examine theeffects on the brain of 2-month treatment withamethylphenidate extended-release formulation (OROS-MPH) using [Tc-99m ] TRODAT-1SPECT in a sample of treatment-naïve adolescents with Attention Deficit/Hyperactivity Disorder (ADHD). In addition, to assess whether risk alleles (homozygosity for 10-repeat allele at the DAT1 gene were associated with alterations in striatal DAT availability. METHODS: Twenty adolescents with ADHD underwent brain single-photon emission computed tomography (SPECT) scans with [Tc-99m ] TRODAT-1 at baseline and two months after starting OROS-MPH treatment with dosages up to 1 mg/kg/day...
April 20, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29680728/respiratory-subtype-of-panic-disorder-can-serum-phosphate-levels-be-a-possible-outcome-to-group-cognitive-behavior-therapy
#19
Pedro Beria, Ana Cristina W Viana, Andressa Behenck, Elizeth Heldt, Gisele Gus Manfro, Carolina Blaya Dreher
OBJECTIVE: Panic disorder (PD) respiratory subtype (RS) was described in order to cluster patients according to their symptoms. These patients are characterized by experiencing a relatively high number of noticeable respiratory symptoms during a panic attack (PA) and a higher reactivity to CO2 . In this study, we aimed to evaluate the clinical relevance of this diagnostic category, evaluating if there are different responses to cognitive-behavioral therapy in patients with panic disorder RS as compared to those with the non-respiratory subtype (NRS), using serum phosphate as a biological marker...
April 12, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29680437/treatment-of-restless-legs-syndrome-willis-ekbom-disease-with-the-non-selective-ent1-ent2-inhibitor-dipyridamole-testing-the-adenosine-hypothesis
#20
Diego Garcia-Borreguero, Xavier Guitart, Celia Garcia Malo, Irene Cano-Pumarega, Juan José Granizo, Sergi Ferré
OBJECTIVES: Recent animal models of restless legs syndrome (RLS) suggest that brain iron deficiency is associated with a hypoadenosinergic state, with downregulation of adenosine A1 receptors (A1R) in the striatum and cortex. We hypothesized that an increase in extracellular adenosine induced by inhibitors of adenosine transporters, such as the non-selective ENT1/ENT2 inhibitor dipyridamole, would result in an improvement in RLS symptoms. METHODS: In a prospective two-month open-label, non-placebo controlled clinical trial, 15 untreated idiopathic RLS patients began treatment with 100 mg dipyridamole (with uptitration to 400 mg if necessary)...
May 2018: Sleep Medicine
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