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"Renal function" children

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https://www.readbyqxmd.com/read/28081313/clinical-and-histopathological-features-of-asymptomaticpersistent-microscopic-hematuria-in-children
#1
Serçin Güven, İbrahim Gökçe, Neslihan Çiçek Deniz, Ülger Altuntaş, Nurdan Yıldız, Harika Alpay
BACKGROUND/AIM: We analyzed the clinical and pathological features and prognosis of 106 children with persistent asymptomatic microscopic hematuria (PAMH) with or without mild proteinuria. MATERIALS AND METHODS: This was a retrospective study of 106 children who were referred to our clinics from 2000 to 2013 for evaluation of PAMH. RESULTS: Among the 106 patients, 69 (65%) were female and 37 (35%) were male. The patients were divided into two groups: 101 patients with isolated microscopic hematuria (IMH) and 5 patients with asymptomatic microscopic hematuria and mild proteinuria (AMHP)...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28063884/bilateral-wilms-tumor-with-ureteral-extension
#2
Gina Lockwood, Fernando Ferrer, John Makari
Wilms tumor is the most common renal tumor in children. However, tumor extension into the ureter is exceedingly rare. We present a case of bilateral Wilms tumor with unilateral ureteral extension into the bladder. This case illustrates the importance of thoughtful diagnostic evaluation and surgical planning to obtain a good oncologic outcome while preserving renal function.
January 4, 2017: Urology
https://www.readbyqxmd.com/read/28062909/paediatric-anti-neutrophil-cytoplasmic-antibody-anca-associated-vasculitis-an-update-on-renal-management
#3
REVIEW
Lucy A Plumb, Louise Oni, Stephen D Marks, Kjell Tullus
The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are a group of disorders characterized by necrotizing inflammation of the small to medium vessels in association with autoantibodies against the cytoplasmic region of the neutrophil. Included in this definition are granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (formerly known as Churg-Strauss syndrome). AAV are chronic, often relapsing diseases that can be organ or life threatening...
January 6, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28012005/primary-non-surgical-management-of-unilateral-ureteropelvic-junction-obstruction-in-children-a-systematic-review
#4
REVIEW
Marcus Weitz, Maria Schmidt, Guido Laube
Ureteropelvic junction obstruction (UPJO) is the most common obstructive uropathy and its optimal management remains controversial. However, there is a current trend towards non-surgical management. We aimed to determine the effects of the non-surgical management in children with unilateral UPJO. For a systematic review, we searched MEDLINE, EMBASE, CENTRAL, clinical trials registries, and selected conference proceedings for eligible studies. Any type of study reporting the outcomes renal function, secondary surgical intervention, drainage pattern or hydronephrosis of non-surgical management in children with unilateral UPJO was included...
December 23, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27999040/population-pharmacokinetics-of-cefazolin-before-during-and-after-cardiopulmonary-bypass-to-optimize-dosing-regimens-for-children-undergoing-cardiac-surgery
#5
Pieter A J G De Cock, Hussain Mulla, Sarah Desmet, Filip De Somer, Brett C McWhinney, Jacobus P J Ungerer, Annelies Moerman, Sabrina Commeyne, Johan Vande Walle, Katrien Francois, Johan G C Van Hasselt, Peter De Paepe
OBJECTIVES: The objective of this study was to characterize cefazolin serum pharmacokinetics in children before, during and after cardiopulmonary bypass (CPB), in order to derive an evidence-based dosing regimen. PATIENTS AND METHODS: This study included children who received cefazolin before surgical incision, before cessation of CPB and after surgery. Blood samples of total and unbound cefazolin concentrations were collected before, during and after CPB. The cefazolin concentration-time profiles were analysed using population pharmacokinetic modelling and predictors for interindividual variability in pharmacokinetic parameters were investigated...
December 20, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27988909/estimation-of-the-relationship-between-the-polymorphisms-of-selected-genes-ace-agtr1-tgf%C3%AE-1-and-gnb3-with-the-occurrence-of-primary-vesicoureteral-reflux
#6
Marcin Życzkowski, Joanna Żywiec, Krzysztof Nowakowski, Andrzej Paradysz, Władyslaw Grzeszczak, Janusz Gumprecht
PURPOSE: Etiopathogenesis of VUR is composite and not fully understood. Many data indicate the importance of genetic predisposition. The aim of this study was to establish the relationship of selected polymorphisms: 14094 polymorphism of the ACE, polymorphism rs1800469 of TGFβ-1, rs5443 gene polymorphism of the GNB3 and receptor gene polymorphism rs5186 type 1 AGTR1 with the occurrence of the primary vesicoureteral reflux. MATERIAL: The study included 190 children: 90 with the primary VUR confirmed with the voiding cystourethrogram and excluded secondary VUR and a control group of 100 children without a history of the diseases of the genitourinary tract...
December 17, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27982687/angiotensinogen-and-interleukin-18-as-markers-of-chronic-kidney-damage-in-children-with-a-history-of-hemolytic-uremic-syndrome
#7
K Lipiec, P Adamczyk, E Świętochowska, K Ziora, M Szczepańska
Hemolytic uremic syndrome (HUS) is a type of thrombotic microangiopathy, in the course of which some patients may develop chronic kidney disease (CKD). It is clinically important to investigate the markers of a poor prognosis. The levels of angiotensinogen (AGT) and interleukin-18 (IL-18) in serum and urine were evaluated. Study was conducted in 29 children with a history of HUS. Serum and urine AGT concentration was significantly higher in children after HUS as compared to the control group. No differences depending on the type of HUS and gender were noted...
December 16, 2016: Physiological Research
https://www.readbyqxmd.com/read/27977550/evaluation-of-teicoplanin-trough-values-following-the-recommended-loading-dose-in-children-with-associated-safety-analysis
#8
Takaaki Yamada, Toshio Kubota, Mahoro Yonezawa, Hisanori Nishio, Shunsuke Kanno, Takahisa Yano, Daisuke Kobayashi, Nobuaki Egashira, Hidetoshi Takada, Toshiro Hara, Satohiro Masuda
BACKGROUND: This study evaluated whether the recommended teicoplanin loading dose (three loading doses of 10 mg/kg every 12 h) achieves a 15-30 μg/mL trough levels in 26 children (2-16 years). In addition, we examined the incidences of renal impairment and hepatic dysfunction in children treated with teicoplanin. METHODS: This retrospective study was conducted between October 2008 and March 2014. RESULTS: The percentage of patients with a trough level <10 μg/mL and <15 μg/mL were 15...
December 12, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27975208/-renal-decapsulation-for-the-treatment-of-anuria-a-forgotten-treatment-from-the-early-20th-century
#9
D L Dräger, C Protzel, O W Hakenberg
In the early 20th century, Harrison first performed renal decapsulation in anuric children with scarlet fever and observed improvement in renal function postoperatively. The pathophysiological explanation was seen in intraparenchymal renal pressure due to edema which was improved by surgical decapsulation. The technique of decapsulation was simple excision after incision and blunt dissection of the renal parenchyma. Renal decapsulation then became a procedure commonly used for many indications in inflammatory renal conditions; indications were renal angioneurosis, hydronephrosis, toxic, bacterial and chronic nephritis, renal abscess and even eclampsia...
December 14, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27966809/delayed-elimination-of-high-dose-methotrexate-and-use-of-carboxypeptidase-g2-in-pediatric-patients-during-treatment-for-acute-lymphoblastic-leukemia
#10
Thommy Svahn, Karin Mellgren, Arja Harila-Saari, Ann Åsberg, Jukka Kanerva, Ólafur Jónsson, Goda Vaitkeviciene, Torben Stamm Mikkelssen, Kjeld Schmiegelow, Jesper Heldrup
BACKGROUND: Carboxypeptidase G2 (CPDG2 ) can be used as rescue treatment in cases of delayed methotrexate elimination (DME) and Mtx-induced nephrotoxicity. PROCEDURE: Between July 2008 and December 2014, all children (1.0-17.9 years) in the Nordic countries diagnosed with Philadelphia chromosome negative acute lymphoblastic leukemia (ALL) were treated according to the Nordic Organization for Pediatric Hematology and Oncology (NOPHO) ALL 2008 protocol, including administration of six to eight high-dose (5 g/m(2) /24 hr) Mtx (HDMtx) courses...
December 14, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27933438/acoustic-radiation-force-impulse-arfi-elastography-in-the-evaluation-of-renal-parenchymal-stiffness-in-patients-with-ureteropelvic-junction-obstruction
#11
Hatice Arioz Habibi, Rumeysa Yasemin Cicek, Sedat Giray Kandemirli, Emel Ure, Ayse Kalyoncu Ucar, Mine Aslan, Salim Caliskan, Ibrahim Adaletli
PURPOSE: To investigate the role of acoustic radiation force impulse (ARFI) elastography in the detection of renal parenchymal damage in kidneys with and without ureteropelvic junction obstruction (UPJO). METHODS: Twenty-five pediatric patients with a diagnosis of UPJO who underwent surgery and 15 pediatric patients with conservatively managed UPJO were prospectively evaluated with ARFI elastography. Sixteen healthy volunteers constituted the control group. Shear wave velocity (SWV) measurements in the upper, mid, and lower poles of the affected kidney were performed...
December 8, 2016: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27932102/kidney-transplantation-results-in-very-highly-sensitized-patients-included-in-a-virtual-crossmatch-program-analysis-of-kidney-pairs
#12
A Mazuecos, A Alvarez, A Nieto, M A Gentil, M Cabello, A Rodriguez-Benot, C Gracia, F Gonzalez, P Castro, M Alonso
BACKGROUND: Kidney transplantation in highly-sensitized (HS) patients can improve with organ-exchange strategies based on virtual crossmatch (V-XM). Experience in very-HS patients is limited. METHODS: In June 2012, Andalusia started a V-XM protocol for very-HS patients (calculated panel reactive antibodies ≥95%). After organ allocation a cytotoxic-XM performed immediately before transplantation had to be negative for surgery to proceed. We analyzed results up until December 2015...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27928430/optimal-treatment-of-tuberous-sclerosis-complex-associated-renal-angiomyolipomata-a-systematic-review
#13
REVIEW
John J Bissler, John C Kingswood
Renal angiomyolipomata associated with tuberous sclerosis complex are often bilateral, multiple and progressive. They cause significant morbidity and mortality in older children and adults. Surveillance and pre-emptive treatment reduce this risk. Recent research suggests treatment with mammalian target of rapamycin inhibitors is better at preventing bleeding, recurrence, and preserving renal function than percutaneous embolization.
August 2016: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/27916713/prognostic-value-of-ultrasound-grading-systems-in-prenatally-diagnosed-unilateral-urinary-tract-dilatation
#14
Aurélien Scalabre, Delphine Demède, Ségolène Gaillard, Jean-Pierre Pracros, Pierre Mouriquand, Pierre-Yves Mure
PURPOSE: We compared the prognostic value of anteroposterior intrasinus diameter of the renal pelvis, urinary tract dilatation and the Society for Fetal Urology grading system in children with prenatally diagnosed unilateral urinary tract dilatation. MATERIALS AND METHODS: All newborns with prenatally diagnosed unilateral urinary tract dilatation, normal bladder and anteroposterior intrasinus diameter 10 mm or greater on the first postnatal ultrasonography were prospectively enrolled from January 2011 to February 2015...
December 1, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27900958/renal-shear-wave-velocity-and-estimated-glomerular-filtration-rate-in-children-with-chronic-kidney-disease
#15
Costanza Bruno, Milena Brugnara, Rocco Micciolo, Mariangela Cecchetto, Michele Zuffante, Alessandra Bucci, Marco Zaffanello
A shear wave velocity (SWV) value obtained by the acoustic radiation force impulse technique depends on tissue elasticity. We investigated the relationship between SWV values and the estimated glomerular filtration rate (eGFR) in children with chronic kidney disease. A total of 29 patients were enrolled in the study. There were 18 primary and 11 secondary cases of vesicoureteral reflux. eGFR was calculated using Schwartz's formulas (2012). Partial eGFR for each kidney was assessed by multiplying the eGFR by the percentage of renal function measured by means of renal (99m)Tc-dimercaptosuccinic acid scintigraphy...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27894119/trajectories-and-predictors-of-allograft-dysfunction-after-renal-transplantation-in-children
#16
Vandréa Carla de Souza, Muriel Rabilloud, Pierre Cochat, Mario Bernardes Wagner, Clotilde Druck Garcia, Bruno Ranchin, Jean Iwaz, Luciano Selistre, Laurence Dubourg
BACKGROUND: The survival rates of renal transplant children are indeed on the rise, but it is still important to ensure that there is optimal renal function in these children in all their future growing years. The number of functioning nephrons and the graft ability to adapt to an increasing demand during body growth seem to be the most important factors for long-term allograft function. This study examined the long-term change in the glomerular filtration rate in a pediatric kidney transplant cohort and the importance of the recipient and donor ages in predicting transplant outcome...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/27890681/continent-anal-urinary-diversion-in-classic-bladder-exstrophy-45-year-experience
#17
Peter C Rubenwolf, Christian Hampel, Frederik Roos, Raimund Stein, Sebastian Frees, Joachim W Thüroff, Christian Thomas
OBJECTIVE: To evaluate the long-term outcomes in patients with classic bladder exstrophy and continent anal urinary diversion (CAD) for continence, upper urinary tract status, secondary malignancies, and sexual function. PATIENTS AND METHODS: The medical records of 82 exstrophy patients having undergone CAD in our department between 1970 and 2015 were reviewed. Patients were invited for follow-up examinations and asked to complete validated questionnaires relating to sexual function...
November 24, 2016: Urology
https://www.readbyqxmd.com/read/27878110/discontinuation-of-antimicrobial-prophylaxis-ap-in-children-with-spina-bifida-a-case-series-analysis
#18
Kevin G Couloures, Michael Anderson, Michael Machiorlatti, Olivera Marsenic, Lawrence Opas
BACKGROUND: Spina bifida increases the risk for urinary tract infections (UTI). Antimicrobial prophylaxis (AP) reduces symptomatic UTI's but selects resistant organisms. Measures to ensure regular and complete emptying of the bladder combined with treatment of constipation reduce the risk for UTI. OBJECTIVES: Demonstrate that close adherence to a catheterization regimen in children with spina bifida (Selective Treatment - ST) reduces the need for antimicrobial prophylaxis...
September 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27877096/a-prospective-pilot-study-on-the-systemic-absorption-of-oral-vancomycin-in-children-with-colitis
#19
James W Antoon, Margaret Hall, Diana Metropulos, Michael J Steiner, Ravi Jhaveri, Jacob A Lohr
BACKGROUND: Oral vancomycin is used to treat refractory colitis due to Clostridium dificile infection. Traditionally, oral vancomycin was thought to not be absorbed systemically, but recent adult studies have demonstrated detectable serum levels in over half of patients with severe colitis. This has not been studied in children. OBJECTIVE: To determine the absorption of oral vancomycin and the renal safety profile of oral vancomycin in children hospitalized with colitis. METHODS: We performed a prospective, observational, pilot proof of principle study at the North Carolina Children's Hospital in patients 2 years to 18 years of age receiving oral vancomycin for the treatment of C dificile colitis...
September 2016: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/27867847/retroperitoneal-and-laparoscopic-heminephrectomy-in-duplex-kidney-in-infants-and-children
#20
Ciro Esposito, Maria Escolino, Marco Castagnetti, Antonio Savanelli, Angela La Manna, Alessandra Farina, Francesco Turrà, Agnese Roberti, Alessandro Settimi, Francois Varlet, Holger Till, Jean Stephan Valla
BACKGROUND: Two main techniques are adopted to perform partial nephrectomy in children: laparoscopy and retroperitoneoscopy. The aim of this paper is to review the larger multicentric experience recently published by our group to review indications, techniques and results of both approaches. METHODS: Data of 102 patients underwent partial nephrectomy in a 5-year period using minimally invasive surgery (MIS) procedures were analyzed. Fifty-two children underwent laparoscopic partial nephrectomy (LPN), and 50 children underwent retroperitoneoscopic partial nephrectomy (RPN)...
October 2016: Translational pediatrics
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