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Contact derm

Agnieszka Jankowska, Sławomir Czerczak, Małgorzata Kupczewska-Dobecka
Assessment of dermal exposure to chemicals in the work environment is problematic, mainly as a result of the lack of measurement data on occupational exposure to chemicals. Due to common prevalence of occupational skin exposure and its health consequences it is necessary to look for efficient solutions allowing for reliable exposure assessment. The aim of the study is to present predictive models used to assess non-measured dermal exposure, as well as to acquaint Polish users with the principles of the selected model functioning...
June 27, 2017: Medycyna Pracy
Muhammad Saleem, Javed Iqbal, Munir H Shah
The present study is carried out for the assessment of water quality parameters and selected metals levels in surface water from Mangla Lake, Pakistan. The metal levels (Ca, Cd, Co, Cr, Cu, Fe, K, Li, Mg, Mn, Na, Ni, Pb, Sr, and Zn) were determined by flame atomic absorption spectrophotometry. Average levels of Cd, Co, Cr, Ni, and Pb were higher than the allowable concentrations set by national and international agencies. Principal component analysis indicated significant anthropogenic contributions of Cd, Co, Cr, Ni, and Pb in the water reservoir...
2014: TheScientificWorldJournal
Senada Hajdarevic, Asa Hörnsten, Elisabet Sundbom, Ulf Isaksson, Marcus Schmitt-Egenolf
We aimed to describe and compare patients diagnosed with malignant melanoma (MM), depending on their initial contact with care and with regard to age, sex, and MM type and thickness, and to explore pathways and time intervals (lead times) between clinics from the initial contact to diagnosis and treatment. The sample from northern Sweden was identified via the Swedish melanoma register. Data regarding pathways in health care were retrieved from patient records. In our unselected population of 71 people diagnosed with skin melanoma of SSM and NM types, 75% of patients were primarily treated by primary health-care centres (PHCs)...
2014: Dermatology Research and Practice
Tiffany Jow, Basil M Hantash
Melasma is an acquired cutaneous disorder caused by an overproduction of melanin by the enzyme tyrosinase. Melasma remains a therapeutic challenge and no definitive standard therapy exists. Although hydroquinone (HQ) has emerged as the most common treatment, its popularity has recently waned because of concerns about its potential carcinogenicity and manufacturing challenges. The adverse effects of HQ range from the common irritant contact dermatitis to the less frequent exogenous ochronosis (EO). Previous reports suggest that the risk of leukoderma from HQ treatment is limited to individuals of African descent...
January 2014: Dermatitis
D Trenti, D N Carlotti, D Pin, E Bensignor, O Toulza
OBJECTIVES: The aim of this study was to assess the clinical and aetiological aspects of contact dermatitis of the scrotum in dogs. METHODS: The medical records of 13 dogs with suspected scrotal contact dermatitis were retrospectively included in the study. For each case, historical findings, results of physical and dermatological examination and of avoidance tests as well as follow-up were included. Results of re-exposure tests and patch tests were also included when available...
June 2011: Journal of Small Animal Practice
Paul Damian
A health risk-based surface contamination cleanup standard (SCS) for beryllium (BE) was developed to facilitate the safe transfer of property (equipment and buildings) previously used in BE-related processes. Previous SCSs for BE were primarily based on Department of Energy (DOE) housekeeping criteria rather than health risks. Quantitative health risk assessment methods were used to develop an occupational SCS that explicitly considers the relevant exposure pathways and toxicity endpoints, including both cancer and non-cancer endpoints...
February 2011: Toxicology Mechanisms and Methods
Young Hee Sung, Ingak Kwon, Sungho Jo, Seungmi Park
PURPOSE: We sought to determine the type and incidence of ostomy-related complications and identify associated factors in Korean ostomy patients. METHODS: A retrospective analysis of medical records of 1,170 patients who underwent end colostomy in Samsung Medical Center between October 1994 and February 2005 was completed. Complications were classified as stomal or peristomal. Stomal complications included bleeding, necrosis, mucocutaneous separation, prolapsed stoma, retracted stoma, and stenosis...
March 2010: Journal of Wound, Ostomy, and Continence Nursing
Jacob Pontoppidan Thyssen, Howard Ira Maibach
An allergic dermatitis reaction may develop after systemic exposure to a hapten that reaches the skin through haematogenous transport. This condition can be observed with and without previous cutaneous sensitization to the hapten but has traditionally been described following topical exposure. A heterogeneous clinical picture, in combination with limited insight to its pathomechanisms, makes such systemic reactions an area in need of further study. This article summarizes knowledge about systemic dermatitis elicited by drugs, with a special emphasis on possible pathomechanisms...
October 2008: Contact Dermatitis
Jon M Hanifin
The eczemas represent a common and diverse group of inflammatory skin diseases whose definitions and pathogenic mechanisms have often been confused and controversial. Since the millennium, fresh approaches are providing better insight. Research has focused much more upon the epidermis and the very relevant signaling pathways that contribute to spongiosis, proliferation, generation of proinflammatory factors, and differentiation to form an effective stratum corneum barrier. A major step in understanding has come from the solidly confirmed association between filaggrin null mutations of ichthyosis vulgaris and atopic dermatitis...
February 2009: Journal of Investigative Dermatology
Pierre Effa, Achille Massougbodji, Francine Ntoumi, François Hirsch, Henri Debois, Marissa Vicari, Assetou Derme, Jacques Ndemanga-Kamoune, Joseph Nguembo, Benido Impouma, Jean-Paul Akué, Armand Ehouman, Alioune Dieye, Wen Kilama
The involvement of developing countries in international clinical trials is necessary for the development of appropriate medicines for local populations. However, the absence of appropriate structures for ethical review represents a barrier for certain countries. Currently there is very little information available on existing structures dedicated to ethics in western and central Africa. This article briefly describes historical milestones in the development of networks dedicated to capacity building in ethical review in these regions and outlines the major conclusions of two workshops on this issue, which were held in September and October 2002 in Libreville, Gabon, and Paris, France...
December 2007: Developing World Bioethics
Wouter Fransman, Roel Vermeulen, Hans Kromhout
OBJECTIVES: To determine levels of potential and actual dermal exposure to cyclophosphamide (CP) during performance of oncology-related tasks in hospitals and to investigate the relationship with potential sources and surface contamination levels of CP. METHODS: Dermal exposure to CP was determined for tasks with potential exposure to CP: preparation of CP, decanting of patients' urine, washing of the patient, removal of bed sheets of treated patients and cleaning of patients' toilets on oncology wards...
June 2005: International Archives of Occupational and Environmental Health
Jasna Lipozencić, Dubravka Bobek, Jasminka Jakić-Razumović
Atopic dermatitis (AD) has cellular immunohistochemical features similar to those of allergic contact dermatitis (ACD) and there is plenty of evidence for T-cell activation in this disease. The involvement of CD30+ T cells in acute stages of atopic dermatitis might establish CD30 as a helpful marker in differentiating those two diseases. Tissue sections from the skin of 12 patients with active atopic dermatitis and 13 with allergic contact (nickel-induced) dermatitis were immunohistochemically analyzed for cell-surface antigens, including CD30, CD3, CD4, and CD45RO...
2003: Acta Dermatovenerologica Croatica: ADC
Milena Kataranovski, Lidija Kandolf-Sekulović, Ivica Milosavljević
BACKGROUND: Contact hypersensitivity (CHS) is a local inflammatory response of the skin following challenge of hapten-sensitized animals. It is the consequence of cell infiltration of derm and the release of inflammation mediators, among which Tumor necrosis factor-alpha (TNF-alpha) is one of the most important factors. The intensity of the inflammation could be quantified by ear swelling which is the classical manifestation of the reaction. This study was testing the working hypothesis that levels of TNF-alpha in skin organ culture medium should correlate with the intensity of CHS reaction measured in vivo by ear swelling assay, and with the density of dermal infiltrate in ear skin samples...
November 2002: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
L C Heffler, A-L Kastman, G Jacobsson Ekman, A Scheynius, J Fransson
BACKGROUND: We know little of the initial events during the sensitization phase of contact allergy in humans. Alopecia areata (AA), a disease of unknown pathogenesis characterized by patchy hair loss, may be treated by inducing contact allergy to diphenylcyclopropenone (DPC), later followed by its topical application. OBJECTIVES: To learn more about the initial events during sensitization in human skin, we studied the early events during induction of contact allergy to DPC in patients with AA...
August 2002: British Journal of Dermatology
I K Brenner, P N Shek, R J Shephard
Coaches and athletic team physicians have provided anecdotal information and case studies to support their beliefs that athletes may be unusually prone to illness during strenuous training or competition. Many athletes, in contrast, believe that physical activity improves their resistance to infectious disease. However, it is generally agreed that the stress of competition may make athletes temporarily more susceptible to infectious illness. A review of the literature shows that upper respiratory tract infections and skin infections are more prevalent in top level athletes than in the general population, particularly during periods of intensive training...
February 1994: Sports Medicine
J P Guillot, J F Gonnet, C Clément, J M Faccini
An evaluation was made of the different protocols recommended by the Association Française de Normalisation (AFNOR) for assessing the sensitizing potential of chemicals in the guinea-pig. The methods studied were those of Magnusson & Kligman (J. invest. Derm. 1969, 52, 268), Maguire (J. Soc. cosmet. Chem. 1973, 24, 151), Maurer et al. (Agents & Actions 1975, 5, 174), Klecak et al. (J. Soc. cosmet. Chem. 1977, 28, 53), Dossou & Sicard (1984, to be published) and a hitherto unpublished method of Guillot, Gonnet, Clément & Brulos...
December 1983: Food and Chemical Toxicology
L V Shiliaeva
Dynamics of changes of intercellular contacts in the mouse spine epidermis have been studied in 1, 3, 5, 7, 10 days after its traumatic lesion performed up to the upper level of the papillary layer of the derm. In one day a complete desintegration of basal keratinocytes with some signs of reactive changes takes place. A partial desintegration is noted in the exfoliated spinous layer, which participates in the crust formation, as well as in formation of cells in marginal zones of the defect. When there is an intercellular edema, desmosomes manifest themselves as the most highly-adhesive junctions...
November 1984: Arkhiv Anatomii, Gistologii i émbriologii
A P Oranje, R S Aarsen, P G Mulder, G Liefaard
Forty children (0-5 years old), presented with immediate contact urticaria, rash and often atopic dermatitis (n = 34). Redness or urticaria around the mouth appearing after consuming cow's milk or egg, were the major complaints in all. These symptoms suggested a food-induced immediate contact reaction, which can be immune-mediated or irritative. To reinduce this reaction, a skin provocation test, called SAFT, was performed. SAFT stands for Skin Application Food Test. This test is based on direct skin contact, during a maximum of 30 min with food in its 'ordinary consumptive state'...
1991: Acta Dermato-venereologica
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