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https://www.readbyqxmd.com/read/29792212/the-role-of-human-metapneumovirus-genetic-diversity-and-nasopharyngeal-viral-load-on-symptom-severity-in-adults
#1
Xiang Yong Oong, Jack Bee Chook, Kim Tien Ng, Wei Zhen Chow, Kok Gan Chan, Nik Sherina Hanafi, Yong Kek Pang, Yoke Fun Chan, Adeeba Kamarulzaman, Kok Keng Tee
BACKGROUND: Human metapneumovirus (HMPV) is established as one of the causative agents of respiratory tract infections. To date, there are limited reports that describe the effect of HMPV genotypes and/or viral load on disease pathogenesis in adults. This study aims to determine the role of HMPV genetic diversity and nasopharyngeal viral load on symptom severity in outpatient adults with acute respiratory tract infections. METHODS: Severity of common cold symptoms of patients from a teaching hospital was assessed by a four-category scale and summed to obtain the total symptom severity score (TSSS)...
May 23, 2018: Virology Journal
https://www.readbyqxmd.com/read/29785605/selection-of-inactivation-medium-for-fungal-spores-in-clinical-wastes-by-supercritical-carbon-dioxide
#2
Efaq Noman, Nik Norulaini Nik Ab Rahman, Adel Al-Gheethi, Hideyuki Nagao, Balkis A Talip, Omar Ab Kadir
The present study aimed to select the best medium for inactivation of Aspergillus fumigatus, Aspergillus spp. in section Nigri, A. niger, A. terreus var. terreus, A. tubingensis, Penicillium waksmanii, P. simplicissimum, and Aspergillus sp. strain no. 145 spores in clinical wastes by using supercritical carbon dioxide (SC-CO2 ). There were three types of solutions used including normal saline, seawater, distilled water, and physiological saline with 1% of methanol; each solution was tested at 5, 10, and 20 mL of the water contents...
May 21, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29781170/a-national-point-of-care-ultrasound-competition-for-medical-students
#3
Creagh Boulger, Rachel B Liu, Giuliano De Portu, Nik Theyyunni, Margaret Lewis, Resa E Lewiss, Zachary P Soucy, Vi Am Dinh, Alan Chiem, Sara Singhal, Donald Di Salvo, John S Pellerito, David Bahner
No abstract text is available yet for this article.
May 21, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29778280/influence-of-cataract-surgery-on-meibomian-gland-dysfunction
#4
A El Ameen, S Majzoub, G Vandermeer, P-J Pisella
PURPOSE: To evaluate the influence of cataract surgery on Meibomian gland dysfunction, in particular on postoperative functional symptoms. PATIENTS AND METHODS: Thirty patients who underwent cataract surgery were included in the study. A clinical examination (OSDI questionnaire, measurement of tear break-up time (TBUT), corneal staining, Meibomian gland expression test) and a paraclinical evaluation (Meibomian gland loss [MGL] measured using ImageJ on Meibography, conjunctival hyperemia and non-invasive keratograph break-up time [NIK-BUT]) were performed preoperatively and at 1month and 3months after phacoemulsification...
May 16, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29777556/electrophysiology-and-structural-interventions-in-adults-with-congenital-heart-disease-comparison-of-combined-versus-separate-procedures
#5
Ian Lindsay, Farnoosh Nik-Ahd, Jamil A Aboulhosn, Jeremy P Moore
BACKGROUND: Electrophysiologic (EP) and structural interventions in adult congenital heart disease (ACHD) are typically completed during separate hospital encounters. With planning/coordination, these cases can be combined. OBJECTIVES: We hypothesized that this integrated approach would yield patient and health system benefits. METHODS: Consecutive ACHD patients undergoing combined interventions were matched to controls with identical but separate procedures...
May 18, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29767614/differential-attenuation-of-marek-s-disease-virus-induced-tumours-and-late-marek-s-disease-virus-induced-immunosuppression
#6
Nik M Faiz, Aneg L Cortes, James S Guy, Sanjay M Reddy, Isabel M Gimeno
Marek's disease virus (MDV) is a herpesvirus that induces lymphoma and a variety of non-neoplastic syndromes in chickens. Furthermore, very virulent plus (vv+) MDVs induce a form of immunosuppression (late-MDV-IS) that might involve both neoplastic and non-neoplastic mechanisms. The objective of this study was to evaluate whether the attenuation of MDV-induced tumours and late-MDV-IS occurs simultaneously or can be dissociated. The immunosuppressive ability of three viruses derived from vv+ MDV strain 686 (wild-type 686, the somewhat attenuated molecular clone 686-BAC, and the nononcogenic molecular clone lacking the two copies of the oncogene meq 686-BACΔMEQ) was evaluated...
May 16, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29759775/real-time-x-mri-guided-left-ventricular-lead-implantation-for-targeted-delivery-of-cardiac-resynchronization-therapy
#7
Jonathan M Behar, Peter Mountney, Daniel Toth, Sabrina Reiml, Maria Panayiotou, Alexander Brost, Bernhard Fahn, Rashed Karim, Simon Claridge, Tom Jackson, Ben Sieniewicz, Nik Patel, Mark O'Neill, Reza Razavi, Kawal Rhode, Christopher Aldo Rinaldi
OBJECTIVES: This study sought to test the feasibility of a purpose-built, integrated software platform to process, analyze, and overlay cardiac magnetic resonance (CMR) data in real time within a combined cardiac catheter laboratory and magnetic resonance imaging scanner suite (X-MRI) to guide left ventricular (LV) lead implantation. BACKGROUND: Suboptimal LV lead position is a major determinant of poor cardiac resynchronization therapy (CRT) response, and the optimal site is highly patient specific...
August 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29748608/hepatic-steatosis-associated-with-decreased-%C3%AE-oxidation-and-mitochondrial-function-contributes-to-cell-damage-in-obese-mice-after-thermal-injury
#8
Li Diao, Christopher Auger, Hisato Konoeda, Ali-Reza Sadri, Saeid Amini-Nik, Marc G Jeschke
Severely burned patients who are morbidly obese have poor clinical outcomes with aggravated metabolic consequences, a higher incidence of multiple organ dysfunction/failure, and significantly increased morbidity and mortality. The underlying mechanisms of these adverse outcomes are essentially unknown. Since the liver is one of the central metabolic organs, we hypothesized that thermal injury in obese patients leads to substantially increased lipolysis, hepatic fat infiltration, resulting in profound hepatic cellular and organellar alterations, consequently causing liver damage and severely augmented metabolic dysfunction...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29728424/the-non-canonical-nf-%C3%AE%C2%BAb-pathway-and-its-contribution-to-%C3%AE-cell-failure-in-diabetes
#9
Kira Meyerovich, Fernanda Ortis, Alessandra K Cardozo
The prevalence of diabetes has reached 8.8% in worldwide population and is predicted to increase up to 10,4% by 2040. Thus, there is an urgent need for the development of means to treat or prevent this major disease. Due to its role in inflammatory responses, several studies demonstrated the importance of the transcription factor NF-κB in both type 1 (T1D) and type 2 diabetes (T2D). The two major NF-κB pathways are the canonical and the non-canonical. The later pathway is activated by the NF-κB-Inducing Kinase (NIK) that triggers p100 processing into p52, which forms with RelB its main dimer...
May 4, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29726893/the-effect-of-vitamin-d-on-intestinal-inflammation-and-faecal-microbiota-in-patients-with-ulcerative-colitis
#10
Mayur Garg, Philip Hendy, John Nik Ding, Sophie Shaw, Georgina Hold, Ailsa Hart
Background and Aims: There is evidence vitamin D may be immunomodulatory and alter faecal microbiota, but results from clinical studies in humans to date have been inconclusive. This study aimed to assess the effect of vitamin D replacement in vitamin D deficient patients with and without ulcerative colitis (UC) on inflammation and faecal microbiota. Methods: Vitamin D was replaced over 8 weeks in patients with active UC (defined by faecal calprotectin ≥100 µg/g), inactive UC (faecal calprotectin <100 µg/g), and non-IBD controls with baseline 25(OH) vitamin D <50 nmol/L, and markers of inflammation and faecal microbiota analysed...
May 3, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29719845/the-efficacy-of-glasgow-coma-scale-gcs-score-and-acute-physiology-and-chronic-health-evaluation-apache-ii-for-predicting-hospital-mortality-of-icu-patients-with-acute-traumatic-brain-injury
#11
Amir Nik, Mohammad Sobhan Sheikh Andalibi, Mohammad Reza Ehsaei, Ahmadreza Zarifian, Ehsan Ghayoor Karimiani, Gholamreza Bahadoorkhan
Objective: To compare the efficacy and functional outcome of Glasgow Coma Scale (GCS) score with that of Acute Physiology and Chronic Health Evaluation Score II (APACHE II) in patients with multiple trauma admitted to the ICU. Methods: This cross-sectional study included 125 patients with traumatic brain injury associated with systemic trauma admitted to the ICU of Shahid Kamyab Hospital, Mashhad, between September 2015 and December 2016. On the day of admission, data were collected from each patient to calculate GCS and APACHE II scores...
April 2018: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/29717121/validating-the-concept-of-mutational-signatures-with-isogenic-cell-models
#12
Xueqing Zou, Michel Owusu, Rebecca Harris, Stephen P Jackson, Joanna I Loizou, Serena Nik-Zainal
The diversity of somatic mutations in human cancers can be decomposed into individual mutational signatures, patterns of mutagenesis that arise because of DNA damage and DNA repair processes that have occurred in cells as they evolved towards malignancy. Correlations between mutational signatures and environmental exposures, enzymatic activities and genetic defects have been described, but human cancers are not ideal experimental systems-the exposures to different mutational processes in a patient's lifetime are uncontrolled and any relationships observed can only be described as an association...
May 1, 2018: Nature Communications
https://www.readbyqxmd.com/read/29716577/is-adolescent-body-mass-index-and-waist-circumference-associated-with-the-food-environments-surrounding-schools-and-homes-a-longitudinal-analysis
#13
Mark A Green, Duncan Radley, Nik Lomax, Michelle A Morris, Claire Griffiths
BACKGROUND: There has been considerable interest in the role of access to unhealthy food options as a determinant of weight status. There is conflict across the literature as to the existence of such an association, partly due to the dominance of cross-sectional study designs and inconsistent definitions of the food environment. The aim of our study is to use longitudinal data to examine if features of the food environment are associated to measures of adolescent weight status. METHODS: Data were collected from secondary schools in Leeds (UK) and included measurements at school years 7 (ages 11/12), 9 (13/14), and 11 (15/16)...
May 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29695633/astx660-a-novel-non-peptidomimetic-antagonist-of-ciap1-2-and-xiap-potently-induces-tnf-%C3%AE-dependent-apoptosis-in-cancer-cell-lines-and-inhibits-tumor-growth
#14
George A Ward, Edward J Lewis, Jong Sook Ahn, Christopher N Johnson, John F Lyons, Vanessa Martins, Joanne M Munck, Sharna J Rich, Tomoko Smyth, Neil T Thompson, Pamela A Williams, Nicola E Wilsher, Nicola G Wallis, Gianni Chessari
Due to their roles in the evasion of apoptosis, Inhibitor of Apoptosis Proteins (IAPs) are considered attractive targets for anti-cancer therapy. Antagonists of these proteins have the potential to switch pro-survival signaling pathways in cancer cells towards cell death. Various SMAC-peptidomimetics with inherent cIAP selectivity have been tested clinically and demonstrated minimal single agent efficacy. ASTX660 is a potent, non-peptidomimetic, antagonist of cIAP1/2 and XIAP, discovered using fragment-based drug design...
April 25, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29694377/a-framework-for-the-estimation-of-the-proportion-of-true-discoveries-in-single-nucleotide-variant-detection-studies-for-human-data
#15
Nik Tuzov
Any single nucleotide variant detection study could benefit from a fast and cheap method of measuring the quality of variant call list. It is advantageous to be able to see how the call list quality is affected by different variant filtering thresholds and other adjustments to the study parameters. Here we look into a possibility of estimating the proportion of true positives in a single nucleotide variant call list for human data. Using whole-exome and whole-genome gold standard data sets for training, we focus on building a generic model that only relies on information available from any variant caller...
2018: PloS One
https://www.readbyqxmd.com/read/29683079/the-link-between-domestic-violence-and-abuse-and-animal-cruelty-in-the-intimate-relationships-of-people-of-diverse-genders-and-or-sexualities-a-binational-study
#16
Damien W Riggs, Nik Taylor, Heather Fraser, Catherine Donovan, Tania Signal
Over the past three decades, a growing body of research has focused on experiences of domestic violence and abuse (DVA) among people of diverse genders and/or sexualities. Missing, however, has been a focus on what is known as "the link" between DVA and animal cruelty with regard to people of diverse genders and/or sexualities. The present article reports on a study of 503 people living in either Australia or the United Kingdom, who reported on both their intimate human relationships and their relationships with animals, including relationships that were abusive...
April 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29682908/tracking-disease-progression-non-invasively-in-duchenne-and-becker-muscular-dystrophies
#17
Pietro Spitali, Kristina Hettne, Roula Tsonaka, Mohammed Charrout, Janneke van den Bergen, Zaïda Koeks, Hermien E Kan, Melissa T Hooijmans, Andreas Roos, Volker Straub, Francesco Muntoni, Cristina Al-Khalili-Szigyarto, Marleen J A Koel-Simmelink, Charlotte E Teunissen, Hanns Lochmüller, Erik H Niks, Annemieke Aartsma-Rus
BACKGROUND: Analysis of muscle biopsies allowed to characterize the pathophysiological changes of Duchenne and Becker muscular dystrophies (D/BMD) leading to the clinical phenotype. Muscle tissue is often investigated during interventional dose finding studies to show in situ proof of concept and pharmacodynamics effect of the tested drug. Less invasive readouts are needed to objectively monitor patients' health status, muscle quality, and response to treatment. The identification of serum biomarkers correlating with clinical function and able to anticipate functional scales is particularly needed for personalized patient management and to support drug development programs...
April 16, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29667646/leptospirosis-and-workplace-environmental-risk-factors-among-cattle-farmers-in-northeastern-malaysia
#18
Aziah Binti Daud, Nik Mohd Hafiz Mohd Fuzi, Wan Mohd Zahiruddin Wan Mohammad, Fairuz Amran, Nabilah Ismail, Mohd Mokhtar Arshad, Suratan Kamarudin
BACKGROUND: Leptospirosis is an emerging zoonosis and its occurrence has been reported to be rising globally. The environment plays an important role in the survival of Leptospira and determines the risk of infection. Those who were exposed to and had contact with contaminated environment through their occupational, recreational and other activities can be infected with the organism. OBJECTIVE: To determine the seroprevalence of leptospirosis among cattle farmers, prevalence of pathogenic Leptospira, and the workplace environmental risk factors for leptospirosis among cattle farmers in northeastern Malaysia...
April 2018: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29662977/handheld-skin-printer-in-situ-formation-of-planar-biomaterials-and-tissues
#19
Navid Hakimi, Richard Cheng, Lian Leng, Mohammad Sotoudehfar, Phoenix Qing Ba, Nazihah Bakhtyar, Saeid Amini-Nik, Marc G Jeschke, Axel Günther
We present a handheld skin printer that enables the in situ formation of biomaterial and skin tissue sheets of different homogeneous and architected compositions. When manually positioned above a target surface, the compact instrument (weight <0.8 kg) conformally deposits a biomaterial or tissue sheet from a microfluidic cartridge. Consistent sheet formation is achieved by coordinating the flow rates at which bioink and cross-linker solution are delivered, with the speed at which a pair of rollers actively translate the cartridge along the surface...
April 17, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29657684/traditional-and-complementary-medicine-use-in-knee-osteoarthritis-and-its-associated-factors-among-patients-in-northeast-peninsular-malaysia
#20
Nik Abdul Hafiz Nik Shafii, Lili Husniati Yaacob, Azlina Ishak, Azidah Abdul Kadir
Objectives: We sought to determine the prevalence of traditional and complementary medicine (TCM) use for knee osteoarthritis and its associated factors among patients attending a referral hospital in an eastern coastal state of Malaysia. Methods: This cross-sectional study included 214 patients with knee osteoarthritis. A universal sampling method was applied to patients who attended the outpatient clinic in Hospital Universiti Sains Malaysia from May 2013 to October 2013...
March 2018: Oman Medical Journal
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