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https://www.readbyqxmd.com/read/28749423/distinct-mechanisms-of-biotic-and-chemical-elicitors-enable-additive-elicitation-of-the-anticancer-phytoalexin-glyceollin-i
#1
Kelli Farrell, Md Asraful Jahan, Nik Kovinich
Phytoalexins are metabolites biosynthesized in plants in response to pathogen, environmental, and chemical stresses that often have potent bioactivities, rendering them promising for use as therapeutics or scaffolds for pharmaceutical development. Glyceollin I is an isoflavonoid phytoalexin from soybean that exhibits potent anticancer activities and is not economical to synthesize. Here, we tested a range of source tissues from soybean, in addition to chemical and biotic elicitors, to understand how to enhance the bioproduction of glyceollin I...
July 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28733569/a-case-of-missed-blunt-traumatic-aortic-injury-btai
#2
N M Nik Azlan, H Rossman
We are reporting a case of missed blunt traumatic aortic injury (BTAI). A 28 year male presented with chest pain following a motor vehicle accident. He was discharged following normal clinical signs and chest radiograph. The following day he complained of lower limb weakness. Traumatic aortic dissection was revealed via computer tomography (CT) of the thorax. BTAI cannot be ruled out with normal clinical signs and chest radiograph alone. CT thorax is mandatory to rule out BTAI in high impact chest injury.
June 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28732923/effect-of-tempo-oxidization-and-rapid-cooling-on-thermo-structural-properties-of-nanocellulose
#3
Mhd Abd Cader Mhd Haniffa, Yern Chee Ching, Cheng Hock Chuah, Kuan Yong Ching, Nik Nazri, Luqman Chuah Abdullah, Liou Nai-Shang
Recently, surface functionality and thermal property of the green nanomaterials have received wide attention in numerous applications. In this study, microcrystalline cellulose (MCC) was used to prepare the nanocrystalline celluloses (NCCs) using acid hydrolysis method. The NCCs was treated with TEMPO [(2,2,6,6-tetramethylpiperidin-1-yl)oxy radical]-oxidation to prepare TEMPO-oxidized NCCs. Cellulose nanofibrils (CNFs) also prepared from MCC using TEMPO-oxidation. The effects of rapid cooling and chemical treatments on the thermo-structural property studies of the prepared nanocelluloses were investigated through FTIR, thermogravimetric analysis-derivative thermogravimetric (TGA-DTG), and XRD...
October 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28719631/the-distribution-and-host-range-of-the-banana-fusarium-wilt-fungus-fusarium-oxysporum-f-sp-cubense-in-asia
#4
Diane Mostert, Agustin B Molina, Jeff Daniells, Gerda Fourie, Catur Hermanto, Chih-Ping Chao, Emily Fabregar, Vida G Sinohin, Nik Masdek, Raman Thangavelu, Chunyu Li, Ganyun Yi, Lizel Mostert, Altus Viljoen
Fusarium oxysporum formae specialis cubense (Foc) is a soil-borne fungus that causes Fusarium wilt, which is considered to be the most destructive disease of bananas. The fungus is believed to have evolved with its host in the Indo-Malayan region, and from there it was spread to other banana-growing areas with infected planting material. The diversity and distribution of Foc in Asia was investigated. A total of 594 F. oxysporum isolates collected in ten Asian countries were identified by vegetative compatibility groups (VCGs) analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28717329/statin-therapy-prescribing-for-patients-with-type-2-diabetes-mellitus-a-review-of-current-evidence-and-challenges
#5
REVIEW
Mohamed Hassan Elnaem, Mohamad Haniki Nik Mohamed, Hasniza Zaman Huri, Shah M Azarisman, Ramadan Mohamed Elkalmi
Use of statin therapy in patients with type 2 diabetes mellitus (T2DM) has been recommended by most clinical guidelines. Cardiovascular disease (CVD) is a leading cause of morbidity and mortality among T2DM patients. It has been proved that statins are effective for primary or secondary CVD prophylaxis. Reports have highlighted the underutilization of statins in clinical practice and the suboptimal adherence to guideline recommendations. This review article points to summarize the current evidence confirming the role of statins in T2DM patients and to provide an overview of factors that may affect statins' prescribing patterns and compliance in clinical practice...
April 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28702926/the-stability-evaluation-of-mesenchymal-stem-cells-differentiation-toward-endothelial-cells-by-chemical-and-mechanical-stimulation
#6
Elham Hasanzadeh, Ghassem Amoabediny, Nooshin Haghighipour, Nasim Gholami, Javad Mohammadnejad, Shahrokh Shojaei, Nasim Salehi-Nik
Adipose-derived mesenchymal stem cells (ADSCs) are adult multipotent cells able to differentiate into several cell lineages. Vascular endothelial growth factor (VEGF) and the shear stress associated with blood flow are considered as the most important chemical and mechanical cues that play major roles in endothelial differentiation. However, the stability of endothelial-specific gene expression has not been completely addressed yet. ADSCs in passage 3 were cultured inside the tubular silicon tubes and then exposed to VEGF or shear stress produced in a perfusion bioreactor...
July 12, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28681241/platelet-rna-signatures-for-the-detection-of-cancer
#7
Nik Sol, Thomas Wurdinger
Platelets are equipped with RNA processing machineries, such as pre-mRNA splicing, pre-miRNA processing, and mRNA translation. Since platelets are devoid of a nucleus, most RNA transcripts in platelets are derived from megakaryocytes during thrombocytogenesis. However, platelets can also ingest RNA molecules during circulation and/or interaction with other cell types. Since platelets were first described by Bizzozero in 1881, their well-established role in hemostasis and thrombosis has been intensively studied...
July 5, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28673445/does-injection-flow-rate-have-an-impact-on-arterial-phase-image-degradation-in-liver-mri-a-comparison-of-gadoxetic-acid-versus-gadobutrol
#8
V Cohen-Hallaleh, L Guo, H Hosseini-Nik, N Razaghi Kashani, R Menezes, K Jhaveri
AIM: To evaluate retrospectively the impact of injection flow rate on arterial phase image degradation in liver magnetic resonance imaging (MRI) with gadoxetic acid (Gd-EOB-DTPA) compared to gadobutrol. MATERIALS AND METHODS: Two hundred consecutive patients who had undergone liver MRI were enrolled in this Health Insurance Portability and Accountability Act (HIPAA)-compliant institutional review board (IRB)-approved study and were divided into three groups. Group 1 (50 patients) and 2 (50 patients) had undergone MRI performed with gadoxetic acid (fixed 10 ml) at flow rate of 1 and 2 ml/s, respectively...
June 30, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28672132/deficient-dorsalis-pedis-flow-in-severe-idiopathic-clubfeet-does-ponseti-casting-affect-the-outcome
#9
Ismail Munajat, Mehran Yoysefi, Nik Munirah Nik Mahdi
BACKGROUND: Arterial deficiency in congenital clubfoot or congenital talipes equinovarus (CTEV) was postulated as either the primary cause of deformity or secondary manifestation of other bony and soft tissue abnormalities. The objectives of the study were to find any association between arterial deficiency with severity of CTEV and its treatment. METHOD: This prospective study conducted on 24 feet with CTEV (18 babies) with Pirani score ranging between 2 to 6. Eighteen normal babies (36 feet) were selected as control...
June 8, 2017: Foot
https://www.readbyqxmd.com/read/28671559/thiolate-capped-cdse-zns-core-shell-quantum-dots-for-the-sensitive-detection-of-glucose
#10
Samsulida Abd Rahman, Nurhayati Ariffin, Nor Azah Yusof, Jaafar Abdullah, Faruq Mohammad, Zuhana Ahmad Zubir, Nik Mohd Azmi Nik Abd Aziz
A semiconducting water-soluble core-shell quantum dots (QDs) system capped with thiolated ligand was used in this study for the sensitive detection of glucose in aqueous samples. The QDs selected are of CdSe-coated ZnS and were prepared in house based on a hot injection technique. The formation of ZnS shell at the outer surface of CdSe core was made via a specific process namely, SILAR (successive ionic layer adsorption and reaction). The distribution, morphology, and optical characteristics of the prepared core-shell QDs were assessed by transmission electron microscopy (TEM) and spectrofluorescence, respectively...
July 1, 2017: Sensors
https://www.readbyqxmd.com/read/28666635/initial-outcomes-of-integrated-community-based-hepatitis-c-treatment-for-people-who-inject-drugs-findings-from-the-queensland-injectors-health-network
#11
Leith Morris, Andrew Smirnov, Amanda Kvassay, Ellen Leslie, Rebecca Kavanagh, Nik Alexander, Geoff Davey, Owain Williams, Charles Gilks, Jake Najman
BACKGROUND: Integrated treatment and harm reduction services provide a unique opportunity to facilitate direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV)-infected people who inject drugs (PWID). We examine outcomes of community-based delivery of DAA therapy for PWID. METHODS: The Queensland Injectors' Health Network (QuIHN) is a community-based agency providing harm reduction and treatment services. Data (including current injecting, involvement in opioid substitution therapy and other treatment, level of case management support) for participants initiating DAA therapy were collected...
June 27, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28656364/the-critical-role-of-macrophages-in-the-pathogenesis-of-hidradenitis-suppurativa
#12
REVIEW
Ahmed Shah, Raed Alhusayen, Saeid Amini-Nik
INTRODUCTION: Hidradenitis suppurativa (HS) is a painful chronic inflammatory disease with a prevalence between 1 and 4% of general population. The pathogenesis of HS long eluded scientists, but growing evidence suggests that it is a consequence of inflammatory dysregulation. FINDINGS: Recent studies suggest that dysregulated immune response to skin flora and overexpression of inflammatory cytokines leads to chronic skin inflammation seen in HS. Macrophages are the most numerous inflammatory cells found in HS infiltrates and release numerous pro-inflammatory cytokines such as IL-23, and IL-1β and TNF-α, exacerbating the inflammation and contributing to the pathogenesis of HS...
June 27, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28648745/batch-anaerobic-digestion-of-deproteinated-malt-whisky-pot-ale-using-different-source-inocula
#13
Raquel Barrena, Julio E Traub, Cristina Rodriguez Gil, Julian A S Goodwin, Alan J Harper, Nik A Willoughby, Antoni Sánchez, Thomas J Aspray
A novel process has been developed for the selective removal of protein from pot ale with recovered protein holding potential as a value-added by-product for the whisky industry. The purpose of this work was to assess the effect of deproteination on pot ale physicochemical characterisation and anaerobic digestion (AD) treatment. Pot ales were taken from five malt whisky distilleries and tested untreated, after centrifugation/filtration and after deproteination at laboratory or pilot scale. At laboratory scale, the deproteination process removed around 20% of total chemical oxygen demand (tCOD) from untreated pot ale and at least 30% dissolved copper from centrifuged pot ale...
June 22, 2017: Waste Management
https://www.readbyqxmd.com/read/28641524/the-bio-psycho-social-dimension-in-women-s-sexual-desire-argumentum-ad-novitatem
#14
Nur Syazwani Roslan, Nik Ruzyanei Nik Jaafar, Hatta Sidi, Najwa Baharuddin, Jaya Kumar, Srijit Das, Nik Hazlina Nik Hussein
Sexual desire includes complex motivation and drive. In the context of biological and cognitive-emotive state art of science, it is often a neglected field in medicine. With regard to the treatment, study on women's sexual function received less attention compared to the men's sexuality. In the past, this endeavor was relatively not well disseminated in the scientific community. Recently, there was a revolutionized surge of drug targets available to treat women with low sexual desire. It is timely to review the relevant biological approach, especially in the context of pharmacotherapy to understand this interesting clinical entity which was modulated by numerous interactive psychosocial inter-play and factors...
June 21, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28623356/high-risk-human-papillomavirus-e7-alters-host-dna-methylome-and-represses-hla-e-expression-in-human-keratinocytes
#15
Louis Cicchini, Rachel Z Blumhagen, Joseph A Westrich, Mallory E Myers, Cody J Warren, Charlotte Siska, David Raben, Katerina J Kechris, Dohun Pyeon
Human papillomavirus (HPV) infection distinctly alters methylation patterns in HPV-associated cancer. We have recently reported that HPV E7-dependent promoter hypermethylation leads to downregulation of the chemokine CXCL14 and suppression of antitumor immune responses. To investigate the extent of gene expression dysregulated by HPV E7-induced DNA methylation, we analyzed parallel global gene expression and DNA methylation using normal immortalized keratinocyte lines, NIKS, NIKS-16, NIKS-18, and NIKS-16∆E7...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619038/the-experiences-of-women-with-maternal-near-miss-and-their-perception-of-quality-of-care-in-kelantan-malaysia-a-qualitative-study
#16
Mohd Noor Norhayati, Nik Hussain Nik Hazlina, Ab Razak Asrenee, Zaharah Sulaiman
BACKGROUND: Maternal mortality has been the main way of ascertaining the outcome of maternal and obstetric care. However, maternal morbidities occur more frequently than maternal deaths; therefore, maternal near miss was suggested as a more useful indicator for the evaluation and improvement of maternal health services. Our study aimed to explore the experiences of women with maternal near miss and their perception of the quality of care in Kelantan, Malaysia. METHODS: A qualitative phenomenological approach with in-depth interview method was conducted in two tertiary hospitals in Kelantan, Malaysia...
June 15, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28607634/evaluation-of-the-diagnostic-value-of-serum-level-of-total-bilirubin-in-patients-with-suspected-acute-appendicitis
#17
Mohammad Reza Motie, Minoosadat Mousavi Nik, Malihe Gharaee
INTRODUCTION: Clinical diagnosis of acute appendicitis still remains a problem. Delays in diagnosis of acute appendicitis may cause perforation and septic peritonitis which result in increasing morbidity and mortality. The aim of this study was to determine the sensitivity, specificity and the diagnostic value of total serum bilirubin levels as a predictor of acute appendicitis. METHODS: In this cross-sectional study, patients who underwent appendectomy with the diagnosis of acute appendicitis from April 2012 to March 2013 at Emam Reza Hospital in Mashhad (Iran) were enrolled...
April 2017: Electronic Physician
https://www.readbyqxmd.com/read/28605330/effect-of-antihypertensive-drug-treatment-on-oxidative-stress-markers-in-heart-of-spontaneously-hypertensive-rat-models
#18
Nik Syamimi Nik Yusoff, Zulkarnain Mustapha, Sharifah Emilia Tuan Sharif, Chandran Govindasamy, Kuttulebbai Nainamohamed Salam Sirajudeen
Oxidative stress has been suggested to play a role in hypertension- and hypertension-induced organ damage. The effect of antihypertensive drug treatments on oxidative stress markers has not been well assessed. Therefore, in this study we investigated the effect of enalapril on oxidative stress markers in hearts of hypertensive rat models such as spontaneously hypertensive rats (SHR) and SHRs administered N-nitro-L-arginine methyl ester (SHR+L-NAME rats). Male rats were divided into four groups: SHRs, SHR+enalapril (SHR-E) rats, SHR+L-NAME rats, SHR+enalapril+L-NAME (SHRE+L-NAME) rats...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/28592158/phase-ib-study-of-the-mtor-inhibitor-everolimus-with-low-dose-cytarabine-in-elderly-acute-myeloid-leukemia
#19
Ing Soo Tiong, Peter Tan, Julie McManus, Nik Cummings, Sonali Sadawarte, John Catalano, Robert Hills, Andrew Wei
No abstract text is available yet for this article.
June 8, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28578506/first-international-consensus-conference-on-standardization-of-oncoplastic-breast-conserving-surgery
#20
Walter P Weber, Savas D Soysal, Mahmoud El-Tamer, Virgilio Sacchini, Michael Knauer, Christoph Tausch, Nik Hauser, Andreas Günthert, Yves Harder, Elisabeth A Kappos, Fabienne Schwab, Florian Fitzal, Peter Dubsky, Vesna Bjelic-Radisic, Roland Reitsamer, Rupert Koller, Jörg Heil, Markus Hahn, Jens-Uwe Blohmer, Jürgen Hoffmann, Christine Solbach, Christoph Heitmann, Bernd Gerber, Martin Haug, Christian Kurzeder
PURPOSE: To obtain consensus recommendations for the standardization of oncoplastic breast conserving surgery (OPS) from an international panel of experts in breast surgery including delegates from the German, Austrian and Swiss societies of senology. METHODS: A total of 52 questions were addressed by electronic voting. The panel's recommendations were put into context with current evidence and the report was circled in an iterative open email process until consensus was obtained...
June 3, 2017: Breast Cancer Research and Treatment
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