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https://www.readbyqxmd.com/read/29336591/adherence-to-antiretroviral-therapy-stigma-and-behavioral-risk-factors-in-hiv-infected-adolescents-in-asia
#1
Wasana Prasitsuebsai, Chuenkamol Sethaputra, Pagakrong Lumbiganon, Rawiwan Hansudewechakul, Kulkanya Chokephaibulkit, Khanh Huu Truong, Lam Van Nguyen, Kamarul Azahar Mohd Razali, Nik Khairulddin Nik Yusoff, Moy Siew Fong, Sirinya Teeraananchai, Jintanat Ananworanich, Nicolas Durier
We studied behavioral risks among HIV-infected and uninfected adolescents using an audio computer-assisted self-interview. A prospective cohort study was initiated between 2013 and 2014 in Malaysia, Thailand, and Vietnam. HIV-infected adolescents were matched to uninfected adolescents (4:1) by sex and age group (12-14 and 15-18 years). We enrolled 250 HIV-infected (48% male; median age 14.5 years; 93% perinatally infected) and 59 uninfected (51% male; median age 14.1 years) adolescents. At enrollment, HIV-infected adolescents were on antiretroviral therapy (ART) for a median (IQR) of 7...
January 16, 2018: AIDS Care
https://www.readbyqxmd.com/read/29332496/double-jeopardy-insurance-animal-harm-and-domestic-violence
#2
Tania Signal, Nik Taylor, Karena J Burke, Luke Brownlow
Although the role of companion animals within the dynamic of domestic violence (DV) is increasingly recognized, the overlap of animal harm and insurance discrimination for victims/survivors of DV has not been considered. Prompted by a case study presented in a National Link Coalition LINK-Letter, this research note examines "Pet Insurance" policies available in Australia and whether nonaccidental injury caused by an intimate partner would be covered. We discuss the implications of exclusion criteria for victims/survivors of DV, shelters providing places for animals within a DV dynamic, and, more broadly, for cross- or mandatory-reporting (of animal harm) initiatives...
June 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29330524/nf-%C3%AE%C2%BAb-inducing-kinase-is-a-therapeutic-target-for-systemic-lupus-erythematosus
#3
Hans D Brightbill, Eric Suto, Nicole Blaquiere, Nandhini Ramamoorthi, Swathi Sujatha-Bhaskar, Emily B Gogol, Georgette M Castanedo, Benjamin T Jackson, Youngsu C Kwon, Susan Haller, Justin Lesch, Karin Bents, Christine Everett, Pawan Bir Kohli, Sandra Linge, Laura Christian, Kathy Barrett, Allan Jaochico, Leonid M Berezhkovskiy, Peter W Fan, Zora Modrusan, Kelli Veliz, Michael J Townsend, Jason DeVoss, Adam R Johnson, Robert Godemann, Wyne P Lee, Cary D Austin, Brent S McKenzie, Jason A Hackney, James J Crawford, Steven T Staben, Moulay H Alaoui Ismaili, Lawren C Wu, Nico Ghilardi
NF-κB-inducing kinase (NIK) mediates non-canonical NF-κB signaling downstream of multiple TNF family members, including BAFF, TWEAK, CD40, and OX40, which are implicated in the pathogenesis of systemic lupus erythematosus (SLE). Here, we show that experimental lupus in NZB/W F1 mice can be treated with a highly selective and potent NIK small molecule inhibitor. Both in vitro as well as in vivo, NIK inhibition recapitulates the pharmacological effects of BAFF blockade, which is clinically efficacious in SLE...
January 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29329668/helicobacter-pylori-induces-direct-activation-of-the-lymphotoxin-beta-receptor-and-non-canonical-nuclear-factor-kappa-b-signaling
#4
Michael Hartmut Feige, Michael Vieth, Olga Sokolova, Christian Täger, Michael Naumann
The pathogen Helicobacter pylori, which infects half of the world's population, is a major risk factor for the development of gastric diseases including chronic gastritis and gastric cancer. Among H. pylori's virulence factors is the cytotoxin-associated gene pathogenicity island (cagPAI), which encodes for a type IV secretion system (T4SS). The T4SS induces fast canonical nuclear factor-kappa B (NF-κB) signaling, a major factor increasing inflammation, supressing apoptotic cell death and thereby promoting the development of neoplasia...
January 9, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29326084/impact-of-intracellular-ionic-strength-on-dimer-binding-in-the-nf-kb-inducing-kinase
#5
Michael R Jones, Joshua Yue, Angela K Wilson
Improper signaling of the nuclear factor-κB (NF-κB) pathway plays a critical role in many inflammatory disease states including cancer, stroke, and viral infections. Although the signaling pathways are known, how these molecular mechanisms respond to changes in the intracellular microenvironment such as pH, ionic strength, and temperature, remains elusive. Molecular dynamics simulations were employed to differentiate the structural dynamics of the NF-kB Inducing Kinase (NIK), a protein kinase responsible for invoking the non-canonical NF-κB pathway, in its native and mutant form, and in the absence and presence of salt concentration in efforts to probe whether changes in the ionic environment stabilize or destabilize the NIK dimer...
January 8, 2018: Journal of Structural Biology
https://www.readbyqxmd.com/read/29323295/alcohol-and-endogenous-aldehydes-damage-chromosomes-and-mutate-stem-cells
#6
Juan I Garaycoechea, Gerry P Crossan, Frédéric Langevin, Lee Mulderrig, Sandra Louzada, Fentang Yang, Guillaume Guilbaud, Naomi Park, Sophie Roerink, Serena Nik-Zainal, Michael R Stratton, Ketan J Patel
Haematopoietic stem cells renew blood. Accumulation of DNA damage in these cells promotes their decline, while misrepair of this damage initiates malignancies. Here we describe the features and mutational landscape of DNA damage caused by acetaldehyde, an endogenous and alcohol-derived metabolite. This damage results in DNA double-stranded breaks that, despite stimulating recombination repair, also cause chromosome rearrangements. We combined transplantation of single haematopoietic stem cells with whole-genome sequencing to show that this damage occurs in stem cells, leading to deletions and rearrangements that are indicative of microhomology-mediated end-joining repair...
January 11, 2018: Nature
https://www.readbyqxmd.com/read/29320732/stabilization-of-nf-%C3%AE%C2%BAb-inducing-kinase-suppresses-mll-af9-induced-acute-myeloid-leukemia
#7
Yan Xiu, Qianze Dong, Qingchang Li, Fengyin Li, Nick Borcherding, Weizhou Zhang, Brendan Boyce, Hai-Hui Xue, Chen Zhao
Canonical NF-κB signaling is constitutively activated in acute myeloid leukemia (AML) stem cells and is required for maintenance of the self-renewal of leukemia stem cells (LSCs). However, any potential role for NF-κB non-canonical signaling in AML has been largely overlooked. Here, we report that stabilization of NF-κB-inducing kinase (NIK) suppresses AML. Mechanistically, stabilization of NIK activates NF-κB non-canonical signaling and represses NF-κB canonical signaling. In addition, stabilization of NIK-induced activation of NF-κB non-canonical signaling upregulates Dnmt3a and downregulates Mef2c, which suppresses and promotes AML development, respectively...
January 9, 2018: Cell Reports
https://www.readbyqxmd.com/read/29317411/exposure-to-tobacco-secondhand-smoke-and-its-associated-factors-among-non-smoking-adults-in-smoking-restricted-and-non-restricted-areas-findings-from-a-nationwide-study-in-malaysia
#8
Kuang Hock Lim, Chien Huey Teh, Mohamad Haniki Nik Mohamed, Sayan Pan, Miaw Yn Ling, Muhammad Fadhli Mohd Yusoff, Noraryana Hassan, Nizam Baharom, Netty Darwina Dawam, Norliana Ismail, Sumarni Mohd Ghazali, Kee Chee Cheong, Kar Hon Chong, Hui Li Lim
OBJECTIVES: Secondhand smoke (SHS) has been associated with increased morbidity and mortality. Therefore, the aims of the paper are to assess SHS exposure among non-smoking adults in Malaysia attending various smoking-restricted and non-restricted public areas according to the Control of Tobacco Product Regulations (CTPR) as well as its relationship with various sociodemographic variables. DESIGN: Data were extracted from a cross-sectional study, the Global Adults Tobacco Survey (GATS) 2011 which involved 3269 non-smokers in Malaysia...
January 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29314081/predictors-and-outcomes-of-patients-requiring-repeat-transvenous-lead-extraction-of-pacemaker-and-defibrillator-leads
#9
Simon Claridge, Jonathan Johnson, Gazi Sadnan, Jonathan M Behar, Bradley Porter, Benjamin Sieniewicz, Tom Jackson, Jessica Webb, Justin Gould, Manav Sohal, Shoaib Hamid, Nik Patel, Jaswinder Gill, Christopher A Rinaldi
BACKGROUND: A proportion of patients who undergo an initial lead extraction procedure will require a second, repeat extraction. Data regarding this clinical entity are scarce and neither the predisposing risk factors for, nor outcomes from these procedures have been described previously. We sought to determine the incidence, risk factors and outcomes of repeat lead extraction. METHODS: A database of extraction procedures from 2001-2015 was analyzed. Repeat extraction procedures were identified and the indication for extraction was dichotomized into infection and lead related problems...
January 5, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29299674/kinetic-and-spectroscopic-characterization-of-tungsten-substituted-dmso-reductase-from-rhodobacter-sphaeroides
#10
Josué Pacheco, Dimitri Niks, Russ Hille
We have examined the kinetic and spectroscopic properties of a tungsten-substituted form of DMSO reductase from Rhodobacter sphaeroides, an enzyme that normally possesses molybdenum. Partial reduction with sodium dithionite yields a well-resolved W(V) EPR signal of the so-called "high-g split" type that exhibits markedly greater g-anisotropy than the corresponding Mo(V) signal of the native form of the enzyme, with the g values shifted to higher magnetic field by as much as Δgave = 0.056. Deuteration of the enzyme confirms that the coupled proton is solvent-exchangeable, allowing us to accurately simulate the tungsten hyperfine coupling...
January 3, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29296113/effect-of-different-types-of-toothpaste-on-the-frictional-resistance-between-orthodontic-stainless-steel-brackets-and-wires
#11
Tahereh Hosseinzadeh Nik, Tabassom Hooshmand, Homa Farhadifard
Objectives: The purpose of this study was to investigate the effect of different types of toothpaste on the frictional resistance between stainless steel brackets and archwires. Materials and Methods: Ninety stainless steel orthodontic brackets with stainless steel wires were bonded to bovine teeth and were divided into 6 groups for application of the following toothpastes: Colgate® Total® Advanced Whitening, Colgate® Total® Pro Gum Health, Colgate® Anticavity, Ortho...
September 2017: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/29288023/anterior-lens-capsule-strains-during-simulated-accommodation-in-porcine-eyes
#12
Antonio Pellegrino, Harvey John Burd, Laura Pinilla Cortés, Justin Christopher D'Antin, Nik Petrinic, Rafael I Barraquer, Ralph Michael
Experimental protocols have been developed to measure the spatial variation of the mechanical strains induced in the lens capsule during ex vivo lens stretching. The paper describes the application of these protocols to porcine lenses. The deformations and mechanical strains developed in the anterior capsule during each experiment were determined using full field digital image correlation techniques, by means of a speckle pattern applied to the lens surface. Several speckling techniques and illumination methods were assessed before a suitable combination was found...
December 26, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29285019/consolidation-radiotherapy-for-advanced-stage-aggressive-b-cell-non-hodgkin-lymphoma-a-systematic-review-and-meta-analysis
#13
REVIEW
Ernie Yap, Zhe Kang Law, Nik Muhd Aslan Abdullah, S Fadilah Abdul Wahid
Patients with advanced aggressive B-cell non-Hodgkin lymphomas (NHL) are usually treated with rituximab in combination with chemotherapy. However, disease relapse rates are high. Radiotherapy (RT) has been shown to be efficacious in treating early-stage NHL but its role in advanced stage diseases is unclear. We performed a systematic review of randomized controlled trials (RCTs) comparing chemotherapy with RT to chemotherapy alone in patients with newly diagnosed advanced aggressive NHL. We searched online databases and pooled similar outcome estimates...
2017: EXCLI Journal
https://www.readbyqxmd.com/read/29284006/sm22%C3%AE-suppresses-cytokine-induced-inflammation-and-the-transcription-of-nf-%C3%AE%C2%BAb-inducing-kinase-nik-by-modulating-srf-transcriptional-activity-in-vascular-smooth-muscle-cells
#14
Xiaohua Dai, Devi Thiagarajan, Jingye Fang, Jianbin Shen, Neeraja Priyanka Annam, Zhao Yang, Hong Jiang, Donghong Ju, Youming Xie, Kezhong Zhang, Yan Yuan Tseng, Zhe Yang, Arun K Rishi, Hui J Li, Maozhou Yang, Li Li
Vascular smooth muscle cell (VSMC) phenotypic modulation is characterized by the downregulation of SMC actin cytoskeleton proteins. Our published study shows that depletion of SM22α (aka SM22, Transgelin, an actin cytoskeleton binding protein) promotes inflammation in SMCs by activating NF-κB signal pathways both in cultured VSMCs and in response to vascular injury. The goal of this study is to investigate the underlying molecular mechanisms whereby SM22 suppresses NF-κB signaling pathways under inflammatory condition...
2017: PloS One
https://www.readbyqxmd.com/read/29277333/isolation-of-leptospira-kmetyi-from-residential-areas-of-patients-with-leptospirosis-in-kelantan-malaysia
#15
Mohammad Ridhuan Mohd Ali, Amira Wahida Mohamad Safiee, Nik Yuszrin Yusof, Mohd Hashairi Fauzi, Chan Yean Yean, Nabilah Ismail
BACKGROUND: Environmental sampling provides important information that enhances the understanding of the leptospiral human-environment-animal relationship. Several studies have described the distribution of Leptospira in the environment. However, more targeted sites, that is, areas surrounding leptospirosis patients' houses, remain under-explored. Therefore, this study aims to detect the presence of Leptospira spp. in the residential areas of patients with leptospirosis. METHODS: Soil and water samples near leptospirosis patients' residences were collected, processed and cultured into EMJH media...
December 22, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29259025/noncanonical-nf-%C3%AE%C2%BAb-signaling-and-the-essential-kinase-nik-modulate-crucial-features-associated-with-eosinophilic-esophagitis-pathogenesis
#16
Kristin Eden, Daniel E Rothschild, Dylan K McDaniel, Bettina Heid, Irving C Allen
Eosinophilic esophagitis (EoE) is an allergic disease of the esophagus driven by T cell and eosinophil responses to dietary allergens, resulting in chronic mucosal inflammation. Few spontaneous animal models of esophageal eosinophilia exist, with most studies relying on artificial sensitization procedures. NF-κB-inducing kinase (NIK; MAP3K14) is a key signaling molecule of the noncanonical NF-κB (NFKB1) pathway, an alternative signaling cascade producing chemokines involved in lymphoid stroma development and leukocyte trafficking...
December 19, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29258292/corrigendum-phylogenetic-ctdna-analysis-depicts-early-stage-lung-cancer-evolution
#17
Christopher Abbosh, Nicolai J Birkbak, Gareth A Wilson, Mariam Jamal-Hanjani, Tudor Constantin, Raheleh Salari, John Le Quesne, David A Moore, Selvaraju Veeriah, Rachel Rosenthal, Teresa Marafioti, Eser Kirkizlar, Thomas B K Watkins, Nicholas McGranahan, Sophia Ward, Luke Martinson, Joan Riley, Francesco Fraioli, Maise Al Bakir, Eva Grönroos, Francisco Zambrana, Raymondo Endozo, Wenya Linda Bi, Fiona M Fennessy, Nicole Sponer, Diana Johnson, Joanne Laycock, Seema Shafi, Justyna Czyzewska-Khan, Andrew Rowan, Tim Chambers, Nik Matthews, Samra Turajlic, Crispin Hiley, Siow Ming Lee, Martin D Forster, Tanya Ahmad, Mary Falzon, Elaine Borg, David Lawrence, Martin Hayward, Shyam Kolvekar, Nikolaos Panagiotopoulos, Sam M Janes, Ricky Thakrar, Asia Ahmed, Fiona Blackhall, Yvonne Summers, Dina Hafez, Ashwini Naik, Apratim Ganguly, Stephanie Kareht, Rajesh Shah, Leena Joseph, Anne Marie Quinn, Phil A Crosbie, Babu Naidu, Gary Middleton, Gerald Langman, Simon Trotter, Marianne Nicolson, Hardy Remmen, Keith Kerr, Mahendran Chetty, Lesley Gomersall, Dean A Fennell, Apostolos Nakas, Sridhar Rathinam, Girija Anand, Sajid Khan, Peter Russell, Veni Ezhil, Babikir Ismail, Melanie Irvin-Sellers, Vineet Prakash, Jason F Lester, Malgorzata Kornaszewska, Richard Attanoos, Haydn Adams, Helen Davies, Dahmane Oukrif, Ayse U Akarca, John A Hartley, Helen L Lowe, Sara Lock, Natasha Iles, Harriet Bell, Yenting Ngai, Greg Elgar, Zoltan Szallasi, Roland F Schwarz, Javier Herrero, Aengus Stewart, Sergio A Quezada, Karl S Peggs, Peter Van Loo, Caroline Dive, C Jimmy Lin, Matthew Rabinowitz, Hugo J W L Aerts, Allan Hackshaw, Jacqui A Shaw, Bernhard G Zimmermann, Charles Swanton
This corrects the article DOI: 10.1038/nature22364.
December 20, 2017: Nature
https://www.readbyqxmd.com/read/29247929/role-of-dissolved-oxygen-on-the-degradation-mechanism-of-reactive-green-19-and-electricity-generation-in-photocatalytic-fuel-cell
#18
Sin-Li Lee, Li-Ngee Ho, Soon-An Ong, Yee-Shian Wong, Chun-Hong Voon, Wan Fadhilah Khalik, Nik Athirah Yusoff, Noradiba Nordin
In this study, a membraneless photocatalytic fuel cell with zinc oxide loaded carbon photoanode and platinum loaded carbon cathode was constructed to investigate the impact of dissolved oxygen on the mechanism of dye degradation and electricity generation of photocatalytic fuel cell. The photocatalytic fuel cell with high and low aeration rate, no aeration and nitrogen purged were investigated, respectively. The degradation rate of diazo dye Reactive Green 19 and the electricity generation was enhanced in photocatalytic fuel cell with higher dissolved oxygen concentration...
November 29, 2017: Chemosphere
https://www.readbyqxmd.com/read/29233777/characterization-and-pathogenicity-of-fusarium-species-associated-with-leaf-spot-of-mango-mangifera-indica-l
#19
Nurul Husna Omar, Masratulhawa Mohd, Mohamed Nor Nik Mohd Izham, Latiffah Zakaria
Leaf spot diseases are mainly caused by fungi including Fusarium. In the present study several species of Fusarium were isolated from the leaf spot lesion of mango (Mangifera indica L.) Based on morphological characteristics, TEF-1α sequences and phylogenetic analysis, five species were identified as F. proliferatum, F. semitectum, F. mangiferae, F. solani and F. chlamydosporum. Pathogenicity test indicated that representative isolates of F. proliferatum, F. semitectum and F. chlamydosporum were pathogenic on mango leaves causing leaf spot with low to moderate virulence...
December 9, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29233325/malaysian-pharmacy-students-intention-to-provide-smoking-cessation-counseling
#20
Saraswathi Simansalam, Siti Hadijah Shamsudin, Mohamad Haniki Nik Mohamed
BACKGROUND AND PURPOSE: Malaysian National Quit Smoking Program had proposed to integrate smoking cessation counseling skills into all relevant healthcare curricula as one of its strategies to increase the number of Malaysians giving up smoking. More effective implementation of the curricula can be facilitated by further understanding the factors influencing students' intention in terms of providing smoking cessation counseling. This study, guided by Integrated Behavior Model (IBM), aimed to explore the factors which influenced pharmacy undergraduates in providing smoking cessation counseling...
September 2017: Currents in Pharmacy Teaching & Learning
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