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https://www.readbyqxmd.com/read/28100077/effects-of-m2000-d-mannuronic-acid-on-learning-memory-retrieval-and-associated-determinants-in-a-rat-model-of-alzheimer-s-disease
#1
Somayeh Athari Nik Azm, Mohammadreza Vafa, Mohammad Sharifzadeh, Majid Safa, Anis Barati, Abbas Mirshafiey
The d-mannuronic acid (M2000) is a novel nonsteroidal anti-inflammatory drug that has immunosuppressive effects together with antioxidant property. M2000 has shown a notable efficacy in experimental models of multiple sclerosis, rheumatoid arthritis, and nephrotic syndrome. In this work, the effect of M2000 on the treatment of Alzheimer's disease (AD) was performed by Morris water maze experiment, and the immunological assessments were carried out by Western blot, apoptosis (procaspase-3, Bax/Bcl2, P53), enzymatic (superoxide dismutase [SOD]), and nonenzymatic oxidative stress (malondialdehyde [MDA]) tests...
February 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28087967/periampullary-carcinoma-with-penile-metastasis
#2
W C Pui, N A Nik Azim
Periampullary carcinoma metastases are usually located at regional nodes, adjacent organs, liver or lung. On the other hand, metastatic penile cancer is uncommon. Penile metastasis usually originates from pelvic region with prostate and bladder being the most frequent primary location. We present a very rare case of periampullary carcinoma with penile metastasis in a 49-year-old man. He initially presented with early ampullary type periampullary carcinoma and had pyloric preserving pancreatoduodenectomy and adjuvant chemotherapy...
December 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28087959/a-study-on-hla-dr-dq-typing-in-adult-malay-patients-with-acute-amoebic-liver-abscess
#3
Z Nazli, N M S Azira, M Zeehaida, Z Nik Zairi, Y Nurul Khaiza, Y Maya Mazuwin
INTRODUCTION: Amoebiasis is a parasitic disease caused by Entamoeba histolytica that may lead to death in developing countries. Few important risk factors have been identified in the development of amoebic liver abscess (ALA). There are limited reports that suggest an association between antigens of the major histocompatibility complex (MHC) particularly class II antigens and ALA development. This present work aimed at studying the possible association of HLA antigens with ALA and disease severity...
December 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28087349/combination-of-multiple-ligation-dependent-probe-amplification-and-illumina-miseq-amplicon-sequencing-for-tsc1-tsc2-gene-analyses-in-patients-with-tuberous-sclerosis-complex
#4
Nur Farrah Dila Ismail, Abdul Qawee Rani, Nik Mohd Ariff Nik Abdul Malik, Chia Boon Hock, Siti Nabilahuda Mohd Azlan, Salmi Abdul Razak, Wee Teik Keng, Lock Hock Ngu, Abdul Rashid Silawati, Nor AzniYahya, Narazah Mohd Yusoff, Teguh Haryo Sasongko, Zabidi Azhar Mohd Hussin
Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disorder characterized by tumor growth in multiple organs and caused by mutations in either TSC1 or TSC2 genes. Because of their relatively large genomic sizes, absence of hotspots, and common type of mutations, mutation detection in TSC1 and TSC2 genes has been challenging. We devised a combination of multiple ligation-dependent probe amplification (MLPA) and amplicon sequencing (AS) to simplify the detection strategy, yet we come up with reasonably high detection rate...
January 10, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28077648/human-papillomavirus-16-e6-up-regulates-apobec3b-via-the-tead-transcription-factor
#5
Seiichiro Mori, Takamasa Takeuchi, Yoshiyuki Ishii, Takashi Yugawa, Tohru Kiyono, Hiroshi Nishina, Iwao Kukimoto
: The cytidine deaminase APOBEC3B (A3B) underlies the genetic heterogeneity of several human cancers including cervical cancer, which is caused by human papillomavirus (HPV) infection. We previously identified a region within the A3B promoter that is activated by the viral protein HPV16 E6 in human keratinocytes. Here, we discovered three sites recognized by the TEAD family of transcription factors within this region of the A3B promoter. Reporter assays in HEK293 cells showed that exogenously expressed TEAD4 induced A3B promoter activation through binding to these sites...
January 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28069249/barriers-to-intensive-care-unit-nurses-autonomy-in-iran-a%C3%A2-qualitative-study
#6
Maryam AllahBakhshian, Nasrollah Alimohammadi, Fariba Taleghani, Ahmadreza Yazdan Nik, Saeed Abbasi, Leila Gholizadeh
BACKGROUND: The acute nature of the intensive care unit (ICU) environment necessitates that urgent clinical decisions are frequently made by the health care team. Therefore, it is important that critical care nurses have the authority to make decisions about their patient care. PURPOSE: The purpose of this study was to explore perceived barriers to the practice of professional autonomy from the perspectives of ICU nurses in Iran. METHODS: In this qualitative study, 28 critical care nurses were interviewed using a semistructured in-depth interview method...
December 20, 2016: Nursing Outlook
https://www.readbyqxmd.com/read/28064492/influence-of-winemaking-processing-steps-on-the-amounts-of-e-2-decenal-and-tridecane-as-off-odorants-caused-by-brown-marmorated-stink-bug-halyomorpha-halys
#7
Pallavi Mohekar, James Osborne, Nik G Wiman, Vaughn Walton, Elizabeth Tomasino
Brown marmorated stink bugs (BMSB) release stress compounds, tridecane and (E)-2-decenal, that effect final wine quality. This study focuses on determining the effect of wine processing on (E)-2-decenal and tridecane release in both red and white wines. Wines were produced by adding live BMSB to grape clusters at densities of 0, 0.3, 1 and 3 bugs per cluster. Compound concentrations were measured using HS-SPME-MDGC-MS. For red wines, the highest levels of stress compounds were found using 3 BMSB/cluster (tridecane, 614 µg/L and (E)-2-decenal, 2...
January 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28062430/rare-and-unusual-case-of-polyarteritis-nodosa-involving-the-gastrointestinal-tract-leading-to-bowel-gangrene
#8
Arvind Vashdev Jagwani, Nik Qisti Fathi, Ruhi Fadzlyana Jailani, Andee Dzulkarnaen Zakaria
Polyarteritis nodosa (PAN) is a systemic necrotising vasculitis preferentially targeting medium-sized arteries and not related with glomerulonephritis or small vessel involvement. Clinical manifestations of PAN are multisystem. The gastrointestinal, renal, cardiac, musculoskeletal, skin and central nervous systems may be involved. The aetiology remains unknown, and the ensuing vasculitis may lead to aneurysm formation and thrombosis in any organs of the body with resultant ischaemia. PAN of the intestines is a relatively common manifestation of this disease but rarely causes bowel ischaemia resulting in necrosis...
January 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28061942/a-study-on-hydrodynamic-behavior-of-fine-sediment-in-retention-structure-using-particle-image-velocimetry
#9
Masoumeh MoayeriKashani, Lai Sai Hin, Shaliza Ibrahim, Nik Meriam Nik Sulaiman
  Detention ponds are one type of stormwater best management practices (BMPs) that can be used for the quantity control of stormwater. The pond works by reducing peak discharge downstream through temporary storage and gradual release. In this paper, a new experimental procedure using particle image velocimetry (PIV) is introduced for a two-dimensional study of the hydrodynamic behavior of fine particles in a specially designed sediment basin. The hydrodynamic behavior of fine particles under different hydraulics parameters was achieved by shifting outlet placement, using different particle-size diameters, varying the distance of the inlet from the water surface, and varying the flow rate...
December 1, 2016: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28058617/the-impact-of-increasing-hospital-volume-on-90-day-postoperative-outcomes-following-pancreaticoduodenectomy
#10
Daniel J Kagedan, Nik Goyert, Qing Li, Lawrence Paszat, Alexander Kiss, Craig C Earle, Paul J Karanicolas, Alice C Wei, Nicole Mittmann, Natalie G Coburn
BACKGROUND: Performance of pancreaticoduodenectomy (PD) in high-volume centers has been posited to improve postoperative morbidity and mortality, consistent with the volume-outcomes hypothesis. We sought to evaluate the impact of hospital volume on 90-day PD outcomes at hepatopancreatobiliary (HPB) centers within a regionalized system. METHODS: A retrospective population-based observational cohort study was performed, using administrative records of patients undergoing PD between 2005 and 2013 in Ontario, Canada...
January 5, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28049766/nik-sends-mitochondria-to-the-periphery
#11
Annalisa M VanHook
No abstract text is available yet for this article.
January 3, 2017: Science Signaling
https://www.readbyqxmd.com/read/28043716/synthesis-molecular-docking-studies-of-hybrid-benzimidazole-as-%C3%AE-glucosidase-inhibitor
#12
Nik Khairunissa Nik Abdullah Zawawi, Muhammad Taha, Norizan Ahmat, Nor Hadiani Ismail, Abdul Wadood, Fazal Rahim
Thiourea derivatives having benzimidazole 1-17 have been synthesized, characterized by (1)H NMR, (13)C NMR and EI-MS and evaluated for α-glucosidase inhibition. Identification of potential α-glucosidase inhibitors were done by in vitro screening of 17 thiourea bearing benzimidazole derivatives using Baker's yeast α-glucosidase enzyme. Compounds 1-17 exhibited a varying degree of α-glucosidase inhibitory activity with IC50 values between 35.83±0.66 and 297.99±1.20μM which are more better than the standard acarbose (IC50=774...
December 26, 2016: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28007361/a-perfect-storm-tyrosine-kinase-inhibitor-associated-polymorphic-ventricular-tachycardia
#13
Alexander Beyer, Beejal Ganti, Allen Majkrzak, Nik Theyyunni
BACKGROUND: Oral tyrosine kinase inhibitors (TKIs) are becoming increasingly common in oncology practice due to ease of administration and patient preference. This class of medications is relatively unknown to emergency physicians. CASE REPORT: Here we present a case of electrical storm (ES) thought to be associated with ibrutinib, a TKI. The ES was unabated despite antidysrhythmic therapy and electrical cardioversion, and was treated with supportive care, which eventually included the use of extracorporeal membrane oxygenation...
December 19, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28005357/structure-based-design-of-tricyclic-nf-%C3%AE%C2%BAb-inducing-kinase-nik-inhibitors-that-have-high-selectivity-over-phosphoinositide-3-kinase-pi3k
#14
Georgette M Castanedo, Nicole Blaquiere, Maureen Beresini, Brandon Bravo, Hans Brightbill, Jacob Chen, Hai-Feng Cui, Charles Eigenbrot, Christine Everett, Jianwen Feng, Robert Godemann, Emily Gogol, Sarah Hymowitz, Adam Johnson, Nobuhiko Kayagaki, Pawan Bir Kohli, Kathleen Knüppel, Joachim Kraemer, Susan Krüger, Pui Loke, Paul McEwan, Christian Montalbetti, David A Roberts, Myron Smith, Stefan Steinbacher, Swathi Sujatha-Bhaskar, Ryan Takahashi, Xiaolu Wang, Lawren C Wu, Yamin Zhang, Steven T Staben
We report here structure-guided optimization of a novel series of NF-κB inducing kinase (NIK) inhibitors. Starting from a modestly potent, low molecular weight lead, activity was improved by designing a type 11/2 binding mode that accessed a back pocket past the methionine-471 gatekeeper. Divergent binding modes in NIK and PI3K were exploited to dampen PI3K inhibition while maintaining NIK inhibition within these series. Potent compounds were discovered that selectively inhibit the nuclear translocation of NF-κB2 (p52/REL-B) but not canonical NF-κB1 (REL-A/p50)...
January 12, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28004229/patient-specific-3d-hemodynamics-modelling-of-left-coronary-artery-under-hyperemic-conditions
#15
Sarfaraz Kamangar, Irfan Anjum Badruddin, Kalimuthu Govindaraju, N Nik-Ghazali, A Badarudin, Girish N Viswanathan, N J Salman Ahmed, T M Yunus Khan
The purpose of this study is to investigate the effect of various degrees of percentage stenosis on hemodynamic parameters during the hyperemic flow condition. 3D patient-specific coronary artery models were generated based on the CT scan data using MIMICS-18. Numerical simulation was performed for normal and stenosed coronary artery models of 70, 80 and 90% AS (area stenosis). Pressure, velocity, wall shear stress and fractional flow reserve (FFR) were measured and compared with the normal coronary artery model during the cardiac cycle...
December 21, 2016: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/27965749/oviposition-habitat-selection-of-dengue-vectors-aedes-aegypti-and-aedes-albopictus-in-response-to-fish-predator
#16
Wan Fatma Zuharah, Nik Fadzly, Wilson Ong Kang Wei, Zarul Hazrin Hashim
To understand the effects of fish predator's kairomones on Aedes mosquitoes' oviposition, we established an experiment using gravid Aedes females. Kairomones concentrations were established using Hampala macrolepidota. One individual fish was placed inside containers with varying water levels (1 L, 5 L, and 10 L of water). The fish were kept in the containers for 24 hours and were removed immediately at the start of each trial in order to have the kairomones remnants. Twenty gravid adult females of Aedes aegypti and Aedes albopictus were allowed to lay eggs on oviposition site with various treatments: (1) control without any kairomones; (2) kairomone remnant in 1 L of water; (3) kairomone remnant in 5 L of water; and (4) kairomone remnant in 10 L of water...
November 2016: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/27965746/the-effects-of-light-and-height-of-building-in-attracting-paederus-fuscipes-curtis-to-disperse-towards-human-residential-areas
#17
Sufian Maryam, Nik Fadzly, Wan Fatma Zuharah
Paederus fuscipes Curtis is a nocturnal insect. The attractiveness of artificial light sources from residential premises eventually causes the risk of severe dermatitis effect, once Paederus is in contact with human skin. The objective of this study is to investigate whether the light and height factors of residential buildings and its' association to rice cultivation phases are primary reasons for P. fuscipes's mass dispersal into human residential areas. The study site was located in residential premises that were built adjacent to rice field areas (≈ 32-60 m and 164 m) north of the rice field located in Teluk Air Tawar, mainland of Pulau Pinang...
November 2016: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/27965734/the-effect-of-macrocyclic-lactones-ivermectin-exposure-on-egg-hatching-and-larval-development-of-caenorhabditis-elegans
#18
Mariani Mohd Zain, Zary Shariman Yahaya, Nik Ahmad Irwan Izzauddin Nik Him
To date, the ivermectin resistance in nematode parasites has been reported and many studies are carried out to determine the causes of this problem. A free-living Caenorhabditis elegans is used as a model system for this study to investigate the response of C. elegans to ivermectin exposure by using larval development assay. Worms were exposed to ivermectin at concentration from 1 ng/mL to 10 ng/mL and dimethyl sulphoxide (DMSO) as a control. The developments of the worms were monitored for 24, 48, 72, and 96 hours until the worms become adults...
November 2016: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/27956387/targeting-sphingosine-kinase-1-induces-mcl1-dependent-cell-death-in-acute-myeloid-leukemia
#19
Jason A Powell, Alexander C Lewis, Wenying Zhu, John Toubia, Melissa R Pitman, Craig T Wallington-Beddoe, Paul A B Moretti, Diana Iarossi, Saumya E Samaraweera, Nik Cummings, Hayley S Ramshaw, Daniel Thomas, Andrew H Wei, Angel F Lopez, Richard J D'Andrea, Ian D Lewis, Stuart M Pitson
Acute myeloid leukemia (AML) is an aggressive malignancy where despite improvements in conventional chemotherapy and bone marrow transplantation, overall survival remains poor. Sphingosine kinase 1 (SPHK1) generates the bioactive lipid sphingosine 1-phosphate (S1P) and has established roles in tumor initiation, progression and chemotherapy resistance in a wide range of cancers. The role and targeting of SPHK1 in primary AML, however, has not been previously investigated. Here we show that SPHK1 is overexpressed and constitutively activated in primary AML patient blasts but not in normal mononuclear cells...
December 12, 2016: Blood
https://www.readbyqxmd.com/read/27942345/the-buffering-analysis-to-identify-common-geographical-factors-within-the-vicinity-of-severe-injury-related-to-motor-vehicle-crash-in-malaysia
#20
Nik Hisamuddin Rahman, Ruslan Rainis, Syed Hatim Noor, Sharifah Mastura Syed Mohamad
BACKGROUND: The main objective was to identify common geographical buildup within the 100-meter buffer of severely injured based on injury severity score (ISS) among the motor vehicle crash (MVC) victims in Malaysia. METHODS: This was a prospective cohort study from July 2011 until June 2013 and involved all MVC patients attending emergency departments (ED) of two tertiary centers in a district in Malaysia. A set of digital maps was obtained from the Town Planning Unit of the district Municipal Office (local district map)...
2016: World Journal of Emergency Medicine
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