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Pterygium

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https://www.readbyqxmd.com/read/27911382/a-simple-mechanical-procedure-to-create-limbal-stem-cell-deficiency-in-mouse
#1
Neda Afsharkhamseh, Elham Ghahari, Medi Eslani, Ali R Djalilian
Limbal stem cell deficiency (LSCD) is a state of malfunction or loss of limbal epithelial stem cells, after which the corneal epithelium is replaced with conjunctiva. Patients suffer from recurrent corneal defects, pain, inflammation, and loss of vision. Previously, a murine model of LSCD was described and compared to two other models. The goal was to produce a consistent mouse model of LSCD that both mimics the phenotype in humans and lasts long enough to make it possible to study the disease pathophysiology and to evaluate new treatments...
November 17, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27904208/verrucous-onychomycosis-caused-by-curvularia-in-a-patient-with-congenital-pterygium
#2
Mary Vineetha, Seena Palakkal, K Sobhanakumari, M I Celine, V Letha
A 57 year healthy farmer with congenital nail pterygium presented with a verrucous growth on nail bed since 8 months. He was not diabetic and HIV rapid card test negative. Our clinical diagnosis was chromoblastomycosis but culture showed growth of curvularia species on two occasions and histopathology showed hyphal and yeast forms of the pigmented fungus. After excision biopsy patient was started on oral itraconazole. This case is reported due to rarity of verrucous cutaneous lesions caused by curvularia in immunocompetent individuals...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27902173/escobar-multiple-pterygium-syndrome-multidisciplinary-approach-to-a-very-rare-syndrome
#3
Murat Celal Sözbilen, Hüseyin Günay, Funda Atamaz Çalış
Escobar (multiple pterygium) syndrome is progressive and a very rare syndrome. It is generally characterized by multiple pterygia that are found in the cervical, antecubital and popliteal regions. In this report, we present the treatment management of a 14-year-old case with late stage Escobar syndrome who was admitted due to multiple pterygia and bilateral knee contractures. The treatment of this case was conducted in collaboration with the department of orthopedics and the department of physical therapy. The treatment of the case was done in three stages: soft tissue procedures, femoral recurvatum osteotomy and triple arthrodesis, respectively...
December 2016: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/27897118/smoking-and-eye-pathologies-a-systemic-review-part-i-anterior-eye-segment-pathologies
#4
Małgorzata Nita, Andrzej Grzybowski
BACKGROUND: Tobacco smoking has detrimental influence on human health and is one of the leading causes of preventable mortality worldwide, associated with lung cancer, chronic obstructive lung disease and cardiovascular disease. AIM: The analysis of the influence of tobacco smoking on pathology of the anterior segment of the eye in adults and children. METHODS: A comprehensive review of the literature performed through MEDLINE and PubMed searches, was published during the period 2000-2016...
November 29, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27896441/pterygium-surgery-using-the-principle-of-contact-inhibition-results-of-13-years-experience
#5
Tsutomu Hara, Takako Hashimoto, Takeshi Hara
PURPOSE: To report a technique to prevent pterygium recurrence using the principle of contact inhibition. METHODS: Two hundred and fifteen patients (232 eyes; average age, 64.1 years) with primary pterygia who underwent pterygium surgery at the Hara Eye Hospital between 1999 and 2012. We retrospectively evaluated the patients who underwent the following procedure to prevent pterygium recurrence. The surface conjunctiva on the pterygium body was not removed. After removing the pterygium body, by placing a narrow pedicle autoconjunctival flap along the corneal limbus and tying it tightly to the front area of the residual conjunctiva, there is no room for the active residual tissue to proliferate, thus preventing a recurrence by contact inhibition...
November 28, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27872516/proliferative-effects-of-histamine-on-primary-human-pterygium-fibroblasts
#6
Zhenwei Qin, Qiuli Fu, Lifang Zhang, Houfa Yin, Xiuming Jin, Qiaomei Tang, Danni Lyu, Ke Yao
Purpose. It has been confirmed that inflammatory cytokines are involved in the progression of pterygium. Histamine can enhance proliferation and migration of many cells. Therefore, we intend to investigate the proliferative and migratory effects of histamine on primary culture of human pterygium fibroblasts (HPFs). Methods. Pterygium and conjunctiva samples were obtained from surgery, and toluidine blue staining was used to identify mast cells. 3-[4, 5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) was performed to evaluate the proliferative rate of HPFs and human conjunctival fibroblasts (HCFs); ki67 expression was also measured by immunofluorescence analysis...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27854142/effects-of-mitomycin-c-in-early-conjunctival-inflammation-after-pterygium-surgery
#7
Claudia da Costa Paula, Gemma Julio, Pamela Campos, Pere Pujol, Mouafk Asaad
PURPOSE: The purpose of this study was to compare inflammatory events and graft characteristics 1 month and 6 months after conjunctival limbal autograft (CLAU) with and without intraoperative mitomycin C (MMC). METHODS: This study included 69 eyes of 69 patient's eyes with pterygium. Clinical data concerning patient demography, preoperative examination including pterygium morphology, recurrence clinical assessment, and complications after CLAU with (MMC+) and without (MMC-) intraoperative MMC were all registered at 1 month and 6 months after surgery...
November 17, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27853018/infectious-pseudomonas-and-bipolaris-scleritis-following-history-of-pterygium-surgery
#8
Ashkan M Abbey, Nisha V Shah, Richard K Forster, Leejee H Suh
We report an interesting case of infectious scleritis from coinfection of Pseudomonas aeruginosa and Bipolaris with no corneal infiltrate. A healthy 60-year-old man with a history of infectious scleritis following pterygium excision presented with purulent material growing P. aeruginosa and 1+ colonies of Bipolaris species of fungus. Broad spectrum treatment was initiated with hourly topical moxifloxacin, fortified tobramycin, and natamycin along with a subconjunctival injection of voriconazole and topical cyclosporine, with PO ketoconazole...
September 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27843868/lethal-multiple-pterygium-syndrome
#9
Tulika Joshi, Nazia Nagori Noor, Moolraj Kural, Amita Tripathi
The multiple pterygium syndrome is consist of wide range of fetal malformations which have a genetic linkage. A defect in embryonic acetylcholine receptor which can be inherited as autosomal recessive, autosomal dominant, or X-linked fashion is the cause of this syndrome. We present a sporadic case of lethal multiple pterygium syndrome.
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27834959/k-ras-oncogene-mutation-in-pterygium
#10
B T Ozturk, M S Yıldırım, A Zamani, B Bozkurt
PurposePterygium is claimed to be a benign proliferation triggered by prolonged exposure to ultraviolet radiation. The frequency of K-ras oncogene mutation, which is among the initial mutations in tumorigenesis, is evaluated in this study.Patients and methodsIn this prospective randomized clinical, trial pterygium tissues and normal conjunctiva tissue specimens are obtained from the superotemporal quadrant of patients who underwent primary pterygium excision with autograft transplantation. DNA extraction from tissues was performed using the QIAamp DNA FFPE tissue kit...
November 11, 2016: Eye
https://www.readbyqxmd.com/read/27817915/evicel-versus-tisseel-versus-sutures-for-attaching-conjunctival-autograft-in-pterygium-surgery-a-prospective-comparative-clinical-study
#11
Ofira Zloto, Eran Greenbaum, Ido Didi Fabian, Guy J Ben Simon
PURPOSE: To evaluate the outcome of pterygium surgery with conjunctival autograft using Vicryl sutures (Ethicon, NJ), Evicel fibrin glue (Omrix Biopharmaceuticals Ltd, Ramar-Gan, Israel), or Tisseel fibrin glue (Baxter Corp., Mississauga, Canada). DESIGN: Prospective, randomized study. PARTICIPANTS: Eighty-nine adult patients with primary pterygium. METHODS: Patients undergoing pterygium surgery with conjunctival autografting were randomized into groups receiving 10-0 Vicryl sutures, Evicel fibrin glue, or Tisseel fibrin glue...
November 3, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27800243/demographics-of-patients-with-double-headed-pterygium-and-surgical-outcomes
#12
Fulya Duman, Mustafa Köşker
OBJECTIVES: To analyze demographic and ophthalmologic characteristics of patients with double-headed pterygium in the Mediterranean region of Turkey and to evaluate their surgical outcomes. MATERIALS AND METHODS: Records of all patients who underwent surgery for pterygium in Antalya Atatürk State Hospital between November 2012 and March 2014 were retrospectively reviewed. Patients with pterygia on both sides of the cornea (nasal and temporal) were included in the study...
December 2015: Turk J Ophthalmol
https://www.readbyqxmd.com/read/27761704/limbal-conjunctival-versus-amniotic-membrane-in-the-intraoperative-application-of-mitomycin-c-for-recurrent-pterygium-a-randomized-controlled-trial
#13
Rongxin Chen, Guofu Huang, Shu Liu, Wenfang Ma, Xiaofang Yin, Shiyou Zhou
PURPOSE: This study compared the outcomes of a limbal conjunctival autograft (LCAG) with those of an amniotic membrane graft (AMG) followed by intraoperative 0.02 % mitomycin C (MMC) to treat recurrent pterygium. METHODS: In this randomized controlled trial, ninety-six eyes with recurrent pterygium were enrolled and randomly allocated into two groups using a computer-generated random number table. Pterygium removal was followed by intraoperative 0.02 % MMC for 3 min and then either LCAG or AMG transplantation...
October 20, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27760648/-study-on-the-evaluation-of-pterygium-activity-with-in-vivo-confocal-microscopy
#14
Q F Liang, C Gao, H Liang, B Li, X H Du, Antoine Labbe
Objective: To observe the characteristics of pterygium with in vivo confocal microscopy (IVCM) and understand pterygium activity with the density of inflammatory cells, formation of new blood vessels, and the number of activated keratocytes within the stroma. Methods: A prospective case-controlled study. Thirty-six pterygia from 28 patients were analyzed in this study. A pterygium activity score was obtained by summing four scores of ocular discomfort, pterygium hyperemia, keratitis, and the presence of Fuchs patches...
October 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27755162/subtenon-injections-of-ranibizumab-arrest-growth-in-early-recurrent-pterygium
#15
Linda Rose, Julia M Byrd, Yousuf Qaseem
IMPORTANCE: Currently the only treatment for recurrent pterygium is surgery. This is a phase 1 trial investigating ranibizumab as a medical treatment for recurrent pterygium. OBJECTIVE: To assess the safety and efficacy of subtenon Ranibizimab for recurrent pterygia. DESIGN: Subjects with recurrent pterygium received subtenon ranibizumab and were followed for 1 year. Safety parameters were measured. Photographs were taken and quantitatively analyzed to measure the short-term (2 months) and long-term (5-26 months) response to treatment...
October 7, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27749471/comparison-of-different-measurement-tools-and-dimensional-parameters-of-pterygium-to-investigate-its-impact-on-refractive-indices-and-ocular-aberrations
#16
Koray Gumus, Aysegul Guven, Miray Altnkaynak, Merve Keskin
OBJECTIVES: The aim of this study was to compare different measurement tools and parameters, including a new computer-assisted image processing technique for the quantitative analysis of the percentage of pterygium on the corneal surface, horizontal/vertical lengths obtained using slitlamp beam and surgical compass. METHODS: A total of 21 pterygia of 17 patients were included in the study. The pterygia were measured by three different methods: a slitlamp beam, a surgical compass, and a new computer-assisted image processing method...
September 30, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27749451/recurrence-rate-and-complications-of-pterygium-extended-removal-followed-by-extended-conjunctival-transplant
#17
Curtis R Cornelius
PURPOSE: Independent evaluation of efficacy of P.E.R.F.E.C.T. for PTERYGIUM technique in preventing recurrence after pterygium surgery. METHODS: Sixty consecutive cases of primary pterygium excision were performed between November 2006 and April 2012 using the P.E.R.F.E.C.T. for PTERYGIUM technique. RESULTS: Fifty-four (90%) cases were followed up for at least 1 year, and 58 (97%) were followed up for at least 6 months. There was 1 recurrence (1...
October 5, 2016: Cornea
https://www.readbyqxmd.com/read/27749449/double-headed-pterygia-treated-with-p-e-r-f-e-c-t-for-pterygium
#18
Lawrence W Hirst, Katherine Smallcombe
PURPOSE: There are very few studies that describe the technique and results of double-headed pterygium removal and most of these have recurrence rates higher than those described for single pterygium removal. P.E.R.F.E.C.T for PTERYGIUM has a very low recurrence rate, and this study describes the recurrence rate and cosmesis when used on double-headed pterygia. METHODS: A prospective intervention series was performed on 20 eyes with a follow-up of 1 year or more with examination for recurrence and cosmetic appearance...
October 5, 2016: Cornea
https://www.readbyqxmd.com/read/27749445/autoconjunctival-graft-compromise-after-pterygium-surgery-in-a-patient-receiving-intravitreal-anti-vascular-endothelial-growth-factor-injections
#19
Jeremy C K Tan, Melissa X Kuo, Minas T Coroneo
PURPOSE: To report on a case of autoconjunctival graft compromise after pterygium surgery in a patient on long-term anti-vascular endothelial growth factor (anti-VEGF) therapy, due to the deleterious effects of anti-VEGF agents on ocular wound healing. METHODS: A white female in her early eighties presented with large right nasal pterygium, first noted 5 years previously. She also had macular degeneration and had been receiving monthly injections of ranibizumab, which was later switched to aflibercept...
October 5, 2016: Cornea
https://www.readbyqxmd.com/read/27725197/in%C3%A2-vitro-secretomics-study-of-pterygium-derived-fibroblasts-by-itraq-based-quantitative-proteomics-strategy
#20
Aihua Hou, Kai Pong Law, Min Qi Tin, Yoon Pin Lim, Louis Tong
Pterygium is a triangular shaped ocular fibrous surface lesion growing from conjunctiva towards central cornea, causing ocular irritation, astigmatism, and visual disturbance. The condition is characterized by epithelial proliferation, fibrovascular growth, chronic inflammation, and prominent extracellular matrix remodeling. Studies have suggested that aberrant extracellular proteins secreted by fibroblasts lead to abnormal matrix production and tissue invasion contributing to the development of the disease...
October 8, 2016: Experimental Eye Research
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