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Pterygium

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https://www.readbyqxmd.com/read/28715851/paradigm-shifts-peregrinations-and-pixies-in-ophthalmology
#1
REVIEW
A O Minas Coroneo
Defending vision, our highest bandwidth sense, challenges human ingenuity. Replacing or repairing highly specialized but scarce tissue within constraints of transparency, tissue shape and alignment, tissue borders and pressure maintenance, presents special challenges. Many, mostly destructive surgical procedures, were developed prior to an understanding of underlying pathophysiology. For a number of conditions, both reconstructive and destructive procedures co-exist yet there are few guidelines as to the better approach...
July 17, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28704320/recurrence-rate-and-graft-stability-with-fibrin-glue-compared-with-suture-and-autologous-blood-coagulum-for-conjunctival-autograft-adherence-in-pterygium-surgery-a-meta-analysis
#2
Rituparna Maiti, Somnath Mukherjee, Debasish Hota
PURPOSE: To minimize recurrence and improve graft stability after pterygium surgery, conjunctival autograft adherence is done using fibrin glue (FG) or autologous blood coagulum (ABC). But there are studies that have reported conflicting or inconclusive results. This meta-analysis was conducted to evaluate the postoperative recurrence rate and graft stability after using FG, sutures, and ABC. METHODS: MEDLINE, Cochrane databases, and ICTRP were searched and PRISMA guidelines as well as recommended meta-analysis practices were followed...
July 11, 2017: Cornea
https://www.readbyqxmd.com/read/28695379/expression-of-prostaglandin-e2-receptor-subtypes-in-human-pterygium-and-normal-conjunctiva-immunohistochemical-study
#3
Erdem Dinç, Özer Dursun, Banu Yılmaz, Mustafa Vatansever, A Ayça Sarı, Özlem Yıldırım, Ufuk Adıgüzel
PURPOSE: In the present study, we aimed to evaluate the expression of EP receptors in primary and recurrent human pterygium tissues. METHODS: Pterygium samples were collected from 65 patients with primary pterygium and 16 patients with recurrent pterygium. Normal conjunctival tissues were collected from nasal interpalpebral area from 17 patients without systemic and any other ocular pathology. Expression of EP receptors was evaluated by immunohistochemistry. The median value for each receptor staining score (RSS) was determined in normal conjunctival specimens...
July 10, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28686975/overexpression-of-low-density-lipoprotein-receptors-stimulated-by-vascular-endothelial-growth-factor-in-fibroblasts-from-pterygium
#4
Mengliang Wu, Jiajian Wang, Qianwei Zhang, Yan Wang, Liangliang Niu, Tingting Shao
The activation of subconjunctival fibroblasts is believed to be responsible for the pathogenesis of pterygium. Vascular endothelial growth factor (VEGF) appears to be the most potent stimulator of formation and progression of pterygium. Pterygium excision is a common procedure, although the recurrence rates remain high. Various postoperative adjuvant therapies are now attempted to lower the recurrence rate, with severe side effects. To offer a greater therapeutic effect and lower side effects, it's necessary to discover a constant nanoparticle drug delivery targeting to subconjunctival fibroblasts in pterygium (PSFs)...
July 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28684141/anaesthetic-management-of-a-patient-with-multiple-pterygium-syndrome-for-elective-caesarean-section
#5
V Daga, C Mendonca, F Choksey, J Elton, S Radhakrishna
We report a case of a pregnant woman with multiple pterygium syndrome who presented for elective caesarean section. Neuraxial anaesthesia failed and the backup plan of awake intubation was extremely difficult.
April 12, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28674858/self-made-cryopreservative-fibrin-glue-applied-in-pterygium-surgery-a-novel-practical-technique
#6
Jing-Wen Gong, Jun-Hao Chen, Ting Shen, Jin Jiang
PURPOSE: To introduce a novel practical technique of self-made cryopreservative fibrin glue (SMC) applied in pterygium surgery and to assess its safety and efficacy. METHODS: Forty-eight eyes of 48 patients with nasal primary pterygium were enrolled. The patients were equally assigned to 6 groups. Self-made fibrin glue was subpackaged and, respectively, cryopreserved for 3, 7, 15 days and 1, 2 and 3 months. At each time point, the asepsis of SMC was confirmed by bacterial culture and colony counting...
July 3, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28664906/identification-of-pterygium-related-mrna-expression-profiling-by-microarray-analysis
#7
J Liu, X Ding, L Yuan, X Zhang
PurposePterygium is a common degenerative and proliferative disease of the ocular surface. In some severe cases, pterygium may lead to irregular corneal astigmatism and corneal stromal scarring with visual impairment. The proliferative capacities of pterygial cells make them appear similar to tumorigenesis. Although considerable progress has been made towards understanding the etiology of the disease, the pathogenesis of pterygium has not been completely understood. In our previous study, we constructed pterygium-related lncRNA libraries by using microarray to investigate the potential roles of lncRNAs in pterygium...
June 30, 2017: Eye
https://www.readbyqxmd.com/read/28644233/tyrosine-kinase-inhibitor-vatalanib-inhibits-proliferation-and-migration-of-human-pterygial-fibroblasts
#8
Hong Kyu Kim, Ji-Young Choi, Sang Min Park, Chang Rae Rho, Kyong Jin Cho, Sangmee Ahn Jo
PURPOSE: Vatalanib is a small-molecule tyrosine kinase inhibitor. We investigated the effects of vatalanib on the proliferation and migration of cultured human pterygial fibroblasts (HPFs). METHODS: Pterygium tissues were obtained after pterygium excision surgery and subjected to primary culture. HPFs were treated with vatalanib at various concentrations. Mitomycin C (MMC) was used as a positive control. Cell proliferation and migration assays were used to investigate the effects of vatalanib...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28643708/residency-evaluation-and-adherence-design-study-young-ophthalmologists-perception-of-their-residency-programs-clinical-and-surgical-skills
#9
Parikshit Gogate, Partha Biswas, Sundaram Natarajan, Dandapani Ramamurthy, Debashish Bhattacharya, Karl Golnik, Barun Kumar Nayak
BACKGROUND: Residency training is the basis of good clinical and surgical practice. PURPOSE: The aim is to know the demographics, training experience, and perception of young ophthalmologists to improve the present residency programs in India. SETTING: Young ophthalmologists trained in India. METHODS: A survey was conducted by the Academic and Research Committee of the All India Ophthalmology Society, in 2014-2016 of young ophthalmologists (those trained between 2002 and 2012, with 2-10 years' postresidency experience) to gauge teaching of clinical and surgical skills during the postgraduate residency program...
June 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28634544/efficacy-of-subconjunctival-bevacizumab-injections-before-and-after-surgical-excision-in-preventing-pterygium-recurrence
#10
Raffaele Nuzzi, Federico Tridico
PURPOSE: To evaluate the efficacy of subconjunctival bevacizumab injections, before and after surgical excision with bare sclera technique, in preventing postoperative pterygium recurrence. MATERIAL AND METHODS: 83 eyes of 83 patients affected with primary pterygia underwent surgical excision. 42 eyes received two subconjunctival bevacizumab injections, at the dosage of 2.5 mg/0.1 ml, one week prior surgery and one week after intervention. Recurrence rate was evaluated among the two groups...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28624862/comparison-of-autologous-fibrin-glue-versus-nylon-sutures-for-securing-conjunctival-autografting-in-pterygium-surgery
#11
Daryoush Hamidi Alamdari, Mohamad-Reza Sedaghat, Reza Alizadeh, Siamak Zarei-Ghanavati, Hashem Naseri, Fatemeh Sharifi
PURPOSE: To compare the safety, operating time, postoperative ocular signs, symptoms, overall patient satisfaction, complications rate and recurrence rate of autologous fibrin glue (AFG) and nylon suturing (NS) for attaching conjunctival autografts in pterygium surgery. METHODS: A prospective, randomized, interventional study was performed among 120 patients (120 eyes) with primary pterygium. Superior conjunctival autograft was harvested and transferred on to bare sclera after pterygium excision...
June 17, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28623647/expression-of-mtor-in-primary-pterygium-and-its-correlation-with-%C3%AE-smooth-muscle-actin
#12
Xin-Rong Zhao, Ming-Chang Zhang, Hua-Tao Xie, Nan Ji, Xiao-Qiong Ma
PURPOSE: Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that has been shown to affect many cellular functions, such as cell growth, proliferation, and metabolism. However, there has been minimal focus on the expression of mTOR in pterygium. The purpose of this study was to investigate the expression of mTOR and the correlation between the levels of mTOR and α-smooth muscle actin (α-SMA, a marker of transdifferentiation) in pterygium. METHODS: Primary pterygium samples from 28 patients and normal conjunctival samples from 16 patients were surgically removed and analyzed...
June 14, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28622320/a-novel-graft-option-after-pterygium-excision-platelet-rich-fibrin-for-conjunctivoplasty
#13
H B Cakmak, G Dereli Can, M E Can, N Cagil
PurposeTo compare the surgical results, complications, and recurrence rates of primary pterygium excision with conjunctival autografts (CA) vs platelet-rich fibrin (PRF) grafts.Patients and methodsA total of 35 eyes of 35 patients with primary pterygium were included in the study. The patients underwent excision of pterygium followed by closure of the bare sclera by CA (group 1, n=20) vs PRF grafts (group 2, n=15). The PRF was generated from the patients' own whole-blood sample by centrifugation and pressing...
June 16, 2017: Eye
https://www.readbyqxmd.com/read/28614154/regression-of-inflamed-pterygia-by-frequent-high-dose-intralesional-ziv-aflibercept
#14
Ahmad M Mansour
PURPOSE: Intralesional single low-dose vascular endothelial growth factor antagonists have traditionally failed in causing regression of pterygia. The current pilot study investigates the role of high-dose repeated intralesional ziv-aflibercept in causing regression of inflamed or recurring pterygia. METHODS: This prospective study from January 2015 to April 2017 consisted of using high dose of ziv-aflibercept between 0.1 mL (2.5 mg) and 0.3 mL (7.5 mg), depending on the pterygium size and the degree of inflammation...
June 13, 2017: Cornea
https://www.readbyqxmd.com/read/28567165/letter-to-the-editor-corneoscleral-melt-50-years-after-excision-of-pterygium
#15
Aki Kondo, Tatsuya Mimura, Mari Goto, Yuko Kamei, Saito Yusuke, Hiroko Okuma, Masao Matsubara
PURPOSE: To report a case of corneoscleral melt that occurred 50 years after resection of pterygium with postoperative administration of mitomycin C (MMC). RESULTS: A 93-year-old woman developed acute corneal perforation and scleral melt in her left eye at 50 years after pterygium surgery with postoperative topical MMC. She underwent limbal transplantation. The anterior chamber reformed postoperatively and her intraocular pressure was normal. At 12 months after transplantation, best-corrected visual acuity was 20/500 and the graft-host junction was well apposed...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28559202/inhibitory-effects-of-rosmarinic-acid-on-pterygium-epithelial-cells-through-redox-imbalance-and-induction-of-extrinsic-and-intrinsic-apoptosis
#16
Ya-Yu Chen, Chia-Fang Tsai, Ming-Chu Tsai, Yu-Wen Hsu, Fung-Jou Lu
Pterygium is a common tumor-like ocular disease, which may be related to exposure to chronic ultraviolet (UV) radiation. Although the standard treatment for pterygium is surgical intervention, the recurrence rate of pterygium is high when no effective inhibitory drug is used after surgery. Rosmarinic acid (RA) is a polyphenol antioxidant with many biological activities, including anti-UV and anti-tumor properties. This study aimed to examine the inhibitory effects of RA on pterygium epithelial cells (PECs)...
May 27, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28550976/cultivation-and-characterization-of-pterygium-as-an-ex-vivo-study-model-for-disease-and-therapy
#17
Natasha Josifovska, Dóra Júlia Szabó, Richárd Nagymihály, Zoltán Veréb, Andrea Facskó, Ketil Eriksen, Morten C Moe, Goran Petrovski
PURPOSE: Development of ex vivo model to study pathogenesis, inflammation and treatment modalities for pterygium. METHODS: Pterygium obtained from surgery was cultivated (3 months). Gravitational attachment method using viscoelastic facilitated adherence of graft and outgrowing cells. Medium contained serum as the only growth supplement with no use of scaffolds. Surface profiling of the multi-layered cells for hematopoietic- and mesenchymal stem cell markers was performed...
May 24, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28538668/biomechanical-modeling-of-pterygium-radiation-surgery-a-retrospective-case-study
#18
Bojan Pajic, Daniel M Aebersold, Andreas Eggspuehler, Frederik R Theler, Harald P Studer
Pterygium is a vascularized, invasive transformation on the anterior corneal surface that can be treated by Strontium-/Yttrium90 beta irradiation. Finite element modeling was used to analyze the biomechanical effects governing the treatment, and to help understand clinically observed changes in corneal astigmatism. Results suggested that irradiation-induced pulling forces on the anterior corneal surface can cause astigmatism, as well as central corneal flattening. Finite element modeling of corneal biomechanics closely predicted the postoperative corneal surface (astigmatism error -0...
May 24, 2017: Sensors
https://www.readbyqxmd.com/read/28524142/-effectiveness-of-epithelialization-therapy-after-surgical-treatment-of-pterygiu
#19
A V Petraevskiy, K S Trishkin, I A Gndoyan
Pterygium is widely distributed in regions with hot and dry climate. Frequent relapses of the disease are due to delayed epithelialization of postoperative corneal erosion, associated inflammation and formation of dry areas of the cornea. Effective stimulation of corneal epithelium regeneration in the postoperative period could reduce the frequency of relapses. AIM: to compare the effectiveness, safety and tolerability of different keratoprotectors in patients after surgical treatment of pterygium...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28522251/very-long-term-success-of-pterygium-surgery-with-conjunctival-graft
#20
Ofira Zloto, Nachum Rosen, Ari Leshno, Mordechai Rosner
PURPOSE: To examine to the very long term prognosis (16 years in average) of pterygium surgery with superior or inferior conjunctival graft. METHODS: Clinical data for patients that underwent pterygium surgery with conjunctival graft by two surgeons at the Goldschleger Eye Institute, Sheba Medical Center, Israel, between the years 1997-2001 were retrieved from medical records. For all the included patients, data about their eye examinations was summarized and a questionnaire about their eye history was done...
May 15, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
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