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Pterygium

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https://www.readbyqxmd.com/read/28922327/releasable-single-suture-for-primary-pterygium-excision-with-a-conjunctival-autograft
#1
Gautam Singh Parmar, Sachin Arya, Ashok Kumar Meena, Bhushan Ghodke, Elesh Jain, Budhendra Jain
PURPOSE: To evaluate the efficacy of a releasable single suture for pterygium excision with a conjunctival autograft (CAG). METHODS: Retrospective case series at a tertiary eye care center in central India was conducted. Medical records of 150 patients, who underwent primary pterygium excision with a CAG secured by a single releasable 10-0 nylon suture in the last year were reviewed. The surgical duration was noted. The suture was released on the first postoperative day under topical anesthesia...
September 15, 2017: Cornea
https://www.readbyqxmd.com/read/28913510/the-prevalence-and-determinants-of-pterygium-in-rural-areas
#2
Hassan Hashemi, Mehdi Khabazkhoob, Abbasali Yekta, Ebrahim Jafarzadehpour, Hadi Ostadimoghaddam, Haleh Kangari
PURPOSE: To evaluate the prevalence of pterygium and its determinants in the underserved, rural population of Iran. METHODS: In this cross-sectional study of 3851 selected individuals, 86.5% participated in the study, and the prevalence of pterygium was evaluated in 3312 participants. A number of villages were selected from the north and south of Iran using multistage cluster sampling. Pterygium was diagnosed by the ophthalmologist using slit-lamp examination. RESULTS: The mean age of the study participants was 37...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28898113/interferon-regulatory-factor-6-is-necessary-for-salivary-glands-and-pancreas-development
#3
K A Metwalli, M A Do, K Nguyen, S Mallick, K Kin, N Farokhnia, G Jun, W D Fakhouri
Interferon regulatory factor 6 ( IRF6) acts as a tumor suppressor and controls cell differentiation in ectodermal and craniofacial tissues by regulating expression of target genes. Haploinsufficiency of IRF6 causes Van der Woude and popliteal pterygium syndrome, 2 syndromic forms of cleft lip and palate. Around 85% of patients with Van der Woude express pits on the lower lip that continuously or intermittently drain saliva, and patients with the common cleft lip and palate have a higher prevalence of dental caries and gingivitis...
September 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28868833/evaluation-of-interleukin-17-and-interleukin-23-in-pterygium-immunohistochemistry-study
#4
Kiew Ing Tiong, Aida Zairani Mohd Zahidin, S Kala A/P Sumugam, Joseph Uchang, Hazlita Dato' Mohd Isa
PURPOSE: To compare the interleukin-17 (IL-17) and interleukin-23 (IL-23) positive cell counts between pterygium and normal conjunctiva. DESIGN: A case-control study. METHODS: This study received ethical approval (NMRR Research ID 23957) and informed consent was obtained from all participants. It involved 20 participants with 20 samples of pterygium and 20 samples of normal conjunctiva that were obtained from the same eye of each participant...
September 4, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28849159/immunolocalization-of-cannabinoid-receptor-type-1-and-cb2-cannabinoid-receptors-and-transient-receptor-potential-vanilloid-channels-in-pterygium
#5
Martha Assimakopoulou, Dionysios Pagoulatos, Pinelopi Nterma, Nikolaos Pharmakakis
Cannabinoids, as multi‑target mediators, activate cannabinoid receptors and transient receptor potential vanilloid (TRPV) channels. There is evidence to support a functional interaction of cannabinoid receptors and TRPV channels when they are coexpressed. Human conjunctiva demonstrates widespread cannabinoid receptor type 1 (CB1), CB2 and TRPV channel localization. The aim of the present study was to investigate the expression profile for cannabinoid receptors (CB1 and CB2) and TRPV channels in pterygium, an ocular surface lesion originating from the conjunctiva...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28844049/pterygia-are-indicators-of-an-increased-risk-of-developing-cutaneous-melanomas
#6
Julie M Crewe, Tim Threlfall, Antony Clark, Paul G Sanfilippo, David A Mackey
AIM: To investigate whether pterygium is an indicator of an increased risk of cutaneous melanoma (CM). METHODS: A matched-cohort study, using linked health administrative data sets to identify all hospital-treated pterygium in Western Australia (WA) between 1979 and 2014. We identified pterygium cases from hospital diagnosis and/or procedure International Classification of Diseases 9th revision (ICD-9) and 10th revision (ICD-10) codes and matched cases by age, sex and residential postcode to WA Electoral Roll controls with no known history of pterygium...
August 26, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28820155/double-head-pterygium-excision-with-modified-vertically-split-conjunctival-autograft-six-year-long-term-retrospective-analysis
#7
Shreesha Kumar Kodavoor, Dandapani Ramamurthy, Nitin Narendra Tiwari, Shreyas Ramamurthy
PURPOSE: The aim of this study is to describe a modified technique of vertically split-conjunctival autograft (CAG) for primary double-head pterygium and evaluate its postoperative outcome. METHODS: In this retrospective, noncomparative, interventional case series, 87 eyes of 87 patients of double-head pterygium from June 2009 to June 2015 were included. They underwent vertical split CAG. A limbus-limbus orientation was not strictly maintained. Primary outcome measure was recurrence rate...
August 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28807717/myofibroblast-transdifferentiation-the-dark-force-in-ocular-wound-healing-and-fibrosis
#8
REVIEW
Daisy Y Shu, Frank J Lovicu
Wound healing is one of the most complex biological processes to occur in life. Repair of tissue following injury involves dynamic interactions between multiple cell types, growth factors, inflammatory mediators and components of the extracellular matrix (ECM). Aberrant and uncontrolled wound healing leads to a non-functional mass of fibrotic tissue. In the eye, fibrotic disease disrupts the normally transparent ocular tissues resulting in irreversible loss of vision. A common feature in fibrotic eye disease is the transdifferentiation of cells into myofibroblasts that can occur through a process known as epithelial-mesenchymal transition (EMT)...
September 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28803935/tnf-%C3%AE-upregulates-hif-1%C3%AE-expression-in-pterygium-fibroblasts-and-enhances-their-susceptibility-to-vegf-independent-of-hypoxia
#9
Kyoung Woo Kim, Soo Jin Lee, Jae Chan Kim
The clinical manifestations of pterygium are characterized by rapid growth and postoperative recurrences. We had previously proposed that hypoxia-inducible factor (HIF)-1α recruits progenitor cells during the development and progression of pterygia. Recently, it was reported that various stimuli, including inflammation, could activate HIF-1α even under normoxic conditions. The ocular surface directly faces external environments, and is thus frequently exposed to inflammatory insults. First, we examined the gene expression of HIF-1α, its downstream molecule, vascular endothelial growth factor (VEGF)-A, and VEGF receptor (VEGFR)-2 in corneal and conjunctival cells compared with cultured human umbilical vein endothelial cells...
August 10, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28803895/periderm-life-cycle-and-function-during-orofacial-and-epidermal-development
#10
REVIEW
Nigel L Hammond, Jill Dixon, Michael J Dixon
Development of the secondary palate involves a complex series of embryonic events which, if disrupted, result in the common congenital anomaly cleft palate. The secondary palate forms from paired palatal shelves which grow initially vertically before elevating to a horizontal position above the tongue and fusing together in the midline via the medial edge epithelia. As the epithelia of the vertical palatal shelves are in contact with the mandibular and lingual epithelia, pathological fusions between the palate and the mandible and/or the tongue must be prevented...
August 10, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28791059/risk-factors-for-pterygium-in-ilam-province-iran
#11
Parviz Malekifar, Hamed Esfandiari, Nazanin Behnaz, Fatemeh Javadi, Sima Azish, Mohammad Ali Javadi, Masumeh Kalantarion
PURPOSE: To evaluate the risk factors for pterygium in the dry, high altitude province of Ilam, Iran. METHODS: The study included patients who presented to ophthalmology clinic. The patients were divided into two groups: 210 diagnosed with pterygium or pinguecula (unilateral or bilateral), and 210 healthy controls. Demographic variables, living environment, disease type, disease laterality, family history of pterygium as well as history of smoking, working outdoors, baking, welding, ocular conditions (trachoma keratopathy, glaucoma, refractive error, and dry eye), use of glasses, ultraviolet light exposure, and systemic conditions were collected from both groups and compared for risk assessment...
July 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28779179/mtorc1-regulates-apoptosis-and-cell-proliferation-in-pterygium-via-targeting-autophagy-and-fgfr3
#12
Yanli Liu, Hanchun Xu, Meixia An
Pterygium is one of the most common ocular surface diseases. During the initiation of pterygium, resting epithelial cells are activated and exhibit aberrant apoptosis and cell proliferation. Mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth, cell proliferation, protein synthesis, autophagy and transcription. However, the effect of mTORC1 activation in epithelial cells on pterygium development has not yet been reported. Additionally, the roles of mTORC1 in aberrant apoptosis and cell proliferation during the initiation of pterygium, and the underlying mechanisms, are not known...
August 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28770884/outcome-of-application-of-amniotic-membrane-graft-in-ocular-surface-disorders
#13
Nargis Nizam Ashraf, Muhammad Idrees Adhi
OBJECTIVE: To determine the outcome of application of amniotic graft in ocular surface disorders. METHODS: This cross-sectional study was conducted at Dow University of Health Sciences, Karachi, from January 2010 to December 2012, and comprised patients with ocular surface disorders. Patients' presenting symptoms and signs were recorded. Previously harvested and frozen amniotic graft was applied in different types of ocular surface disorders, such as corneal ulcers, pterygium, keratomalacia, Steven-Johnson syndrome, etc...
July 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28760128/analysis-of-musculoskeletal-dysmorphic-abnormalities-of-20-fetuses
#14
Mehmet Nuri Konya, Muhsin Elmas, Çiğdem Özdemir
OBJECTIVES: This study aims to report rates of skeletal abnormalities and their risk factors in light of information obtained in a fetal autopsy series. PATIENTS AND METHODS: The study included 20 fetuses (11 males, 8 females and 1 ambiguous genitalia; mean age 19.3±4.0 weeks; range 16 to 32 week) who underwent autopsy in our hospital between January 2013 and March 2015. Fetuses were systematically classified according to age, gender, family history, abortus week, abortus type, and extremity and organ abnormalities...
August 2017: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/28757691/cut-and-place-technique-of-pterygium-excision-with-autograft-without-using-sutures-or-glue-our-experience
#15
Jagdish Bhatia, Mathew Varghese, Bindu Narayanadas, Arti Bhatia
BACKGROUND: Conjunctival sutures used in pterygium surgery are not only time-consuming process but also may lead to local complications such as discomfort, scarring, granuloma, or infection. Plasma-derived products such as fibrin glue may produce possible hypersensitivity reactions whereas the risk of viral transmission remains theoretically possible. We describe a simple method of achieving conjunctival autograft adherence during pterygium surgery avoiding potential complications associated with the use of fibrin glue or sutures...
May 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28736686/evaluating-changes-in-ocular-redness-using-a-novel-automated-method
#16
Francisco Amparo, Jia Yin, Antonio Di Zazzo, Tulio Abud, Ula V Jurkunas, Pedram Hamrah, Reza Dana
PURPOSE: To evaluate interobserver concordance in measured ocular redness among a group of raters using an objective computer-assisted method (ocular redness index [ORI]) and a group of clinicians using an ordinal comparative scale. METHODS: We conducted a prospective study to evaluate ocular redness in clinical photographs of 12 patients undergoing pterygium surgery. Photographs were acquired preoperatively, and at 1 week and 1 month postoperatively. One group of clinicians graded conjunctival redness in the photographs using an image-based comparative scale...
July 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28734814/conjunctival-autograft-versus-amniotic-membrane-transplantation-for-treatment-of-pterygium-findings-from-a-cochrane-systematic-review
#17
Elizabeth Clearfield, Barbara S Hawkins, Irene C Kuo
No abstract text is available yet for this article.
July 19, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28730117/bevacizumab-as-adjuvant-therapy-in-the-management-of-pterygium-a-systematic-review-and-meta-analysis
#18
Jian Liu, Jie-Hui Xu, Wen Xu, Guan-Lu Liang, Ji-Xian Lou, Yi Wang, Ji-Quan Wen, Yong-Bao Cao
AIM: To evaluate the clinical effect of bevacizumab in pterygium treatment. METHODS: A systematic review and quantitative Meta-analysis was performed. PubMed, EMBASE, Web of Science and Cochrane database were searched for eligible literatures published in English until June 2016. The endpoint was recurrence rate and pooled risk ratio (RR) was calculated. RESULTS: Nine eligible studies were included and Meta-analysis results showed no significantly difference in patients treated with bevacizumab in short term follow-up [3mo: RR=0...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28730091/aberrant-expression-of-genes-and-proteins-in-pterygium-and-their-implications-in-the-pathogenesis
#19
REVIEW
Qing-Yang Feng, Zi-Xuan Hu, Xi-Ling Song, Hong-Wei Pan
Pterygium is a common ocular surface disease induced by a variety of factors. The exact pathogenesis of pterygium remains unclear. Numbers of genes and proteins are discovered in pterygium and they function differently in the occurrence and development of this disease. We searched the Web of Science and PubMed throughout history for literatures about the subject. The keywords we used contain pterygium, gene, protein, angiogenesis, fibrosis, proliferation, inflammation, pathogenesis and therapy. In this review, we summarize the aberrant expression of a range of genes and proteins in pterygium compared with normal conjunctiva or cornea, including growth factors, matrix metalloproteinases and tissue inhibitors of metalloproteinases, interleukins, tumor suppressor genes, proliferation related proteins, apoptosis related proteins, cell adhesion molecules, extracellular matrix proteins, heat shock proteins and tight junction proteins...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28730070/inhibition-effect-of-curcumin-on-uvb-induced-secretion-of-pro-inflammatory-cytokines-from-corneal-limbus-epithelial-cells
#20
Shih-Chun Chao, Dan-Ning Hu, Joan Roberts, Xilun Shen, Chia-Yi Lee, Chan-Wei Nien, Hung-Yu Lin
AIM: To study the effects of curcumin on the secretion of interleukin (IL)-6 and IL-8 by corneal limbus epithelial cells. METHODS: Human corneal limbus epithelial cells were isolated and cultured from donor eyes and irradiated by UVB at different dosages with or without curcumin. MTT test was used for studying the effects of UVB and curcumin on the cell viability. The role of mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) pathways on the UVB-induced secretion of IL-6 and IL-8 were tested by addition of their inhibitors to the culture with or without UVB-radiation...
2017: International Journal of Ophthalmology
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