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Sabahattin Sul, Safak Korkmaz, Goksu Alacamli, Pelin Ozyol, Erhan Ozyol
PURPOSE: The study aims to determine the effect of 50% autologous serum drops (ASD) on corneal healing and patient comfort following pterygium surgery. METHODS: Fifty eyes of 50 patients who underwent pterygium excision combined with autologous conjunctival graft were included in this prospective randomized study: in 25 eyes, 50% ASD. In the remaining 25 eyes, conventional artificial tears (CAT) were applied postoperatively until corneal epithelium had completely epithelialized...
July 18, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Kallirroi Konstantopoulou, Evangelos Tsiambas, Evangelia Baliou, Andreas C Lazaris, Nikolaos Kavantzas, Andreas Karameris, Panagiotis P Fotiades, Ioannis Asproudis, Vasileios Ragos, George Vilaras, Efstratios Patsouris, Kallirroi Konstantopoulou, Evangelos Tsiambas, Evangelia Baliou, Andreas C Lazaris, Nikolaos Kavantzas, Andreas Karameris, Panagiotis P Fotiades, Ioannis Asproudis, Vasileios Ragos, George Vilaras, Efstratios Patsouris
PURPOSE: Pterygium is a distinct clinicopathological entity characterized by degenerated and neoplastic-like features. Concerning its rise on normal conjunctiva epithelia, the role of specific gene deregulations including apoptotic/anti-apoptotic factors and significant suppressor genes in signaling transduction pathways is under investigation. In the current study, we co-analyzed p53, survivin and PTEN proteins in pterygia and normal conjunctiva. METHODS: Using a liquid-based cytology assay, 50 cell specimens were obtained by a smooth scraping on conjunctiva epithelia and fixed accordingly...
May 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Filip Marcinowski
While a student of University in Dorpat (now Tartu, Estonia) Oskar Kobyliński published an article reporting on his 22-year-old patient Leisar Eischikmann, who suffered from a congenital deformity of the neck. Kobyliński described this rare anomaly and called it "flüghautige Verbreitung des Halses" (wing-like extension of the neck). It was only in 1902 when the name pterygium colli was introduced, and it has been in use ever since. This malformation is part of some congenital syndromes, most prominently, Turner syndrome and, more rarely, of Noonan syndrome...
January 1, 2018: Journal of Medical Biography
João Carlos Bezerra Veloso, José Waldo Saraiva Câmara Filho, Maria Isabel Lynch Gaete, Rodrigo Pessoa Cavalcanti Lira
PURPOSE: To identify the frequency of ocular diseases among recipients of disability benefits in the metropolitan region of Recife, Brazil. METHODS: A review was performed of 217,221 cases of disability benefits granted between 2010 and 2015 by the executive managerial department of the Brazilian National Institute of Social Security (Instituto Nacional do Seguro Social [INSS]) in Recife, which encompasses 14 municipalities of the metropolitan region, including the capital...
July 2018: Arquivos Brasileiros de Oftalmologia
Hui-Ya Fan, Zi-Lin Chen
BACKGROUND AND OBJECTIVE: Pterygium has a high recurrence rate after simple excision, and fascial granuloma is one of the common complications of pterygium excision. This study aimed to investigate the treatment for the fascial granuloma. METHODS: In this study, the 36 eyes of 36 cases with fascial granuloma after pterygium excision were collected and divided into two groups to receive granuloma excision and conjunctival autografting or simple granuloma excision...
July 11, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Keiichiro Minami, Tadatoshi Tokunaga, Keiichiro Okamoto, Kazunori Miyata, Tetsuro Oshika
BACKGROUND: The prospective observation study aimed to evaluate changes in corneal higher-order aberrations induced by advancement of pterygium using an anterior-segment optical coherence tomography (AS-OCT) and Zernike aberration analysis. METHODS: The corneal topography of 284 eyes with primary pterygia originating from the nasal region was measured using an AS-OCT (SS-1000, Tomey). With anterior corneal elevation data, Zernike polynomial coefficients were calculated in diameters of 1...
July 9, 2018: BMC Ophthalmology
Mladen Lešin, Martina Paradžik, Josipa Marin Lovrić, Ivana Olujić, Žana Ljubić, Ana Vučinović, Kajo Bućan, Livia Puljak
INTRODUCTION: Pterygium is a non-cancerous growth of the conjunctival tissue over the cornea that may lead to visual impairment in advanced stages, restriction of ocular motility, chronic inflammation and cosmetic concerns. Surgical removal is the treatment of choice, but recurrence of pterygium is a frequent problem. It has been previously shown that fibrin glue may result in less recurrence and may take less time than sutures for fixing the conjunctival graft in place during pterygium surgery...
June 27, 2018: BMJ Open
Xiu-Miao Li, Hui-Min Ge, Jin Yao, Yun-Fan Zhou, Mu-Di Yao, Chang Liu, Hai-Tao Hu, Yun-Xi Zhu, Kun Shan, Biao Yan, Qin Jiang
BACKGROUND/AIMS: Pterygium is a common ocular surface disease with an unknown etiology and threatens vision as it invades into the cornea. Circular RNAs (circRNAs) are a novel class of RNA transcripts that participate in several physiological and pathological processes. However, the role of circRNAs in pathogenesis of pterygium remains largely unknown. METHODS: Genome-wide circRNA expression profiling was performed to identify pterygium -related circRNAs. GO analysis, pathway analysis, and miRNA response elements analysis was performed to predict the function of differentially expressed circRNAs in pterygium...
June 27, 2018: Cellular Physiology and Biochemistry
Lawrence W Hirst, Diana Battistuta
IMPORTANCE: Pterygium is a very common disease in Australia but the statistical data on the provision of pterygium surgical services is poorly understood. BACKGROUND: This study evaluated the trends in the types of surgeries performed for pterygium in Australia over an eight period. DESIGN: Retrospective cross- sectional study PARTICIPANTS: All surgeries performed for pterygium in Australia from 2005 to 2010 in the Medicare system. METHODS: Eight years of Medicare data were analysed for services performed with pterygium removal...
June 26, 2018: Clinical & Experimental Ophthalmology
Ayse Dolar Bilge
Purpose: To investigate and compare the efficacy of conjunctival autograft and conjunctival transpositional flap for the treatment of primary pterygium surgery. Design: Retrospective, interventional case series analysis. Materials and methods: Medical records of 48 patients who underwent pterygium surgery by conjunctival autograft or conjunctival transpositional graft for primary pterygium surgery were reviewed. The conjunctival defects after pterygium excision were repaired in 21 eyes with conjunctival autograft and in 27 eyes with conjunctival transpositional flaps...
April 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Di Cao, Tsz Kin Ng, Yolanda W Y Yip, Alvin L Young, Chi Pui Pang, Wai Kit Chu, Vishal Jhanji
AIMS: To confirm that mouse double minute 2 (MDM2) could inhibit p53 activity in human pterygium. And to show the disruption of MDM2-p53 interaction could reactive the functions of p53 in pterygium. METHOD: Pterygium and corresponding conjunctiva tissues were collected for establishment of primary cell lines. Expression patterns of MDM2 and p53 were detected by immunofluorescence. Protein localization of p53 and MDM2, and transcriptional activity of p53 in both untreated and MDM2 antagonist (Nutlin) treated pterygium cells were quantified...
June 19, 2018: Experimental Eye Research
Santosh Kumar, Roohie Singh
BACKGROUND: Use of conjunctival autograft following excision has reduced the recurrence rate of primary pterygium. This study compares the use of fibrin glue, autologous blood, and sutures in placing the conjunctival autograft in reference to surgical time taken, postoperative discomfort, and recurrence during follow-up. MATERIALS AND METHODS: Sixty patients with primary pterygium were included in the study and divided into three groups. In Group I, autograft was attached in place with help of 10-0 polyamide monofilament suture; in Group II, with autologous blood; and in Group III, with fibrin glue...
May 2018: Oman Journal of Ophthalmology
Daniel R Garźon-Chavez, Emmanuelle Quentin, Simone L Harrison, Alfio V Parisi, Harry J Butler, Nathan J Downs
Tropical Ecuador presents a unique climate in which we study the relationship between the ambient levels of solar ultraviolet radiation and eye disease in the absence of a latitudinal gradient. The national distribution of surface ultraviolet, taking into account MODIS and OMI satellite observation of aerosol, ozone, surface albedo, local elevation and cloud fractions measured during 2011, was compared with the national pterygium (WHO ICD H11) and senile cataract (WHO ICD H25) incidence projected from the 2010 National Institute of Statistics and Census (Ecuador)...
June 21, 2018: Photochemical & Photobiological Sciences
Ka Wai Kam, Anita Li, Rachel Pui Wai Kwok, Michael W Belin, Alvin L Young
PURPOSE: We aim to design two sampling methods, the grid and sectoral methods, to provide more precise detection of focal corneal scar changes with time following pterygium excision with the Pentacam imaging system. METHODS: This is a retrospective study of our previous prospective observational case series. Thirty patients underwent primary pterygium excision with adjuvant topical mitomycin-C application were followed up and imaged with Pentacam system at postoperative weeks 1, 4, 12 and month 18...
June 19, 2018: International Ophthalmology
Ali Kurt, Raşit Kılıç, Murat Tad, Osman Ahmet Polat
PURPOSE: The aim of the study was to evaluate whether YKL-40 (chitinase 3-like 1 protein) plays a role in pterygium pathogenesis. METHODS: We included 42 primary pterygium patients and 24 control subjects with normal bulbar conjunctiva in the study. The pterygium patients were classified into the atrophic, fleshy, and intermediate groups according to the Tan classification. We then surgically removed the primary nasal pterygium and normal bulbar conjunctiva from the patients and immunohistochemically investigated YKL-40 expression...
June 19, 2018: International Ophthalmology
Ricardo D Bennun, Eduardo Stefano, Luis E Moggi
: Van der Woude syndrome is the most generic form of syndromic orofacial cleft, present in approximately 2% of all cleft patients. The lower lip pits with or without cleft lip and/or palate is typical of this syndrome. Popliteal pterygium syndrome (PPS), also known as popliteal web syndrome or fasciogenito-popliteal syndrome, was first described by Trelat in 1869, the incidence is approximately 1 in 300,000 live births. The term PPS was coined by Gorlin et al in 1968 based on the most unusual anomaly, the popliteal pterygium...
June 18, 2018: Journal of Craniofacial Surgery
Youssef A Kousa, Eric Fuller, Brian C Schutte
Variants in IRF6 can lead to Van der Woude Syndrome and Popliteal Pterygium syndrome. Furthermore, genes upstream and downstream of IRF6, including GRHL3 and TP63, are also associated with orofacial clefting. Additionally, a variant in an enhancer (MCS9.7) that regulates IRF6 is associated with risk for isolated orofacial clefting. This variant (rs642961) abrogates AP2A protein binding at MCS9.7. Here, we found that AP2A protein regulates MCS9.7 enhancer activity in vivo and IRF6 protein expression in epidermal development...
June 15, 2018: Journal of Investigative Dermatology
Florian Erger, Karin Burau, Michael Elsässer, Katharina Zimmermann, Ute Moog, Christian Netzer
Complete uniparental isodisomy (iUPD)-the presence of two identical chromosomes in an individual that originate from only a single parental homolog-is an underestimated cause of recessive Mendelian disease in humans. Correctly identifying iUPD in an index patient is of enormous consequence to correctly counseling the family/couple, as the recurrence risk for siblings is reduced from 25% to usually <1%. In medium/large-scale NGS analyses, we found that complete iUPD can be rapidly and straightforwardly inferred from a singleton dataset (index patient only) through a simple chromosome- and genotype-filtering step in <1 min...
June 11, 2018: European Journal of Human Genetics: EJHG
Ho Sik Hwang, Kyong Jin Cho, Gabriel Rand, Roy S Chuck, Ji Won Kwon
BACKGROUND: In our study we describe a method that optimizes size of excision and autografting for primary pterygia along with the use of intraoperative MMC and fibrin glue. Our objective is to propose a simple, optimizedpterygium surgical technique with excellent aesthetic outcomes and low rates of recurrence and otheradverse events. METHODS: Retrospective chart review of 78 consecutive patients with stage III primary pterygia who underwent an optimal excision technique by three experienced surgeons...
June 7, 2018: BMC Ophthalmology
Zongduan Zhang, Zhengwei Yang, Qintuo Pan, Pinyi Chen, Linning Guo
PURPOSE: To measure the incidence and evaluate the clinicopathologic characteristics, surgical outcome, and prognosis of conjunctival granulomas (CGs) after pterygium surgery. METHODS: This was a retrospective review of 3851 pterygium eyes (3330 patients) that underwent pterygium surgery from March 2004 to May 2017. The outcomes were evaluated in 52 eyes (50 patients) that developed CGs after pterygium surgery. RESULTS: CGs developed in 52 of 3851 operated pterygium eyes (1...
August 2018: Cornea
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