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https://www.readbyqxmd.com/read/29144568/kinematic-analysis-of-pressing-situations-in-female-collegiate-football-games-new-insight-into-acl-injury-causation
#1
Shogo Sasaki, Hideyuki Koga, Tron Krosshaug, Satoshi Kaneko, Toru Fukubayashi
The most common events during which anterior cruciate ligament (ACL) injuries occur in football are pressing situations. This study aimed to describe the knee and hip joint kinematics during pressing situations in football games in order to identify kinematic patterns in actions with a high risk for ACL injuries. We filmed 5 female collegiate football matches and identified 66 pressing situations. Five situations with a large distance between the trunk and foot placements in the sagittal plane were analysed using a model-based image-matching technique...
November 16, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29143098/cervicofacial-and-mediastinal-emphysema-after-balloon-eustachian-tuboplasty-bet-a-retrospective-multicenter-analysis
#2
Theodoros Skevas, Carsten V Dalchow, Sara Euteneuer, Holger Sudhoff, Götz Lehnerdt
PURPOSE: Balloon Eustachian tuboplasty (BET) is a new treatment modality addressing chronic obstructive dysfunction of the Eustachian tube (ET). So far, BET has been deemed a safe procedure under general anesthesia with only minor adverse effects. However, individual cases of postoperative emphysema have been reported. In the present retrospective multicenter analysis we determined the incidence rate of this potentially life threatening complication after BET. METHODS: In total we collected data from 3,670 BET procedures performed on 2,272 patients in four tertiary care ENT departments...
November 15, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29140756/cellular-and-molecular-mechanisms-of-autoimmune-hepatitis
#3
G J Webb, G M Hirschfield, E L Krawitt, M E Gershwin
Autoimmune hepatitis is an uncommon idiopathic syndrome of immunemediated destruction of hepatocytes, typically associated with autoantibodies. The disease etiology is incompletely understood but includes a clear association with human leukocyte antigen (HLA) variants and other non- HLA gene variants, female sex, and the environment. Pathologically, there is a CD4+ T cell-rich lymphocytic inflammatory infiltrate with variable hepatocyte necrosis and subsequent hepatic fibrosis. Attempts to understand pathogenesis are informed by several monogenetic syndromes that may include autoimmune liver injury, by several drug and environmental agents that have been identified as triggers in a minority of cases, by human studies that point toward a central role for CD4+ effector and regulatory T cells, and by animal models of the disease...
November 15, 2017: Annual Review of Pathology
https://www.readbyqxmd.com/read/29138799/lychee-seed-extract-protects-against-neuronal-injury-and-improves-cognitive-function-in-rats-with-type-ii-diabetes-mellitus-with-cognitive-impairment
#4
Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qin
Lychee seed is a traditional Chinese medicine and has many beneficial effects such as modulation of blood sugar and lipids, antioxidation, antivirus and antitumor. Studies have indicated that type II diabetes mellitus (T2DM) and Alzheimer's disease (AD) share common biological mechanisms including insulin resistance, impaired glucose metabolism, β‑amyloid (Aβ) formation, oxidative stress and presence of advanced glycation end products (AGEs). The present study investigated the effects of lychee seed extract (LSE) on neuroprotection, cognitive function improvement and possible underlying mechanisms in a rat model of T2DM with cognitive impairment...
November 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29135883/an-analysis-of-the-incidence-and-outcomes-of-major-vs-minor-neurological-decline-after-complex-adult-spinal-deformity-surgery-a-sub-analysis-of-scoli-risk-1-study
#5
So Kato, Michael G Fehlings, Stephen J Lewis, Lawrence G Lenke, Christopher I Shaffrey, Kenneth M C Cheung, Leah Carreon, Mark B Dekutoski, Frank J Schwab, Oheneba Boachie-Adjei, Khaled M Kebaish, Christopher P Ames, Yong Qiu, Yukihiro Matsuyama, Benny T Dahl, Hossein Mehdian, Ferran Pellisé, Sigurd H Berven
STUDY DESIGN: A sub-analysis from a prospective, multicenter, international cohort study in 15 sites (Scoli-RISK-1). OBJECTIVE: To report detailed information regarding the severity of neurological decline related to complex adult spine deformity (ASD) surgery and to examine outcomes based on severity. SUMMARY OF BACKGROUND DATA: The basis of post-operative neurological decline after ASD surgeries can occur due to nerve root(s) or spinal cord dysfunction...
November 10, 2017: Spine
https://www.readbyqxmd.com/read/29135275/the-effects-of-playing-multiple-high-school-sports-on-national-basketball-association-players-propensity-for-injury-and-athletic-performance
#6
Caitlin Rugg, Adarsh Kadoor, Brian T Feeley, Nirav K Pandya
BACKGROUND: Athletes who specialize in their sport at an early age may be at risk for burnout, overuse injury, and reduced attainment of elite status. Timing of sport specialization has not been studied in elite basketball athletes. HYPOTHESIS: National Basketball Association (NBA) players who played multiple sports during adolescence would be less likely to experience injury and would have higher participation rates in terms of games played and career length compared with single-sport athletes...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29132579/the-tragically-hip-trauma-in-elderly-patients
#7
REVIEW
Katrin Hruska, Toralph Ruge
Old age is a risk factor for poor outcome in trauma patients, as a result of undertriage and the presence of occult life-threatening injuries. The mechanisms of injury for geriatric trauma differ from those in younger patients, with a much higher incidence of low-impact trauma, especially falls from a low height. Frailty is a risk factor for severe injury after minor trauma, and caring for these patients require a multidisciplinary team with both trauma and geriatric expertise. With early recognition and aggressive management, severe injuries can still be associated with good outcomes, even in very elderly patients...
February 2018: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/29132141/shoulder-giant-schwannoma-a-diagnosis-to-be-considered-in-painless-shoulder-masses
#8
Romeu Pinho, Sara Santana, Filipa Farinha, Inês Cunha, Anabela Barcelos, José Brenha
Tumours formed from peripheral nerve sheaths are rare in the shoulder. We present the case of a 80-year-old female referred to an orthopaedic surgery clinic because of a large painless mass of the right shoulder, with one year of evolution. There was no history of trauma, involvement of any other joint or systemic complaints. Given the clinical and imagiological suspicion of a giant synovial cyst, the patient underwent complete surgical resection of the mass, which took place without any complications or functional impairment...
November 5, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/29131245/expression-of-the-wnt-%C3%AE-catenin-signal-pathway-in-patients-with-acute-renal-injury
#9
S-Y Wang, S-X Yang, X-X Zhao, F Chen, J Shi
OBJECTIVE: The purpose of this investigation is to determine if the protein expression of the Wnt/β-catenin signal pathway is induced after acute renal injury in patients with acute tubular necrosis. PATIENTS AND METHODS: Sixty patients in who met inclusion criteria underwent renal biopsy. Based on the result of the biopsy, patients were divided into two groups: one with nephrotic syndrome with mini-change disease (MCD group, 30 patients), the other one with minor lesions and acute tubular necrosis (ATN, 30 patients)...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29131132/points-of-concern-in-post-acute-kidney-injury-management
#10
Jill Vanmassenhove, Raymond Vanholder, Norbert Lameire
The incidence of acute kidney injury (AKI) will in the future remain high, partly due to an increase in comorbidities and other AKI favoring factors such as the rise in high-risk diagnostic and therapeutic interventions. AKI has emerged as a major public health concern with high human and financial costs. It has recently been demonstrated that patients surviving an AKI episode show increased all-cause mortality, chronic kidney disease (CKD), ESRD, cardiovascular events, and reduced quality of life. Although it is important to acknowledge that, after an AKI episode, the risk of dying by far exceeds the risk of developing incident or progressive CKD and/or entering a maintenance renal replacement therapy (RRT) program, currently only a minority of patients are referred for renal follow-up, even after AKI-requiring RRT...
November 2, 2017: Nephron
https://www.readbyqxmd.com/read/29127266/injuries-in-female-and-male-elite-taekwondo-athletes-a-10-year-prospective-epidemiological-study-of-1466-injuries-sustained-during-250-000-training-hours
#11
Ki Jun Park, Brian Byung Song
OBJECTIVES: We aimed to determine the injury patterns associated with training activities in elite South Korean taekwondo athletes training for the Olympic Games. METHODS: We collected data prospectively from 2007 to 2016 at the Korea National Training Center in Seoul, South Korea. A sports injury was defined as acute or chronic musculoskeletal signs and symptoms due to taekwondo activities during training sessions. Athletes were assessed by an on-site sports medicine specialist...
November 10, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29126777/graded-photochemical-spinal-cord-injury-results-in-chronic-hyperalgesia-and-depression-like-behaviour-but-no-anxiety-exacerbation-in-female-balb-c-mice
#12
Pere Boadas-Vaello, Judit Homs, Marta Portero-Tresserra, Beltrán Álvarez-Pérez, Meritxell Deulofeu, Enrique Verdú
Neuropathic pain (NP) is present in 40-to-50% of spinal cord injured patients. It tends to chronicity and correlates with lower quality-of-life. Moreover, the role of NP in the eventual exacerbation of anxiety- and depression-like behaviours during its development and chronification in genetically susceptible individuals remains unclear. Thus, although solely few animal models are available, new specific models are needed to complete the array of chances to assay new therapeutic strategies with the aim of treating chronic NT and its associated mood disorders...
November 7, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29125989/prediction-of-mortality-risk-in-victims-of-violent-crimes
#13
Rolf Gedeborg, Bodil Svennblad, Liisa Byberg, Karl Michaëlsson, Ingemar Thiblin
BACKGROUND: To predict mortality risk in victims of violent crimes based on individual injury diagnoses and other information available in health care registries. METHODS: Data from the Swedish hospital discharge registry and the cause of death registry were combined to identify 15,000 hospitalisations or prehospital deaths related to violent crimes. The ability of patient characteristics, injury type and severity, and cause of injury to predict death was modelled using conventional, Lasso, or Bayesian logistic regression in a development dataset and evaluated in a validation dataset...
October 20, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29125177/surgical-management-of-impalement-injuries-to-the-trunk-of-dogs-a-multicentre-retrospective-study
#14
M Matiasovic, Z J Halfacree, A Moores, P Nelissen, S Woods, B Dean, G Chanoit, D C Barnes
OBJECTIVES: To review a large series of dogs referred for treatment of traumatic impalement injuries to the thorax and/or abdomen and to report aetiologies, injury characteristics, management and long-term outcomes. MATERIALS AND METHODS: Previously collected data on dogs that were surgically treated for impalement injuries to the trunk at six veterinary specialist referral institutions in the UK over an 11-year period were reviewed. Data included patient signalment, physiological variables, injury-specific variables, diagnostic imaging reports, surgical procedures undertaken, duration of hospitalisation, antibiotic use, complications and outcomes...
November 10, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29124664/downhill-exercise-alters-immunoproteasome-content-in-mouse-skeletal-muscle
#15
Cory W Baumann, Dongmin Kwak, Deborah A Ferrington, LaDora V Thompson
Content of the immunoproteasome, the inducible form of the standard proteasome, increases in atrophic muscle suggesting it may be associated with skeletal muscle remodeling. However, it remains unknown if the immunoproteasome responds to stressful situations that do not promote large perturbations in skeletal muscle proteolysis. The purpose of this study was to determine how an acute bout of muscular stress influences immunoproteasome content. To accomplish this, wild-type (WT) and immunoproteasome knockout lmp7 (-/-) /mecl1 (-/-) (L7M1) mice were run downhill on a motorized treadmill...
November 9, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29124354/parathyroid-thyroid-and-recurrent-laryngeal-nerve-anatomy-in-an-indian-rhinoceros-rhinoceros-unicornis
#16
R Udelsman, S B Citino, M Prasad, P I Donovan, D V Fredholm
INTRODUCTION: The parathyroid gland was first identified in the Indian rhinoceros in 1849 by Sir Richard Owen. We performed a necropsy in an Indian rhinoceros, recapitulating Owen's dissection and display what appear to be the initial identification of the recurrent laryngeal nerve in situ and the anatomy and histology of the largest rhinoceros parathyroid glands yet identified. MATERIALS AND METHODS: Patrick T. Rhino, a 41-year-old Indian rhinoceros was born in 1974...
November 9, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29122272/enhancing-yoga-participation-a-qualitative-investigation-of-barriers-and-facilitators-to-yoga-among-predominantly-racial-ethnic-minority-low-income-adults
#17
Christine E Spadola, Rebecca Rottapel, Neha Khandpur, Emily Kontos, Suzanne M Bertisch, Dayna A Johnson, Mirja Quante, Sat Bir S Khalsa, Robert B Saper, Susan Redline
Yoga is underutilized among racial/ethnic minorities and low-income populations. To enhance participation among these demographic groups and to inform a future clinical trial, we conducted a qualitative formative investigation, informed by the Social Contextual Model of health behavior change, to identify barriers and facilitators to yoga that could impact study participation. We recruited twenty-four racially/ethnically diverse adults, with and without prior yoga experience, from a low-income, urban housing community to participate in either an individual interview or focus group...
November 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29122116/mipo-of-proximal-humerus-fractures-through-an-anterolateral-acromial-approach-is-the-axillary-nerve-at-risk
#18
Josip Knežević, Mario Mihalj, Fabijan Čukelj, Arsen Ivanišević
PURPOSE: It is known that shoulder surgery may cause iatrogenic injury to the axillary nerve as a serious complication, but there is little evidence to indicate whether the axillary nerve is at risk of injury during an anterolateral acromial approach for minimally-invasive plate osteosynthesis (MIPO) of proximal humerus fractures. We hypothesised that this surgical method is safe for the axillary nerve and would preserve it from iatrogenic injury. MATERIALS AND METHODS: We conducted a prospective follow-up cohort study on 49 consecutive patients with proximal humerus fractures who were managed with MIPO through an anterolateral approach...
November 2017: Injury
https://www.readbyqxmd.com/read/29121655/experimental-blunt-chest-trauma-induced-myocardial-inflammation-and-alteration-of-gap-junction-protein-connexin-43
#19
Miriam Kalbitz, Elisa Maria Amann, Belinda Bosch, Annette Palmer, Anke Schultze, Jochen Pressmar, Birte Weber, Martin Wepler, Florian Gebhard, Hubert Schrezenmeier, Rolf Brenner, Markus Huber-Lang
OBJECTIVE: Severe blunt chest trauma in humans is associated with high mortality rates. Whereas lung tissue damage and lung inflammation after blunt chest trauma have extensively been investigated, the traumatic and posttraumatic effects on the heart remain poorly understood. Therefore, the purpose of this study was to define cardiac injury patterns in an experimental blunt chest trauma model in rats. METHODS: Experimental blunt chest trauma was induced by a blast wave in rats, with subsequent analysis of its effects on the heart...
2017: PloS One
https://www.readbyqxmd.com/read/29119932/relevance-of-cyp2c9-function-in-valproate-therapy
#20
Katalin Monostory, Andrea Nagy, Katalin Toth, Tamas Budi, Adam Kiss, Mate Deri, Gabor Csukly
Genetic polymorphisms of drug metabolizing enzymes can substantially modify the pharmacokinetics of a drug and eventually its efficacy or toxicity; however, inferring a patient's drug metabolizing capacity merely from his or her genotype can lead to false prediction. Non-genetic host factors (age, sex, disease states) and environmental factors (nutrition, co-medication) can transiently alter the enzyme expression and activities resulting in genotype-phenotype mismatch. Although valproic acid is a well-tolerated anticonvulsant, pediatric patients are particularly vulnerable to valproate injury that can be partly attributed to the age-related differences in metabolic pathways...
November 9, 2017: Current Neuropharmacology
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