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https://www.readbyqxmd.com/read/28942078/tau-protein-mapt-as-a-possible-biochemical-marker-of-traumatic-brain-injury-in-postmortem-examination
#1
Mieszko Olczak, Justyna Niderla-Bielińska, Magdalena Kwiatkowska, Dorota Samojłowicz, Sylwia Tarka, Teresa Wierzba-Bobrowicz
MAPT is a neuronal protein that plays an important role in axonal stabilization, neuronal development, and neuronal polarity. MAPT release into the CSF and blood has been interpreted as indicative of axonal injury as its elevated levels were observed in olympic boxers even after a mild head trauma suggesting minor CNS injuries. In our study we wanted to check the potential relevance of MAPT examination for forensic purposes. The study was carried out using cases of head injury group and cases of sudden death (cardiopulmonary failure, no injuries of the head - control group) provided by forensic pathologists at the Department of Forensic Medicine, Medical University of Warsaw...
September 15, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28941139/comparative-outcomes-of-transcatheter-aortic-valve-replacement-in-african-american-and-caucasian-patients-with-severe-aortic-stenosis
#2
Fahad Alqahtani, Sami Aljohani, Ahmad Almustafa, Mohammed Alhijji, Oluseun Ali, David R Holmes, Mohamad Alkhouli
BACKGROUND: Racial disparities in cardiovascular care have been extensively investigated. The introduction of transcatheter aortic valve replacement (TAVR) revolutionized the treatment of aortic stenosis (AS) in the last decade. Whether a racial disparity in the utilization and outcome of TAVR exists is unknown. METHODS: We utilized the nationwide inpatient sample (NIS) to compare utilization rates, and in-hospital outcomes of Caucasians and African American (AA) patients who underwent TAVR between August 2011 and December 2014...
September 23, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28939250/not-every-trauma-patient-with-a-radiographic-head-injury-requires-transfer-for-neurosurgical-evaluation-application-of-the-brain-injury-guidelines-to-patients-transferred-to-a-level-1-trauma-center
#3
Gweniviere Kayla Capron, Mary Beth Voights, Henry R Moore, Derek B Wall
BACKGROUND: Patients with radiographically-identified traumatic brain injury are often transferred to our regional trauma center for neurosurgical evaluation, yet few injuries require neurosurgical intervention. Transfer is costly, inconvenient, and potentially risky in inclement weather. We propose that previously-published brain injury guidelines (BIG)(1) can help to determine which patients could avoid mandatory transfer. METHODS: Retrospective chart review of patients transferred between January 2012 and December 2013 was performed...
September 18, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28938775/effects-of-different-types-of-dark-brooders-on-injurious-pecking-damage-and-production-related-traits-at-rear-and-lay-in-layers
#4
A B Riber, D A Guzman
Injurious pecking (IP) remains one of the major welfare challenges in housing of laying hens worldwide due to the negative consequences it inflicts on animal welfare and economy. One potential solution to reduce IP is the use of dark brooders as the primary heat source during rearing. The objective was to investigate effects of rearing layer chicks with different management strategies and size allowances of dark brooders on IP and production-related traits during rear and lay. Groups of 100 to 103 Isa Warren chicks were reared either with one of 4 brooder types (n = 4 per treatment) or with whole-house heating (control: n = 6)...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28936196/anti-inflammatory-targets-for-the-treatment-of-reperfusion-injury-in-stroke
#5
REVIEW
Atsushi Mizuma, Midori A Yenari
While the mainstay of acute stroke treatment includes revascularization via recombinant tissue plasminogen activator or mechanical thrombectomy, only a minority of stroke patients are eligible for treatment, as delayed treatment can lead to worsened outcome. This worsened outcome at the experimental level has been attributed to an entity known as reperfusion injury (R/I). R/I is occurred when revascularization is delayed after critical brain and vascular injury has occurred, so that when oxygenated blood is restored, ischemic damage is increased, rather than decreased...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28935755/leptin-induces-sca-1-progenitor-cell-migration-enhancing-neointimal-lesions-in-vessel-injury-mouse-models
#6
Yao Xie, Claire M F Potter, Alexandra Le Bras, Witold N Nowak, Wenduo Gu, Shirin Issa Bhaloo, Zhongyi Zhang, Yanhua Hu, Li Zhang, Qingbo Xu
OBJECTIVE: Leptin is an adipokine initially thought to be a metabolic factor. Recent publications have shown its roles in inflammation and vascular disease, to which Sca-1(+) vascular progenitor cells within the vessel wall may contribute. We sought to elucidate the effects of leptin on Sca-1(+) progenitor cells migration and neointimal formation and to understand the underlying mechanisms. APPROACH AND RESULTS: Sca-1(+) progenitor cells from the vessel wall of Lepr(+/+) and Lepr(-/)(-) mice were cultured and purified...
September 21, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28932699/imaging-of-shoulder-instability
#7
REVIEW
Fernando Ruiz Santiago, Alberto Martínez Martínez, Pablo Tomás Muñoz, José Pozo Sánchez, Antonio Zarza Pérez
This extended review tries to cover the imaging findings of the wide range of shoulder injuries secondary to shoulder joint instability. Usefulness of the different imaging methods is stressed, including radiography, computed tomography (CT) and magnetic resonance. The main topics to be covered include traumatic, atraumatic and minor instability syndromes. Radiography may show bone abnormalities associated to instability, including developmental and post-traumatic changes. CT is the best technique depicting and quantifying skeletal changes...
August 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28932127/an-in-vitro-model-of-renal-inflammation-after-ischemic-oxidative-stress-injury-nephroprotective-effects-of-a-hyaluronan-ester-with-butyric-acid-on-mesangial-cells
#8
Olga Baraldi, Francesca Bianchi, Viola Menghi, Andrea Angeletti, Anna Laura Croci Chiocchini, Maria Cappuccilli, Valeria Aiello, Giorgia Comai, Gaetano La Manna
BACKGROUND: Acute kidney injury, known as a major trigger for organ fibrosis and independent predictor of chronic kidney disease, is characterized by mesangial cell proliferation, inflammation and unbalance between biosynthesis and degradation of extracellular matrix. Therapeutic approaches targeting the inhibition of mesangial cell proliferation and matrix expansion may represent a promising opportunity for the treatment of kidney injury. An ester of hyaluronic acid and butyric acid (HB) has shown vasculogenic and regenerative properties in renal ischemic-damaged tissues, resulting in enhanced function recovery and minor degree of inflammation in vivo...
2017: Journal of Inflammation Research
https://www.readbyqxmd.com/read/28930492/time-trends-in-concussion-symptom-presentation-and-assessment-methods-in-high-school-athletes
#9
Dustin W Currie, Matthew J Kraeutler, John B Schrock, Eric C McCarty, R Dawn Comstock
BACKGROUND: Concussion rates have increased significantly over the past decade. This may reflect an increase in the knowledge and diagnosis of the symptoms of a concussion rather than a true increase in the incidence. Assessing trends in the way that concussions are presenting to and being identified by clinicians over the same period may provide additional insight into the apparent rise in concussions. PURPOSE: To evaluate patterns of change in concussion symptom presentation, diagnostic/evaluation methods, and symptom resolution time reported for United States high school athletes from the 2007-2008 through 2014-2015 academic years...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28929807/splenic-artery-embolization-in-blunt-trauma-a-single-center-retrospective-comparison-of-the-use-of-gelatin-sponge-versus-coils
#10
Pasteur Rasuli, Bardia Moosavi, Gordon J French, William Petrcich, Ian Hammond
OBJECTIVE: The purpose of this study was to compare the efficacy of gelatin sponge with that of coils for splenic artery embolization in the treatment of blunt splenic injury. MATERIALS AND METHODS: A single-center retrospective review was performed with the records of 63 patients (45 men, 18 women; mean age, 45.5 years; range, 16-84 years) with blunt splenic injury treated at a tertiary care trauma center by splenic artery embolization with gelatin sponge (n = 30 patients) or metallic coils (n = 33 patients) between 2005 and 2014...
September 20, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28927394/laboratory-markers-of-cardiac-and-metabolic-complications-after-generalized-tonic-clonic-seizures
#11
Robert D Nass, Sina Meiling, René P Andrié, Christian E Elger, Rainer Surges
BACKGROUND: Generalized tonic-clonic seizures (GTCS) frequently lead to emergency inpatient referrals. Laboratory blood values are routinely performed on admission to detect underlying causes and metabolic or cardiac complications. Our goal was to assess the nature and frequency of complications occurring in association with GTCS. METHODS: We retrospectively extracted data from emergency protocols and discharge letters of adult patients admitted to the Department of Epileptology between 01/2010 and 06/2015...
September 19, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28926481/disparities-in-health-care-utilization-of-adults-with-traumatic-brain-injuries-are-related-to-insurance-race-and-ethnicity-a-systematic-review
#12
Shiyao Gao, Raj G Kumar, Stephen R Wisniewski, Anthony Fabio
OBJECTIVE: To characterize racial/ethnic and insurance disparities in the utilization of healthcare services among US adults with traumatic brain injury (TBI). METHODS: The PubMed database was used to search for articles that directly examined the association between race/ethnicity and insurance disparities and healthcare utilization among patients with TBI. Eleven articles that met the criteria and were published between June 2011 and June 2016 were finally included in the review...
September 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28923560/computed-tomography-findings-in-young-children-with-minor-head-injury-presenting-to-the-emergency-department-greater-than-24h-post-injury
#13
Renana Gelernter, Giora Weiser, Eran Kozer
BACKGROUND: Large studies which developed decision rules for the use of Computed tomography (CT) in children with minor head trauma excluded children with late presentation (more than 24h). OBJECTIVE: To assess the prevalence of significant traumatic brain injury (TBI) on CT in infants with head trauma presenting to the emergency department (ED) more than 24h from the injury. METHODS: A retrospective chart review of infants less than 24 months old referred for head CT because of traumatic brain injury from January 2004 to December 2014 in Assaf-Harofeh medical center was conducted...
September 11, 2017: Injury
https://www.readbyqxmd.com/read/28922960/cognitive-performance-in-transient-global-hypoxic-brain-injury-due-to-moderate-drowning
#14
Mariana Penteado Nucci, Katerina Lukasova, Gilson Vieira, João Ricardo Sato, Edson Amaro Júnior
INTRODUCTION: Drowning is a serious and frequently neglected public health threat. Primary respiratory impairment after submersion often leads to brain dysfunction. Depending on the period of global hypoxia (respiratory failure), clinical aspects of neurological dysfunction are evident on the first evaluation after the water rescue. Nowadays, many neuropsychological assessments after drowning are inconclusive, with some studies reporting only minor neurological or cognitive impairments...
September 19, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28922370/ileocolic-resection-is-associated-with-increased-susceptibility-to-injury-in-a-murine-model-of-colitis
#15
Troy Perry, Michael Laffin, Richard N Fedorak, Aducio Thiesen, Bryan Dicken, Karen L Madsen
Ileocolic resection (ICR) is the most common intestinal resection performed for Crohn's disease, with recurrences commonly occurring at the site of the anastomosis. This study used an animal model of ICR in wild-type mice to examine immunologic changes that developed around the surgical anastomosis and how these changes impacted gut responses to minor acute injury. ICR was performed in adult 129S1/SvlmJ mice and results compared with mice receiving sham or no surgery. Dextran sodium sulfate was given either on post-operative day 9 or day 24 to evaluate immune responses in the intestine both immediately following surgery and after a period of healing...
2017: PloS One
https://www.readbyqxmd.com/read/28921622/national-survey-on-managing-minor-childhood-traumatic-head-injuries-in-the-netherlands-shows-low-guideline-adherence-and-large-inter-hospital-variations
#16
Nicky Niele, Lonneke Willemars, Marlies van Houten, Frans B Plötz
More than 12,000 children are seen in Dutch emergency departments with a mild traumatic head injury (MTHI) every year. In The Netherlands, the paediatric MTHI guidelines are primarily based on the Pediatric Emergency Care Applied Research Network study (1). The guidelines define several criteria, based on the patient's age, to help clinicians to decide whether they need to perform a computed tomography (CT) scan (2). This national study determined the adherence to the guidelines and the reasons why clinicians deviated from them...
September 16, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28917584/pneumatoceles-in-pediatric-blunt-trauma-common-and-benign
#17
Lindsey B Armstrong, David P Mooney
INTRODUCTION: Traumatic pneumatoceles are reported to be rare in children and to have an uncertain clinical significance. We report a single institution series of traumatic pneumatoceles to better define their frequency and clinical significance. METHODS: After obtaining approval from the IRB, data were extracted from the trauma registry of a level 1 pediatric trauma center on children diagnosed with a pulmonary contusion (International Classification of Diseases-9th edition diagnosis codes: 861...
August 7, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28910466/surgical-instrument-sets-for-special-operations-expeditionary-surgical-teams
#18
Diane F Hale, Justin C Sexton, Linda C Benavides, Jerry M Benavides, Jonathan B Lundy
BACKGROUND: The deployment of surgical assets has been driven by mission demands throughout years of military operations in Iraq and Afghanistan. The transition to the highly expeditious Golden Hour Offset Surgical Transport Team (GHOST- T) now offers highly mobile surgical assets in nontraditional operating rooms; the content of the surgical instrument sets has also transformed to accommodate this change. METHODS: The 102nd Forward Surgical Team (FST) was attached to Special Operations assigned to southern Afghanistan from June 2015 to March 2016...
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28898867/cerebral-fat-embolism-clinical-presentation-diagnostic-steps-and-long-term-follow-up
#19
Juliane Dunkel, Christian Roth, Frank Erbguth, Wenke Dietrich, Monika Hügens-Penzel, Andreas Ferbert
OBJECTIVE: Symptomatic cerebral fat embolism (CFE) is a rare complication that occurs after a traumatic injury or orthopaedic surgery and is diagnostically challenging. No data is currently available concerning long-term follow-up. METHODS: We identified from medical records 9 patients with CFE and revised the clinical signs and the diagnostic process. We then analysed long-term follow-up data, targeting clinical course after discharge, neurological impairment, and current quality of life, using the Barthel index and the modified Rankin Scale...
2017: European Neurology
https://www.readbyqxmd.com/read/28894892/using-emergency-trauma-team-activations-to-measure-trauma-activity-and-injury-severity-10%C3%A2-years-of-experience-using-an-australian-major-trauma-centre-registry
#20
M M Dinh, S Roncal, K Curtis, R Ivers
OBJECTIVES: To describe the outcomes of Emergency Department trauma team activations over a 10-year period with respect to injury severity and hospital length of stay. METHODS: This was a retrospective study using trauma registry data at a single Major Trauma Centre in Australia. All trauma team activations and arrivals on pre-hospital major trauma (T1) protocol recorded in the trauma registry between June 2006 and July 2016 were included. The outcome of interest was major trauma, defined as an Injury Severity Score (ISS) >12 or length of stay >3 days or requiring urgent operative intervention or admission to the Intensive Care Unit following trauma...
September 11, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
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