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https://www.readbyqxmd.com/read/29323044/magnetic-resonance-imaging-guided-focused-ultrasound-to-increase-localized-blood-spinal-cord-barrier-permeability
#1
Allison H Payne, Gregory W Hawryluk, Yoshimi Anzai, Henrik Odéen, Megan A Ostlie, Ethan C Reichert, Amanda J Stump, Satoshi Minoshima, Donna J Cross
Spinal cord injury (SCI) affects thousands of people every year in the USA, and most patients are left with some permanent paralysis. Therapeutic options are limited and only modestly affect outcome. To address this issue, we used magnetic resonance imaging-guided focused ultrasound (MRgFUS) as a non-invasive approach to increase permeability in the blood-spinal cord barrier (BSCB). We hypothesize that localized, controlled sonoporation of the BSCB by MRgFUS will aid delivery of therapeutics to the injury. Here, we report our preliminary findings for the ability of MRgFUS to increase BSCB permeability in the thoracic spinal cord of a normal rat model...
December 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29322585/scapular-fractures-in-the-pan-scan-era
#2
Cortlyn Brown, Karim Elmobdy, Ali S Raja, Robert M Rodriguez
BACKGROUND: Scapular fractures have been traditionally taught to be associated with significant injuries and major morbidity. As we demonstrated with sternal fracture, pulmonary contusion and rib fracture, increased chest CT utilization and head-to-pelvis CT (pan-scan) protocols in blunt trauma evaluation, however, may diagnose minor, clinically irrelevant scapular fractures, possibly rendering previous teachings obsolete. OBJECTIVES: To determine the 1) percentages of scapular fractures seen on chest CT only (SOCTO) versus seen on both CXR and CT and of isolated scapular fracture (scapular fracture without other thoracic injuries), 2) frequencies of associated thoracic injury with scapular fracture, and 3) proportion of patients admitted, mortality, hospital length of stay, and injury severity scores (ISS), comparing four patient groups: scapular fracture, non-scapular fracture, scapular fracture SOCTO, and isolated scapular fracture...
January 11, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29319016/analysis-of-post-operative-complication-in-single-port-laparoscopic-cholecystectomy-a-retrospective-analysis-in-817-cases-from-a-surgeon
#3
Yongmin Lee, Younghoon Roh, Minchan Kim, Younghoon Kim, Kwanwoo Kim, Sunghwa Kang, Eunjeong Jang
BACKGROUND: Single-port laparoscopic cholecystectomy (SPLC) is a new advanced technique in laparoscopic surgery which has many benefits according to previous reports. The purpose of this study was to present personal experiences with SPLC in> 800 cases performed by a surgeon to evaluate the safety and feasibility of this procedure. MATERIALS AND METHODS: A retrospective review of 817 cases of SPLC was conducted. All patients had received elective SPLC by a surgeon in our centre during March 2009-August 2015...
January 10, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29317223/cluster-analysis-of-vulnerable-groups-in-acute-tbi-rehabilitation
#4
Erkut N Kucukboyaci, Coralynn Long, Michelle Smith, Joseph F Rath, Tamara Bushnik
OBJECTIVE: To analyze the complex relationship between various social indicators that contribute to socioeconomic status and healthcare barriers. DESIGN: Cluster analysis of historical patient data obtained from inpatient visits. SETTING: Setting: Inpatient rehabilitation unit in a large, urban university hospital PARTICIPANTS: Adult patients receiving acute inpatient care, predominantly for closed head injury. INTERVENTIONS: Not applicable MAIN OUTCOME MEASURES: We examined the membership of TBI patients in various "vulnerable group" (VG) clusters (e...
January 6, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29317044/commentary-to-accompany-neurocognitive-assessment-in-minor-traumatic-brain-injury-can-cognitive-evaluation-assist-in-selecting-for-patients-who-require-surveillance-ct-brain-imaging
#5
https://www.readbyqxmd.com/read/29315937/reported-safety-environment-predicts-injuries-among-children-aged-1-6-years-in-specific-communities
#6
Maya Siman-Tov, Kobi Peleg, Orna Baron-Epel
AIM: To measure individual and environmental risk factors predicting reported child injuries. METHODS: A prospective, follow-up study was performed including 380 parents of children aged 1-6 years, living in various communities throughout Israel. Parents were interviewed three times, 3 months apart. Injuries were defined as including minor injuries that required parental attention and medically attended injuries: doctor or nurse visit, emergency medical services or hospitalisation...
January 9, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29310667/wwl70-protects-against-chronic-constriction-injury-induced-neuropathic-pain-in-mice-by-cannabinoid-receptor-independent-mechanisms
#7
Jie Wen, Melissa Jones, Mikiei Tanaka, Prabhuanand Selvaraj, Aviva J Symes, Brian Cox, Yumin Zhang
BACKGROUND: Targeting the endocannabinoid system has emerged as an effective strategy for the treatment of inflammatory and neurological diseases. Unlike the inhibition of the principal 2-arachidonyl glycerol (2-AG) hydrolytic enzyme monoacylglycerol lipase (MAGL), which leads to 2-AG overload and cannabinoid receptor desensitization, selective inhibition of the minor 2-AG hydrolytic enzyme alpha, beta-hydrolase domain 6 (ABHD6) can provide therapeutic benefits without producing cannabimimetic side effects...
January 8, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29305097/the-inter-teres-approach-to-glenoid-neck-fractures-an-alternative-approach-to-glenoid-fixation
#8
Carl W Jones, Vinu M George, Thin F Hong
BACKGROUND: Scapula fractures are rare injuries that are generally treated nonoperatively. When surgery is performed, it is commonly undertaken through the posterior approach, which can be invasive and unforgiving on the soft tissues. We describe an alternative safe approach between teres major and minor that remains deep to a fascial sling formed by the combined infraspinatus and teres minor fasciae and deep to the primary nerve to teres minor, which is a terminal branch of the axillary nerve...
January 2, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29304327/the-use-of-computer-aided-design-and-manufacturing-in-acute-mandibular-trauma-reconstruction
#9
George Kokosis, Edward H Davidson, Rachel Pedreira, Alexandra McMillan, Amir H Dorafshar
PURPOSE: Virtual surgical planning (VSP) with subsequent computer-aided design and manufacturing have proved efficacious in improving the efficiency and outcomes of a plethora of surgical modalities, including mandibular reconstruction and orthognathic surgery. PATIENTS AND METHODS: Five patients underwent complex mandibular reconstruction after traumatic injury using VSP from July 2016 to August 2017 at our institution. The Johns Hopkins University Hospital institutional review board approved the present study...
December 13, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29303450/subcutaneous-bone-flap-storage-after-emergency-craniectomy-cost-effectiveness-and-rate-of-resorption
#10
Griffin Ernst, Fares Qeadan, Andrew P Carlson
OBJECTIVE Decompressive craniectomy is used for uncontrolled intracranial pressure in traumatic brain injury and malignant hemispheric stroke. Subcutaneous preservation of the autologous bone flap in the abdomen is a simple, portable technique but has largely been abandoned due to perceived concerns of resorption. The authors sought to characterize their experience with subcutaneous preservation of the bone flap and cranioplasty. METHODS The authors performed a retrospective single-institution review of subcutaneous preservation of the autologous bone flap after decompressive craniectomy from 2005 to 2015...
January 5, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29301417/isolated-kidney-perfusion-the-influence-of-pulsatile-flow
#11
Charlotte von Horn, Thomas Minor
Within the scope of transplantation research, ex vivo kidney perfusion has been proven an attractive model to study ischemia-reperfusion and preservation injury. Renal perfusion techniques also occupy scientists with the aim to optimize organ reconditioning and preparation prior to transplantation. This study investigated the influence of a pulsatile perfusion pattern that brings flow conditions closer to physiological situations, on renal perfusion characteristic and kidney function in the isolated perfused kidney...
January 4, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29300417/feasibility-acceptability-and-effects-of-a-home-based-exercise-program-using-a-gerontechnology-on-physical-capacities-after-a-minor-injury-in-community-living-older-adults-a-pilot-study
#12
M Lauzé, D D Martel, A Agnoux, M-J Sirois, M Émond, R Daoust, M Aubertin-Leheudre
CONTEXT: Several studies have demonstrated that physical activity can help limit decline in functional capacities of older adults. Nevertheless, many adults aged 65 and over are inactive. OBJECTIVE: To explore the feasibility, the acceptability and the effects of a home-based exercise program (HEP) using a motion capture gerontechnology in independent community-living older adults at risk of function decline. DESIGN: Interventionnal clinical trial...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29294852/the-role-of-the-perceptions-of-school-climate-and-teacher-victimization-by-students
#13
Francis L Huang, Colleen Lloyd Eddy, Emily Camp
Violence directed toward teachers in schools is relatively understudied in comparison with other school-based forms of peer aggression (e.g., school bullying). Based on the nationally representative Schools and Staffing Survey (SASS) 2011-2012, approximately 10% of K-12 public school teachers in the United States, received a threat in the past 12 months and 6% reported being physically attacked. The effects of teacher-directed violence are far reaching and affect not just the victimized teacher, but the larger community itself...
July 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294771/injury-matters-on-female-perpetrated-sex-crimes
#14
Kristen M Budd, David M Bierie
Despite the importance of studying sexual assaults perpetrated by women, the field knows very little about female sexual offenders' (FSOs) use of violence or physical injury resulting from these assaults. This study draws more than 20 years of National Incident-Based Reporting System (NIBRS) data reported to police (1992-2014) to identify factors that distinguish between female perpetrated incidents of sexual assault that result in severe, minor, or no physical victim injuries above and beyond the sexual assault itself...
May 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294655/when-bigger-is-better-household-size-abuse-injuries-neglect-and-family-response-in-novosibirsk-russia
#15
Clifton R Emery, Tatiana Eremina, Carmen Arenas, Jaeyop Kim, Ko Ling Chan
Although previous research has demonstrated larger households to be at higher risk of physical abuse and neglect of children, we argue that unilateral conceptualization of larger households as a risk factor is inappropriate. Application of resource dilution theory must capture the possibility that larger families may have more members with both the agency and will to intervene against child maltreatment. We hypothesized a negative interaction between household size and protective informal social control by family members in predicting abuse injuries and neglect...
February 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29288602/the-types-and-management-of-dental-trauma-during-military-service-in-finland
#16
Atte Antikainen, Pertti Patinen, Jari Päkkilä, Leo Tjäderhane, Vuokko Anttonen
All Finnish males must attend compulsory military service that lasts from six months to one year. About 25 000 males (approximately 80% of each age cohort) and 400 volunteer females complete the service annually. The aim of the study was to investigate the types of dental trauma occurring among Finnish conscripts during their military service. The article also focused on how dental traumas is are treated in the Finnish Defence Forces MATERIAL AND METHODS: All dental records in the Defence Forces' patient register concerning dental trauma during the years 2011 and 2012 were analysed by tooth number, treatment procedures and number of visits RESULTS: According to the patient register, 361 conscripts suffered an oral trauma during their military service; thus, the average annual incidence was 7...
December 30, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/29288352/sublethal-concentration-of-h2o2-enhances-the-protective-effect-of-mesenchymal-stem-cells-in-rat-model-of-spinal-cord-injury
#17
Asrin Rahimi, Iraj Amiri, Amaneh Mohammadi Roushandeh, Zoleikha Golipour Choshali, Zohreh Alizadeh, Tayebeh Artimani, Saeid Afshar, Sara Soleimani Asl
OBJECTIVE: To investigate the effect of H2O2 on the migration and antioxidant defense of mesenchymal stem cells (MSCs) and the neurotrophic effects of H2O2-treated MSCs on spinal cord injury (SCI). RESULTS: Sublethal concentrations of H2O2 decreased cell migration and expression of CXCR4 and CCR2 as well as Nrf2 expression in MSCs. In the second phase, transplantation of treated and untreated MSCs to SCI caused minor changes in locomotor dysfunction. There was a significantly difference between cell-treated and spinal cord injury groups in expression of BDNF (brain-derived neurotrophic factor)...
December 29, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/29286101/-corrigendum-insights-into-the-pathogenesis-of-mycoplasma-pneumoniae-review
#18
Jun He, Mihua Liu, Zhufeng Ye, Tianping Tan, Xinghui Liu, Xiaoxing You, Yanhua Zeng, Yimou Wu
Following the publication of this review, an interested reader alerted us to the fact that a couple of figures had been reproduced from a pair of previous publications without proper acknowledgement of the original source/authors. Figs. 2 and 3, as featured in our review, had originally appeared (with only minor modifications) as Figs. 2 and 4, respectively, in the following articles: Rottem S: Interaction of mycoplasmas with host cells. Physiol Rev 83: 417-32, 2003; and Pilo P, Vilei EM, Peterhans E, Bonvin-Klotz L, Stoffel MH, Dobbelaere D and Frey J: A metabolic enzyme as a primary virulence factor of Mycoplasma mycoides subsp...
December 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29284906/may-heading-in-soccer-result-in-traumatic-brain-injury-a-review-of-literature
#19
REVIEW
Gorazd Bunc, Janez Ravnik, Tomaz Velnar
Background: Globally, soccer is the most popular team sport, unifying many fans all around the world. The epidemiological studies so far have confirmed that head playing and hitting the ball with head may cause minor head injuries, which exert their effects in a cumulative way. Methods: Literature search for this review was conducted and data about traumatic brain injury collected from various sources. Results: The consequences of head injury are evident as chronic changes in cognition, including disturbances in concentration and slowing of mental and physical agility...
October 2017: Medical Archives
https://www.readbyqxmd.com/read/29284248/streptococcus-suis-a-re-emerging-pathogen-associated-with-occupational-exposure-to-pigs-or-pork-products-part-i-epidemiology
#20
Jacek Dutkiewicz, Jacek Sroka, Violetta Zając, Bernard Wasiński, Ewa Cisak, Anna Sawczyn, Anna Kloc, Angelina Wójcik-Fatla
<i>Streptococcus suis</i> (ex Elliot 1966, Kilpper-Bälz & Schleifer 1987) is a facultatively anaerobic Gram-positive ovoid or coccal bacterium surrounded by a polysaccharide capsule. Based on the antigenic diversity of the capsule, <i>S. suis</i> strains are classified serologically into 35 serotypes. <i>Streptococcus suis</i> is a commensal of pigs, commonly colonizing their tonsils and nasal cavities, mostly in weaning piglets between 4-10 weeks of age. This species occurs also in cattle and other mammals, in birds and in humans...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
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