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https://www.readbyqxmd.com/read/29776009/dependence-receptors-the-dark-side-awakens
#1
REVIEW
Ana-Maria Negulescu, Patrick Mehlen
Transmembrane receptors are usually seen as on and off switch: when the specific ligand is bound, the receptor is on and transduces a downstream signal, while when the ligand is absent, the receptor is off. Over the last two decades several reports have argued from an alternative view where some receptors, depending on the context, will be active both in the presence and in the absence of ligand, being sort of onA and onB switch rather than on and off. These receptors have been named Dependence Receptors (DR) and they share the ability to actively trigger cell death when unbound by their respective ligands...
May 18, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29775987/acute-effect-of-interval-walking-on-arterial-stiffness-in-healthy-young-adults
#2
Takanobu Okamoto, Seok-Ki Min, Mikako Sakamaki-Sunaga
The purpose of this study was to determine the acute effects of interval walking (IW) on arterial stiffness. The participants in this study were 14 healthy men and women (age 27.5±3.8 y). Carotid-femoral pulse wave velocity (cfPWV) was measured using an automatic oscillometric device at 30 min before (baseline) and at 30 and 60 min after walking. Participants repeated five sets of 3-min walks at 30% and 70% of maximum aerobic capacity for a total of 6 min per set in the IW trial. The participants also walked for 30 min at 50% (moderate intensity) of maximum aerobic capacity in a continuous walking (CW) trial...
May 18, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29775985/sensorimotor-exercises-and-enhanced-trunk-function-a-randomized-controlled-trial
#3
Steffen Mueller, Tilman Engel, Juliane Mueller, Josefine Stoll, Heiner Baur, Frank Mayer
The aim of this study was to investigate the effect of a 6-week sensorimotor or resistance training on maximum trunk strength and response to sudden, high-intensity loading in athletes.Forty-three healthy, well-trained participants were randomized into sensorimotor (SMT; n=11), resistance training (RT; n=16) and control groups (CG; n=16). Treatment groups received either sensorimotor training (SMT) or resistance training (RT) for 6 weeks, 3 times a week. At baseline and after 6 weeks of intervention, participants' maximum isokinetic strength in trunk rotation and extension was tested (concentric/eccentric 30°/s)...
May 18, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29775958/a-systematic-review-of-community-based-interventions-to-improve-oral-chronic-disease-medication-regimen-adherence-among-individuals-with-substance-use-disorder
#4
REVIEW
Karen M Clements, Tasmina Hydery, Mark A Tesell, Bonnie C Greenwood, Michael C Angelini
BACKGROUND: Poor medication adherence has been shown to cause medical complications, death, and increased healthcare costs and may be of particular importance in patients with substance use disorder (SUD). Concerns regarding adherence in this population may influence a healthcare provider's decision to prescribe a medication requiring high adherence. Guidance defining best practices that promote adherence among individuals with SUD is lacking. METHODS: A review of English articles in Medline and PsycINFO databases, published between October 1, 1994 and October 31, 2017, was conducted in order to identify studies of interventions intended to improve adherence to oral chronic disease medication regimens among patients with SUD...
May 1, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29775957/how-treatment-improvement-in-adhd-and-cocaine-dependence-are-related-to-one-another-a-secondary-analysis
#5
Frances R Levin, C Jean Choi, Martina Pavlicova, John J Mariani, Amy Mahony, Daniel J Brooks, Edward V Nunes, John Grabowski
BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) is overrepresented among individuals seeking treatment for substance use disorders. We previously reported that treatment with extended release mixed amphetamine salts (MAS-XR) increased abstinence, compared to placebo, among patients with co-occurring ADHD and cocaine dependence. This secondary analysis investigates the temporal relationship between ADHD improvement and cocaine abstinence in the first six weeks of the trial...
May 1, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29775954/a-new-methodology-based-on-functional-principal-component-analysis-to-study-postural-stability-post-stroke
#6
M Luz Sánchez-Sánchez, Juan-Manuel Belda-Lois, Silvia Mena-Del Horno, Enrique Viosca-Herrero, Celedonia Igual-Camacho, Beatriz Gisbert-Morant
BACKGROUND: A major goal in stroke rehabilitation is the establishment of more effective physical therapy techniques to recover postural stability. Functional Principal Component Analysis provides greater insight into recovery trends. However, when missing values exist, obtaining functional data presents some difficulties. The purpose of this study was to reveal an alternative technique for obtaining the Functional Principal Components without requiring the conversion to functional data beforehand and to investigate this methodology to determine the effect of specific physical therapy techniques in balance recovery trends in elderly subjects with hemiplegia post-stroke...
May 5, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29775952/molecular-simulation-and-experimental-validation-of-resorcinol-adsorption-on-ordered-mesoporous-carbon-omc
#7
Zaki Uddin Ahmad, Bing Chao, Mas Iwan Konggidinata, Qiyu Lian, Mark E Zappi, Daniel Dianchen Gang
Numerous research works have been devoted in the adsorption area using experimental approaches. All these approaches are based on trial and error process and extremely time consuming. Molecular simulation technique is a new tool that can be used to design and predict the performance of an adsorbent. This research proposed a simulation technique that can greatly reduce the time in designing the adsorbent. In this study, a new Rhombic ordered mesoporous carbon (OMC) model is proposed and constructed with various pore sizes and oxygen contents using Materials Visualizer Module to optimize the structure of OMC for resorcinol adsorption...
April 27, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29775886/sprint-interval-training-sit-substantially-reduces-depressive-symptoms-in-major-depressive-disorder-mdd-a-randomized-controlled-trial
#8
Alice Minghetti, Oliver Faude, Henner Hanssen, Lukas Zahner, Markus Gerber, Lars Donath
Continuous aerobic exercise training (CAT) is considered a complementary treatment option in patients with major depressive disorder (MDD). Intermittent exercise training protocols, such as sprint interval training (SIT) have gained increasing popularity, but no studies on depressive symptoms following SIT in patients with MDD are available. Fifty-nine in-patients with MDD were randomly assigned to a SIT or CAT group. Medication was counterbalanced in both intervention arms. Both intervention groups received 3 weekly training sessions for 4-weeks (12 sessions in total)...
May 8, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29775878/repositioning-of-diabetes-treatments-for-depressive-symptoms-a-systematic-review-and-meta-analysis-of-clinical-trials
#9
REVIEW
Calum D Moulton, Christopher W P Hopkins, Khalida Ismail, Daniel Stahl
Depression is a common comorbidity in diabetes but conventional antidepressant treatments do not consistently improve outcomes. We tested whether established diabetes treatments can also improve depressive symptoms and examined biological correlates of response. We performed a multi-database systematic search of all clinical trials, which measured the effect of licensed diabetes treatments on depressive symptoms using a validated questionnaire. Results of randomised controlled trials (RCT's) were pooled for meta-analysis...
May 7, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29775807/fir-efficacy-safety-and-biomarker-analysis-of-a-phase-ii-open-label-study-of-atezolizumab-in-pd-l1-selected-patients-with-non-small-cell-lung-cancer
#10
David R Spigel, Jamie E Chaft, Scott Gettinger, Bo H Chao, Luc Dirix, Peter Schmid, Laura Q M Chow, Rodney J Hicks, Larry Leon, Jill Fredrickson, Marcin Kowanetz, Alan Sandler, Roel Funke, Naiyer A Rizvi
INTRODUCTION: The FIR phase II study (NCT01846416) evaluated the efficacy and safety of anti-programmed death-ligand 1 (PD-L1) atezolizumab in advanced non-small-cell lung cancer (NSCLC) selected by tumor cell (TC) or tumor-infiltrating immune cell (IC) PD-L1 expression. METHODS: Patients with PD-L1 TC2/3 (PD-L1 staining on ≥5% of TC) or IC2/3 tumors (PD-L1 staining on ≥5% of IC; determined by SP142 PD-L1 immunohistochemistry assay) with paired fresh and archival histology samples were recruited into Cohort 1 (chemotherapy-naïve/>6 months between adjuvant chemotherapy and recurrence), Cohort 2 (≥ second-line without brain metastases), or Cohort 3 (≥ second-line with treated brain metastases)...
May 15, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29775805/new-subsolid-pulmonary-nodules-in-lung-cancer-screening-a-brief-report-of-the-nelson-trial
#11
Joan E Walter, Marjolein A Heuvelmans, Uraujh Yousaf-Khan, Monique D Dorrius, Erik Thunnissen, Anna Schermann, Harry J M Groen, Carlijn M van der Aalst, Kristiaan Nackaerts, Rozemarijn Vliegenthart, Harry J de Koning, Matthijs Oudkerk
INTRODUCTION: Low-dose computed tomography (LDCT) lung cancer screening is recommended in the United States. While new solid nodules after baseline screening have a high lung cancer probability at small size and require lower size cutoff values than baseline nodules, there only is limited evidence on management of new subsolid nodules. METHODS: Within the Dutch-Belgian randomized controlled LDCT lung cancer screening trial (NELSON), 7557 participants underwent baseline screening between April 2004 and December 2006...
May 15, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29775800/insertion-and-presence-of-fine-wire-intramuscular-electrodes-to-the-lumbar-paraspinal-muscles-do-not-affect-muscle-performance-and-activation-during-high-exertion-spinal-extension-activities
#12
Szu-Ping Lee, Jo Armour Smith, Matthew Kimber, Kelsey Houk
BACKGROUND: Low back pain (LBP) is commonly associated with paraspinal muscle dysfunctions. A method to study deep lumbar paraspinal (i.e. multifidus) muscle function and neuromuscular activation pattern is intramuscular electromyography (EMG). Previous studies have shown that the procedure does not significantly impact muscle function during activities involving low-level muscle contractions. However, it is currently unknown how muscular function and activation are affected during high-exertion contractions...
May 15, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29775768/canine-pet-dog-tumor-microsurgery-and-intratumoral-concentration-and-safety-of-metronomic-chlorambucil-for-spontaneous-glioma-a-phase-i-clinical-trial
#13
R Timothy Bentley, Stephanie A Thomovsky, Margaret A Miller, Deborah W Knapp, Aaron A Cohen-Gadol
INTRODUCTION: Metronomic (daily low-dose) chlorambucil requires further study before implementation in human glioma. OBJECTIVE: Investigate the distribution and safety of metronomic chlorambucil in naturally occurring canine glioma. METHODS: Eight client-owned (pet) dogs with newly diagnosed spontaneous glioma were prospectively enrolled. Chlorambucil was administered preoperatively at 4 mg/m2 q 24hr for ≥ 3 days, and continued postoperatively until death or dose-limiting adverse events...
May 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29775741/replacement-of-fishmeal-by-spirulina-arthrospira-platensis-affects-growth-immune-related-gene-expression-in-gibel-carp-carassius-auratus-gibelio-var-cas-iii-and-its-challenge-against-aeromonas-hydrophila-infection
#14
Shenping Cao, Peiyu Zhang, Tao Zou, Shuzhan Fei, Dong Han, Junyan Jin, Haokun Liu, Yunxia Yang, Xiaoming Zhu, Shouqi Xie
The present study examined the effect of dietary spirulina, Arthrospira platensis on growth performance, blood physiological indices, immune-related gene expressions and resistance of juvenile gibel carp against Aeromonas hydrophila infection. Four isonitrogenous (360 g kg-1 ) and isolipidic (90 g kg-1 ) diets were formulated with containing different levels of spirulina powder of 0 g (SP0, the control diet), 3.38 g (SP3.38), 6.76 g (SP6.76) and 13.52 g (SP13.52) per 100 g diet to replace 0%, 25%, 50% and 100% of fishmeal protein, respectively...
May 15, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29775729/can-narrowband-imaging-improve-the-laparoscopic-identification-of-superficial-endometriosis-a-prospective-cohort-trial
#15
Tony Ma, Lenore Ellett, Kate McIlwaine, Janine Manwaring, Alex Eskander, Prathima Chowdary, Emma Readman, Peter Maher
STUDY OBJECTIVE: To assess the utility of narrow band imaging (NBI) to detect additional areas of endometriosis not identified by standard white light in patients undergoing laparoscopy for investigation of pelvic pain. DESIGN: Prospective cohort trial DESIGN CLASSIFICATION: Level II: Evidence obtained from well-designed cohort study. SETTING: Tertiary laparoscopic sub-specialty unit in Melbourne, Australia. PATIENTS: Fifty-seven patients undergoing laparoscopy for investigation of pelvic pain were recruited...
May 15, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29775698/prospective-randomized-controlled-trial-exploring-the-effect-of-tachosil%C3%A2-on-lymphocele-formation-after-extended-pelvic-lymph-node-dissection-in-prostate-cancer
#16
Sarah Buelens, Charles Van Praet, Filip Poelaert, Andries Van Huele, Karel Decaestecker, Nicolaas Lumen
OBJECTIVES: To explore whether TachoSil®, a hemostatic patch, can reduce the incidence of lymphocele formation. Development of a lymphocele is a frequent complication after pelvic lymph node dissection (PLND) for nodal staging in prostate cancer. MATERIALS AND METHODS: From 2013 - 2017, 100 patients with prostate cancer who were set to undergo a staging PLND before external beam radiotherapy (n = 50) or PLND concomitant with radical prostatectomy (RP) (n = 50) were prospectively randomized 1:1 between bilateral TachoSil® placement or not...
May 15, 2018: Urology
https://www.readbyqxmd.com/read/29775688/gyneco-oncological-genomics-and-emerging-biomarkers-for-cancer-treatment-with-immune-checkpoint-inhibitors
#17
REVIEW
Giuseppe Curigliano
In gynecological cancers tumor infiltrating lymphocytes and upregulation of immune-related gene signatures have been associated with a better prognosis. Knowledge of tumor immunogenicity and associated gene signatures suggests that the tumor immune landscape is a key determinant to define patient prognosis and potentially to predict response to immune-checkpoint inhibitors. The aim of this review is to give an overview of immune gene signatures across gynecology histological cancer types, defining their prognostic and potential predictive role...
May 15, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29775662/multivoxel-pattern-similarity-suggests-the-integration-of-temporal-duration-in-hippocampal-event-sequence-representations
#18
Sathesan Thavabalasingam, Edward B O'Neil, Andy C H Lee
Recent rodent work suggests the hippocampus may provide a temporal representation of event sequences, in which the order of events and the interval durations between them are encoded. There is, however, limited human evidence for the latter, in particular whether the hippocampus processes duration information pertaining to the passage of time rather than qualitative or quantitative changes in event content. We scanned participants while they made match/mismatch judgements on each trial between a study sequence of events and a subsequent test sequence...
May 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29775640/prestimulus-delta-and-theta-contributions-to-equiprobable-go-nogo-processing-in-healthy-ageing
#19
Frances M De Blasio, Robert J Barry
Ongoing EEG activity contributes to ERP outcomes of stimulus processing, and each of these measures is known to undergo (sometimes significant) age-related change. Variation in their relationship across the life-span may thus elucidate mechanisms of normal and pathological ageing. This study assessed the relationships between low-frequency EEG prestimulus brain states, the ERP, and behavioural outcomes in a simple equiprobable auditory Go/NoGo paradigm, comparing these for 20 young (Mage  = 20.4 years) and 20 healthy older (Mage  = 68...
May 15, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29775553/influence-of-photobiomodulation-therapy-on-gingivitis-induced-by-multi-bracket-appliances-a-split-mouth-randomized-controlled-trial
#20
Steffen Stein, Michael Schauseil, Andreas Hellak, Heike Korbmacher-Steiner, Andreas Braun
OBJECTIVE: The objective of this split-mouth trial was to investigate the influence of photobiomodulation therapy (PBMT) on adjuvant treatment of gingivitis induced by multi-bracket appliances, after bracket debonding and professional tooth cleaning. MATERIALS AND METHODS: Thirteen patients (mean age 16.15 years; standard deviation ±2.12 years) who had completed active orthodontic treatment with fixed orthodontic appliances in an orthodontic clinic were included on a randomized basis...
May 18, 2018: Photomedicine and Laser Surgery
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