keyword
https://read.qxmd.com/read/38413538/an-op-ed-writing-curriculum-for-medical-students-to-engage-in-advocacy-through-public-writing
#21
JOURNAL ARTICLE
V Ram Krishnamoorthi, Daniel Y Johnson, Spencer Asay, Alexandra Beem, Lahari Vuppaladhadiam, Grace E Keegan, Maeson L Zietowski, Samuel Chen, Shikha Jain, Vineet M Arora
BACKGROUND: Op-ed writing can be a powerful and accessible advocacy tool for physicians, but training is lacking in undergraduate medical education. AIM: To train and engage first-year medical students in op-ed writing. SETTING: Midwestern research-intensive medical school. PARTICIPANTS: All students in a required first-year health policy course in 2021 and 2022. PROGRAM DESCRIPTION: For their health policy course's final assignment, students could opt to write an op-ed on a healthcare issue of their choice...
February 27, 2024: Journal of General Internal Medicine
https://read.qxmd.com/read/38402997/a-novel-deep-learning-based-method-for-automatic-stereology-of-microglia-cells-from-low-magnification-images
#22
JOURNAL ARTICLE
Hunter Morera, Palak Dave, Yaroslav Kolinko, Saeed Alahmari, Aidan Anderson, Grant Denham, Chloe Davis, Juan Riano, Dmitry Goldgof, Lawrence O Hall, G Jean Harry, Peter R Mouton
Microglial cells mediate diverse homeostatic, inflammatory, and immune processes during normal development and in response to cytotoxic challenges. During these functional activities, microglial cells undergo distinct numerical and morphological changes in different tissue volumes in both rodent and human brains. However, it remains unclear how these cytostructural changes in microglia correlate with region-specific neurochemical functions. To better understand these relationships, neuroscientists need accurate, reproducible, and efficient methods for quantifying microglial cell number and morphologies in histological sections...
February 23, 2024: Neurotoxicology and Teratology
https://read.qxmd.com/read/38390029/large-language-models-a-primer-and-gastroenterology-applications
#23
REVIEW
Omer Shahab, Bara El Kurdi, Aasma Shaukat, Girish Nadkarni, Ali Soroush
Over the past year, the emergence of state-of-the-art large language models (LLMs) in tools like ChatGPT has ushered in a rapid acceleration in artificial intelligence (AI) innovation. These powerful AI models can generate tailored and high-quality text responses to instructions and questions without the need for labor-intensive task-specific training data or complex software engineering. As the technology continues to mature, LLMs hold immense potential for transforming clinical workflows, enhancing patient outcomes, improving medical education, and optimizing medical research...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38386895/interpreting-generative-adversarial-networks-to-infer-natural-selection-from-genetic-data
#24
JOURNAL ARTICLE
Rebecca Riley, Iain Mathieson, Sara Mathieson
Understanding natural selection and other forms of non-neutrality is a major focus for the use of machine learning in population genetics. Existing methods rely on computationally intensive simulated training data. Unlike efficient neutral coalescent simulations for demographic inference, realistic simulations of selection typically require slow forward simulations. Because there are many possible modes of selection, a high dimensional parameter space must be explored, with no guarantee that the simulated models are close to the real processes...
February 22, 2024: Genetics
https://read.qxmd.com/read/38384407/detection-of-centroblast-cells-in-h-e-stained-whole-slide-image-based-on-object-detection
#25
JOURNAL ARTICLE
Sumeth Yuenyong, Paisarn Boonsakan, Supasan Sripodok, Peti Thuwajit, Komgrid Charngkaew, Ananya Pongpaibul, Napat Angkathunyakul, Narit Hnoohom, Chanitra Thuwajit
INTRODUCTION: Detection and counting of Centroblast cells (CB) in hematoxylin & eosin (H&E) stained whole slide image (WSI) is an important workflow in grading Lymphoma. Each high power field (HPF) patch of a WSI is inspected for the number of CB cells and compared with the World Health Organization (WHO) guideline that organizes lymphoma into 3 grades. Spotting and counting CBs is time-consuming and labor intensive. Moreover, there is often disagreement between different readers, and even a single reader may not be able to perform consistently due to many factors...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38370012/effects-of-diverse-resistance-training-modalities-on-performance-measures-in-athletes-a-network-meta-analysis
#26
Zhipeng Zhu, Haowen Wu, Longpeng Li, Mingyuan Jia, Dong Li
Background: Jumping ability is one of the necessary qualities for athletes. Previous studies have shown that plyometric training and complex training including plyometrics can improve athletes' jumping ability. With the emergence of various types of complex training, there is uncertainty about which training method has the best effect. This study conducted a meta-analysis of randomized controlled trials of plyometric-related training on athletes' jumping ability, to provide some reference for coaches to design training plans...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38358366/muscular-fitness-profiles-in-relation-to-the-response-in-body-fat-during-school-based-high-intensity-intervention
#27
JOURNAL ARTICLE
Jarosław Domaradzki, Dawid Koźlenia
BACKGROUND: We aimed to assess the equivalence of the muscular fitness (MF) between body fat percentage (BFP) responders (Rs<inf>BFP</inf>) and non-responders (NRs<inf>BFP</inf>) to school-based high-intensity interval training (HIIT). Adolescents aged 16 (N.=73, 42.5% of males) were identified as Rs<inf>BFP</inf> (N.=45) or NRs<inf>BFP</inf> (N.=28). MF was assessed based on hand strength (HS), abdominal muscle strength (ABS), and leg power (VJ)...
February 15, 2024: Journal of Sports Medicine and Physical Fitness
https://read.qxmd.com/read/38357500/impact-of-systemic-hypoxia-and-blood-flow-restriction-on-mechanical-cardiorespiratory-and-neuromuscular-responses-to-a-multiple-set-repeated-sprint-exercise
#28
JOURNAL ARTICLE
Robert Solsona, Roméo Dériaz, Simon Albert, Maxime Chamoux, Jaume Lloria-Varella, Fabio Borrani, Anthony M J Sanchez
Introduction: Repeated sprint cycling exercises (RSE) performed under systemic normobaric hypoxia (HYP) or with blood flow restriction (BFR) are of growing interest. To the best of our knowledge, there is no stringent consensus on the cardiorespiratory and neuromuscular responses between systemic HYP and BFR during RSE. Thus, this study assessed cardiorespiratory and neuromuscular responses to multiple sets of RSE under HYP or with BFR. Methods: According to a crossover design, fifteen men completed RSE (three sets of five 10-s sprints with 20 s of recovery) in normoxia (NOR), HYP, and with bilaterally-cuffed BFR at 45% of resting arterial occlusive pressure during sets in NOR...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38349394/effects-of-school-based-high-intensity-interval-training-on-hemodynamic-parameters-and-heart-rate-variability-a-randomized-controlled-trial
#29
JOURNAL ARTICLE
Sascha Ketelhut, Kerstin Ketelhut, Sebastian R Ketelhut, Reinhard G Ketelhut
Ketelhut, S, Ketelhut, K, Ketelhut, SR, and Ketelhut, RG. Effects of school-based high-intensity interval training on hemodynamic parameters and heart rate variability: A randomized controlled trial. J Strength Cond Res XX(X): 000-000, 2023-The purpose of this study was to assess the effects of a child-specific school-based high-intensity interval training (HIIT) implemented into physical education (PE) classes on various hemodynamic parameters and heart rate variability indices. Forty-six students (age 11 ± 1 year) were randomized into an intervention (INT n = 22) and a control group (CON n = 24)...
February 13, 2024: Journal of Strength and Conditioning Research
https://read.qxmd.com/read/38345430/automated-counting-of-drosophila-imaginal-disc-cell-nuclei
#30
JOURNAL ARTICLE
Pablo Sanchez Bosch, Jeffrey D Axelrod
Automated image quantification workflows have dramatically improved over the past decade, enriching image analysis and enhancing the ability to achieve statistical power. These analyses have proved especially useful for studies in organisms such as Drosophila melanogaster, where it is relatively simple to obtain high sample numbers for downstream analyses. However, the developing wing, an intensively utilized structure in developmental biology, has eluded efficient cell counting workflows due to its highly dense cellular population...
February 12, 2024: Biology Open
https://read.qxmd.com/read/38343424/adherence-to-exercise-after-an-acute-coronary-syndrome-a-6-month-randomized-controlled-trial
#31
JOURNAL ARTICLE
Essi O Saarikoski, Elina T M Roiha, Antti M Kiviniemi, Jose Cerdán-De-Las-Heras, Juha Perkiömäki, Kari S Kaikkonen, Mikko P Tulppo
Introduction: Exercise training with well-known health benefits is a key element in the self-management of coronary artery disease (CAD). Although current guidelines for patients with CAD recommend daily exercise training, most of the patients do not follow the guidelines. We tested the hypothesis that an exercise training program guided by a novel technology used at home will improve adherence to exercise training. Methods: One to three weeks after percutaneous coronary intervention (PCI), acute coronary syndrome patients ( n = 50) were randomized into traditional (age 65 ± 8 years) and novel technology-guided (age 60 ± 8 years) exercise rehabilitation groups...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38335952/effect-of-acute-sodium-bicarbonate-and-caffeine-coingestion-on-repeated-sprint-performance-in-recreationally-trained-individuals-a-randomized-controlled-trial
#32
JOURNAL ARTICLE
Carmen Ferragut, Paola Gonzalo-Encabo, Álvaro López-Samanes, David Valadés, Alberto Pérez-López
INTRODUCTION: The acute and isolated ingestion of sodium bicarbonate (NaHCO3) and caffeine (CAF) improves performance and delays fatigue in high-intensity tasks. However, it remains to be elucidated if the coingestion of both dietary supplements stimulates a summative ergogenic effect. This study aimed to examine the effect of the acute coingestion of NaHCO3 and CAF on repeated-sprint performance. METHODS: Twenty-five trained participants (age: 23.3 [4.0] y; sex [female/male]: 12/13; body mass: 69...
February 9, 2024: International Journal of Sports Physiology and Performance
https://read.qxmd.com/read/38335950/the-day-by-day-periodization-strategies-of-a-giro-d-italia-podium-finisher
#33
JOURNAL ARTICLE
Gabriele Gallo, Manuel Mateo-March, Andrea Fuk, Emanuela Faelli, Piero Ruggeri, Roberto Codella, Luca Filipas
PURPOSE: The aim of this study was to describe the day-by-day training and racing characteristics in preparation for the Giro d'Italia of 1 world-class road cyclist who achieved a place on the podium in the final general classification of the Giro d'Italia. METHODS: Day-by-day power meter training and racing data of 1 study subject (road cyclist; age 25 y; relative maximum oxygen consumption 81 mL·min-1·kg-1; relative 20-min record power output 6...
February 9, 2024: International Journal of Sports Physiology and Performance
https://read.qxmd.com/read/38327462/optimization-of-track-and-field-training-methods-based-on-ssa-bp-and-its-effect-on-athletes-explosive-power
#34
JOURNAL ARTICLE
Ruibin Jing, Zhengwei Wang, Peng Suo
Digitalization and informationization are important trends in the development of the sports industry. The study first introduced the sparrow search algorithm to improve the generalization ability of traditional neural networks, optimizing the assignment of initial weights and thresholds of neural networks; Secondly, the chicken swarm algorithm is introduced to optimize the training combination, period, and intensity of athletes based on the evaluation results, improving the subjective limitations of traditional training methods...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38314561/barriers-to-enrollment-in-a-post-stroke-neuromodulation-and-walking-study-implications-for-recruiting-women
#35
JOURNAL ARTICLE
Twinkle Mehta, Brice Cleland, Sangeetha Madhavan
BACKGROUND: Women have a higher risk of stroke and related disability than men but are underrepresented in stroke clinical trials. Identifying modifiable recruitment and enrollment barriers for women can improve study generalizability, statistical power, and resource utilization. OBJECTIVE: In a post-stroke neuromodulation study, we determined the impact of sex on the occurrence of exclusion criteria and compared the sex distribution of screened and enrolled individuals with a broader stroke-affected population...
February 5, 2024: Neurorehabilitation and Neural Repair
https://read.qxmd.com/read/38301846/high-intensity-interval-training-in-patients-with-intermittent-claudication-a-qualitative-acceptability-study
#36
JOURNAL ARTICLE
Sean Pymer, Amy E Harwood, Saïd Ibeggazene, Gordon McGregor, Chao Huang, Adam R Nicholls, Lee Ingle, Judith Long, Marjorie Rooms, Ian C Chetter, Maureen Twiddy
BACKGROUND: A novel high-intensity interval training (HIIT) program has demonstrated feasibility for patients with intermittent claudication (IC). The aim of this study was to explore patient perspectives of the HIIT program to inform refinement and future research. METHODS: All patients screened and eligible for the 'high intensity interval training in patients with intermittent claudication (INITIATE)' study were eligible to take part in a semistructured interview...
January 30, 2024: Annals of Vascular Surgery
https://read.qxmd.com/read/38299540/phase-diagrams-of-alloys-and-their-hydrides-via-on-lattice-graph-neural-networks-and-limited-training-data
#37
JOURNAL ARTICLE
Matthew D Witman, Norman C Bartelt, Sanliang Ling, Pin-Wen Guan, Lauren Way, Mark D Allendorf, Vitalie Stavila
Efficient prediction of sampling-intensive thermodynamic properties is needed to evaluate material performance and permit high-throughput materials modeling for a diverse array of technology applications. To alleviate the prohibitive computational expense of high-throughput configurational sampling with density functional theory (DFT), surrogate modeling strategies like cluster expansion are many orders of magnitude more efficient but can be difficult to construct in systems with high compositional complexity...
February 1, 2024: Journal of Physical Chemistry Letters
https://read.qxmd.com/read/38282868/predicting-repeat-power-ability-through-common-field-assessments-is-repeat-power-ability-a-unique-physical-quality
#38
JOURNAL ARTICLE
Alex O Natera, Dale W Chapman, Neil D Chapman, Justin W L Keogh
BACKGROUND: The repeat power ability (RPA) assessment is used to test the ability to repeatedly produce maximal ballistic efforts with an external load. The underpinning physical qualities influencing RPA are undetermined. This study aimed to gain further insight into the physical qualities that determine RPA by analysing the association between physical qualities and an assessment of RPA. MATERIALS AND METHODS: Ten well-trained male field hockey players performed an RPA assessment consisting of 20 repetitions of loaded countermovement jumps (LCMJ20), with a percent decrement score of peak power output calculated...
2024: PeerJ
https://read.qxmd.com/read/38260318/pseudo-spectral-angle-mapping-for-automated-pixel-level-analysis-of-highly-multiplexed-tissue-image-data
#39
Madeleine S Durkee, Junting Ai, Gabriel Casella, Thao Cao, Anthony Chang, Ariel Halper-Stromberg, Bana Jabri, Marcus R Clark, Maryellen L Giger
UNLABELLED: The rapid development of highly multiplexed microscopy systems has enabled the study of cells embedded within their native tissue, which is providing exciting insights into the spatial features of human disease [1]. However, computational methods for analyzing these high-content images are still emerging, and there is a need for more robust and generalizable tools for evaluating the cellular constituents and underlying stroma captured by high-plex imaging [2]. To address this need, we have adapted spectral angle mapping - an algorithm used widely in hyperspectral image analysis - to compress the channel dimension of high-plex immunofluorescence images...
January 11, 2024: bioRxiv
https://read.qxmd.com/read/38258831/genetic-associations-with-acceleration-change-of-direction-jump-height-and-speed-in-english-academy-football-players
#40
JOURNAL ARTICLE
Alexander B T McAuley, David C Hughes, Loukia G Tsaprouni, Ian Varley, Bruce Suraci, Ben Bradley, Joseph Baker, Adam J Herbert, Adam L Kelly
McAuley, ABT, Hughes, DC, Tsaprouni, LG, Varley, I, Suraci, B, Bradley, B, Baker, J, Herbert, AJ, and Kelly, AL. Genetic associations with acceleration, change of direction, jump height, and speed in English academy football players. J Strength Cond Res 38(2): 350-359, 2024-High-intensity movements and explosive actions are commonly assessed during athlete development in football (soccer). Although many environmental factors underpin these power-orientated traits, research suggests that there is also a sizeable genetic component...
February 1, 2024: Journal of Strength and Conditioning Research
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