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gadoterate meglumine

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https://www.readbyqxmd.com/read/27925871/no-signal-intensity-increase-in-the-dentate-nucleus-on-unenhanced-t1-weighted-mr-images-after-more-than-20-serial-injections-of-macrocyclic-gadolinium-based-contrast-agents
#1
Alexander Radbruch, Robert Haase, Pascal J Kieslich, Lukas D Weberling, Philipp Kickingereder, Wolfgang Wick, Heinz-Peter Schlemmer, Martin Bendszus
Purpose To determine the effect of more than 20 serial injections of macrocyclic gadolinium-based contrast agents (GBCAs) on the signal intensity (SI) of the dentate nucleus (DN) on unenhanced T1-weighted magnetic resonance (MR) images. Materials and Methods In this retrospective, institutional review board-approved study, 33 patients who underwent at least 20 consecutive MR imaging examinations (plus an additional MR imaging for reference) with the exclusive use of macrocyclic GBCAs gadoterate meglumine and gadobutrol were analyzed...
December 7, 2016: Radiology
https://www.readbyqxmd.com/read/27726239/observational-study-on-the-safety-profile-of-gadoterate-meglumine-in-35-499-patients-the-secure-study
#2
Philippe Soyer, Anthony Dohan, Deepak Patkar, Andreas Gottschalk
PURPOSE: To investigate the safety of gadoterate meglumine and identify the incidence of nephrogenic systemic fibrosis (NSF). MATERIALS AND METHODS: An international prospective observational study was conducted from November 2008 to June 2013. A total of 35,499 adults and children who were scheduled to undergo contrast-enhanced MRI using gadoterate meglumine were analyzed (female, 53.1%; mean age: 49.5 years; range: 0-98 years). At least 3-month follow-up was planned for patients with an estimated creatinine clearance or glomerular filtration rate <60 mL/min (/1...
October 11, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27684794/lack-of-increased-signal-intensity-in-the-dentate-nucleus-after-repeated-administration-of-a-macrocyclic-contrast-agent-in-multiple-sclerosis-an-observational-study
#3
Philipp Eisele, Angelika Alonso, Kristina Szabo, Anne Ebert, Melissa Ong, Stefan O Schoenberg, Achim Gass
Recently, several studies reported increased signal intensity (SI) in the dentate nucleus (DN) after repeated application of gadolinium-based contrast agents (GBCAs), suggesting a deposition of gadolinium in this location. Patients with relapsing-remitting multiple sclerosis (RRMS) frequently show increased permeability of the blood-brain barrier as part of the inflammatory process in the brain parenchyma, which theoretically might increase the risk of gadolinium deposition. In this retrospective study, we investigated a possible increasing SI in the DN after repeated administrations of the macrocyclic contrast agent gadoterate meglumine...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27649101/delayed-gadolinium-enhanced-mr-imaging-of-cartilage-a-comparative-analysis-of-different-gadolinium-based-contrast-agents-in-an-ex-vivo-porcine-model
#4
Yusuhn Kang, Ja-Young Choi, Hye Jin Yoo, Sung Hwan Hong, Heung Sik Kang
Purpose To compare the delayed gadolinium-enhanced magnetic resonance (MR) imaging of cartilage (dGEMRIC) indexes acquired with different gadolinium-based contrast agents (GBCAs), with emphasis on the difference in electrical charge, and to evaluate the feasibility of the use of GBCAs other than gadopentetate dimeglumine with a double negative charge (Gd-DTPA(2-)) as alternatives at dGEMRIC. Materials and Methods Intact porcine patellae (n = 44) were divided into four groups according to GBCA used: Gd-DTPA(2-), double negative gadobenate dimeglumine (Gd-BOPTA(2-)), single negative gadoterate meglumine (Gd-DOTA(-)), and nonionic gadobutrol (Gd-DT-DO3A)...
September 20, 2016: Radiology
https://www.readbyqxmd.com/read/27509544/intravenous-gadoxetate-disodium-administration-reduces-breath-holding-capacity-in-the-hepatic-arterial-phase-a-multi-center-randomized-placebo-controlled-trial
#5
Taylor R McClellan, Utaroh Motosugi, Michael S Middleton, Brian C Allen, Tracy A Jaffe, Chad M Miller, Scott B Reeder, Claude B Sirlin, Mustafa R Bashir
Purpose To determine, in a multicenter double-blinded placebo-controlled trial, whether maximal hepatic arterial phase breath-holding duration is affected by gadoxetate disodium administration. Materials and Methods Institutional review board approval was obtained for this prospective multi-institutional HIPAA-compliant study; written informed consent was obtained from all subjects. At three sites, a total of 44 volunteers underwent a magnetic resonance (MR) imaging examination in which images were acquired before and dynamically after bolus injection of gadoxetate disodium, normal saline, and gadoterate meglumine, administered in random order in a single session...
August 10, 2016: Radiology
https://www.readbyqxmd.com/read/27504794/adverse-reactions-to-gadoterate-meglumine-review-of-over-25-years-of-clinical-use-and-more-than-50-million-doses
#6
Eric de Kerviler, Kenneth Maravilla, Jean-François Meder, Olivier Naggara, Corinne Dubourdieu, Vincent Jullien, Pierre Desché
OBJECTIVE: The aim of this study was to evaluate the safety profile of gadoterate meglumine from clinical trials, postmarketing observational studies, and pharmacovigilance reports of adverse drug reactions (ADRs) encompassing 25 years of clinical use and over 50 million administered doses. MATERIALS AND METHODS: Assessment of the safety of gadoterate meglumine through processing and review of all safety data was collected after magnetic resonance imaging procedures...
September 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27495187/intraindividual-analysis-of-signal-intensity-changes-in-the-dentate-nucleus-after-consecutive-serial-applications-of-linear-and-macrocyclic-gadolinium-based-contrast-agents
#7
Alexander Radbruch, Lukas D Weberling, Pascal J Kieslich, Johanna Hepp, Philipp Kickingereder, Wolfgang Wick, Heinz-Peter Schlemmer, Martin Bendszus
PURPOSE: Recent studies reported an increase in the dentate nucleus (DN)-to-pons signal intensity (SI) ratio (DN-pons SI ratio) on unenhanced T1-weighted images in patients who received consecutive serial injections of linear gadolinium-based contrast agents (GBCAs). In contrast, most studies found no increase in the DN-pons SI ratio when patients were treated with consecutive serial injections of macrocyclic GBCAs. However, the potential difference between macrocyclic and linear GBCAs has never been assessed in individuals who received subsequent applications of both contrast agents...
November 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27373976/effectiveness-of-a-high-relaxivity-contrast-agent-administered-at-half-dose-in-dynamic-susceptibility-contrast-mri-of-brain-gliomas
#8
Girolamo Crisi, Silvano Filice, Gunter Erb, Francesca Bozzetti
PURPOSE: To determine whether half of the approved dose of gadobenate dimeglumine (MultiHance) is as effective as a full dose of gadoterate meglumine (Dotarem) for qualitative and quantitative cerebral blood volume (CBV) perfusion evaluation at 3T in patients with brain gliomas. MATERIALS AND METHODS: We enrolled 65 adult patients in an interindividual comparative study. Patients were randomized to one of two study arms: 33 patients received 0.1 mmol/kg body weight (bw) of gadoterate, 32 patients received 0...
July 4, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27354423/remote-zone-extracellular-volume-and-left-ventricular-remodeling-in-survivors-of-st-elevation-myocardial-infarction
#9
Jaclyn Carberry, David Carrick, Caroline Haig, Samuli M Rauhalammi, Nadeem Ahmed, Ify Mordi, Margaret McEntegart, Mark C Petrie, Hany Eteiba, Stuart Hood, Stuart Watkins, Mitchell Lindsay, Andrew Davie, Ahmed Mahrous, Ian Ford, Naveed Sattar, Paul Welsh, Aleksandra Radjenovic, Keith G Oldroyd, Colin Berry
UNLABELLED: The natural history and pathophysiological significance of tissue remodeling in the myocardial remote zone after acute ST-elevation myocardial infarction (STEMI) is incompletely understood. Extracellular volume (ECV) in myocardial regions of interest can now be measured with cardiac magnetic resonance imaging. Patients who sustained an acute STEMI were enrolled in a cohort study (BHF MR-MI [British Heart Foundation Magnetic Resonance Imaging in Acute ST-Segment Elevation Myocardial Infarction study])...
August 2016: Hypertension
https://www.readbyqxmd.com/read/27276243/hepatic-gadolinium-deposition-and-reversibility-after-contrast-agent-enhanced-mr-imaging-of-pediatric-hematopoietic-stem-cell-transplant-recipients
#10
Natalia Maximova, Massimo Gregori, Floriana Zennaro, Aurelio Sonzogni, Roberto Simeone, Davide Zanon
Purpose To determine if hepatic gadolinium deposition occurs in pediatric patients with iron overload but normal renal and hepatic function who undergo gadolinium-based contrast agent (GBCA)-enhanced magnetic resonance (MR) imaging. Materials and Methods Design and execution of this study was approved by the Ethical Committee of Institute for Research in Maternal and Child Health Burlo Garofolo of Trieste (reference no. 1105/2015). Because of the retrospective nature of the study, the requirement to obtain informed consent was waived...
June 8, 2016: Radiology
https://www.readbyqxmd.com/read/27175546/revisiting-the-pharmacokinetic-profiles-of-gadolinium-based-contrast-agents-differences-in-long-term-biodistribution-and-excretion
#11
Eric Lancelot
OBJECTIVES: Gadolinium-based contrast agents (GBCAs) have been used for years for magnetic resonance imaging examinations. Because of their rapid blood clearance, they were considered as very safe products until some of them were shown to induce nephrogenic systemic fibrosis in patients with renal failure and hypersignals on T1-weighted unenhanced brain scans of patients with normal renal function. To date, these adverse effects have been related almost exclusively to the use of low-stability linear agents, which are more prone to release free gadolinium...
November 2016: Investigative Radiology
https://www.readbyqxmd.com/read/26795351/differences-in-perilymphatic-space-enhancement-and-adverse-inflammatory-reaction-after-intratympanic-injection-of-two-different-gadolinium-agents-a-9-4-t-magnetic-resonance-imaging-study
#12
Mina Park, Ho Sun Lee, Hyeonjin Kim, Seung Ha Oh, Jun Ho Lee, Myung-Whan Suh
PURPOSE: To compare the inner ear enhancement after intratympanic injection of two widely used gadolinium (Gd) agents by 9.4 T micro-magnetic resonance imaging (MRI) and to investigate the effects of Gd on the inner ear. METHODS: Twelve ears of six rats received intratympanic administration of 1/5 diluted Gd agents: gadoterate meglumine (Gd-DTPA) for the left ear and gadodiamide (Gd-DTPA-BMA) for the right ear. MRI was performed every 30 min from 1 to 4 h after administration...
March 2016: Hearing Research
https://www.readbyqxmd.com/read/26606549/linear-gadolinium-based-contrast-agents-are-associated-with-brain-gadolinium-retention-in-healthy-rats
#13
COMPARATIVE STUDY
Philippe Robert, Xavier Violas, Sylvie Grand, Stéphane Lehericy, Jean-Marc Idée, Sébastien Ballet, Claire Corot
OBJECTIVES: The aim of this study was to evaluate Gd retention in the deep cerebellar nuclei (DCN) of linear gadolinium-based contrast agents (GBCAs) compared with a macrocyclic contrast agent. MATERIALS AND METHODS: The brain tissue retention of Gd of 3 linear GBCAs (gadobenate dimeglumine, gadopentetate dimeglumine, and gadodiamide) and a macrocyclic GBCA (gadoterate meglumine) was compared in healthy rats (n = 8 per group) that received 20 intravenous injections of 0...
February 2016: Investigative Radiology
https://www.readbyqxmd.com/read/26606548/signal-increase-on-unenhanced-t1-weighted-images-in-the-rat-brain-after-repeated-extended-doses-of-gadolinium-based-contrast-agents-comparison-of-linear-and-macrocyclic-agents
#14
Gregor Jost, Diana Constanze Lenhard, Martin Andrew Sieber, Jessica Lohrke, Thomas Frenzel, Hubertus Pietsch
OBJECTIVES: In this prospective preclinical study, we evaluated T1-weighted signal intensity in the deep cerebellar nuclei (CN) and globus pallidus (GP) up to 24 days after repeated administration of linear and macrocyclic gadolinium-based contrast agents (GBCAs) using homologous imaging and evaluation methods as in the recently published retrospective clinical studies. In a second part of the study, cerebrospinal fluid (CSF) spaces were evaluated for contrast enhancement by fluid-attenuated magnetic resonance imaging (MRI)...
February 2016: Investigative Radiology
https://www.readbyqxmd.com/read/26382613/non-clinical-safety-assessment-of-gadoterate-meglumine-dotarem-%C3%A2-in-neonatal-and-juvenile-rats
#15
Hervé Giorgi, Jennifer Ammerman, Jean-Paul Briffaux, Nathalie Fretellier, Claire Corot, Philippe Bourrinet
The purpose of this study was to assess the safety of gadoterate meglumine, a gadolinium-based contrast agent used in magnetic resonance imaging, in neonatal and juvenile rats. Rats received a single intravenous administration on postnatal day (PND) 10 or 6 administrations (from PND 10 to 30), at doses of 0, 0.6, 1.25, and 2.5 mmol/kg/administration, i.e. equivalent to approximately 1, 2 and 4-times the usual human dose. The animals were sacrificed at the end of the treatment period or after a 60-day treatment-free period...
December 2015: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/26357497/dynamic-contrast-enhanced-mri-using-a-macromolecular-mr-contrast-agent-p792-evaluation-of-antivascular-drug-effect-in-a-rabbit-vx2-liver-tumor-model
#16
Hee Sun Park, Joon Koo Han, Jeong Min Lee, Young Il Kim, Sungmin Woo, Jung Hwan Yoon, Jin-Young Choi, Byung Ihn Choi
OBJECTIVE: To evaluate the utility of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using macromolecular contrast agent (P792) for assessment of vascular disrupting drug effect in rabbit VX2 liver tumor models. MATERIALS AND METHODS: This study was approved by our Institutional Animal Care and Use Committee. DCE-MRI was performed with 3-T scanner in 13 VX2 liver tumor-bearing rabbits, before, 4 hours after, and 24 hours after administration of vascular disrupting agent (VDA), using gadomelitol (P792, n = 7) or low molecular weight contrast agent (gadoterate meglumine [Gd-DOTA], n = 6)...
September 2015: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/26352749/increased-signal-intensity-in-the-dentate-nucleus-on-unenhanced-t1-weighted-images-after-gadobenate-dimeglumine-administration
#17
Lukas D Weberling, Pascal J Kieslich, Philipp Kickingereder, Wolfgang Wick, Martin Bendszus, Heinz-Peter Schlemmer, Alexander Radbruch
OBJECTIVES: The aim of this study was to compare changes in signal intensity (SI) ratios of the dentate nucleus (DN) to pons and cerebrospinal fluid (CSF) on unenhanced T1-weighted magnetic resonance imaging (MRI) scans between the first and last MRI using the linear gadolinium-based contrast agent gadobenate dimeglumine. MATERIALS AND METHODS: The study was approved by the ethical committee of the University of Heidelberg (S-324/2014), and written informed consent was waived due to the retrospective character of the study...
November 2015: Investigative Radiology
https://www.readbyqxmd.com/read/26185325/the-benefits-of-high-relaxivity-for-brain-tumor-imaging-results-of-a-multicenter-intraindividual-crossover-comparison-of-gadobenate-dimeglumine-with-gadoterate-meglumine-the-benefit-study
#18
RANDOMIZED CONTROLLED TRIAL
M Vaneckova, M Herman, M P Smith, M Mechl, K R Maravilla, J Weichet, M V Spampinato, J Žižka, F J Wippold, J J Baima, R Babbel, E Bültmann, R Y Huang, J-H Buhk, A Bonafé, C Colosimo, S Lui, M A Kirchin, N Shen, G Pirovano, A Spinazzi
BACKGROUND AND PURPOSE: Gadobenate dimeglumine (MultiHance) has higher r1 relaxivity than gadoterate meglumine (Dotarem) which may permit the use of lower doses for MR imaging applications. Our aim was to compare 0.1- and 0.05-mmol/kg body weight gadobenate with 0.1-mmol/kg body weight gadoterate for MR imaging assessment of brain tumors. MATERIALS AND METHODS: We performed crossover, intraindividual comparison of 0.1-mmol/kg gadobenate with 0.1-mmol/kg gadoterate (Arm 1) and 0...
September 2015: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/26123410/mri-in-multiple-sclerosis-an-intra-individual-randomized-and-multicentric-comparison-of-gadobutrol-with-gadoterate-meglumine-at-3-t
#19
RANDOMIZED CONTROLLED TRIAL
Marc Saake, Soenke Langner, Carsten Schwenke, Marina Weibart, Olav Jansen, Norbert Hosten, Arnd Doerfler
OBJECTIVES: To compare contrast effects of gadobutrol with gadoterate meglumine for brain MRI in multiple sclerosis (MS) in a multicentre, randomized, prospective, intraindividual study at 3 T. METHODS: Institutional review board approval was obtained. Patients with known or suspected active MS lesions were included. Two identical MRIs were performed using randomized contrast agent order. Four post-contrast T1 sequences were acquired (start time points 0, 3, 6 and 9 min)...
March 2016: European Radiology
https://www.readbyqxmd.com/read/26107651/t1-weighted-hypersignal-in-the-deep-cerebellar-nuclei-after-repeated-administrations-of-gadolinium-based-contrast-agents-in-healthy-rats-difference-between-linear-and-macrocyclic-agents
#20
Philippe Robert, Stéphane Lehericy, Sylvie Grand, Xavier Violas, Nathalie Fretellier, Jean-Marc Idée, Sébastien Ballet, Claire Corot
OBJECTIVES: To prospectively compare in healthy rats the effect of multiple injections of macrocyclic (gadoterate meglumine) and linear (gadodiamide) gadolinium-based contrast agents (GBCAs) on T1-weighted signal intensity in the deep cerebellar nuclei (DCN), including the dentate nucleus. MATERIALS AND METHODS: Healthy rats (n = 7/group) received 20 intravenous injections of 0.6 mmol of gadolinium (Gd) per kilogram (4 injections per week during 5 weeks) of gadodiamide, gadoterate meglumine, or hyperosmolar saline (control group)...
August 2015: Investigative Radiology
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