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gadoterate meglumine

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https://www.readbyqxmd.com/read/29786486/one-year-retention-of-gadolinium-in-the-brain-comparison-of-gadodiamide-and-gadoterate-meglumine-in-a-rodent-model
#1
Philippe Robert, Stefanie Fingerhut, Cécile Factor, Véronique Vives, Justine Letien, Michael Sperling, Marlène Rasschaert, Robin Santus, Sébastien Ballet, Jean-Marc Idée, Claire Corot, Uwe Karst
Purpose To compare the long-term brain elimination kinetics and gadolinium species in healthy rats after repeated injections of the contrast agents gadodiamide (a linear contrast agent) or gadoterate (a macrocyclic contrast agent). Materials and Methods Nine-week-old rats received five doses of 2.4 mmol gadolinium per kilogram of body weight over 5 weeks and were followed for 12 months with T1-weighted MRI (n = 140 rats, corresponding to seven time points, two contrast agents, and 10 rats per group). Animals were sacrificed at 1 week, 1 month, and 2, 3, 4, 5, and 12 months after the last injection...
May 17, 2018: Radiology
https://www.readbyqxmd.com/read/29737953/gadolinium-distribution-in-cerebrospinal-fluid-after-administration-of-a-gadolinium-based-mr-contrast-agent-in-humans
#2
Florian Berger, Rahel A Kubik-Huch, Tilo Niemann, Hans Ruedi Schmid, Michael Poetzsch, Johannes M Froehlich, Jürg H Beer, Michael J Thali, Thomas Kraemer
Purpose To evaluate whether gadolinium penetrates human cerebrospinal fluid (CSF) after MR imaging (MRI) with a gadolinium-based contrast agent (GBCA). Materials and Methods For this retrospective study, the authors analyzed 60 CSF samples from 57 patients (median age, 50 years; range, 3-92 years) who underwent one contrast material-enhanced MRI examination with gadoterate meglumine within 60 days of CSF extraction between January and December 2016. CSF samples from patients who underwent MRI without contrast material administration (n = 22) or those who underwent contrast-enhanced MRI at least 1 year before extraction (n = 2) were analyzed and used as control samples...
May 8, 2018: Radiology
https://www.readbyqxmd.com/read/29727401/signal-changes-in-the-dentate-nucleus-and-globus-pallidus-on-unenhanced-t1-weighted-magnetic-resonance-images-after-intrathecal-administration-of-macrocyclic-gadolinium-contrast-agent
#3
Kerem Ozturk, Omer Fatih Nas, Esra Soylu, Bahattin Hakyemez
OBJECTIVES: The aim of this study was to evaluate signal changes in the dentate nucleus and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance (MR) images (T1 WI) in a cohort of patients who have received intrathecal macrocyclic ionic gadolinium-based contrast agent (GBCA) gadoterate meglumine. MATERIALS AND METHODS: A group of 20 patients (male/female ratio, 8:12; mean age, 39.5 ± 15.5 years) who had not received intravenous GBCA but had received an intrathecal macrocyclic ionic GBCA (plus baseline and an additional final magnetic resonance imaging [MRI] for reference) from 2012 to 2017 were retrospectively included in this institutional review board-approved study...
April 30, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29713214/single-dose-gadoterate-meglumine-for-3t-late-gadolinium-enhancement-mri-for-the-assessment-of-chronic-myocardial-infarction-intra-individual-comparison-with-conventional-double-dose-1-5t-mri
#4
Jiyeon Lim, Eun-Ah Park, Yong Sub Song, Whal Lee
Objective: To intra-individually compare 3T magnetic resonance (MR) images obtained with one dose gadoterate meglumine to 1.5T MR using conventional double dose for assessment of chronic myocardial infarction. Materials and Methods: Sixteen patients diagnosed with chronic myocardial infarctions were examined on single-dose 3T MR within two weeks after undergoing double-dose 1.5T MR. Representative short-axis images were acquired at three points after administration of gadoterate meglumine...
May 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29680674/multifunctional-hybrid-nanoconstruct-of-zerovalent-iron-and-carbon-dots-for-magnetic-resonance-angiography-and-optical-imaging-an-in-vivo-study
#5
N Nimi, Ariya Saraswathy, Shaiju S Nazeer, Nimmi Francis, Sachin J Shenoy, Ramapurath S Jayasree
In magnetic resonance imaging (MRI), gadolinium (Gd) complexes are very often used as contrast agents to enhance the signal from soft tissue deformities and vascular anomalies, to improve the accuracy of diagnosis. The safety concern of using Gd complexes in renally compromised patients pose limitations on its application. To overcome this scenario, we introduce a nontoxic zerovalent iron based nanoparticle as a novel contrast agent for MR angiography and a hybrid version of the same to serve as a dual function contrast agent for targeted liver imaging...
April 10, 2018: Biomaterials
https://www.readbyqxmd.com/read/29559210/anaphylaxis-after-first-exposure-to-gadoterate-meglumine-a-case-report-and-literature-review
#6
Leonardo Bianchi, Katharina Hansel, Rossella Marietti, Marta Tramontana, Luca Stingeni
No abstract text is available yet for this article.
March 17, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29398574/comparison-of-enhancement-of-the-vestibular-perilymph-between-gadoterate-meglumine-and-gadobutrol-at-3-tesla-in-meniere-s-disease
#7
M Eliezer, G Poillon, A Gillibert, J Horion, Y Cruypeninck, E Gerardin, N Magne, A Attyé
PURPOSE: To compare the degree of enhancement of the perilymph between two macrocyclic gadolinium-based contrast agents (gadobutrol and gadoterate meglumine) in patients with Meniere's disease at 3-T magnetic resonance imaging (MRI). MATERIALS AND METHODS: The MRI examinations of 20 patients with Meniere's disease obtained 4hours after a single intravenous dose of macrocyclic gadolinium-based contrast agents were retrospectively compared. Ten patients (median age: 58...
February 1, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29371404/concurrent-respiratory-motion-correction-of-abdominal-pet-and-dce-mri-using-a-compressed-sensing-approach
#8
Niccolo Fuin, Onofrio Antonio Catalano, Michele Scipioni, Lisanne P W Canjels, David Izquierdo, Stefano Pedemonte, Ciprian Catana
Purpose: We present an approach for concurrent reconstruction of respiratory motion compensated abdominal DCE-MRI and PET data in an integrated PET/MR scanner. The MR and PET reconstructions share the same motion vector fields (MVFs) derived from radial MR data; the approach is robust to changes in respiratory pattern and do not increase the total acquisition time. Methods: PET and DCE-MRI data of 12 oncological patients were simultaneously acquired for 6 minutes on an integrated PET/MR system after administration of 18 F-FDG and gadoterate meglumine...
January 25, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29337841/frequency-and-severity-of-acute-allergic-like-reactions-to-intravenously-administered-gadolinium-based-contrast-media-in-children
#9
Monica M Forbes-Amrhein, Jonathan R Dillman, Andrew T Trout, Bernadette L Koch, Julie M Dickerson, Richard M Giordano, Alexander J Towbin
OBJECTIVES: The purpose of this study is to determine the frequency and severity of acute allergic-like reactions to gadolinium-based contrast media (GBCM) in children before, during, and after the transition from gadopentetate dimeglumine to gadoterate meglumine as our primary clinical GBCM. MATERIALS AND METHODS: Institutional review board approval was obtained for this Health Insurance Portability and Accountability Act-compliant retrospective investigation. Allergic-like reactions to GBCM in pediatric patients were retrospectively assessed from January 2009 to January 2017, which included a departmental change of GBCM from gadopentetate dimeglumine to gadoterate meglumine...
May 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29329151/gadolinium-retention-brain-t1-hyperintensity-and-endogenous-metals-a-comparative-study-of-macrocyclic-versus-linear-gadolinium-chelates-in-renally-sensitized-rats
#10
Marlène Rasschaert, Andréa Emerit, Nathalie Fretellier, Cécile Factor, Philippe Robert, Jean-Marc Idée, Claire Corot
OBJECTIVES: This preclinical study was designed to compare gadolinium (Gd) brain uptake after repeated injections of a macrocyclic Gd-based contrast agent (GBCA) (gadoterate meglumine) or 2 linear GBCAs (L-GBCAs) (gadobenate dimeglumine or gadodiamide) on a translational model of moderate renal impairment in rats. METHODS: The study was carried out in subtotally nephrectomized rats. Animals received 4 intravenous injections per week of GBCA (gadoterate meglumine, gadobenate dimeglumine, or gadodiamide) for 5 weeks, resulting in a cumulative dose of 12 mmol/kg, followed by a 1-month injection-free period...
January 12, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29311709/gadoterate-meglumine-decreases-adc-values-of-breast-lesions-depending-on-the-b-value-combination
#11
Otso Arponen, Mazen Sudah, Anna Sutela, Mikko Taina, Amro Masarwah, Timo Liimatainen, Ritva Vanninen
To retrospectively evaluated the influence of administration of the gadolinium based intravenous contrast agent (G-CA) on apparent diffusion coefficient (ADC) values in ADC maps generated using multiple b value combinations. A total of 106 women underwent bilateral 3.0 T breast MRI. As an internal validation, diffusion-weighted imaging (b values of 0, 200, 400, 600, 800 s/mm2 ) was performed before and after the G-CA (gadoterate meglumine (0.2 ml/kg, 3 ml/s)). Whole lesion and fibroglandular tissue (FGT) covering region-of-interests (ROIs) were drawn on the b = 800 s/mm2 images; ROIs were then propagated to multiple retrospectively generated ADC maps...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29300210/pediatric-brain-gadolinium-deposition-in-dentate-nucleus-and-globus-pallidus-on-unenhanced-t1-weighted-images-is-dependent-on-the-type-of-contrast-agent
#12
Young Jin Ryu, Young Hun Choi, Jung-Eun Cheon, Woo-Jin Lee, Subin Park, Ji Eun Park, Woo Sun Kim, In-One Kim
PURPOSE: The aim of this study was to identify the signal intensity (SI) changes in the dentate nucleus (DN) and the globus pallidus (GP) on unenhanced T1-weighted magnetic resonance (MR) images after multiple administration of gadolinium-based contrast agents (GBCAs) in children and compare those changes between linear and macrocyclic GBCAs. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board and the requirement for informed consent was waived...
April 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29247585/simultaneous-acquisition-of-mr-angiography-and-diagnostic-images-of-abdomen-at-view-sharing-multiarterial-phases-and-comparing-the-effect-of-two-different-contrast-agents
#13
Yoshifumi Noda, Satoshi Goshima, Tomohiro Namimoto, Norihiro Shinkawa, Masataka Nakagawa, Kimihiro Kajita, Hiroshi Kawada, Nobuyuki Kawai, Yukichi Tanahashi, Masayuki Matsuo, Kyongtae T Bae, Toshinori Hirai, Yasuyuki Yamashita
BACKGROUND: Simultaneous acquisition of magnetic resonance angiography (MRA) and diagnostic images is challenging in contrast-enhanced upper abdominal MRI. PURPOSE: To evaluate the image quality of MRA of the abdomen acquired simultaneously with diagnostic MR images, and to compare the contrast effect, conspicuity of aortic branches, and pancreatic lesions in MRA between gadobutrol and gadoterate meglumine. STUDY TYPE: Prospective. POPULATION: Eighty-eight patients with known and suspected upper abdominal disease...
December 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29167070/performance-of-ultrafast-dce-mri-for-diagnosis-of-prostate-cancer
#14
Aritrick Chatterjee, Dianning He, Xiaobing Fan, Shiyang Wang, Teodora Szasz, Ambereen Yousuf, Federico Pineda, Tatjana Antic, Melvy Mathew, Gregory S Karczmar, Aytekin Oto
RATIONALE AND OBJECTIVES: This study aimed to test high temporal resolution dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) for different zones of the prostate and evaluate its performance in the diagnosis of prostate cancer (PCa). Determine whether the addition of ultrafast DCE-MRI improves the performance of multiparametric MRI. MATERIALS AND METHODS: Patients (n = 20) with pathologically confirmed PCa underwent preoperative 3T MRI with T2-weighted, diffusion-weighted, and high temporal resolution (~2...
March 2018: Academic Radiology
https://www.readbyqxmd.com/read/29097910/analytical-interference-by-contrast-agents-in-biochemical-assays
#15
Sigrid Otnes, Niels Fogh-Andersen, Janne Rømsing, Henrik S Thomsen
Objective: To provide a clinically relevant overview of the analytical interference by contrast agents (CA) in laboratory blood test measurements. Materials and Methods: The effects of five CAs, gadobutrol, gadoterate meglumine, gadoxetate disodium, iodixanol, and iomeprol, were studied on the 29 most frequently performed biochemical assays. One-day-old plasma, serum, and whole blood were spiked with doses of each agent such that the gadolinium agents and the iodine agents reached concentrations of 0...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/28956156/absence-of-clinical-cerebellar-syndrome-after-serial-injections-of-more-than-20-doses-of-gadoterate-a-macrocyclic-gbca-a-monocenter-retrospective-study
#16
Gaetano Perrotta, Thierry Metens, Julie Absil, Marc Lemort, Mario Manto
Sound evidence of gadolinium accumulation in brain has been recently provided after repeated administrations of linear gadolinium-based contrast agents (GBCAs), especially at the cerebellum level. Although data regarding brain accumulation of macrocyclic GBCAs are more reassuring, there is now a genuine concern ("gadolinium-phobia") about possible long-term consequences of gadolinium deposits, especially in terms of cerebellar sequelae. We, therefore, questioned about the clinical impact of serial administration of gadoterate meglumine, a macrocyclic GBCA...
November 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28952018/effects-of-serial-macrocyclic-based-contrast-materials-gadoterate-meglumine-and-gadobutrol-administrations-on-gadolinium-related-dentate-nuclei-signal-increases-in-unenhanced-t1-weighted-brain-a-retrospective-study-in-158-multiple-sclerosis-ms-patients
#17
COMPARATIVE STUDY
Alessandra Splendiani, Marco Perri, Claudia Marsecano, Valentina Vellucci, Giulia Michelini, Antonio Barile, Ernesto Di Cesare
PURPOSE: To perform T1 signal intensity (SI) measurements in the dentate nuclei of adult patients with confirmed multiple sclerosis (MS) after serial administrations of the macrocyclic gadolinium-based contrast agents (GBCAs), gadoterate meglumine and gadobutrol. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board and informed consent was waived. A review of our PACS database for the period from March 1, 2007 to July 31, 2016 revealed 158 confirmed MS patients who received exclusively either gadoterate meglumine (n = 81) or gadobutrol (n = 77) for diagnosis and follow-up...
February 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/28915162/the-effect-of-perinatal-gadolinium-based-contrast-agents-on-adult-mice-behavior
#18
Miski Aghnia Khairinisa, Yusuke Takatsuru, Izuki Amano, Khongorzul Erdene, Takahito Nakajima, Satomi Kameo, Hiroshi Koyama, Yoshito Tsushima, Noriyuki Koibuchi
OBJECTIVES: The aim of this study was to examine the effects of perinatal exposure to gadolinium (Gd)-based contrast agents (GBCAs) on the behavior of adulthood offspring. MATERIALS AND METHODS: Pregnant Balb/C mice (n = 5 per group) were intravenously injected with gadoterate meglumine (Magnescope, macrocyclic GBCA), gadodiamide (Omniscan, linear GBCA), or vehicle from pregnancy day 15 to 19, corresponding to embryonic day 15 to 19 of the fetus, at 2 mmol/kg body weight per day...
February 2018: Investigative Radiology
https://www.readbyqxmd.com/read/28906338/a-pharmacokinetics-efficacy-and-safety-study-of-gadoterate-meglumine-in-pediatric-subjects-aged-younger-than-2-years
#19
Mario Scala, Meriam Koob, Sophie de Buttet, Philippe Bourrinet, Mathieu Felices, Elzbieta Jurkiewicz
OBJECTIVES: The primary objective of this study was to investigate the pharmacokinetic profile of gadoterate meglumine in pediatric patients younger than 2 years; the secondary objectives were to document its efficacy and safety. MATERIAL AND METHODS: This was a Phase IV open-label, prospective study conducted in 9 centers (4 countries). Forty-five patients younger than 2 years with normal estimated glomerular filtration rate and scheduled to undergo routine gadolinium-enhanced magnetic resonance imaging (MRI) of any organ were included and received a single intravenous injection of gadoterate meglumine (0...
February 2018: Investigative Radiology
https://www.readbyqxmd.com/read/28864020/pre-clinical-evaluation-of-a-nanoparticle-based-blood-pool-contrast-agent-for-mr-imaging-of-the-placenta
#20
Ketan B Ghaghada, Zbigniew A Starosolski, Saakshi Bhayana, Igor Stupin, Chandreshkumar V Patel, Rohan C Bhavane, Haijun Gao, Andrey Bednov, Chandrasekhar Yallampalli, Michael Belfort, Verghese George, Ananth V Annapragada
INTRODUCTION: Non-invasive 3D imaging that enables clear visualization of placental margins is of interest in the accurate diagnosis of placental pathologies. This study investigated if contrast-enhanced MRI performed using a liposomal gadolinium blood-pool contrast agent (liposomal-Gd) enables clear visualization of the placental margins and the placental-myometrial interface (retroplacental space). Non-contrast MRI and contrast-enhanced MRI using a clinically approved conventional contrast agent were used as comparators...
September 2017: Placenta
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