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https://www.readbyqxmd.com/read/27842678/diagnostic-efficacy-and-safety-of-gadoteric-acid-mr-mammography-in-1537-patients
#1
Tim Seithe, Joachim Braun, Michael Wolf, Janis Vahldiek, Dajana Wolny, Jonas Auer, Joanna Pociej, Oliver Heine, Bernd Hamm, Maximilian de Bucourt
OBJECTIVES: To perform a large-scale multicenter post-marketing surveillance study for analyzing diagnostic effectiveness and safety of intravenous (IV) gadoteric acid (Dotarem(®)) in magnetic resonance (MR) mammography under daily practice conditions. MATERIALS AND METHODS: Patients underwent high-resolution MR mammography with gadoteric acid in 15 German centers. Radiologists used a standardized questionnaire to report data including patient demographics and medical history, characteristics of MR examination and results in terms of diagnosis and safety for the patient...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27711840/a-simple-approach-to-a-new-t8-poss-based-mri-contrast-agent
#2
Helene Strauch, Jörn Engelmann, Klaus Scheffler, Hermann A Mayer
A fast and simple route was developed to synthesize a new T8-silsesquioxane based contrast agent for potential application in Magnetic Resonance Imaging. For this purpose the novel C2-thiol-functionalized T8-silsesquioxane (3) was constructed as a carrier molecule as well as the DOTA based gadolinium(iii) complex (11) equipped with allyl terminated linkers was prepared. The linkage of the complexes to the T8-silsesquioxane was performed via an UV-light catalyzed thiol-ene click reaction within one hour which affords the desired product 13 in a yield of 80%...
September 27, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27652261/immediate-adverse-reactions-to-gadolinium-based-mr-contrast-media-a-retrospective-analysis-on-10-608-examinations
#3
Vincenza Granata, Marco Cascella, Roberta Fusco, Nicoletta dell'Aprovitola, Orlando Catalano, Salvatore Filice, Vincenzo Schiavone, Francesco Izzo, Arturo Cuomo, Antonella Petrillo
Background and Purpose. Contrast media (CM) for magnetic resonance imaging (MRI) may determine the development of acute adverse reactions. Objective was to retrospectively assess the frequency and severity of adverse reactions associated with gadolinium-based contrast agents (GBCAs) injection in patients who underwent MRI. Material and Methods. At our center 10608 MRI examinations with CM were performed using five different GBCAs: Gd-BOPTA (MultiHance), Gd-DTPA (Magnevist), Gd-EOBDTPA (Primovist), Gd-DOTA (Dotarem), and Gd-BTDO3A (Gadovist)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27440634/displacement-of-popliteal-sciatic-nerve-catheters-after-major-foot-and-ankle-surgery-a-randomized-controlled-double-blinded-magnetic-resonance-imaging-study
#4
R W Hauritz, E M Pedersen, F S Linde, K Kibak, J Børglum, S Bjoern, T F Bendtsen
BACKGROUND: Popliteal sciatic nerve catheters (PSNCs) are associated with a high frequency of displacement. We aimed to estimate the frequency of catheter displacement after 48 h with magnetic resonance imaging (MRI) in patients with PSNCs after major foot and ankle surgery randomized to catheter insertion either with a short-axis in-plane (SAX-IP) approach perpendicular to the nerve or with a short-axis out-of-plane (SAX-OOP) approach parallel to the nerve. METHODS: Forty patients were randomly allocated to SAX-IP or SAX-OOP PSNC...
August 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27373976/effectiveness-of-a-high-relaxivity-contrast-agent-administered-at-half-dose-in-dynamic-susceptibility-contrast-mri-of-brain-gliomas
#5
Girolamo Crisi, Silvano Filice, Gunter Erb, Francesca Bozzetti
PURPOSE: To determine whether half of the approved dose of gadobenate dimeglumine (MultiHance) is as effective as a full dose of gadoterate meglumine (Dotarem) for qualitative and quantitative cerebral blood volume (CBV) perfusion evaluation at 3T in patients with brain gliomas. MATERIALS AND METHODS: We enrolled 65 adult patients in an interindividual comparative study. Patients were randomized to one of two study arms: 33 patients received 0.1 mmol/kg body weight (bw) of gadoterate, 32 patients received 0...
July 4, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27113247/t1-weighted-mr-imaging-of-liver-tumor-by-gadolinium-encapsulated-glycol-chitosan-nanoparticles-without-non-specific-toxicity-in-normal-tissues
#6
Jin Hee Na, Sangmin Lee, Heebeom Koo, Hyounkoo Han, Kyung Eun Lee, Seung Jin Han, Seung Hong Choi, Hyuncheol Kim, Seulki Lee, Ick Chan Kwon, Kuiwon Choi, Kwangmeyung Kim
Herein, we have synthesized Gd(iii)-encapsulated glycol chitosan nanoparticles (Gd(iii)-CNPs) for tumor-targeted T1-weighted magnetic resonance (MR) imaging. The T1 contrast agent, Gd(iii), was successfully encapsulated into 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-modified CNPs to form stable Gd(iii)-encapsulated CNPs (Gd(iii)-CNPs) with an average particle size of approximately 280 nm. The stable nanoparticle structure of Gd(iii)-CNPs is beneficial for liver tumor accumulation by the enhanced permeation and retention (EPR) effect...
May 5, 2016: Nanoscale
https://www.readbyqxmd.com/read/26403358/the-effect-of-gd-on-trityl-based-dynamic-nuclear-polarisation-in-solids
#7
Enrico Ravera, Daphna Shimon, Akiva Feintuch, Daniella Goldfarb, Shimon Vega, Alessandra Flori, Claudio Luchinat, Luca Menichetti, Giacomo Parigi
In dynamic nuclear polarisation (DNP) experiments performed under static conditions at 1.4 K we show that the presence of 1 mM Gd(iii)-DOTAREM increases the (13)C polarisation and decreases the (13)C polarisation buildup time of (13)C-urea dissolved in samples containing water/DMSO mixtures with trityl radical (OX063) concentrations of 10 mM or higher. To account for these observations further measurements were carried out at 6.5 K, using a combined EPR and NMR spectrometer. At this temperature, frequency swept DNP spectra of samples with 5 or 10 mM OX063 were measured, with and without 1 mM Gd-DOTA, and again a (13)C enhancement gain was observed due to the presence of Gd-DOTA...
October 28, 2015: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/26382613/non-clinical-safety-assessment-of-gadoterate-meglumine-dotarem-%C3%A2-in-neonatal-and-juvenile-rats
#8
Hervé Giorgi, Jennifer Ammerman, Jean-Paul Briffaux, Nathalie Fretellier, Claire Corot, Philippe Bourrinet
The purpose of this study was to assess the safety of gadoterate meglumine, a gadolinium-based contrast agent used in magnetic resonance imaging, in neonatal and juvenile rats. Rats received a single intravenous administration on postnatal day (PND) 10 or 6 administrations (from PND 10 to 30), at doses of 0, 0.6, 1.25, and 2.5 mmol/kg/administration, i.e. equivalent to approximately 1, 2 and 4-times the usual human dose. The animals were sacrificed at the end of the treatment period or after a 60-day treatment-free period...
December 2015: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/26185325/the-benefits-of-high-relaxivity-for-brain-tumor-imaging-results-of-a-multicenter-intraindividual-crossover-comparison-of-gadobenate-dimeglumine-with-gadoterate-meglumine-the-benefit-study
#9
RANDOMIZED CONTROLLED TRIAL
M Vaneckova, M Herman, M P Smith, M Mechl, K R Maravilla, J Weichet, M V Spampinato, J Žižka, F J Wippold, J J Baima, R Babbel, E Bültmann, R Y Huang, J-H Buhk, A Bonafé, C Colosimo, S Lui, M A Kirchin, N Shen, G Pirovano, A Spinazzi
BACKGROUND AND PURPOSE: Gadobenate dimeglumine (MultiHance) has higher r1 relaxivity than gadoterate meglumine (Dotarem) which may permit the use of lower doses for MR imaging applications. Our aim was to compare 0.1- and 0.05-mmol/kg body weight gadobenate with 0.1-mmol/kg body weight gadoterate for MR imaging assessment of brain tumors. MATERIALS AND METHODS: We performed crossover, intraindividual comparison of 0.1-mmol/kg gadobenate with 0.1-mmol/kg gadoterate (Arm 1) and 0...
September 2015: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/26034414/synthesis-of-gd2o3-eu-nanoplatelets-for-mri-and-fluorescence-imaging
#10
Nabil M Maalej, Ahsanulhaq Qurashi, Achraf Amir Assadi, Ramzi Maalej, Mohammed Nasiruzzaman Shaikh, Muhammad Ilyas, Mohammad A Gondal
We synthesized Gd2O3 and Gd2O3 doped by europium (Eu) (2% to 10%) nanoplatelets using the polyol chemical method. The synthesized nanoplatelets were characterized by X-ray diffraction (XRD), FESEM, TEM, and EDX techniques. The optical properties of the synthesized nanoplatelets were investigated by photoluminescence spectroscopy. We also studied the magnetic resonance imaging (MRI) contrast enhancement of T1 relaxivity using 3 T MRI. The XRD for Gd2O3 revealed a cubic crystalline structure. The XRD of Gd2O3:Eu(3+) nanoplatelets were highly consistent with Gd2O3 indicating the total incorporation of the Eu(3+) ions in the Gd2O3 matrix...
2015: Nanoscale Research Letters
https://www.readbyqxmd.com/read/25867453/the-gadolinium-based-contrast-agent-omniscan%C3%A2-promotes-in-vitro-fibroblast-survival-through-in-situ-precipitation
#11
Min Feng, Yun-Zhou Fan, Xiao-Jie Ma, Jin-Xia Li, Xiao-Gai Yang
The current study aims to explore how the gadolinium (Gd)-based contrast agent (GBCA) Omniscan® enhanced cell viability of murine fibroblasts. The results of scanning electron microscopy showed that Omniscan® can precipitate in cell culture media and deposit on cell membranes. Energy-dispersive X-ray analysis and Fourier-transform infrared spectroscopy demonstrated the presence of Gd and phosphates in the agglomerated particles. By filtering the Omniscan®-containing medium through a 220 nm filter, it can be clearly found that the increased cell viability should be mainly attributed to the insoluble species of gadolinium rather than to chelated gadolinium...
July 2015: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/25325295/a-new-magnetic-resonance-imaging-contrast-agent-loaded-into-poly-lacide-co-glycolide-nanoparticles-for-long-term-detection-of-tumors
#12
G Rigaux, V G Roullin, C Cadiou, C Portefaix, L Van Gulick, G Bœuf, M C Andry, C Hoeffel, L Vander Elst, S Laurent, R Muller, M Molinari, F Chuburu
The incorporation of a lipophilic Gd chelate (GdDO3A-C12) in biocompatible PLGA poly(D, L-lactide-co-glycolide) nanoparticles was explored as an approach to increase the relaxivity of contrast agents for magnetic resonance imaging. By nanoprecipitation, it was possible to obtain PEGylated gadolinium nanoparticles (mean diameter of 155 nm) with high Gd loading (1.1 × 10(4) Gd centers per nanoparticle). The corresponding GdDO3AC12 ⊂ NPs nanoparticles exhibited an enhanced relaxivity (up to sixfold greater than DOTAREM® at 40 MHz) because the nanoparticle framework constrained the lipophilic Gd chelate motion and favorably impacted the Gd chelate rotational correlation time...
November 7, 2014: Nanotechnology
https://www.readbyqxmd.com/read/25290552/multifunctional-rare-earth-vanadate-nanoparticles-luminescent-labels-oxidant-sensors-and-mri-contrast-agents
#13
Mouna Abdesselem, Markus Schoeffel, Isabelle Maurin, Rivo Ramodiharilafy, Gwennhael Autret, Olivier Clément, Pierre-Louis Tharaux, Jean-Pierre Boilot, Thierry Gacoin, Cedric Bouzigues, Antigoni Alexandrou
Collecting information on multiple pathophysiological parameters is essential for understanding complex pathologies, especially given the large interindividual variability. We report here multifunctional nanoparticles which are luminescent probes, oxidant sensors, and contrast agents in magnetic resonance imaging (MRI). Eu(3+) ions in an yttrium vanadate matrix have been demonstrated to emit strong, nonblinking, and stable luminescence. Time- and space-resolved optical oxidant detection is feasible after reversible photoreduction of Eu(3+) to Eu(2+) and reoxidation by oxidants, such as H2O2, leading to a modulation of the luminescence emission...
November 25, 2014: ACS Nano
https://www.readbyqxmd.com/read/25266825/a-new-in-vivo-magnetic-resonance-imaging-method-to-noninvasively-monitor-and-quantify-the-perfusion-capacity-of-three-dimensional-biomaterials-grown-on-the-chorioallantoic-membrane-of-chick-embryos
#14
Fatma Kivrak Pfiffner, Conny Waschkies, Yinghua Tian, Anna Woloszyk, Maurizio Calcagni, Pietro Giovanoli, Markus Rudin, Johanna Buschmann
Adequate vascularization in biomaterials is essential for tissue regeneration and repair. Current models do not allow easy analysis of vascularization of implants in vivo, leaving it a highly desirable goal. A tool that allows monitoring of perfusion capacity of such biomaterials noninvasively in a cheap, efficient, and reliable in vivo model would hence add great benefit to research in this field. We established, for the first time, an in vivo magnetic resonance imaging (MRI) method to quantify the perfusion capacity of a model biomaterial, DegraPol(®) foam scaffold, placed on the embryonic avian chorioallantoic membrane (CAM) in ovo...
April 2015: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/25223524/inter-and-intra-individual-comparative-study-of-two-gadolinium-based-agents-a-pilot-study
#15
RANDOMIZED CONTROLLED TRIAL
Kyung Sook Shin, Mamdoh AlObaidy, Miguel Ramalho, Yong Hwan Jeon, Lauren M Burke, Ersan Altun, Clifton G Stallings, Richard C Semelka
PURPOSE: The aim of the study was to evaluate the acute adverse events rate and enhancement properties of gadoterate meglumine (Dotarem(®)) and gadobenate dimeglumine (MultiHance(®)) in a small-scale controlled double-blinded study, using inter- and intra-individual comparisons. MATERIALS AND METHODS: Forty-one randomly selected patients were scanned with Dotarem(®). The rate of adverse reactions, qualitative and quantitative image evaluation was performed vs...
April 2015: Abdominal Imaging
https://www.readbyqxmd.com/read/24951617/supra-aortic-low-dose-contrast-enhanced-time-resolved-magnetic-resonance-mr-angiography-at-3-t-comparison-with-time-of-flight-mr-angiography-and-high-resolution-contrast-enhanced-mr-angiography
#16
COMPARATIVE STUDY
Youn-Joo Lee, Bum-soo Kim, Ja-Sung Koo, Bom-Yi Kim, Jinhee Jang, Hyun Seok Choi, So-Lyung Jung, Kook-Jin Ahn
BACKGROUND: Low-dose, time-resolved, contrast-enhanced, magnetic resonance angiography (TR-CEMRA) has been described previously; however, a comparative study between low dose TR-CEMRA and time-of-flight MRA (TOF-MRA) in the diagnosis of supra-aortic arterial stenosis has not yet been published. PURPOSE: To demonstrate the feasibility and effectiveness of low-dose TR-CEMRA compared with TOF-MRA, using high-resolution contrast-enhanced MRA (HR-CEMRA) as the reference standard...
June 2015: Acta Radiologica
https://www.readbyqxmd.com/read/24933122/common-carotid-intima-media-thickness-and-ankle-brachial-pressure-index-correlate-with-local-but-not-global-atheroma-burden-a-cross-sectional-study-using-whole-body-magnetic-resonance-angiography
#17
COMPARATIVE STUDY
Jonathan R Weir-McCall, Faisel Khan, Matthew A Lambert, Carly L Adamson, Michael Gardner, Stephen J Gandy, Prasad Guntur Ramkumar, Jill J F Belch, Allan D Struthers, Petra Rauchhaus, Andrew D Morris, J Graeme Houston
BACKGROUND: Common carotid intima media thickness (CIMT) and ankle brachial pressure index (ABPI) are used as surrogate marker of atherosclerosis, and have been shown to correlate with arterial stiffness, however their correlation with global atherosclerotic burden has not been previously assessed. We compare CIMT and ABPI with atheroma burden as measured by whole body magnetic resonance angiography (WB-MRA). METHODS: 50 patients with symptomatic peripheral arterial disease were recruited...
2014: PloS One
https://www.readbyqxmd.com/read/24900422/gd-complexes-of-do3a-biphenyl-2-2-bisamides-conjugates-as-mri-blood-pool-contrast-agents
#18
Ki-Hye Jung, Hee-Kyung Kim, Ji-Ae Park, Ki Soo Nam, Gang Ho Lee, Yongmin Chang, Tae-Jeong Kim
We report the synthesis of DO3A derivatives of 2,2'-diaminobiphenyl (1a,b) and their Gd complexes of the type [Gd(1)(H2O)]·xH2O (2a,b) for use as new MRI blood-pool contrast agents (BPCAs) that provide strong and prolonged vascular enhancement. Pharmacokinetic inertness of 2 compares well with that of structurally related Dotarem, a DOTA-based MRI CA currently in use. The R 1 relaxivity in water reaches 7.3 mM(-1) s(-1), which is approximately twice as high as that of Dotarem (R 1 = 3.9 mM(-1) s(-1)). They show interaction with HSA to give association constants (K a) in the order of two (∼10(2)), revealing the existence of the blood-pool effect...
December 13, 2012: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/24619208/dynamic-contrast-enhanced-magnetic-resonance-imaging-of-breast-tumors-at-3-and-7-t-a-comparison
#19
COMPARATIVE STUDY
Stephan Gruber, Katja Pinker, Olgica Zaric, Lenka Minarikova, Marek Chmelik, Pascal Baltzer, Roland N Boubela, Thomas Helbich, Wolfgang Bogner, Siegfried Trattnig
OBJECTIVES: The objective of this study was to compare the image quality, contrast enhancement behavior, and diagnostic value of bilateral 3-dimensional dynamic contrast-enhanced breast magnetic resonance imaging (MRI), with high spatial and temporal resolution, at 3 and 7 T, in the same patient group. MATERIALS AND METHODS: Twenty-four consecutive patients (mean [SD] age, 57 [17] years) were included in this prospective institutional review board-approved study...
May 2014: Investigative Radiology
https://www.readbyqxmd.com/read/24560458/the-interplay-of-t1-and-t2-relaxation-on-t1-weighted-mri-of-hmscs-induced-by-gd-dota-peptides
#20
Limin Cao, Binbin Li, Peiwei Yi, Hailu Zhang, Jianwu Dai, Bo Tan, Zongwu Deng
Three Gd-DOTA-peptide complexes with different peptide sequence are synthesized and used as T1 contrast agent to label human mesenchymal stem cells (hMSCs) for magnetic resonance imaging study. The peptides include a universal cell penetrating peptide TAT, a linear MSC-specific peptide EM7, and a cyclic MSC-specific peptide CC9. A significant difference in labeling efficacy is observed between the Gd-DOTA-peptides as well as a control Dotarem. All Gd-DOTA-peptides as well as Dotarem induce significant increase in T1 relaxation rate which is in favor of T1-weighted MR imaging...
April 2014: Biomaterials
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