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hepatocellular carcinoma and liver transplantation

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https://www.readbyqxmd.com/read/29341040/risk-factors-for-allograft-failure-in-liver-transplant-recipients
#1
Anna Huesing-Kabar, Christina Zu Dohna, Hauke Heinzow, Vito Rosario Cicinnati, Susanne Beckebaum, Martina Schmidt, Hans Ulrich Gerth, Michele Pohlen, Christian Wilms, Daniel Palmes, Hartmut Hans-Jürgen Schmidt, Iyad Kabar
BACKGROUND:  With regard to quality of life and organ shortage, follow-up after liver transplantation (LT) should consider risk factors for allograft failure in order to avoid the need for re-LT and to improve the long-term outcome of recipients. Therefore, the aim of this study was to explore potential risk factors for allograft failure after LT. MATERIAL AND METHODS:  A total of 489 consecutive LT recipients who received follow-up care at the University Hospital of Muenster were included in this study...
January 16, 2018: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29340553/hepatocellular-carcinoma-diagnosis-and-operative-management
#2
Marcio F Chedid, Cleber R P Kruel, Marcelo A Pinto, Tomaz J M Grezzana-Filho, Ian Leipnitz, Cleber D P Kruel, Leandro A Scaffaro, Aljamir D Chedid
INTRODUCTION: Hepatocellular carcinoma is an aggressive malignant tumor with high lethality. AIM: To review diagnosis and management of hepatocellular carcinoma. METHODS: Literature review using web databases Medline/PubMed. RESULTS: Hepatocellular carcinoma is a common complication of hepatic cirrhosis. Chronic viral hepatitis B and C also constitute as risk factors for its development. In patients with cirrhosis, hepatocelular carcinoma usually rises upon malignant transformation of a dysplastic regenerative nodule...
October 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/29332347/genetically-engineered-bone-marrow-derived-mesenchymal-stem-cells-co-expressing-ifn-%C3%AE-and-il-10-inhibit-hepatocellular-carcinoma-by-modulating-mapk-pathway
#3
Hao Wang, Jun Wang, Xiaolei Shi, Yitao Ding
PURPOSE: One of the major challenges in delivering cytokines for the treatment of hepatocellular carcinoma (HCC) is the mode of delivery. This study hypothesized that genetically engineered bone marrow derived mesenchymal stem cells (BMSCs) co-expressing IFN-γ and IL-10 can serve as a potential therapeutic strategy in the treatment of HCC by inhibiting cell proliferation. METHODS: Male Sprague-Dawley rats (n=5, 200-250 g) for BMSCs isolation and Nude/SCID mice (n=35,12-20g) to develop liver cancer xenograft model were used...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29331341/effects-of-the-gut-liver-axis-on-ischemia-mediated-hepatocellular-carcinoma-recurrence-in-the-mouse-liver
#4
Lorenzo A Orci, Stéphanie Lacotte, Vaihere Delaune, Florence Slits, Graziano Oldani, Vladimir Lazarevic, Carlo Rossetti, Laura Rubbia-Brandt, Philippe Morel, Christian Toso
BACKGROUND & AIMS: There is growing evidence that liver graft ischemia-reperfusion (I/R) is a risk factor for hepatocellular carcinoma (HCC) recurrence, but the involved mechanisms are unclear. Here, we tested the hypothesis that mesenteric congestion due to portal blood flow interruption induces endotoxin-mediated Toll-Like Receptor 4 (Tlr4) engagement, resulting in elevated liver cancer burden. We also assessed the role of remote ischemic preconditioning (RIPC) in this context. METHODS: C57Bl/6j mice were exposed to standardized models of liver I/R injury and RIPC, by occluding hepatic and femoral blood vessels...
January 10, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29327594/liver-resection-and-surgical-strategies-for-management-of-primary-liver-cancer
#5
Sonia T Orcutt, Daniel A Anaya
Primary liver cancer-including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC)-incidence is increasing and is an important source of cancer-related mortality worldwide. Management of these cancers, even when localized, is challenging due to the association with underlying liver disease and the complex anatomy of the liver. Although for ICC, surgical resection provides the only potential cure, for HCC, the risks and benefits of the multiple curative intent options must be considered to individualize treatment based upon tumor factors, baseline liver function, and the functional status of the patient...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29327179/liver-transplantation-is-equally-effective-as-a-salvage-therapy-for-patients-with-hepatocellular-carcinoma-recurrence-following-radiofrequency-ablation-or-liver-resection-with-curative-intent
#6
Hala Muaddi, David P Al-Adra, Rob Beecroft, Anand Ghanekar, Carol-Anne Moulton, Adam Doyle, Markus Selzner, Alice Wei, Ian D McGilvray, Steven Gallinger, David R Grant, Mark S Cattral, Paul D Greig, John Kachura, Sean P Cleary, Gonzalo Sapisochin
BACKGROUND: Liver resection (LR) and radiofrequency ablation (RFA) are curative-intent therapies for early stages of hepatocellular carcinoma (HCC). If HCC recurs, salvage liver transplant (SLT) may constitute a treatment option. OBJECTIVE: We aimed to compare the outcomes of patients transplanted for recurrent HCC after curative-intent therapies with those transplanted as initial therapy. METHODS: We conducted a matched-control (1:1) cohort study comparing patients with HCC treated with primary liver transplant (PLT) with SLT after HCC recurrence...
January 11, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29323061/accuracy-of-vascular-invasion-reporting-in-hepatocellular-carcinoma-before-and-after-implementation-of-subspecialty-surgical-pathology-sign-out
#7
Aaron R Huber, Raul S Gonzalez, Mark S Orloff, Christopher T Barry, Christa L Whitney-Miller
CONTEXT: Liver cancers (including hepatocellular carcinoma [HCC] and cholangiocarcinoma) are the fifth most common cause of cancer death. The most powerful independent histologic predictor of overall survival after transplantation for HCC is the presence of microscopic vascular invasion (VI). AIMS: Given that VI is known to have somewhat high interobserver variability in both HCC and other tumors, we hypothesized that pathologists with special interest and training in liver pathology would be more likely to identify and report VI in HCC than would general surgical pathologists...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29322398/hepatitis-c-virus-infection-and-development-of-type-2-diabetes-mellitus-systematic-review-and-meta-analysis-of-the-literature
#8
REVIEW
Silvia Fabiani, Poupak Fallahi, Silvia Martina Ferrari, Mario Miccoli, Alessandro Antonelli
Type 2 diabetes mellitus (T2DM) is an endocrine disorder encompassing multifactorial mechanisms, and chronic hepatitis C virus infection (CHC) is a multifaceted disorder, associated with extrahepatic manifestations, including endocrinological disorders. CHC and T2DM are associated, but the subject remains controversial. We performed a systematic review and meta-analysis evaluating such association, searching on PubMed until February 29, 2016. Inclusion criteria were: 1) presence of at least one internal control group age- and gender-matched (non-hepatopathic controls; and/or hepatopathic, not HCV-positive, controls); 2) sufficient data to calculate odds ratio and relative risk...
January 11, 2018: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/29319629/patterns-of-discordance-between-pretransplant-imaging-stage-of-hepatocellular-carcinoma-and-posttransplant-pathologic-stage-a-contemporary-appraisal-of-the-milan-criteria
#9
Brett L Ecker, Maarouf A Hoteit, Kimberly A Forde, Christine C Hsu, K Rajender Reddy, Emma E Furth, Evan S Siegelman, Peiman Habibollahi, Edgar Ben-Josef, Paige M Porrett, Peter L Abt, Abraham Shaked, Kim M Olthoff, Matthew H Levine
BACKGROUND: Patients with hepatocellular carcinoma (HCC) exceeding Milan criteria on explant pathology are at increased risk of recurrence and death. Discordance between contemporary magnetic resonance imaging (MRI) and explant pathology, and preoperative characteristics predictive of discordance are not well understood. METHODS: Patients who underwent orthotopic liver transplantation (OLT) for HCC following preoperative MRI were identified in a prospectively collected institutional database (1/2003-12/2013)...
January 10, 2018: Transplantation
https://www.readbyqxmd.com/read/29319620/liver-transplantation-for-nash-related-hepatocellular-carcinoma-versus-non-nash-etiologies-of-hepatocellular-carcinoma
#10
Erin M Sadler, Neil Mehta, Mamatha Bhat, Anand Ghanekar, Paul D Greig, David R Grant, Francis Yao, Gonzalo Sapisochin
BACKGROUND: Liver Transplant (LT) for Non-Alcoholic Steatohepatitis (NASH) related Hepatocellular Carcinoma (HCC) is not well characterized in the literature. The aim of the study was to examine characteristics and outcomes of patients who had LT for NASH-HCC (NASH) vs. HCC from other liver diseases (non-NASH). METHODS: Using a two-centre retrospective design all patients from 2004-2014 that received LT for HCC were analyzed. Subgroup analysis stratified patients according to Milan criteria...
January 10, 2018: Transplantation
https://www.readbyqxmd.com/read/29316067/deep-sequencing-shows-low-level-oncogenic-hepatitis-b-virus-variants-persisting-post-liver-transplant-despite-potent-anti-hbv-prophylaxis
#11
Keith Ck Lau, Carla Osiowy, Elizabeth Giles, Beth Lusina, Guido van Marle, Kelly W Burak, Carla S Coffin
Recent studies suggest that withdrawal of hepatitis B immune globulin (HBIG) and nucleos(t)ide analogues (NA) prophylaxis may be considered in HBV surface antigen (HBsAg) negative liver transplant (LT) recipients with a low risk of disease recurrence. However, the frequency of occult HBV infection (OBI) and HBV variants after LT in the current era of potent NA therapy is unknown. 12 LT recipients on prophylaxis were tested in matched plasma and peripheral blood mononuclear cells (PBMC) for HBV quasispecies by in-house nested PCR and next generation sequencing of amplicons...
January 6, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29315813/liver-transplantation-vs-liver-resection-in-patients-with-hbv-related-hepatocellular-carcinoma-beyond-milan-criterion-a-meta-analysis
#12
REVIEW
Wei Li, Long Li, Jun Han, Hong Wu
OBJECTIVE: The aim of the current study was to conduct a meta-analysis of published reports to compare long-term outcomes after liver transplantation (LT) and liver resection (LR), respectively, in patients with HBV-related hepatocellular carcinoma (HCC) beyond the Milan criterion. METHODS: A systematic search of the Embase, Medline, PubMed databases and the Cochrane Library was performed using both medical subject headings (MeSH) and truncated word searches to identify all comparative studies published on this topic...
January 8, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29312973/critical-appraisal-of-chinese-2017-guideline-on-the-management-of-hepatocellular-carcinoma
#13
REVIEW
Di-Yang Xie, Zheng-Gang Ren, Jian Zhou, Jia Fan, Qiang Gao
Hepatocellular carcinoma (HCC) is the fourth most common and the third most lethal cancer in China. An updated version of consensus-based recommendations on the management of HCC has been recently published by a multidisciplinary group of Chinese experts including liver surgeons, hepatic oncologists, radiologists and pathologists. Major changes have been made to the diagnostic criteria. In addition to dynamic multi-detector computed tomography (CT) and magnetic resonance imaging (MRI), gadoxetic acid-enhanced MRI and contrast-enhanced ultrasound (CEUS) are added to the diagnostic imaging tests...
December 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29311391/cultural-validation-of-the-transplanted-organ-questionnaire-toq-for-the-brazilian-population
#14
Renata Medeiros, Rita Mattiello, Emmanuelle Corruble, Edgar E Sarria, Cibele Molski, Ajacio Brandão
BACKGROUND AND RATIONALE: The Transplanted Organ Questionnaire (TOQ), developed in France, is a disease-targeted instrument designed to evaluate what the transplanted organ represents to the recipient in patients who have undergone liver transplantation. The present study sought to validate a version of the TOQ for use in the Brazilian population. Translation and cross-cultural adaptation were carried out in accordance with international standard practices. Convergent validity was measured by correlations between TOQ domains and the Beck Depression Inventory (BDI), while reliability was assessed by measurement of internal consistency (Cronbach's alpha coefficient), reproducibility (intraclass correlation coefficient), sensitivity to change (effect size), and floor and ceiling effects...
December 27, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29310589/hepatitis-b-reactivation-among-1962-patients-with-hematological-malignancy-in-taiwan
#15
Chien-Yuan Chen, Feng-Ming Tien, Aristine Cheng, Shang-Yi Huang, Wen-Chien Chou, Ming Yao, Jih-Luh Tang, Hwei-Fang Tien, Wang-Huei Sheng
BACKGROUND: The risk of Hepatitis B virus (HBV) reactivation in patients with different hematological malignancy except lymphoma were rarely known before. METHODS: A total of 1962 patients with hematological malignancy were enrolled and followed-up at the National Taiwan University Hospital between 2008 and 2013. The clinical characteristics, HBV serology, and laboratory data were retrospectively reviewed and analyzed. RESULTS: A total of 1962 patients comprising 1048 men and 914 women were studied...
January 8, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29305405/real-world-treatment-of-hepatitis-c-with-second-generation-direct-acting-antivirals-initial-results-from-a-multicentre-canadian-retrospective-cohort-of-diverse-patients
#16
Alex I Aspinall, Abdel A Shaheen, Golasa S Kochaksaraei, Breean Haslam, Samuel S Lee, Gisela Macphail, Jeff Kapler, Oscar E Larios, Kelly W Burak, Mark G Swain, Meredith A Borman, Carla S Coffin
BACKGROUND: High hepatitis C cure rates have been observed in registration trials with second-generation direct-acting antivirals. Real-world data also indicate high sustained viral response (SVR) rates. Our objective was to determine real-world SVR rates for patients infected with hepatitis C virus (HCV) who were treated with second-generation direct-acting antivirals in the first 18 months of their availability in Canada. METHODS: Four centres in Calgary contributed their treatment data for a diverse patient population including those who had or had not undergone liver transplantation, those coinfected with HIV and vulnerable populations...
January 5, 2018: CMAJ Open
https://www.readbyqxmd.com/read/29302641/cancer-immunotherapy-in-patients-with-new-or-recurrent-malignancies-after-liver-transplantation
#17
REVIEW
Mengqi Liu, Wenzhi Guo, Shuijun Zhang
Cancer immunotherapy, as a new treatment modality, has been shown to be effective, especially in metastatic melanoma and lung cancer. Organ transplantation can be a life-saving procedure for patients with end-stage diseases of lung, heart, kidney and liver. While ironically, as improvements in organ transplantation have extended patients' lives, new or recurrent postsurgical malignancies have become an increasing threat to their long-term survival, especially in patients after liver transplantation due to hepatocellular carcinoma...
December 2017: International Journal of Surgery. Oncology
https://www.readbyqxmd.com/read/29299684/treatment-of-hepatitis-c-in-special-populations
#18
REVIEW
Goki Suda, Koji Ogawa, Kenichi Morikawa, Naoya Sakamoto
Hepatitis C virus (HCV) infection is one of the primary causes of liver cirrhosis and hepatocellular carcinoma. In hemodialysis patients, the rate of HCV infection is high and is moreover associated with a poor prognosis. In liver transplantation patients with HCV infection, recurrent HCV infection is universal, and re-infected HCV causes rapid progression of liver fibrosis and graft loss. Additionally, in patients with HCV and human immunodeficiency virus (HIV) co-infection, liver fibrosis progresses rapidly...
January 3, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29299366/bridging-therapy-effectiveness-in-the-treatment-of-hepatocellular-carcinoma-prior-to-orthotopic-liver-transplantation
#19
Maria M Rubinstein, Andreas Kaubisch, Milan Kinkhabwala, John Reinus, Qiang Liu, Jennifer W Chuy
Background: Orthotopic liver transplantation (OLT) is the most effective treatment for hepatocellular carcinoma (HCC) in patients with underlying cirrhosis and portal hypertension. Availability of OLT is limited by donor-organ shortages, which increase patient waiting time until OLT. A variety of bridging therapies (BT) have been used to halt tumor progression in patients on the OLT waiting list. Despite complete radiologic responses following BT, viable tumor is often present in explants...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29291167/epidemic-of-non-alcoholic-fatty-liver-disease-and-hepatocellular-carcinoma
#20
REVIEW
Adnan Said, Aiman Ghufran
Non-alcoholic fatty liver disease (NAFLD) associated hepatocellular carcinoma (HCC) incidence is increasing worldwide, paralleling the obesity epidemic. Although most cases are associated with cirrhosis, HCC can occur without cirrhosis in NAFLD. Diabetes and obesity are associated risk factors for HCC in patients. Given the sheer magnitude of the underlying risk factors (diabetes, obesity, non-cirrhotic NAFLD) screening for HCC in the non-cirrhotic population is not recommended. Optimal screening strategies in NAFLD cirrhosis are not completely elucidated with Ultrasound having significant limitations in detection of liver lesions in the presence of obesity and steatosis...
December 10, 2017: World Journal of Clinical Oncology
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