keyword
https://read.qxmd.com/read/38367116/exploring-the-potential-of-the-carbon-credit-program-for-hedging-energy-prices-in-brazil
#21
JOURNAL ARTICLE
Rafael Baptista Palazzi, Derick David Quintino, Paulo Jorge Silveira Ferreira, Festus Victor Bekun
The transition to a low-carbon economy is imperative to reduce reliance on fossil fuels and mitigate pollution emissions. This preposition also aligns with the United Nations Sustainable Development Goals (SDGs-13), which highlight the climate change action. In this vein, Brazil has implemented the Decarbonization Credit (CBIOS) program to incentivize biofuel production and promote environmental sustainability through carbon credit emissions. To this end, the present study evaluates the effectiveness of the CBIO contract as a hedging tool for investors in the face of energy price fluctuations and decarbonization efforts...
February 17, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38364205/lewis-acid-promoted-oxidative-cleavage-of-carbon-carbon-bonds-synthesis-of-n-arylated-lactam-type-iminosugars
#22
JOURNAL ARTICLE
Yaxin Cui, Likai Zhou, Jilai Wu, Chao Wei, Weiming Wang, Hua Chen
In this paper, a mild strategy for the oxidative cleavage of carbon-carbon bonds catalyzed by Lewis acid was developed in air condition at room temperature. Under such conditions, the bis-carbonyl compounds 3 were directly afforded from the reaction of D-ribose tosylate 1 and aniline in excellent yields through the oxidative cleavage of the key intermediate iminium-ion A and its tautomer enamine B . A series of N -arylated lactam-type iminosugars 5 were then successfully obtained by removing the isopropylidene group from 3 with the aid of the condensation agent DCC...
February 16, 2024: Journal of Organic Chemistry
https://read.qxmd.com/read/38363837/structural-insights-into-the-formation-of-repulsive-netrin-guidance-complexes
#23
JOURNAL ARTICLE
Jessica M Priest, Ev L Nichols, Robert G Smock, Jesse B Hopkins, Juan L Mendoza, Rob Meijers, Kang Shen, Engin Özkan
Netrins dictate attractive and repulsive responses during axon growth and cell migration, where the presence of the receptor Uncoordinated-5 (UNC-5) on target cells results in repulsion. Here, we showed that UNC-5 is a heparin-binding protein, determined its structure bound to a heparin fragment, and could modulate UNC-5-heparin affinity using a directed evolution platform or structure-based rational design. We demonstrated that UNC-5 and UNC-6/netrin form a large, stable, and rigid complex in the presence of heparin, and heparin and UNC-5 exclude the attractive UNC-40/DCC receptor from binding to UNC-6/netrin to a large extent...
February 16, 2024: Science Advances
https://read.qxmd.com/read/38340041/peptide-conjugated-mri-probe-targeted-to-netrin-1-a-novel-metastatic-breast-cancer-biomarker
#24
JOURNAL ARTICLE
Clémentine Moreau, Tea Lukačević, Agnès Pallier, Julien Sobilo, Samia Aci-Sèche, Norbert Garnier, Sandra Même, Éva Tóth, Sara Lacerda
Despite significant progress in cancer imaging and treatment over the years, early diagnosis and metastasis detection remain a challenge. Molecular magnetic resonance imaging (MRI), with its high resolution, can be well adapted to fulfill this need, requiring the design of contrast agents which target specific tumor biomarkers. Netrin-1 is an extracellular protein overexpressed in metastatic breast cancer and implicated in tumor progression and the appearance of metastasis. This study focuses on the design and preclinical evaluation of a novel Netrin-1-specific peptide-based MRI probe, GdDOTA-KKTHDAVR (Gd-K), to visualize metastatic breast cancer...
February 10, 2024: Bioconjugate Chemistry
https://read.qxmd.com/read/38325455/species-profile-of-volatile-organic-compounds-emission-and-health-risk-assessment-from-typical-indoor-events-in-daycare-centers
#25
JOURNAL ARTICLE
Hailin Zheng, Júlia Csemezová, Marcel Loomans, Shalika Walker, Florent Gauvin, Wim Zeiler
Daycare centers (DCCs) play an instrumental role in early childhood development, making them a significant indoor environment for a large number of children globally. Amidst routine DCC activities, young children are exposed to a myriad of volatile organic compounds (VOCs), potentially impacting their health. Therefore, this study aims to investigate the VOC emissions during typical DCCs activities and evaluate respective health risk assessments. Employing a full-scale experimental setup within a well-controlled climate chamber, research was conducted into VOC emissions during three typical DCC events: arts-and-crafts (painting, gluing, modeling), cleaning, and sleeping activities tied to mattresses...
February 5, 2024: Science of the Total Environment
https://read.qxmd.com/read/38317623/development-of-receptor-for-advanced-glycation-end-products-rage-ligands-through-target-directed-dynamic-combinatorial-chemistry-a-novel-class-of-possible-antagonists
#26
JOURNAL ARTICLE
Anca-Elena Dascalu, Christophe Furman, Isabelle Landrieu, François-Xavier Cantrelle, Justine Mortelecque, Gaëlle Grolaux, Philippe Gillery, Frédéric Tessier, Emmanuelle Lipka, Muriel Billamboz, Eric Boulanger, Alina Ghinet
RAGE is a transmembrane receptor of immunoglobulin family that can bind various endogenous and exogenous ligands, initiating the inflammatory downstream signaling pathways, including inflammaging. Therefore, RAGE represents an attractive drug target for age-related diseases. For the development of small-molecule RAGE antagonists, we employed protein-templated dynamic combinatorial chemistry (ptDCC) using RAGE's VC1 domain as a template, the first application of this approach in the context of RAGE. The affinities of DCC hits were validated using microscale thermophoresis...
February 6, 2024: Chemistry: a European Journal
https://read.qxmd.com/read/38316046/epigenetics-in-the-diagnosis-and-prognosis-of-head-and-neck-cancer-a-systematic-review
#27
REVIEW
Isaac Lim, Jade Tan, Anneka Alam, Majdy Idrees, Peter A Brenan, Ricardo Della Coletta, Omar Kujan
BACKGROUND: Aberrant epigenetic modifications significantly develop and progress human malignancies including head and neck squamous cell carcinoma (HNSCC). Taking into account issues of late diagnosis and poor prognosis associated with HNSCC, this systematic review is designed to provide an up-to-date insight of epigenetic changes in the management of HNSCC. METHODS: All studies that assessed the diagnostic and prognostic utilities of epigenetic changes (DNA methylation and histone modifications) among patients diagnosed with HNSCC or oral potentially malignant disorders (OPMDs) were considered for inclusion till June 2023...
February 5, 2024: Journal of Oral Pathology & Medicine
https://read.qxmd.com/read/38314870/defining-the-genetic-landscape-of-congenital-mirror-movements-in-80-affected-individuals
#28
JOURNAL ARTICLE
Meagan L Collins Hutchinson, Judith St-Onge, Sabrina Schlienger, Nassima Boudrahem-Addour, Lina Mougharbel, Jean-Francois Michaud, Clara Lloyd, Elena Bruneau, Cedric Roux, Ahmed N Sahly, Bradley Osterman, Kenneth A Myers, Guy A Rouleau, Daniel Alexander Jimenez Cruz, Jean-Baptiste Rivière, Andrea Accogli, Frederic Charron, Myriam Srour
BACKGROUND: Congenital mirror movements (CMM) is a rare neurodevelopmental disorder characterized by involuntary movements from one side of the body that mirror voluntary movements on the opposite side. To date, five genes have been associated with CMM, namely DCC, RAD51, NTN1, ARHGEF7, and DNAL4. OBJECTIVE: The aim of this study is to characterize the genetic landscape of CMM in a large group of 80 affected individuals. METHODS: We screened 80 individuals with CMM from 43 families for pathogenic variants in CMM genes...
February 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38302905/retrospective-analysis-of-the-prognostic-factors-of-fetal-corpus-callosum-dysplasia
#29
JOURNAL ARTICLE
Ruina Huang, Junya Chen, Xinlin Hou, Lili Liu, Guoyu Sun, Hong Pan, Yinan Ma
BACKGROUND: To analyze the genetic characteristics and long-term outcomes of fetuses with dysplasia of the corpus callosum (DCC) or partial agenesis of the corpus callosum (PACC). METHODS: A total of 42 fetuses with DCC (n = 36) or PACC (n = 6) were retrospectively analyzed from January 2016 to December 2022 at the Peking University First Hospital. The cohort was categorized into isolated (15/42, 36%) and nonisolated groups (27/42, 64%), and differences in the genetic abnormalities and long-term outcomes between the two groups were analyzed...
February 1, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38302194/digital-microscopy-augmented-by-artificial-intelligence-to-interpret-bone-marrow-samples-for-hematological-diseases
#30
JOURNAL ARTICLE
David Bermejo-Peláez, Sandra Rueda Charro, María García Roa, Roberto Trelles-Martínez, Alejandro Bobes-Fernández, Marta Hidalgo Soto, Roberto García-Vicente, María Luz Morales, Alba Rodríguez-García, Alejandra Ortiz-Ruiz, Alberto Blanco Sánchez, Adriana Mousa Urbina, Elisa Álamo, Lin Lin, Elena Dacal, Daniel Cuadrado, María Postigo, Alexander Vladimirov, Jaime Garcia-Villena, Andrés Santos, María Jesús Ledesma-Carbayo, Rosa Ayala, Joaquín Martínez-López, María Linares, Miguel Luengo-Oroz
Analysis of bone marrow aspirates (BMAs) is an essential step in the diagnosis of hematological disorders. This analysis is usually performed based on a visual examination of samples under a conventional optical microscope, which involves a labor-intensive process, limited by clinical experience and subject to high observer variability. In this work, we present a comprehensive digital microscopy system that enables BMA analysis for cell type counting and differentiation in an efficient and objective manner...
February 1, 2024: Microscopy and Microanalysis
https://read.qxmd.com/read/38301364/solitary-fibrous-tumor-can-the-new-huang-risk-stratification-system-for-orbital-tumors-improve-prognostic-accuracy-in-other-tumor-locations
#31
JOURNAL ARTICLE
Emilio Medina-Ceballos, Isidro Machado, Francisco Giner, Álvaro Blázquez Bujeda, Samuel Navarro, Antonio Ferrandez, Javier Lavernia, Amparo Ruíz-Sauri, Antonio Llombart-Bosch
Solitary fibrous tumors (SFTs) are known for their heterogeneous morphology, characterized by a variety of cell shapes and different growth patterns. They can also arise in various anatomical locations, most commonly in extremities and deep soft tissues. Despite this diversity in morphology and location, all SFTs share a common molecular signature involving the NAB2::STAT6 gene fusion. Due to their unpredictable clinical behavior, establishing prognostic factors is crucial. This study aims to evaluate an orbital risk stratification system (RSS) proposed by Huang et al...
January 19, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38300327/new-candidate-region-for-mirror-hand-movements-two-patients-with-terminal-9p-deletion-and-20p-duplication
#32
JOURNAL ARTICLE
Pelin Ozyavuz Cubuk
The 9p deletion syndrome, which was defined in a detailed way in the previous studies, was characterized by various clinical features such as psychomotor retardation, dysmorphic features and genital anomalies. In contrast to 9p deletion syndrome, 20p duplication was rarely reported in the literature with only a few case reports. Regarding the combination of 9p deletion syndrome and 20p duplication, we found that it was reported in only four patients. In the current study, we aimed to investigate a rare chromosomal rearrangement, partial monosomy 9p and trisomy 20p which was observed in two patients with mirror hand movements...
February 1, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38290101/staff-perspectives-on-dementia-care-in-nursing-homes-a-pre-implementation-content-analysis-study-guided-by-the-practical-robust-implementation-and-sustainability-model
#33
JOURNAL ARTICLE
Natalie F Douglas, Abigail Snell, Joan G Carpenter
PURPOSE: To assess implementation context prior to the implementation of Dementia Collaborative Coaching (DCC), a person-centered, communication coaching intervention for speech-language pathologists, certified nursing assistants, and people living with dementia in nursing homes. METHODS: This was a pre-implementation, content analysis of focus groups. Focus group questions and subsequent analysis were guided by the Practical, Robust Implementation and Sustainability Model...
February 2024: Journal of Gerontological Nursing
https://read.qxmd.com/read/38289151/-the-sulfur-dance-around-arenes-and-heteroarenes-the-reversible-nature-of-nucleophilic-aromatic-substitutions
#34
JOURNAL ARTICLE
Sapna Gahlot, Jean-Louis Schmitt, Aline Chevalier, Marco Villa, Myriam Roy, Paola Ceroni, Jean-Marie Lehn, Marc Gingras
We disclose the features of a category of reversible nucleophilic aromatic substitutions in view of their significance and generality in dynamic aromatic chemistry. Exchange of sulfur components surrounding arenes and heteroarenes may occur at 25°C, in a process that one may call a "sulfur dance". These SNAr systems present their own features, apart from common reversible reactions utilized in dynamic chemistry (DCC). By varying conditions, covalent dynamics may operate to provide libraries of thiaarenes with some selectivity, or conversion of a hexa(thio)benzene asterisk into another one...
January 30, 2024: Chemistry: a European Journal
https://read.qxmd.com/read/38289148/possible-role-of-netrin-1-deleted-in-colorectal-cancer-vascular-endothelial-growth-factor-signaling-pathway-in-the-pathogenesis-of-placenta-accreta-spectrum-a-case-control-study
#35
JOURNAL ARTICLE
Dalia M Badary, Huda Elsaied, Mahmoud R Abdel-Fadeil, Mohammed K Ali, Hisham Abou-Taleb, Heba M Iraqy
Netrin-1, an epithelial-secreted protein, plays a key role in placental formation through the promotion of cytotrophoblast proliferation and placental vascular development. These effects are mediated through several receptors, including the deleted in colorectal cancer (DCC) receptor. Placenta accreta spectrum (PAS) is an exaggerated trophoblastic invasion into the uterine myometrium. The exact etiology is unknown, but it is believed that increased trophoblastic invasion, defect decidualization, and/or abnormal angiogenesis might play a role...
January 29, 2024: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38287090/pathogenic-likely-pathogenic-mutations-identified-in-vietnamese-children-diagnosed-with-autism-spectrum-disorder-using-high-resolution-snp-genotyping-platform
#36
JOURNAL ARTICLE
Duyen T Bui, Anh N V Ton, Chi T D Nguyen, Son H Nguyen, Hao K Tran, Xuan T Nguyen, Hang T Nguyen, Giang L T Pham, Dong S Tran, Jillian Harrington, Hiep N Pham, Tuyen N V Pham, Tuan A Cao
Among the most prevalent neurodevelopmental disorders, Autism Spectrum Disorder (ASD) is highly diverse showing a broad phenotypic spectrum. ASD also couples with a broad range of mutations, both de novo and inherited. In this study, we used a proprietary SNP genotyping chip to analyze the genomic DNA of 250 Vietnamese children diagnosed with ASD. Our Single Nucleotide Polymorphism (SNP) genotyping chip directly targets more than 800 thousand SNPs in the genome. Our primary focus was to identify pathogenic/likely pathogenic mutations that are potentially linked to more severe symptoms of autism...
January 29, 2024: Scientific Reports
https://read.qxmd.com/read/38287060/construction-and-optimization-of-representative-actual-driving-cycles-based-on-the-improved-autoencoder
#37
JOURNAL ARTICLE
Zhichao Zhao, Xilei Sun, Xun Wang, Yi Wang, Jianqin Fu, Jingping Liu
In this study, much work has been performed to accurately and efficiently develop representative actual driving cycles. Electric vehicle road tests were conducted and the associated data were gathered based on the manual driving method, and the Changsha Driving Cycle Construction (CS-DCC) method was proposed to achieve systematical construction of a representative driving cycle from the original data. The results show that the refined data exhibit greater stability and a smoother pattern in contrast to the original data after noise reduction by five-scale wavelet analysis...
January 29, 2024: Scientific Reports
https://read.qxmd.com/read/38271459/risk-and-causality-co-movement-of-malaysia-s-stock-market-with-its-emerging-and-oecd-trading-partners-evidence-from-the-wavelet-approach
#38
JOURNAL ARTICLE
Xiaoyang Wang, Hui Guo, Muhammad Waris, Badariah Haji Din
The growing trend of interdependence between the international stock markets indicated the amalgamation of risk across borders that plays a significant role in portfolio diversification by selecting different assets from the financial markets and is also helpful for making extensive economic policy for the economies. By applying different methodologies, this study undertakes the volatility analysis of the emerging and OECD economies and analyzes the co-movement pattern between them. Moreover, with that motive, using the wavelet approach, we provide strong evidence of the short and long-run risk transfer over different time domains from Malaysia to its trading partners...
2024: PloS One
https://read.qxmd.com/read/38271317/thank-you-dccn-2023-peer-reviewers
#39
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 2024: Dimensions of Critical Care Nursing: DCCN
https://read.qxmd.com/read/38271316/book-and-media-review
#40
JOURNAL ARTICLE
Kathleen Ahern Gould
No abstract text is available yet for this article.
March 2024: Dimensions of Critical Care Nursing: DCCN
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