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https://www.readbyqxmd.com/read/29161591/cell-invasion-in%C3%A2-vivo-via-rapid-exocytosis-of-a-transient-lysosome-derived-membrane-domain
#1
Kaleb M Naegeli, Eric Hastie, Aastha Garde, Zheng Wang, Daniel P Keeley, Kacy L Gordon, Ariel M Pani, Laura C Kelley, Meghan A Morrissey, Qiuyi Chi, Bob Goldstein, David R Sherwood
Invasive cells use small invadopodia to breach basement membrane (BM), a dense matrix that encases tissues. Following the breach, a large protrusion forms to clear a path for tissue entry by poorly understood mechanisms. Using RNAi screening for defects in Caenorhabditis elegans anchor cell (AC) invasion, we found that UNC-6(netrin)/UNC-40(DCC) signaling at the BM breach site directs exocytosis of lysosomes using the exocyst and SNARE SNAP-29 to form a large protrusion that invades vulval tissue. Live-cell imaging revealed that the protrusion is enriched in the matrix metalloprotease ZMP-1 and transiently expands AC volume by more than 20%, displacing surrounding BM and vulval epithelium...
November 20, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29154364/non-contingent-exposure-to-amphetamine-in-adolescence-recruits-mir-218-to-regulate-dcc-expression-in-the-vta
#2
Santiago Cuesta, José Maria Restrepo-Lozano, Steven Silvestrin, Dominique Nouel, Angélica Torres-Berrio, Lauren M Reynolds, Andreas Arvanitogiannis, Cecilia Flores
The development of the dopamine input to the medial prefrontal cortex occurs during adolescence and is a process that is vulnerable to disruption by stimulant drugs such as amphetamine. We have previously linked the amphetamine-induced disruption of dopamine connectivity and prefrontal cortex maturation during adolescence to the downregulation of the Netrin-1 receptor, DCC, in dopamine neurons. However, how DCC expression in dopamine neurons is itself regulated is completely unknown. MicroRNA (miRNA) regulation of mRNA translation and stability is a prominent mechanism linking environmental events to changes in protein expression...
November 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29152971/a-cascade-dehydrogenative-cross-coupling-annulation-reaction-of-benzamides-with-%C3%AE-keto-esters-for-the-synthesis-of-isoquinolinone-derivatives
#3
Guo-Dong Xu, Zhi-Zhen Huang
A novel cascade DCC/annulation reaction of N-alkoxybenzamides with β-keto esters has been developed for the synthesis of isoquinolinone derivatives under palladium catalysis. A plausible mechanism involving α-C(sp(2))-H activation and a Pd(II)/Pd(IV) catalytic cycle is also proposed.
November 20, 2017: Organic Letters
https://www.readbyqxmd.com/read/29141180/motor-neuron-migration-and-positioning-mechanisms-new-roles-for-guidance-cues
#4
REVIEW
Minkyung Kim, Brielle Bjorke, Grant S Mastick
Motor neurons differentiate from progenitor cells and cluster as motor nuclei, settling next to the floor plate in the brain stem and spinal cord. Although precise positioning of motor neurons is critical for their functional input and output, the molecular mechanisms that guide motor neurons to their proper positions remain poorly understood. Here, we review recent evidence of motor neuron positioning mechanisms, highlighting situations in which motor neuron cell bodies can migrate, and experiments that show that their migration is regulated by axon guidance cues...
November 12, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29136250/genetic-overlap-between-schizophrenia-and-volumes-of-hippocampus-putamen-and-intracranial-volume-indicates-shared-molecular-genetic-mechanisms
#5
Olav B Smeland, Yunpeng Wang, Oleksandr Frei, Wen Li, Derrek P Hibar, Barbara Franke, Francesco Bettella, Aree Witoelar, Srdjan Djurovic, Chi-Hua Chen, Paul M Thompson, Anders M Dale, Ole A Andreassen
Schizophrenia (SCZ) is associated with differences in subcortical brain volumes and intracranial volume (ICV). However, little is known about the underlying etiology of these brain alterations. Here, we explored whether brain structure volumes and SCZ share genetic risk factors. Using conditional false discovery rate (FDR) analysis, we integrated genome-wide association study (GWAS) data on SCZ (n = 82315) and GWAS data on 7 subcortical brain volumes and ICV (n = 11840). By conditioning the FDR on overlapping associations, this statistical approach increases power to discover genetic loci...
November 9, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29121952/association-between-oxidative-stress-and-cord-serum-lipids-in-relation-to-delayed-cord-clamping-in-term-neonates
#6
Asmaa N Moustafa, Mahmoud H Ibrahim, Suzan Omar Mousa, Ebtesam E Hassan, Hashem F Mohamed, Hend M Moness
BACKGROUND: Although delayed cord clamping (DCC) is a recent WHO recommendation, early cord clamping (ECC) is still a routine practice in many countries. Limited researches studied the effect of delayed cord clamping on oxidative stress in term neonates; In this study we aim to assess the influence of cord clamping either early or late on oxidative stress in term neonates and to evaluate the association of oxidative stress and cord blood lipids. METHODS: One-hundred mothers and their term neonates were included in the present study...
November 9, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29111071/biocompatible-chitosan-based-hydrogels-for-potential-application-in-local-tumour-therapy
#7
Anda-Mihaela Olaru, Luminita Marin, Simona Morariu, Gabriela Pricope, Mariana Pinteala, Liliana Tartau-Mititelu
A series of hydrogels based on chitosan polyamine and nitrosalicylaldehyde were prepared via dynamic covalent chemistry (DCC), by imination and transimination reactions towards ordered clusters which play the role of crosslinking nodes of the chitosan network. The hydrogelation mechanism has been proved through NMR and FTIR spectroscopy, X-ray diffraction and polarized light microscopy. The successful preparation of the hydrogels and their mechanical properties were further investigated using rheological measurements...
January 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29101631/effect-of-placental-transfusion-on-iron-stores-in-moderately-preterm-neonates-of-30-33%C3%A2-weeks-gestation
#8
Bikramjit Das, Venkataseshan Sundaram, Praveen Kumar, William T Mordi, Lakhbir K Dhaliwal, Reena Das
OBJECTIVE: To assess the effect of placental transfusion by delayed cord clamping (DCC) of 60 s or cord milking (CM) on serum ferritin levels at hospital discharge and 3 mo of postmenstrual age (PMA) in preterm neonates of 30 to 33 wk gestation in comparison to early cord clamping (ECC) within 10 s. METHODS: This mixed longitudinal study was conducted in moderately preterm neonates of 30 to 33 wk gestation born in a level III unit in Northern India with the study sample nested within a randomized controlled trial on placental transfusion...
November 4, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29092889/a-statistically-oriented-asymmetric-localization-soal-model-for-neuronal-outgrowth-patterning-by-caenorhabditis-elegans-unc-5-unc5-and-unc-40-dcc-netrin-receptors
#9
Gerard Limerick, Xia Tang, Won Suk Lee, Ahmed Mohamed, Aseel Al-Aamiri, William G Wadsworth
Neurons extend processes that vary in number, length, and direction of outgrowth. Extracellular cues help determine outgrowth patterns. In Caenorhabditis elegans, neurons respond to the extracellular UNC-6 (netrin) cue via UNC-40 (DCC) and UNC-5 (UNC5) receptors. Previously we presented evidence that UNC-40 asymmetric localization at the plasma membrane is self-organizing and that UNC-40 can localize and mediate outgrowth at randomly selected sites. Here we provide further evidence for a statistically oriented asymmetric localization (SOAL) model in which UNC-5 receptor activity affects patterns of axon outgrowth by regulating UNC-40 asymmetric localization...
November 1, 2017: Genetics
https://www.readbyqxmd.com/read/29089385/structural-features-of-the-tatc-membrane-protein-that-determine-docking-and-insertion-of-a-twin-arginine-signal-peptide
#10
Anne-Sophie Blümmel, Friedel Drepper, Bettina Knapp, Ekaterina Eimer, Bettina Warscheid, Matthias Müller, Julia Fröbel
Twin-arginine translocation (Tat) systems transport folded proteins across cellular membranes with the concerted action of mostly three membrane proteins: TatA, TatB, and TatC. Hetero-oligomers of TatB and TatC form circular substrate-receptor complexes with a central binding cavity for twin arginine-containing signal peptides. After binding of the substrate, energy from an electro-chemical proton gradient is transduced into the recruitment of TatA oligomers and into the actual translocation event. We previously reported, that Tat-dependent protein translocation into membrane vesicles of Escherichia coli is blocked by the compound N,N'-dicyclohexylcarbodiimide (DCCD, DCC)...
October 31, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29068161/dcc-mutation-update-congenital-mirror-movements-isolated-agenesis-of-the-corpus-callosum-and-developmental-split-brain-syndrome
#11
Ashley Pl Marsh, Timothy J Edwards, Charles Galea, Helen M Cooper, Elizabeth C Engle, Saumya S Jamuar, Aurélie Méneret, Marie-Laure Moutard, Caroline Nava, Agnès Rastetter, Gail Robinson, Guy Rouleau, Emmanuel Roze, Megan Spencer-Smith, Oriane Trouillard, Thierry Billette de Villemeur, Christopher A Walsh, Timothy W Yu, Delphine Heron, Elliott H Sherr, Linda J Richards, Christel Depienne, Richard J Leventer, Paul J Lockhart
The deleted in colorectal cancer (DCC) gene encodes the netrin-1 receptor DCC, a transmembrane protein required for the guidance of commissural axons. Germline DCC mutations disrupt the development of predominantly commissural tracts in the central nervous system (CNS) and cause a spectrum of neurological disorders. Monoallelic, missense and predicted loss-of-function DCC mutations cause congenital mirror movements, isolated agenesis of the corpus callosum, or both. Biallelic, predicted loss-of-function DCC mutations cause developmental split brain syndrome...
October 25, 2017: Human Mutation
https://www.readbyqxmd.com/read/29060604/dynamical-brain-connectivity-estimation-using-garch-models-an-application-to-personality-neuroscience
#12
R Riccelli, L Passamonti, A Duggento, M Guerrisi, I Indovina, A Terracciano, N Toschi
It has recently become evident that the functional connectome of the human brain is a dynamical entity whose time evolution carries important information underpinning physiological brain function as well as its disease-related aberrations. While simple sliding window approaches have had some success in estimating dynamical brain connectivity in a functional MRI (fMRI) context, these methods suffer from limitations related to the arbitrary choice of window length and limited time resolution. Recently, Generalized autoregressive conditional heteroscedastic (GARCH) models have been employed to generate dynamical covariance models which can be applied to fMRI...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059224/netrin-1-is-a-novel-regulator-of-vascular-endothelial-function-in-diabetes
#13
Haroldo A Toque, Aracely Fernandez-Flores, Riyaz Mohamed, Ruth B Caldwell, Ganesan Ramesh, R William Caldwell
BACKGROUND: Netrin-1, a secreted laminin-like protein identified as an axon guidance molecule, has been shown to be of critical importance in the cardiovascular system. Recent studies have revealed pro-angiogenic, anti-apoptotic and anti-inflammatory properties of netrin-1 as well as cardioprotective actions against myocardial injury in diabetic mice. AIM: To examine the role of netrin-1 in diabetes-and high glucose (HG)-induced vascular endothelial dysfunction (VED) using netrin-1 transgenic mice (Tg3) and cultured bovine aortic endothelial cells (BAEC)...
2017: PloS One
https://www.readbyqxmd.com/read/29044505/diagnostic-pathology-of-early-systemic-cancer-erbb2-gene-amplification-in-single-disseminated-cancer-cells-determines-patient-survival-in-operable-esophageal-cancer
#14
Martin Hoffmann, Sophie Pasch, Thomas Schamberger, Matthias Maneck, Birte Möhlendick, Sarah Schumacher, Gero Brockhoff, Wolfram Trudo Knoefel, Jakob Izbicki, Bernhard Polzer, Nikolas H Stoecklein, Christoph A Klein
Early metastatic dissemination and evolution of disseminated cancer cells (DCCs) outside the primary tumor is one reason for the failure of adjuvant therapies because it generates molecular geno- and phenotypes different from primary tumors which still underlie therapy decisions. Since ERBB2 amplification in esophageal DCCs but not in primary tumor cells predict outcome, we aimed to establish an assay with diagnostic reliability for single DCCs or circulating tumor cells (CTCs). For this we evaluated copy number alterations of more than 600 single DCCs from multiple cancer types to define reference regions suitable for quantification of target regions, such as ERBB2...
October 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29041904/shift-in-the-function-of-netrin-1-from-axon-outgrowth-to-axon-branching-in-developing-cerebral-cortical-neurons
#15
Hideko Matsumoto, Masabumi Nagashima
BACKGROUND: Netrin-1, a multifunctional axon guidance cue, elicits axon outgrowth via one of its receptors deleted in colorectal cancer (DCC) in several types of neurons, including cerebral cortical neurons of embryonic mice. However, we and others have observed de novo formation of axon branches without axon outgrowth induced by netrin-1 in cortical culture of neonatal hamsters. These previous reports suggested the possibility that netrin-1 function might alter during development, which we here investigated using dissociated culture prepared from cerebral cortices of embryonic mice...
October 17, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/29037439/caenorhabditis-elegans-dosage-compensation-insights-into-condensin-mediated-gene-regulation
#16
REVIEW
Sarah Elizabeth Albritton, Sevinç Ercan
Recent work demonstrating the role of chromosome organization in transcriptional regulation has sparked substantial interest in the molecular mechanisms that control chromosome structure. Condensin, an evolutionarily conserved multisubunit protein complex, is essential for chromosome condensation during cell division and functions in regulating gene expression during interphase. In Caenorhabditis elegans, a specialized condensin forms the core of the dosage compensation complex (DCC), which specifically binds to and represses transcription from the hermaphrodite X chromosomes...
October 13, 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/29032842/making-dopamine-connections-in-adolescence
#17
REVIEW
Daniel Hoops, Cecilia Flores
A dramatic maturational process ongoing in adolescence is prefrontal cortex development, including its dopamine innervation. Dopamine axons grow from the striatum to the prefrontal cortex, the only known case of long-distance axon growth during adolescence. This is coordinated by the Netrin-1 guidance cue receptor DCC (deleted in colorectal cancer), which in turn controls the intrinsic development of the prefrontal cortex itself. Stimulant drugs in adolescence alter DCC in dopamine neurons and, in turn prefrontal cortex maturation, impacting cognitive abilities...
October 9, 2017: Trends in Neurosciences
https://www.readbyqxmd.com/read/29023534/bewith-a-between-within-method-to-discover-relationships-between-cancer-modules-via-integrated-analysis-of-mutual-exclusivity-co-occurrence-and-functional-interactions
#18
Phuong Dao, Yoo-Ah Kim, Damian Wojtowicz, Sanna Madan, Roded Sharan, Teresa M Przytycka
The analysis of the mutational landscape of cancer, including mutual exclusivity and co-occurrence of mutations, has been instrumental in studying the disease. We hypothesized that exploring the interplay between co-occurrence, mutual exclusivity, and functional interactions between genes will further improve our understanding of the disease and help to uncover new relations between cancer driving genes and pathways. To this end, we designed a general framework, BeWith, for identifying modules with different combinations of mutation and interaction patterns...
October 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29017609/effects-of-intra-arterial-transplantation-of-adipose-derived-stem-cells-on-the-expression-of-netrin-1-and-its-receptor-dcc-in-the-peri-infarct-cortex-after-experimental-stroke
#19
Huan Huang, Fan Lin, Jingjing Jiang, Yan Chen, Ainong Mei, Pengli Zhu
BACKGROUND: Stem cell transplantation has been documented to promote functional recovery in animal models of stroke; however, the underlying mechanisms are not yet fully understood. As netrin-1 and its receptor deleted in colorectal cancer (DCC) are important regulators in neuronal and vascular activities, the present study attempted to explore whether netrin-1 and DCC are involved in the neuroprotection of stem cell-based therapies in a rat ischemic stroke model. METHODS: Adult male Sprague-Dawley rats were subjected to a transient middle cerebral artery occlusion (MCAO) and subsequently received an intra-arterial injection of 2 × 10(6) PKH26-labeled adipose-derived stem cells (ADSCs) or saline 24 h later...
October 10, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28986144/motor-axons-are-guided-to-exit-points-in-the-spinal-cord-by-slit-and-netrin-signals
#20
Minkyung Kim, Tatiana M Fontelonga, Clare H Lee, Sarah J Barnum, Grant S Mastick
In the spinal cord, motor axons project out the neural tube at specific exit points, then bundle together to project toward target muscles. The molecular signals that guide motor axons to and out of their exit points remain undefined. Since motor axons and their exit points are located near the floor plate, guidance signals produced by the floor plate and adjacent ventral tissues could influence motor axons as they project toward and out of exit points. The secreted Slit proteins are major floor plate repellents, and motor neurons express two Slit receptors, Robo1 and Robo2...
December 1, 2017: Developmental Biology
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