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https://www.readbyqxmd.com/read/29343638/commissural-neurons-transgress-the-cns-pns-boundary-in-absence-of-ventricular-zone-derived-netrin-1
#1
Juan Antonio Moreno-Bravo, Sergi Roig Puiggros, Heike Blockus, Chloé Dominici, Pavol Zelina, Patrick Mehlen, Alain Chédotal
During the development of the central nervous system (CNS), only motor axons project into peripheral nerves. Little is known about the cellular and molecular mechanisms that control the development of a boundary at the CNS surface and prevent CNS neuron emigration from the neural tube. It has previously been shown that a subset of spinal cord commissural axons abnormally invades sensory nerves in Ntn1 hypomorphic embryos and Dcc knockouts. However, whether netrin 1 also plays a similar role in the brain is unknown...
January 17, 2018: Development
https://www.readbyqxmd.com/read/29339781/draxin-regulates-hippocampal-neurogenesis-in-the-postnatal-dentate-gyrus-by-inhibiting-dcc-induced-apoptosis
#2
Hiroshi Tawarayama, Hirohisa Yamada, Ruhul Amin, Yuiko Morita-Fujimura, Helen M Cooper, Yohei Shinmyo, Masakado Kawata, Shuntaro Ikawa, Hideaki Tanaka
Hippocampal neurogenesis in the dentate gyrus (DG) is controlled by diffusible molecules that modulate neurogenic processes, including cell proliferation, differentiation and survival. To elucidate the mechanisms underlying hippocampal neurogenesis, we investigated the function of draxin, originally identified as a neural chemorepellent, in the regulation of neuronal survival in the DG. Draxin was expressed in Tbr2 (+) late progenitors and NeuroD1 (+) neuroblasts in the dentate granule cell lineage, whereas expression of its receptor DCC (deleted in colorectal cancer) was mainly detectable in neuroblasts...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29324923/the-operation-of-the-day-care-centre-of-alzheimer-hellas-saint-helen-and-of-the-memory-clinic-of-papanikolaou-general-hospital-from-2007-to-2017
#3
Chrysa Papasozomenou, Eleni Poptsi, Eirini Maria Tabaki, Magda Tsolaki
OBJECTIVE: Nowadays, there is a rapid increase of neurocognitive disorders (ND), while Alzheimer disease (AD), is the most frequent type of neurodegeneration. Therefore, Day Care Centers (DCC) and Memory Clinics (MC) have been created in order to correspond to the rising needs of people with ND. The aim of the study was to record clinical and demographic characteristics of people with ND from the broader area of Thessaloniki. SUBJECTS AND METHODS: Data bases were collected and were analyzed in order to examine demographical characteristics of all visitors of the DCC of Alzheimer Hellas and of visitors of the Papanikolaou General Hospital, during the years 2007-2017...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29323897/a-series-of-weakley-type-polyoxomolybdates-synthesis-characterization-and-magnetic-properties-by-a-combined-experimental-and-theoretical-approach
#4
Shan She, Chen Gao, Kun Chen, Aruuhan Bayaguud, Yichao Huang, Bing-Wu Wang, Song Gao, Yongge Wei
Using DCC as the dehydrating agent, a series of Weakley-type polyoxomolybdates [Bu4N]3{Ln[Mo5O13(OMe)4(NO)]2} (Ln = Tb, Dy, Ho, Er) were synthesized in a one-pot reaction and structurally characterized by elemental, IR, UV-vis analysis, PXRD, and single-crystal X-ray diffraction. Furthermore, the static and dynamic measurements were utilized to investigate their magnetic performances. Typically, slow relaxation of magnetization was observed for Dy analogues with an energy barrier for the reversal of the magnetization of 50 K, which is the highest barrier height observed on the polyoxomolybdates-based single-molecule magnets (SMMs)...
January 11, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29323791/imine-based-architectures-at-surfaces-and-interfaces-from-self-assembly-to-dynamic-covalent-chemistry-in-2d
#5
Iwona Janica, Violetta Patroniak, Paolo Samorì, Artur Ciesielski
During the last two decades dynamic covalent chemistry (DCC) has emerged as an efficient and versatile strategy for the design and synthesis of complex molecular systems in solution. While early examples of supramolecularly assisted covalent synthesis at surfaces relied strongly on kinetically controlled reactions for post-assembly covalent modification, the DCC method takes advantage of the reversible nature of bond formation and allows the generation of the new covalently bonded structures under thermodynamic control...
January 11, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29323275/rna-damid-reveals-cell-type-specific-binding-of-rox-rnas-at-chromatin-entry-sites
#6
Seth W Cheetham, Andrea H Brand
Thousands of long noncoding RNAs (lncRNAs) have been identified in eukaryotic genomes, many of which are expressed in spatially and temporally restricted patterns. Nonetheless, the roles of the majority of these transcripts are still unknown. One of the mechanisms by which lncRNAs function is through the modulation of chromatin states. To assess the functions of lncRNAs, we developed RNA-DamID, a novel approach that detects lncRNA-genome interactions in a cell-type-specific manner in vivo with high sensitivity and accuracy...
January 2018: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/29284660/the-modern-resource-genome-wide-binding-profiles-for-hundreds-of-drosophila-and-caenorhabditis-elegans-transcription-factors
#7
Michelle M Kudron, Alec Victorsen, Louis Gevirtzman, LaDeana W Hillier, William W Fisher, Dionne Vafeados, Matt Kirkey, Ann S Hammonds, Jeffery Gersch, Haneen Ammouri, Martha L Wall, Jennifer Moran, David Steffen, Matt Szynkarek, Samantha Seabrook-Sturgis, Nader Jameel, Madhura Kadaba, Jaeda Patton, Robert Terrell, Mitch Corson, Timothy J Durham, Soo Park, Swapna Samanta, Mei Han, Jinrui Xu, Koon-Kiu Yan, Susan E Celniker, Kevin P White, Lijia Ma, Mark Gerstein, Valerie Reinke, Robert Waterston
In order to develop a catalog of regulatory sites in two major model organisms, Drosophilia melanogaster and Caenorhabditis elegans, the modERN consortium has systematically assayed the binding sites of transcription factors (TFs). Combined with data produced by our predecessor, modENCODE, we now have data for 262 TFs identifying 1.23M sites in the fly genome and 217 TFs identifying 0.67M sites in the worm genome. Because sites from different TFs are often overlapping and tightly clustered, they fall into 91,011 and 59,150 regions in the fly and worm, respectively, and these binding sites span as little as 8...
December 28, 2017: Genetics
https://www.readbyqxmd.com/read/29273812/diurnal-cloud-cycle-biases-in-climate-models
#8
Jun Yin, Amilcare Porporato
Clouds' efficiency at reflecting solar radiation and trapping the terrestrial radiation is strongly modulated by the diurnal cycle of clouds (DCC). Much attention has been paid to mean cloud properties due to their critical role in climate projections; however, less research has been devoted to the DCC. Here we quantify the mean, amplitude, and phase of the DCC in climate models and compare them with satellite observations and reanalysis data. While the mean appears to be reliable, the amplitude and phase of the DCC show marked inconsistencies, inducing overestimation of radiation in most climate models...
December 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/29260427/efficacy-and-safety-of-dabigatran-in-patients-with-atrial-fibrillation-scheduled-for-transoesophageal-echocardiogram-guided-direct-electrical-current-cardioversion-a-prospective-propensity-score-matched-cohort-study
#9
Vincenzo Russo, Anna Rago, Andrea Antonio Papa, Antonio D'Onofrio, Paolo Golino, Gerardo Nigro
Patients with atrial fibrillation (AF) are predisposed to a hypercoagulable state and are at an increased risk for thromboembolic events when undergoing procedures. This study investigated the long-term efficacy and safety of newly initiated anticoagulation with dabigatran versus uninterrupted vitamin K antagonist (VKA) therapy in patients with AF scheduled for transesophageal echocardiogram (TEE)-guided direct electrical current cardioversion (DCC). Consecutive adult patients with persistent AF scheduled to undergo DCC were included in the study...
December 19, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29246467/a-randomized-clinical-trial-of-umbilical-cord-milking-vs-delayed-cord-clamping-in-preterm-infants-neurodevelopmental-outcomes-at-22-26-months-of-corrected-age
#10
Anup Katheria, Donna Garey, Giang Truong, Natacha Akshoomoff, Jane Steen, Mauricio Maldonado, Debra Poeltler, Mary Jane Harbert, Yvonne E Vaucher, Neil Finer
OBJECTIVE: To compare the effect of umbilical cord milking vs delayed cord clamping (DCC) on neurodevelopmental and health outcomes in very preterm infants at 22-26 months of corrected age. STUDY DESIGN: Neurodevelopmental outcomes at 2 years of age were assessed using the Bayley Scales of Infant Development, third edition, and a standardized neurologic examination. Data regarding pulmonary morbidities, neurosensory impairments, and hospitalizations were obtained by parental interview...
December 7, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29233207/the-dynamic-pattern-of-plin3-in-pig-oocytes-and-cumulus-cells-during-in-vitro-maturation
#11
Mingzhu Xu, Yaqiong Zeng, Daming Chi, Linan Si, Xiao Qu, Juan Li
Lipid droplets (LDs) are the main energy resource for porcine preimplantation embryonic development. PLIN3 has been implicated in LD formation and regulation. Therefore, this study aimed to detect the dynamic pattern of PLIN3 in pig oocytes and cumulus cells (CC) during in vitro maturation (IVM), and to determine the relationship between PLIN3 and LD content. IVM with cumulus-enclosed oocytes (CEO), cumulus-denuded oocytes (DO) and the CCs denuded from the corresponding oocytes (DCC) was performed in porcine follicular fluid (PFF) or PFF-free optimized medium...
December 13, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/29222815/evaluation-and-comparison-of-2-on-farm-tests-for-estimating-somatic-cell-count-in-quarter-milk-samples-from-lactating-dairy-cattle
#12
S A Kandeel, A A Megahed, F K Arnaout, P D Constable
BACKGROUND: The somatic cell count (SCC) is commonly used to monitor udder health and diagnose subclinical intramammary infection (IMI) in dairy cattle. HYPOTHESIS: The Somaticell test (ST) and California mastitis test (CMT) are clinically useful cow-side tests for diagnosing subclinical IMI. ANIMALS: One hundred and eleven dairy cows at dry-off and 92 cows within 4-7 days postcalving. METHODS: Quarter foremilk samples were obtained and analyzed with a DeLaval cell counter (DCC, reference method), ST, and CMT...
December 9, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29221606/-medical-information-system-pmsi-does-not-adequately-identify-severe-trauma
#13
A Perozziello, T Gauss, A Diop, M Frank-Soltysiak, P Rufat, M Raux, S Hamada, B Riou
BACKGROUND: Resource allocation to hospitals is highly dependent on appropriate case coding. For trauma victims, the major diagnosis-coding category (DCC) is multiple trauma (DCC26), which triggers higher funding. We hypothesized that DCC26 has limited capacity for appropriate identification of severe trauma victims. METHODS: We studied Injury Severity Score (ISS), Trauma Related Injury Severity Score (TRISS) and in-hospital mortality using data recorded in three level 1 trauma centers over a 2-year period...
December 5, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/29208352/multicentre-study-of-the-impact-of-factors-that-may-affect-long-term-survival-following-pancreaticoduodenectomy-for-distal-cholangiocarcinoma
#14
Laëtitia Courtin-Tanguy, Olivier Turrini, Damien Bergeat, Stéphanie Truant, Benjamin Darnis, Jean R Delpero, Jean Y Mabrut, Nicolas Regenet, Laurent Sulpice
BACKGROUND: Although the peri-operative mortality following pancreaticoduodenectomy (PD) for distal cholangiocarcinoma (DCC) has decreased, the post-operative morbidity remains high. The aim of this study was to evaluate the impact of factors that may affect the long term survival for patients with DCC following PD. METHODS: All patients who underwent PD for DCC between January 2000 and December 2015 in 5 tertiary referral centers underwent retrospective medical record review...
December 2, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29202173/dcc-ntn1-complex-mutations-in-patients-with-congenital-hypogonadotropic-hypogonadism-impair-gnrh-neuron-development
#15
Justine Bouilly, Andrea Messina, Georgios Papadakis, Daniele Cassatella, Cheng Xu, James S Acierno, Brooke Tata, Gerasimos Sykiotis, Sara Santini, Yisrael Sidis, Eglantine Elowe-Gruau, Franziska Phan-Hug, Michael Hauschild, Pierre-Marc Bouloux, Richard Quinton, Mariarosaria Lang-Muritano, Lucie Favre, Laura Marino, Paolo Giacobini, Andrew A Dwyer, Nicolas J Niederländer, Nelly Pitteloud
Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic disease characterized by absent puberty and infertility due to GnRH deficiency, and is often associated with anosmia (Kallmann syndrome, KS). The genetic etiology of CHH is heterogeneous, and more than 30 genes have been implicated in approximately 50% of patients with CHH. We hypothesized that genes encoding axon-guidance proteins containing fibronectin type-III (FN3) domains (similar to ANOS1, the first gene associated with KS), are mutated in CHH...
November 30, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29193190/indoor-allergen-levels-in-settled-airborne-dust-are-higher-in-day-care-centers-than-at-home
#16
I Sander, A Lotz, H D Neumann, C Czibor, A Flagge, E Zahradnik, M Raulf
BACKGROUND: Early-life sensitization to indoor allergens predicts asthma development. The aim of this study was to compare allergen concentrations in day-care centers (DCC) with those in private homes. METHODS: Settled airborne dust was collected 4 times a year from 20 German DCC (620 samples) and from the homes of children and day-care workers (602 samples) using electrostatic dust collectors (EDC). The samples were analyzed with fluorescence enzyme immunoassays recognizing domestic mite allergens (DM), Fel d 1, Can f 1, and Mus m 1...
November 29, 2017: Allergy
https://www.readbyqxmd.com/read/29187730/genome-wide-analysis-in-uk-biobank-identifies-four-loci-associated-with-mood-instability-and-genetic-correlation-with-major-depressive-disorder-anxiety-disorder-and-schizophrenia
#17
Joey Ward, Rona J Strawbridge, Mark E S Bailey, Nicholas Graham, Amy Ferguson, Donald M Lyall, Breda Cullen, Laura M Pidgeon, Jonathan Cavanagh, Daniel F Mackay, Jill P Pell, Michael O'Donovan, Valentina Escott-Price, Daniel J Smith
Mood instability is a core clinical feature of affective and psychotic disorders. In keeping with the Research Domain Criteria approach, it may be a useful construct for identifying biology that cuts across psychiatric categories. We aimed to investigate the biological validity of a simple measure of mood instability and evaluate its genetic relationship with several psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD), schizophrenia, attention deficit hyperactivity disorder (ADHD), anxiety disorder and post-traumatic stress disorder (PTSD)...
November 30, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29183925/cohort-profile-the-truenth-global-registry-an-international-registry-to-monitor-and-improve-localised-prostate-cancer-health-outcomes
#18
Sue M Evans, Jeremy L Millar, Caroline M Moore, John D Lewis, Hartwig Huland, Fanny Sampurno, Sarah E Connor, Paul Villanti, Mark S Litwin
PURPOSE: Globally, prostate cancer treatment and outcomes for men vary according to where they live, their race and the care they receive. The TrueNTH Global Registry project was established as an international registry monitoring care provided to men with localised prostate cancer (CaP). PARTICIPANTS: Sites with existing CaP databases in Movember fundraising countries were invited to participate in the international registry. In total, 25 Local Data Centres (LDCs) representing 113 participating sites across 13 countries have nominated to contribute to the project...
November 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/29182216/adhesion-and-early-colonization-of-s-mutans-on-lithium-disilicate-reinforced-glass-ceramics-monolithic-zirconia-and-dual-cure-resin-cement
#19
L Viitaniemi, A Abdulmajeed, T Sulaiman, E Söderling, T Närhi
OBJECTIVE: Monolithic zirconia and glass ceramics are increasingly used in implant crowns. Limited data is available on bacterial adhesion and early biofilm formation on these materials. METHODS: Four different materials were investigated: (1) Lithium disilicate glass-ceramics (LDS), (2) Fully stabilized zirconia (FSZ), (3) Partially stabilized zirconia (PSZ), and (4) Dual curing cement (DCC). The materials' surfaces were characterized with spinning disc confocal microscopy and by water contact angle and surface free energy (SFE) measurements...
December 1, 2017: European Journal of Prosthodontics and Restorative Dentistry
https://www.readbyqxmd.com/read/29180027/nasopharyngeal-s-pneumoniae-carriage-and-density-in-belgian-infants-after-9%C3%A2-years-of-pneumococcal-conjugate-vaccine-programme
#20
Ine Wouters, Liesbet Van Heirstraeten, Stefanie Desmet, Stéphanie Blaizot, Jan Verhaegen, Herman Goossens, Pierre Van Damme, Surbhi Malhotra-Kumar, Heidi Theeten
BACKGROUND: In Belgium, the infant pneumococcal conjugate vaccine (PCV) programme changed from PCV7 (2007-2011) to PCV13 (2011-2015) and to PCV10 (2015-2016). A 3-year nasopharyngeal carriage study was initiated during the programme switch in 2016. Main objective of the year 1 assessment was to obtain a baseline measurement of pneumococcal carriage prevalence, carriage density, serotype distribution and antibiotic resistance. MATERIALS/METHODS: Two infant populations aged 6-30 months and without use of antibiotics in the seven days prior to sampling were approached: (1) attending one of 85 randomly selected day-care centres (DCC); (2) presenting with AOM at study-trained general practitioners and paediatricians...
November 24, 2017: Vaccine
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