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https://www.readbyqxmd.com/read/27929530/effects-of-delayed-cord-clamping-on-residual-placental-blood-volume-hemoglobin-and-bilirubin-levels-in-term-infants-a-randomized-controlled-trial
#1
J S Mercer, D A Erickson-Owens, J Collins, M O Barcelos, A B Parker, J F Padbury
OBJECTIVE: The objective of the study was to measure the effects of a 5-min delay (DCC) versus immediate cord clamping (ICC) on residual placental blood volume (RPBV) at birth, and hemoglobin and serum bilirubin at 24 to 48 h of age. STUDY DESIGN: In this prospective randomized controlled trial, 73 women with term (37 to 41 weeks) singleton fetuses were randomized to DCC (⩾5 min; n=37) or ICC (<20 s; n=36). RESULTS: Maternal and infant demographics were not different between the groups...
December 8, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27928953/novel-hybrid-molecules-on-the-basis-of-steroids-and-5z-9z-tetradeca-5-9-dienoic-acid-synthesis-anti-cancer-studies-and-human-topoisomerase-i-inhibitory-activity
#2
Vladimir A D Yakonov, Lilya U Dzhemileva, Regina A Tuktarova, Svetlana R Ishmukhametova, Milyausha M Yunusbaeva, Ilfir R Ramazanova, Usein M Dzhemilev
Novel steroid derivatives of 5Z,9Z-dienoic acids were prepared by the DCC/DMAP-catalyzed esterification of (5Z,9Z)-tetradeca-5,9-dienoic acid with hydroxy steroids. High cytotoxicity towards the HEK293, Jurkat, K562 cancer cell lines and human topoisomerase I (hTop1) inhibitory activity in vitro were found for the synthesized acids. A probable mechanism of topoisomerase I inhibition was hypothesized on the basis of in silico studies resorting to docking.
December 7, 2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27927766/phase-1-dose-finding-study-of-rebastinib-dcc-2036-in-patients-with-relapsed-chronic-myeloid-leukemia-and-acute-myeloid-leukemia
#3
Jorge Cortes, Moshe Talpaz, Hedy P Smith, David S Snyder, Jean Khoury, Kapil N Bhalla, Javier Pinilla-Ibarz, Richard Larson, David Mitchell, Scott C Wise, Thomas J Rutkoski, Bryan D Smith, Daniel L Flynn, Hagop M Kantarjian, Oliver Rosen, Richard A Van Etten
Available tyrosine kinase inhibitors for chronic myeloid leukemia bind in an ATP-binding pocket and are affected by evolving mutations that confer resistance. Rebastinib was identified as a switch control inhibitor of BCR-ABL1 and FLT3 and may be active against resistant mutations. A Phase 1, first in human, single-agent study investigated rebastinib in relapsed or refractory chronic or acute myeloid leukemia. Primary objectives were to investigate the safety of rebastinib and establish the maximum tolerated dose (MTD) and recommended Phase 2 dose...
December 7, 2016: Haematologica
https://www.readbyqxmd.com/read/27901020/structural-decoding-of-netrin-4-reveals-a-regulatory-function-towards-mature-basement-membranes
#4
Raphael Reuten, Trushar R Patel, Matthew McDougall, Nicolas Rama, Denise Nikodemus, Benjamin Gibert, Jean-Guy Delcros, Carina Prein, Markus Meier, Stéphanie Metzger, Zhigang Zhou, Jennifer Kaltenberg, Karen K McKee, Tobias Bald, Thomas Tüting, Paola Zigrino, Valentin Djonov, Wilhelm Bloch, Hauke Clausen-Schaumann, Ernst Poschl, Peter D Yurchenco, Martin Ehrbar, Patrick Mehlen, Jörg Stetefeld, Manuel Koch
Netrins, a family of laminin-related molecules, have been proposed to act as guidance cues either during nervous system development or the establishment of the vascular system. This was clearly demonstrated for netrin-1 via its interaction with the receptors DCC and UNC5s. However, mainly based on shared homologies with netrin-1, netrin-4 was also proposed to play a role in neuronal outgrowth and developmental/pathological angiogenesis via interactions with netrin-1 receptors. Here, we present the high-resolution structure of netrin-4, which shows unique features in comparison with netrin-1, and show that it does not bind directly to any of the known netrin-1 receptors...
November 30, 2016: Nature Communications
https://www.readbyqxmd.com/read/27871482/push-out-bond-strength-of-fiber-posts-to-intraradicular-dentin-using-multimode-adhesive-system
#5
Siavash Savadi Oskoee, Mahmoud Bahari, Soodabeh Kimyai, Saeed Asgary, Katayoun Katebi
INTRODUCTION: Because there is little information about bond strength of fiber posts cemented with a universal adhesive system (UAS) with different resin cements, the aim of this study was to compare the effect of different bonding strategies in the application of UASs on push-out bond strength of fiber posts to intraradicular dentin. METHODS: Seventy-two single-rooted teeth were randomly divided into 6 groups: self-adhesive resin cement (SAC), dual-cure resin cement (DCC), UAS in the etch-and-rinse (E&R) mode and SAC (E&R + SAC), UAS in the self-etch (SE) mode and SAC (SE + SAC), UAS in the E&R mode and DCC (E&R + DCC), and UAS in the SE mode and DCC (SE + DCC)...
December 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27870078/cartilage-extracellular-matrix-as-a-biomaterial-for-cartilage-regeneration
#6
Emi A Kiyotake, Emily C Beck, Michael S Detamore
The extracellular matrix (ECM) of various tissues possesses the model characteristics that biomaterials for tissue engineering strive to mimic; however, owing to the intricate hierarchical nature of the ECM, it has yet to be fully characterized and synthetically fabricated. Cartilage repair remains a challenge because the intrinsic properties that enable its durability and long-lasting function also impede regeneration. In the last decade, cartilage ECM has emerged as a promising biomaterial for regenerating cartilage, partly because of its potentially chondroinductive nature...
November 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27863273/effects-of-delayed-cord-clamping-on-the-third-stage-of-labour-maternal-haematological-parameters-and-acid-base-status-in-fetuses-at-term
#7
Catalina De Paco, Javier Herrera, Carolina Garcia, Shiana Corbalán, Alicia Arteaga, Miriam Pertegal, Rosario Checa, María Teresa Prieto, Aníbal Nieto, Juan Luis Delgado
OBJECTIVE: To compare the time in the third stage of labour, differences in maternal hematologic parameters 48h after birth and acid-base status in the umbilical cord between the early cord clamping (ECC) and delayed cord clamping (DCC). STUDY DESIGN: 97 healthy pregnancies at term and a spontaneous vertex delivery at Clinic University Hospital "Virgen de la Arrixaca" (Murcia, Spain), were randomized to ECC group (<10s post-delivery) or to DCC group (2min post-delivery)...
November 9, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27863093/potential-effect-of-mechano-growth-factor-e-domain-peptide-on-axonal-guidance-growth-in-primary-cultured-cortical-neurons-of-rats
#8
Meili Liu, Xufeng Niu, Gang Zhou, Zhengtai Jia, Ping Li, Yubo Fan
Establishing appropriate synaptic connections and plasticity is a critical need in neuronal regeneration and development. Mechano growth factor (MGF) and its C-terminal E-domain peptide with 24 amino acids, MGF-Ct24E, are potential neuroprotective agents. Our preliminary study indicates that Netrin-1 can guide axonal growth and its expression is sensitive to MGF, but how MGF regulates the expression of Netrin-1 and its receptor DCC is still unclear. Here, we investigate the effect of MGF-Ct24E on the expression of Netrin-1 and DCC in primary cultured cortical neurons in vitro and the adult rat brain in vivo...
November 15, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27860037/the-impact-of-physicians-communication-styles-on-evaluation-of-physicians-and-information-processing-a-randomized-study-with-simulated-video-consultations-on-contraception-with-an-intrauterine-device
#9
Martina Bientzle, Tim Fissler, Ulrike Cress, Joachim Kimmerle
OBJECTIVE: This study aimed at examining the impact of different types of physicians' communication styles on people's subsequent evaluation of physician attributes as well as on their information processing, attitude and decision making. METHOD: In a between-group experiment, 80 participants watched one of three videos in which a gynaecologist displayed a particular communication style in a consultation situation on contraception with an intrauterine device. We compared doctor-centred communication (DCC) vs patient-centred communication (PCC) vs patient-centred communication with need-orientation (PCC-N)...
November 18, 2016: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/27846450/folic-acid-and-trastuzumab-conjugated-redox-responsive-random-multiblock-copolymeric-nanocarriers-for-breast-cancer-therapy-in-vitro-and-in-vivo-studies
#10
Arun Kumar, Shantanu V Lale, M R Aji Alex, Veena Choudhary, Veena Koul
The study represents synthesis, characterization and biological evaluation of redox responsive polymeric nanoparticles based on random multiblock copolymer for doxorubicin delivery in breast cancer. The random multiblock copolymer was synthesized via ring opening polymerization of lactide with polyethylene glycol to form triblock copolymer followed by isomerization polymerization of the triblock copolymer and 2-hydroxyethyl disulfide with the help of hexamethylene diisocynate in presence of dibutyltin dilaurate as a catalyst...
November 6, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27830107/congenital-mirror-movements-due-to-rad51-cosegregation-with-a-nonsense-mutation-in-a-norwegian-pedigree-and-review-of-the-literature
#11
Oriane Trouillard, Jeanette Koht, Thorsten Gerstner, Siri Moland, Christel Depienne, Isabelle Dusart, Aurélie Méneret, Marta Ruiz, Caroline Dubacq, Emmanuel Roze
BACKGROUND: Autosomal dominant congenital mirror movements (CMM) is a neurodevelopmental disorder characterized by early onset involuntary movements of one side of the body that mirror intentional movements on the contralateral side; these persist throughout life in the absence of other neurological symptoms. The main culprit genes responsible for this condition are RAD51 and DCC. This condition has only been reported in a few families, and the molecular mechanisms linking RAD51 mutations and mirror movements (MM) are poorly understood...
2016: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/27830043/phase-ii-study-of-docetaxel-cisplatin-and-capecitabine-as-preoperative-chemotherapy-in-resectable-gastric-cancer
#12
Anneriet E Dassen, Nienke Bernards, Valery E P P Lemmens, Yes A J van de Wouw, Koop Bosscha, Geert-Jan Creemers, Hans J F M Pruijt
AIM: To investigate the feasibility of preoperative docetaxel, cisplatin and capecitabine (DCC) in patients with resectable gastric cancer. METHODS: Patients with resectable gastric cancer fulfilling the inclusion criteria, were treated with 4 cycles of docetaxel (60 mg/m(2)), cisplatin (60 mg/m(2)) and capecitabine (1.875 mg/m(2) orally on day 1-14, two daily doses) repeated every three weeks, followed by surgery. Primary end point was the feasibility and toxicity/safety profile of DCC, secondary endpoints were pathological complete resection rate and pathological complete response (pCR) rate...
October 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27829920/dna-functionalization-by-dynamic-chemistry
#13
Zeynep Kanlidere, Oleg Jochim, Marta Cal, Ulf Diederichsen
Dynamic combinatorial chemistry (DCC) is an attractive method to efficiently generate libraries of molecules from simpler building blocks by reversible reactions under thermodynamic control. Here we focus on the chemical modification of DNA oligonucleotides with acyclic diol linkers and demonstrate their potential for the deoxyribonucleic acid functionalization and generation of libraries of reversibly interconverting building blocks. The syntheses of phosphoramidite building blocks derived from D-threoninol are presented in two variants with protected amino or thiol groups...
2016: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27826008/functional-rescue-of-abcc6-deficiency-by-4-phenylbutyrate-therapy-reduces-dystrophic-calcification-in-abcc6-mice
#14
Viola Pomozi, Christopher Brampton, Flóra Szeri, Dóra Dedinszki, Eszter Kozák, Koen van de Wetering, Hi'ilani Hopkins, Ludovic Martin, András Váradi, Olivier Le Saux
Soft tissue calcification is associated with aging, common conditions such as diabetes or hypercholesterolemia and with certain genetic disorders. ABCC6 is an efflux transporter primarily expressed in liver facilitating the release of ATP from hepatocytes. Within the liver vasculature, ATP is converted into pyrophosphate (PPi), a major inhibitor of ectopic calcification. ABCC6 mutations thus lead to reduced plasma PPi levels resulting in the calcification disorder pseudoxanthoma elasticum (PXE) and some cases of generalized arterial calcification of infancy (GACI)...
November 5, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27807633/-pancreatic-acinar-neoplasms-comparative-molecular-characterization
#15
F Bergmann
Pancreatic acinar cell carcinomas are biologically aggressive neoplasms for which treatment options are very limited. The molecular mechanisms of tumor initiation and progression are largely not understood and precursor lesions have not yet been identified. In this study, pancreatic acinar cell carcinomas were cytogenetically characterized as well as by molecular and immunohistochemical analyses. Corresponding investigations were carried out on pancreatic ductal adenocarcinomas and pancreatic neuroendocrine neoplasms augmented by functional analyses...
November 2016: Der Pathologe
https://www.readbyqxmd.com/read/27802200/modern-molecular-biomarkers-of-head-and-neck-cancer-part-i-epigenetic-diagnostics-and-prognostics-systematic-review
#16
Gintaras Juodzbalys, David Kasradze, Marco Cicciù, Aurimas Sudeikis, Laurynas Banys, Pablo Galindo-Moreno, Zygimantas Guobis
INTRODUCTION: Nearly half of the head and neck cancer cases are diagnosed in late stages. Traditional screening modalities have many disadvantages. The aim of the present article was to review the scientific literature about novel head and neck cancer diagnostics - epigenetic biomarkers. EVIDENCE ACQUISITION: A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database. Authors conducted the search of articles in English language published from 2004 to 2015...
September 30, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27793362/netrin-1-a-regulator-of-cancer-cell-motility
#17
Irene Ylivinkka, Jorma Keski-Oja, Marko Hyytiäinen
Netrins form a family of secreted and membrane-associated proteins, netrin-1 being the prototype and most investigated member of the family. The major physiological functions of netrin-1 lie in the regulation of axonal development as well as morphogenesis of different branched organs, by promoting the polarity of migratory/invasive front of the cell. On the other hand, netrin-1 acts as a factor preventing cell apoptosis. These events are mediated via a range of different receptors, including UNC5 and DCC-families...
October 19, 2016: European Journal of Cell Biology
https://www.readbyqxmd.com/read/27792703/-percutaneous-intervention-in-the-correction-of-congenital-heart-deffects-dcc-experience-in-as-umae
#18
Vicente Campos-García, Guillermo Ordóñez-Toquero, Sarain Monjaraz-Rodríguez, Eduardo Gómez-Conde
INTRODUCTION: Congenital heart defects are common in infants and adults, affecting quality of life if not corrected. Unlike open surgery, percutaneous intervention allows correction with a high success rate and speedy recovery. In Mexico, there are not enough studies to describe their efficacy and safety. METHODS: A cohort study was conducted in the Hospital "Manuel Avila Camacho", in Puebla, Mexico, including 149 patients with congenital heart defects repaired by percutaneous intervention, recording data from clinical records...
September 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27789683/esbl-ampc-producing-enterobacteriaceae-in-households-with-children-of-preschool-age-prevalence-risk-factors-and-co-carriage
#19
G van den Bunt, A Liakopoulos, D J Mevius, Y Geurts, A C Fluit, M J M Bonten, L Mughini-Gras, W van Pelt
OBJECTIVES: ESBL/AmpC-producing Enterobacteriaceae are an emerging public health concern. As households with preschool children may substantially contribute to the community burden of antimicrobial resistance, we determined the prevalence, risk factors and co-carriage of ESBL/AmpC-producing bacteria in preschool children and their parents. METHODS: From April 2013 to January 2015, each month 2000 preschool children were randomly selected from Dutch population registries...
October 26, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27784329/netrin1-dcc-signaling-promotes-neuronal-migration-in-the-dorsal-spinal-cord
#20
Harald J Junge, Andrea R Yung, Lisa V Goodrich, Zhe Chen
BACKGROUND: Newborn neurons often migrate before undergoing final differentiation, extending neurites, and forming synaptic connections. Therefore, neuronal migration is crucial for establishing neural circuitry during development. In the developing spinal cord, neuroprogenitors first undergo radial migration within the ventricular zone. Differentiated neurons continue to migrate tangentially before reaching the final positions. The molecular pathways that regulate these migration processes remain largely unknown...
October 26, 2016: Neural Development
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