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https://www.readbyqxmd.com/read/29027522/-morphochemical-changes-in-the-substantia-nigra-cellular-structures-in-parkinson-s-disease
#1
V N Salkov, R M Khudoerkov, D N Voronkov, V B Sobolev, K A Kutukova
AIM: to clarify the features of morphochemical changes in the substantia nigra cellular structures in Parkinson's disease. MATERIAL AND METHODS: The structural characteristics of the substantia nigra were studied microscopically and quantified using computer morphometric methods at brain autopsies of individuals with Parkinson's disease who had died from intercurrent diseases and those who had no evidence of neurological disorders in their history (a control group)...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/29021778/the-combined-quantification-and-interpretation-of-multiple-quantitative-magnetic-resonance-imaging-metrics-enlightens-longitudinal-changes-compatible-with-brain-repair-in-relapsing-remitting-multiple-sclerosis-patients
#2
Guillaume Bonnier, Benedicte Maréchal, Mário João Fartaria, Pavel Falkowskiy, José P Marques, Samanta Simioni, Myriam Schluep, Renaud Du Pasquier, Jean-Philippe Thiran, Gunnar Krueger, Cristina Granziera
OBJECTIVE: Quantitative and semi-quantitative MRI (qMRI) metrics provide complementary specificity and differential sensitivity to pathological brain changes compatible with brain inflammation, degeneration, and repair. Moreover, advanced magnetic resonance imaging (MRI) metrics with overlapping elements amplify the true tissue-related information and limit measurement noise. In this work, we combined multiple advanced MRI parameters to assess focal and diffuse brain changes over 2 years in a group of early-stage relapsing-remitting MS patients...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29020889/differential-effect-of-acute-iron-overload-on-oxidative-status-and-antioxidant-content-in-regions-of-rat-brain
#3
Natacha E Piloni, Macarena Reiteri, Marcelo P Hernando, Claudio O Cervino, Susana Puntarulo
The hypothesis of this study is that the cerebral cortex, hippocampus, and striatum of the rat brain are differentially affected in terms of oxidative stress and antioxidant capacity by acute Fe overload because Fe is distributed in a heterogeneous fashion among different regions and cells of the brain. The effects on the lipophilic and hydrophilic cellular environment were compared between regions and with the whole brain. A single dose of Fe-dextran increased Fe deposits, reaching a maximum after 6 hr. Both in whole brain and in cortex region, the ascorbyl/ascorbate content ratio was increased after 6 hr of Fe administration, while in striatum and hippocampus, there was no significant changes after Fe overload...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/29016618/nigrosome-1-visibility-at-susceptibility-weighted-7t-mri-a-dependable-diagnostic-marker-for-parkinson-s-disease-or-merely-an-inconsistent-age-dependent-imaging-finding
#4
Carolin Gramsch, Iris Reuter, Oliver Kraff, Harald H Quick, Christian Tanislav, Florian Roessler, Cornelius Deuschl, Michael Forsting, Marc Schlamann
BACKGROUND: Visualisation of nigrosome 1, a substructure of the healthy substantia nigra, was restricted in susceptibility weighted MR imaging in almost all patients with Parkinson's disease studied so far. The purpose of this study was to determine the degree of visibility of this substructure in subjects without Parkinson's disease and to examine the potential link between increasing brain iron accumulation with age and its detectability. METHODS: In 46 subjects (21 women, 25 men; 19 to 75 y; mean age: 44...
2017: PloS One
https://www.readbyqxmd.com/read/28991683/a-new-pla2g6-mutation-in-a-family-with-infantile-neuroaxonal-dystrophy
#5
Iannello Grazia, Graziano Claudio, Cenacchi Giovanna, Cordelli Duccio Maria, Zuntini Roberta, Papa Valentina, Magistà Anna Maria, Gagliardi Monica, Procopio Radha, Quattrone Aldo, Annesi Grazia
Phospholipase A2-associated neurodegeneration (PLAN), a syndrome of Neurodegeneration with Brain Iron Accumulation (NBIA), is an autosomal recessive disorder caused by mutations in PLA2G6 gene. This gene encodes a calcium-independent group VI phospholipase A2 (iPLA-VI) critical in cell membrane homeostasis. PLAN syndrome encompasses a group of phenotypes with a different age of onset: classic infantile neuroaxonal dystrophy (INAD), atypical neuroaxonal dystrophy of childhood-onset (atypical NAD) and adult-onset PLA2G6-related dystonia-parkinsonism (PARK14)...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28990041/brain-iron-deposition-analysis-using-susceptibility-weighted-imaging-and-its-association-with-body-iron-level-in-patients-with-mild-cognitive-impairment
#6
Lili Gao, Zhihong Jiang, Zhaocheng Cai, Ming Cai, Qing Zhang, Yingying Ma, Guoliang Li, Fengzhu Zhao, Qiang Ma
The aim of the present study was to analyze brain and body iron levels among patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and normal controls (NCs). A total of 90 participants (30 MCI, 30 AD, 30 NC) were enrolled. Brain iron content was quantified using susceptibility weighted imaging (SWI). Phase values were used to calculate bilateral iron content in the hippocampus (HP), substantia nigra, red nucleus (RN), dentate nucleus (DN), caudate nucleus (CN), globus pallidus (GP), putamen (PUT), frontal white matter, temporal cortex (TC), and parietal cortex...
September 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28988390/topographic-distribution-of-brain-iron-deposition-and-small-cerebrovascular-lesions-in-amyotrophic-lateral-sclerosis-and-in-frontotemporal-lobar-degeneration-a-post-mortem-7-0-tesla-magnetic-resonance-imaging-study-with-neuropathological-correlates
#7
Jacques De Reuck, David Devos, Caroline Moreau, Florent Auger, Nicolas Durieux, Vincent Deramecourt, Florence Pasquier, Claude-Alain Maurage, Charlotte Cordonnier, Didier Leys, Regis Bordet
Amyotrophic lateral sclerosis (ALS) is associated with frontotemporal lobar degeneration (FTLD) in 15% of the cases. A neuropathological continuity between ALS and FTLD-TDP is suspected. The present post-mortem 7.0-tesla magnetic resonance imaging (MRI) study compares the topographic distribution of iron (Fe) deposition and the incidence of small cerebrovascular lesions in ALS and in FTLD brains. Seventy-eight post-mortem brains underwent 7.0-tesla MRI. The patients consisted of 12 with ALS, 38 with FTLD, and 28 controls...
October 7, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28987166/neurodegeneration-with-brain-iron-accumulation
#8
Sarah Wiethoff, Henry Houlden
Neurodegeneration with brain iron accumulation (NBIA) describes a heterogeneous group of inherited rare clinical and genetic entities. Clinical core symptoms comprise a combination of early-onset dystonia, pyramidal and extrapyramidal signs with ataxia, cognitive decline, behavioral abnormalities, and retinal and axonal neuropathy variably accompanying these core features. Increased nonphysiologic, nonaging-associated brain iron, most pronounced in the basal ganglia, is often termed the unifying characteristic of these clinically variable disorders, though occurrence and extent can be fluctuating or even absent...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28985560/ferroptosis-a-regulated-cell-death-nexus-linking-metabolism-redox-biology-and-disease
#9
REVIEW
Brent R Stockwell, José Pedro Friedmann Angeli, Hülya Bayir, Ashley I Bush, Marcus Conrad, Scott J Dixon, Simone Fulda, Sergio Gascón, Stavroula K Hatzios, Valerian E Kagan, Kay Noel, Xuejun Jiang, Andreas Linkermann, Maureen E Murphy, Michael Overholtzer, Atsushi Oyagi, Gabriela C Pagnussat, Jason Park, Qitao Ran, Craig S Rosenfeld, Konstantin Salnikow, Daolin Tang, Frank M Torti, Suzy V Torti, Shinya Toyokuni, K A Woerpel, Donna D Zhang
Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of polyunsaturated fatty acids into cellular membranes, and cells have developed complex systems that exploit and defend against this vulnerability in different contexts. The sensitivity to ferroptosis is tightly linked to numerous biological processes, including amino acid, iron, and polyunsaturated fatty acid metabolism, and the biosynthesis of glutathione, phospholipids, NADPH, and coenzyme Q10...
October 5, 2017: Cell
https://www.readbyqxmd.com/read/28982612/brain-regional-iron-contents-in-progressive-supranuclear-palsy
#10
Seung Ha Lee, Chul Hyoung Lyoo, Sung Jun Ahn, Juha O Rinne, Myung Sik Lee
INTRODUCTION: To determine motor-related brain regions in which iron contents correlate with the degree of motor deficits of progressive supranuclear palsy (PSP). METHODS: Twenty-four patients with probable PSP and 20 controls were included. Using a 3.0T magnetic resonance imaging scanner, R2* values were measured in the putamen, globus pallidus (GP), substantia nigra (SN), subthalamic nucleus, and dentate nucleus. After adjustment for disease duration and age at examination, correlations between regional brain R2* values and Unified Parkinson Disease Rating Scale (UPDRS) total motor scores or subscores for bradykinesia, rigidity, tremor, or axial motor deficits were investigated...
September 28, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28976180/magnetic-particle-imaging-for-real-time-perfusion-imaging-in-acute-stroke
#11
Peter Ludewig, Nadine Gdaniec, Jan Sedlacik, Nils D Forkert, Patryk Szwargulski, Matthias Graeser, Gerhard Adam, Michael G Kaul, Kannan M Krishnan, R Matthew Ferguson, Amit P Khandhar, Piotr Walczak, Jens Fiehler, Götz Thomalla, Christian Gerloff, Tobias Knopp, Tim Magnus
The fast and accurate assessment of cerebral perfusion is fundamental for the diagnosis and successful treatment of stroke patients. Magnetic particle imaging (MPI) is a new radiation-free tomographic imaging method with a superior temporal resolution, compared to other conventional imaging methods. In addition, MPI scanners can be built as prehospital mobile devices, which require less complex infrastructure than computed tomography (CT) and magnetic resonance imaging (MRI). With these advantages, MPI could accelerate the stroke diagnosis and treatment, thereby improving outcomes...
October 4, 2017: ACS Nano
https://www.readbyqxmd.com/read/28974951/nutritional-immunity-triggers-the-modulation-of-iron-metabolism-genes-in-the-sub-antarctic-notothenioid-eleginops-maclovinus-in-response-to-piscirickettsia-salmonis
#12
Danixa Martínez, Ricardo Oyarzún, Juan Pablo Pontigo, Alex Romero, Alejandro J Yáñez, Luis Vargas-Chacoff
Iron deprivation is a nutritional immunity mechanism through which fish can limit the amount of iron available to invading bacteria. The aim of this study was to evaluate the modulation of iron metabolism genes in the liver and brain of sub-Antarctic notothenioid Eleginops maclovinus challenged with Piscirickettsia salmonis. The specimens were inoculated with two P. salmonis strains: LF-89 (ATCC(®) VR-1361™) and Austral-005 (antibiotic resistant). Hepatic and brain samples were collected at intervals over a period of 35 days...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28973554/neurovascular-unit-basic-and-clinical-imaging-with-emphasis-on-advantages-of-ferumoxytol
#13
Joao Prola Netto, Jeffrey Iliff, Danica Stanimirovic, Kenneth A Krohn, Bronwyn Hamilton, Csanad Varallyay, Seymur Gahramanov, Heike Daldrup-Link, Christopher d'Esterre, Berislav Zlokovic, Haris Sair, Yueh Lee, Saeid Taheri, Rajan Jain, Ashok Panigrahy, Daniel S Reich, Lester R Drewes, Mauricio Castillo, Edward A Neuwelt
Physiological and pathological processes that increase or decrease the central nervous system's need for nutrients and oxygen via changes in local blood supply act primarily at the level of the neurovascular unit (NVU). The NVU consists of endothelial cells, associated blood-brain barrier tight junctions, basal lamina, pericytes, and parenchymal cells, including astrocytes, neurons, and interneurons. Knowledge of the NVU is essential for interpretation of central nervous system physiology and pathology as revealed by conventional and advanced imaging techniques...
July 21, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28965494/the-impacts-of-maternal-iron-deficiency-and-being-overweight-during-pregnancy-on-neurodevelopment-of-the-offspring
#14
Staffan K Berglund, Francisco J Torres-Espínola, Luz García-Valdés, Mª Teresa Segura, Cristina Martínez-Zaldívar, Carmen Padilla, Ricardo Rueda, Miguel Pérez García, Harry J McArdle, Cristina Campoy
Both maternal Fe deficiency (ID) and being overweight or obese (Ow/Ob, BMI≥25 kg/m2) may negatively affect offspring brain development. However, the two risk factors correlate and their independent effects on infant neurodevelopment are unclear. PREOBE is a prospective observational study that included 331 pregnant Spanish women, of whom 166 had pre-gestational Ow/Ob. Fe status was analysed at 34 weeks and at delivery, and babies were assessed using Bayley III scales of neurodevelopment at 18 months. In confounder-adjusted analyses, maternal ID at 34 weeks was associated with lower composite motor scores at 18 months (mean 113·3 (sd 9·9) v...
October 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28963052/deferoxamine-enhances-alternative-activation-of-microglia-and-inhibits-amyloid-beta-deposits-in-app-ps1-mice
#15
Yun Zhang, Mao-Lin He
The neurotoxicity of amyloid-β peptide (Aβ), a predominant histopathological hallmark lesion of Alzheimer's disease (AD), is enhanced by iron, as found in amyloid plaques of Alzheimer's disease (AD) patients. We investigated whether deferoxamine (DFX) treatment promotes functional recovery and tissue repair in APP/PS1 double transgenic mice. Twelve-month-old APP/PS1 mice were randomly divided into two groups (APP/PS1 and DFX). Neurological deficits were monitored for 2 weeks following DFX treatment. To characterize the activation of the microglia, expression of the M1 and M2 phenotypes was analyzed by immunohistochemistry and immunoblotting...
September 26, 2017: Brain Research
https://www.readbyqxmd.com/read/28959621/health-effects-following-subacute-exposure-to-geogenic-dust-collected-from-active-drainage-surfaces-nellis-dunes-recreation-area-las-vegas-nv
#16
Jamie C DeWitt, Brenda J Buck, Dirk Goossens, Yuanxin Teng, James Pollard, Brett T McLaurin, Russell Gerads, Deborah E Keil
The specific health effects of direct inhalation of fine minerogenic dusts generated by natural soil surfaces remain poorly known and relatively little researched. To learn more about this exposure and its contribution to human health effects, we surveyed surface sediment and characterized dust from the Nellis Dunes Recreation Area (NDRA) in Clark County, Nevada, a popular off-road vehicle (ORV) recreational site. Dry drainage systems at NDRA are commonly used as natural trail systems for ORV recreation; these surfaces also are characterized by high concentrations of heavy metals...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28959481/brain-iron-overload-following-intracranial-haemorrhage
#17
REVIEW
Thomas Garton, Richard F Keep, Ya Hua, Guohua Xi
Intracranial haemorrhages, including intracerebral haemorrhage (ICH), intraventricular haemorrhage (IVH) and subarachnoid haemorrhage (SAH), are leading causes of morbidity and mortality worldwide. In addition, haemorrhage contributes to tissue damage in traumatic brain injury (TBI). To date, efforts to treat the long-term consequences of cerebral haemorrhage have been unsatisfactory. Incident rates and mortality have not showed significant improvement in recent years. In terms of secondary damage following haemorrhage, it is becoming increasingly apparent that blood components are of integral importance, with haemoglobin-derived iron playing a major role...
December 2016: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/28955258/don-t-get-me-wrong-erp-evidence-from-cueing-communicative-intentions
#18
Stefanie Regel, Thomas C Gunter
How to make sure that one's utterances are understood as intended when not facing each other? In order to convey communicative intentions, in digital communication emoticons and pragmatic cues are frequently used. Such cueing becomes even more crucial for implied interpretations (e.g., irony) that cannot be understood literally, but require extra information. Sentences, such as 'That's fantastic,' may achieve either a literal or ironic meaning depending on the contextual constraints. In two experiments using event-related brain potentials (ERPs), we examined the effects of cueing communicative intentions (i...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28954841/consumption-of-iron-biofortified-beans-positively-affects-cognitive-performance-in-18-to-27-year-old-rwandan-female-college-students-in-an-18-week-randomized-controlled-efficacy-trial
#19
Laura E Murray-Kolb, Michael J Wenger, Samuel P Scott, Stephanie E Rhoten, Mercy G Lung'aho, Jere D Haas
Background: Evidence shows that iron deficiency in adulthood may affect cognitive performance, possibly by disrupting neurotransmitter regulation or brain energy metabolism. Women of reproductive age (WRA) are among those who are most vulnerable to iron deficiency; however, they have been largely ignored in the literature relating iron status to cognition.Objective: Our aim was to determine the efficacy of iron-biofortified beans in improving cognition in WRA compared with control beans.Methods: A double-blind, randomized intervention study was conducted in 150 women aged 18-27 y with low iron status (ferritin <20 μg/L)...
September 27, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28947494/the-interocc-case-control-study-risk-of-meningioma-and-occupational-exposure-to-selected-combustion-products-dusts-and-other-chemical-agents
#20
Damien M McElvenny, Martie van Tongeren, Michelle C Turner, Geza Benke, Jordi Figuerola, Sarah Fleming, Martine Hours, Laurel Kincl, Daniel Krewski, Dave McLean, Marie-Élise Parent, Lesley Richardson, Brigitte Schlehofer, Klaus Schlaefer, Siegal Sadetzki, Joachim Schüz, Jack Siemiatycki, Elisabeth Cardis
BACKGROUND: Little is known about occupational risk factors for meningioma. OBJECTIVES: To study whether risk of meningioma is associated with several occupational exposures, including selected combustion products, dusts and other chemical agents. METHODS: The INTEROCC study was an international case-control study of brain cancer conducted in seven countries. Data collection by interview included lifetime occupational histories. A job exposure matrix was used to derive estimates of exposure for the 12 agents...
September 25, 2017: Occupational and Environmental Medicine
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