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https://www.readbyqxmd.com/read/29138205/long-term-prognosis-of-young-breast-cancer-patients-%C3%A2-40-years-who-did-not-receive-adjuvant-systemic-treatment-protocol-for-the-paradigm-initiative-cohort-study
#1
Gwen Mhe Dackus, Natalie D Ter Hoeve, Mark Opdam, Willem Vreuls, Zsuzsanna Varga, Esther Koop, Stefan M Willems, Carolien Hm Van Deurzen, Emilie J Groen, Alicia Cordoba, Jos Bart, Antien L Mooyaart, Jan G van den Tweel, Vicky Zolota, Jelle Wesseling, Anna Sapino, Ewa Chmielik, Ales Ryska, Frederic Amant, Annegien Broeks, Ron Kerkhoven, Nikolas Stathonikos, Mitko Veta, Adri Voogd, Katarzyna Jozwiak, Michael Hauptmann, Marlous Hoogstraat, Marjanka K Schmidt, Gabe Sonke, Elsken van der Wall, Sabine Siesling, Paul J van Diest, Sabine C Linn
INTRODUCTION: Currently used tools for breast cancer prognostication and prediction may not adequately reflect a young patient's prognosis or likely treatment benefit because they were not adequately validated in young patients. Since breast cancers diagnosed at a young age are considered prognostically unfavourable, many treatment guidelines recommend adjuvant systemic treatment for all young patients. Patients cured by locoregional treatment alone are, therefore, overtreated. Lack of prognosticators for young breast cancer patients represents an unmet medical need and has led to the initiation of the PAtients with bReAst cancer DIaGnosed preMenopausally (PARADIGM) initiative...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29108301/cost-and-cost-effectiveness-of-adjuvant-trastuzumab-in-the-real-world-setting-a-study-of-the-southeast-netherlands-breast-cancer-consortium
#2
Shanly C Seferina, Bram L T Ramaekers, Maaike de Boer, M Wouter Dercksen, Franchette van den Berkmortel, Roel J W van Kampen, Agnès J van de Wouw, Adri C Voogd, Vivianne C G Tjan Heijnen, Manuela A Joore
Background: We assessed the real world costs and cost-effectiveness of the addition of trastuzumab in HER2 positive early breast cancer compared to chemotherapy alone in the Dutch daily practice as opposed to the results based on trial data and based on a subset of patients that were treated according to the guidelines. Patients and Methods: In a cohort study, we included all patients with stage I-III invasive breast cancer treated with curative intent in 5 Dutch hospitals between 2005 and 2007 (n=2684)...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29083086/polymerization-shrinkage-and-porosity-profile-of-dual-cure-dental-resin-cements-with-different-adhesion-to-dentin-mechanisms
#3
Adrieli Burey, Paulo José Dos Reis, Bruno Luiz Santana Vicentin, Cássia Cilene Dezan Garbelini, Márcio Grama Hoeppner, Carlos Roberto Appoloni
This research aims to probe the porosity profile and polymerization shrinkage of two different dual cure resin cements with different dentin bonding systems. The self-adhesive resin cement RelyX U200 (named RU) and the conventional Allcem Core (named AC) were analyzed by x-ray microtomography (μCT) and Scanning Electron Microscopy (SEM). Each cement was divided into two groups (n = 5): dual-cured (RUD and ACD) and self-cured (RUC and ACC). μCT demonstrated that the method of polymerization does not influence the porosity profile but the polymerization shrinkage...
October 30, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29082428/social-skills-training-and-adhd-what-works
#4
REVIEW
Amori Yee Mikami, Sophie Smit, Adri Khalis
PURPOSE OF REVIEW: Many children and adolescents with attention-deficit/hyperactivity disorder (ADHD) have difficulties in their social skills and peer relationships. Because social problems exacerbate later maladjustment in ADHD populations, it is important to address this serious impairment. Although social skills training (SST) is a common intervention approach, evidence to date suggests that SST has limited efficacy, at least when provided in traditional, clinic-based settings. The current review summarizes recent advances to traditional SST approaches that may potentially enhance their efficacy...
October 30, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29058916/resolubilization-of-protein-from-water-insoluble-phlorotannin-protein-complexes-upon-acidification
#5
Anne M Vissers, Annelies E Blok, Adrie H Westphal, Wouter H Hendriks, Harry Gruppen, Jean-Paul Vincken
Marine phlorotannins (PhT) from Laminaria digitata might protect feed proteins from ruminal digestion by formation of insoluble non-covalent tannin-protein complexes at rumen pH (6-7). Formation and disintegration of PhT-protein complexes was studied with β-casein (random coil) and bovine serum albumin (BSA, globular) at various pH. PhT had similar binding affinity for β-casein and BSA as pentagalloyl glucose, as studied by fluorescence quenching. The affinity of PhT for both proteins was independent of pH (3...
November 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28981284/development-of-a-reaxff-force-field-for-cu-s-c-h-and-reactive-md-simulations-of-methyl-thiolate-decomposition-on-cu-100
#6
Jejoon Yeon, Heather L Adams, Chad E Junkermeier, Adri C T van Duin, Wilfred T Tysoe, Ashlie Martini
It has been shown that the rate of decomposition of methyl thiolate species on copper is accelerated by sliding on a methyl thiolate covered surface in ultrahigh vacuum at room temperature. The reaction produces small gas-phase hydrocarbons and deposits sulfur on the surface. Here, a new ReaxFF potential was developed to enable investigation of the molecular processes that induce this mechanochemical reaction by using density functional theory calculations to tune force field parameters for the model system...
October 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28941261/elsevier%C3%A2-s-citescore-index-values-for-acta-dermatovenerologica-alpina-pannonica-et-adriatica-a-2016-update
#7
Anja Šterbenc, Anja Oštrbenk
Elsevier’s recently launched citation metric CiteScore enables comprehensive, transparent, and current evaluation of a journal’s performance. For an editorial office, insight into a journal’s impact over time is of great value when making important decisions regarding the journal’s future. A 2016 update of CiteScore index values for Acta Dermatovenerologica Alpina, Pannonica et Adri- atica (Acta Dermatovenerol APA) showed a slight decrease in the CiteScore index value from 1.18 in 2015 to 0.96 in 2016...
September 2017: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28915573/lipid-catabolism-inhibition-sensitizes-prostate-cancer-cells-to-antiandrogen-blockade
#8
Thomas W Flaig, Maren Salzmann-Sullivan, Lih-Jen Su, Zhiyong Zhang, Molishree Joshi, Miguel A Gijón, Jihye Kim, John J Arcaroli, Adrie Van Bokhoven, M Scott Lucia, Francisco G La Rosa, Isabel R Schlaepfer
Prostate cancer (PCa) is the most common malignancy among Western men and the second leading-cause of cancer related deaths. For men who develop metastatic castration resistant PCa (mCRPC), survival is limited, making the identification of novel therapies for mCRPC critical. We have found that deficient lipid oxidation via carnitine palmitoyltransferase (CPT1) results in decreased growth and invasion, underscoring the role of lipid oxidation to fuel PCa growth. Using immunohistochemistry we have found that the CPT1A isoform is abundant in PCa compared to benign tissue (n=39, p<0...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28906284/effect-of-transfusion-on-mortality-and-other-adverse-events-among-critically-ill-septic-patients-an-observational-study-using-a-marginal-structural-cox-model
#9
Claire Dupuis, Maité Garrouste-Orgeas, Sébastien Bailly, Christophe Adrie, Dany Goldgran-Toledano, Elie Azoulay, Stéphane Ruckly, Guillaume Marcotte, Bertrand Souweine, Michael Darmon, Yves Cohen, Carole Schwebel, Guillaume Lacave, Lila Bouadma, Jean-Francois Timsit
OBJECTIVES: RBC transfusion is often required in patients with sepsis. However, adverse events have been associated with RBC transfusion, raising safety concerns. A randomized controlled trial validated the 7 g/dL threshold, but previously transfused patients were excluded. Cohort studies led to conflicting results and did not handle time-dependent covariates and history of treatment. Additional data are thus warranted to guide patient's management. DESIGN: To estimate the effect of one or more RBC within 1 day on three major outcomes (mortality, ICU-acquired infections, and severe hypoxemia) at day 30, we used marginal structural models...
December 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28888693/n-terminus-determines-activity-and-specificity-of-styrene-monooxygenase-reductases
#10
Thomas Heine, Anika Scholtissek, Adrie H Westphal, Willem J H van Berkel, Dirk Tischler
Styrene monooxygenases (SMOs) are two-enzyme systems that catalyze the enantioselective epoxidation of styrene to (S)-styrene oxide. The FADH2 co-substrate of the epoxidase component (StyA) is supplied by an NADH-dependent flavin reductase (StyB). The genome of Rhodococcus opacus 1CP encodes two SMO systems. One system, which we define as E1-type, displays homology to the SMO from Pseudomonas taiwanensis VLB120. The other system, originally reported as a fused system (RoStyA2B), is defined as E2-type. Here we found that E1-type RoStyB is inhibited by FMN, while RoStyA2B is known to be active with FMN...
September 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28884568/computational-study-of-low-interlayer-friction-in-tin-1cn-n-1-2-and-3-mxene
#11
Difan Zhang, Michael Ashton, Alireza Ostadhossein, Adri C T van Duin, Richard G Hennig, Susan B Sinnott
The friction of adjacent Tin+1Cn (n = 1, 2, and 3) MXene layers is investigated using density functional theory (DFT) calculations and classical molecular dynamics simulations with ReaxFF potentials. The calculations reveal the sliding pathways in all three MXene systems with low energy barriers. The friction coefficients for interlayer sliding are evaluated using static calculations. Both DFT and ReaxFF methods predict friction coefficients between 0.24 and 0.27 for normal loads less than 1.2 GPa. The effect of titanium (Ti) vacancies in sublayers and terminal oxygen (O) vacancies at surfaces on the interlayer friction is further investigated using the ReaxFF potential...
October 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28810729/thermal-stability-of-organic-monolayers-grafted-to-si-111-insights-from-reaxff-reactive-molecular-dynamics-simulations
#12
Federico A Soria, Weiwei Zhang, Adri C T van Duin, Eduardo M Patrito
We used the ReaxFF reactive molecular dynamics simulations to investigate the chemical mechanisms and kinetics of thermal decomposition processes of silicon surfaces grafted with different organic molecules via Si-C bonds at atomistic level. In this work, we considered the Si(111) surface grafted with n-alkyl (ethyl, propyl, pentyl, and decyl) layers in 50% coverage and, Si-CH3, Si-CCCH3 and Si-CHCHCH3 layers in full coverage. Si radicals primarily formed by the homolytic cleavage of Si-C bonds play a key role in the dehydrogenation processes that lead to the decomposition of the monolayers...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28794182/membrane-filtration-is-suitable-for-reliable-elimination-of-mycobacterium-tuberculosis-from-saliva-for-therapeutic-drug-monitoring
#13
LETTER
Simone H J van den Elsen, Tridia van der Laan, Onno W Akkerman, Adri G M van der Zanden, Jan-Willem C Alffenaar, Dick van Soolingen
No abstract text is available yet for this article.
November 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28791878/role-of-ergothioneine-in-microbial-physiology-and-pathogenesis
#14
Bridgette M Cumming, Krishna C Chinta, Vineel P Reddy, Adrie J C Steyn
SIGNIFICANCE: L-ergothioneine is synthesized in actinomycetes, cyanobacteria, methylobacteria, and some fungi. In contrast to other low-molecular-weight redox buffers, glutathione and mycothiol, ergothioneine is primarily present as a thione rather than a thiol at physiological pH, which makes it resistant to autoxidation. Ergothioneine regulates microbial physiology and enables the survival of microbes under stressful conditions encountered in their natural environments. In particular, ergothioneine enables pathogenic microbes, such as Mycobacterium tuberculosis (Mtb), to withstand hostile environments within the host to establish infection...
September 8, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28760899/susceptibility-of-mycobacterium-tuberculosis-cytochrome-bd-oxidase-mutants-to-compounds-targeting-the-terminal-respiratory-oxidase-cytochrome-c
#15
Atica Moosa, Dirk A Lamprecht, Kriti Arora, Clifton E Barry, Helena I M Boshoff, Thomas R Ioerger, Adrie J C Steyn, Valerie Mizrahi, Digby F Warner
We deleted subunits I (cydA) and II (cydB) of the Mycobacterium tuberculosis cytochrome bd menaquinol oxidase. The resulting ΔcydA and ΔcydAB mutants were hypersusceptible to compounds targeting the mycobacterial bc1 menaquinol-cytochrome c oxidoreductase and exhibited bioenergetic profiles indistinguishable from strains deficient in the ABC-type transporter, CydDC, predicted to be essential for cytochrome bd assembly. These results confirm CydAB and CydDC as potential targets for drugs aimed at inhibiting a terminal respiratory oxidase implicated in pathogenesis...
October 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28753915/colorful-packages-encapsulation-of-fluorescent-proteins-in-complex-coacervate-core-micelles
#16
Antsje Nolles, Adrie H Westphal, J Mieke Kleijn, Willem J H van Berkel, Jan Willem Borst
Encapsulation of proteins can be beneficial for food and biomedical applications. To study their biophysical properties in complex coacervate core micelles (C3Ms), we previously encapsulated enhanced green fluorescent protein (EGFP) and its monomeric variant, mEGFP, with the cationic-neutral diblock copolymer poly(2-methyl-vinyl-pyridinium)n-b-poly(ethylene-oxide)m (P2MVPn-b-PEOm) as enveloping material. C3Ms with high packaging densities of fluorescent proteins (FPs) were obtained, resulting in a restricted orientational freedom of the protein molecules, influencing their structural and spectral properties...
July 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28748346/trends-in-incidence-and-tumour-grade-in-screen-detected-ductal-carcinoma-in-situ-and-invasive-breast-cancer
#17
Jacky D Luiten, Adri C Voogd, Ernest J T Luiten, Lucien E M Duijm
PURPOSE: In a biennial screening mammography programme, we analysed the trends in incidence of screen-detected DCIS and invasive breast cancers in the era of screen-film mammography (SFM) screening, the period of the transition to full-field digital mammography (FFDM) screening and the period of FFDM screening. We also investigated a possible association between the incidence and grading of screen-detected DCIS and invasive breast cancer. METHODS: In the southern part of the Netherlands, FFDM screening gradually replaced SFM screening between May 2009 and April 2010...
July 26, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28708888/correction-mycobacterium-tuberculosis-arrests-host-cycle-at-the-g1-s-transition-to-establish-long-term-infection
#18
Bridgette M Cumming, Md Aejazur Rahman, Dirk A Lamprecht, Kyle H Rohde, Vikram Saini, John H Adamson, David G Russell, Adrie J C Steyn
[This corrects the article DOI: 10.1371/journal.ppat.1006389.].
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28707104/microbial-hydrocarbon-formation-from-biomass
#19
Adrie J J Straathof, Maria C Cuellar
Fossil carbon sources mainly contain hydrocarbons, and these are used on a huge scale as fuel and chemicals. Producing hydrocarbons from biomass instead is receiving increased attention. Achievable yields are modest because oxygen atoms need to be removed from biomass, keeping only the lighter carbon and hydrogen atoms. Microorganisms can perform the required conversions, potentially with high selectivity, using metabolic pathways that often end with decarboxylation. Metabolic and protein engineering are used successfully to achieve hydrocarbon production levels that are relevant in a biorefinery context...
July 14, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/28670303/3-hydroxybenzoate-6-hydroxylase-from-rhodococcus-jostii-rha1-contains-a-phosphatidylinositol-cofactor
#20
Stefania Montersino, Evelien Te Poele, Roberto Orru, Adrie H Westphal, Arjan Barendregt, Albert J R Heck, Robert van der Geize, Lubbert Dijkhuizen, Andrea Mattevi, Willem J H van Berkel
3-Hydroxybenzoate 6-hydroxylase (3HB6H, EC 1.13.14.26) is a FAD-dependent monooxygenase involved in the catabolism of aromatic compounds in soil microorganisms. 3HB6H is unique among flavoprotein hydroxylases in that it harbors a phospholipid ligand. The purified protein obtained from expressing the gene encoding 3HB6H from Rhodococcus jostii RHA1 in the host Escherichia coli contains a mixture of phosphatidylglycerol and phosphatidylethanolamine, which are the major constituents of E. coli's cytoplasmic membrane...
2017: Frontiers in Microbiology
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