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https://www.readbyqxmd.com/read/28325017/diffuse-reflectance-spectroscopy-can-differentiate-high-grade-and-low-grade-prostatic-carcinoma
#1
Priya N Werahera, Edward A Jasion, E David Crawford, M Scott Lucia, Adrie van Bokhoven, Holly T Sullivan, Fernando J Kim, Paul D Maroni, J David Port, John W Daily, Francisco G La Rosa
Prostate tumors are graded by the revised Gleason Score (GS) which is the sum of the two predominant Gleason grades present ranging from 6-10. GS 6 cancer exclusively with Gleason grade 3 is designated as low grade (LG) and correlates with better clinical prognosis for patients. GS >7 cancer with at least one of the Gleason grades 4 and 5 is designated as HG indicate worse prognosis for patients. Current transrectal ultrasound guided prostate biopsies often fail to correctly diagnose HG prostate cancer due to sampling errors...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28319661/atomistic-insights-into-nucleation-and-formation-of-hexagonal-boron-nitride-on-ni-from-first-principles-based-reactive-molecular-dynamics-simulations
#2
Song Liu, Adri C T van Duin, Diana M van Duin, Bin Liu, James H Edgar
Atomistic-scale insights into the growth of a continuous, atomically thin hexagonal boron nitride (hBN) lattice from elemental boron and nitrogen on Ni substrates were obtained from multi-scale modeling combining density functional theory (DFT) and reactive molecular dynamics (rMD). The quantum mechanical calculations focused on the adsorption and reaction energetics for the hBN building-block species, i.e., atomic B, N, BxNy (x, y = 1-2), on Ni(111) and Ni(211), and the diffusion pathways of elemental B and N on these slab model surfaces and in the sublayer...
March 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28303547/persistent-lymphopenia-is-a-risk-factor-for-icu-acquired-infections-and-for-death-in-icu-patients-with-sustained-hypotension-at-admission
#3
Christophe Adrie, Maxime Lugosi, Romain Sonneville, Bertrand Souweine, Stéphane Ruckly, Jean-Charles Cartier, Maité Garrouste-Orgeas, Carole Schwebel, Jean-François Timsit
BACKGROUND: Severely ill patients might develop an alteration of their immune system called post-aggressive immunosuppression. We sought to assess the risk of ICU-acquired infection and of mortality according to the absolute lymphocyte count at ICU admission and its changes over 3 days. METHODS: Adults in ICU for at least 3 days with a shock or persistent low blood pressure were extracted from a French ICU database and included. We evaluated the impact of the absolute lymphocyte count at baseline and its change at day 3 on the incidence of ICU-acquired infection and on the 28-day mortality rate...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28263569/inducible-site-specific-protein-labeling-by-tyrosine-oxidation-strain-promoted-4-2-cycloaddition
#4
Jorick J Bruins, Adrie H Westphal, Bauke Albada, Koen Wagner, Lina Bartels, Hergen Spits, Willem J H van Berkel, Floris L van Delft
Genetically encoded tyrosine (Y-tag) can be utilized as a latent anchor for inducible and site-selective conjugation. Upon oxidation of tyrosine with mushroom tyrosinase, strain-promoted cycloaddition (SPOCQ) of the resulting 1,2-quinone with various bicyclo[6.1.0]nonyne (BCN) derivatives led to efficient conjugation. The method was applied for fluorophore labeling of laminarinase A and for the site-specific preparation of an antibody-drug conjugate.
March 16, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28259165/validating-the-role-of-the-australian-national-university-alzheimer-s-disease-risk-index-anu-adri-and-a-genetic-risk-score-in-progression-to-cognitive-impairment-in-a-population-based-cohort-of-older-adults-followed-for-12-years
#5
Shea J Andrews, Ranmalee Eramudugolla, Jorge I Velez, Nicolas Cherbuin, Simon Easteal, Kaarin J Anstey
BACKGROUND: The number of people living with dementia is expected to exceed 130 million by 2050, which will have serious personal, social and economic implications. Employing successful intervention and treatment strategies focused on disease prevention is currently the only available approach that can have an impact on the projected rates of dementia, with risk assessment being a key component of population-based risk reduction for identification of at-risk individuals. We evaluated a risk index comprising lifestyle, medical and demographic factors (the Australian National University Alzheimer's Disease Risk Index [ANU-ADRI]), as well as a genetic risk score (GRS), for assessment of the risk of progression to mild cognitive impairment (MCI)...
March 4, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28258414/what-to-do-with-non-visualized-sentinel-nodes-a-dutch-nationwide-survey-study
#6
Nicole C Verheuvel, Adri C Voogd, Vivianne C G Tjan-Heijnen, Rudi M H Roumen
INTRODUCTION: International guidelines differ regarding their recommendations on axillary treatment of patients with non-visualized sentinel lymph nodes (non-vSLN). Therefore, we distributed a survey among Dutch oncological surgeons to determine their routine practice and opinion regarding axillary treatment in case of a non-vSLN, with the emphasis on whether these practices and opinions have changed since publication of the Z0011 trial. METHODS: A Dutch nationwide survey containing 10 questions regarding clinical routine during the sentinel node procedure and axillary treatment of non-vSLN patients was distributed among 510 oncological surgeons...
March 3, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28256799/prospects-and-challenges-for-the-recovery-of-2-butanol-produced-by-vacuum-fermentation-a-techno-economic-analysis
#7
Joana P C Pereira, Gustavo Lopez-Gomez, Noelia G Reyes, Luuk A M van der Wielen, Adrie J J Straathof
The conceptual design of a bio-based process for 2-butanol production is presented for the first time. Considering a hypothetical efficient producing strain, a vacuum fermentation is proposed to alleviate product toxicity, but the main challenge is the energy-efficient product recovery from the vapor. Three downstream scenarios were examined for this purpose: 1) multi-stage vapor recompression; 2) temperature swing adsorption; and 3) vapor absorption. The processes were simulated using Aspen Plus, considering a production capacity of 101 kton/yr...
March 3, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28256579/proline-dehydrogenase-from-thermus-thermophilus-does-not-discriminate-between-fad-and-fmn-as-cofactor
#8
Mieke M E Huijbers, Marta Martínez-Júlvez, Adrie H Westphal, Estela Delgado-Arciniega, Milagros Medina, Willem J H van Berkel
Flavoenzymes are versatile biocatalysts containing either FAD or FMN as cofactor. FAD often binds to a Rossmann fold, while FMN prefers a TIM-barrel or flavodoxin-like fold. Proline dehydrogenase is denoted as an exception: it possesses a TIM barrel-like fold while binding FAD. Using a riboflavin auxotrophic Escherichia coli strain and maltose-binding protein as solubility tag, we produced the apoprotein of Thermus thermophilus ProDH (MBP-TtProDH). Remarkably, reconstitution with FAD or FMN revealed that MBP-TtProDH has no preference for either of the two prosthetic groups...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28244208/differences-in-care-burden-of-patients-undergoing-dialysis-in-different-centres-in-the-netherlands
#9
Ria de Kleijn, Carin Uyl-de Groot, Chris Hagen, Adry Diepenbroek, Pieternel Pasker-de Jong, Piet Ter Wee
BACKGROUND: A classification model was developed to simplify planning of personnel at dialysis centres. This model predicted the care burden based on dialysis characteristics. However, patient characteristics and different dialysis centre categories might also influence the amount of care time required. OBJECTIVE: To determine if there is a difference in care burden between different categories of dialysis centres and if specific patient characteristics predict nursing time needed for patient treatment...
February 27, 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/28227670/diffuse-reflectance-spectroscopy-can-differentiate-high-grade-and-low-grade-prostatic-carcinoma
#10
Priya N Werahera, Edward A Jasion, E David Crawford, M Scott Lucia, Adrie van Bokhoven, Holly T Sullivan, Fernando J Kim, Paul D Maroni, J David Port, John W Daily, Francisco G La Rosa, Priya N Werahera, Edward A Jasion, E David Crawford, M Scott Lucia, Adrie van Bokhoven, Holly T Sullivan, Fernando J Kim, Paul D Maroni, J David Port, John W Daily, Francisco G La Rosa, John W Daily, Adrie Van Bokhoven, E David Crawford, J David Port, Priya N Werahera, M Scott Lucia, Holly T Sullivan, Paul D Maroni, Edward A Jasion, Francisco G La Rosa, Fernando J Kim
Prostate tumors are graded by the revised Gleason Score (GS) which is the sum of the two predominant Gleason grades present ranging from 6-10. GS 6 cancer exclusively with Gleason grade 3 is designated as low grade (LG) and correlates with better clinical prognosis for patients. GS >7 cancer with at least one of the Gleason grades 4 and 5 is designated as HG indicate worse prognosis for patients. Current transrectal ultrasound guided prostate biopsies often fail to correctly diagnose HG prostate cancer due to sampling errors...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222952/esters-production-via-carboxylates-from-anaerobic-paper-mill-wastewater-treatment
#11
Carlos I Cabrera-Rodríguez, Mónica Moreno-González, Florence A de Weerd, Vidhvath Viswanathan, Luuk A M van der Wielen, Adrie J J Straathof
This paper describes a new option for integrated recovery and esterification of carboxylates produced by anaerobic digestion at a pH above the pKa. The carboxylates (acetate, propionate, butyrate, valerate and lactate) are recovered using a strong anion exchange resin in the bicarbonate form, and the resin is regenerated using a CO2-expanded alcohol technique, which allows for low chemicals consumption and direct esterification. Paper mill wastewater was used to study the effect of pH and the presence of other inorganic anions and cations on the adsorption and desorption with CO2-expanded methanol...
February 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28216997/genetic-mapping-and-qtl-analysis-of-botrytis-resistance-in-gerbera-hybrida
#12
Yiqian Fu, Alex van Silfhout, Arwa Shahin, Ronny Egberts, Martin Beers, Ans van der Velde, Adrie van Houten, Jaap M van Tuyl, Richard G F Visser, Paul Arens
Gerbera hybrida is an economically important cut flower. In the production and transportation of gerbera with unavoidable periods of high relative humidity, grey mould occurs and results in losses in quality and quantity of flowers. Considering the limitations of chemical use in greenhouses and the impossibility to use these chemicals in auction or after sale, breeding for resistant gerbera cultivars is considered as the best practical approach. In this study, we developed two segregating F1 populations (called S and F)...
2017: Molecular Breeding: New Strategies in Plant Improvement
https://www.readbyqxmd.com/read/28213306/phosphorous-extractability-and-ryegrass-availability-from-bio-waste-composts-in-a-calcareous-soil
#13
Marco Grigatti, Elisa Boanini, Silvia Mancarella, Andrea Simoni, Massimo Centemero, Adrie H M Veeken
In this work four stable bio-waste composts (C1, C2, C3, C4) were selected on the basis of their increasing water soluble P (H2O-P). The P speciation was assessed via sequential chemical extraction (SCE) on the same products. Moreover, the plant-available P was assessed via apparent recovery fraction approach (ARF) in a pot test on ryegrass over 21 weeks at 15 mg P kg(-)(1) of soil. An inorganic P source (P-chem) was added as a reference at the same P rate in addition to a non-fertilized control (Control)...
May 2017: Chemosphere
https://www.readbyqxmd.com/read/28142297/pannexin1-single-nucleotide-polymorphism-and-platelet-reactivity-in-a-cohort-of-cardiovascular-patients
#14
Florian B Stierlin, Filippo Molica, Jean-Luc Reny, Brenda R Kwak, Pierre Fontana
Pannexin1 (Panx1), a membrane channel-forming protein permitting the passage of small-sized molecules, such as ATP, is expressed in human platelets. Recently, we showed that inhibiting Panx1 affects collagen-induced platelet aggregation but not aggregation triggered by other agonists. We also found that a single nucleotide polymorphism (SNP; rs1138800) in the Panx1 gene encoded for a gain-of-function channel (Panx1-400C) and was associated with enhanced collagen-induced platelet reactivity. Here, we assessed the association of this SNP with platelet reactivity in a cohort of 758 stable cardiovascular patients from the ADRIE study treated with aspirin and/or clopidogrel...
December 2017: Cell Communication & Adhesion
https://www.readbyqxmd.com/read/28140413/reaxff-based-molecular-dynamics-simulations-of-ignition-front-propagation-in-hydrocarbon-oxygen-mixtures-under-high-temperature-and-pressure-conditions
#15
Chowdhury Ashraf, Abhishek Jain, Yuan Xuan, Adri C T van Duin
In this paper, we present the first atomistic-scale based method for calculating ignition front propagation speed and hypothesize that this quantity is related to laminar flame speed. This method is based on atomistic-level molecular dynamics (MD) simulations with the ReaxFF reactive force field. Results reported in this study are for supercritical (P = 55 MPa and Tu = 1800 K) combustion of hydrocarbons as elevated pressure and temperature are required to accelerate the dynamics for reactive MD simulations...
January 31, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28132393/breast-mri-increases-the-number-of-mastectomies-for-ductal-cancers-but-decreases-them-for-lobular-cancers
#16
Marc B I Lobbes, Ingeborg J H Vriens, Annelotte C M van Bommel, Grard A P Nieuwenhuijzen, Marjolein L Smidt, Liesbeth J Boersma, Thijs van Dalen, Carolien Smorenburg, Henk Struikmans, Sabine Siesling, Adri C Voogd, Vivianne C G Tjan-Heijnen
PURPOSE: In this retrospective population-based cohort study, we analyzed breast MRI use and its impact on type of surgery, surgical margin involvement, and the diagnosis of contralateral breast cancer. METHODS: All Dutch patients with cT1-4N0-3M0 breast cancer diagnosed in 2011-2013 and treated with primary surgery were eligible for inclusion. Using multivariable analyses, we analyzed in different categories whether MRI use was related to surgery type, margin involvement, and diagnosis of contralateral breast cancer (CBC)...
April 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28121480/antihyperglycemic-effect-of-quercetin-in-ovariectomized-rats-treated-with-tamoxifen
#17
Fernanda Coleraus Silva, Isabella Calvo Bramatti, Adrieli Gorlin Toledo, Fernando Marques Salles, Ana Maria Itinose, Carla Brugin Marek
Tamoxifen is effective in breast cancer therapy in postmenopausal women; however, it causes adverse effects that alter the glycolytic pathway and induce hyperglycemia. Quercetin, a flavonoid with antioxidant potential, inhibits butyrylcholinesterase (BuChE), which is positively associated with hyperglycemia. Therefore, this study investigated the effect of quercetin on tamoxifen-induced hyperglycemia, using BuChE activity as a bioindicator in adult ovariectomized Wistar rats. The ovariectomized rats were treated orally for 14 days with different concentrations of quercetin (2...
March 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28120368/growth-of-stable-surface-oxides-on-pt-111-at-near-ambient-pressures
#18
Donato Fantauzzi, Sandra Krick Calderón, Jonathan E Mueller, Mathias Grabau, Christian Papp, Hans-Peter Steinrück, Thomas P Senftle, Adri C T van Duin, Timo Jacob
Detailed knowledge of the structure and degree of oxidation of platinum surfaces under operando conditions is essential for understanding catalytic performance. However, experimental investigations of platinum surface oxides have been hampered by technical limitations, preventing in situ investigations at relevant pressures. As a result, the time-dependent evolution of oxide formation has only received superficial treatment. In addition, the amorphous structures of many surface oxides have hindered realistic theoretical studies...
March 1, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28103669/reaxff-reactive-force-field-study-of-molybdenum-disulfide-mos2
#19
Alireza Ostadhossein, Ali Rahnamoun, Yuanxi Wang, Peng Zhao, Sulin Zhang, Vincent H Crespi, Adri C T van Duin
Two-dimensional layers of molybdenum disulfide, MoS2, have been recognized as promising materials for nanoelectronics due to their exceptional electronic and optical properties. Here we develop a new ReaxFF reactive potential that can accurately describe the thermodynamic and structural properties of MoS2 sheets, guided by extensive density functional theory simulations. This potential is then applied to the formation energies of five different types of vacancies, various vacancy migration barriers, and the transition barrier between the semiconducting 2H and metallic 1T phases...
January 23, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28099586/serotoninergic-modulation-of-basal-cardiovascular-responses-and-responses-induced-by-isotonic-extracellular-volume-expansion-in-rats
#20
Isadora Ferraz Semionatto, Adrieli Oliveira Raminelli, Angelica Cristina Alves, Caroline Santos Capitelli, Rosangela Soares Chriguer
Background: Isotonic blood volume expansion (BVE) induced alterations of sympathetic and parasympathetic activity in the heart and blood vessels, which can be modulated by serotonergic pathways. Objective: To evaluate the effect of saline or serotonergic agonist (DOI) administration in the hypothalamic paraventricular nucleus (PVN) on cardiovascular responses after BVE. Methods: We recorded pulsatile blood pressure through the femoral artery to obtain the mean arterial pressure (MAP), systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR) and the sympathetic-vagal ratio (LF/HF) of Wistar rats before and after they received bilateral microinjections of saline or DOI into the PVN, followed by BVE...
January 16, 2017: Arquivos Brasileiros de Cardiologia
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