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https://www.readbyqxmd.com/read/29471168/developmental-toxicity-of-penconazole-in-zebrfish-danio-rerio-embryos
#1
Feyza Icoglu Aksakal, Abdulkadir Ciltas
Penconazole is a widely used fungicide that is toxic to a variety of organisms including fish. In the present study, we investigated the developmental toxicity of penconazole on zebrafish embryos by exposing to different concentrations of penconazole (0.8, 1.6 and 2.4 mg/L) from 4-h post-fertilization (hpf). Hatching, survival, and heart rates, body length, malformation and expression of several genes were detected. The results showed that penconazole exposure induced developmental toxicity, including delayed hatching, reduced survival, and heart rate...
February 17, 2018: Chemosphere
https://www.readbyqxmd.com/read/29471159/operation-versus-watchful-waiting-in-asymptomatic-or-minimally-symptomatic-inguinal-hernias-the-meta-analysis-results-of-randomized-controlled-trials
#2
REVIEW
Wenbin Gong, Junsheng Li
INTRODUCTION: The aim of this article was to compare and analyze the outcomes of surgical repair and watchful waiting (WW) in the treatment of asymptomatic or minimally symptomatic inguinal hernias. METHODS: A systematic literature review was undertaken to identify studies that compare surgical repair and watchful waiting in asymptomatic or minimally symptomatic inguinal hernias. And all related data matching our standards were abstracted for Meta-analysis with RevMan 5...
February 19, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29471104/cellular-senescence-as-a-therapeutic-target-to-improve-renal-transplantation-outcome
#3
REVIEW
Hester van Willigenburg, Peter L J de Keizer, Ron W F de Bruin
Kidney transplants from aged donors are more vulnerable to ischemic injury, suffer more from delayed graft function and have a lower graft survival compared to kidneys from younger donors. On a cellular level, aging results in an increase in cells that are in a permanent cell cycle arrest, termed senescence, which secrete a range of pro-inflammatory cytokines and growth factors. Consequently, these senescent cells negatively influence the local milieu by causing inflammaging, and by reducing the regenerative capacity of the kidney...
February 19, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29471078/development-of-controlled-drug-delivery-systems-for-bone-fracture-targeted-therapeutic-delivery-a-review
#4
REVIEW
Yuchen Wang, Maureen R Newman, Danielle S W Benoit
Impaired fracture healing is a major clinical problem that can lead to patient disability, prolonged hospitalization, and significant financial burden. Although the majority of fractures heal using standard clinical practices, approximately 10% suffer from delayed unions or non-unions. A wide range of factors contribute to the risk for nonunions including internal factors, such as patient age, gender, and comorbidities, and external factors, such as the location and extent of injury. Current clinical approaches to treat nonunions include bone grafts and low-intensity pulsed ultrasound (LIPUS), which realizes clinical success only to select patients due to limitations including donor morbidities (grafts) and necessity of fracture reduction (LIPUS), respectively...
February 19, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29471062/constitutive-stimulatory-g-protein-activity-in-limb-mesenchyme-impairs-bone-growth
#5
Anara Karaca, Vijayram Reddy Malladi, Yan Zu, Olta Tafaj, Elena Paltrinieri, Joy Y Wu, Qing He, Murat Bastepe
GNAS mutations leading to constitutively active stimulatory G protein alpha-subunit (Gsα) cause different tumors, fibrous dysplasia of bone, and McCune-Albright syndrome, which are typically not associated with short stature. Enhanced signaling of the parathyroid hormone/parathyroid hormone-related peptide receptor, which couples to multiple G proteins including Gsα, leads to short bones with delayed endochondral ossification. It has remained unknown whether constitutive Gsα activity also impairs bone growth...
February 19, 2018: Bone
https://www.readbyqxmd.com/read/29471004/prostate-cancer-chemoprevention-by-natural-agents-clinical-evidence-and-potential-implications
#6
Gagan Chhabra, Chandra K Singh, Mary Ann Ndiaye, Samantha Fedorowicz, Arielle Molot, Nihal Ahmad
Prostate cancer (PCa) is the most common non-skin cancer and the second leading cause of cancer-related deaths in American men. Due to its long latency period, PCa is considered as an ideal cancer type for chemopreventive interventions. Chemopreventive agents include various natural or synthetic agents that prevent or delay cancer development, progression and/or recurrence. Pre-clinical studies suggest that many natural products and dietary agents have chemopreventive properties. However, a limited number of these agents have been tested in clinical trials, with varying success...
February 19, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29470545/private-healthcare-provider-experiences-with-social-health-insurance-schemes-findings-from-a-qualitative-study-in-ghana-and-kenya
#7
Maia Sieverding, Cynthia Onyango, Lauren Suchman
BACKGROUND: Incorporating private healthcare providers into social health insurance schemes is an important means towards achieving universal health coverage in low and middle income countries. However, little research has been conducted about why private providers choose to participate in social health insurance systems in such contexts, or their experiences with these systems. We explored private providers' perceptions of and experiences with participation in two different social health insurance schemes in Sub-Saharan Africa-the National Health Insurance Scheme (NHIS) in Ghana and the National Hospital Insurance Fund (NHIF) in Kenya...
2018: PloS One
https://www.readbyqxmd.com/read/29470266/posterior-reversible-encephalopathy-syndrome
#8
Courtney Stanley Sundin, Michelle Laurane Johnson
Posterior reversible encephalopathy syndrome (PRES) is a newly defined syndrome; therefore, this transient clinical condition is not well known and probably underdiagnosed. It develops quickly with symptoms that are usually indistinguishable from eclampsia. Nurses need to be knowledgeable and aware of identifying symptoms and appropriate treatment. The condition is thought to share pathophysiology with eclampsia, and it is suggested that endothelial dysfunction combined with hypertension causes disruption in the blood brain barrier resulting in cerebral edema...
March 2018: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/29470183/the-central-effects-of-androgenic-anabolic-steroid-use
#9
Marek Mędraś, Anna Brona, Paweł Jóźków
: Millions of men use androgenic-anabolic steroids (AAS) to stimulate muscle growth and improve physical appearance. Although 1 out of 3 people who uses androgenic-anabolic steroids develops a steroid use disorder, the effects of the drugs on the central nervous system and the psyche are still not well understood. Although most addictive substances improve mood immediately after administration, AAS exert less pronounced euphoric effects. Instead, they are primarily taken for the delayed gratification of increased muscle mass...
February 21, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29470117/adaptive-behavior-of-sheltered-homeless-children-in-the-french-enfams-survey
#10
Stéphane Darbeda, Bruno Falissard, Massimiliano Orri, Caroline Barry, Maria Melchior, Pierre Chauvin, Stéphanie Vandentorren
OBJECTIVES: To describe the adaptive behaviors in a large sample of homeless children and identify factors associated with developmental delay. METHODS: Data were from a cross-sectional survey of 557 children younger than 6 years randomly sampled among homeless sheltered families in the Paris, France, region (January-May 2013). An interviewer and a psychologist conducted face-to-face interviews to collect information on sociodemographic and health characteristics...
February 22, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29469783/delayed-presentation-of-toxic-epidermal-necrolysis-like-cutaneous-acute-graft-versus-host-disease-in-the-setting-of-recent-immunosuppressant-discontinuation
#11
Parul K Kathuria Goyal, Shuai Xu, Jennifer Choi
Acute graft-versus-host disease (GvHD) is a process that classically has been defined as occurring less than 100 days after stem cell transplant. When Stage IV cutaneous acute GvHD occurs outside this window, it can be difficult to distinguish clinically from toxic epidermal necrolysis (TEN). A 50-year-old man with diffuse large B-cell lymphoma who had undergone an allogeneic stem cell transplant 20 months previously was admitted for neutropenic septic shock. He developed a slowly progressing macular/papular eruption with multiple tender bullae found to be consistent with TEN-like Stage IV cutaneous acute GvHD on biopsy...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469698/acquired-bullous-acrodermatitis-enteropathica-as-a-histologic-mimic-of-pemphigus-foliaceus-in-a-patient-on-parenteral-nutrition
#12
Davina Wu, Maxwell A Fung, Maija Kiuru, Victoria R Sharon
Acquired zinc deficiency can develop as a consequence of poor nutritional intake or from dependence on total parenteral nutrition. Acquired zinc deficiency dermatitis classically manifests with erosions and scaly plaques in a periorificial and acral distribution. We present a case of a woman on parenteral nutrition who presented with bullous acrodermatitis mimicking pemphigus foliaceus histopathologically. This case highlights clinical and histopathologic variants of zinc deficiency that may lead to a delay in diagnosis...
July 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29468257/aurora-kinase-b-regulates-axonal-outgrowth-and-regeneration-in-the-spinal-motor-neurons-of-developing-zebrafish
#13
Serene S L Gwee, Rowan A W Radford, Sharron Chow, Monisha D Syal, Marco Morsch, Isabel Formella, Albert Lee, Emily K Don, Andrew P Badrock, Nicholas J Cole, Adrian K West, Steve N S Cheung, Roger S Chung
Aurora kinase B (AurkB) is a serine/threonine protein kinase with a well-characterised role in orchestrating cell division and cytokinesis, and is prominently expressed in healthy proliferating and cancerous cells. However, the role of AurkB in differentiated and non-dividing cells has not been extensively explored. Previously, we have described a significant upregulation of AurkB expression in cultured cortical neurons following an experimental axonal transection. This is somewhat surprising, as AurkB expression is generally associated only with dividing cells Frangini et al...
February 21, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29467993/pediatric-renal-transplantation-in-oman-a-single-center-experience
#14
Mohamed S Al Riyami, Sulaiman Al Saidi, Badria Al Ghaithi, Anisa Al Maskari, Sadiq Lala, Nabil Mohsin, Lekha Hirshikesan, Naifain Al Kalbani
Objectives: This study sought to report 22 years experience in pediatric kidney transplantation in Oman. Methods: Electronic charts of all Omani children below 13 years of age who received a kidney transplant from January 1994 to December 2015 were reviewed. Data collected included patient demographics, etiology of end-stage kidney disease, modality and duration of dialysis, donor type, complication of kidney transplantation (including surgical complications, infections, graft rejection) graft and patient survival, and duration of follow-up...
January 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29467918/preclinical-assessment-of-galunisertib-ly2157299-monohydrate-a-first-in-class-transforming-growth-factor-%C3%AE-receptor-type-i-inhibitor
#15
Jonathan M Yingling, William T McMillen, Lei Yan, Huocong Huang, J Scott Sawyer, Jeremy Graff, David K Clawson, Karen S Britt, Bryan D Anderson, Douglas W Beight, Durisala Desaiah, Michael M Lahn, Karim A Benhadji, Maria J Lallena, Rikke B Holmgaard, Xiaohong Xu, Faming Zhang, Jason R Manro, Philip W Iversen, Chandrasekar V Iyer, Rolf A Brekken, Michael D Kalos, Kyla E Driscoll
Transforming growth factor-β (TGFβ) is an important driver of tumor growth via intrinsic and extrinsic mechanisms, and is therefore an attractive target for developing cancer therapeutics. Using preclinical models, we characterized the anti-tumor activity of a small molecule inhibitor of TGFβ receptor I (TGFβRI), galunisertib (LY2157299 monohydrate). Galunisertib demonstrated potent and selective inhibition of TGFβRI with corresponding inhibition of downstream signaling via inhibition of SMAD phosphorylation (pSMAD)...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467774/genome-based-prediction-of-time-to-curd-induction-in-cauliflower
#16
Arne Rosen, Yaser Hasan, William Briggs, Ralf Uptmoor
The development of cauliflower ( Brassica oleracea var. botrytis ) is highly dependent on temperature due to vernalization requirements, which often causes delay and unevenness in maturity during months with warm temperatures. Integrating quantitative genetic analyses with phenology modeling was suggested to accelerate breeding strategies toward wide-adaptation cauliflower. The present study aims at establishing a genome-based model simulating the development of doubled haploid (DH) cauliflower lines to predict time to curd induction of DH lines not used for model parameterization and test hybrids derived from the bi-parental cross...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29467751/photodynamic-vaccination-of-balb-c-mice-for-prophylaxis-of-cutaneous-leishmaniasis-caused-by-leishmania-amazonensis
#17
Sayonara M Viana, Fabiana S Celes, Laura Ramirez, Bala Kolli, Dennis K P Ng, Kwang P Chang, Camila I de Oliveira
Background: Photosensitizers (PS), like porphyrins and phthalocyanines (PC) are excitable by light to generate cytotoxic singlet oxygen and other reactive oxygen species in the presence of atmospheric O2 . Photodynamic inactivation of Leishmania by this means renders them non-viable, but preserves their effective use as vaccines. Leishmania can be photo-inactivated after PS-sensitization by loading via their endocytic uptake of PC or endogenous induction of transgenic mutants with delta-aminolevulinate (ALA) to accumulate cytosolic uroporphyrin I (URO)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29467709/delayed-latency-of-postural-muscles-of-individuals-with-intellectual-disabilities
#18
J Walter Tolentino-Castro, Andreas Mühlbeier, Luis Mochizuki, Heiko Wagner
Individuals with intellectual disabilities (ID) (50 < IQ < 79) show impaired motor and postural control, these impairments are highly related to falls and injuries. Recent studies demonstrated these impairments are related with fine and gross motor development, which are more strongly associated with cognition, and consequently language for individuals with ID than for without ID. Despite these studies, little is known about the structure and functioning of this population's spinal cord, which is highly involved in postural control...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29467473/embryonic-lethality-in-mice-lacking-trim59-due-to-impaired-gastrulation-development
#19
Xiaomin Su, Chenglei Wu, Xiaoying Ye, Ming Zeng, Zhujun Zhang, Yongzhe Che, Yuan Zhang, Lin Liu, Yushuang Lin, Rongcun Yang
TRIM family members have been implicated in a variety of biological processes such as differentiation and development. We here found that Trim59 plays a critical role in early embryo development from blastocyst stage to gastrula. There existed delayed development and empty yolk sacs from embryonic day (E) 8.5 in Trim59-/- embryos. No viable Trim59-/- embryos were observed beyond E9.5. Trim59 deficiency affected primary germ layer formation at the beginning of gastrulation. At E6.5 and E7.5, the expression of primary germ layer formation-associated genes including Brachyury, lefty2, Cer1, Otx2, Wnt3, and BMP4 was reduced in Trim59-/- embryos...
February 21, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29467242/prothoracicotropic-hormone-modulates-environmental-adaptive-plasticity-through-the-control-of-developmental-timing
#20
MaryJane Shimell, Xueyang Pan, Francisco A Martin, Arpan C Ghosh, Pierre Leopold, Michael B O'Connor, Nuria M Romero
Adult size and fitness are controlled by a combination of genetics and environmental cues. In Drosophila , growth is confined to the larval phase and final body size is impacted by the duration of this phase, which is under neuroendocrine control. The neuropeptide prothoracicotropic hormone (PTTH) has been proposed to play a central role in controlling the length of the larval phase through regulation of ecdysone production, a steroid hormone that initiates larval molting and metamorphosis. Here, we test this issue by examining the consequences of null mutations in the ptth gene on Drosophila development...
February 21, 2018: Development
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