keyword
https://read.qxmd.com/read/38535864/strategies-for-transboundary-swine-disease-management-in-asian-islands-foot-and-mouth-disease-classical-swine-fever-and-african-swine-fever-in-taiwan-japan-and-the-philippines
#1
REVIEW
Chia-Hui Hsu, Chia-Yi Chang, Satoshi Otake, Thomas W Molitor, Andres Perez
Swine transboundary diseases pose significant challenges in East and Southeast Asia, affecting Taiwan, Japan, and the Philippines. This review delves into strategies employed by these islands over the past two decades to prevent or manage foot and mouth disease (FMD), classical swine fever (CSF), and African swine fever (ASF) in domestic pigs and wild boars. Despite socio-economic differences, these islands share geographical and climatic commonalities, influencing their thriving swine industries. Focusing on FMD eradication, this study unveils Taiwan's success through mass vaccination, Japan's post-eradication surveillance, and the Philippines' zoning strategy...
March 15, 2024: Veterinary Sciences
https://read.qxmd.com/read/38533953/polygenic-scores-and-preclinical-cardiovascular-disease-in-individuals-with-hiv-insights-from-the-reprieve-trial
#2
JOURNAL ARTICLE
Roger S Zou, Yunfeng Ruan, Buu Truong, Romit Bhattacharya, Michael T Lu, Júlia Karády, Rachel Bernardo, Phoebe Finneran, Whitney Hornsby, Kathleen V Fitch, Heather J Ribaudo, Markella V Zanni, Pamela S Douglas, Steven K Grinspoon, Aniruddh P Patel, Pradeep Natarajan
BACKGROUND: Coronary artery disease (CAD) is a leading cause of death among the 38.4 million people with HIV globally. The extent to which cardiovascular polygenic risk scores (PRSs) derived in non-HIV populations generalize to people with HIV is not well understood. METHODS AND RESULTS: PRSs for CAD (GPSMult ) and lipid traits were calculated in a global cohort of people with HIV treated with antiretroviral therapy with low-to-moderate atherosclerotic cardiovascular disease risk enrolled in REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV)...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38532377/the-need-for-and-acceptability-of-a-curriculum-to-train-nursing-and-medical-students-in-the-sexual-healthcare-of-clients-with-female-genital-mutilation-cutting-in-tanzania
#3
JOURNAL ARTICLE
Dorkasi L Mwakawanga, Agnes F Massae, Nidhi Kohli, Gift Gadiel Lukumay, Corissa T Rohloff, Stella Emmanuel Mushy, Lucy R Mgopa, Dickson Ally Mkoka, Ever Mkonyi, Maria Trent, Michael W Ross, B R Simon Rosser, Jennifer Connor
BACKGROUND: Female genital mutilation/cutting (FGM/C) is tied to one of the most conservative cultures in the Mediterranean and Sub-Saharan Africa. More than 200 million girls and women in 30 African, Asian and the middle Eastern countries have undergone FGM/C. However, healthcare professionals are not adequately trained to prevent and manage FGM/C-related complications including sexual health problems. This study aimed to assess the need and acceptability of a curriculum to train nursing and medical students in the sexual healthcare of clients with FGM/C in Tanzania...
March 26, 2024: BMC Women's Health
https://read.qxmd.com/read/38531057/impact-of-race-and-social-determinants-of-health-on-outcomes-in-patients-with-aggressive-b-cell-nhl-treated-with-car-t
#4
JOURNAL ARTICLE
Reem Karmali, Rushad Machhi, Narendranath Epperla, Geoffrey Shouse, Jason T Romancik, Tamara K Moyo, Vaishalee P Kenkre, Thomas A Ollila, Lindsey A Fitzgerald, Brian T Hess, Kevin A David, Ishan Roy, Joanna C Zurko, Sayan Mullick Chowdhury, Kaitlin Annunzio, Robert Ferdman, Rahul S Bhansali, Elyse I Harris, Jieqi Liu, Imran A Nizamuddin, Shuo Ma, Jonathan Moreira, Jane N Winter, Barbara Pro, Deborah M Stephens, Alexey V Danilov, Nirav N Shah, Jonathon B Cohen, Stefan K Barta, Pallawi Torka, Leo I Gordon
Healthcare disparities driven by multiple social, economic, and/or environmental factors lead to inequalities in health outcomes. CAR-T cell immunotherapy is an effective therapy for relapsed/refractory B-cell non-Hodgkin lymphoma (r/r B-NHL). However, data are limited on the impact of the convergence of race and social determinants of health on outcomes for patients treated with CAR-T therapy. We examined the impact of interactions between race and insurance type on health care utilization and outcomes in patients treated with CAR-T for aggressive B-NHL...
March 26, 2024: Blood Advances
https://read.qxmd.com/read/38530702/clinical-trial-inclusion-and-impact-on-early-adoption-of-medical-innovation-in%C3%A2-diverse-populations
#5
JOURNAL ARTICLE
Philip B Adamson, Melvin Echols, Ersilia M DeFilippis, Alanna A Morris, Mosi Bennett, William T Abraham, JoAnn Lindenfeld, John R Teerlink, Christopher M O'Connor, Allison T Connolly, Huanan Li, Mona Fiuzat, Muthiah Vaduganathan, Orly Vardeny, Wayne Batchelor, Kelly C McCants
BACKGROUND: Inadequate inclusion in clinical trial enrollment may contribute to health inequities by evaluating interventions in cohorts that do not fully represent target populations. OBJECTIVES: The aim of this study was to determine if characteristics of patients with heart failure (HF) enrolled in a pivotal trial are associated with who receives an intervention after approval. METHODS: Demographics from 2,017,107 Medicare patients hospitalized for HF were compared with those of the first 10,631 Medicare beneficiaries who received implantable pulmonary artery pressure sensors...
March 21, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38527805/science-education-for-the-youth-sefty-a-neuroscience-outreach-program-for-high-school-students-in-southern-nevada-during-the-covid-19-pandemic
#6
JOURNAL ARTICLE
Nabih Ghani, Hayley Baker, Audrey Huntsinger, Tiffany Chen, Tiffany D Familara, Jose Yani Itorralba, Fritz Vanderford, Xiaowei Zhuang, Ching-Lan Chang, Van Vo, Edwin C Oh
Laboratory outreach programs for K-12 students in the United States from 2020-2022 were suspended or delayed due to COVID-19 restrictions. While Southern Nevada also observed similar closures for onsite programs, we and others hypothesized that in-person laboratory activities could be prioritized after increasing vaccine doses were available to the public and masking was encouraged. Here, we describe how the Laboratory of Neurogenetics and Precision Medicine at the University of Nevada Las Vegas (UNLV) collaborated with administrators from a local school district to conduct training activities for high school students during the COVID-19 pandemic...
March 25, 2024: ENeuro
https://read.qxmd.com/read/38525631/the-characteristics-of-dermatology-inpatients-seen-at-the-quaternary-inkosi-albert-luthuli-central-hospital-in-durban-south-africa-over-a-5-year-period-2015-2020
#7
JOURNAL ARTICLE
L Mthembu, J T Masuka, K Duze, A Mosam
BACKGROUND: In recent years, dermatology has been offered as an outpatient service, with decreasing inpatient dermatology admissions. However, dermatology consultation services have remained active, offering care to patients admitted for non-cutaneous indications by other specialties. OBJECTIVES: To describe the clinical spectrum and characteristics of inpatient dermatology diseases managed at a quaternary South African (SA) hospital. METHODS: We retrospectively reviewed and analysed electronic records of all dermatology inpatients managed by dermatologists from 2015 to 2020 at Inkosi Albert Luthuli Central Hospital (IALCH) in Durban, South Africa...
December 31, 2023: South African Medical Journal
https://read.qxmd.com/read/38523305/clinical-spectrum-of-transthyretin-amyloidogenic-mutations-among-diverse-population-origins
#8
JOURNAL ARTICLE
Antonella De Lillo, Gita A Pathak, Aislinn Low, Flavio De Angelis, Sarah Abou Alaiwi, Edward J Miller, Maria Fuciarelli, Renato Polimanti
PURPOSE: Coding mutations in the Transthyretin (TTR) gene cause a hereditary form of amyloidosis characterized by a complex genotype-phenotype correlation with limited information regarding differences among worldwide populations. METHODS: We compared 676 diverse individuals carrying TTR amyloidogenic mutations (rs138065384, Phe44Leu; rs730881165, Ala81Thr; rs121918074, His90Asn; rs76992529, Val122Ile) to 12,430 non-carriers matched by age, sex, and genetically-inferred ancestry to assess their clinical presentations across 1,693 outcomes derived from electronic health records in UK biobank...
March 25, 2024: Human Genomics
https://read.qxmd.com/read/38523016/donor-recipient-race-ethnicity-concordance-and-patient-survival-after-liver-transplantation
#9
JOURNAL ARTICLE
Makenna Laffey, Eishan Ashwat, Hao Lui, Xingyu Zhang, Christof Kaltenmeier, Godwin Packiaraj, Andrew Crane, Sarmad Alshamery, Vikraman Gunabushanam, Armando Ganoza, Stalin Dharmayan, Colin A Powers, Naudia Jonassaint, Michele Molinari
INTRODUCTION: We assessed the association between patient survival after liver transplantation (LT) and donor-recipient race-ethnicity (R/E) concordance. METHODS: The Scientific Registry of Transplant Recipients (SRTR) was retrospectively analyzed using data collected between 2002 and 2019. Only adults without history of prior organ transplant and recipients of LT alone were included. The primary outcome was patient survival. Donors and recipients were categorized into five R/E groups: White/Caucasian, African American/Black, Hispanic/Latino, Asian, and Others...
March 11, 2024: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/38520313/impact-of-il-10-gene-promoter-polymorphisms-on-treatment-response-in-hcv-patients-a-systematic-review-a-meta-analysis-and-a-meta-regression
#10
JOURNAL ARTICLE
Tarak Dhaouadi, Awatef Riahi, Taïeb Ben Abdallah, Yousr Gorgi, Imen Sfar
The impact of interleukin-10 (IL-10) gene promoter polymorphisms (SNPs) on treatment response in HCV patients was dissimilarly estimated. Hence, the aim of this meta-analysis was to robustly assess the effect of IL-10 SNPs on treatment response in HCV patients. An electronic literature search was carried out through PubMed, EMBASE, Web of science, and Scopus databases. Studies assessing the association between IL-10 polymorphisms and treatment response in HCV patients were included. Studies were excluded if genotype frequencies are not consistent with the Hardy-Weinberg Equilibrium (HWE) or in case of including patients with hepatitis B virus coinfection...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38519290/promoting-safer-and-wider-worldwide-use-of-clozapine
#11
JOURNAL ARTICLE
Jose de Leon
This issue focuses on the past, the present and the future of clozapine. Of the 43 clozapine articles, nine are historical articles dealing with the past, 29 deal with the present and five with laboratory assays which may influence its future use. These 43 articles include 219 different authors from 56 countries/regions and five continents.
March 22, 2024: Schizophrenia Research
https://read.qxmd.com/read/38519116/national-benchmarks-to-understand-how-doctor-of-physical-therapy-learners-from-minoritized-race-and-ethnicity-groups-perceive-their-physical-therapist-education-program
#12
JOURNAL ARTICLE
Richard K Shields, Julia Chevan, Kai Kennedy, Charlotte Bailey, Shauna Dudley-Javoroski
OBJECTIVE: The demographic homogeneity of the physical therapist workforce and its educational pathway may undermine the profession's potential to improve the health of society. Building academic environments that support the development of all learners is fundamental to building a workforce to meet societal health care needs. The Benchmarking in Physical Therapy Education study uses the Physical Therapy Graduation Questionnaire to comprehensively assess learner perceptions of the physical therapist academic environment...
March 22, 2024: Physical Therapy
https://read.qxmd.com/read/38517645/impact-of-opera-on-resilience-and-thriving-in-serious-mental-illness-pilot-evaluation-of-the-center-cannot-hold-part-2-and-resilience-workshop
#13
JOURNAL ARTICLE
Kenneth B Wells, Lily Zhang, Elyn R Saks, Robert M Bilder
There are few studies of impacts of arts on recovery in schizphrenia, on audience mood and social connection. We developed a pilot evaluation of opera performances in a university setting on Elyn Saks' journey from psychosis, teaching law and falling in love, coupled with pre-opera workshop on approaches to resilience. Using surveys, primary outcomes were pre and post affect (PANAS-X positive, negative; visual "affect grid" touchscreen for affective valence and arousal) and social connectedness with secondary outcomes of increasing understanding, reducing stigma and willingness to socialize or serve persons with mental illness...
March 22, 2024: Community Mental Health Journal
https://read.qxmd.com/read/38516030/comorbidity-burden-in-psoriasis-patients-with-skin-of-color
#14
JOURNAL ARTICLE
Hannah Peterson, Margaret Y Huang, Kathryn Lee, Paige Kingston, Danielle Yee, Edwin Korouri, Rosario Agüero, April W Armstrong
BACKGROUND: Psoriasis is a chronic disease with increased risk of numerous comorbidities. Known differences exist regarding treatment outcomes for psoriasis patients with skin of color (SOC). However, factors contributing to these differences are relatively unknown. OBJECTIVES: This study aims to compare the comorbidity burden in SOC psoriasis patients vs. White patients, as measured by the Charlson Comorbidity Index (CCI) score. METHODS: We utilized the National Ambulatory Medical Care Survey (NAMCS) to identify visits for adult psoriasis patients occurring in the years 2002-2016 and 2018...
January 2024: Journal of Psoriasis and Psoriatic Arthritis
https://read.qxmd.com/read/38515523/does-consumption-of-pearl-millet-cause-goiter-a-systematic-review-of-existing-evidence
#15
Seetha Anitha, Shweta Upadhyay, Stefania Grando, Joanna Kane-Potaka
Millets (defined here to also include sorghum) have been consumed in Asian and African countries for centuries, and have in recent years become increasingly popular in Western countries, especially because of their proven health and environmental benefits. Nevertheless, some concerns have been raised that their consumption can interfere with thyroid function and cause goiter. This systematic review aimed to investigate the link between millet consumption and goiter. We found nine papers that were relevant to this topic and included them in this review...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38515211/diversity-of-cftr-variants-across-ancestries-characterized-using-454-727-uk-biobank-whole-exome-sequences
#16
JOURNAL ARTICLE
Justin E Ideozu, Mengzhen Liu, Bridget M Riley-Gillis, Sri R Paladugu, Fedik Rahimov, Preethi Krishnan, Rakesh Tripathi, Patrick Dorr, Hara Levy, Ashvani Singh, Jeffrey F Waring, Aparna Vasanthakumar
BACKGROUND: Limited understanding of the diversity of variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene across ancestries hampers efforts to advance molecular diagnosis of cystic fibrosis (CF). The consequences pose a risk of delayed diagnoses and subsequently worsened health outcomes for patients. Therefore, characterizing the spectrum of CFTR variants across ancestries is critical for revolutionizing molecular diagnoses of CF. METHODS: We analyzed 454,727 UK Biobank (UKBB) whole-exome sequences to characterize the diversity of CFTR variants across ancestries...
March 21, 2024: Genome Medicine
https://read.qxmd.com/read/38513543/stage-of-diagnosis-and-survival-for-prostate-cancer-among-immigrant-men-in-ontario-canada
#17
JOURNAL ARTICLE
Aisha K Lofters, Stacie-Ann Sammott, Sarah Swayze, Jacqueline L Bender, Shabbir M H Alibhai, Anthony Henry, Kenneth Noel, Geetanjali Datta
INTRODUCTION: We previously identified specific immigrant groups (West African and Caribbean) with increased incidence of prostate cancer in Ontario, Canada. In this population-level retrospective cohort study, we used administrative databases to compare stage of diagnosis, 5-year overall survival and prostate cancer-specific survival for immigrants versus long-term residents of Ontario. METHODS: We linked several provincial-level databases available at ICES, an independent, non-profit research institute...
March 20, 2024: Cancer Epidemiology
https://read.qxmd.com/read/38512297/analysis-and-optimization-of-equitable-us-cancer-clinical-trial-center-access-by-travel-time
#18
JOURNAL ARTICLE
Hassal Lee, Alexander Shakeel Bates, Shawneequa Callier, Michael Chan, Nyasha Chambwe, Andrea Marshall, Mary Beth Terry, Karen Winkfield, Tobias Janowitz
IMPORTANCE: Racially minoritized and socioeconomically disadvantaged populations are currently underrepresented in clinical trials. Data-driven, quantitative analyses and strategies are required to help address this inequity. OBJECTIVE: To systematically analyze the geographical distribution of self-identified racial and socioeconomic demographics within commuting distance to cancer clinical trial centers and other hospitals in the US. DESIGN, SETTING, AND PARTICIPANTS: This longitudinal quantitative study used data from the US Census 2020 Decennial and American community survey (which collects data from all US residents), OpenStreetMap, National Cancer Institute-designated Cancer Centers list, Nature Index of Cancer Research Health Institutions, National Trial registry, and National Homeland Infrastructure Foundation-Level Data...
March 21, 2024: JAMA Oncology
https://read.qxmd.com/read/38509882/the-therapeutic-landscape-for-covid-19-and-post-covid-19-medications-from-genetic-profiling-of-the-vietnamese-population-and-a-predictive-model-of-drug-drug-interaction-for-comorbid-covid-19-patients
#19
JOURNAL ARTICLE
Thien Khac Nguyen, Giang Minh Vu, Vinh Chi Duong, Thang Luong Pham, Nguyen Thanh Nguyen, Trang Thi Ha Tran, Mai Hoang Tran, Duong Thuy Nguyen, Nam S Vo, Huong Thanh Phung, Tham Hong Hoang
Despite the raised awareness of the role of pharmacogenomic (PGx) in personalized medicines for COVID-19, data for COVID-19 drugs is extremely scarce and not even a publication on this topic for post-COVID-19 medications to date. In the current study, we investigated the genetic variations associated with COVID-19 and post-COVID-19 therapies by using whole genome sequencing data of the 1000 Vietnamese Genomes Project (1KVG) in comparison with other populations retrieved from the 1000 Genomes Project Phase 3 (1KGP3) and the Genome Aggregation Database (gnomAD)...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38509598/ethnic-variations-in-metabolic-syndrome-components-and-their-associations-with-the-gut-microbiota-the-helius-study
#20
JOURNAL ARTICLE
Manon Balvers, Marcus de Goffau, Natal van Riel, Bert-Jan van den Born, Henrike Galenkamp, Koos Zwinderman, Max Nieuwdorp, Evgeni Levin
BACKGROUND: The occurrence of metabolic syndrome (MetS) and the gut microbiota composition are known to differ across ethnicities yet how these three factors are interwoven is unknown. Also, it is unknown what the relative contribution of the gut microbiota composition is to each MetS component and whether this differs between ethnicities. We therefore determined the occurrence of MetS and its components in the multi-ethnic HELIUS cohort and tested the overall and ethnic-specific associations with the gut microbiota composition...
March 20, 2024: Genome Medicine
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