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https://www.readbyqxmd.com/read/29243798/effects-of-propofol-or-sevoflurane-anesthesia-on-the-perioperative-inflammatory-response-pulmonary-function-and-cognitive-function-in-patients-receiving-lung-cancer-resection
#1
H-T Tian, X-H Duan, Y-F Yang, Y Wang, Q-L Bai, X Zhang
OBJECTIVE: To investigate the effects of propofol and sevoflurane anesthesia on the inflammatory response, pulmonary function and cognitive function of patients undergoing lung cancer resection and their differences. PATIENTS AND METHODS: 62 patients with lung cancer who underwent pulmonary lobectomy from January 2014 to January 2016 in Jining First People's Hospital were selected and randomly divided into two groups: the propofol group (n=31) and the sevoflurane group (n=31)...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29241764/determining-the-effects-of-green-chemistry-synthesized-ag-nisin-nanoparticle-on-macrophage-cells
#2
Masood Moein, Abbas Ali Imani Fooladi, Hamideh Mahmoodzadeh Hosseini
Bacteriocins are low molecular weight substances produced through post transcriptional changes. These molecules are easily degraded in mammalian gut by proteolytic enzymes especially protease. Nisin is a peptide with 34 aa and its structure contains a pentacyclic lanthionine and 4 beta metyllanthionine residues. Different formulations have been designed for nisin. Since "green synthesis" is a progressive method to prepare anti-microbial and anti-cancer compounds, this study aimed at green synthesis of nisin metal compounds to be used lower concentration still exerting nisin effects...
December 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29239690/antibody-drug-conjugates-design-and-development-for-therapy-and-imaging-in-and-beyond-cancer-labex-mabimprove-industrial-workshop-july-27-28-2017-tours-france
#3
Camille Martin, Claire Kizlik-Masson, André Pèlegrin, Hervé Watier, Marie-Claude Viaud-Massuard, Nicolas Joubert
The annual "Antibody Industrial Symposium", co organized by LabEx MAbImprove, MabDesign and Polepharma, was held in Tours, France on June 27-28, 2017. The focus was on antibody-drug-conjugates (ADCs), new entities which realize the hope of Paul Ehrlich's magic bullet. ADCs result from the bioconjugation of a highly cytotoxic drug to a selective monoclonal antibody, which acts as a vector. Building on knowledge gained during the development of three approved ADCs, brentuximab vedotin (Adcetris®), ado trastuzumab emtansine (Kadcyla®) and inotuzumab ozogamicin (Besponsa®), and the many ADCs in development, this meeting addressed strategies and the latest innovations in the field from fundamental research to manufacturing...
December 14, 2017: MAbs
https://www.readbyqxmd.com/read/29233615/diet-quality-inflammation-and-quality-of-life-in-breast-cancer-survivors-a-cross-sectional-analysis-of-pilot-study-data
#4
Tonya S Orchard, Rebecca R Andridge, Lisa D Yee, Maryam B Lustberg
BACKGROUND: Modifiable lifestyle factors, such as diet quality, could reduce inflammation and improve quality of life (QOL) in breast cancer survivors, but data are inconclusive. OBJECTIVE: To determine whether diet quality, as measured by Healthy Eating Index-2010 (HEI-2010) score, is associated with inflammation, health status, or functional outcomes affecting QOL in survivors of early-stage breast cancer. DESIGN: This is a cross-sectional, secondary analysis of baseline data collected from breast cancer survivors after completion of primary therapy and before random assignment to a pilot nutritional intervention aimed at reducing side effects of aromatase inhibitor treatment...
December 9, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29228651/dietary-feeding-of-freeze-dried-whole-cranberry-inhibits-intestinal-tumor-development-in-apcmin-mice
#5
Duochen Jin, Tianyu Liu, Wenxiao Dong, Yujie Zhang, Sinan Wang, Runxiang Xie, Bangmao Wang, Hailong Cao
It is increasingly perceived that dietary components have been linked with the prevention of intestinal cancer. Cranberry is a rich source of phenolic constituents and non-digestible fermentable dietary fiber, which shows anti-proliferation effect in colorectal cancer cells. Herein, we investigated the efficacy of long-term cranberry diet on intestinal adenoma formation in Apcmin/+ mice. Apcmin/+ mice were fed a basal diet or a diet containing 20% (w/w) freeze-dried whole cranberry powder for 12 weeks, and the number and size of tumors were recorded after sacrifice...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228376/effects-of-cyclophosphamide-cyp-and-or-doxorubicin-dox-in-a-murine-model-of-post-chemotherapy-cognitive-impairment
#6
Timothy J Flanigan, Julie E Anderson, Ikram Elayan, Antiño R Allen, Sherry A Ferguson
Post-chemotherapy cognitive impairment, or PCCI, is a common complaint, particularly among breast cancer patients. However, the exact nature of PCCI appears complex. To model the human condition, ovariectomized C57BL/6J mice were treated iv weekly for 4 weeks with saline, 2 mg/kg doxorubicin (DOX), 50 mg/kg cyclophosphamide (CYP), or DOX+CYP. For the subsequent 10 weeks, mice were assessed on several behavioral tests, including those measuring spatial learning and memory. After sacrifice, hippocampal spine density and morphology in the dentate gyrus, CA1, and CA3 regions were measured...
December 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29227546/high-levels-of-extracellular-atp-lead-to-chronic-inflammatory-response-in-melanoma-patients
#7
Aline Manica, Alexsandra Da Silva, Andreia Machado Cardoso, Marcelo Moreno, Daniela B Leal, Anielen Dutra Da Silva, Maria Rosa Chitolina Schetinger, Vera Maria Morsch, Margarete Dulce Bagatini
Skin cancer represents a serious public health problem and melanoma is considered the most significant due to its high metastasis capacity. Evasion mechanisms are the main characteristic of these tumor cells to escape of immune response. Extracellular nucleotides and nucleosides play an important role in inflammatory and immune responses. In this study, we analyzed the expression and activity of purinergic system enzymes in platelets and lymphocytes, ATP levels quantification, as well the level of pro and anti-inflammatory interleukins in the serum of 23 patients with surgical melanoma removal (CM group) and 23 control subjects (CT group)...
December 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29203590/a-first-in-human-phase-1-study-of-subcutaneous-outpatient-recombinant-human-il-15-rhil-15-in-adults-with-advanced-solid-tumors
#8
Jeffrey S Miller, Chihiro Morishima, Douglas G McNeel, Manish R Patel, Holbrook E Kohrt, John A Thompson, Paul M Sondel, Heather A Wakelee, Mary L Disis, Judith C Kaiser, Martin A Cheever, Howard Streicher, Stephen P Creekmore, Thomas A Waldmann, Kevin C Conlon
PURPOSE: Preclinical data established Interleukin-15 as a homeostatic factor and powerful stimulator of NK and CD8+ T cell function, the basis for clinical testing. EXPERIMENTAL DESIGN: A first-in-human outpatient phase I dose escalation trial of subcutaneous (SC) rhIL-15 was conducted in refractory solid tumor cancer patients. Therapy consisted of daily (Monday - Friday) SC injections of rhIL-15 for two consecutive weeks (10 total doses/cycle). Clinical response was assessed by RECIST...
December 4, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29202657/a-case-of-gastric-cancer-metastasis-to-the-breast-in-a-female-with-brca2-germline-mutation-and-literature-review
#9
Audrius Dulskas, Mahdi Al Bandar, Yoon Young Choi, Su-Jin Shin, Seung-Hoon Beom, Taeil Son, Hyung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh
INTRODUCTION: Gastric cancer is a deadly disease. Common sites of distant metastasis of gastric cancer are the peritoneum, liver, lymph nodes, and lung. The breast is a rare site of metastasis in gastric cancer which occurs in males dominantly. PATIENTS AND METHODS: Here, we report the first case of metastatic gastric cancer to the breast in a patient with the breast cancer 2 (BRCA2) germline mutation. A 34-year-old female was admitted to the hospital with dyspepsia and a palpable mass in the left breast...
December 5, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29198745/orientin-a-c-glycosyl-dietary-flavone-suppresses-colonic-cell-proliferation-and-mitigates-nf-%C3%AE%C2%BAb-mediated-inflammatory-response-in-1-2-dimethylhydrazine-induced-colorectal-carcinogenesis
#10
Kalaiyarasu Thangaraj, Manju Vaiyapuri
Orientin, a C-glycosyl dietary flavone profusely found in rooibos tea and passion fruit have gained much attention owing to their multiple pharmacological potentials. The present study intends to investigate the anti-proliferative and anti-inflammatory efficacy of Orientin in 1,2-dimethyl hydrazine (DMH) induced colorectal cancer (CRC) in rats. Animals were arbitrarily segmented into six groups and fed with high-fat diet. Group 1 served as control. Group 2 received weekly subcutaneous injections of DMH (20 mg/kg b...
December 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29191456/impact-of-systemic-inflammation-on-the-relationship-between-insulin-resistance-and-all-cause-and-cancer-related-mortality
#11
Da Young Lee, Eun-Jung Rhee, Yoosoo Chang, Chong Il Sohn, Ho-Cheol Shin, Seungho Ryu, Won-Young Lee
BACKGROUND: Insulin resistance and inflammation play an important role in a variety of chronic diseases. OBJECTIVE: We investigated the influence of systemic inflammation on the relationship between insulin resistance and mortality risk in apparently healthy adults. METHODS: This study examined the mortality outcomes for 165,849 Koreans enrolled in a health-screening program. The subjects were divided into four groups according to their homeostatic model assessment of insulin resistance (HOMA-IR) and high-sensitivity C-reactive protein (hs-CRP) levels: group 0, HOMA-IR <75% and hs-CRP <2...
November 27, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29188061/effect-of-coriolus-versicolor-glucan-on-the-stimulation-of-cytokine-production-in-sarcoma-180-bearing-mice
#12
Annoor Awadasseid, Kuugbee Eugene, Mayada Jamal, Jie Hou, Ahmed Musa Hago, Yaser Gamallat, Abdo Meyiah, Djibril Bamba, Chiwala Gift, Mohnad Abdalla, Yufang Ma, Yi Xin
Coriolus versicolor (CV) contains high levels of bioactive compounds, including the glucan (1→6)-α-D-glucopyranosyl. However, there is a lack of data regarding the potential effect of this CV glucan (CVG) on the stimulation of cytokine production. The present study evaluated the effect of CVG on the stimulation of cytokine production in sarcoma-180-bearing mice. Mice were treated with three doses of CVG (40, 100 or 200 mg/kg body weight) for nine days, after which serum levels of cytokines, namely interleukin (IL)-2, -4, -6, -10, -17A and interferon (IFN)-α and -γ, were investigated by ELISA...
December 2017: Biomedical Reports
https://www.readbyqxmd.com/read/29187869/fuzi-enhances-anti-tumor-efficacy-of-radiotherapy-on-lung-cancer
#13
Qi Zhang, Xue Chen, Youjun Luo, Huaping Ren, Tiankui Qiao
In traditional Chinese medicine, Fuzi is widely used as an antitumor agent or an adjuvant medication combined with radiotherapy and chemotherapy, but its mechanism remains unclear. In this study, we investigated anti-tumor and immunoregulation efficacy of Fuzi combined with radiotherapy in mice with Lewis lung cancer (LLC). We found that Fuzi combined with radiotherapy significantly inhibited the growth of LLC, promoted the apoptosis of cancer cells, and prolonged the survival of mice with LLC. Mechanistically, we found that Fuzi decreased the proportion of Treg cells, reduced serum levels of cytokines such as interleukin (IL)-10 and transforming growth factor (TGF)-β, and downregulated the expression of programmed death ligand-1 in mice with LLC subjected to radiotherapy...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29187284/jq1-a-bet-inhibitor-controls-tlr4-induced-il-10-production-in-regulatory-b-cells-by-brd4-nf-%C3%AE%C2%BAb-axis
#14
Min Bum Lee, JunHo Lee, Seong Hwi Hong, Jueng Soo You, Seung Taek Nam, Hyun Woo Kim, Young Hwan Park, Dajeong Lee, Keun Young Min, Yeong-Min Park, Young Mi Kim, Hyuk Soon Kim, Wahn Soo Choi
Regulatory B cells, also well-known as IL-10-producing B cells, play a role in the suppression of inflammatory responses. However, the epigenetic modulation of regulatory B cells is largely unknown. Recent studies showed that the bromodomain and extra-terminal domain (BET) protein inhibitor JQ1 controls the expression of various genes involving cell proliferation and cell cycle. However, the role of BET proteins on development of regulatory B cells is not reported. In this study, JQ1 potently suppressed IL-10 expression and secretion in murine splenic and peritoneal B cells...
November 29, 2017: BMB Reports
https://www.readbyqxmd.com/read/29186188/effect-of-age-on-chronic-inflammation-and-responsiveness-to-bacterial-and-viral-challenges
#15
Ingrid Elisia, Vivian Lam, Elyse Hofs, Michael Yu Li, Mariah Hay, Brandon Cho, Angela Brooks-Wilson, Miriam Rosin, Luke Bu, William Jia, Gerald Krystal
To identify reliable biomarkers of age-related changes in chronic inflammation and responsiveness to bacterial and viral challenges, we evaluated endogenous and ex vivo stimulated levels of 18 inflammatory markers, using whole blood collected in EDTA and sodium heparin tubes from 41 healthy volunteers, i.e., 11 men + 10 women aged 20-35 and 10 men + 10 women aged 50-77. These studies revealed significant differences in the levels of inflammatory markers when blood was collected in EDTA versus sodium heparin and age related differences in these biomarkers were confirmed with blood collected in EDTA from 120 healthy volunteers in 3 age categories, ie, 20 men + 20 women, aged 20-35, 36-49 and 50-77...
2017: PloS One
https://www.readbyqxmd.com/read/29182982/moderate-intermittent-negative-pressure-increases-invasiveness-of-mda-mb-231-triple-negative-breast-cancer-cells
#16
Wenyue Liu, Xin Fu, Zhigang Yang, Shangshan Li, Yan Cao, Qiuchen Li, Jie Luan
BACKGROUND: To investigate the effect moderate intermittent negative pressure breast reconstructive model exerts on human triple negative breast cancer cell (TNBC) invasion and explore the related mechanism. METHODS: The human TNBC cell line MDA-MB-231 was used. Cells in external volume expansion (EVE) group were exposed to an intermittent -25 mmHg for 12 h; the pressure for non-EVE group was constantly 0 mmHg. In vivo, MDA-MB-231 cell suspensions were injected subcutaneously into dorsal skin of nude mice (n = 27 mice/group)...
November 25, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29176007/between-biology-and-medicine-perspectives-on-the-use-of-dendritic-cells-in-anticancer-therapy
#17
Agnieszka Szczygieł, Elżbieta Pajtasz-Piasecka
Dendritic cells (DCs), as a link between innate and adaptive immunity, play a pivotal role in maintaining homeostasis of the immune system. The DC population is characterized by heterogeneity; it consists of many subpopulations which, despite their phenotypic and localization differences, play an essential function - they are professional antigen presenting cells. Due to their role, DCs can be utilized in a new cancer treatment strategy. Their main purpose is to generate an anticancer response leading to the elimination of cancer cells...
November 19, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29175261/th17-cytokine-profiling-of-colorectal-cancer-patients-with-or-without-enterovirus-71-antigen-expression
#18
Yazhen Li, Qiancheng Qiu, Zhiqiang Fan, Ping He, Huanzhu Chen, Xiaoyang Jiao
OBJECT: Th17 cytokines have been identified in several types of human cancers. In this pilot study, the expression of Th17 cytokines profiling in enteroviruses 71 (EV71) associated colorectal cancer (CRC) were explored. METHODS: 66 patients with CRC were enrolled in this study; immune- histochemical analyses were performed on cancerous tissues and adjacent non- cancerous tissues of the patients. Serum Th17 cytokines of CRC patients and healthy controls were measured using a Luminex 200 analyzer...
November 23, 2017: Cytokine
https://www.readbyqxmd.com/read/29174861/evaluation-of-saliva-and-plasma-cytokine-biomarkers-in-patients-with-oral-squamous-cell-carcinoma
#19
L T Lee, Y K Wong, H Y Hsiao, Y W Wang, M Y Chan, K W Chang
The aim of this study was to investigate potential biomarkers in human saliva and plasma to aid in the early diagnosis of oral squamous cell carcinoma (OSCC). Saliva and plasma samples obtained from OSCC patients (n=41) and non-oral cancer patients (n=24) were analyzed by Luminex Bead-based Multiplex Assay. Data were analyzed using the non-parametric Mann-Whitney U-test, Kruskal-Wallis test, and receiver operating characteristics curve (ROC) to evaluate the predictive power of 14 biomarkers individually for OSCC diagnosis...
November 23, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29172280/relationships-of-ex-vivo-drug-resistance-assay-and-cytokine-production-with-clinicopathological-features-in-the-primary-cell-culture-of-thai-ovarian-and-fallopian-tube-cancer-patients
#20
May Thuu Mon, Supachai Yodkeeree, Wanisa Punfa, Sonthaya Umsumarng, Suree Lekwanavijit, Sumalee Siriaunkgul, Prapaporn Suprasert, Pornngarm Limtrakul
Objective: Our goal was to determine the ex-vivo drug resistance assay, as well as the cytokine production, in response to platinum-based chemotherapy treatment in primary culture cells established from the tumor tissue of ovarian or fallopian tube carcinoma patients, and to predict the clinical responses to chemotherapy. Methods: Sensitivity to the platinum-based drug was analyzed in two ovarian cancer cell lines and 19 tumor samples using the primary cell culture obtained from 19 patients having ovarian or fallopian tube cancer that had undergone surgery from 2014 to 2017...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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