keyword
MENU ▼
Read by QxMD icon Read
search

Il-10 cancer

keyword
https://www.readbyqxmd.com/read/29690889/effect-of-colorectal-cancer-derived-extracellular-vesicles-on-the-immunophenotype-and-cytokine-secretion-profile-of-monocytes-and-macrophages
#1
Ineta Popēna, Artūrs Ābols, Līga Saulīte, Kārlis Pleiko, Elīna Zandberga, Kaspars Jēkabsons, Edgars Endzeliņš, Alicia Llorente, Aija Linē, Una Riekstiņa
BACKGROUND: Macrophages are one of the most important players in the tumor microenvironment. The polarization status of tumor associated macrophages into a pro-inflammatory type M1 or anti-inflammatory type M2 may influence cancer progression and patient survival. Extracellular vesicles (EVs) are membrane-bound vesicles containing different biomolecules that are involved in cell to cell signal transfer. Accumulating evidence suggests that cancer-derived EVs are taken up by macrophages and modulate their phenotype and cytokine profile...
April 24, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29682678/more-protection-of-lactobacillus-acidophilus-than-bifidobacterium-bifidum-probiotics-on-azoxymethane-induced-mouse-colon-cancer
#2
Shahram Agah, Ali Mohammad Alizadeh, Maryam Mosavi, Peyman Ranji, Hossein Khavari-Daneshvar, Farnaz Ghasemian, Sahar Bahmani, Abbas Tavassoli
Based on the ability of the probiotics in the gut microflora modification, they can have the beneficial effects on diseases in the short and/or the long term. In previous study, we revealed that unlike Bifidobacterium bifidum, the amount of Lactobacillus acidophilus remained almost unchanged in mice gut microflora in the long term, indicating more stability of L. acidophilus than B. bifidum which can be used to prevent some incurable diseases such as cancer. Thirty-eight male BALB/c mice were divided into four groups, control, azoxymethane (AOM), L...
April 22, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29682182/anti-cancerous-effect-of-cis-khellactone-from-angelica-amurensis-through-the-induction-of-three-programmed-cell-deaths
#3
Samil Jung, Hyung-In Moon, Beom Suk Lee, Subeen Kim, Nguyen Thi Ngoc Quynh, Jimin Yu, Dan-Diem Thi Le, Zolzaya Sandag, Hyegyeong Lee, Hyojeong Lee, Nguyen Hai Anh, Young Yang, Jong-Seok Lim, Keun-Il Kim, Myeong-Sok Lee
Angelica amurensis has traditionally been used to treat various medical problems. In this report, we introduce cis-khellactone as a new anti-cancer agent, which was isolated from the chloroform soluble fraction of the rhizomes of Angelica amurensis . Its anti-cancerous effect was at first tested in MCF7 and MDA-MB-231 breast cell lines, in which MCF7 is well known to be resistant to many anti-cancer drugs; MCF10A normal breast cell line was used as a control. In vitro experiments showed that cis-khellactone suppressed cell growth and proliferation at a relatively low concentrations (<5 μg/ml) and decreased cell viability at high concentrations (>10 μg/ml) in both cancer cell lines in a time- and concentration-dependent manner...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29681184/tam-infiltration-differences-in-tumor-first-and-zheng-first-models-and-the-underlying-inflammatory-molecular-mechanism-in-pancreatic-cancer
#4
Feng-Jiao Wang, Peng Wang, Lian-Yu Chen, Ya-Wen Geng, Hao Chen, Zhi-Qiang Meng, Lu-Ming Liu, Zhen Chen
BACKGROUND: Syndrome ( ZHENG in Chinese) in traditional Chinese medicine (TCM) refers to the intrinsic characteristics of a pathological process at a certain stage; these characteristics are influenced by internal and external environments and reveal the nature of a disease. Proper syndrome differentiation is the basic principle that guides clinical treatment. OBJECTIVE: To have a good understanding of tumor progression and the different mechanisms related to ZHENG that have occurred before and after tumor development and to explore the valid evaluation criteria of different pancreatic cancer syndromes to improve the guiding role of TCM syndrome differentiation in pancreatic cancer treatment...
April 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29678767/targeted-inhibition-of-tumor-survival-metastasis-and-angiogenesis-by-acacia-ferruginea-mediated-regulation-of-vegf-inflammatory-mediators-cytokine-profile-and-inhibition-of-transcription-factor-activation
#5
Kunnathur Murugesan Sakthivel, Chandrasekaran Guruvayoorappan
Acacia ferruginea extract (AFE) was studied for anti-metastasis/-angiogenesis activity against B16F-10 melanoma cells in C57BL/6 mice. In vitro cytotoxicity of AFE was first screened using MTT assay and it was shown to inhibit B16F-10 cells with IC50 value of 52.94 μg/ml. Anti-metastatic activity of AFE in vivo revealed administration of AFE (10 mg/kg.b.wt) in three different regimens has shown reduced metastatic colony formation in lungs and prolonged survival in metastatic tumor-bearing hosts. Biochemical analysis shown that treatment with AFE significantly reduced the lung collagen hydroxyproline, hexosamine, uronic acid, sialic acid and gamma-glutamyl transpeptidase content...
April 17, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29676344/histopathological-pattern-of-thyroid-diseases-in-zaria-a-10-year-review
#6
Nasiru Raheem, Saad A Ahmed, Modupeola Oa Samaila
Context: Majority of the previous studies on thyroid diseases in Northern Nigeria focussed mainly on neoplastic lesions. The non-neoplastic lesions are more common and constitute more public health burdens. Aim: To determine the histopathological pattern of thyroid diseases in our region and compare our findings with similar studies in Nigeria and elsewhere. Settings and Design: This is a retrospective study carried out at the Department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria, from January 2005 to December 2014 using specified criteria...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29673765/three-dimensional-ionic-liquid-ferrite-functionalized-graphene-oxide-nanocomposite-for-pipette-tip-solid-phase-extraction-of-16-polycyclic-aromatic-hydrocarbons-in-human-blood-sample
#7
Yun Zhang, Yong-Gang Zhao, Wei-Sheng Chen, He-Li Cheng, Xiu-Qiong Zeng, Yan Zhu
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitously found in the environment and have been proved to be prospectively associated with the risk of cancer. In this study, a simple method based on pipette-tip solid phase extraction (PT-SPE) and gas chromatography-mass spectrometry (GC-MS) has been firstly developed for the determination of 16 PAHs in human whole blood. Three-dimensional ionic liquid-ferrite functionalized graphene oxide nanocomposite (3D-IL-Fe3 O4 -GO) was used as sorbent in PT-SPE. Compared with conventional SPE method, the PT-SPE method was solvent-saving (1...
March 21, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29671891/the-association-of-circulating-inflammation-proteins-and-gallstone-disease
#8
Zhiwei Liu, Troy J Kemp, Yu-Tang Gao, Amanda Corbel, Emma E McGee, Bingsheng Wang, Ming-Chang Shen, Asif Rashid, Ann W Hsing, Allan Hildesheim, Ruth M Pfeiffer, Ligia A Pinto, Jill Koshiol
BACKGROUND: Inflammation plays a role in the development of both gallstones and gallbladder cancer; however, few studies have investigated the association of circulating inflammation proteins with risk of gallstones. METHODS: We measured 13 cytokines (including 10 interleukins), that have been associated with cancer in serum samples collected from 150 gallstone patients and 149 population-based controls from Shanghai, China, in 1997-2001. We estimated the associations of each cytokine, categorized into quartiles and coded as a trend, with risk of gallstones using logistic regression models adjusted for potential confounders...
April 19, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29668679/similarities-and-differences-between-helminth-parasites-and-cancer-cell-lines-in-shaping-human-monocytes-insights-into-parallel-mechanisms-of-immune-evasion
#9
Prakash Babu Narasimhan, Leor Akabas, Sameha Tariq, Naureen Huda, Sasisekhar Bennuru, Helen Sabzevari, Robert Hofmeister, Thomas B Nutman, Roshanak Tolouei Semnani
A number of features at the host-parasite interface are reminiscent of those that are also observed at the host-tumor interface. Both cancer cells and parasites establish a tissue microenvironment that allows for immune evasion and may reflect functional alterations of various innate cells. Here, we investigated how the phenotype and function of human monocytes is altered by exposure to cancer cell lines and if these functional and phenotypic alterations parallel those induced by exposure to helminth parasites...
April 18, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29664967/role-of-il-23-signaling-in-the-progression-of-premalignant-oral-lesions-to-cancer
#10
Blaine Caughron, Yi Yang, M Rita I Young
Mice bearing carcinogen-induced premalignant oral lesions were previously shown to have a pro-inflammatory phenotype, which is replaced with an immune inhibitory phenotype as lesions progress to cancer. Since Th17 cells are prominent at the premalignant lesion state and their levels are supported by IL-23, studies used mice that were IL-23 receptor deficient (IL-23R KO) to determine the requirement for IL-23 signaling in the immunological and clinical status of mice with premalignant oral lesions. The results showed a dependence on IL-23 signaling for the pro-inflammatory state of mice with oral lesions as levels of IL-2, IFN-γ, IL-6, IL-17 and TNF-α were elevated in wildtype mice with premalignant oral lesions, but not in IL-23R KO mice...
2018: PloS One
https://www.readbyqxmd.com/read/29664568/the-role-of-cytokines-in-t-cell-memory-in-health-and-disease
#11
REVIEW
Miro E Raeber, Yves Zurbuchen, Daniela Impellizzieri, Onur Boyman
Upon stimulation with their cognate antigen, naive T cells undergo proliferation and differentiation into effector cells, followed by apoptosis or survival as precursors of long-lived memory cells. These phases of a T-cell response and the ensuing maintenance of memory T cells are shaped by cytokines, most notably interleukin-2 (IL-2), IL-7, and IL-15 that share the common γ chain (γc ) cytokine receptor. Steady-state production of IL-7 and IL-15 is necessary for background proliferation and homeostatic survival of CD4+ and CD8+ memory T cells...
May 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29662549/tumour-necrosis-factor-interferon-gamma-and-interleukins-as-predictive-markers-of-antiprogrammed-cell-death-protein-1-treatment-in-advanced-non-small-cell-lung-cancer-a-pragmatic-approach-in-clinical-practice
#12
Efimia Boutsikou, Kalliopi Domvri, Georgia Hardavella, Dora Tsiouda, Konstantinos Zarogoulidis, Theodoros Kontakiotis
Background: The emergence of novel antiprogrammed cell death protein-1 (PD-1) inhibitors in non-small cell lung cancers (NSCLC) has revolutionized the therapeutic landscape of this disease. Although overall survival (OS) has improved in the first- and second-line therapy settings for advanced NSCLC, the benefit is not universal. In a climate of global scrutiny for healthcare costs and potential for toxicities related to immunotherapy, appropriate patient selection is crucial. The aim of this study was to evaluate potential prognostic and predictive biomarkers interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α) and a panel of interleukins (ILs) in the peripheral blood, and assess any correlation with response to anti-PD-1 inhibition, progression-free survival and OS in NSCLC patients...
2018: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29660336/microrna-155-inversely-correlates-with-esophageal-cancer-progression-through-regulating-tumor-associated-macrophage-fgf2-expression
#13
Peng Wang, Li-Juan Xu, Jie-Jie Qin, Lu Zhang, Gui-Hua Zhuang
Esophageal cancer (EC) is one of the most common malignancies with high incidence and mortality. Tumor-associated macrophages (TAMs) in the tumor microenvironment have been linked to the accelerated tumor progression. MicroRNAs (miR) are 19-25 nucleotide-long, noncoding RNA molecules, functioning as modulators of gene expression, and mediate a variety of biological functions, including tumor growth. In the present study, the effects and molecular mechanism of miR-155 in TAMs isolated from EC were explored. The expression of miR-155 and fibroblast growth factor-2 (FGF2) in EC tissues and cell lines were analyzed using reverse transcription-quantitative PCR (qRT-PCR) and western blot assays...
April 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29659349/control-of-body-temperature-and-immune-function-in-patients-undergoing-open-surgery-for-gastric-cancer
#14
Li Shao, Nannan Pang, Ping Yan, Fengju Jia, Qi Sun, Wenjuan Ma, Yi Yang
The influence of mild perioperative hypothermia on the immune function and incidence of postoperative wound infections has been suggested, but the specific mechanism is unclear. This study aimed to analyze the body temperature, immune function, and wound infection rates in patients receiving open surgery for gastric cancer. Body temperature was controlled in each patient using one of four different methods: wrapping limbs, head and neck; insulated blankets; warming infusion fluids and insulated blankets; and warming fluids without insulated blankets...
April 9, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29656182/co-culture-of-ovarian-cancer-stem-like-cells-with-macrophages-induced-skov3-cells-stemness-via-il-8-stat3-signaling
#15
Yingxia Ning, Yinghong Cui, Xiang Li, Xiaocheng Cao, A Chen, Chang Xu, Jianguo Cao, Xin Luo
Among recent concepts in the cancer biology field, the tumor microenvironment is highly associated with cancer stem cells, and plays a key role in tumor progression. This study aimed to explore the mechanism that the stemness induction of SKOV3 cell line by macrophages derived from THP-1 cells, which was co-cultured with SKOV3-derived ovarian cancer stem-like cells (OCSLCs). Sphere formation, soft agar colony formation, and expression levels of CD133 and CD44 were assessed to reflect OCSLC properties. ELISA was used to evaluate secretion profile changes in macrophages co-cultured with or without SKOV3-derived OCSLCs...
April 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29648818/imidazole-alkaloids-and-their-zinc-complexes-from-the-calcareous-marine-sponge-leucetta-chagosensis
#16
Wei-Zhuo Tang, Zhong-Zhen Yang, Wei Wu, Jie Tang, Fan Sun, Shu-Ping Wang, Chun-Wei Cheng, Fan Yang, Hou-Wen Lin
Five new imidazole derivatives (1-5), together with eight related known alkaloids, were isolated from a calcareous marine sponge, Leucetta chagosensis, collected from the South China Sea. Their structures were fully characterized by spectroscopic methods. Structurally, 1 possesses an unusual skeleton featuring imidazole and oxazolone rings linked via a nitrogen atom, whereas 2 bears an intriguing guanylurea-substituted imidazole ring. Compounds 4 and 5 were identified as zinc complexes; they represent the metal complex analogues of naamidine J (6) and pyronaamidine (7), respectively...
April 12, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29629026/effect-of-vitamin-c-on-azoxymethane-aom-dextran-sulfate-sodium-dss-induced-colitis-associated-early-colon-cancer-in-mice
#17
Hee-Jin Jeon, Yiseul Yeom, Yoo-Sun Kim, Eunju Kim, Jae-Ho Shin, Pu Reum Seok, Moon Jea Woo, Yuri Kim
BACKGROUND/OBJECTIVES: The objective of this study was to investigate the effects of vitamin C on inflammation, tumor development, and dysbiosis of intestinal microbiota in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced inflammation-associated early colon cancer mouse model. MATERIALS/METHODS: Male BALB/c mice were injected intraperitoneally with AOM [10 mg/kg body weight (b.w)] and given two 7-d cycles of 2% DSS drinking water with a 14 d inter-cycle interval...
April 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29628986/chronological-improvement-in-survival-of-patients-with-breast-cancer-a-large-scale-single-center-study
#18
Sae Byul Lee, Guiyun Sohn, Jisun Kim, Il Yong Chung, Hee Jeong Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Sung-Bae Kim, Sei-Hyun Ahn
Purpose: This study aimed to chronologically evaluate survival of patients with breast cancer in Korea and investigate the observed changes during the last 20 years. We also sought to determine factors that may influence outcomes and changes in the duration of survival over time. Methods: We retrospectively analyzed a total of 10,988 patients with breast cancer who were treated at our institution between January 1993 and December 2008. We divided the study period into three periods (P1, 1993-1997; P2, 1998-2002; and P3, 2003-2008)...
March 2018: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29628312/alt-803-an-il-15-superagonist-in-combination-with-nivolumab-in-patients-with-metastatic-non-small-cell-lung-cancer-a-non-randomised-open-label-phase-1b-trial
#19
John M Wrangle, Vamsidhar Velcheti, Manish R Patel, Elizabeth Garrett-Mayer, Elizabeth G Hill, James G Ravenel, Jeffrey S Miller, Mohammad Farhad, Kate Anderton, Kathryn Lindsey, Michele Taffaro-Neskey, Carol Sherman, Samantha Suriano, Marzena Swiderska-Syn, Amy Sion, Joni Harris, Andie R Edwards, Julie A Rytlewski, Catherine M Sanders, Erik C Yusko, Mark D Robinson, Carsten Krieg, William L Redmond, Jack O Egan, Peter R Rhode, Emily K Jeng, Amy D Rock, Hing C Wong, Mark P Rubinstein
BACKGROUND: Immunotherapy with PD-1 or PD-L1 blockade fails to induce a response in about 80% of patients with unselected non-small cell lung cancer (NSCLC), and many of those who do initially respond then develop resistance to treatment. Agonists that target the shared interleukin-2 (IL-2) and IL-15Rβγ pathway have induced complete and durable responses in some cancers, but no studies have been done to assess the safety or efficacy of these agonists in combination with anti-PD-1 immunotherapy...
April 5, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29626227/effect-of-internal-contamination-with-tritiated-water-on-the-neoplastic-colonies-in-the-lungs-innate-anti-tumour-reactions-cytokine-profile-and-haematopoietic-system-in-radioresistant-and-radiosensitive-mice
#20
Ewa M Nowosielska, Aneta Cheda, Robert Zdanowski, Sławomir Lewicki, Bobby R Scott, Marek K Janiak
Tritium is a potentially significant source of internal radiation exposure which, at high levels, can be carcinogenic. We evaluated whether single intraperitoneal injection of BALB/c and C57BL/6 mice with tritiated water (HTO) leading to exposure to low (0.01 or 0.1 Gy) and intermediate (1.0 Gy) cumulative whole-body doses of β radiation is immunosuppressive, as judged by enhancement of artificial tumour metastases, functioning of NK lymphocytes and macrophages, circulating cytokine's levels, and numbers of bone marrow, spleen, and peripheral blood cells...
April 6, 2018: Radiation and Environmental Biophysics
keyword
keyword
38159
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"