keyword
MENU ▼
Read by QxMD icon Read
search

Il-10 cancer

keyword
https://www.readbyqxmd.com/read/29453736/reproductive-epidemiology-of-glial-tumors-may-reveal-novel-treatments-high-dose-progestins-or-progesterone-antagonists-as-endocrino-immune-modifiers-against-glioma
#1
REVIEW
Meric A Altinoz, Aysel Ozpinar, Ilhan Elmaci
Female gender, contraceptives, and menopausal hormone replacement treatments containing progesterone analogues associate with higher risk of meningiomas yet with lower risk of gliomas. Progesterone receptor (PR) expression and mifepristone treatment was highly discussed for meningiomas. However, much less is known in regard to progesterone actions in gliomas despite PR expression strongly correlates with their grade. Meningiomas and gliomas may grow faster during gestation; but paradoxically, parousity reduces lifetime risk of gliomas which can be explained with dichotomous cell growth-stimulating and inhibitory actions of progesterone at low versus high levels...
February 17, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29448205/6-7-dimethoxy-1-2-3-4-tetrahydro-isoquinoline-3-carboxylic-acid-attenuates-colon-carcinogenesis-via-blockade-of-il-6-mediated-signals
#2
Priyanka Mishra, Vinit Raj, Archana S Bhadauria, Ashok K Singh, Amit Rai, Pranesh Kumar, Amit K Keshari, Arnab De, Amalesh Samanta, Umesh Kumar, Dinesh Kumar, Biswanath Maity, Sneha Nath, Anand Prakash, Kausar M Ansari, Sudipta Saha
In this study, we investigated the in vivo antiproliferative activity of 6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (M1) in dimethylhydrazine (DMH) induced colorectal carcinoma (CRC) using albino Wistar rats. M1 was administered to DMH induced CRC rats at 10 and 25 mg/kg doses for 15 days. Various physiological, oxidative parameters, histopathology, ELISA, gene and protein expression studies were conducted to evaluate the anti-CRC potential of M1. The histopathology and biochemical tests indicated the protective action of M1 in DMH-induced colon cancer...
February 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29446048/adiponectin-and-colon-cancer-evidence-for-inhibitory-effects-on-viability-and-migration-of-human-colorectal-cell-lines
#3
E Nigro, P Schettino, R Polito, O Scudiero, M L Monaco, G D De Palma, A Daniele
Adiponectin (Acrp30) is an adipokine widely studied for its beneficial metabolic and anti-inflammatory properties. Colorectal cancer is among the most common cancers worldwide. The aim of present study was to explore the effects of Acrp30 on both CaCo-2 and HCT116 colorectal cancer cells in terms of viability, oxidative stress, and apoptosis. In addition, since colorectal cancer represents a typical inflammation-related cancer, we investigated whether Acrp30 treatment modifies the migration and the expression of crucial proteins in the EMT transition...
February 14, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29440917/association-between-il-17a-g197a-polymorphism-and-gastric-cancer-risk-an-updated-meta-analysis-based-on-6-624-cases-and-7-631-controls
#4
Lixia Hu, Fanliang Kong, Yueyin Pan
Purpose: Previous studies investigating the association between interleukin-17A (IL-17A) G197A polymorphism and gastric cancer risk have provided inconsistent results. We, therefore, conducted this meta-analysis to clarify the association between IL-17A G197A polymorphism and gastric cancer risk. Methods: We searched PubMed, Excerpta Medica Database, and CNKI databases to identify relevant studies up to June 10, 2017. A total of 16 case-control studies including 6,624 cases and 7,631 controls were identified...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29440769/epithelial-mesenchymal-transition-emt-signature-is-inversely-associated-with-t-cell-infiltration-in-non-small-cell-lung-cancer-nsclc
#5
Young Kwang Chae, Sangmin Chang, Taeyeong Ko, Jonathan Anker, Sarita Agte, Wade Iams, Wooyoung M Choi, Kyoungmin Lee, Marcelo Cruz
Epithelial-mesenchymal transition (EMT) is able to drive metastasis during progression of multiple cancer types, including non-small cell lung cancer (NSCLC). As resistance to immunotherapy has been associated with EMT and immune exclusion in melanoma, it is important to understand alterations to T-cell infiltration and the tumor microenvironment during EMT in lung adenocarcinoma and squamous cell carcinoma. We conducted an integrated analysis of the immune landscape in NSCLCs through EMT scores derived from a previously established 16 gene signature of canonical EMT markers...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29435821/7-8-dihydroxycoumarin-exerts-antitumor-potential-on-dmba-induced-mammary-carcinogenesis-by-inhibiting-er%C3%AE-pr-egfr-and-igf1r-involvement-of-mapk1-2-jnk1-2-akt-pathway
#6
Abhishek Kumar, Priyashree Sunita, Shivesh Jha, Shakti P Pattanayak
Breast cancer (BC) is a persistent and impulsive metabolic disorder with the highest prevalence in women, worldwide. 7,12-Dimethylbenz(a)anthracene (DMBA) is a potent polyaromatic hydrocarbon (PAH)-based carcinogen producing mammary carcinomas in rats resembling the human hormone-dependent BC. 7,8-Dihydroxycoumarin (78DC) is a coumarin derivative that possesses diversified and favorable pharmacology profile to be considered in anticancer research against various malignancies. The present study was intended to investigate the antiproliferative and chemotherapeutic potentials of 78DC (20, 40, and 80 mg/kg BW) against DMBA (20 mg in olive oil)-induced mammary carcinoma Sprague-Dawley rats...
February 12, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29435761/fibroblasts-potentiate-melanoma-cells-in-vitro-invasiveness-induced-by-uv-irradiated-keratinocytes
#7
Njainday Pulo Jobe, Veronika Živicová, Alžběta Mifková, Daniel Rösel, Barbora Dvořánková, Ondřej Kodet, Hynek Strnad, Michal Kolář, Aleksi Šedo, Karel Smetana, Karolina Strnadová, Jan Brábek, Lukáš Lacina
Melanoma represents a malignant disease with steadily increasing incidence. UV-irradiation is a recognized key factor in melanoma initiation. Therefore, the efficient prevention of UV tissue damage bears a critical potential for melanoma prevention. In this study, we tested the effect of UV irradiation of normal keratinocytes and their consequent interaction with normal and cancer-associated fibroblasts isolated from melanoma, respectively. Using this model of UV influenced microenvironment, we measured melanoma cell migration in 3-D collagen gels...
February 12, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29434884/endostatin-reverses-immunosuppression-of-the-tumor-microenvironment-in-lung-carcinoma
#8
Xiaolin Liu, Weiwei Nie, Qi Xie, Guoling Chen, Xingyu Li, Yanrui Jia, Beibei Yin, Xun Qu, Yan Li, Jing Liang
Endostatin has previously been demonstrated to efficiently inhibit the angiogenesis and growth of endothelial cells. However, the role of endostatin in the tumor microenvironment remains to be elucidated. To investigate the antitumor effect of endostatin in lung cancer, the present study was designed to explore the alterations of microvessel density in Lewis lung cancer models and the expression of vascular endothelial growth factor (VEGF), interleukin (IL)-6, IL-17, interferon (IFN)-γ and hypoxia inducible factor (HIF)-1α, following endostatin therapy...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434856/high-fat-diet-induced-adipokine-and-cytokine-alterations-promote-the-progression-of-prostate-cancer-in-vivo-and-in-vitro
#9
Meng-Bo Hu, Hua Xu, Wen-Hui Zhu, Pei-De Bai, Ji-Meng Hu, Tian Yang, Hao-Wen Jiang, Qiang Ding
High-fat diet (HFD) -induced obesity is associated with more aggressive and lethal prostate cancer (PCa) in males, although the exact underlying mechanisms remain unclear. In the present study, transgenic adenocarcinoma of mouse prostate (TRAMP) models fed on an HFD (40% fat) or a control diet (CD; 16% fat) were generated, and cancer differentiation, local invasion and metastasis were compared at 20, 24 and 28 weeks. Mouse sera from each group were collected, and adipokines and cytokines were measured using multiplex immunoassays...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434755/anti-tumour-effects-of-polysaccharide-extracted-from-acanthopanax-senticosus-and-cell-mediated-immunity
#10
Qinglong Meng, Jingzhi Pan, Yajing Liu, Li Chen, Yueying Ren
Acanthopanax senticosus, also known as Siberian ginseng, is widely distributed throughout northern Asia and used in traditional Chinese medicine; it has been reported to prevent a number of diseases. However, the association between the antitumour and immunostimulatory activities of polysaccharide extracted from A. senticosus (ASPS) remains to be elucidated. The aim of the present study was to investigate the anti-tumour and immunomodulatory effects of polysaccharide extracted from ASPS on Crocker sarcoma S180, hepatic carcinoma H22 and uterine cervical carcinoma U14 tumour cell lines implanted in mice...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29429965/mast-cells-promote-small-bowel-cancer-in-a-tumor-stage-specific-and-cytokine-dependent-manner
#11
Abdulrahman M Saadalla, Abu Osman, Michael F Gurish, Kristen L Dennis, Nichole R Blatner, Abdulmohammad Pezeshki, Kelly M McNagny, Hilde Cheroutre, Fotini Gounari, Khashayarsha Khazaie
Mast cells (MCs) are tissue resident sentinels that mature and orchestrate inflammation in response to infection and allergy. While they are also frequently observed in tumors, the contribution of MCs to carcinogenesis remains unclear. Here, we show that sequential oncogenic events in gut epithelia expand different types of MCs in a temporal-, spatial-, and cytokine-dependent manner. The first wave of MCs expands focally in benign adenomatous polyps, which have elevated levels of IL-10, IL-13, and IL-33, and are rich in type-2 innate lymphoid cells (ILC2s)...
February 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29429524/nintedanib-effects-on-delaying-cancer-progression-and-decreasing-cox-2-and-il-17-in-the-prostate-anterior-lobe-in-tramp-mice
#12
Letícia Ferreira Alves, Raquel Frenedoso da Silva, Valéria Helena Alves Cagnon
Prostate cancer is the most prevalent type of cancer in men around the world. Due to its high incidence, new therapies have been evaluated, including drugs capable of inhibiting the FGF/VEGF pathways, as Nintedanib. The aim herein was to evaluate the Nintedanib therapeutic effects on morphology and COX-2 and IL-17 levels in the prostate anterior lobe in different grades of the tumor progression in TRAMP mice. Animals were treated with Nintedanib at a dose of 10 mg/kg/day in initial and intermediate grades of tumor development...
February 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29425215/friend-virus-limits-adaptive-cellular-immune-responses-by-imprinting-a-maturation-resistant-and-t-helper-type-2-biased-immunophenotype-in-dendritic-cells
#13
Limei Shen, Stefan Tenzer, Moritz Hess, Ute Distler, Ingrid Tubbe, Evelyn Montermann, Simone Schimmer, Ulf Dittmer, Stephan Grabbe, Matthias Bros
The murine Friend virus (FV) retrovirus model has been widely used to study anti-viral immune responses, and virus-induced cancer. Here we analyzed FV immune evasion mechanisms on the level of dendritic cells (DC) essential for the induction of primary adaptive immune responses. Comparative quantitative proteome analysis of FV-infected DC (FV-DC) of different genotypes (BALB/c, C57BL/6) and non-infected DC revealed numerous genotype-independently regulated proteins rergulating metabolic activity, cytoskeletal rearrangements, and antigen processing/presentation...
2018: PloS One
https://www.readbyqxmd.com/read/29420993/glucagon-like-peptide-2-improves-intestinal-immune-function-and-diminishes-bacterial-translocation-in-a-mouse-model-of-parenteral-nutrition
#14
Qiucheng Lei, Jingcheng Bi, Huanwei Chen, Feng Tian, Xuejin Gao, Ning Li, Xinying Wang
Parenteral nutrition (PN) is associated with increased infectious risks due to impaired intestinal immunity. Although glucagon-like peptide-2 (GLP-2) enhances the gut barrier function, it is uncertain whether it improves mucosal immunologic barrier function. We hypothesized that injecting the PN mouse model with GLP-2 improved innate and acquired immunity, and prevented bacterial translocation. Forty-eight hours after venous cannulation, male Institute of Cancer Research mice were randomly divided into 3 groups based on their diet: chow with saline (n = 10), PN (n = 9), or PN + GLP-2 (30 μg bid per mouse, n = 10) provided for 5 days...
January 2018: Nutrition Research
https://www.readbyqxmd.com/read/29417228/comparison-of-long-term-clinical-outcomes-between-endoscopic-and-surgical-resection-for-early-stage-adenocarcinoma-of-the-esophagogastric-junction
#15
Hyun Ju Kim, Hyunsoo Chung, Sung Kwan Shin, Hyoung-Il Kim, Jun Chul Park, Sang Kil Lee, Woo Jin Hyung, Yong Chan Lee, Sung Hoon Noh
BACKGROUND: The aim of this study was to analyze long-term clinical and oncologic outcomes in patients with early-stage adenocarcinoma of the esophagogastric junction (AEG) managed with either endoscopic resection (ER) or surgery. METHODS: The inclusion criteria were AEG, meeting classic or expanded indications for ER of early gastric cancer, and complete resection. A total of 66 patients with Siewert type II AEG were included (ER group, n = 38; vs. surgery group, n = 28)...
February 7, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29416719/response-to-stereotactic-ablative-radiotherapy-in-a-novel-orthotopic-model-of-non-small-cell-lung-cancer
#16
Ayman Oweida, Siham Sabri, Areej Al-Rabea, Mojgan Ebrahimi, Russel Ruo, Richard Fraser, Jan Seuntjens, Bassam Abdulkarim
Stereotactic ablative radiotherapy (SABR) is the main treatment for inoperable early-stage non-small cell lung cancer (NSCLC). Despite the widespread use of SABR, the biological determinants of response to SABR remain poorly investigated. We developed an orthotopic NSCLC animal model to study the response to clinically-relevant doses of SABR. Image-guided intra-thoracic injection of NSCLC cells was performed in the right lung of nude rats. A highly conformal dose of 34 Gy was delivered in a single fraction using clinical photon energies...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415668/the-effect-of-propofol-and-sevoflurane-on-cancer-cell-natural-killer-cell-and-cytotoxic-t-lymphocyte-function-in-patients-undergoing-breast-cancer-surgery-an-in-vitro-analysis
#17
Jeong-Ae Lim, Chung-Sik Oh, Tae-Gyoon Yoon, Ji Yeon Lee, Seung-Hyun Lee, Young-Bum Yoo, Jung-Hyun Yang, Seong-Hyop Kim
BACKGROUND: To clarify the effect of anaesthetic agents on cancer immunity, we evaluated the effects of propofol and sevoflurane on natural killer (NK) cell, cytotoxic T lymphocyte (CTL) counts and apoptosis rate in breast cancer and immune cells co-cultures from patients who underwent breast cancer surgery. METHODS: Venous blood samples were collected after inducing anaesthesia and at 1 and 24 h postoperatively in patients who had undergone breast cancer surgery...
February 7, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29408308/inflammatory-gene-polymorphisms-in-lung-cancer-susceptibility
#18
Keith D Eaton, Perrin E Romine, Gary E Goodman, Mark D Thornquist, Matt J Barnett, Effie W Petersdorf
INTRODUCTION: Chronic inflammation has been implicated in carcinogenesis, with increasing evidence of its role in lung cancer. We aim to evaluate the role of genetic polymorphisms in inflammation-related genes in the risk for developing lung cancer. METHODS: Using a nested case-control study design, 625 cases and 625 well-matched controls were selected from participants in the CARET study, a large, prospective lung cancer chemoprevention trial. The association between lung cancer incidence and survival and 23 polymorphisms descriptive of 11 inflammation-related genes (interferon γ, IL-10, IL-1α, IL-1β, IL-2, IL-4R, IL-4, IL-6, PTGS2 (COX-2), TGF-β1, and TNFα) was evaluated...
February 2, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29405562/low-bmi-is-correlated-with-increased-tgf-%C3%AE-and-il-10-mrna-levels-in-the-peripheral-blood-of-breast-cancer-patients
#19
Chao Liu, Qian Wang, Bing Sun, Xiangying Meng, Lan Li, Liuchun Yang, Yang Cong, Jiannan Liu, Liang Xuan, Yan Huang, Shikai Wu
Transforming growth factor-β (TGF-β), interleukin-10 (IL-10), and forkhead box P3 (Foxp3) have important roles in breast cancer development. Previous studies confirmed a correlation between these immune molecules and tumor characteristics, but their association with nutritional status in breast cancer is largely unknown. We aimed to investigate the association between body mass index (BMI), hemoglobin, total protein, albumin, globulin (GLB), albumin/GLB ratio (AGR), pre-albumin, prognostic nutritional index, and TGF-β, IL-10, and Foxp3 mRNA expression in patients with breast cancer...
February 5, 2018: IUBMB Life
https://www.readbyqxmd.com/read/29401621/il-10-suppresses-tnf-%C3%AE-induced-expression-of-human-aromatase-gene-in-mammary-adipose-tissue
#20
Gabriela Martínez-Chacón, Kristy A Brown, Maria M Docanto, Himanshu Kumar, Seppo Salminen, Niina Saarinen, Sari Mäkelä
White adipose tissue inflammation is linked with increased aromatase gene expression and estrogen production, a major risk factor for breast cancer in obese postmenopausal women. TNF-α, a proinflammatory cytokine, is a key driver of aromatase promoter I.4-mediated expression in adipose tissue. In this study, we have shown that IL-10, an anti-inflammatory cytokine, suppressed both TNF-α-stimulated human aromatase reporter-luciferase (hARO-Luc) expression in mouse bone marrow mesenchymal stromal cells and aromatase gene expression in human breast adipose stromal cells (ASCs)...
January 23, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
keyword
keyword
38159
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"