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https://www.readbyqxmd.com/read/28791253/potential-role-of-metabolic-intervention-in-the-management-of-advanced-differentiated-thyroid-cancer
#1
Sri Harsha Tella, Anuhya Kommalapati, Mary Angelynne Esquivel, Ricardo Correa
Well-differentiated thyroid carcinoma (DTC) is the most common endocrine malignancy that has an excellent prognosis with a 5-year survival rate of about 98%. However, approximately 50% of the patients with DTC who present with distant metastases (advanced DTC) die from the disease within 5 years of initial diagnosis even after getting the appropriate therapy. Apart from recent advancements in chemotherapy agents, the potential role of metabolic interventions, including the use of metformin, ketogenic diet, and high-dose vitamin C in the management of advanced cancers have been investigated as a less toxic co-adjuvant therapies...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28778055/the-effect-of-the-ketogenic-diet-on-the-developing-skeleton
#2
Peter J Simm, Jillian Bicknell-Royle, Jock Lawrie, Judy Nation, Kellie Draffin, Karen G Stewart, Fergus J Cameron, Ingrid E Scheffer, Mark T Mackay
The ketogenic diet (KD) is a medically supervised, high fat, low carbohydrate and restricted protein diet which has been used successfully in patients with refractory epilepsy. Only one published report has explored its effect on the skeleton. We postulated that the KD impairs skeletal health parameters in patients on the KD. Patients commenced on the KD were enrolled in a prospective, longitudinal study, with monitoring of Dual-energy X-ray absorptiometry (DXA) derived bone parameters including bone mineral content and density (BMD)...
July 26, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28764104/co-fermentation-of-sewage-sludge-with-ryegrass-for-enhancing-hydrogen-production-performance-evaluation-and-kinetic-analysis
#3
Guang Yang, Jianlong Wang
The low C/N ratio and low carbohydrate content of sewage sludge limit its application for fermentative hydrogen production. In this study, perennial ryegrass was added as the co-substrate into sludge hydrogen fermentation with different mixing ratios for enhancing hydrogen production. The results showed that the highest hydrogen yield of 60mL/g-volatile solids (VS)added was achieved when sludge/perennial ryegrass ratio was 30:70, which was 5 times higher than that from sole sludge. The highest VS removal of 21...
July 18, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28759939/effects-of-a-low-calorie-low-carbohydrate-soy-containing-diet-on-systemic-inflammation-among-patients-with-nonalcoholic-fatty-liver-disease-a-parallel-randomized-clinical-trial
#4
Ali Hashemi Kani, Seyed Moayed Alavian, Ahmad Esmaillzadeh, Peyman Adibi, Fahimeh Haghighatdoost, Leila Azadbakht
Few studies have focused on the effects of a soy containing diet on inflammation and serum leptin level among patients with nonalcoholic fatty liver disease (NAFLD). Therefore, we aimed to determine the effects of such a diet in patients with NAFLD. Forty-five patients with NAFLD participated in this parallel randomized clinical trial for 8 weeks. Patients were randomly allocated to these 3 groups: 1) a low-calorie diet, 2) low-calorie low-carbohydrate diet, and 3) low-calorie low-carbohydrate soy containing diet...
July 31, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28752977/-correlation-between-dietary-nutrition-and-premature-ovarian-failure
#5
Hui Chen, Ran Cheng, Liang-Zhi Xu
OBJECTIVE: To explore the relationship between dietary nutrition and premature ovarian failure (POF). METHODS: A case control study was undertaken in 294 patients recruited from the reproductive endocrine clinic of our hospital over the period from November 2015 to January 2017. The POF group included women with premature ovarian failure , and women with normal menstruation were included as control group. The dietary and nutritional status of these patients were analyzed and compared...
July 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28752053/dietary-sugars-not-lipids-drive-hypothalamic-inflammation
#6
Yuanqing Gao, Maximilian Bielohuby, Thomas Fleming, Gernot F Grabner, Ewout Foppen, Wagner Bernhard, Mara Guzmán-Ruiz, Clarita Layritz, Beata Legutko, Erwin Zinser, Cristina García-Cáceres, Ruud M Buijs, Stephen C Woods, Andries Kalsbeek, Randy J Seeley, Peter P Nawroth, Martin Bidlingmaier, Matthias H Tschöp, Chun-Xia Yi
OBJECTIVE: The hypothalamus of hypercaloric diet-induced obese animals is featured by a significant increase of microglial reactivity and its associated cytokine production. However, the role of dietary components, in particular fat and carbohydrate, with respect to the hypothalamic inflammatory response and the consequent impact on hypothalamic control of energy homeostasis is yet not clear. METHODS: We dissected the different effects of high-carbohydrate high-fat (HCHF) diets and low-carbohydrate high-fat (LCHF) diets on hypothalamic inflammatory responses in neurons and non-neuronal cells and tested the hypothesis that HCHF diets induce hypothalamic inflammation via advanced glycation end-products (AGEs) using mice lacking advanced glycation end-products (AGEs) receptor (RAGE) and/or the activated leukocyte cell-adhesion molecule (ALCAM)...
August 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28752049/beta-adrenergic-receptors-are-critical-for-weight-loss-but-not-for-other-metabolic-adaptations-to-the-consumption-of-a-ketogenic-diet-in-male-mice
#7
Nicholas Douris, Bhavna N Desai, Ffolliott M Fisher, Theodore Cisu, Alan J Fowler, Eleen Zarebidaki, Ngoc Ly T Nguyen, Donald A Morgan, Timothy J Bartness, Kamal Rahmouni, Jeffrey S Flier, Eleftheria Maratos-Flier
OBJECTIVE: We have previously shown that the consumption of a low-carbohydrate ketogenic diet (KD) by mice leads to a distinct physiologic state associated with weight loss, increased metabolic rate, and improved insulin sensitivity [1]. Furthermore, we identified fibroblast growth factor 21 (FGF21) as a necessary mediator of the changes, as mice lacking FGF21 fed KD gain rather than lose weight [2]. FGF21 activates the sympathetic nervous system (SNS) [3], which is a key regulator of metabolic rate...
August 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28750216/efficacy-of-low-carbohydrate-diet-for-type-2-diabetes-mellitus-management-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#8
REVIEW
Yan Meng, Hao Bai, Shijun Wang, Zhaoping Li, Qian Wang, Liyong Chen
AIMS: The objective of this systematic review and meta-analysis is to assess the efficacy of Low Carbohydrate Diet (LCD) compared with a normal or high carbohydrate diet in patients with type 2 diabetes. METHODS: We searched MEDLINE, EMBASE, and Cochrane Library database for randomized controlled trials. Researches which reported the change in weight loss, blood glucose, and blood lipid levels were included. RESULTS: A total of 9 studies with 734 patients with diabetes were included...
July 8, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28747486/modifying-the-dietary-carbohydrate-to-protein-ratio-alters-the-postprandial-macronutrient-oxidation-pattern-in-liver-of-ampk-deficient-mice
#9
Tristan Chalvon-Demersay, Patrick C Even, Catherine Chaumontet, Julien Piedcoq, Benoit Viollet, Claire Gaudichon, Daniel Tomé, Marc Foretz, Dalila Azzout-Marniche
Background: Hepatic AMP-activated kinase (AMPK) activity is sensitive to the dietary carbohydrate-to-protein ratio. However, the role of AMPK in metabolic adaptations to variations in dietary macronutrients remains poorly understood.Objective: The objective of this study was to determine the role of hepatic AMPK in the adaptation of energy metabolism in response to modulation of the dietary carbohydrate-to-protein ratio.Methods: Male 7-wk-old wild-type (WT) and liver AMPK-deficient (knockout) mice were fed either a normal-protein and normal-carbohydrate diet (NP-NC; 14% protein, 76% carbohydrate on an energy basis), a low-protein and high-carbohydrate diet (LP-HC; 5% protein, 85% carbohydrate), or a high-protein and low-carbohydrate diet (HP-LC; 55% protein, 35% carbohydrate) for 3 wk...
July 26, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28733520/the-ketogenic-diet-is-not-feasible-as-a-therapy-in-a-cd-1-nu-nu-mouse-model-of-renal-cell-carcinoma-with-features-of-stauffer-s-syndrome
#10
Silvia Vidali, Sepideh Aminzadeh-Gohari, René Günther Feichtinger, Renaud Vatrinet, Andreas Koller, Felix Locker, Tricia Rutherford, Maura O'Donnell, Andrea Stöger-Kleiber, Bridget Lambert, Thomas Klaus Felder, Wolfgang Sperl, Barbara Kofler
The ketogenic diet (KD), a high-fat low-carbohydrate diet, has shown some efficacy in the treatment of certain types of tumors such as brain tumors and neuroblastoma. These tumors are characterized by the Warburg effect. Because renal cell carcinoma (RCC) presents similar energetic features as neuroblastoma, KD might also be effective in the treatment of RCC. To test this, we established xenografts with RCC 786-O cells in CD-1 nu/nu mice and then randomized them to a control diet or to KDs with different triglyceride contents...
July 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28711517/prevention-of-type-2-diabetes-mellitus-in-polycystic-ovary-syndrome-a-review
#11
REVIEW
Safa Anwar, Nigar Shikalgar
Polycystic ovary syndrome (PCOS) is recognized as one of the most common endocrinopathies in women of reproductive age, associated with metabolic sequelae which includes increased risk factors for impaired glucose tolerance (IGT), type 2 diabetes mellitus (DM2) and cardiovascular disease (CVD). The adverse effects of DM2 affects a woman throughout her lifespan. Health care expenditure of DM2 highlights the need for prevention through appropriate screening, diagnosis and intervention. Lifestyle modification (LSM) programs that include diet and/or physical activity are suggested for patients characterized as prediabetic to delay the onset of adult DM2...
July 8, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28708478/diabetes-with-obesity-is-there-an-ideal-diet
#12
REVIEW
Zahrae Sandouk, M Cecilia Lansang
For individuals who are overweight or obese, weight loss is effective in preventing and improving the management of type 2 diabetes. Together with other lifestyle factors like exercise and behavior modification, diet plays a central role in achieving weight loss. Diets vary based on the type and amount of carbohydrate, fat, and protein consumed to meet daily caloric intake goals. A number of popular diets are reviewed as well as studies evaluating the effect of various diets on weight loss, diabetes, and cardiovascular risk factors...
July 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28706467/ketogenic-diet-benefits-body-composition-and-well-being-but-not-performance-in-a-pilot-case-study-of-new-zealand-endurance-athletes
#13
Caryn Zinn, Matthew Wood, Mikki Williden, Simon Chatterton, Ed Maunder
BACKGROUND: Low-carbohydrate, high-fat and ketogenic diets are increasingly adopted by athletes for body composition and sports performance enhancements. However, as yet, there is no consensus on their efficacy in improving performance. There is also no comprehensive literature on athletes' experiences while undertaking this diet. The purpose of this pilot work was two-fold: i. to examine the effects of a non-calorie controlled ketogenic diet on body composition and performance outcomes of endurance athletes, and ii...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28701319/low-carbohydrate-diet-induces-metabolic-depression-a-possible-mechanism-to-conserve-glycogen
#14
Hugh Stirling Winwood-Smith, Craig E Franklin, Craig R White
Long-term studies have found low carbohydrate diets are more effective for weight loss than calorie restricted diets in the short-term, but equally or only marginally more effective in the long-term. Low carbohydrate diets have been linked to reduced glycogen stores and increased feelings of fatigue. We propose that reduced physical activity in response to lowered glycogen explains the diminishing weight loss advantage of low carbohydrate compared to low calorie diets over longer time scales. We explored this possibility by feeding adult Drosophila melanogaster either a standard or low carbohydrate diet for nine days and measured changes in metabolic rate, glycogen stores, activity, and body mass...
July 12, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28700832/a-12-week-low-carbohydrate-high-fat-lchf-diet-improves-metabolic-health-outcomes-over-a-control-diet-in-a-randomised-controlled-trial-with-overweight-defence-force-personnel
#15
Caryn Zinn, Julia McPhee, Nigel Kent Harris, Micalla Williden, Kate Prendergast, Grant Schofield
INTRODUCTION: Overweight, obesity and poor health is becoming a global concern for defence force personnel. Conventional nutrition guidelines are being questioned for their efficacy in achieving optimal body composition and long-term health. This study compared the effects of a 12-week low-carbohydrate, high-fat diet with a conventional, high-carbohydrate, low-fat diet on weight reduction and metabolic health outcomes in at-risk New Zealand Defence Force personnel. MATERIALS AND METHODS: In this randomised controlled trial, 41 overweight personnel were assigned to intervention and control groups...
July 12, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28694840/hepatic-adipocyte-enteric-and-pancreatic-hormones-response-to-dietary-macronutrient-composition-and-relationship-with-metabolism
#16
Bridget M Hron, Cara B Ebbeling, Henry A Feldman, David S Ludwig
BACKGROUND: We sought to characterize the effects of dietary macronutrient composition on various hormones implicated in the regulation of insulin sensitivity (IS) and energy expenditure (EE). METHODS: Following 10-15% weight loss, 21 overweight subjects consumed 3 weight-loss maintenance diets [low fat (LF), low glycemic index (LGI) and very low carbohydrate (VLC)] in random order, each for 4 weeks. At baseline and at the end of each treatment period, fasting samples for fibroblast growth factor (FGF)-21, heme-oxygenase-1 (HO-1), chemerin, irisin, secreted frizzle-related protein (SFRP-4), total bile acids, ghrelin, gastrin inhibitory peptide (GIP), peptide-Y, and amylin; hepatic and peripheral IS; and EE were obtained...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28681340/fdg-pet-ct-findings-of-extra-thoracic-sarcoid-are-associated-with-cardiac-sarcoid-a-rationale-for-using-fgd-pet-ct-for-cardiac-sarcoid-evaluation
#17
Darshan C Patel, Senthil S Gunasekaran, Christopher Goettl, Nadera J Sweiss, Yang Lu
PURPOSE: This retrospective study investigates the relationship between cardiac and extra-thoracic sarcoid findings on FDG PET-CT using a 72-hour pretest high-fat, high-protein, and very low-carbohydrate (HFHPVLC) diet. PATIENTS AND METHODS: A total of 196 consecutive FDG PET-CT scans with 72-hour HFHPVLC diet preparation were performed between December 2014 and December 2015 in known sarcoid patients. Of these scans, 5 were excluded for non-adherence to diet preparation or underlying cancer...
July 5, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28679551/pretreatment-fasting-plasma-glucose-and-insulin-modify-dietary-weight-loss-success-results-from-3-randomized-clinical-trials
#18
Mads F Hjorth, Christian Ritz, Ellen E Blaak, Wim Hm Saris, Dominique Langin, Sanne Kellebjerg Poulsen, Thomas Meinert Larsen, Thorkild Ia Sørensen, Yishai Zohar, Arne Astrup
Background: Which diet is optimal for weight loss and maintenance remains controversial and implies that no diet fits all patients.Objective: We studied concentrations of fasting plasma glucose (FPG) and fasting insulin (FI) as prognostic markers for successful weight loss and maintenance through diets with different glycemic loads or different fiber and whole-grain content, assessed in 3 randomized trials of overweight participants.Design: After an 8-wk weight loss, participants in the DiOGenes (Diet, Obesity, and Genes) trial consumed ad libitum for 26 wk a diet with either a high or a low glycemic load...
August 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28679144/low-carbohydrate-diet-score-and-its-association-with-the-risk-of-diabetes-a-systematic-review-and-meta-analysis-of-cohort-studies
#19
Nazli Namazi, Bagher Larijani, Leila Azadbakht
The association between a low-carbohydrate diet (LCD) score and the risk of diabetes mellitus (DM) is contradictory. This study is a systemic review of cohort studies that have focused on the association between the LCD score and DM. We searched PubMed/Medline, Scopus, Embase, ISI Web of Science, and Google Scholar for papers published through January 2017 with no language restrictions. Cohort studies that reported relative risks (RRs) with 95% confidence intervals (CI) for DM were included. Finally, 4 studies were considered for our meta-analysis...
August 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28669141/development-of-a-new-lactic-acid-bacterial-inoculant-for-fresh-rice-straw-silage
#20
Jong Geun Kim, Jun Sang Ham, Yu Wei Li, Hyung Soo Park, Chul-Sung Huh, Byung-Chul Park
OBJECTIVE: Effects of newly isolated Lactobacillus plantarum on the fermentation and chemical composition of fresh rice straw silage was evaluated in this study. METHODS: Lactic acid bacteria (LAB) from good crop silage were screened by growing them in MRS broth and a minimal medium with low carbohydrate content. Selected LAB (LAB 1821) were Gram-positive, rods, catalase negative, and were identified to be Lactobacillus plantarum based on their biochemical characteristics and a 16S rRNA analysis...
July 2017: Asian-Australasian Journal of Animal Sciences
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