keyword
https://read.qxmd.com/read/38491725/retrospective-study-to-compare-the-effectiveness-of-minimally-invasive-microscopic-unilateral-laminotomy-with-microscopic-bilateral-laminotomy-for-bilateral-decompression-in-the-early-postoperative-period-in-142-patients-with-single-level-lumbar-spinal-stenosis
#21
JOURNAL ARTICLE
Bülent Gülensoy, Serkan Şimşek
BACKGROUND We aimed to compare the effectiveness of microscopic unilateral laminotomy for bilateral decompression (ULBD) and microscopic bilateral laminotomy for bilateral decompression (BLBD) in the early postoperative period among patients with single-level lumbar spinal stenosis (LSS). MATERIAL AND METHODS A retrospective cohort study was conducted on patients with LSS who underwent ULBD or BLBD between January 2020 and December 2023, including 94 patients who underwent ULBD and 58 who underwent BLBD. Patient demographics, comorbidities, smoking status, and data related to LSS were reviewed...
March 16, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/38491541/towards-leaving-no-one-behind-in-north-macedonia-a-mixed-methods-assessment-of-barriers-to-effective-coverage-with-health-services
#22
JOURNAL ARTICLE
Theadora Swift Koller, Jelena Kjetkovikj Janeva, Elena Ognenovska, Ana Vasilevska, Simona Atanasova, Chris Brown, Antoni Dedeu, Anne Johansen
BACKGROUND: The Government of North Macedonia's Primary Health Care reform is committed to leaving no one behind on the path to Universal health Coverage (UHC). During mid-2022 to March 2023, the World Health Organization (WHO) collaborated with the Government and other national stakeholders for an assessment of barriers to effective coverage with health services experienced by adult citizens, with a specific focus on rural areas and subpopulations in situations of vulnerability. METHODS: This study constituted the piloting of a draft forthcoming WHO handbook on assessing barriers for health services, grounded in the Tanahashi framework for effective coverage with health services...
March 15, 2024: International Journal for Equity in Health
https://read.qxmd.com/read/38491434/utilizing-the-national-early-warning-score-2-news2-to-confirm-the-impact-of-emergency-department-management-in-sepsis-patients-a-cohort-study-from-taiwan-1998-2020
#23
JOURNAL ARTICLE
Ming-Shun Hsieh, Kuan-Chih Chiu, Amrita Chattopadhyay, Tzu-Pin Lu, Shu-Hui Liao, Chia-Ming Chang, Yi-Chen Lee, Wei-En Lo, Vivian Chia-Rong Hsieh, Sung-Yuan Hu, Chorng-Kuang How
BACKGROUND: Most sepsis patients could potentially experience advantageous outcomes from targeted medical intervention, such as fluid resuscitation, antibiotic administration, respiratory support, and nursing care, promptly upon arrival at the emergency department (ED). Several scoring systems have been devised to predict hospital outcomes in sepsis patients, including the Sequential Organ Failure Assessment (SOFA) score. In contrast to prior research, our study introduces the novel approach of utilizing the National Early Warning Score 2 (NEWS2) as a means of assessing treatment efficacy and disease progression during an ED stay for sepsis...
March 15, 2024: International Journal of Emergency Medicine
https://read.qxmd.com/read/38491431/the-implementation-of-a-perioperative-medicine-for-older-people-undergoing-surgery-service-a-qualitative-case-study
#24
JOURNAL ARTICLE
Margot E Lodge, Jugdeep Dhesi, David Jh Shipway, Philip Braude, Catherine Meilak, Judith Partridge, Nadine E Andrew, Velandai Srikanth, Darshini R Ayton, Chris Moran
BACKGROUND: The international scale and spread of evidence-based perioperative medicine for older people undergoing surgery (POPS) services has not yet been fully realised. Implementation science provides a structured approach to understanding factors that act as barriers and facilitators to the implementation of POPS services. In this study, we aimed to identify factors that influence the implementation of POPS services in the UK. METHODS: A qualitative case study at three UK health services was undertaken...
March 15, 2024: BMC Health Services Research
https://read.qxmd.com/read/38491427/using-team-based-precision-medicine-to-advance-understanding-of-rare-genetic-brain-disorders
#25
REVIEW
Steven U Walkley, Sophie Molholm, Bryen Jordan, Robert W Marion, Melissa Wasserstein
We describe a multidisciplinary teamwork approach known as "Operation IDD Gene Team" developed by the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center (RFK IDDRC) at the Albert Einstein College of Medicine. This initiative brings families affected by rare genetic diseases that cause intellectual and developmental disability together with physicians, basic scientists, and their trainees. At team meetings, family members share their child's medical and personal history, physicians describe the broader clinical consequences of the condition, and scientists provide accessible tutorials focused on the fundamental biology of relevant genes...
March 15, 2024: Journal of Neurodevelopmental Disorders
https://read.qxmd.com/read/38491407/bilateral-vertebral-artery-injury-leads-to-brain-death-following-traumatic-brain-injury-a-case-report
#26
JOURNAL ARTICLE
Vera Irawany, Vizzi A F Nasution, Noorcahya Amalia
BACKGROUND: Vertebral artery injury is a rare condition in trauma settings. In the advanced stages, it causes death. CASE: A 31-year-old Sundanese woman with cerebral edema, C2-C3 anterolisthesis, and Le Fort III fracture after a motorcycle accident was admitted to the emergency room. On the fifth day, she underwent arch bar maxillomandibular application and debridement in general anesthesia with a hyperextended neck position. Unfortunately, her rigid neck collar was removed in the high care unit before surgery...
March 16, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38491363/applying-narrative-medicine-to-prepare-empathetic-healthcare-providers-in-undergraduate-pharmacy-education-in-singapore-a-mixed-methods-study
#27
JOURNAL ARTICLE
Zhe Han, Keith C Barton, Li-Ching Ho, Kai Zhen Yap, Doreen Su-Yin Tan, Shuh Shing Lee, Constance Xue Rui Neo, Amanda Han Lin Tan, Brian Ming Yao Boey, Charis Jia Yan Soon, Paul J Gallagher
BACKGROUND: Narrative medicine demonstrated positive impact on empathy in medicine and nursing students. However, this pedagogical approach had not been evaluated in pharmacy education. This study sought to apply and evaluate the narrative medicine approach in extending empathy in Asian undergraduate pharmacy students. METHODS: Narrative medicine was applied through workshops which used narratives of people with different experiences and perspectives. First-year undergraduate pharmacy students who volunteered and attended these workshops formed the intervention group (N = 31) and the remaining first-year cohort formed the control group (N = 112)...
March 15, 2024: BMC Medical Education
https://read.qxmd.com/read/38491322/from-degraded-to-deciphered-atac-seq-s-application-potential-in-forensic-diagnosis
#28
JOURNAL ARTICLE
Manrui Li, Yuntian Jin, Yang Xu, Yihan Sun, Ruixuan Yuan, Xiao Zhang, Shengqiu Qu, Meili Lv, Miao Liao, Weibo Liang, Lin Zhang, Xiameng Chen
In recent years, molecular biology-based diagnostic techniques have made remarkable strides and are now extensively utilized in clinical practice, providing invaluable insights for disease diagnosis and treatment. However, forensic medicine, especially forensic pathology, has witnessed relatively limited progress in the application of molecular biology technologies. A significant challenge in employing molecular techniques for forensic diagnoses lies in the quantitative and qualitative changes observed in diagnostic markers due to sample degradation-a recognized and formidable obstacle...
March 16, 2024: International Journal of Legal Medicine
https://read.qxmd.com/read/38491309/mechanism-of-formation-of-p-benzylenephenol-peroxide-radical-p-phc-o-2-%C3%A2-hphoh
#29
JOURNAL ARTICLE
Gregory A Poskrebyshev
CONTEXT: The reactions of radicals with O2 play the important role in the biological, medicinal, and industrial processes. The mechanism of this reaction is studied previously for the alkane, alkene, alkyne, phenols, and close-related radicals. According to these studies, the formation of intermediates in these reactions is predicted only for the aromatic radicals. Thus, the Van der Waals complexes of O2 with phenyl or benzyl radicals are predicted, as well as the π-π cluster for benzene...
March 16, 2024: Journal of Molecular Modeling
https://read.qxmd.com/read/38491238/occurrence-and-health-risk-of-pesticide-residues-in-chinese-herbal-medicines-from-shandong-province-china
#30
JOURNAL ARTICLE
Fangfang Chen, Tianliang Zhang, Peirui Xiao, Lijun Shao, Xinxin Zhang, Lin Wang, Xiaofei Ren, Chuan Qin, Yanni Jiao
Pesticide residue was one of the stress factors affecting quality and safety of Chinese herbal medicines (CHMs). The present study was designed to investigate the occurrence and dietary exposure of 70 pesticide residues in 307 samples of CHMs, including 104 American ginseng, 100 Ganoderma lucidum (G. lucidum), and 103 Dendrobium officinale (D. officinale) in Shandong Province, China. The study revealed that a total of 29 pesticides were detected in the majority (92.5%) of samples, and the pesticide residues of 85 (27...
March 16, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38491169/global-oral-health-policies-and-recommendations-for-children-with-special-health-care-needs-and-their-applicability-and-effectiveness-during-the%C3%A2-covid-19-pandemic-a-systematic-review
#31
JOURNAL ARTICLE
Mousumi Goswami, Bhawna Saxena, Shivya Tuli, Bakhtawar Shakil, Supriya Bhatara, Sanjesh Padha
AIM: This systematic review aims to assess effectiveness of oral health policies, recommendations and guidelines in safeguarding oral health of children with special healthcare needs during COVID-19. BACKGROUND: This systematic review evaluated the adaptation of global oral health policies for children with special healthcare needs (SHCN) during the COVID-19 pandemic, to provide evidence-based insights to inform policymakers and healthcare providers amid the ongoing global health crisis...
March 15, 2024: Evidence-based Dentistry
https://read.qxmd.com/read/38490931/early-and-accurate-diagnosis-of-steatotic-liver-by-artificial-intelligence-ai-supported-ultrasonography
#32
JOURNAL ARTICLE
Sergio Santoro, Mohamad Khalil, Hala Abdallah, Ilaria Farella, Antonino Noto, Giovanni Marco Dipalo, Piercarlo Villani, Leonilde Bonfrate, Agostino Di Ciaula, Piero Portincasa
OBJECTIVES: Steatotic liver disease is the most frequent chronic liver disease worldwide. Ultrasonography (US) is commonly employed for the assessment and diagnosis. Few information is available on the possible use of artificial intelligence (AI) to ameliorate the diagnostic accuracy of ultrasonography. MATERIALS AND METHODS: An AI-based algorithm was developed using a dataset of US images. We prospectively enrolled 134 patients for algorithm validation. Patients underwent abdominal US and Proton Density Fat Fraction MRI scans (MRI-PDFF), assumed as reference technique...
March 14, 2024: European Journal of Internal Medicine
https://read.qxmd.com/read/38490703/warfarin-induced-spontaneous-gastric-intramural-haematoma-presenting-with-palpitations
#33
JOURNAL ARTICLE
Chun Ho Szeto, Joud Enabi, Alejandra Garcia Fernandez
Spontaneous gastric intramural haematoma is an uncommon complication associated with anticoagulant therapy. A patient receiving chronic warfarin for paroxysmal atrial fibrillation was admitted due to atrial fibrillation with rapid ventricular response (RVR). An incidental intra-abdominal mass was detected on a CT scan. Following the initiation of the amiodarone infusion, the patient experienced bleeding attributed to warfarin-amiodarone-induced coagulopathy, with no identifiable bleeding source. Subsequent CT scans revealed an enlargement of the intra-abdominal mass, suggesting gastric intramural haematoma...
March 15, 2024: BMJ Case Reports
https://read.qxmd.com/read/38490479/how-to-detect-non-institutionalized-older-patients-at-risk-of-malnutrition-during-their-hospitalization-comparison-of-8-screening-tools-for-malnutrition-or-nutritional-risk
#34
JOURNAL ARTICLE
Isabel García-Fuente, Luis Corral-Gudino, Miriam Gabella-Martín, Victoria Eugenia Olivet-de-la-Fuente, Julia Pérez-Nieto, Pablo Miramontes-González
BACKGROUND: The prevalence of malnutrition is high among the elderly population. Hospital admission is a window of opportunity for its detection. OBJECTIVE: To assess the concordance of different nutritional scales in hospitalized patients. METHODS: Prospective study in non-institutionalized patients over 65 years of age admitted to an internal medicine department. Five malnutrition screening surveys (MNA, MST, MUST, NRS-2000 and CONUT) and three nutritional risk screening surveys (SCREEN 3, 8 and 14) were compared...
March 13, 2024: Revista Clínica Espanõla
https://read.qxmd.com/read/38490392/in-vitro-and-in-vivo-characterization-of-human-serum-albumin-based-pegylated-nanoparticles-for-bdnf-and-nt3-codelivery
#35
JOURNAL ARTICLE
Maria Dąbkowska, Iga Stukan, Alicja Kosiorowska, Alicja Szatanik, Karolina Łuczkowska, Anna Machalińska, Bogusław Machaliński
The utilization of neurotrophins in medicine shows significant potential for addressing neurodegenerative conditions, such as age-related macular degeneration (AMD). However, the therapeutic use of neurotrophins has been restricted due to their short half-life. Here, we aimed to synthesize PEGylated nanoparticles based on electrostatic-driven interactions between human serum albumin (HSA), a carrier for adsorption; neurotrophin-3 (NT3); and brain-derived neurotrophic factor (BDNF). Electrophoretic (ELS) and multi-angle dynamic light scattering (MADLS) revealed that the PEGylated HSA-NT3-BDNF nanoparticles ranged from 10 to 430 nm in diameter and exhibited a low polydispersity index (<0...
March 13, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38490305/autonomic-nerve-function-predicts-risk-of-early-death-after-discharge-in-acute-medical-disease
#36
JOURNAL ARTICLE
Rakin Hadad, Steen B Haugaard, Philip Bonde Christensen, Ayse Sarac, Maria Helena Dominguez, Ahmad Sajadieh
BACKGROUND: Heart rate variability, a marker of autonomic function, has shown promising prognostic results in specific populations, but has not been tested in a general medical population. We hypothesize that heart rate variability identifies high-risk medical patients early after admission to the hospital. METHOD: A single-center prospective cohort study of acutely admitted medical patients, age ≥18 years old, and life expectancy ≥3 months included between 2019-2023...
March 13, 2024: American Journal of Medicine
https://read.qxmd.com/read/38490228/systematic-endoscopic-staging-of-mediastinum-to-guide-radiotherapy-planning-in-patients-with-locally-advanced-non-small-cell-lung-cancer-seismic-an-international-multicentre-single-arm-clinical-trial
#37
JOURNAL ARTICLE
Daniel P Steinfort, Gargi Kothari, Neil Wallace, Nicholas Hardcastle, Kanishka Rangamuwa, Edith M T Dieleman, Percy Lee, Peixuan Li, Julie A Simpson, Shaun Yo, Farzad Bashirdazeh, Phan Nguyen, Barton R Jennings, David Fielding, Laurence Crombag, Louis B Irving, Kazuhiro Yasufuku, Jouke T Annema, David E Ost, Shankar Siva
BACKGROUND: Systematic mediastinal lymph node staging by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) improves accuracy of staging in patients with early-stage non-small-cell lung cancer (NSCLC). However, patients with locally advanced NSCLC commonly undergo only selective lymph node sampling. This study aimed to determine the proportion of patients with locally advanced NSCLC in whom systematic endoscopic mediastinal staging identified PET-occult lymph node metastases, and to describe the consequences of PET-occult disease on radiotherapy planning...
March 11, 2024: Lancet Respiratory Medicine
https://read.qxmd.com/read/38490078/extending-the-grading-of-recommendations-assessment-development-and-evaluation-grade-in-traditional-chinese-medicine-tcm-the-grade-tcm
#38
JOURNAL ARTICLE
Qin-Wei Fu, Yang Liu, Shu-Cheng Chen, Lan-Zhi Zhang, Wei-Ting Liu, Zhi-Qing Liu, Ying Liu, Yan Xie, Li Fu, Min Liu, Da-Zheng Zhang, Sha-Sha Yang, Fu-Bin Zhang, He-Yin Huang, Juan Zhong, Kai-Yun Pang, Yong-Na Chen, Ye-Peng Yang, Meng-Lin Dai, Shu-Yun Liu, Shi-Peng Zhang, Feng Xiang, Mi Tang, Pei-Jia Li, Cai-Shan Fang, Qin-Xiu Zhang, Wing-Fai Yeung, Xin-Rong Li
AIM: To extend and form the "Grading of Recommendations Assessment, Development and Evaluation in Traditional Chinese Medicine" (GRADE-TCM). METHODS: Methodologies were systematically reviewed and analyzed concerning evidence-based TCM guidelines worldwide. A survey questionnaire was developed based on the literature review and open-end expert interviews. Then, we performed expert consensus, discussion meeting, opinion collection, external examination, and the GRADE-TCM was formed eventually...
February 27, 2024: Phytomedicine
https://read.qxmd.com/read/38490042/liquid-chromatography-coupled-to-tandem-mass-spectrometry-lc-ms-ms-methods-for-the-therapeutic-drug-monitoring-of-cytotoxic-anticancer-drugs-an-update
#39
REVIEW
M Briki, A Murisier, M Guidi, C Seydoux, T Buclin, C Marzolini, F R Girardin, Y Thoma, S Carrara, E Choong, L A Decosterd
In the era of precision medicine, there is increasing evidence that conventional cytotoxic agents may be suitable candidates for therapeutic drug monitoring (TDM)- guided drug dosage adjustments and patient's tailored personalization of non-selective chemotherapies. To that end, many liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) assays have been developed for the quantification of conventional cytotoxic anticancer chemotherapies, that have been comprehensively and critically reviewed...
February 3, 2024: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/38489869/characteristics-of-atopic-dermatitis-patients-using-complementary-and-alternative-medicine-a-literature-review
#40
JOURNAL ARTICLE
C Delhomme, T Adam, H Seiller, A-C Bursztejn
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease. Due to the burden of the disease, some patients try complementary and alternative medicine (CAM). OBJECTIVE: To identify characteristics associated with CAM use in children and adults with AD. METHODS: We conducted a literature review in accordance with the PRISMA international guidelines for literature reviews and meta-analyses. A systematic search was performed in the PubMed database...
March 14, 2024: Annales de Dermatologie et de Vénéréologie
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