keyword
https://read.qxmd.com/read/38493408/a-novel-mitochondrial-unfolded-protein-response-related-risk-signature-to-predict-prognosis-immunotherapy-and-sorafenib-sensitivity-in-hepatocellular-carcinoma
#1
JOURNAL ARTICLE
Sidi Zhang, Hanyao Guo, Hongyu Wang, Xiaopeng Liu, Meixia Wang, Xiaoyu Liu, Yumei Fan, Ke Tan
Hepatocellular carcinoma (HCC) is a common cause of cancer-associated death worldwide. The mitochondrial unfolded protein response (UPRmt ) not only maintains mitochondrial integrity but also regulates cancer progression and drug resistance. However, no study has used the UPRmt to construct a prognostic signature for HCC. This work aimed to establish a novel signature for predicting patient prognosis, immune cell infiltration, immunotherapy, and chemotherapy response based on UPRmt -related genes (MRGs). Transcriptional profiles and clinical information were obtained from the TCGA and ICGC databases...
March 17, 2024: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/38493350/more-than-metrics-the-role-of-socio-environmental-factors-in-determining-the-success-of-athlete-monitoring
#2
JOURNAL ARTICLE
Emma Neupert, Tim Holder, Luke Gupta, Simon A Jobson
The perceived value of athlete monitoring systems (AMS) has recently been questioned. Poor perceptions of AMS are important, because where practitioners lack confidence in monitoring their ability to influence programming, and performance is likely diminished. To address this, researchers have primarily sought to improve factors related to monitoring metrics, e.g., validity rather than socio-environmental factors, e.g., buy-in. Seventy-five practitioners (response rate: n  = 30) working with Olympic and Paralympic athletes were invited to take part in a survey about their perceptions of AMS value...
March 17, 2024: Journal of Sports Sciences
https://read.qxmd.com/read/38493329/opioid-versus-benzodiazepine-based-sedation-for-mechanically-ventilated-patients-in-the-internal-medicine-ward
#3
JOURNAL ARTICLE
Natan Argaman, Avraham Meyer, Nisim Ifrach, Sara Dichtwald
BACKGROUND: Opioid-base sedation is considered the first line choice in ventilated patients in intensive care units (ICU). Few studies have examined sedation in ventilated patients outside the ICU. A pilot program was initiated in the internal medicine ward A at Meir Hospital in Kfar Saba, Israel. A new sedation protocol was implemented for opioid-based versus benzodiazepine-based sedation in ventilated patients. OBJECTIVES: To compare the rates and intensity of delirium between patients who received opioid-based sedation vs...
March 2024: Israel Medical Association Journal: IMAJ
https://read.qxmd.com/read/38493296/analysis-of-wet-pack-incidence-in-steam-sterilization-a-study-in-a-chinese-medical-center
#4
JOURNAL ARTICLE
Yanhua Chen, Li Bao, Liangying Yi, Ruixue Hu
BACKGROUND Central sterile supply departments (CSSDs) play a vital role in hospital infection control. We investigate the factors associated with wet pack occurrence after steam sterilization. MATERIAL AND METHODS We designed a log sheet to record information concerning sterilized packs. The data included the type of sterilized pack; outside weather (sunny, overcast, or rainy); the item in the sterilized pack; packaging material; whether the item had been packaged in compliance with guidelines; whether the pack had been laid flat, upright, or leaning at an acute angle; which sterilizer was used for sterilization of the pack; whether the pack had been placed on the top or bottom shelf inside the sterilizer chamber; whether the pack had been loaded in compliance with guidelines; the drying time following sterilization; and cooling time after sterilization...
March 17, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/38493295/capitate-proximal-fragment-migration-compressing-the-median-nerve-in-scaphocapitate-fracture-a-case-report
#5
JOURNAL ARTICLE
Vasileios Giannatos, Theodoros Stavropoulos, Charalampos Charalampous-Kefalas, Panagiotis Antzoulas, Andreas Panagopoulos, Zinon Kokkalis
BACKGROUND Scaphocapitate syndrome is a rare clinical entity consisting of a combined scaphoid and capitate fracture along with a 90- or 180-degrees rotation of the proximal capitate fragment. The syndrome is scarcely described in the literature, with proximal migration of the capitate fragment being reported only by Mudgal et al in 1995. Concurrent compression of the median nerve is a highly unfortunate event, suggesting a unique case presented here. CASE REPORT We present a unique case of scaphocapitate fracture-dislocation in a 25-year-old man with volar dislocation of the capitate's fragment deep to the median nerve...
March 17, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38493267/objective-and-subjective-measures-of-air-pollution-and-self-rated-health-the-evidence-from-chile
#6
JOURNAL ARTICLE
Yenniel Mendoza, Ricardo E González
PURPOSE: The literature exploring individual differences in self-rated health has grown fast in recent years. Self-rated health (SRH) is a good indicator of general health status. This empirical study explores the association between outdoor air pollution and SRH in Chile. This type of analysis is infrequent in Latin America. METHODS: We used objective and subjective air pollution measures. The first corresponds to PM2.5 , and the latter to the perception of a high level of air pollution...
March 16, 2024: International Archives of Occupational and Environmental Health
https://read.qxmd.com/read/38492767/sustainable
#7
JOURNAL ARTICLE
Sarah Richards, Tisha Wang, E Dale Abel, Mark Linzer, Debra Romberger
No abstract text is available yet for this article.
March 14, 2024: American Journal of Medicine
https://read.qxmd.com/read/38492563/structural-and-compositional-changes-in-two-marine-shell-traditional-chinese-medicines-a-comparative-analysis-pre-and-post-calcination
#8
JOURNAL ARTICLE
Lizhu Wu, Chenlu Liu, Tao Yao, Yun Shi, Jinyang Shen, Xun Gao, Qin Kunming
BACKGROUND: Arcae concha and Meretricis concha cyclinae concha are two marine shellfish herbs with similar composition and efficacy, which are usually calcined and used clinically. OBJECTIVE: This study investigated variations in the inorganic and organic components of Arcae concha and Meretricis concha cyclinae concha from different production regions, both Arcae concha and Meretricis concha cyclinae concha. The aim was to enhance the understanding of these two types of marine shell traditional Chinese medicine (msTCM) and provide a foundation for their future development and application...
March 16, 2024: Journal of AOAC International
https://read.qxmd.com/read/38492339/protective-effect-of-carbon-dots-as-antioxidants-on-intestinal-inflammation-by-regulating-oxidative-stress-and-gut-microbiota-in-nematodes-and-mouse-models
#9
JOURNAL ARTICLE
Nannan Peng, Jingmin Wang, Haimei Zhu, Ziyue Liu, Jiayi Ren, Wenjing Li, Yongzhong Wang
Inflammatory bowel disease (IBD) is a recurrent chronic colitis disease with increasing incidence and prevalence year by year. The single efficacy and significant side effects of traditional IBD treatment drugs have promoted the flourishing development of new drugs. Inspired by many health benefits of carbon dots (CDs) based nanomedicine in biomedical applications, a metal-free carbon dots (CP-CDs) was synthesized from citric acid and polyethylene polyamine to treat colitis. Oxidative stress tests at the cellular and nematode levels demonstrated CP-CDs have good antioxidant effects, while the toxicity of CP-CDs to cells and nematodes is low...
March 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38492332/structural-and-organizational-determinants-of-the-capacity-for-covid-19-testing-and-diagnoses-in-children-insights-from-the-2009-influenza-and-covid-19-pandemics
#10
JOURNAL ARTICLE
Yusuke Okubo, Kazuhiro Uda
BACKGROUND: This study explored factors associated with testing and diagnoses for children with COVID-19 at the hospital level and investigated whether the capacity of testing and diagnoses during the 2009 influenza pandemic was associated with that during COVID-19 pandemic. METHODS: In this observational study, we analyzed data obtained from the Japan Medical Data Center database, comprising 4906 medical facilities and 1.7 million infectious disease-related visits among children aged <20 years in 2020-2021...
March 15, 2024: Respiratory Investigation
https://read.qxmd.com/read/38492269/empirical-investigation-of-passive-blood-drop-trajectory-and-first-point-of-contact-on-inclined-surfaces
#11
JOURNAL ARTICLE
Kara Cseh, Eugene Liscio
The first point of contact between a spherical blood drop and a surface is related to the angle between the trajectory of the blood drop and the surface being struck. This angle is often referred to as the impact angle which can be estimated by knowing the width and length of the resultant elliptical bloodstain. Most software programs dedicated to area of origin analysis indicate the location of the backtracked bloodstain trajectory to be at the geometric centre or at the tip of the bloodstain ellipse. However, it is unknown how the first point of contact and the blood drop trajectory (here defined as the locus of the centre of mass of the drop as it travels) are related empirically...
March 11, 2024: Forensic Science International
https://read.qxmd.com/read/38492168/residents-satisfaction-and-suggestions-to-improve-nephrology-residency-in-italy-and-comparison-with-the-organization-in-other-european-countries
#12
JOURNAL ARTICLE
Adolfo Marco Perrotta, Silverio Rotondi, Maria Amicone, Irene Cirella, Rossella Siligato, Simone Fontana, Carmen Sivo, Anna Rita Vestri, Giovanni Gambaro, Giorgina Barbara Piccoli, Sandro Mazzaferro
BACKGROUND: In Italy, nephrology residency is available in twenty-one nephrology schools, each with its own strengths and weaknesses. The present study is aimed at exploring the residents' satisfaction with their training programs. METHODS: Between April 20th and May 19th, 2021, a questionnaire on residency satisfaction consisting of 49 items was sent to 586 residents and 175 recently certified specialists (qualified to practice as nephrologists in 2019 and 2020), with a response rate of 81% and 51%, respectively...
March 16, 2024: Journal of Nephrology
https://read.qxmd.com/read/38492150/eating-disorders-and-covid-19-different-or-just-more
#13
JOURNAL ARTICLE
Cathal Rafferty, Angela O'Donnell, Sally Campbell, Bohan Sun, Jenny King, Zeinab Ali, Diarmuid Lynch, Elizabeth Barrett, Sarah Richardson, Michelle Clifford, Fiona McNicholas
BACKGROUND: COVID-19 saw an increase in child mental health presentations internationally. Clinicians analogised the exponential increase in anorexia nervosa to a 'tsunami' or 'outbreak', raising parallel concerns regarding medical and psychological risks (Marsh in The Guardian, 2021; Leask in NZ Herald, 2021; Monteleone et al. in Eat Weight Disord 26(8):2443-2452, 2021) . It is unclear whether Ireland emulated this picture of increased referrals with increased medical compromise...
March 16, 2024: Irish Journal of Medical Science
https://read.qxmd.com/read/38491995/public-versus-private-care-in-the-military-health-system-evidence-from-low-back-pain-patients
#14
JOURNAL ARTICLE
Christopher G Leggett, Rachel O Schmidt, Jonathan Skinner, Jon D Lurie, William Patrick Luan
INTRODUCTION: There is a longstanding debate about whether health care is more efficiently provided by the public or private sector. The debate is particularly relevant to the Military Health System (MHS), which delivers care through a combination of publicly funded federal facilities and privately contracted providers. This study compares outcomes, treatments, and costs for MHS patients obtaining care for low back pain (LBP) from public versus private providers. MATERIALS AND METHODS: A retrospective cohort study was completed using TRICARE Prime claims data from April 2015 to December 2018...
March 16, 2024: Military Medicine
https://read.qxmd.com/read/38491958/subjective-caregiver-burden-and-coping-in-family-carers-of-dependent-adults-and-older-people-a-systematic-review-and-meta-analysis
#15
REVIEW
Juan Carlos Muñoz-Cruz, Catalina López-Martínez, Vasiliki Orgeta, Rafael Del-Pino-Casado
Subjective caregiver burden is highly prevalent in family caregivers. Despite several studies investigating the relationship between subjective caregiver burden and coping strategies, results remain inconsistent. The aim of our study was to systematically review current literature on the relationship between subjective caregiver burden and coping in family carers of dependent adults and older people. A secondary objective was to analyse possible sources of heterogeneity in the estimated effect. The study design was a systematic review with meta-analysis following Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA) guidelines...
March 16, 2024: Stress and Health: Journal of the International Society for the Investigation of Stress
https://read.qxmd.com/read/38491899/river-water-pollution-in-lebanon-the-country-s-most-underestimated-public-health-challenge
#16
JOURNAL ARTICLE
Carolla El Chamieh, Claudia El Haddad, Khaled El Khatib, Edmond Jalkh, Victoria Al Karaki, Jana Zeineddine, Antoine Assaf, Tania Harb, Elie Bou Sanayeh
BACKGROUND: Due to the several interconnected crises that Lebanon has been facing for the past 4 years, many important social and environmental issues have been overlooked until more "pressing" ones are dealt with. Consequently, water pollution in Lebanon continues to worsen. AIM: This study aimed to describe the microbiological and chemical properties of the 10 main rivers in Lebanon and to assess their suitability for irrigation, while exploring some of the solutions to the problem...
February 25, 2024: Eastern Mediterranean Health Journal
https://read.qxmd.com/read/38491851/perceptions-of-clinical-experience-and-scientific-evidence-in-medical-decision-making-a-survey-of-a-stratified-random-sample-of-swedish-health-care-professionals
#17
JOURNAL ARTICLE
Barry Dewitt, Johannes Persson, Annika Wallin
BACKGROUND: Evidence-based medicine recognizes that clinical expertise gained through experience is essential to good medical practice. However, it is not known what beliefs clinicians hold about how personal clinical experience and scientific knowledge contribute to their clinical decision making and how those beliefs vary between professions, which themselves vary along relevant characteristics, such as their evidence base. DESIGN: We investigate how years in the profession influence health care professionals' beliefs about science and their clinical experience through surveys administered to random samples of Swedish physicians, nurses, occupational therapists, dentists, and dental hygienists...
March 16, 2024: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://read.qxmd.com/read/38491833/ultrasound-guided-percutaneous-high-frequency-irreversible-electroporation-in-porcine-livers-using-four-electrode-needles-a-feasibility-and-safety-study
#18
JOURNAL ARTICLE
Chang-Tian Li, Guo-Dong Zhao, Wen-Bo Zou, Zhen-Hua Zhang, Yi Zhao, Rong Liu
BACKGROUND: Malignant liver tumors seriously endanger human health. Among different therapeutic approaches, high-frequency irreversible electroporation (H-FIRE) is a recently emerging tumor ablation technique. The objective of this study was to evaluate the feasibility and safety of ultrasound-guided percutaneous H-FIRE using four electrode needles in porcine livers. METHODS: Twelve experimental pigs underwent percutaneous H-FIRE ablation using a compound steep-pulse therapeutic device...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38491830/common-data-elements-for-arthrogryposis-multiplex-congenita-an-international-framework
#19
JOURNAL ARTICLE
Shahrzad Nematollahi, Klaus Dieterich, Isabel Filges, Johanna I P De Vries, Harold Van Bosse, Daniel Natera-De Benito, Judith G Hall, Bonita Sawatzky, Tanya Bedard, Victoria Castillo Sanchez, Carolina Navalon-Martinez, Tony Pan, Coleman Hilton, Noémi Dahan-Oliel
AIM: To facilitate multisite studies and international clinical research, this study aimed to identify consensus-based, standardized common data elements (CDEs) for arthrogryposis multiplex congenita (AMC). METHOD: A mixed-methods study comprising of several focus group discussions and three rounds of modified Delphi surveys to achieve consensus using two tiered-rating scales were conducted. RESULTS: Overall, 45 clinical experts and adults with lived experience (including 12 members of an AMC consortium) participated in this study from 11 countries in North America, Europe, and Australia...
March 16, 2024: Developmental Medicine and Child Neurology
https://read.qxmd.com/read/38491738/engaging-patients-in-designing-a-transmural-allied-health-pathway-a-qualitative-exploration-of-hospital-to-home-transitions
#20
JOURNAL ARTICLE
Juul W M van Grootel, Romain J Collet, Mel E Major, Suzanne Wiertsema, Hanneke van Dongen, Marike van der Leeden, Edwin Geleijn, Raymond Ostelo, Marike van der Schaaf
INTRODUCTION: The transition from hospital to home is often suboptimal, resulting in patients not receiving the necessary allied healthcare after discharge. This may, in turn, lead to delayed recovery, a higher number of readmissions, more emergency department visits and an increase in mortality and healthcare costs. This study aimed to gain insight into patients' experiences, perceptions, and needs regarding hospital-to-home transition, focusing on allied healthcare as a first step towards the development of a transitional integrated allied healthcare pathway for patients with complex care needs after hospital discharge...
April 2024: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
keyword
keyword
38155
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.