Ana Beatriz Proença, Gabriela Rodrigues Medeiros, Guilherme Dos Santos Reis, Luiza da França Losito, Luiza Mazzali Ferraz, Thereza Cristina Lonzetti Bargut, Nícia Pedreira Soares, Beatriz Alexandre-Santos, Maria Jose Campagnole-Santos, D'Angelo Carlo Magliano, Antonio Claudio Lucas da Nobrega, Robson Augusto Souza Santos, Eliete Dalla Corte Frantz
The renin-angiotensin system (RAS) is an endocrine system composed of two main axes: the classical and the counterregulatory, very often displaying opposing effects. The classical axis, primarily mediated by angiotensin receptors type 1 (AT1R), is linked to obesity-associated metabolic effects. On the other hand, the counterregulatory axis appears to exert antiobesity effects through the activation of two receptors, the G protein-coupled receptor (MasR) and Mas-related receptor type D (MrgD). The local RAS in adipose organ has prompted extensive research into white adipose tissue and brown adipose tissue (BAT), with a key role in regulating the cellular and metabolic plasticity of these tissues...
April 5, 2024: Journal of Cellular Physiology