keyword
MENU ▼
Read by QxMD icon Read
search

Lipolysis

keyword
https://www.readbyqxmd.com/read/29329795/omega-3-fatty-acids-and-adipose-tissue-biology
#1
REVIEW
Ondrej Kuda, Martin Rossmeisl, Jan Kopecky
This review provides evidence for the importance of white and brown adipose tissue (i.e. WAT and BAT) function for the maintenance of healthy metabolic phenotype and its preservation in response to omega-3 polyunsaturated fatty acids (omega-3 PUFA), namely in the context of diseased states linked to aberrant accumulation of body fat, systemic low-grade inflammation, dyslipidemia and insulin resistance. More specifically, the review deals with (i) the concept of immunometabolism, i.e. how adipose-resident immune cells and adipocytes affect each other and define the immune-metabolic interface; and (ii) the characteristic features of "healthy adipocytes" in WAT, which are relatively small fat cells endowed with a high capacity for mitochondrial oxidative phosphorylation, triacylglycerol/fatty acid (TAG/FA) cycling and de novo lipogenesis (DNL)...
January 9, 2018: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/29327704/emerging-nonmetabolic-functions-of-skin-fat
#2
REVIEW
Christian F Guerrero-Juarez, Maksim V Plikus
Although the major white adipose depots evolved primarily to store energy, secrete hormones and thermo-insulate the body, multiple secondary depots developed additional specialized and unconventional functions. Unlike any other fat tissue, dermal white adipose tissue (dWAT) evolved a large repertoire of novel features that are central to skin physiology, which we discuss in this Review. dWAT exists in close proximity to hair follicles, the principal appendages of the skin that periodically grow new hairs. Responding to multiple hair-derived signals, dWAT becomes closely connected to cycling hair follicles and periodically cycles itself...
January 12, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29325553/sitagliptin-improved-glucose-assimilation-in-detriment-of-fatty-acid-utilization-in-experimental-type-ii-diabetes-role-of-glp-1-isoforms-in-glut4-receptor-trafficking
#3
E Ramírez, B Picatoste, A González-Bris, M Oteo, F Cruz, A Caro-Vadillo, J Egido, J Tuñón, M A Morcillo, Ó Lorenzo
BACKGROUND: The distribution of glucose and fatty-acid transporters in the heart is crucial for energy consecution and myocardial function. In this sense, the glucagon-like peptide-1 (GLP-1) enhancer, sitagliptin, improves glucose homeostasis but it could also trigger direct cardioprotective actions, including regulation of energy substrate utilization. METHODS: Type-II diabetic GK (Goto-Kakizaki), sitagliptin-treated GK (10 mg/kg/day) and wistar rats (n = 10, each) underwent echocardiographic evaluation, and positron emission tomography scanning for [18F]-2-fluoro-2-deoxy-D-glucose (18FDG)...
January 11, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29323242/adipose-specific-lipin1-overexpression-in-mice-protects-against-alcohol-induced-liver-injury
#4
Wenliang Zhang, Wei Zhong, Qian Sun, Xinguo Sun, Zhanxiang Zhou
Excessive fatty acid release from the white adipose tissue (WAT) contributes to the development of alcoholic liver disease (ALD). Lipin1 (LPIN1), as a co-regulator of DNA-bound transcription factors and a phosphatidic acid (PA) phosphatase (PAP) enzyme that dephosphorylates PA to form diacylglycerol (DAG), is dramatically reduced by alcohol in the WAT. This study aimed at determining the role of adipose LPIN1 in alcohol-induced lipodystrophy and the development of ALD. Transgenic mice overexpressing LPIN1 in adipose tissue (LPIN1-Tg) and wild type (WT) mice were fed a Lieber-DeCarli alcohol or isocaloric maltose dextrin control liquid diet for 8 weeks...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320510/adipose-tissue-atgl-modifies-the-cardiac-lipidome-in-pressure-overload-induced-left-ventricular-failure
#5
Janek Salatzki, Anna Foryst-Ludwig, Kajetan Bentele, Annelie Blumrich, Elia Smeir, Zsofia Ban, Sarah Brix, Jana Grune, Niklas Beyhoff, Robert Klopfleisch, Sebastian Dunst, Michal A Surma, Christian Klose, Michael Rothe, Frank R Heinzel, Alexander Krannich, Erin E Kershaw, Dieter Beule, P Christian Schulze, Nikolaus Marx, Ulrich Kintscher
Adipose tissue lipolysis occurs during the development of heart failure as a consequence of chronic adrenergic stimulation. However, the impact of enhanced adipose triacylglycerol hydrolysis mediated by adipose triglyceride lipase (ATGL) on cardiac function is unclear. To investigate the role of adipose tissue lipolysis during heart failure, we generated mice with tissue-specific deletion of ATGL (atATGL-KO). atATGL-KO mice were subjected to transverse aortic constriction (TAC) to induce pressure-mediated cardiac failure...
January 10, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29314036/multilayer-emulsions-as-a-strategy-for-linseed-oil-and-alpha-lipoic-acid-micro-encapsulation-study-on-preparation-and-in-vitro-characterization
#6
Juan Huang, Qiang Wang, Tong Li, Nan Xia, Qiang Xia
BACKGROUND: Linseed oil and alpha-lipoic acid are bioactive ingredients, which play an important role in human's nutrition and health. However, their application in functional foods is limited because of their instabilities and poor solubilities in hydrophilic matrices. Multilayer emulsions are particularly useful to protect encapsulated bioactive ingredients. The aim of this study was to fabricate multilayer emulsions by high pressure homogenization method to encapsulate linseed oil and alpha-lipoic acid simultaneously...
January 4, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29301491/pancreatic-panniculitis-the-bright-side-of-the-moon-in-solid-cancer-patients
#7
Elena Guanziroli, Antonella Colombo, Antonella Coggi, Raffaele Gianotti, Angelo Valerio Marzano
BACKGROUND: Pancreatic panniculitis is a rare complication of pancreas disorders occurring in 0.3-3% of patients, most often accompanied by the pancreatic acinar carcinoma. It presents multiple, painful, deep, ill-defined, red-brown, migratory nodules and plaques of hard elastic consistency; often ulcerated and typically located on the lower proximal and distal extremities. The pathogenesis is not fully understood, but it is thought to result from lipolysis and fat necrosis with secondary tissue inflammation induced by pancreatic enzymes...
January 4, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29300344/implications-of-aquaglyceroporin-7-in-energy-metabolism
#8
REVIEW
Francesco Maria Iena, Janne Lebeck
The aquaglyceroporin AQP7 is a pore-forming transmembrane protein that facilitates the transport of glycerol across cell membranes. Glycerol is utilized both in carbohydrate and lipid metabolism. It is primarily stored in white adipose tissue as part of the triglyceride molecules. During states with increased lipolysis, such as fasting and diabetes, glycerol is released from adipose tissue and metabolized in other tissues. AQP7 is expressed in adipose tissue where it facilitates the efflux of glycerol, and AQP7 deficiency has been linked to increased glycerol kinase activity and triglyceride accumulation in adipose tissue, leading to obesity and secondary development of insulin resistance...
January 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29297209/monitoring-of-temperature-mediated-phase-transitions-of-adipose-tissue-by-combined-optical-coherence-tomography-and-abbe-refractometry
#9
Irina Y Yanina, Alexey P Popov, Alexander V Bykov, Igor V Meglinski, Valery V Tuchin
Observation of temperature-mediated phase transitions between lipid components of the adipose tissues has been performed by combined use of the Abbe refractometry and optical coherence tomography. The phase transitions of the lipid components were clearly observed in the range of temperatures from 24°C to 60°C, and assessed by quantitatively monitoring the changes of the refractive index of 1- to 2-mm-thick porcine fat tissue slices. The developed approach has a great potential as an alternative method for obtaining accurate information on the processes occurring during thermal lipolysis...
January 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29295869/macrophage-activation-marker-scd163-correlates-with-accelerated-lipolysis-following-lps-exposure-a-human-randomised-clinical-trial
#10
Nikolaj Rittig, Mads Svart, Niels Jessen, Niels Møller, Holger J Møller, Henning Grønbæk
BACKGROUND: Macrophage activation determined by levels of soluble sCD163 is associated with obesity, insulin resistance, diabetes mellitus type 2 (DM2) and non-alcoholic fatty liver disease (NAFLD). This suggests that macrophage activation is involved in the pathogenesis of conditions is characterised by adaptions in the lipid metabolism. Since sCD163 is shed to serum by inflammatory signals including lipopolysaccharides (LPS, endotoxin), we investigated sCD163 and correlations with lipid metabolism following LPS exposure...
January 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29291086/curcumin-improves-glycolipid-metabolism-through-regulating-peroxisome-proliferator-activated-receptor-%C3%AE-signalling-pathway-in-high-fat-diet-induced-obese-mice-and-3t3-l1-adipocytes
#11
Yanyun Pan, Dandan Zhao, Na Yu, Tian An, Jianan Miao, Fangfang Mo, Yujie Gu, Dongwei Zhang, Sihua Gao, Guangjian Jiang
Curcumin is an active component derived from Curcuma longa L. which is a traditional Chinese medicine that is widely used for treating metabolic diseases through regulating different molecular pathways. Here, in this study, we aimed to comprehensively investigate the effects of curcumin on glycolipid metabolism in vivo and in vitro and then determine the underlying mechanism. Male C57BL/6 J obese mice and 3T3-L1 adipocytes were used for in vivo and in vitro study, respectively. Our results demonstrated that treatment with curcumin for eight weeks decreased body weight, fat mass and serum lipid profiles...
November 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29289610/body-composition-serum-lipid-levels-and-transcriptomic-characterization-in-the-adipose-tissue-of-male-pigs-in-response-to-sex-hormone-deficiency
#12
Yuchang Yao, Hongying Ma, Keliang Wu, Yonggang Shao, Wenpeng Han, Zhaowei Cai, Ningying Xu, Meiyu Qi, Chunjiang Zhao, Changxin Wu
It is known that the male hypogonadism plays an important role in regulating adipose metabolism. In the present study, fifteen pairs of full male sibs were divided into a castrated group and an intact group with a paired experiment design. The pigs were slaughtered at an age of 175days. The carcass characteristics and fat deposit of the studied animal were measured, and the hormone and serum lipid levels of the peripheral blood samples were determined, and the differentially expressed genes of the back fat between the two groups were screened with porcine genome array...
December 28, 2017: Gene
https://www.readbyqxmd.com/read/29288805/the-ability-of-two-in-vitro-lipolysis-models-reflecting-the-human-and-rat-gastro-intestinal-conditions-to-predict-the-in-vivo-performance-of-snedds-dosing-regimens
#13
Scheyla D V S Siqueira, Malak Al Sawaf, Kirsten Gräeser, Huiling Mu, Anette Müllertz, Thomas Rades
In this work, the influence of drug load and physical state of R3040 in self-nanoemulsifying drug delivery systems (SNEDDS) on R3040 absorption in rats was assessed. Furthermore, an in vitro lipolysis model simulating rat conditions (rat lipolysis model) was compared to a human lipolysis model in regard to the prediction of the in vivo data. The formulations were SNEDDS 80 %, containing R3040 at 80 % of its equilibrium solubility in SNEDDS (Seq); super-SNEDDS solution with R3040 supersaturated at 200 % Seq; super-SNEDDS suspension containing R3040 at 200 % Seq; Chasing principle (drug-free SNEDDS followed by R3040 aqueous suspension) and R3040 aqueous suspension...
December 27, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29288687/distinctive-effects-of-licarin-a-on-lipolysis-mediated-by-pka-and-on-formation-of-brown-adipocytes-from-c3h10t1-2-mesenchymal-stem-cells
#14
Dahyeon Yoon, Khan Mohammad Imran, Yong-Sik Kim
Obesity increases with the positive energy imbalance and correlates with increased risks for metabolic diseases. Promotion of white adipose tissue beiging has received considerable attention due to possible usefulness for preventing obesity and the comorbidities. Licarin A (LA) is a compound derived from Mexican medicinal plant Aristolochia taliscana. Here, we report that LA stimulates the development of brown-like and beige-like adipocytes from C3H10T1/2 mesenchymal stem cells with phenotypic shifts to formation of smaller lipid droplets...
December 27, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29282281/unbalanced-lipolysis-results-in-lipotoxicity-and-mitochondrial-damage-in-peroxisome-deficient-pex19-mutants
#15
Margret H Bülow, Christian Wingen, Deniz Senyilmaz, Dominic Gosejacob, Mariangela Sociale, Reinhard Bauer, Heike Schulze, Konrad Sandhoff, Aurelio A Teleman, Michael Hoch, Julia Sellin
Inherited Peroxisomal biogenesis disorders (PBDs) are characterized by the absence of functional peroxisomes. They are caused by mutations of peroxisomal biogenesis factors encoded by PEX genes, and result in childhood lethality. Due to the many metabolic functions fulfilled by peroxisomes, PBD pathology is complex and incompletely understood. Besides accumulation of peroxisomal educts (like very long chain fatty acids (VLCFA) or branched chain fatty acids) and lack of products (like bile acids or plasmalogens), many peroxisomal defects lead to detrimental mitochondrial abnormalities for unknown reasons...
December 27, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29280746/congenital-hyperinsulinism-diagnosis-and-treatment-update
#16
Hüseyin Demirbilek, Khalid Hussain
Pancreatic β-cells are finely tuned to secrete insulin so that plasma glucose levels are maintained within a narrow physiological range (3.5-5.5 mmol/L). Hyperinsulinaemic hypoglycaemia (HH) is the inappropriate seretion of insulin in the presence of low plasma glucose levels and leads to severe and persistent hypoglycaemia in neonates and children. Mutations in 12 different key genes (ABCC8, KCNJ11, GLUD1, GCK, HADH, SLC16A1, UCP2, HNF4A, HNF1A, HK1, PGM1 and PMM2) that are involved in the regulation of insulin secretion from pancreatic β-cells have been described to be responsible for the underlying molecular mechanisms leading to congenital HH...
December 27, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29274966/fetuin-a-a-negative-acute-phase-protein-linked-to-adipose-tissue-function-in-periparturient-dairy-cows
#17
Clarissa Strieder-Barboza, Jonas de Souza, William Raphael, Adam L Lock, G Andres Contreras
Fetuin-A (FetA) is a free fatty acid transporter and an acute-phase protein that enhances cellular lipid uptake and lipogenesis. In nonruminants, FetA is involved in lipid-induced inflammation. Despite FetA importance in lipid metabolism and inflammation, its expression and dynamics in adipose tissue (AT) of dairy cows are unknown. The objectives of this study were to (1) determine serum and AT FetA dynamics over the periparturient period and in mid-lactation cows in negative energy balance (NEB) after a feed restriction protocol and (2) characterize how an inflammatory challenge affects adipocyte FetA expression...
December 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29274235/the-role-of-breakfast-in-adipose-tissue-biology
#18
Jun Yoshino
Adipose tissue has traditionally been viewed as an energy sink that can store the excess calorie in the form of triglycerides and then release non-esterified fatty acids (NEFA) and glycerol into the blood circulation during lipolysis of triglyceride. This article is protected by copyright. All rights reserved.
December 23, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29249968/purinergic-receptors-in-adipose-tissue-as-potential-targets-in-metabolic-disorders
#19
REVIEW
Marco Tozzi, Ivana Novak
Extracellular nucleosides and nucleotides, such as adenosine and adenosine triphosphate (ATP), are involved in many physiological and pathological processes in adipose tissue (AT). It is becoming accepted that, in addition to the well-established sympathetic and hormonal system, purinergic receptors contribute significantly to regulation of adipocyte functions. Several receptor subtypes for both adenosine (P1) and ATP (P2X and P2Y) have been characterized in white adipocytes (WA) and brown adipocytes (BA). The effects mediated by adenosine and ATP on adipocytes are multiple and often differing, depending on specific receptors activated...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29248609/size-characterization-of-lipid-based-self-emulsifying-pharmaceutical-excipients-during-lipolysis-using-taylor-dispersion-analysis-with-fluorescence-detection
#20
Joseph Chamieh, Habib Merdassi, Jean-Christophe Rossi, Vincent Jannin, Frédéric Demarne, Hervé Cottet
Self-emulsifying drug delivery systems based on lipids have gained in interest in recent years due to their capacity to enhance the bioavailability of poorly water soluble drugs. Their oral intake suggests that they will be in contact with gastric and pancreatic enzymes during their passage through the gastrointestinal tract. The study of the evolution of such systems in the presence of enzymes is thus essential to develop better drug delivery vehicles. In this work, the lipolysis of two lipid based self-emulsifying drug delivery systems, Labrasol® and Gelucire® 44/14 by pancreatic enzymes and under conditions mimicking the gastrointestinal tract are presented...
December 14, 2017: International Journal of Pharmaceutics
keyword
keyword
38136
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"