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https://www.readbyqxmd.com/read/28216517/simultaneous-resection-for-colorectal-cancer-with-synchronous-liver-metastases-is-a-safe-procedure-outcomes-at-a-single-center-in-turkey
#1
Ender Dulundu, Wafi Attaallah, Metin Tilki, Cumhur Yegen, Safak Coskun, Mumin Coskun, Aylin Erdim, Eda Tanrikulu, Samet Yardimci, Omer Gunal
The optimal surgical strategy for treating colorectal cancer with synchronous liver metastases is subject to debate. The current study sought to evaluate the outcomes of simultaneous colorectal cancer and liver metastases resection in a single center. Prospectively collected data on all patients with synchronous colorectal liver metastases who underwent simultaneous resection with curative intent were analyzed retrospectively. Patient outcomes were compared depending on the primary tumor location and type of liver resection (major or minor)...
February 17, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28213843/effect-of-biofeedback-therapy-on-anorectal-physiological-parameters-among-patients-with-fecal-evacuation-disorder
#2
Abhai Verma, Asha Misra, Uday C Ghoshal
BACKGROUND: Though biofeedback therapy is often effective in patients with fecal evacuation disorder (FED), a common cause of chronic constipation (CC) in tertiary practice, data on anorectal physiological parameters following it are scanty. METHODS: Consecutive patients with FED with CC diagnosed by abnormalities in at least two of the three tests (anorectal manometry, defecography, and balloon expulsion test [BET]) undergoing biofeedback (two sessions per day, 30 min each, for 2 weeks) during a 3-year period were analyzed...
February 18, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28194176/clinicopathological-features-and-prognostic-factors-of-colorectal-neuroendocrine-neoplasms
#3
Mengjie Jiang, Yinuo Tan, Xiaofen Li, Jianfei Fu, Hanguang Hu, Xianyun Ye, Ying Cao, Jinghong Xu, Ying Yuan
Background. Limited research is available regarding colorectal NENs and the prognostic factors remain controversial. Materials and Methods. A total of 68 patients with colorectal NENs were studied retrospectively. Clinical characteristics and prognosis between colonic and rectal NENs were compared. The Cox regression models were used to evaluate the predictive capacity. Results. Of the 68 colorectal NENs patients, 43 (63.2%) had rectal NENs, and 25 (36.8%) had colonic NENs. Compared with rectal NENs, colonic NENs more frequently exhibited larger tumor size (P < 0...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28156538/variation-in-utilization-of-palliative-surgery-in-patients-with-metastatic-colorectal-cancer
#4
Hari Nathan, Scott E Regenbogen, Samantha Hendren, Arden M Morris, Pasithorn Amy Suwanabol
: 120 Background: Twenty-five percent of patients with colorectal cancer will present with unresectable disease. Palliative surgery has been shown to improve symptom control and improve patient satisfaction as well as demonstrate improved cost and decreased healthcare utilization. However, it is unclear what factors influence use. We sought to determine patient and hospital factors associated with palliative surgery use in advanced colorectal cancers. METHODS: Using the National Cancer Data Base (NCDB) Participant User File from 2006 to 2012, 162,967 patients with metastatic colorectal cancer were identified...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152894/engaging-managing-physicians-in-clinical-staging-prior-to-the-initiation-of-cancer-treatment
#5
Carol Huibregtse, Marija Bjegovich-Weidman, James L Weese
: 143 Background: Managing physicians (medical oncologist, radiation oncologist, surgeons) have a responsibility to clinically stage patients prior to the initiation of cancer treatment. Clinical staging not only directs the treatment plan, but identifies appropriate clinical trials and estimates prognosis. We sought to determine whether engagement of managing physicians would result in increased clinical staging for various types of cancer. METHODS: Baseline data on clinical staging for breast, colorectal (colon, rectal, anal, rectosigmoid junction)*, thoracic (lung esophageal)†, genitourinary (prostate, penis, testes)‡, and pancreatic primary cancers were obtained...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28150422/successful-restoration-of-fecal-continence-using-sacral-nerve-stimulation-following-chemoradiation-and-transanal-excision-of-an-anal-melanoma-with-partial-internal-anal-sphincter-resection-a-case-report
#6
Tyler Cameron Tolopka, Craig A Messick
OBJECTIVE: This case report provides evidence for our hypothesis that use of a sacral nerve stimulator may be considered in patients with fecal incontinence (FI) following chemoradiation and transanal operations in the setting of cancer including partial internal sphincter resections. MATERIALS AND METHODS: A 57-year-old female with a history of anal melanoma was treated with neoadjuvant chemoradiation followed by wide local, transanal tumor excision with partial internal anal sphincter resection that resulted in ≥2 full fecal incontinent episodes/week with gas, liquid, and solid stool leakage ≥10/day requiring pad changes...
February 1, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28145532/computational-imaging-reveals-shape-differences-between-normal-and-malignant-prostates-on-mri
#7
Mirabela Rusu, Andrei S Purysko, Sadhna Verma, Jonathan Kiechle, Jay Gollamudi, Soumya Ghose, Karin Herrmann, Vikas Gulani, Raj Paspulati, Lee Ponsky, Maret Böhm, Anne-Maree Haynes, Daniel Moses, Ron Shnier, Warick Delprado, James Thompson, Phillip Stricker, Anant Madabhushi
We seek to characterize differences in the shape of the prostate and the central gland (combined central and transitional zones) between men with biopsy confirmed prostate cancer and men who were identified as not having prostate cancer either on account of a negative biopsy or had pelvic imaging done for a non-prostate malignancy. T2w MRI from 70 men were acquired at three institutions. The cancer positive group (PCa+) comprised 35 biopsy positive (Bx+) subjects from three institutions (Gleason scores: 6-9, Stage: T1-T3)...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28141846/changes-in-bacterial-community-composition-of-escherichia-coli-o157-h7-super-shedder-cattle-occur-in-the-lower-intestine
#8
Rahat Zaheer, Eric Dugat-Bony, Devon Holman, Elodie Cousteix, Yong Xu, Krysty Munns, Lorna J Selinger, Rutn Barbieri, Trevor Alexander, Tim A McAllister, L Brent Selinger
Escherichia coli O157:H7 is a foodborne pathogen that colonizes ruminants. Cattle are considered the primary reservoir of E. coli O157:H7 with super-shedders, defined as individuals excreting > 104 E. coli O157:H7 CFU g-1 feces. The mechanisms leading to the super-shedding condition are largely unknown. Here, we used 16S rRNA gene pyrosequencing to examine the composition of the fecal bacterial community in order to investigate changes in the bacterial microbiota at several locations along the digestive tract (from the duodenum to the rectal-anal junction) in 5 steers previously identified as super-shedders and 5 non-shedders...
2017: PloS One
https://www.readbyqxmd.com/read/28133302/-two-cases-of-locally-recurrent-rectal-cancer-after-intersphincteric-resection-that-were-controlled-with-a-combination-of-chemoradiotherapy-and-abdominoperineal-resection
#9
Yasuhiro Komatsu, Hitoshi Idani, Kazutaka Takahashi, Naoki Mimura, Toshihiro Ogawa, Soichiro Miyake, Michihiro Ishida, Daisuke Satoh, Yasuhiro Choda, Daisuke Sumitani, Masao Harano, Hiroyoshi Matsukawa, Yasutomo Ojima, Shigehiro Shiozaki, Masazumi Okajima
We report 2 cases of locally recurrent rectal cancer after intersphincteric resection(ISR)that were controlled with a combination of chemoradiotherapy and abdominoperineal resection(APR). In Case 1, we performed preoperative chemoradiotherapy( TS-1 plus RT 45 Gy)and APR for the local recurrence of ISR. On pathology, viable neoplastic cells were noted. In Case 2, we performed preoperative chemotherapy(Bmab plus mFOLFOX6)and APR for the local recurrence of ISR. On pathology, no viable neoplastic cells were noted...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133138/-case-of-laparoscopic-sigmoidectomy-for-a-patient-with-persistent-descending-mesocolon
#10
Shu Arai, Yoji Nishimura, Shinsuke Kazama, Yusuke Nishizawa, Hideki Ishikawa, Yoshihiro Mori, Takashi Takenoya, Michitoshi Takano
A 65-year-old man with bloody stools was diagnosed with sigmoid colon cancer on colonoscopy. A preoperative barium enema and a computed tomography colonography scan showed a medial displacement of his descending colon. The preoperative clinical diagnosis was stage cT1 colon cancer, N0, M0, cStage I . Laparoscopic sigmoidectomy was performed. We found adhesions between the descending colon mesentery and the pelvic wall, and noted that the descending colon was not fused with the retroperitoneum and was shifted to the midline...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28124535/does-mri-help-in-the-pre-operative-evaluation-of-pelvic-fracture-urethral-distraction-defect-a-pilot-study
#11
Rajadoss Muthukrishna Pandian, Nirmal Thampi John, Anu Eapen, B Antonisamy, Antony Devasia, Nitin Kekre
OBJECTIVES: To study the usefulness of MRI in preoperative evaluation of PFUDD. Can MRI provide additional information on urethral distraction defect (UDD) and cause of erectile dysfunction (ED)? MATERIALS AND METHODS: In this prospective study, consecutive male patients presenting with PFUDD were included from Feb 2011 till Dec 2012. Those with traumatic spinal cord injury and pre-existing ED were excluded. Patients were assessed using IIEF questionnaire, retrograde urethrogram and micturating cystourethrogram (RGU+MCU) and MRI pelvis...
January 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28119867/pneumoretroperitoneum-pneumomediastinum-subcutaneous-emphysema-after-a-rectal-endoscopic-mucosal-resection
#12
Hee Cheul Jung, Hyun Jin Kim, Sung Bok Ji, Jun Hyeong Cho, Ji Hye Kwak, Chang Min Lee, Wan Soo Kim, Jin Ju Kim, Jae Min Lee, Sang Su Lee
An endoscopic mucosal resection (EMR) is an effective and safe therapeutic technique for treating a patient with a laterally-spreading tumor (LST). Colonoscopic-procedure-related complications are noted to be about 2.8% worldwide, and a perforation is the most common. Most colon perforations cause pneumoperitoneum. However, a perforation within the retroperitoneal portion of the colon (rectum and some of sigmoid colon) may cause an extraperitoneal perforation, and the leaking free air may induce pneumoretroperitoneum, pneumomediastinum, and subcutaneous emphysema, depending on the amount of discharged air...
December 2016: Annals of Coloproctology
https://www.readbyqxmd.com/read/28116474/prenatal-magnetic-resonance-and-ultrasonographic-findings-in-small-bowel-obstruction-imaging-clues-and-postnatal-outcomes
#13
Eva I Rubio, Anna R Blask, Andrea T Badillo, Dorothy I Bulas
BACKGROUND: Prenatal small-bowel obstruction can result from single or multiple atresias, and it can be an isolated abnormality or part of a syndrome. It is sometimes the first manifestation of cystic fibrosis. Accurate prediction of the level of obstruction and length of bowel affected can be difficult, presenting a challenge for counseling families and planning perinatal management. OBJECTIVE: To review the prenatal US and MRI findings of small-bowel obstruction and to assess whether fetal MRI adds information that could improve prenatal counseling and perinatal management...
January 23, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28091843/the-incidence-of-post-colonoscopy-colorectal-cancer-a-retrospective-long-term-cohort-study-using-a-colonoscopy-database
#14
Ayako Nakada, Ryota Niikura, Atsuo Yamada, Shuntaro Yoshida, Yoshihiro Hirata, Kazuhiko Koike
PURPOSE: The cumulative incidence of post-colonoscopy colorectal cancer remains unclear. Our aims were to estimate the incidence of and identify risk factors associated with post-colonoscopy colorectal cancer. METHODS: We conducted a retrospective cohort study using the colonoscopy database of the Department of Gastroenterology, the University of Tokyo Hospital Records from1995-2012. A cohort of 2544 patients, who received multiple colonoscopies without colorectal cancer findings at first colonoscopy, was selected...
January 14, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28048880/su-f-r-34-quantitative-perfusion-measurement-in-rectal-cancer-using-three-different-pharmacokinetic-models-implications-for-prospective-study-design
#15
K Nie, T Mao, L Shi, N Yue, S Jabbour, S Kim, X Hu, L Qian, X Sun, T Niu
PURPOSE: To compare three different pharmacokinetic models for analysis of dynamic-contrast-enhanced (DCE)-CT data with respect to different acquisition times and location of region of interest. METHODS: Eight rectal cancer patients with pre-treatment DCE-CTs were included. The dynamic sequence started 4-10seconds(s) after the injection of contrast agent. The scan included a 110s acquisition with intervals of 40×1s+15×3s+4×6s. An experienced oncologist outlined the tumor region...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039104/rectal-carriage-of-extended-spectrum-%C3%AE-lactamase-and-carbapenemase-producing-enterobacteriaceae-among-hospitalised-neonates-in-a-neonatal-intensive-care-unit-in-fez-morocco
#16
Btissam Arhoune, Bouchra Oumokhtar, Fouzia Hmami, Abouddihaj Barguigua, Mohammed Timinouni, Samira El Fakir, Fouzia Chami, Abdelhak Bouharrou
OBJECTIVES: The aim of this study was to investigate the faecal carriage and molecular epidemiology of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (ESBLE) isolated from rectal samples of neonates hospitalised in a neonatal intensive care unit (NICU) of a university hospital in Fez, Morocco. METHODS: From February-July 2013, all neonates hospitalised in the NICU were screened for ESBLE carriage at discharge. ESBLs were identified by double-disk synergy test, PCR and DNA sequencing analysis...
December 27, 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28038460/the-comprehensive-therapeutic-effects-of-rectal-surgery-are-better-in-laparoscopy-a-systematic-review-and-meta-analysis
#17
Jiabin Zheng, Xingyu Feng, Zifeng Yang, Weixian Hu, Yuwen Luo, Yong Li
BACKGROUND: Laparoscopic-assisted radical resection of rectal cancer was reported as advantageous compared to laparotomy resection. However, this finding remains controversial, especially given the two recent randomized controlled trials published on The Journal of the American Medical Association (JAMA). OBJECTIVE: To perform a meta-analysis that compares the short-term and long-term outcomes of laparoscopic and open surgery for rectal cancer. DATA SOURCE: To identify clinical trials comparing laparoscopic and open surgery for rectal cancer published by August 2016, we searched the PubMed, Cochrane Library, Springer Link and Clinicaltrials...
December 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/28011978/what-is-the-best-tool-for-transanal-endoscopic-microsurgery-tem-a-case-matched-study-in-74-patients-comparing-a-standard-platform-and-a-disposable-material
#18
Diane Mege, Valérie Bridoux, Léon Maggiori, Jean-Jacques Tuech, Yves Panis
PURPOSE: Transanal endoscopic microsurgery (TEM) is the gold standard for local excision of rectal lesions, but no study exists concerning the best material. The objective was to compare TEM using a disposable material vs a standard platform through a case-matched study. METHODS: Patients who underwent TEM for rectal neoplasms were identified from prospective databases in two tertiary referral centers and matched according to four criteria (sex, tumor location, size, distance from the anal verge): TEM using a disposable material (GelPoint Applied®; group A) and TEM using a standard TEO® platform (Karl Storz, Tuttlingen, Germany; group B)...
December 24, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28009148/the-impact-of-previous-prostate-surgery-on-the-outcomes-of-laparoscopic-radical-prostatectomy
#19
Paolo Verze, Francesco Greco, Salvatore Scuzzarella, Francesco Bottone, Alessandro Palmieri, Vito Cucchiara, Davide Arcaniolo, Vittorio Imperatore, Massimiliano Creta, Vincenzo Mirone
BACKGROUND: The aim of this study was to evaluate the outcomes in laparoscopic radical prostatectomy (LRP) in patients who had undergone prior prostate surgery (PPS). METHODS: In this study 946 consecutive LR P patients were included and a retrospective comparison between those patients who had received PPS (group A) and those who had not received PPS (group B) was carried out. The preoperative, intraoperative and postoperative data was collected in a prospectively-maintained database...
February 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27992078/basophils-and-mast-cells-are-crucial-for-reactions-due-to-epicutaneous-sensitization-to-ovalbumin
#20
Rie Yu, Ken Igawa, Yutaro Handa, Takichi Munetsugu, Takahiro Satoh, Hiroo Yokozeki
The prevalence of food allergies worldwide has increased recently. Epicutaneous sensitization to antigen could be a method to study food allergy METHODS: To clarify the mechanisms of food allergy, we established a mouse model of epicutaneous sensitization using ovalbumin. BALB/c mice were sensitized by three-time application of ovalbumin to tape-stripped skin (1-week sensitization at 2-week intervals) and oral challenge of ovalbumin undertaken. Rectal temperature was monitored. Blood and tissue (skin and jejunum) of challenged mice were taken...
December 19, 2016: Experimental Dermatology
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