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https://www.readbyqxmd.com/read/29684805/detecting-a-rare-composite-small-bowel-lymphoma-by-magnetic-resonance-imaging-coincidentally-a-case-report-with-radiological-surgical-and-histopathological-features
#1
M Pezzella, B Brogna, A Romano, F Torelli, G Esposito, M Petrillo, F M Romano, N Di Martino, A Reginelli, R Grassi
INTRODUCTION: Diagnosing lymphoma continues to prove challenging in the clinical practice. Composite lymphoma (CL) is defined by the coexistence of different lymphoma subtypes in the same anatomical location. This condition has seldom been witnessed in the gastrointestinal (GI) tract. We weren't able to find previous cases in the literature about small bowel CL with follicular lymphoma (FL) and classical Hodgkin lymphoma (CHL). Surgery is the treatment of choice to obtain accurate histology, to manage and prevent acute complications...
April 16, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29682712/-incidence-and-risk-factors-for-anastomotic-leakage-after-anterior-resection-for-rectal-cancer
#2
Jun Li, Yongbo An, Guocong Wu, Xiaomu Zhao, Yingchi Yang, Jin Wang, Lan Jin, Hongwei Wu, Na Zeng, Fuxiao Xie, Jie Dong, Anlong Yuan, Wuqing Sun, Ruiqing Zhou, Hongwei Yao, Zhongtao Zhang
OBJECTIVE: To assess the incidence and independent risk factors for clinical anastomotic leakage (AL) in patients undergoing anterior resection(AR) or low anterior resection, (LAR) for rectal cancer. METHODS: This was a retrospective case-control study of 550 patients with rectal cancer who underwent AR or LAR from April 2007 to March 2017 in Beijing Friendship Hospital, Capital Medical University. The relationship between the incidence of AL and clinicopathological manifestations was analyzed by Chi-squared test and Fisher exact test, and the independent risk factors of AL were analyzed using logistic regression analysis...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29679245/a-systematic-review-of-minimally-invasive-surgery-for-retrorectal-tumors
#3
REVIEW
T G Mullaney, A L Lightner, M Johnston, S R Kelley, D W Larson, E J Dozois
Retrorectal tumors are rare tumors that require resection for symptoms, malignancy and potential malignant transformation. Traditional approaches have included laparotomy, perineal excision or a combination. Multiple minimally invasive techniques are available which have the potential to minimize morbidity and enhance recovery. We performed a systematic review of the literature to determine the feasibility and surgical outcomes of retrorectal tumors approached using minimally invasive surgical techniques. Publications in which adult patients (≥ 18 years) had a minimally invasive approach (laparoscopic or robotic) for resection of a primary retrorectal tumor were included...
April 20, 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29668947/incidence-and-predictors-of-success-of-adalimumab-dose-escalation-and-de-escalation-in-ulcerative-colitis-a-real-world-belgian-cohort-study
#4
Saartje Van de Vondel, Filip Baert, Christine Reenaers, Stijn Vanden Branden, Leila Amininejad, Pieter Dewint, Wouter Van Moerkercke, Jean-François Rahier, Pieter Hindryckx, Peter Bossuyt, Marc Ferrante
Background: Adalimumab (ADM) has been shown efficacious in ulcerative colitis (UC). In randomized controlled trials, dose escalation from 40 mg ADM every other week to 40 mg every week was required in 20%-25% of patients within 1 year. Real-life data suggest higher escalation rates. Attempts for dose de-escalation have not been studied yet. We assessed the need for, outcome of, and predictors of dose escalation and de-escalation in a large retrospective cohort of UC patients treated with ADM...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29665309/association-between-operative-technique-and-intrusive-thoughts-on-health-related-quality-of-life-3-years-after-ape-elape-for-rectal-cancer-results-from-a-national-swedish-cohort-with-comparison-with-normative-swedish-data
#5
Mattias Prytz, Anna Ledebo, Eva Angenete, David Bock, Eva Haglind
The aim of this prospective registry-based population study was to investigate the association between QoL 3 years after surgery for rectal cancer and intrusive thoughts and to assess the association with the type of surgery (i.e., APE or ELAPE) in a population-based national cohort. ELAPE has been proposed as a superior surgical technique for distal rectal cancer, but long-term effects on QoL are not known. There are also no studies on the association of negative intrusive thoughts on patients' self-reported Quality of Life following surgery for distal rectal cancer...
April 17, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29663854/cyclin-dependent-kinase-1-targeting-improves-sensitivity-to-radiation-in-braf-v600e-colorectal-carcinoma-cells
#6
Girolamo Spagnoletti, Valeria Li Bergolis, Annamaria Piscazzi, Francesca Giannelli, Valentina Condelli, Lorenza Sisinni, Giuseppe Bove, Giovanni Storto, Matteo Landriscina
OBJECTIVES: Preoperative chemoradiation is currently the standard of care in locally advanced rectal carcinoma, even though a subset of rectal tumors does not achieve major clinically meaningful responses upon neoadjuvant chemoradiation. At present, no molecular biomarkers are available to predict response to neoadjuvant chemoradiation and select resistant tumors willing more intense therapeutic strategies. Thus, BRAF mutational status was investigated for its role in favoring resistance to radiation in colorectal carcinoma cell lines and cyclin-dependent kinase 1 as a target to improve radiosensitivity in BRAF V600E colorectal tumor cells...
April 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29663417/technical-note-a-deep-learning-based-auto-segmentation-of-rectal-tumors-in-mr-images
#7
Jiazhou Wang, Jiayu Lu, Gan Qin, Lijun Shen, Yiqun Sun, Hongmei Ying, Zhen Zhang, Weigang Hu
PURPOSE: Manual contouring of gross tumor volumes (GTV) is a crucial and time-consuming process in rectum cancer radiotherapy. This study aims to develop a simple deep learning based auto segmentation algorithm to segment rectal tumors on T2 weighted MR images. MATERIAL AND METHODS: MRI scans (3T, T2-weighted) of 93 patients with locally advanced (cT3-4 and/or cN1-2) rectal cancer treated with neoadjuvant chemoradiotherapy followed by surgery were enrolled in this study...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29652817/selenium-in-radiation-oncology-15-years-of-experiences-in-germany
#8
REVIEW
Ralph Muecke, Oliver Micke, Lutz Schomburg, Jens Buentzel, Klaus Kisters, Irenaeus A Adamietz
Introduction: Se measurement and supplementation in radiation oncology is a controversial issue. The German Working Group Trace Elements and Electrolytes in Oncology (AKTE) has conducted a number of studies on this issue, which are summarized in this review. Strategies have been tested and developed, aiming to stratify the patients with a potential need for supplemental Se and how best to monitor Se supplementation with respect to health effects and risks. Methods: We analyzed blood and tissue Se-levels of different tumor patients ( n = 512)...
April 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29650851/-a-case-of-isolated-lateral-pelvic-lymph-node-recurrence-after-tme-for-early-lower-rectal-cancer-treated-with-laparoscopic-lateral-lymph-node-dissection
#9
Ryuichiro Kimura, Masayoshi Yasui, Masayuki Ohue, Yusuke Takahashi, Norikatsu Miyoshi, Yoshitomo Yanagimoto, Keijiro Sugimura, Akira Tomokuni, Hirofumi Akita, Moon Jeong-Ho, Shogo Kobayashi, Hidenori Takahashi, Takeshi Omori, Yoshiyuki Fujiwara, Hiroshi Miyata, Masahiko Yano, Masato Sakon
There are no established treatment protocol for isolated lateral lymph node recurrence in patients with T1 lower rectal cancer, because such case is very rare. In our institution, this is the only recorded case of lateral node recurrence post-resection. It has been documented in several studies that salvage surgery for colorectal cancer improves prognosis. However, there were only 3 reported cases found for lateral lymph node metastasis from colorectal cancer that underwent excision. In this study, we report a rare case of lateral lymph node recurrence after trans-anal resection for T1 lower rectal cancer wherein we performed laparoscopic right lateral pelvic lymph node dissection...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29649396/surgeons-perceived-barriers-to-palliative-and-end-of-life-care-a-mixed-methods-study-of-a-surgical-society
#10
Pasithorn A Suwanabol, Ari C Reichstein, Z Tuba Suzer-Gurtekin, Jane Forman, Maria J Silveira, Lona Mody, Arden M Morris
BACKGROUND: Nearly 20% of colorectal cancer (CRC) patients present with potentially incurable (Stage IV) disease, yet their physicians do not integrate cancer treatment with palliative care. Compared with patients treated by primary providers, surgical patients with terminal diseases are significantly less likely to receive palliative or end-of-life care. OBJECTIVE: To describe surgeon perspectives on palliative and end-of-life care for patients with Stage IV CRCs...
March 13, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29628389/effects-of-buprenorphine-butorphanol-or-tramadol-premedication-on-anaesthetic-induction-with-alfaxalone-in-common-marmosets-callithrix-jacchus
#11
Jaco Bakker, Sandra Roubos, Edmond J Remarque, Saskia S Arndt, Peter W Kronen, Jan Am Langermans
OBJECTIVE: To investigate the clinical and physiological effects of intravenous (IV) alfaxalone alone or in combination with buprenorphine, butorphanol or tramadol premedication in marmosets. STUDY DESIGN: Prospective, randomized, blinded, crossover design. ANIMALS: Nine healthy marmosets (391 ± 48 g, 3.7 ± 2.2 years old). METHODS: Meloxicam 0.20 mg kg-1 subcutaneously, atropine 0.05 mg kg-1 intramuscularly (IM) and either buprenorphine 20 μg kg-1 IM (BUP-A), butorphanol 0...
February 5, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29619053/dosimetric-analysis-of-the-effects-of-the-bladder-volume-on-organs-at-risk-oar-in-high-dose-rate-intracavitary-brachytherapy-in-carcinoma-cervix-an-institutional-study
#12
Ashutosh Das Sharma, Jyoti Poddar, U Suryanarayan K, Sonal Patel Shah, Ankita Parikh, Vimesh Mehta, Med Phys, Tarun Kumar, Med Phys
Purpose: The purpose of this study was to establish a dosimetric correlation between the bladder volume and its effects on the dose received by the organs at risk (OARs) (urinary bladder, rectum, and sigmoid) during computed tomography (CT)-guided high-dose-rate (HDR) brachytherapy in carcinoma cervix, and to determine an optimum bladder volume to limit the dose to OARs. Material and methods: Seventy-five intracavitary applications in patients of carcinoma cervix (stage IIB, IIIA, IIIB, IVA) treated with external beam radiotherapy with concurrent chemotherapy followed by CT-based HDR intracavitary brachytherapy (tandem and ovoid type) at our institute between July 2014 to January 2016 were studied...
February 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29617381/prevention-of-colonic-neoplasia-with-polyethylene-glycol-a-short-term-randomized-placebo-controlled-double-blinded-trial
#13
Ramesh K Wali, Laura Bianchi, Sonia Kupfer, Mart De La Cruz, Borko Jovanovic, Christopher Weber, Michael J Goldberg, L M Rodriguez, Raymond Bergan, David Rubin, Mary Beth Tull, Ellen Richmond, Beth Parker, Seema Khan, Hemant K Roy
Chemoprevention represents an attractive modality against colorectal cancer (CRC) although widespread clinical implementation of promising agents (e.g. aspirin/NSAIDS) have been stymied by both suboptimal efficacy and concerns over toxicity. This highlights the need for better agents. Several groups, including our own, have reported that the over-the-counter laxative polyethylene glycol (PEG) has remarkable efficacy in rodent models of colon carcinogenesis. In this study, we undertook the first randomized human trial to address the role of PEG in prevention of human colonic neoplasia...
2018: PloS One
https://www.readbyqxmd.com/read/29609953/determination-of-prostate-volume-a-comparison-of-contemporary-methods
#14
Adam Bezinque, Andrew Moriarity, Crystal Farrell, Henry Peabody, Sabrina L Noyes, Brian R Lane
RATIONALE AND OBJECTIVES: Prostate volume (PV) determination provides important clinical information. We compared PVs determined by digital rectal examination (DRE), transrectal ultrasound (TRUS), magnetic resonance imaging (MRI) with or without three-dimensional (3D) segmentation software, and surgical prostatectomy weight (SPW) and volume (SPV). MATERIALS AND METHODS: This retrospective review from 2010 to 2016 included patients who underwent radical prostatectomy ≤1 year after multiparametric prostate MRI...
March 30, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29605024/benchmarking-rectal-cancer-care-institutional-compliance-with-a-longitudinal-checklist
#15
William C Chapman, Pamela Choi, Alexander T Hawkins, Steven R Hunt, Matthew L Silviera, Paul E Wise, Matthew G Mutch, Sean C Glasgow
BACKGROUND: In 2012, the American Society of Colon and Rectal Surgeons published the Rectal Cancer Surgery Checklist, a consensus document listing 25 essential elements of care for all patients undergoing radical surgery for rectal cancer. The authors herein examine checklist adherence in a mature, multisurgeon specialty academic practice. MATERIALS AND METHODS: A retrospective medical record review of patients undergoing elective radical resection for rectal adenocarcinoma over a 23-mo period was conducted...
May 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29600904/a-case-of-junctional-neural-tube-defect-associated-with-a-lipoma-of-the-filum-terminale-a-new-subtype-of-junctional-neural-tube-defect
#16
Simona Mihaela Florea, Alice Faure, Hervé Brunel, Nadine Girard, Didier Scavarda
The embryological development of the central nervous system takes place during the neurulation process, which includes primary and secondary neurulation. A new form of dysraphism, named junctional neural tube defect (JNTD), was recently reported, with only 4 cases described in the literature. The authors report a fifth case of JNTD. This 5-year-old boy, who had been operated on during his 1st month of life for a uretero-rectal fistula, was referred for evaluation of possible spinal dysraphism. He had urinary incontinence, clubfeet, and a history of delayed walking ability...
March 30, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29594202/time-to-surgery-and-pathologic-complete-response-after-neoadjuvant-chemoradiation-in-rectal-cancer-a-population-study-on-2094-patients
#17
Gabriella Macchia, Maria Antonietta Gambacorta, Carlotta Masciocchi, Giuditta Chiloiro, Giovanna Mantello, Maika di Benedetto, Marco Lupattelli, Elisa Palazzari, Liliana Belgioia, Almalina Bacigalupo, Aldo Sainato, Sabrina Montrone, Lucia Turri, Angela Caroli, Antonino De Paoli, Fabio Matrone, Carlo Capirci, Giampaolo Montesi, Rita Marina Niespolo, Mattia Falchetto Osti, Luciana Caravatta, Alessandra Galardi, Domenico Genovesi, Maria Elena Rosetto, Caterina Boso, Piera Sciacero, Lucia Giaccherini, Salvatore Parisi, Antonella Fontana, Francesco Romeo Filippone, Vincenzo Picardi, Alessio Giuseppe Morganti, Vincenzo Valentini
Background: To retrospectively evaluate the difference in terms of pathologic complete response (pCR) according to time elapsed between chemoradiation (CRT) and total mesorectal excision (TME) on a large unselected real-life dataset of locally advanced rectal cancer (LARC) patients. Methods: A multicentre retrospective cohort study of LARC patients from 21 Italian Radiotherapy Institutions was performed. Patients were stratified into 3 different time intervals from CRT...
June 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29593430/prospective-study-of-neoadjuvant-chemoradiotherapy-using-intensity-modulated-radiotherapy-and-5-fluorouracil-for-locally-advanced-rectal-cancer-toxicities-and-response-assessment
#18
David K Simson, Swarupa Mitra, Parveen Ahlawat, Upasna Saxena, Manoj Kumar Sharma, Sheh Rawat, Harpreet Singh, Babita Bansal, Lalitha Kameshwari Sripathi, Aditi Tanwar
Aims and objectives: The past 2 decades witnessed the strengthening of evidence favoring the role of neoadjuvant chemoradiation (CHRT) in the treatment of locally advanced rectal cancer. The study aims to evaluate the response and acute toxicities to neoadjuvant CHRT using intensity-modulated radiotherapy (IMRT) in the treatment of rectal cancer. Predictive factors to achieve pathological complete response (pCR) were analyzed, as a secondary endpoint. Materials and methods: All consecutive patients who underwent IMRT as part of neoadjuvant CHRT in the treatment of rectal cancer between August 2014 and December 2016 at a tertiary cancer care center were accrued for the study...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29580202/carcinoembryonic-antigen-as-a-marker-of-radioresistance-in-colorectal-cancer-a-potential-role-of-macrophages
#19
Eng-Yen Huang, Jen-Chieh Chang, Hong-Hwa Chen, Chieh-Ying Hsu, Hsuan-Chih Hsu, Keng-Liang Wu
BACKGROUND: We sought to identify the carcinoembryonic antigen (CEA) as a marker of radioresistance in rectal cancer. METHODS: From July 1997 to January 2008, 104 patients with stage II or III rectal cancer who were treated with post-operative radiotherapy (PORT) were included in this study. The doses of radiotherapy ranged from 45 to 54.6 Gy. The CEA levels were measured before surgery. We analyzed the actuarial rates of overall survival (OS), distant metastasis (DM), and local recurrence (LR) using Kaplan-Meier curves...
March 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29577214/-significance-of-the-preservation-of-left-colic-artery-in-laparoscopic-resection-of-rectal-cancer
#20
Xinxiang Li, Qingguo Li
Controversy remains on how to manage left colic artery (LCA) when it comes to laparoscopic proctectomy. With regard to the level of detachment, a high tie of inferior mesenteric artery (IMA) is meant as a ligation at the origin of aorta, while the low tie is the ligation of IMA below the initiation part of left colic artery which is left. Several key points of LCA preservation, including clinical value, oncologic safety and the difficulty of operation, have always been debated. Some scholars hold the point of view that the preservation of LCA will hamper the lymph nodes dissection around the inferior mesenteric artery, resulting in incorrect pathological staging and dismal outcome...
March 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
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