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https://www.readbyqxmd.com/read/29784840/oxidative-stress-and-first-line-antituberculosis-drug-induced-hepatotoxicity
#1
Wing Wai Yew, Kwok Chiu Chang, Denise P Chan
Hepatotoxicity induced by antituberculosis drugs is a serious adverse reaction with significant morbidity and even rarely mortality. This form of toxicity potentially impacts the treatment outcome of tuberculosis in some patients. Confining to first-line antituberculosis drugs, this review addresses whether and how oxidative stress, and more broadly, disturbance in redox homeostasis alongside mitochondrial dysfunction, may contribute to the hepatotoxicity induced by them. Risk factors for such toxicity that have been identified, in addition to genetic factors, principally include old age, malnutrition, alcoholism, chronic hepatitis C and chronic hepatitis B infection, HIV infection and pre-existing liver disease...
May 21, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29783726/case-report-of-isoniazid-related-acute-liver-failure-requiring-liver-transplantation
#2
Andrew A Li, Pratima Dibba, George Cholankeril, Donghee Kim, Aijaz Ahmed
The prevalence of latent tuberculosis infection (LTBI) in the United States in 2011 and 2012 was estimated at 4.4⁻4.8%. As of 2015, 12.4 million people still possessed LTBI. Isoniazid, or isonicotinic acid hydrazine (INH), is the most commonly used medication among varying regimens that exist in the treatment of tuberculosis and LTBI. INH-related hepatotoxicity is a well-known adverse effect of its use, often causing asymptomatic elevations in serum aminotransferase levels. These elevations are typically transient and reversible, but can cause acute, clinically-significant liver injury in rare cases...
May 19, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29779299/health-issues-of-refugees-attending-an-infectious-disease-refugee-health-clinic-in-a-regional-australian-hospital
#3
Peta J Masters, Penelope J Lanfranco, Emmy Sneath, Amanda J Wade, Sarah Huffam, James Pollard, James Standish, Kate McCloskey, Eugene Athan, Daniel P O'Brien, N Deborah Friedman
BACKGROUND AND OBJECTIVES: Refugees in Australia present with conditions different to those of the general population. The aim of this study was to review the reasons for referral, prevalence of conditions and treatment outcomes for refugee patients attending a specialist referral clinic in regional Victoria. METHOD: A retrospective review was undertaken of patients attending the refugee health clinic at University Hospital Geelong from January 2007 to December 2012...
May 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29778396/how-effective-are-approaches-to-migrant-screening-for-infectious-diseases-in-europe-a-systematic-review
#4
REVIEW
Farah Seedat, Sally Hargreaves, Laura B Nellums, Jing Ouyang, Michael Brown, Jon S Friedland
Rates of migration to Europe, and within Europe, have increased in recent years, with considerable implications for health systems. Migrants in Europe face a disproportionate burden of tuberculosis, HIV, and hepatitis B and C, yet experience a large number of barriers to accessing statutory health care on arrival. A better understanding of how to deliver effective and cost-effective screening, vaccination, and health services to this group is now crucial. We did a systematic review to document and assess the effectiveness and cost-effectiveness of approaches used for infectious diseases screening, and to explore facilitators and barriers experienced by migrants to accessing screening programmes...
May 16, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29773321/evaluating-scenarios-of-locations-and-capacities-for-vaccine-storage-in-nigeria
#5
Dor Hirsh Bar Gai, Zachary Graybill, Paule Voevodsky, Ekundayo Shittu
Many developing countries still face the prevalence of preventable childhood diseases because their vaccine supply chain systems are inadequate by design or structure to meet the needs of their populations. Currently, Nigeria is evaluating options in the redesign of the country's vaccine supply chain. Using Nigeria as a case study, the objective is to evaluate different regional supply chain scenarios to identify the cost minimizing optimal hub locations and storage capacities for doses of different vaccines to achieve a 100% fill rate...
May 14, 2018: Vaccine
https://www.readbyqxmd.com/read/29770077/outbreaks-in-the-age-of-syndemics-new-insights-for-improving-indigenous-health
#6
A Andermann
Conventional approaches for the prevention and control of communicable diseases within Indigenous contexts may benefit from new insights arising from the growing interest in syndemics. Syndemics is a term used to describe a conceptual framework for understanding diseases or health conditions, and how these are exacerbated by the social, economic, environmental and political milieu in which a population is immersed. The use of conventional approaches for outbreak prevention and control remains the bedrock of intervention in the field of communicable diseases; yet on their own, these strategies are not always successful, especially within contexts of marginalization and disadvantage...
June 1, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29762203/preparing-patients-for-biologic-medications-for-dermatologic-and-rheumatic-diseases
#7
Benjamin J Smith, Brigitta C Nuccio, Katelyn Y Graves, Victor M McMillan
Psoriasis, psoriatic arthritis, and rheumatoid arthritis are prevalent conditions that often require a team of primary care and specialist healthcare professionals for the most optimum patient outcomes. Primary care providers can facilitate referrals to dermatology and rheumatology specialists by obtaining the needed screening workup for patients who need treatment with immunosuppressive therapies. This article reviews tuberculosis screening, hepatitis screening, and vaccinations to be administered before patients begin biologic medications...
May 8, 2018: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/29759945/diagnosis-of-local-hepatic-tuberculosis-through-next-generation-sequencing-smarter-faster-and-better
#8
Jing-Wen Ai, Yang Li, Qi Cheng, Peng Cui, Hong-Long Wu, Bin Xu, Wen-Hong Zhang
BACKGROUND: A 45-year-old man who complained of continuous fever and multiple hepatic masses was admitted to our hospital. Repeated MRI manifestations were similar while each radiological report suggested contradictory diagnosis pointing to infections or malignances respectively. Pathologic examination of the liver tissue showed no direct evidence of either infections or tumor. We performed next-generation sequencing on the liver tissue and peripheral blood to further investigate the possible etiology...
May 11, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29743831/evidence-based-consensus-on-opportunistic-infections-in-inflammatory-bowel-disease-republication
#9
REVIEW
(no author information available yet)
Inflammatory bowel disease (IBD) patients are a high-risk population for opportunistic infections. The IBD group of the Chinese Society of Gastroenterology of the Chinese Medical Association organized an expert group to discuss and develop this consensus opinion. This consensus opinion referenced clinical study results from China and other countries to provide guidance for clinical practices. Eight major topics, including cytomegalovirus infection, Epstein-Barr virus infection, viral hepatitis, bacterial infection, Mycobacterium tuberculosis infection, fungal infection, parasitic infection, and vaccines were introduced in this article...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29739700/catalysing-the-development-and-introduction-of-paediatric-drug-formulations-for-children-living-with-hiv-a-new-global-collaborative-framework-for-action
#10
Martina Penazzato, Melynda Watkins, Sébastien Morin, Linda Lewis, Fernando Pascual, Marissa Vicari, Janice Lee, Sally Hargreaves, Meg Doherty, George K Siberry
Progress in the development and introduction of paediatric formulations for key infectious diseases is poor in low-income and middle-income countries (LMICs). Although major steps have been made in the scale-up of antiretroviral medicines in LMICs, the development and deployment of formulations for infants and children is suboptimal. Of the children living with HIV globally (most in Africa), only 43% are receiving antiretroviral therapy (ART), many with suboptimal formulations. These shortfalls pose a series of challenges to meeting global treatment targets of 1·6 million children (aged 0-14 years) on ART by the end of 2018 (95% coverage) and to ensuring that 95% of those on ART are virologically suppressed...
May 2018: Lancet HIV
https://www.readbyqxmd.com/read/29735782/an-overview-of-liver-transplant-pathology-data-from-a-tertiary-referral-centre-in-western-india
#11
Fiona Fonseca, Bijal Kulkarni, Meenal Hastak, Vinay Kumaran, Vibha Varma, Sorabh Kapoor
INTRODUCTION AND AIM: 1. Study of liver explants - Etiologic types of end-stage chronic liver disease (ESCLD) and acute liver failure (ALF) in adults and children. 2. Assessment of donor steatosis and incidental granulomas. 3. Post-transplant liver biopsies. MATERIAL AND METHODS: Specimens of 180 explant hepatectomies, 173 donor wedge and 30 core liver biopsies, and 58 post transplant liver biopsies received in our department from April 2013 to March 2017. RESULTS: 1...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29722039/mortality-from-adverse-drug-reaction-related-hospitalizations-in-south-west-ethiopia-a-cross-sectional-study
#12
M T Angamo, L Chalmers, C M Curtain, D Yilma, L Bereznicki
WHAT IS KNOWN AND OBJECTIVE: Adverse drug reactions (ADRs) are an important cause of mortality during medical care. To our knowledge, no Ethiopian studies have reported on mortality due to ADRs in patients presenting to hospital from the community setting. The aim of this study was to determine the mortality rate attributable to ADRs in patients presenting to hospital, identify drugs implicated in the ADR-related deaths and identify factors contributing to ADR-related mortality at Jimma University Specialised Hospital (JUSH), south-west Ethiopia METHODS: This cross-sectional study included 1001 patients aged ≥18 years consecutively admitted to medical wards from May 2015 to August 2016...
May 2, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29718967/mycobactericidal-activity-of-bedaquiline-plus-rifabutin-or-rifampin-in-ex-vivo-whole-blood-cultures-of-healthy-volunteers-a-randomized-controlled-trial
#13
Robert S Wallis, Caryn E Good, Mary A O'Riordan, Jeffrey L Blumer, Michael R Jacobs, J McLeod Griffiss, Amanda Healan, Robert A Salata
BACKGROUND: Bedaquiline, an antimycobacterial agent approved for drug-resistant tuberculosis, is metabolized by CYP3A4, an hepatic enzyme strongly induced by rifampin, an essential part of drug-sensitive tuberculosis treatment. We examined the pharmacokinetic interactions of bedaquiline plus either rifampin or rifabutin in 33 healthy volunteers. This sub-study of that trial examined the mycobactericidal activity of these drugs against intracellular Mycobacterium tuberculosis using ex vivo whole blood culture...
2018: PloS One
https://www.readbyqxmd.com/read/29698255/when-do-co-infections-matter
#14
Andrew J McArdle, Anna Turkova, Aubrey J Cunnington
PURPOSE OF REVIEW: Advances in diagnostic methods mean that co-infections are increasingly being detected in clinical practice, yet their significance is not always obvious. In parallel, basic science studies are increasingly investigating interactions between pathogens to try to explain real-life observations and elucidate biological mechanisms. RECENT FINDINGS: Co-infections may be insignificant, detrimental, or even beneficial, and these outcomes can occur through multiple levels of interactions which include modulation of the host response, altering the performance of diagnostic tests, and drug-drug interactions during treatment...
June 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29693409/nodular-hepatic-tuberculosis-masquerading-as-a-seminoma-liver-metastasis
#15
Houssem Harbi, Amine Chaabouni, Rim Kallel, Nozha Toumi, Sami Fendri, Jihene Krichene, Salah Boujelbene, Rafik Mzali
Isolated macro-nodular liver tuberculosis is a very rare condition. It may mimic primitive or secondary tumors of the liver. This could delay or mislead the therapeutic management. An immunocompetent 48-year-old man with a history of non-metastatic seminoma was treated with right orchidectomy followed by 20 Gy radiotherapy. The discovery, 8 months later, of a 2 cm nodule of the hepatic dome evoked a liver metastasis. Percutaneous biopsy was not feasible. Wedge resection was performed whereas medical treatment would have sufficed, as pathologic examination of the resected specimen showed a macro-nodular hepatic tuberculosis...
April 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29692453/controversies-in-the-management-of-cutaneous-adverse-drug-reactions
#16
Yashpal Manchanda, Sudip Das, Aarti Sarda, Projna Biswas
Some cutaneous adverse drug reactions (CADRs) are severe life-threatening conditions due to multisystem involvements with a high morbidity and mortality rates ranging from 25 - 70% and require immediate medical care. But there are huge controversies regarding the management because large clinical trials are lacking. Most frequent discussion and division occur regarding the use of systemic corticosteroid as early intervention with corticosteroids controls inflammation. Corticosteroids are potent agents that target several intracellular processes to modify almost all components of inflammatory and immune responses but their impact on the long term disease course is not known...
March 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29692316/extended-screening-for-infectious-diseases-among-newly-arrived-asylum-seekers-from-africa-and-asia-verona-province-italy-april-2014-to-june-2015
#17
Dora Buonfrate, Federico Gobbi, Valentina Marchese, Chiara Postiglione, Geraldo Badona Monteiro, Giovanni Giorli, Giuseppina Napoletano, Zeno Bisoffi
Background and aimManagement of health issues presented by newly-arrived migrants is often limited to communicable diseases even though other health issues may be more prevalent. We report the results of infectious disease screening proposed to 462 recently-arrived asylum seekers over 14 years of age in Verona province between April 2014 and June 2015. Methods: Screening for latent tuberculosis (TB) was performed via tuberculin skin test (TST) and/or QuantiFERON-TB Gold in-tube assay and/or chest X-ray. An ELISA was used to screen for syphilis...
April 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29674071/direct-e-dna-sensor-of-mycobacterium-tuberculosis-mutant-strain-based-on-new-nanocomposite-transducer-fc-ac-ompa-mwcnts
#18
Salma Bizid, Saber Blili, Rym Mlika, Ayoub Haj Said, Hafsa Korri-Youssoufi
Direct DNA sensor based on new nanocomposite materials (Fc-ac-OMPA/MWCNTs) has been investigated. This nanocomposite was formed by combining the redox oligomer "oligo-methoxy-phenyl-acetonitrile" (Fc-ac-OMPA) and the MWCNTs via a simple π-π stacking interaction in the aim to ameliorate the biosensor performance. The redox indicator and the functional groups of the redox oligomer have been used for monitoring the electrochemical behavior and the flexibility for direct covalent attachment of Hepatitis C DNA probe...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29671563/rheumatoid-arthritis-common-questions-about-diagnosis-and-management
#19
Amy Wasserman
Rheumatoid arthritis is the most commonly diagnosed systemic inflammatory arthritis, with a lifetime prevalence of up to 1% worldwide. Women, smokers, and those with a family history of the disease are most often affected. Rheumatoid arthritis should be considered if there is at least one joint with definite swelling that is not better explained by another disease. In a patient with inflammatory arthritis, the presence of a rheumatoid factor and/or anti-citrullinated protein antibody, elevated C-reactive protein level, or elevated erythrocyte sedimentation rate is consistent with a diagnosis of rheumatoid arthritis...
April 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29665974/reactivation-of-peritoneal-and-pleural-tuberculosis-during-hepatitis-c-treatment-with-direct-acting-antivirals
#20
Marc Pedrosa, Sara Nogales, Mercedes Vergara, Mireia Miquel, Meritxell Casas, Blai Dalmau, Bernat Font, Jordi Sánchez-Delgado
No abstract text is available yet for this article.
April 14, 2018: Gastroenterología y Hepatología
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