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Alberto A Carena, Laura Jorge, Pablo Bonvehí, Elena Temporiti, Mariela S Zárate, Fabián Herrera
Fluorquinolone-prophylaxis has proven useful in preventing infections in high risk neutropenic patients. The objective of this study was to describe the clinical, microbiological and therapeutic characteristics, and outcome of patients in the first episode of febrile neutropenia, comparing those who received levofloxacin prophylaxis with those who didn't. It was a prospective observational study that included all the episodes of inpatients with febrile neutropenia (February 1997- November 2014), also including the first episode in a same patient in different hospitalizations...
2016: Medicina
Mar Olga Pérez-Moreno, María José Centelles-Serrano, Julio Nogales-López, Marie France Domenech-Spanedda, Carmen Lozano, Carmen Torres
OBJECTIVE: To characterize a methicillin-resistant Staphylococcus aureus (MRSA) isolate responsible for an aggressive infection (peridural and psoas abscess secondary to haematogenous septic arthritis) in a poultry farmer. METHODS: Molecular characterization was performed, including spa- and multilocus sequence typing of the isolate, assessment of its resistance phenotype and detection of tetracycline resistance and of virulence and immune evasion cluster (IEC) genes were performed...
August 31, 2016: Enfermedades Infecciosas y Microbiología Clínica
Nicol Janecko, Lucie Pokludova, Jana Blahova, Zdenka Svobodova, Ivan Literak
Until recently, the behaviour of antibiotics and their ecotoxicological impact have been overlooked in the environment. The topic is broad and encompasses a wide range of organisms including microorganisms, algae, invertebrates and vertebrates inhabiting various aquatic ecosystems. Changing the equilibrium of any one component in such systems disrupts the balance of the whole system. The manufacturing and frequent use of fluoroquinolones in human and animal medicine raises great concern over the increase of antibiotic resistance prevalence in microorganisms, however, in addition to that, the fate of antibiotic parent and metabolite compounds entering environmental ecosystems through various pathways raise environmental impact concerns...
July 8, 2016: Environmental Toxicology and Chemistry
Gustavo Miranda Martins, Bruno Squárcio Fernandes Sanches, Luciana Dias Moretzsohn, Karine Sampaio Lima, Bianca Della Croce V Cota, Luiz Gonzaga Vaz Coelho
BACKGROUND: - Antimicrobial resistance is the major factor leading to eradication failure in H. pylori treatment. Molecular tests are useful to detect genetic mutations predictive of clarithromycin and fluoroquinolones resistance. Knowledge of the local prevalence rate of resistance is important to define the best recommended treatment. OBJECTIVE: - To assess the prevalence of primary resistance of H. pylori to clarithromycin and fluoroquinolones, using a molecular test, in a Southeastern urban Brazilian population...
April 2016: Arquivos de Gastroenterologia
Michael Haap
No abstract text is available yet for this article.
March 2016: Deutsche Medizinische Wochenschrift
Clésio Soldateli Paim, Fernanda Führ, Magda Targa Martins, Simone Gnoatto, Lisiane Bajerski, Cássia Virginia Garcia, Martin Steppe, Elfrides Eva Scherman Schapoval
Gemifloxacin mesylate (GFM), chemically (R,S)-7-[(4Z)-3-(aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid methanesulfonate, is a synthetic broad-spectrum antibacterial agent. Although many papers have been published in the literature describing the stability of fluorquinolones, little is known about the degradation products of GFM. Forced degradation studies of GFM were performed using radiation (UV-A), acid (1 mol L(-1) HCl) and alkaline conditions (0...
March 2016: Biomedical Chromatography: BMC
Tommaso Cai, Cosimo De Nunzio, Andrea Salonia, Federico Pea, Teresita Mazzei, Ercole Concia, Michele Battaglia, Vincenzo Mirone
PURPOSE: Recent epidemiological data have confirmed the increasing problem of antimicrobial resistance not only for hospitalized, healthcare-associated patients, but also for outpatients. In particular, the progressive increase in resistance to broad-spectrum antibiotics, such as third-generation cephalosporins, fluoroquinolones or carbapenems in Enterobacteriaceae, is an alarming situation for all urologists and general practitioners. Here, we aimed to review the epidemiological data of multidrug-resistant bacteria in the urological setting, in order to summarize all diagnostic and therapeutic recommendations to use in everyday clinical practice...
March 5, 2016: Urologia
Tea Meloni, Piera A Martino, Valeria Grieco, Maria C Pisu, Barbara Banco, Alessandro Rota, Maria C Veronesi
Bacterial infections represent the second cause of neonatal morbidity and mortality in dogs, so the present study aimed to investigate the bacterial involvement in canine neonatal mortality and to evaluate the antibiotic susceptibility of the isolated bacteria. Fifty-one newborn purebred puppies, born dead or dead within 28 days of age, belonging to 36 different litters, were enrolled and the following procedures were performed on their fresh dead bodies: necropsy, collection of swabs by liver, kidney, lung, small bowel, and possible thoracic and/ or abdominal effusion, for both bacteriological examination and antimicrobial susceptibility testing, and collection of samples by the same organs for histology...
December 29, 2014: Veterinaria Italiana
Riccardo Bartoletti, Tommaso Cai
OBJECTIVES: Perioperative antibiotic prophylaxis is considered a safe and valid option from the urologist to prevent infective complications after prostate biopsy procedure. The transrectal approach is the most experienced by European urologists and the prevalence of infective complications from this procedure is increasing. Aim of this mini-review article is to improve the urologist knowledge on the prevention of infective complications after prostate transrectal biopsy. METHODS: Recent publications from Medline and Cochrane Library have been collected...
October 2014: Urologia
Edilson Floriano Dos Santos, Liana Lauria-Pires
OBJECTIVE: To know and compare the patterns of antimicrobials use in intensive care units (ICUs) based on the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) system. METHODS: a prospective cohort study was conducted in three medical-surgical intensive care units, two of them in public hospitals and one in a private hospital. Simple random, independent samples of patients admitted from 10/2004 to 09/2005 to the selected intensive care units were used...
June 2010: Revista Brasileira de Terapia Intensiva
Sascha Abbas, Peter Ihle, Sebastian Harder, Ingrid Schubert
There is major concern about coumarins interacting with various drug classes and increasing the risk of overanticoagulation. The aim of the study was to assess bleeding risk in patients with concurrent use of antibiotics and phenprocoumon, the most widely prescribed coumarin in many European countries. We conducted a nested-case-control study within a cohort of 513,338 incident and continuous phenprocoumon users ≥ 18 years of age using claims data of the statutory health insurance company AOK, covering 30% of the German population...
May 5, 2014: Thrombosis and Haemostasis
Cristina López-Cadenas, Matilde Sierra-Vega, Juan J García-Vieitez, M José Diez-Liébana, Ana Sahagún-Prieto, Nélida Fernández-Martínez
Enrofloxacin is a fluorquinolone exclusively developed for use in veterinary medicine (1980). The kinetics of enrofloxacin are characterized, in general terms, by high bioavailability in most species and rapid absorption after IM, SC or oral administration. However, several studies reported that enrofloxacin showed low bioavailability after oral administration in ruminants. This drug has a broad distribution in the organism, excellent tissue penetration and long serum half-life. Also, enrofloxacin is characterized by a low host toxicity, a broad antibacterial spectrum and high bactericidal activity against major pathogenic bacteria (both Gram-positive and Gram-negative), and intracellular organisms found in diseased animals...
December 2013: Current Drug Metabolism
Barbara C Kahl
Small colony variants (SCVs) of Staphylococcus aureus have been implicated in chronic recurrent infections and have therefore gained renewed interest during the last decade. Moreover, SCVs have been shown to be part of the regular growth cycle, are highly dynamic or stable and can be selected during various harsh conditions. As such, the emergence of SCVs has been described not only in human, but also in veterinary medicine as well as in food microbiology. SCVs are characterized by impaired growth, down-regulation of genes for metabolism and virulence, while sigB and genes important for persistence and biofilm formation are up-regulated...
January 2014: Infection, Genetics and Evolution
W Vahlensieck, M Ludwig, F M E Wagenlehner, K Naber, W Fabry
The prostatitis syndrome is a frequent and complex disease. During the last 40 years the scientific perception has shifted between sometimes success and sometimes disappointment. Whereas acute prostatitis is most frequently considered an infectious disease, in only about 10% of cases with a chronic prostatitis syndrome can pathogens be identified. The bacterial spectrum is similar to that of complicated urinary tract infections with mainly Gram-negative pathogens. In some studies atypical pathogens, such as Chlamydia trachomatis and mycoplasmas, can be found in a considerable proportion...
March 2013: Aktuelle Urologie
Cecilia Sorhouet-Pereira, Adriana Efron, Paula Gagetti, Diego Faccone, Mabel Regueira, Alejandra Corso, Jean-Marc Gabastou, Ana Belén Ibarz-Pavón
Phenotypic and genotypic characterization of 133 isolates of Neisseria meningitidis obtained from meningococcal disease cases in Argentina during 2010 were performed by the National Reference Laboratory as part of a project coordinated by the PAHO within the SIREVA II network. Serogroup, serotype, serosubtype and MLST characterization were performed. Minimum Inhibitory Concentration to penicillin, ampicillin, ceftriaxone, rifampin, chloramphenicol, tetracycline and ciprofloxacin were determined and interpreted according to CLSI guidelines...
2013: PloS One
Anup Kumar Shetty, Ichlampady Nagaraj Shetty, Zevita Venisha Furtado, Beena Antony, Rekha Boloor
BACKGROUND: Enteric fever is caused by the serotypes Salmonella Typhi, Salmonella Paratyphi A, Salmonella Paratyphi B and Salmonella Paratyphi C. After emergence of multidrug resistant Salmonellae Ciprofloxacin, a fluorquinolone antibiotic was the first-line therapy. Treatment failure was observed with Ciprofloxacin soon and such strains showed in-vitro resistance to Nalidixic acid. Recent reports suggest re-emergence of Chloramphenicol sensitive strains and increasing Nalidixic acid resistance...
July 2012: Journal of Laboratory Physicians
M Wehling
Cognitive impairment is a growing problem in aging societies, and dementia is turning into an epidemic. Modifiable conditions are of major interest, as a causal treatment of dementia is still unknown. Drugs represent a major reversible contributor to cognitive deficits and delirium which is seen in 12-50% of elderly in-hospital patients. A third of patients with delirium is being attributed to drugs, and age-related multimorbidity and subsequent polypharmacy are dominant risk factors. The anticholinergic mechanism is not sufficient to explain delirant drug side effects...
October 2012: Der Internist
Laura M Kok, Menno R Bénard, Ewoud R A van Arkel
The combination of fluorquinolones and glucocorticoids leads to a high risk of tendon rupture. Especially the Achilles tendon is at risk. We present a report of a 65-year-old woman with a bilateral Achilles tendon rupture following use of levofloxacin and corticosteroids for pneumonia. Symptoms of the tendons in patients using glucocorticoids and fluorquinolones should be evaluated. The physician should be aware of the high risk of an Achilles tendon rupture, particularly in older patients using this combination...
2012: Nederlands Tijdschrift Voor Geneeskunde
Patricia Bascuñana, Irene Pena, Juan J Picazo, Aurelio C Velasco
C. jejuni as well as some hippurate-negative Campylobacter species and related diarrheagenic organisms, are the leading cause of gastroenteritis in our environment all throughout the year. The aim of the present study was to determine the sensitivity of hippurate-negative Campylobacter and Helicobacter pullorum strains isolated from the stools of patients with diarrhea. We tested 39 Campylobacter coli, two C. lari and five Helicobacter pullorum strains identified by mass spectrometry analysis. The sensitivity to amoxicillin-clavulanic acid, erytrhomycin, azithromycin, gentamicin, ciprofloxacin, levofloxacin, tetracycline, tigecycline and chloramphenicol was tested by E-test...
December 2011: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
T M Polishko, T V Skliar, O V Krysenko, A I Vinnikov, V Ie Kudriavtseva
Among 62 clinical strains of enterobacteria, isolated from intestinal tract, representatives of genus Escherichia made--67.4%, Klebsiella--4.84%, Citrobacter--4.84%, Enterobacter--8.06%, Proteus--6.45%, Morganella of 8.06%. Preparations of fluorquinolone group--gatifloxacin and moxifloxacin, the number of steady strains being from 0.0% to 33.3%, were the most effective in respect of enterobacteria The investigated strains of enterobacteria showed considerable resistance to beta-lactam antibiotics. The highest sensitivity has been noted to cefotaxim: Escherichia spp...
March 2011: Mikrobiolohichnyĭ Zhurnal., Mikrobiologichny Zhurnal
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