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https://www.readbyqxmd.com/read/28070991/a-new-chemmedchem-era
#1
EDITORIAL
David Peralta, Scott D Williams
Moving in medchem: Editors David Peralta and Scott Williams look back at the ChemMedChem 10(th) anniversary celebration in 2016 and introduce exciting developments for the journal in 2017, including the expansion of its scope to nanomedicine, the introduction of Patent Reviews, the addition of new board members, and the publication of special issues related to the expanded scope.
January 5, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28047442/su-f-t-92-clinical-benefit-for-breast-and-chest-wall-setup-in-using-a-breast-board
#2
S Li, C Miyamoto, D Serratore, Q Liang, E Dziemianowicz
PURPOSE: To validate benefit of using a breast board (BB) by analyzing the geometry and dosimetry changes of the regions of interest (ROIs) between CT scans with and without BB. METHODS: Seven patients, two chest walls (CW) and five breasts, use BB at CT simulation and no BB at diagnostic CT were included. By using deformable image registration software (Velocity AI), diagnostic CT and planning CT were rigidly co-registered according to the thoracic cage at the target...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28031978/translational-research-needs-us-to-go-back-to-basics-and-collaborate-interview-with-lars-sundstrom
#3
Lars Sundstrom
Lars Sundstrom is Director of Enterprise and Translation at the West of England Academic Health Sciences Network [1] (UK), a Professor of Practice in Translational Medicine and Co-Director of the Elizabeth Blackwell Institute for Health Research at Bristol University [2] (UK), and an honorary Professor of Medicine at Cardiff University (UK). He has extensive experience in translational medicine and clinical neurosciences, holding positions at several eminent universities. He has also held executive and board-level positions at several SMEs, developing new therapeutics for neurological conditions and tools for drug discovery...
September 2016: Future Science OA
https://www.readbyqxmd.com/read/27999035/impact-of-vancomycin-protein-binding-on-target-attainment-in-critically-ill-children-back-to-the-drawing-board
#4
Pieter A J G De Cock, Sarah Desmet, Annick De Jaeger, Dominique Biarent, Evelyn Dhont, Ingrid Herck, Daphné Vens, Sofie Colman, Veronique Stove, Sabrina Commeyne, Johan Vande Walle, Peter De Paepe
OBJECTIVES: The objectives of this observational study were to investigate plasma protein binding and to evaluate target attainment rates of vancomycin therapy in critically ill children. PATIENTS AND METHODS: Paediatric ICU patients, in whom intravenous intermittent dosing (ID) or continuous dosing (CD) with vancomycin was indicated, were included. Covariates on unbound vancomycin fraction and concentration were tested using a linear mixed model analysis and attainment of currently used pharmacokinetic/pharmacodynamic (PK/PD) targets was evaluated...
December 20, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27983612/health-profile-of-construction-workers-in-hong-kong
#5
Wen Yi, Albert Chan
Construction is a manual, heavy, and complex sector concerning the most fatal accidents and high incidence of occupational illnesses and injuries resulting in days away from work. In Hong Kong, "Pilot Medical Examination Scheme for Construction Workers" was launched in 2014 to detect the health problems of their construction workforce. All registered workers under the Construction Workers Registration Board are eligible to join the scheme. The purpose of this paper is to assess the physical condition, physiological status, and musculoskeletal disorders of 942 construction workers in Hong Kong...
December 13, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27960542/welcome-to-volume-9-of-bioanalysis
#6
Sankeetha Nadarajah
Welcome to volume 9 of Bioanalysis and Happy New Year to all of our readers. We would like to take the opportunity to look back 2016, which was another great year for us. We thank all our authors, readers and reviewers, as well as our Editorial Board members for their continued support. We very much look forward to working with everyone in 2017.
January 2017: Bioanalysis
https://www.readbyqxmd.com/read/27960129/researcher-and-institutional-review-board-perspectives-on-the-benefits-and-challenges-of-reporting-back-biomonitoring-and-environmental-exposure-results
#7
Jennifer Liss Ohayon, Elicia Cousins, Phil Brown, Rachel Morello-Frosch, Julia Green Brody
As the number of personal exposure studies expands and trends favor greater openness and transparency in the health sciences, ethical issues arise around reporting back individual results for contaminants without clear health guidelines. Past research demonstrates that research participants want their results even when the health implications are not known. The experiences of researchers and institutional review boards (IRBs) in studies that have reported personal chemical exposures can provide insights about ethical and practical approaches while also revealing areas of continued uncertainty...
December 10, 2016: Environmental Research
https://www.readbyqxmd.com/read/27935766/dual-source-single-energy-multidetector-ct-used-to-obtain-multiple-radiation-exposure-levels-within-the-same-patient-phantom-development-and-clinical-validation
#8
Davide Bellini, Juan Carlos Ramirez-Giraldo, Alex Bibbey, Justin Solomon, Lynne M Hurwitz, Alfredo Farjat, Achille Mileto, Ehsan Samei, Daniele Marin
Purpose To develop, in a phantom environment, a method to obtain multidetector computed tomographic (CT) data sets at multiple radiation exposure levels within the same patient and to validate its use for potential dose reduction by using different image reconstruction algorithms for the detection of liver metastases. Materials and Methods The American College of Radiology CT accreditation phantom was scanned by using a dual-source multidetector CT platform. By adjusting the radiation output of each tube, data sets at six radiation exposure levels (100%, 75%, 50%, 37...
December 5, 2016: Radiology
https://www.readbyqxmd.com/read/27917380/effect-of-dynamic-temperature-stimulus-to-plantar-surface-of-the-foot-in-the-standing-position
#9
Ryo Watanabe, Hiroyuki Kajimoto
We have previously found that a vertical force or tactile sensation occurs when the temperature of a participant's skin changes rapidly. In this illusion, upward motion, pressure, or force sensation is elicited when stimulus temperature rises rapidly, whereas in the opposite case, downward motion or pulling sensation is elicited. In this paper, we applied this phenomenon to the sole (plantar surface of the foot) to present the sensation of ground slope. To investigate this, we conducted an experiment that measured the correlation between stimulation temperature and front-back direction position of the center of gravity...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27906944/the-safety-of-ct-guided-epidural-steroid-injections-in-an-older-patient-cohort
#10
Andrew J Fenster, Kevin Fernandes, Alan L Brook, Todd Miller
BACKGROUND: Epidural steroid injections (ESIs) are a common method for treating lower back pain, which is one of the most prevalent health-related complaints in the adult US population. Although the safety of CT-guided ESIs has been extensively studied in adults, there is limited data concerning the procedure's safety profile in an older patient population. OBJECTIVE: This retrospective study analyzed safety data among a single-center cohort of patients > 65 years-old who received one or more CT-guided interlaminar ESIs from 2012 to 2015...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27891546/ct-image-quality-in-sinogram-affirmed-iterative-reconstruction-phantom-study-is-there-a-point-of-diminishing-returns
#11
Juan C Infante, Yu Liu, Cynthia K Rigsby
BACKGROUND: In our pediatric practice, we have observed qualitatively limited improvement in the image quality of images generated with sinogram affirmed iterative reconstruction (SAFIRE) compared to series generated with filtered back projection (FBP), particularly in cases near or below a CT dose index volume (CTDIvol) of 1-mGy. OBJECTIVE: To determine whether the image quality advantage of SAFIRE remains constant across clinically used CT dose levels in an American College of Radiology (ACR) CT accreditation phantom including the lower dose range used in pediatric imaging...
November 28, 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27872888/newly-listed-firms-m-a-activities-data-and-their-vc-backing-data
#12
Ting Cao
This article contains hand collected and matched data on the VC investment situation in newly listed firms in SME and ChiNext board from 2009 to 2012 and the corresponding M&A activities data undertaken by these newly listed firms as acquirers in three years following initial public offering. Mentioned data are related to the research article "Heterogeneous Venture Capital, M&A Activity, and Market Response" (W. Li, T. Cao, Z. Feng, 2016) [1].
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27833411/the-impact-of-iterative-reconstruction-in-low-dose-computed-tomography-on-the-evaluation-of-diffuse-interstitial-lung-disease
#13
Hyun-Ju Lim, Myung Jin Chung, Kyung Eun Shin, Hye Sun Hwang, Kyung Soo Lee
OBJECTIVE: To evaluate the impact of iterative reconstruction (IR) on the assessment of diffuse interstitial lung disease (DILD) using CT. MATERIALS AND METHODS: An American College of Radiology (ACR) phantom (module 4 to assess spatial resolution) was scanned with 10-100 effective mAs at 120 kVp. The images were reconstructed using filtered back projection (FBP), adaptive statistical iterative reconstruction (ASIR), with blending ratios of 0%, 30%, 70% and 100%, and model-based iterative reconstruction (MBIR), and their spatial resolution was objectively assessed by the line pair structure method...
November 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/27829573/advancing-interprofessional-primary-health-care-services-in-rural-settings-for-people-with-chronic-low-back-disorders-protocol-of-a-community-based-randomized-controlled-trial
#14
Brenna Bath, Stacey Lovo Grona, Stephan Milosavljevic, Nazmi Sari, Biaka Imeah, Megan E O'Connell
BACKGROUND: Chronic low back disorders (CLBDs) are a substantial burden on individuals and societies, and impact up to 20% of Canadians. Rural and remote residents are approximately 30% more likely to have CLBDs. Reduced access to appropriate team-based health services, including physical therapy, is a key factor that may magnify the impact of CLBD on pain, physical function, overall quality of life, health-related system costs, and individual costs. OBJECTIVE: The purpose of this project is to evaluate the validity, comparative effectiveness, costs, barriers, and facilitators of an interprofessional management approach for people with CLBDs, delivered via telehealth...
November 9, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27798002/-omics-biomarkers-associated-with-chronic-low-back-pain-protocol-of-a-retrospective-longitudinal-study
#15
Massimo Allegri, Manuela De Gregori, Cristina E Minella, Catherine Klersy, Wei Wang, Moira Sim, Christian Gieger, Judith Manz, Iain K Pemberton, Jane MacDougall, Frances Mk Williams, Jan Van Zundert, Klaas Buyse, Gordan Lauc, Ivan Gudelj, Dragan Primorac, Andrea Skelin, Yurii S Aulchenko, Lennart C Karssen, Leonardo Kapural, Richard Rauck, Guido Fanelli
INTRODUCTION: Chronic low back pain (CLBP) produces considerable direct costs as well as indirect burdens for society, industry and health systems. CLBP is characterised by heterogeneity, inclusion of several pain syndromes, different underlying molecular pathologies and interaction with psychosocial factors that leads to a range of clinical manifestations. There is still much to understand in the underlying pathological processes and the non-psychosocial factors which account for differences in outcomes...
October 19, 2016: BMJ Open
https://www.readbyqxmd.com/read/27779723/betalningsviljan-f%C3%A3-r-nya-l%C3%A3-kemedel-bygger-p%C3%A3-etiska-principer-nt-r%C3%A3-det-tolkar-riksdagens-plattform-f%C3%A3-r-prioritering
#16
Jan Liliemark, Lars Lööf, Gustaf Befrits, Stefan Back, Lars Sandman
The County Council's board for new therapies (the NT Council) provides recommendations on the use of new drugs based on the ethical platform of priorities, founded by the Swedish parliament. The Council has formulated a policy that interprets the parliamentary ethical platform and operationalize its need and solidarity principle and cost effectiveness principle in four dimensions. The NT Council weighs the health economic evaluation of the drug and the four dimensions: the severity of the condition, the rarity of the condition, the effect size and the data reliability to determine the willingness to pay level and whether the platform allows a recommendation for using of the drug...
October 18, 2016: Läkartidningen
https://www.readbyqxmd.com/read/27776648/comparison-of-image-quality-and-visibility-of-normal-and-abnormal-findings-at-submillisievert-chest-ct-using-filtered-back-projection-iterative-model-reconstruction-imr-and-idose-4-%C3%A2
#17
COMPARATIVE STUDY
Azien Laqmani, Maxim Avanesov, Sebastian Butscheidt, Maximilian Kurfürst, Susanne Sehner, Jakob Schmidt-Holtz, Thorsten Derlin, Cyrus Behzadi, Hans D Nagel, Gerhard Adam, Marc Regier
OBJECTIVE: To compare both image quality and visibility of normal and abnormal findings at submillisievert chest CT (smSv-CT) using filtered back projection (FBP) and the two different iterative reconstruction (IR) techniques iterative model reconstruction (IMR) and iDose(4)™. MATERIALS AND METHODS: This institutional review board approved study was based on retrospective interpretation of clinically indicated acquired data. The requirement to obtain informed consent was waived...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27768003/the-cost-and-distribution-of-firefighter-injuries-in-a-large-canadian-fire-department
#18
D M Frost, T A C Beach, I Crosby, S M McGill
BACKGROUND: There is limited data available regarding the cost of firefighter injuries. This information is necessary to develop targeted injury prevention strategies. OBJECTIVE: To categorize the cost of injuries filed in 2012 by firefighters from a from a large department by job duty, injury type, body part affected, and the general motion pattern employed at the time of injury. METHODS: Data were taken from reports filed by CFD personnel and claims filed with the Workers' Compensation Board (WCB) of Alberta between January 1, 2012 and December 31, 2012...
November 22, 2016: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/27756318/workers-characteristics-associated-with-the-type-of-healthcare-provider-first-seen-for-occupational-back-pain
#19
Marc-André Blanchette, Michèle Rivard, Clermont E Dionne, Sheilah Hogg-Johnson, Ivan Steenstra
BACKGROUND: Few studies have compared the factors that drive patients' decision to choose a chiropractor, physician or physiotherapist as their first healthcare provider for occupational back pain. The purpose of this study is to identify characteristics associated with the choice of first healthcare provider seen for acute uncomplicated occupational back pain. METHODS: We analyzed data collected by the Workplace Safety and Insurance Board from a cohort of workers with compensated back pain in 2005 in Ontario (Canada)...
October 18, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27755279/open-label-placebo-treatment-in-chronic-low-back-pain-a-randomized-controlled-trial
#20
Cláudia Carvalho, Joaquim Machado Caetano, Lidia Cunha, Paula Rebouta, Ted J Kaptchuk, Irving Kirsch
This randomized controlled trial was performed to investigate whether placebo effects in chronic low back pain could be harnessed ethically by adding open-label placebo (OLP) treatment to treatment as usual (TAU) for 3 weeks. Pain severity was assessed on three 0- to 10-point Numeric Rating Scales, scoring maximum pain, minimum pain, and usual pain, and a composite, primary outcome, total pain score. Our other primary outcome was back-related dysfunction, assessed on the Roland-Morris Disability Questionnaire...
December 2016: Pain
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