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https://www.readbyqxmd.com/read/28647376/mitochondrial-permeability-transition-pore-back-to-the-drawing-board
#1
Christos Chinopoulos
Current models theorizing on what the mitochondrial permeability transition (mPT) pore is made of, implicate the c-subunit rings of ATP synthase complex. However, two very recent studies, one on atomistic simulations and in the other disrupting all genes coding for the c subunit disproved those models. As a consequence of this, the structural elements of the pore remain unknown. The purpose of the present short-review is to (i) briefly review the latest findings, (ii) serve as an index for more comprehensive reviews regarding mPT specifics, (iii) reiterate on the potential pitfalls while investigating mPT in conjunction to bioenergetics, and most importantly (iv) suggest to those in search of mPT pore identity, to also look elsewhere...
June 21, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28643066/solving-the-surgeon-ergonomic-crisis-with-surgical-exosuit
#2
Shanglei Liu, Daniel Hemming, Ran B Luo, Jessica Reynolds, Jonathan C Delong, Bryan J Sandler, Garth R Jacobsen, Santiago Horgan
INTRODUCTION: The widespread adoption of laparoscopic surgery has put new physical demands on the surgeon leading to increased musculoskeletal disorders and injuries. Shoulder, back, and neck pains are among the most common complaints experienced by laparoscopic surgeons. Here, we evaluate the feasibility and efficacy of a non-intrusive progressive arm support exosuit worn by surgeons under the sterile gown to reduce pain and fatigue during surgery. METHODS AND PROCEDURES: This is a prospective randomized crossover study approved by the Internal Review Board (IRB)...
June 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28638840/epidemiology-of-injuries-in-stand-up-paddle-boarding
#3
James Furness, Olayinka Olorunnife, Ben Schram, Mike Climstein, Wayne Hing
BACKGROUND: Stand-up paddle boarding (SUP) is a recreational activity and sport that has grown exponentially, with participation increasing from 1.1 million in 2010 to 2.8 million in 2014 in the United States alone. Despite this growth in participation, SUP remains underresearched with regard to injury epidemiology. PURPOSE: To investigate injury epidemiology (severity, location, type, mechanism) in SUP. STUDY DESIGN: Descriptive epidemiology study...
June 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28582950/the-prevalence-of-work-related-musculoskeletal-disorders-among-sonographers
#4
Tamader Y Al-Rammah, Areej S Aloufi, Saffana K Algaeed, Noura S Alogail
BACKGROUND: Work-related musculoskeletal disorders (WRMSDs) have a significant effect on the psychological and physical function of the sonographer. OBJECTIVE: This study is concerned about finding the prevalence of WRMSDs among sonographers in the Kingdom of Saudi Arabia and assessing how to improve future practices and develop guidelines for safe, pain-free ultrasound departments. METHODS: A survey was distributed to sonographers working in major hospitals in Riyadh, Saudi Arabia (n = 100, 83% response rate)...
June 1, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28582519/x-chromosome-inactivation-in-human-pluripotent-stem-cells-as-a-model-for-human-development-back-to-the-drawing-board
#5
Mieke Geens, Susana M Chuva De Sousa Lopes
BACKGROUND: Human pluripotent stem cells (hPSC), both embryonic and induced (hESC and hiPSC), are regarded as a valuable in vitro model for early human development. In order to fulfil this promise, it is important that these cells mimic as closely as possible the in vivo molecular events, both at the genetic and epigenetic level. One of the most important epigenetic events during early human development is X chromosome inactivation (XCI), the transcriptional silencing of one of the two X chromosomes in female cells...
June 5, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28567609/positive-margins-after-resection-of-metastatic-colorectal-cancer-in-the-liver-back-to-the-drawing-board
#6
EDITORIAL
M I D'Angelica
No abstract text is available yet for this article.
May 31, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28557902/cryopreserved-amniotic-membrane-improves-clinical-outcomes-following-microdiscectomy
#7
D Greg Anderson, Victor Popov, Andrew L Raines, Julie O'Connell
STUDY DESIGN: Prospective, randomized controlled trial. OBJECTIVE: To compare pain, physical/mental functional recovery and recurrent herniation for patients following lumbar microdiscectomy with and without the use of a cryopreserved amniotic tissue graft. SUMMARY OF BACKGROUND DATA: Although microdiscectomy procedures are routinely successful for patients with lumbar radiculopathy due to herniated disc disease, residual low back pain, and recurrent herniation remain unsolved clinical problems...
May 26, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28537348/a-cadaver-study-to-evaluate-the-accuracy-of-a-new-3d-mini-optical-navigation-tool-for-total-hip-arthroplasty
#8
Jonathan M Vigdorchik, Michael B Cross, Eric A Bogner, Theodore T Miller, Jeffrey M Muir, Ran Schwarzkopf
BACKGROUND: Accurate measurement of acetabular cup position (CP), changes in leg length (LL), and offset (OS) are paramount in ensuring proper sizing and implantation of components during total hip arthroplasty (THA). LL/OS inaccuracies can cause low back pain, neurological deficits, and patient dissatisfaction, while inaccurate positioning of the acetabular cup can lead to instability, dislocation, and, ultimately, revision surgery. The objective of this study was to evaluate the accuracy of a mini-navigation tool in measuring CP and LL/OS differential during THA...
May 24, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28507389/bouncing-back-across-the-board-results-of-the-2016-cvma-practice-owners-economic-survey
#9
Chris Doherty
No abstract text is available yet for this article.
May 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28487461/the-impact-of-duty-cycle-workflow-on-sign-out-practices-a-qualitative-study-of-an-internal-medicine-residency-program-in-maryland-usa
#10
Soo-Hoon Lee, Sanjay V Desai, Phillip H Phan
OBJECTIVES: Although JCAHO requires a standardised approach to handoffs, and while many standardised protocols have been tested, sign-out practices continue to vary. We believe this is due to the variability in workflow during inpatient duty cycle. We investigate the impact of such workflows on intern sign-out practices. DESIGN: We employed a prospective, grounded theory mixed-method design. SETTING: The study was conducted at a residency programme in the mid-Atlantic USA...
May 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28471737/mr-elastography-derived-stiffness-a-biomarker-for-intervertebral-disc-degeneration
#11
Benjamin A Walter, Prasath Mageswaran, Xiaokui Mo, Daniel J Boulter, Hazem Mashaly, Xuan V Nguyen, Luciano M Prevedello, William Thoman, Brian D Raterman, Prateek Kalra, Ehud Mendel, William S Marras, Arunark Kolipaka
Purpose To determine the repeatability of magnetic resonance (MR) elastography-derived shear stiffness measurements of the intervertebral disc (IVD) taken throughout the day and their relationship with IVD degeneration and subject age. Materials and Methods In a cross-sectional study, in vivo lumbar MR elastography was performed once in the morning and once in the afternoon in 47 subjects without current low back pain (IVDs = 230; age range, 20-71 years) after obtaining written consent under approval of the institutional review board...
May 4, 2017: Radiology
https://www.readbyqxmd.com/read/28454604/collaboration-guidelines-between-sleep-physicians-and-dentists-in-the-management-of-obstructive-sleep-apnea-an-american-academy-of-dental-sleep-medicine-and-american-academy-of-sleep-medicine-joint-position-statement
#12
Kannan Ramar, James A Rowley, Stuart F Quan, Kathleen M Bennett, Alan Blanton, Kelly A Carden, Ronald D Chervin, Leslie Dort, Douglas B Kirsch, David A Kristo, Mitchell Levine, Raman K Malhotra, Jennifer L Martin, Eric J Olson, Kevin Postol, Ilene M Rosen, Thomas Schell, David Schwartz, Rose Sheats, Harold Smith, Nathaniel F Watson, Terri E Weaver
The boards of directors of the American Academy of Dental Sleep Medicine (AADSM) and the American Academy of Sleep Medicine (AASM) approved this position statement to provide more detailed clarification regarding the appropriate role of dentists and physicians, respectively, in the treatment and ongoing management of obstructive sleep apnea (OSA) using oral appliance therapy (OAT). In order to promote high quality, patient-centered care for patients who have chosen OAT, and to effectively and collaboratively manage these patients, dentists and sleep physicians should follow the recommendations in the updated clinical practice guideline for the treatment of OSA and snoring with OAT, which was published jointly by the AADSM and AASM in 2015...
April 25, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28454511/percutaneous-laser-disc-decompression-versus-conventional-microdiscectomy-for-patients-with-sciatica-two-year-results-of-a-randomised-controlled-trial
#13
Patrick A Brouwer, Ronald Brand, M Elske van den Akker-van Marle, Wilco Ch Jacobs, Barry Schenk, Annette A van den Berg-Huijsmans, Bart W Koes, Mark A Arts, M A van Buchem, Wilco C Peul
Background Percutaneous laser disc decompression is a minimally invasive treatment, for lumbar disc herniation and might serve as an alternative to surgical management of sciatica. In a randomised trial with two-year follow-up we assessed the clinical effectiveness of percutaneous laser disc decompression compared to conventional surgery. Materials and methods This multicentre randomised prospective trial with a non-inferiority design, was carried out according to an intent-to-treat protocol with full institutional review board approval...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28448403/usefulness-of-a-low-tube-voltage-knowledge-based-iterative-model-reconstruction-algorithm-for-computed-tomography-venography
#14
Yuji Iyama, Takeshi Nakaura, Ayumi Iyama, Masafumi Kidoh, Seitaro Oda, Shinichi Tokuyasu, Yasuyuki Yamashita
OBJECTIVES: The objective of this study was to evaluate the use of 80-kVp scans with knowledge-based iterative model reconstruction (IMR) for computed tomography venography (CTV). METHODS: This prospective study received institutional review board approval; a previous informed consent was obtained from all participants. We enrolled 30 patients with suspected deep venous thrombosis or pulmonary embolism who were to undergo 80-kVp CTV studies. The images were reconstructed with filtered back projection (FBP), hybrid iterative reconstruction (HIR), and IMR...
April 26, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28416501/protocol-for-a-placebo-controlled-within-participants-crossover-trial-evaluating-the-efficacy-of-intranasal-oxytocin-to-improve-pain-and-function-among-women-with-chronic-pelvic-musculoskeletal-pain
#15
Joshua A Rash, Kirsti Toivonen, Magali Robert, Maryam Nasr-Esfahani, John F Jarrell, Tavis S Campbell
INTRODUCTION: This protocol presents the rationale and design for a trial evaluating the efficacy of intranasal oxytocin in improving pain and function among women with chronic pelvic musculoskeletal pain. Oxytocin is a neuropeptide traditionally recognised for involvement in labour, delivery and lactation. Novel evidence suggests that oxytocin decreases pain sensitivity in humans. While oxytocin administration has been reported to lower pain sensitivity among patients experiencing chronic back pain, headache, constipation and colon pain, no research has evaluated the association between intranasal oxytocin and chronic pelvic musculoskeletal pain...
April 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28400416/medical-centers-sign-on-to-single-irb-model
#16
(no author information available yet)
All 64 member institutions of the NIH's Clinical and Translational Science Awards program have agreed to a common framework for running multisite trials under the umbrella of just one Institutional Review Board. The NCI has long offered a centralized review board option. Come September, single Institutional Review Boards will be mandatory for all NIH-backed studies.
June 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28390878/protective-effects-of-different-exercise-modalities-in-an-alzheimer-s-disease-like-model
#17
Dilek Özbeyli, Gülce Sarı, Naziye Özkan, Betül Karademir, Meral Yüksel, Özlem Tuğçe Çilingir Kaya, Özgür Kasımay Çakır
Our aim was to investigate the probable protective effects of aerobic, resistance and combined exercise methods on ovariectomy and d-galactose induced Alzheimer's Disease (AD)-like model. d-galactose (100mg/kg) or saline were administered intraperitoneally for 6 weeks to ovariectomized or sham-operated rats (n=8/group). Aerobic (AE), resistance (RE) and combined exercises (CE) (aerobic+resistance) were performed for 3 times a week for 6 weeks. Anxiety level and cognitive functions were evaluated via hole-board and object recognition tests...
April 6, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28374195/pathbot-a-radiology-pathology-correlation-dashboard
#18
Linda C Kelahan, Amit D Kalaria, Ross W Filice
Pathology is considered the "gold standard" of diagnostic medicine. The importance of radiology-pathology correlation is seen in interdepartmental patient conferences such as "tumor boards" and by the tradition of radiology resident immersion in a radiologic-pathology course at the American Institute of Radiologic Pathology. In practice, consistent pathology follow-up can be difficult due to time constraints and cumbersome electronic medical records. We present a radiology-pathology correlation dashboard that presents radiologists with pathology reports matched to their dictations, for both diagnostic imaging and image-guided procedures...
April 3, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28373333/small-decline-in-low-value-back-imaging-associated-with-the-choosing-wisely-campaign-2012-14
#19
Arthur S Hong, Dennis Ross-Degnan, Fang Zhang, J Frank Wharam
Choosing Wisely was launched by the American Board of Internal Medicine in April 2012 as a patient- and clinician-targeted campaign to reduce potentially unnecessary "low-value" medical services. The campaign's impact on low- and high-value care beyond its first year is unknown; furthermore, it is unknown whether some patients such as members of consumer-directed health plans and people residing in different US regions have responded more than others. To evaluate the impact of Choosing Wisely, we used commercial insurance claims to track changes in the use of low-value imaging (x-ray, computed tomography, and magnetic resonance imaging) for back pain before and after the campaign began, a period running from 2010 to 2014...
April 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28339444/a-review-of-long-term-pain-relief-after-genicular-nerve-radiofrequency-ablation-in-chronic-knee-osteoarthritis
#20
Ferdinand Iannaccone, Samuel Dixon, Andrew Kaufman
BACKGROUND: Studies of radiofrequency ablation (RFA) of genicular nerves have reportedly significantly decreased pain up to 3 months post ablation, but no longer term effects have been reported. We performed an analysis of long-term pain relief of 31 RFA procedures of the genicular nerves to analyze the degree of pain relief past 3 months, culminating at 6 months. STUDY DESIGN: Chart review and study design was approved by Newark Health Sciences Institutional Review Board (IRB)...
March 2017: Pain Physician
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