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https://www.readbyqxmd.com/read/29341857/development-of-visibility-forecasting-modelling-framework-for-the-lower-fraser-valley-of-british-columbia-using-canada-s-regional-air-quality-deterministic-prediction-system
#1
Rita So, Andrew Teakles, Jonathan Baik, Roxanne Vingarzan, Keith Jones
Visibility degradation, one of the most noticeable indicators of poor air quality, can occur despite relatively low levels of particulate matter when the risk to human health is low. The availability of timely and reliable visibility forecasts can provide a more comprehensive understanding of the anticipated air quality conditions to better inform local jurisdictions and the public. This paper describes the development of a visibility forecasting modelling framework, which leverages the existing air quality and meteorological forecasts from Canada's operational Regional Air Quality Deterministic Prediction System (RAQDPS) for the Lower Fraser Valley of British Columbia...
January 17, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29341417/synthesis-and-characterization-of-photoactivatable-doxycycline-analogues-bearing-two-photon-sensitive-photoremovable-groups-suitable-for-light-induced-gene-expression
#2
Alexandre Specht, Bastien Goegan, Firat Terzi, Frédéric Bolze, Sidney Cambridge
We report herein the synthesis and the photolytic properties of EANBP and PEG7-DEACM caged 9-aminodoxycycline. 9-Aminodoxycycline is a tetracycline analogue able to activate transcription via the inducible TetOn transgene expression system and can be regioselectively coupled by carbamoylation to two-photon sensitive photoremovable protecting groups. The EANBP caged 9-aminodoxycycline showed complex photochemical reactions but did release 10% of 9-aminodoxycycline. However, the PEG7-DEACM-9-aminodoxycycline exhibited excellent photolysis efficiency at 405 nm with a quantitative release of 9-aminodoxycycline and a 0...
January 17, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29340940/characterizing-potentially-preventable-admissions-a-mixed-methods-study-of-rates-associated-factors-outcomes-and-physician-decision-making
#3
Lisa M Daniels, Atsushi Sorita, Deanne T Kashiwagi, Masashi Okubo, Evan Small, Eric C Polley, Adam P Sawatsky
BACKGROUND: Potentially preventable admissions are a target for healthcare cost containment. OBJECTIVE: To identify rates of, characterize associations with, and explore physician decision-making around potentially preventable admissions. DESIGN: A comparative cohort study was used to determine rates of potentially preventable admissions and to identify associated factors and patient outcomes. A qualitative case study was used to explore physicians' clinical decision-making...
January 16, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29340885/quantifying-diastolic-function-from-e-waves-as-triangles-to-physiologic-contours-via-the-geometric-method
#4
Mikhail Golman, William Padovano, Leonid Shmuylovich, Sándor J Kovács
Conventional echocardiographic diastolic function (DF) assessment approximates transmitral flow velocity contours (Doppler E-waves) as triangles, with peak (Epeak), acceleration time (AT), and deceleration time (DT) as indexes. These metrics have limited value because they are unable to characterize the underlying physiology. The parametrized diastolic filling (PDF) formalism provides a physiologic, kinematic mechanism based characterization of DF by extracting chamber stiffness (k), relaxation (c), and load (x o ) from E-wave contours...
January 16, 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29340061/analysis-of-the-mutational-landscape-of-classic-hodgkin-lymphoma-identifies-disease-heterogeneity-and-potential-therapeutic-targets
#5
Elena Mata, Antonio Díaz-López, Ana M Martín-Moreno, Margarita Sánchez-Beato, Ignacio Varela, María J Mestre, Carlos Santonja, Fernando Burgos, Javier Menárguez, Mónica Estévez, Mariano Provencio, Beatriz Sánchez-Espiridión, Eva Díaz, Carlos Montalbán, Miguel A Piris, Juan F García
Defining the mutational landscape of classic Hodgkin lymphoma is still a major research goal. New targeted next-generation sequencing (NGS) techniques may identify pathogenic mechanisms and new therapeutic opportunities related to this disease. We describe the mutational profile of a series of 57 cHL cases, enriched in Hodgkin and Reed-Sternberg (HRS) cells. Overall, the results confirm the presence of strong genomic heterogeneity. However, several variants were consistently detected in genes related to relevant signaling pathways, such as GM-CSF/IL-3, CBP/EP300, JAK/STAT, NF-kappaB, and numerous variants of genes affecting the B-cell receptor (BCR) pathway, such as BTK, CARD11, BCL10, among others...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29338593/expression-and-role-of-granulocyte-macrophage-colony-stimulating-factor-receptor-gm-csfr-and-granulocyte-colony-stimulating-factor-receptor-g-csfr-on-ph-positive-acute-b-lymphoblastic-leukemia
#6
Yong Wu, Ming Tan, Mei-Ling Chen, Yuan-Zhong Chen
OBJECTIVE: We observed that ph + ALL patients administrated with recombinant human G-CSF (rhG-CSF) after intense chemotherapy have presented a trend of disease relapse. Thus, we aim to thoroughly investigate the expression and role of GM-CSFR and G-CSFR on ph + ALL patients. METHOD: SUP-B15, BALL-1 and primary leukemia cells were used in this study. Transcript levels were analyzed by quantitative PCR while cell viability was measured using a CCK-8 assay...
January 17, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29338160/higher-activities-of-hepatic-versus-splenic-cd8-t-cells-in-responses-to-adoptive-t-cell-therapy-and-vaccination-of-b6-mice-with-mhc-class-1-binding-antigen
#7
Mohamed Labib Salem, Randa E El Naggar, Sabry A El Naggar, Maysa A Mobasher, Mohamed H Mahmoud, Gamal Badr
The liver has unique microenvironment which is known to induce tolerance of cytolytic CD8+ T cells to hepatic and extra hepatic antigens, resulting in persistence of infection of the liver by the hepatitis B and C viruses. However, under some conditions, functional immune responses can be elicited in the liver in particular to show preferential retention of activated CD8+ T cells. It is not clear whether this retention depends on the type of the exogenous immunostimulatory or the endogenous innate immune cells...
December 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29337228/monitoring-the-prevalence-of-genetically-modified-gm-maize-in-iran-food-products
#8
Motahreh Sadat Hosseini, Gilda Eslami, Bahador Hajimohammadi, Hossein Fallahzadeh, Zahra Derakhshan, Gea Oliveri Conti, Margherita Ferrante
Maize, the second most important genetically modified (GM) crop, and an ingredient in many foodstuffs worldwide. Regulations for both the labeling and the traceability of GMOs in feed chains are coming into force worldwide. To provide consumer's information, labelling for food products containing more than 0.9% of GM material is demanded by the actual EU legislation. Analysis of foods is then essential to detect and quantify GM maize material and verify the compliance with labelling information. For this purpose, reliable and accurate detection methods are a necessity...
January 11, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29336777/presence-of-apoptosis-distinguishes-primary-central-nervous-system-lymphoma-from-glioblastoma-during-intraoperative-consultation
#9
Yoon Jin Cha, Junjeong Choi, Se Hoon Kim
AIM: To evaluate the overlapping and distinguishing cytologic features of primary central nervous system lymphoma (PCNSL), diffuse large B-cell lymphoma, and glioblastoma (GM) in frozen sections and squash smear slides. MATERIALS AND METHODS: Intraoperative frozen sections and squash smear slides from PCNSL (N = 63) and GM (N = 122) patients diagnosed from 2005 to 2015 were retrieved from pathology records. Overlapping and distinguishing histologic features were examined and statistically analyzed...
January 16, 2018: Clinical Neuropathology
https://www.readbyqxmd.com/read/29335889/comparison-of-gray-matter-volume-between-migraine-and-strict-criteria-tension-type-headache
#10
Wei-Ta Chen, Kun-Hsien Chou, Pei-Lin Lee, Fu-Jung Hsiao, David M Niddam, Kuan-Lin Lai, Jong-Ling Fuh, Ching-Po Lin, Shuu-Jiun Wang
BACKGROUND: Despite evidently distinct symptoms, tension-type headache (TTH) and migraine are highly comorbid and exhibit many similarities in clinical practice. The purpose of this study was to investigate whether both types of headaches are similar in brain morphology. METHODS: Consecutive patients with TTH and age- and sex-matched patients with migraine and healthy controls were enrolled for brain magnetic resonance imaging examination. Patients with TTH were excluded if they reported any headache features or associated symptoms of migraine...
January 15, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29335496/localization-and-function-of-neurosecretory-protein-gm-a-novel-small-secretory-protein-in-the-chicken-hypothalamus
#11
Kenshiro Shikano, Yuki Bessho, Masaki Kato, Eiko Iwakoshi-Ukena, Shusuke Taniuchi, Megumi Furumitsu, Tetsuya Tachibana, George E Bentley, Lance J Kriegsfeld, Kazuyoshi Ukena
Recently, we discovered a novel cDNA encoding the precursor of a small secretory protein, neurosecretory protein GL (NPGL), in the hypothalamic infundibulum of chickens. NPGL plays an important role in the regulation of growth and feeding. A database search indicated that the NPGL gene has a paralogous gene: neurosecretory protein GM (NPGM), also in chickens. We identified cDNA encoding the NPGM precursor in chickens. Morphological analysis showed that NPGM-containing cells are specifically localized in the medial mammillary nucleus (MM) and infundibular nucleus (IN) in the hypothalamus...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29333407/the-limited-role-of-serum-galactomannan-assay-in-screening-for-invasive-pulmonary-aspergillosis-in-allogeneic-stem-cell-transplantation-recipients-on-micafungin-prophylaxis-a-retrospective-study
#12
Ryul Kim, Youngil Koh, Dong-Yeop Shin, Pyoeng Gyun Choe, Nam Joong Kim, Sung-Soo Yoon, Myoung-Don Oh, Wan Beom Park, Inho Kim
Background: We evaluated the outcomes of serum galactomannan (GM) assay for the screening of invasive pulmonary aspergillosis (IPA) in allogeneic hematopoietic stem cell transplantation (alloHSCT) recipients while on primary antifungal prophylaxis (PAP). Methods: This study included patients with hematologic disorders who underwent alloHSCT from January 2013 to November 2015. Patients received routine PAP with fluconazole before 2014 and micafungin after 2014; serum GM tests were performed and retrospectively analyzed...
December 2017: Blood Research
https://www.readbyqxmd.com/read/29332740/an-electromyographic-analysis-of-selected-asana-in-experienced-yogic-practitioners
#13
Kathleen Kelley, Katherine Slattery, Kaitlyn Apollo
The purpose of this study was to assess electromyographic (EMG) output of the anterior tibialis (TA), medial head of the gastrocnemius (GA), rectus femoris (RF), bicep femoris (BF), and gluteus medius (GM) in experienced yogic practitioners during selected yoga asana. A secondary purpose was to examine the differences in EMG output in unilateral V. bilateral standing yoga asana. The study was a single occasion descriptive design. Thirteen healthy yoga practitioners (1 male, 12 females, average age of 37.5) with more than five years of experience were recruited...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29332372/measurement-and-modeling-of-indoor-radon-concentrations-in-residential-buildings
#14
Ji Hyun Park, Sungim Whang, Hyun Young Lee, Cheol-Min Lee, Dae Ryong Kang
Objectives: Radon, the primary constituent of natural radiation, is the second leading environmental cause of lung cancer after smoking. To confirm a relationship between indoor radon exposure and lung cancer, estimating cumulative levels of exposure to indoor radon for an individual or population is necessary. This study sought to develop a model for estimate indoor radon concentrations in Korea. Especially, our model and method may have wider application to other residences, not to specific site, and can be used in situations where actual measurements for input variables are lacking...
January 8, 2018: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/29331092/deep-grey-matter-volume-loss-drives-disability-worsening-in-multiple-sclerosis
#15
Arman Eshaghi, Ferran Prados, Wallace Brownlee, Daniel R Altmann, Carmen Tur, M Jorge Cardoso, Floriana De Angelis, Steven H van de Pavert, Niamh Cawley, Nicola De Stefano, M Laura Stromillo, Marco Battaglini, Serena Ruggieri, Claudio Gasperini, Massimo Filippi, Maria A Rocca, Alex Rovira, Jaume Sastre-Garriga, Hugo Vrenken, Cyra E Leurs, Joep Killestein, Lukas Pirpamer, Christian Enzinger, Sebastien Ourselin, Claudia A M Gandini Wheeler-Kingshott, Declan Chard, Alan J Thompson, Daniel C Alexander, Frederik Barkhof, Olga Ciccarelli
OBJECTIVE: Grey matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with faster disability accumulation in MS. METHODS: We analysed 3,604 brain high-resolution T1-weighted MRI scans from 1,417 participants: 1,214 MS patients (253 clinically-isolated syndrome[CIS], 708 relapsing-remitting[RRMS], 128 secondary-progressive[SPMS], 125 primary-progressive[PPMS]), over an average follow-up of 2...
January 13, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29329199/pressure-induced-densification-and-compression-in-a-reprocessed-borosilicate-glass
#16
Kathryn J Ham, Yoshio Kono, Parimal J Patel, Steven M Kilczewski, Yogesh K Vohra
Pressure induced densification and compression of a reprocessed sample of borosilicate glass has been studied by X-ray radiography and energy dispersive X-ray diffraction using a Paris-Edinburgh (PE) press at a synchrotron X-ray source. The reprocessing of a commercial borosilicate glass was carried out by cyclical melting and cooling. Gold foil pressure markers were used to obtain the sample pressure by X-ray diffraction using its known equation of state, while X-ray radiography provided a direct measure of the sample volume at high pressure...
January 12, 2018: Materials
https://www.readbyqxmd.com/read/29329055/altered-brain-structure-in-women-with-premenstrual-syndrome
#17
Peng Liu, Ying Wei, Yingying Fan, Ru Li, Yanfei Liu, Geliang Wang, Yichen Wei, Yong Pang, Demao Deng, Wei Qin
BACKGROUND: Functional brain abnormalities have been noted in premenstrual syndrome (PMS). However, the brain structural alterations related to PMS remain unclear. This study aimed to identify possible abnormalities in gray matter (GM) volumes and structural covariance patterns among PMS patients. METHODS: Structural magnetic resonance imaging data were obtained from 20 PMS patients and 20 healthy controls. Voxel-based morphometry (VBM) analysis was applied to examine GM volumes changes between the two groups...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29328910/modulation-of-myelopoiesis-progenitors-is-an-integral-component-of-trained-immunity
#18
Ioannis Mitroulis, Klara Ruppova, Baomei Wang, Lan-Sun Chen, Michal Grzybek, Tatyana Grinenko, Anne Eugster, Maria Troullinaki, Alessandra Palladini, Ioannis Kourtzelis, Antonios Chatzigeorgiou, Andreas Schlitzer, Marc Beyer, Leo A B Joosten, Berend Isermann, Mathias Lesche, Andreas Petzold, Kai Simons, Ian Henry, Andreas Dahl, Joachim L Schultze, Ben Wielockx, Nicola Zamboni, Peter Mirtschink, Ünal Coskun, George Hajishengallis, Mihai G Netea, Triantafyllos Chavakis
Trained innate immunity fosters a sustained favorable response of myeloid cells to a secondary challenge, despite their short lifespan in circulation. We thus hypothesized that trained immunity acts via modulation of hematopoietic stem and progenitor cells (HSPCs). Administration of β-glucan (prototypical trained-immunity-inducing agonist) to mice induced expansion of progenitors of the myeloid lineage, which was associated with elevated signaling by innate immune mediators, such as IL-1β and granulocyte-macrophage colony-stimulating factor (GM-CSF), and with adaptations in glucose metabolism and cholesterol biosynthesis...
January 11, 2018: Cell
https://www.readbyqxmd.com/read/29328541/gm-csf-ameliorates-micro-vascular-barrier-integrity-via-pericytes-derived-ang-1-in-wound-healing
#19
Min Yan, Yange Hu, Min Yao, Shisan Bao, Yong Fang
BACKGROUND: Skin wound healing involves complex coordinated interactions of cells, tissues and mediators. Maintaining microvascular barrier integrity is one of the key events for endothelial homeostasis during wound healing. Vasodilation is observed after vasoconstriction, which causes blood vessels to become porous, facilitates leukocyte infiltration and aids angiogenesis at the wound-area, post-injury. Eventually, vessel integrity has to be re-established for vascular maturation. Numerous studies have found that granulocyte macrophage colony-stimulating factor (GM-CSF) accelerates wound healing by inducing recruitment of repair cells into the injury area and releases of cytokines...
January 12, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29327177/influence-of-sampling-frequency-and-load-calculation-methods-on-quantification-of-annual-river-nutrient-and-suspended-solids-loads
#20
Ahmed Elwan, Ranvir Singh, Maree Patterson, Jon Roygard, Dave Horne, Brent Clothier, Geoffrey Jones
Better management of water quality in streams, rivers and lakes requires precise and accurate estimates of different contaminant loads. We assessed four sampling frequencies (2 days, weekly, fortnightly and monthly) and five load calculation methods (global mean (GM), rating curve (RC), ratio estimator (RE), flow-stratified (FS) and flow-weighted (FW)) to quantify loads of nitrate-nitrogen (NO3--N), soluble inorganic nitrogen (SIN), total nitrogen (TN), dissolved reactive phosphorus (DRP), total phosphorus (TP) and total suspended solids (TSS), in the Manawatu River, New Zealand...
January 11, 2018: Environmental Monitoring and Assessment
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