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Rebecca De Lorenzo, Iago Pinal-Fernandez, Wilson Huang, Jemima Albayda, Eleni Tiniakou, Cheilonda Johnson, Jose C Milisenda, Maria Casal-Dominguez, Andrea M Corse, Sonye K Danoff, Lisa Christopher-Stine, Julie J Paik, Andrew L Mammen
OBJECTIVE: To define the clinical features of myositis patients with anti-PM/Scl-75 and/or anti-PM/Scl-100 autoantibodies at disease onset and during the course of disease and compare them to patients with other forms of myositis. METHODS: In this longitudinal cohort study, the prevalence and severity of clinical features at disease onset and during follow-up were compared between anti-PM/Scl-positive patients and those with the antisynthetase syndrome (AS), dermatomyositis (DM), and immune-mediated necrotizing myopathy (IMNM)...
May 4, 2018: Neurology
Theran P Riedel, David M DeMarini, Jose Zavala, Sarah H Warren, Eric W Corse, John H Offenberg, Tadeusz E Kleindienst, Michael Lewandowski
Although many volatile organic compounds (VOCs) are regulated to limit air pollution and the consequent health effects, the photooxidation products generally are not. Thus, we examined the mutagenicity in Salmonella TA100 of photochemical atmospheres generated in a steady-state atmospheric simulation chamber by irradiating mixtures of single aromatic VOCs, NOx , and ammonium sulfate seed aerosol in air. The 10 VOCs examined were benzene; toluene; ethylbenzene; o -, m -, and p -xylene; 1,2,4- and 1,3,5-trimethylbenzene; m -cresol; and naphthalene...
April 2018: Atmospheric Environment
Carole Ehrhardt, Quentin Boucherie, Vanessa Pauly, David Braunstein, Eléonore Ronflé, Xavier Thirion, Elisabeth Frauger, Joelle Micallef
OBJECTIVE: Methylphenidate (MPH) is a prescription-stimulant medication which is authorized in France for two indications: attention-deficit hyperactivity disorder in children (aged≥6years) and narcolepsy in cases where modafinil is ineffective (for children and adults). MPH use has increased worldwide in the past 2 decades in children and adults. Different pharmacoepidemiological Europeans studies have described MPH patterns of use. To our knowledge, few pharmacoepidemiological studies have described MPH patterns of use in France...
December 2017: Thérapie
Veena Krishnamoorthy, Sunil Kannanganat, Mark Maienschein-Cline, Sarah L Cook, Jianjun Chen, Neil Bahroos, Evelyn Sievert, Emily Corse, Anita Chong, Roger Sciammas
Transcriptional regulation during CD4+ T cell fate decisions enables their differentiation into distinct states, guiding immune responses toward antibody production via Tfh cells or inflammation by Teff cells. Tfh-Teff cell fate commitment is regulated by mutual antagonism between the transcription factors Bcl6 and Blimp-1. Here we examined how T cell receptor (TCR) signals establish and arbitrate Bcl6-Blimp-1 counter-antagonism. We found that the TCR-signal-induced transcription factor Irf4 is essential for the differentiation of Bcl6-expressing Tfh and Blimp-1-expressing Teff cells...
September 19, 2017: Immunity
Jemima Albayda, Aamna Khan, Livia Casciola-Rosen, Andrea M Corse, Julie J Paik, Lisa Christopher-Stine
OBJECTIVE: In the context of clinical evaluations performed on our prospective myositis cohort, we noted a striking association of severe cardiac disease in myositis patients with anti-mitochondrial antibodies. We sought to review all cases of anti-mitochondrial antibody (AMA) associated myositis in our cohort to describe the clinical features of this disease subset. METHODS: We identified 7 patients with confirmed anti-mitochondrial antibodies who presented as an inflammatory myopathy...
February 2018: Seminars in Arthritis and Rheumatism
Laura Morbidoni, Massimiliano Correani, Marco Candela
INTRODUCTION: Few evidences about methods to harvest educational needs by health care professionals in internal medicine have been published. In this project the following objectives have been pursued: to express preferences by each health care worker; to evaluate the efficacy of an intranet-based survey in order to structure continuing medical education (CME) planning. METHODS: We created a form based on 7 questions, exploring the following areas: knowledge, know-how, communication, transversal competencies...
July 2017: Recenti Progressi in Medicina
Emmanuel Corse, Emese Meglécz, Gaït Archambaud, Morgane Ardisson, Jean-François Martin, Christelle Tougard, Rémi Chappaz, Vincent Dubut
The main objective of this work was to develop and validate a robust and reliable "from-benchtop-to-desktop" metabarcoding workflow to investigate the diet of invertebrate-eaters. We applied our workflow to faecal DNA samples of an invertebrate-eating fish species. A fragment of the cytochrome c oxidase I (COI) gene was amplified by combining two minibarcoding primer sets to maximize the taxonomic coverage. Amplicons were sequenced by an Illumina MiSeq platform. We developed a filtering approach based on a series of nonarbitrary thresholds established from control samples and from molecular replicates to address the elimination of cross-contamination, PCR/sequencing errors and mistagging artefacts...
August 4, 2017: Molecular Ecology Resources
M Fabre-Grenet, P Garcia-Méric, V Bernard-Niel, V Guagliardo, S Cortaredona, M Aymeric-Ponsonnet
AIMS: The link between deformational plagiocephaly and psychomotor development is a recurrent question in medical publications. Main publications concentrate on term infants, but there is a lack of data on the impact of deformational plagiocephaly on the long-term neurodevelopment of premature infants. We attempted to establish a possible relation between deformational plagiocephaly during the 1st year of life and the psychomotor score at 4 years in prematurely born infants. Other risk factors potentially impacting the psychomotor score were also studied...
July 25, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Marie-Céline Casaurancq, Emilie Patras de Campaigno, Manuela Rueter, Bérangère Baricault, Robert Bourrel, Maryse Lapeyre-Mestre, Agnès Sommet
AIM: This article proposes a description of French regional consumption of antibiotics with a bacterial resistance risk (amoxicillin+clavulanic acid, third-generation cephalosporins [C3G] and fluoroquinolones). METHODS: Antibiotics reimbursements data were obtained by Open Medic website. The antibiotic consumption profile has been established using some indicators of the European Surveillance of Antimicrobial Consumption (ESAC) in daily-defined dose per 1000 inhabitants per day (DID) or in percentage...
October 2017: Thérapie
Julie J Paik, Fredrick M Wigley, Ami A Shah, Andrea M Corse, Livia Casciola-Rosen, Laura K Hummers, Andrew L Mammen
OBJECTIVE: To determine if a unique subtype of scleroderma muscle disease exists by comparing the clinical features of systemic sclerosis (SSc; scleroderma) patients with predominant fibrosis on muscle biopsy to those with inflammatory muscle histopathology. METHODS: This retrospective, cross-sectional study included SSc patients with muscle weakness and an available muscle biopsy. Biopsies with fibrosis but without inflammation/necrosis were designated as "fibrosing myopathy," and those with inflammation and/or necrosis were assigned a category of "inflammatory myopathy...
November 2017: Arthritis Care & Research
David R Amici, Iago Pinal-Fernandez, Davi A G Mázala, Thomas E Lloyd, Andrea M Corse, Lisa Christopher-Stine, Andrew L Mammen, Eva R Chin
Sporadic inclusion body myositis (IBM) is the most common primary myopathy in the elderly, but its pathoetiology is still unclear. Perturbed myocellular calcium (Ca2+ ) homeostasis can exacerbate many of the factors proposed to mediate muscle degeneration in IBM, such as mitochondrial dysfunction, protein aggregation, and endoplasmic reticulum stress. Ca2+ dysregulation may plausibly be initiated in IBM by immune-mediated membrane damage and/or abnormally accumulating proteins, but no studies to date have investigated Ca2+ regulation in IBM patients...
March 22, 2017: Acta Neuropathologica Communications
James F Howard, Miriam Freimer, Fanny O'Brien, Jing Jing Wang, Stephen R Collins, John T Kissel
INTRODUCTION: A phase 2 study of eculizumab for treating myasthenia gravis (MG) used the quantitative myasthenia gravis score (QMG) and myasthenia gravis activities of daily living profile (MG-ADL) to evaluate baseline disease severity and treatment response. Correlations were then analyzed between these assessments. METHODS: Patients were given eculizumab or placebo during the first 16-week treatment period of the crossover study, with treatment assignments reversed for the second treatment period following a 5-week washout...
August 2017: Muscle & Nerve
Teija Corse, Chelsea Firth, John Burke, Kenneth Schor, James F Koterski, Sabrina McGraw, Nancy Vincent-Johnson, Lori Gordon
Operation Canine Lifeline was a tabletop exercise developed by students and faculty of Boston University School of Medicine's Healthcare Emergency Management master's program. The tabletop exercise led to discussion on current protocols for canines working in the field, what occurs if a canine encounters a toxin in the field, and what to do in situations of national security that require working with civilian agencies. This discussion led to the creation of a set of recommendations around providing prehospital veterinary care to government working dogs...
February 2017: Disaster Medicine and Public Health Preparedness
Fikret E Kapucu, Inkeri Välkki, Jarno E Mikkonen, Chiara Leone, Kerstin Lenk, Jarno M A Tanskanen, Jari A K Hyttinen
Synchrony and asynchrony are essential aspects of the functioning of interconnected neuronal cells and networks. New information on neuronal synchronization can be expected to aid in understanding these systems. Synchronization provides insight in the functional connectivity and the spatial distribution of the information processing in the networks. Synchronization is generally studied with time domain analysis of neuronal events, or using direct frequency spectrum analysis, e.g., in specific frequency bands...
2016: Frontiers in Computational Neuroscience
Darin D Dougherty, Tina Chou, Andrew K Corse, Amanda R Arulpragasam, Alik S Widge, Cristina Cusin, Karleyton C Evans, Benjamin D Greenberg, Suzanne N Haber, Thilo Deckersbach
OBJECTIVE Deep brain stimulation (DBS) is a reversible, nonlesion-based treatment for patients with intractable obsessive-compulsive disorder (OCD). The first studies on DBS for OCD stimulating the ventral capsule/ventral striatum (VC/VS) yielded encouraging results for this neuroanatomical site's therapeutic efficacy. This investigation was conducted to better understand which regions of the cortico-striatal-thalamic-cortical network were acutely affected by VC/VS DBS for OCD. Furthermore, the objective was to identify which brain regions demonstrated changes in perfusion, as stimulation was applied across a dorsoventral lead axis that corresponded to different anatomical locations in the VC/VS...
February 19, 2016: Journal of Neurosurgery
Ted M Burns, Gordon A Smith, Jeffrey A Allen, Anthony A Amato, W David Arnold, Richard Barohn, Michael Benatar, Shawn J Bird, Mark Bromberg, Nizar Chahin, Emma Ciafaloni, Jeffrey A Cohen, Andrea Corse, Brian A Crum, William S David, Elliot Dimberg, Eduardo A De Sousa, Peter D Donofrio, P James B Dyck, Andrew G Engel, Erik R Ensrud, Mark Ferrante, Miriam Freimer, Karissa L Gable, Summer Gibson, James M Gilchrist, Jonathan M Goldstein, Clifton L Gooch, Brent P Goodman, Dmitri Gorelov, Sidney M Gospe, Namita A Goyal, Amanda C Guidon, Jeffrey T Guptill, Laurie Gutmann, Ludwig Gutmann, Kelly Gwathmey, Yadollah Harati, C Michel Harper, Michael K Hehir, Lisa D Hobson-Webb, James F Howard, Carlayne E Jackson, Nicholas Johnson, Sarah M Jones, Vern C Juel, Henry J Kaminski, Chafic Karam, Kathleen D Kennelly, Sami Khella, Julie Khoury, John C Kincaid, John T Kissel, Noah Kolb, David Lacomis, Shafeeq Ladha, Daniel Larriviere, Richard A Lewis, Yuebing Li, William J Litchy, Eric Logigian, Jau-Shin Lou, Daniel J L MacGowen, Ricardo Maselli, Janice M Massey, Michelle L Mauermann, Katherine D Mathews, Matthew N Meriggioli, Robert G Miller, Joon-Shik Moon, Tahseen Mozaffar, Sharon P Nations, Richard J Nowak, Lyle W Ostrow, Robert M Pascuzzi, Amanda Peltier, Katherine Ruzhansky, David P Richman, Mark A Ross, Devon I Rubin, James A Russell, George M Sachs, Mohammad Kian Salajegheh, David S Saperstein, Stephen Scelsa, Duygu Selcen, Aziz Shaibani, Perry B Shieh, Nicholas J Silvestri, J Rob Singleton, Benn E Smith, Yuen T So, Guillermo Solorzano, Eric J Sorenson, Jayashri Srinivasen, Jinny Tavee, Rabi Tawil, Pariwat Thaisetthawatkul, Charles Thornton, Jaya Trivedi, Steven Vernino, Annabel K Wang, Tyler A Webb, Michael D Weiss, Anthony J Windebank, Gil I Wolfe
No abstract text is available yet for this article.
February 2016: Muscle & Nerve
Emmanuel Corse, Nicolas Pech, Melthide Sinama, Caroline Costedoat, Rémi Chappaz, André Gilles
Understanding the impact of non-native species on native species is a major challenge in molecular ecology, particularly for genetically compatible fish species. Invasions are generally difficult to study because their effects may be confused with those of environmental or human disturbances. Colonized ecosystems are differently impacted by human activities, resulting in diverse responses and interactions between native and non-native species. We studied the dynamics between two Cyprinids species (invasive Chondrostoma nasus and endemic Parachondrostoma toxostoma) and their hybrids in 16 populations (from allopatric to sympatric situations and from little to highly fragmented areas) corresponding to 2,256 specimens...
2015: PloS One
Iago Pinal-Fernandez, Livia A Casciola-Rosen, Lisa Christopher-Stine, Andrea M Corse, Andrew L Mammen
OBJECTIVE: Individual dermatomyositis (DM)-associated autoantibodies are associated with distinct clinical phenotypes. This study was undertaken to explore the association of these autoantibodies with specific muscle biopsy features. METHODS: DM subjects with a muscle biopsy reviewed at Johns Hopkins had sera screened for autoantibodies recognizing Mi-2, transcriptional intermediary factor 1-γ (TIF1-γ), NXP2, MDA5, Ro52, PM-Scl, and Jo1. We also included anti-Jo1–positive patients with polymyositis (PM) who had a biopsy read at Johns Hopkins...
August 2015: Journal of Rheumatology
Alik S Widge, Ernesto Licon, Samuel Zorowitz, Andrew Corse, Amanda R Arulpragasam, Joan A Camprodon, Cristina Cusin, Emad N Eskandar, Thilo Deckersbach, Darin D Dougherty
Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a novel therapy for neuropsychiatric disorders. Hypomania is a known complication of VC/VS DBS, but who is at risk is less understood. Factors such as family history, combined with details of DBS programming, might quantify that risk. The authors performed an iterative modeling procedure on a VC/VS DBS patient registry to identify key predictors. Hypomania was less common for men and for patients stimulated on the ventral right contact...
2016: Journal of Neuropsychiatry and Clinical Neurosciences
Rachel Franklin, Sam Zorowitz, Andrew K Corse, Alik S Widge, Thilo Deckersbach
Bipolar disorder (BD) is a debilitating and difficult-to-treat psychiatric disease that presents a serious burden to patients' lives as well as health care systems around the world. The essential diagnostic criterion for BD is episodes of mania or hypomania; however, the patients report that the majority of their time is spent in a depressive phase. Current treatment options for this component of BD have yet to achieve satisfactory remission rates. Lurasidone is a drug in the benzisothiazole class approved by the US Food and Drug Administration in June 2013 for the acute treatment of bipolar depression...
2015: Neuropsychiatric Disease and Treatment
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