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Darin D Dougherty, Tina Chou, Andrew K Corse, Amanda R Arulpragasam, Alik S Widge, Cristina Cusin, Karleyton C Evans, Benjamin D Greenberg, Suzanne N Haber, Thilo Deckersbach
OBJECTIVE Deep brain stimulation (DBS) is a reversible, nonlesion-based treatment for patients with intractable obsessive-compulsive disorder (OCD). The first studies on DBS for OCD stimulating the ventral capsule/ventral striatum (VC/VS) yielded encouraging results for this neuroanatomical site's therapeutic efficacy. This investigation was conducted to better understand which regions of the cortico-striatal-thalamic-cortical network were acutely affected by VC/VS DBS for OCD. Furthermore, the objective was to identify which brain regions demonstrated changes in perfusion, as stimulation was applied across a dorsoventral lead axis that corresponded to different anatomical locations in the VC/VS...
February 19, 2016: Journal of Neurosurgery
Ted M Burns, Gordon A Smith, Jeffrey A Allen, Anthony A Amato, W David Arnold, Richard Barohn, Michael Benatar, Shawn J Bird, Mark Bromberg, Nizar Chahin, Emma Ciafaloni, Jeffrey A Cohen, Andrea Corse, Brian A Crum, William S David, Elliot Dimberg, Eduardo A De Sousa, Peter D Donofrio, P James B Dyck, Andrew G Engel, Erik R Ensrud, Mark Ferrante, Miriam Freimer, Karissa L Gable, Summer Gibson, James M Gilchrist, Jonathan M Goldstein, Clifton L Gooch, Brent P Goodman, Dmitri Gorelov, Sidney M Gospe, Namita A Goyal, Amanda C Guidon, Jeffrey T Guptill, Laurie Gutmann, Ludwig Gutmann, Kelly Gwathmey, Yadollah Harati, C Michel Harper, Michael K Hehir, Lisa D Hobson-Webb, James F Howard, Carlayne E Jackson, Nicholas Johnson, Sarah M Jones, Vern C Juel, Henry J Kaminski, Chafic Karam, Kathleen D Kennelly, Sami Khella, Julie Khoury, John C Kincaid, John T Kissel, Noah Kolb, David Lacomis, Shafeeq Ladha, Daniel Larriviere, Richard A Lewis, Yuebing Li, William J Litchy, Eric Logigian, Jau-Shin Lou, Daniel J L MacGowen, Ricardo Maselli, Janice M Massey, Michelle L Mauermann, Katherine D Mathews, Matthew N Meriggioli, Robert G Miller, Joon-Shik Moon, Tahseen Mozaffar, Sharon P Nations, Richard J Nowak, Lyle W Ostrow, Robert M Pascuzzi, Amanda Peltier, Katherine Ruzhansky, David P Richman, Mark A Ross, Devon I Rubin, James A Russell, George M Sachs, Mohammad Kian Salajegheh, David S Saperstein, Stephen Scelsa, Duygu Selcen, Aziz Shaibani, Perry B Shieh, Nicholas J Silvestri, J Rob Singleton, Benn E Smith, Yuen T So, Guillermo Solorzano, Eric J Sorenson, Jayashri Srinivasen, Jinny Tavee, Rabi Tawil, Pariwat Thaisetthawatkul, Charles Thornton, Jaya Trivedi, Steven Vernino, Annabel K Wang, Tyler A Webb, Michael D Weiss, Anthony J Windebank, Gil I Wolfe
No abstract text is available yet for this article.
February 2016: Muscle & Nerve
Emmanuel Corse, Nicolas Pech, Melthide Sinama, Caroline Costedoat, Rémi Chappaz, André Gilles
Understanding the impact of non-native species on native species is a major challenge in molecular ecology, particularly for genetically compatible fish species. Invasions are generally difficult to study because their effects may be confused with those of environmental or human disturbances. Colonized ecosystems are differently impacted by human activities, resulting in diverse responses and interactions between native and non-native species. We studied the dynamics between two Cyprinids species (invasive Chondrostoma nasus and endemic Parachondrostoma toxostoma) and their hybrids in 16 populations (from allopatric to sympatric situations and from little to highly fragmented areas) corresponding to 2,256 specimens...
2015: PloS One
Iago Pinal-Fernandez, Livia A Casciola-Rosen, Lisa Christopher-Stine, Andrea M Corse, Andrew L Mammen
OBJECTIVE: Individual dermatomyositis (DM)-associated autoantibodies are associated with distinct clinical phenotypes. This study was undertaken to explore the association of these autoantibodies with specific muscle biopsy features. METHODS: DM subjects with a muscle biopsy reviewed at Johns Hopkins had sera screened for autoantibodies recognizing Mi-2, transcriptional intermediary factor 1-γ (TIF1-γ), NXP2, MDA5, Ro52, PM-Scl, and Jo1. We also included anti-Jo1–positive patients with polymyositis (PM) who had a biopsy read at Johns Hopkins...
August 2015: Journal of Rheumatology
Alik S Widge, Ernesto Licon, Samuel Zorowitz, Andrew Corse, Amanda R Arulpragasam, Joan A Camprodon, Cristina Cusin, Emad N Eskandar, Thilo Deckersbach, Darin D Dougherty
Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a novel therapy for neuropsychiatric disorders. Hypomania is a known complication of VC/VS DBS, but who is at risk is less understood. Factors such as family history, combined with details of DBS programming, might quantify that risk. The authors performed an iterative modeling procedure on a VC/VS DBS patient registry to identify key predictors. Hypomania was less common for men and for patients stimulated on the ventral right contact...
2016: Journal of Neuropsychiatry and Clinical Neurosciences
Rachel Franklin, Sam Zorowitz, Andrew K Corse, Alik S Widge, Thilo Deckersbach
Bipolar disorder (BD) is a debilitating and difficult-to-treat psychiatric disease that presents a serious burden to patients' lives as well as health care systems around the world. The essential diagnostic criterion for BD is episodes of mania or hypomania; however, the patients report that the majority of their time is spent in a depressive phase. Current treatment options for this component of BD have yet to achieve satisfactory remission rates. Lurasidone is a drug in the benzisothiazole class approved by the US Food and Drug Administration in June 2013 for the acute treatment of bipolar depression...
2015: Neuropsychiatric Disease and Treatment
Christine Í Dali, Norman W Barton, Mohamed H Farah, Mihai Moldovan, Jan-Eric Månsson, Nitin Nair, Morten Dunø, Lotte Risom, Hongmei Cao, Luying Pan, Marcia Sellos-Moura, Andrea M Corse, Christian Krarup
OBJECTIVE: Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disorder due to deficient activity of arylsulfatase A (ASA) that causes accumulation of sulfatide and lysosulfatide. The disorder is associated with demyelination and axonal loss in the central and peripheral nervous systems. The late infantile form has an early-onset, rapidly progressive course with severe sensorimotor dysfunction. The relationship between the degree of nerve damage and (lyso)sulfatide accumulation is, however, not established...
May 2015: Annals of Clinical and Translational Neurology
Julie J Paik, Fredrick M Wigley, Thomas E Lloyd, Andrea M Corse, Livia Casciola-Rosen, Ami A Shah, Francesco Boin, Laura K Hummers, Andrew L Mammen
OBJECTIVE: To determine if distinct muscle pathologic features exist in scleroderma subjects with weakness. METHODS: This retrospective study included weak scleroderma subjects with muscle biopsies available for review. Biopsies were systematically assessed for individual pathologic features, including inflammation, necrosis, fibrosis, and acute neurogenic atrophy. Based on the aggregate individual features, biopsies were assigned a histopathologic category of polymyositis, dermatomyositis, necrotizing myopathy, nonspecific myositis, "acute denervation," "fibrosis only," or "other...
October 2015: Arthritis Care & Research
Ricardo H Roda, Alice B Schindler, Craig Blackstone, Andrew L Mammen, Andrea M Corse, Thomas E Lloyd
Mutations in MYH7 cause autosomal dominant Laing distal myopathy. We present a family with a previously reported deletion (c.5186_5188delAGA, p.K1729del). Muscle pathology in one family member was characterized by an inflammatory myopathy with rimmed vacuoles, increased MHC Class I expression, and perivascular and endomysial muscle inflammation comprising CD3(+), CD4(+), CD8(+), and CD68(+) inflammatory cells. Interestingly, this biopsy specimen contained TDP-43, p62, and SMI-31-positive protein aggregates typical of inclusion body myositis...
December 2014: Annals of Clinical and Translational Neurology
Safa Al-Sarraj, Andrew King, Matt Cleveland, Pierre-François Pradat, Andrea Corse, Jeffrey D Rothstein, Peter Nigel Leigh, Bams Abila, Stewart Bates, Jens Wurthner, Vincent Meininger
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a primary progressive neurodegenerative disease characterised by neuronal loss of lower motor neurons (in the spinal cord and brainstem) and/or upper motor neurons (in the motor cortex) and subsequent denervation atrophy of skeletal muscle. AIM: A comprehensive examination of muscle pathology from a cohort of clinically confirmed ALS patients, including an investigation of inflammation, complement activation, and deposition of abnormal proteins in order to compare them with findings from an age-matched, control group...
2014: Acta Neuropathologica Communications
René Richet, Yury G Verves, Daniel Whitmore, Thomas Pape
The identity of the nominal taxon Taxigramma pseudaperta Séguy, 1941 [type locality: France, Corse] is revised and an improved circumscription based partly on reared material of both sexes is presented through comparison with the very similar and sympatric species T. multipunctata (Rondani, 1859). A table is provided to separate first instars, puparia, males and females of these two taxa.
2013: Zootaxa
Demetrio Sierra-Mercado, Thilo Deckersbach, Amanda R Arulpragasam, Tina Chou, Alexandra M Rodman, Amanda Duffy, Eric J McDonald, Christine A Eckhardt, Andrew K Corse, Navneet Kaur, Emad N Eskandar, Darin D Dougherty
Decision making in both animals and humans is influenced by the anticipation of reward and/or punishment. Little is known about how reward and punishment interact in the context of decision making. The Avoidance-Reward Conflict (ARC) Task is a new paradigm that varies the degree of reward and the probability of punishment in a single paradigm that can be used in both non-human primates (NHPs) and humans. This study examined the behavioral pattern in the ARC task in both NHPs and humans. Two adult male NHPs (macaca mulatta) and 20 healthy human volunteers (12 females) participated in the ARC task...
September 2015: Brain Structure & Function
Marion Bessone, Pascal Rathelot, Raffi Agopian, Sylvie Pracchia, Etienne Schmitt, Patrice Pascual, Manon Roche, Riana Rasamison, Christophe Curti, Marc Montana, Patrice Vanelle, Véronique Pelissier, Aline Mousnier
PURPOSES: A new methodology to evaluate the medication-use system based on a risk cartography tool, has been developed. This work has been promoted by the Observatoire du médicament et des dispositifs médicaux stériles et de l'innovation thérapeutique (OMEDIT) from Provence-Alpes-Côte d'Azur (PACA)-Corse regions. METHODS: This new methodology has been developed with Excel (Microsoft(®)) and has led to the mediEVAL tool. It consists in two categories of Excel files: evaluating Excel files (1 for each job of the medication-use system) and synthesis Excel files which allow to compile a group of evaluating files for a defined area (department, hospital…)...
May 2014: Thérapie
Sylvie Bonin-Guillaume, Gaëlle Martin, Joseline Zafack, Gaétan Gentile, Véronique Allaria-Lapierre, Vincent Sciortino, Xavier Thirion, Joëlle Micallef
AIM: The aim of the study was to identify and to characterize patients with Alzheimer's disease or related dementia describing antipsychotics and other psychotropic expositions. METHODS: The study was performed, in 2010, based on Provence-Alpes-Côte d'Azur region (PACA)-Corse Alz cohort included patients with dementia, with chronic condition 'Alzheimer disease or related disease' and/or had at least one delivery of Alzheimer's specific treatment, registered in the General Health Care System...
May 2014: Thérapie
Vincent Meininger, Pierre-François Pradat, Andrea Corse, Safa Al-Sarraj, Benjamin Rix Brooks, James B Caress, Merit Cudkowicz, Stephen J Kolb, Dale Lange, P Nigel Leigh, Thomas Meyer, Stefano Milleri, Karen E Morrison, Richard W Orrell, Gary Peters, Jeffrey D Rothstein, Jeremy Shefner, Arseniy Lavrov, Nicola Williams, Phil Overend, Jeffrey Price, Stewart Bates, Jonathan Bullman, David Krull, Alienor Berges, Bams Abila, Guy Meno-Tetang, Jens Wurthner
UNLABELLED: The neurite outgrowth inhibitor, Nogo-A, has been shown to be overexpressed in skeletal muscle in amyotrophic lateral sclerosis (ALS); it is both a potential biomarker and therapeutic target. We performed a double-blind, two-part, dose-escalation study, in subjects with ALS, assessing safety, pharmacokinetics (PK) and functional effects of ozanezumab, a humanized monoclonal antibody against Nogo-A. In Part 1, 40 subjects were randomized (3∶1) to receive single dose intravenous ozanezumab (0...
2014: PloS One
F Alauzet, M-C Banide, C Pailhes, S Blanc, I Montaudié, C Piccini-Bailly, M Berlioz-Baudoin, M Bégassat, M Albertini, L Giovannini-Chami
CONTEXT AND AIM: Guidelines have been published regularly since 2010 by the ANSM (the Health Products Safety Agency) advising against antitussive drugs for infants because of their inefficacy and their side effects (convulsions, respiratory congestion). Antihistamines, mucolytics, and terpene-based suppositories have theoretically disappeared from infant pharmacopoeia. We assessed the degree of compliance with these guidelines on the part of health professionals. MATERIALS AND METHODS: From June 2012 to August 2012, 198 general practitioners and 44 pediatricians were assessed in the Alpes-Maritimes department of France by means of questionnaires...
May 2014: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
M Romano, I Pontikaki, M Gattinara, I Ardoino, C Donati, P Boracchi, P L Meroni, V Gerloni
The objective of this study was to determine long-term effectiveness and safety of 1st biological treatment (BT) in a cohort of 301 juvenile idiopathic arthritis (JIA) patients (pts), non-responders to disease-modifying antirheumatic drugs (DMARDs), in terms of drug survival (continuation rate on therapy) and to identify the baseline predictors of treatment discontinuation. Each JIA pt enrolled in BT is prospectively assessed at the start of treatment and then every 2 months for the evaluation of safety and efficacy according to ACR-Pedi30 criteria...
2013: Reumatismo
Julie J Paik, Andrea M Corse, Andrew L Mammen
OBJECTIVE: Myositis and myasthenia gravis (MG) are both autoimmune disorders presenting with muscle weakness. Rarely, they occur simultaneously in the same patient. Since the management of myasthenia gravis differs from that of myositis, it is important to recognize when patients have both diseases. We reviewed the cases of 6 patients with both myositis and MG to identify clinical features that suggest the possibility of co-existing MG in myositis patients. METHODS: We identified 6 patients with dermatomyositis or polymyositis and MG...
June 2014: Seminars in Arthritis and Rheumatism
M Kamínek, V Pačes, J Corse, J S Challice
The cytokinin activities of cis and trans ribosylzeatin isomers and that of N(6)-(Δ(2)-isopentenyl)adenosine were compared in four bioassays. The trans isomer was found to be more active than the cis isomer in stimulation of cucumber cotyledon expansion (100x), retention of chlorophyll in detached leaf pieces (7x), induction and stimulation of chlorophyll synthesis in cucumber cotyledons (20x) and of betacyanin synthesis in Amaranthus caudatus seedlings grown in the dark (60x). The N(6)-(Δ(2)-isopentenyl)adenosine adenosine was less active than the trans ribosylzeatin in all four bioassays and more active than the cis ribosylzeatin in induction and stimulation of betacyanin and chlorophyll synthesis...
January 1979: Planta
Hemlata Varsani, Susan C Charman, Charles K Li, Suely K N Marie, Anthony A Amato, Brenda Banwell, Kevin E Bove, Andrea M Corse, Alison M Emslie-Smith, Thomas S Jacques, Ingrid E Lundberg, Carlo Minetti, Inger Nennesmo, Elisabeth J Rushing, Adriana M E Sallum, Caroline Sewry, Clarissa A Pilkington, Janice L Holton, Lucy R Wedderburn
OBJECTIVES: To study muscle biopsy tissue from patients with juvenile dermatomyositis (JDM) in order to test the reliability of a score tool designed to quantify the severity of histological abnormalities when applied to biceps humeri in addition to quadriceps femoris. Additionally, to evaluate whether elements of the tool correlate with clinical measures of disease severity. METHODS: 55 patients with JDM with muscle biopsy tissue and clinical data available were included...
January 2015: Annals of the Rheumatic Diseases
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