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Emmanuel Corse, Emese Meglécz, Gaït Archambaud, Morgane Ardisson, Jean-François Martin, Christelle Tougard, Rémi Chappaz, Vincent Dubut
The main objective of this work was to develop and validate a robust and reliable 'from benchtop-to-desktop' metabarcoding workflow to investigate the diet of invertebrate-eaters. We applied our workflow to fecal DNA samples of an invertebrate-eating fish species. A fragment of the COI gene was amplified by combining two minibarcoding primer sets to maximize the taxonomic coverage. Amplicons were sequenced by an Illumina MiSeq platform. We developed a filtering approach based on a series of non-arbitrary thresholds established from control samples and from molecular replicates in order to address the elimination of cross-contamination, PCR/sequencing errors and mistagging artifacts...
August 4, 2017: Molecular Ecology Resources
M Fabre-Grenet, P Garcia-Méric, V Bernard-Niel, V Guagliardo, S Cortaredona, M Aymeric-Ponsonnet
AIMS: The link between deformational plagiocephaly and psychomotor development is a recurrent question in medical publications. Main publications concentrate on term infants, but there is a lack of data on the impact of deformational plagiocephaly on the long-term neurodevelopment of premature infants. We attempted to establish a possible relation between deformational plagiocephaly during the 1st year of life and the psychomotor score at 4 years in prematurely born infants. Other risk factors potentially impacting the psychomotor score were also studied...
July 25, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Marie-Céline Casaurancq, Emilie Patras de Campaigno, Manuela Rueter, Bérangère Baricault, Robert Bourrel, Maryse Lapeyre-Mestre, Agnès Sommet
AIM: This article proposes a description of French regional consumption of antibiotics with a bacterial resistance risk (amoxicillin+clavulanic acid, third-generation cephalosporins [C3G] and fluoroquinolones). METHODS: Antibiotics reimbursements data were obtained by Open Medic website. The antibiotic consumption profile has been established using some indicators of the European Surveillance of Antimicrobial Consumption (ESAC) in daily-defined dose per 1000 inhabitants per day (DID) or in percentage...
May 26, 2017: Thérapie
Julie J Paik, Fredrick M Wigley, Ami A Shah, Andrea M Corse, Livia Casciola-Rosen, Laura K Hummers, Andrew L Mammen
OBJECTIVE: To determine if a unique subtype of scleroderma muscle disease exists by comparing the clinical features of systemic sclerosis (SSc) patients with predominant fibrosis on muscle biopsy to those with inflammatory muscle histopathology. METHODS: This retrospective, cross-sectional study included SSc patients with muscle weakness and an available muscle biopsy. Biopsies with fibrosis but without inflammation/necrosis were designated as "fibrosing myopathy" and those with inflammation and/or necrosis were assigned a category of "inflammatory myopathy"...
May 23, 2017: Arthritis Care & Research
David R Amici, Iago Pinal-Fernandez, Davi A G Mázala, Thomas E Lloyd, Andrea M Corse, Lisa Christopher-Stine, Andrew L Mammen, Eva R Chin
Sporadic inclusion body myositis (IBM) is the most common primary myopathy in the elderly, but its pathoetiology is still unclear. Perturbed myocellular calcium (Ca(2+)) homeostasis can exacerbate many of the factors proposed to mediate muscle degeneration in IBM, such as mitochondrial dysfunction, protein aggregation, and endoplasmic reticulum stress. Ca(2+) dysregulation may plausibly be initiated in IBM by immune-mediated membrane damage and/or abnormally accumulating proteins, but no studies to date have investigated Ca(2+) regulation in IBM patients...
March 22, 2017: Acta Neuropathologica Communications
James F Howard, Miriam Freimer, Fanny O'Brien, Jing Jing Wang, Stephen R Collins, John T Kissel
INTRODUCTION: A phase 2 study of eculizumab for treating myasthenia gravis (MG) used the quantitative myasthenia gravis score (QMG) and myasthenia gravis activities of daily living profile (MG-ADL) to evaluate baseline disease severity and treatment response. Correlations were then analyzed between these assessments. METHODS: Patients were given eculizumab or placebo during the first 16-week treatment period of the crossover study, with treatment assignments reversed for the second treatment period following a 5-week washout...
August 2017: Muscle & Nerve
Teija Corse, Chelsea Firth, John Burke, Kenneth Schor, James F Koterski, Sabrina McGraw, Nancy Vincent-Johnson, Lori Gordon
Operation Canine Lifeline was a tabletop exercise developed by students and faculty of Boston University School of Medicine's Healthcare Emergency Management master's program. The tabletop exercise led to discussion on current protocols for canines working in the field, what occurs if a canine encounters a toxin in the field, and what to do in situations of national security that require working with civilian agencies. This discussion led to the creation of a set of recommendations around providing prehospital veterinary care to government working dogs...
December 15, 2016: Disaster Medicine and Public Health Preparedness
Fikret E Kapucu, Inkeri Välkki, Jarno E Mikkonen, Chiara Leone, Kerstin Lenk, Jarno M A Tanskanen, Jari A K Hyttinen
Synchrony and asynchrony are essential aspects of the functioning of interconnected neuronal cells and networks. New information on neuronal synchronization can be expected to aid in understanding these systems. Synchronization provides insight in the functional connectivity and the spatial distribution of the information processing in the networks. Synchronization is generally studied with time domain analysis of neuronal events, or using direct frequency spectrum analysis, e.g., in specific frequency bands...
2016: Frontiers in Computational Neuroscience
Darin D Dougherty, Tina Chou, Andrew K Corse, Amanda R Arulpragasam, Alik S Widge, Cristina Cusin, Karleyton C Evans, Benjamin D Greenberg, Suzanne N Haber, Thilo Deckersbach
OBJECTIVE Deep brain stimulation (DBS) is a reversible, nonlesion-based treatment for patients with intractable obsessive-compulsive disorder (OCD). The first studies on DBS for OCD stimulating the ventral capsule/ventral striatum (VC/VS) yielded encouraging results for this neuroanatomical site's therapeutic efficacy. This investigation was conducted to better understand which regions of the cortico-striatal-thalamic-cortical network were acutely affected by VC/VS DBS for OCD. Furthermore, the objective was to identify which brain regions demonstrated changes in perfusion, as stimulation was applied across a dorsoventral lead axis that corresponded to different anatomical locations in the VC/VS...
February 19, 2016: Journal of Neurosurgery
Ted M Burns, Gordon A Smith, Jeffrey A Allen, Anthony A Amato, W David Arnold, Richard Barohn, Michael Benatar, Shawn J Bird, Mark Bromberg, Nizar Chahin, Emma Ciafaloni, Jeffrey A Cohen, Andrea Corse, Brian A Crum, William S David, Elliot Dimberg, Eduardo A De Sousa, Peter D Donofrio, P James B Dyck, Andrew G Engel, Erik R Ensrud, Mark Ferrante, Miriam Freimer, Karissa L Gable, Summer Gibson, James M Gilchrist, Jonathan M Goldstein, Clifton L Gooch, Brent P Goodman, Dmitri Gorelov, Sidney M Gospe, Namita A Goyal, Amanda C Guidon, Jeffrey T Guptill, Laurie Gutmann, Ludwig Gutmann, Kelly Gwathmey, Yadollah Harati, C Michel Harper, Michael K Hehir, Lisa D Hobson-Webb, James F Howard, Carlayne E Jackson, Nicholas Johnson, Sarah M Jones, Vern C Juel, Henry J Kaminski, Chafic Karam, Kathleen D Kennelly, Sami Khella, Julie Khoury, John C Kincaid, John T Kissel, Noah Kolb, David Lacomis, Shafeeq Ladha, Daniel Larriviere, Richard A Lewis, Yuebing Li, William J Litchy, Eric Logigian, Jau-Shin Lou, Daniel J L MacGowen, Ricardo Maselli, Janice M Massey, Michelle L Mauermann, Katherine D Mathews, Matthew N Meriggioli, Robert G Miller, Joon-Shik Moon, Tahseen Mozaffar, Sharon P Nations, Richard J Nowak, Lyle W Ostrow, Robert M Pascuzzi, Amanda Peltier, Katherine Ruzhansky, David P Richman, Mark A Ross, Devon I Rubin, James A Russell, George M Sachs, Mohammad Kian Salajegheh, David S Saperstein, Stephen Scelsa, Duygu Selcen, Aziz Shaibani, Perry B Shieh, Nicholas J Silvestri, J Rob Singleton, Benn E Smith, Yuen T So, Guillermo Solorzano, Eric J Sorenson, Jayashri Srinivasen, Jinny Tavee, Rabi Tawil, Pariwat Thaisetthawatkul, Charles Thornton, Jaya Trivedi, Steven Vernino, Annabel K Wang, Tyler A Webb, Michael D Weiss, Anthony J Windebank, Gil I Wolfe
No abstract text is available yet for this article.
February 2016: Muscle & Nerve
Emmanuel Corse, Nicolas Pech, Melthide Sinama, Caroline Costedoat, Rémi Chappaz, André Gilles
Understanding the impact of non-native species on native species is a major challenge in molecular ecology, particularly for genetically compatible fish species. Invasions are generally difficult to study because their effects may be confused with those of environmental or human disturbances. Colonized ecosystems are differently impacted by human activities, resulting in diverse responses and interactions between native and non-native species. We studied the dynamics between two Cyprinids species (invasive Chondrostoma nasus and endemic Parachondrostoma toxostoma) and their hybrids in 16 populations (from allopatric to sympatric situations and from little to highly fragmented areas) corresponding to 2,256 specimens...
2015: PloS One
Iago Pinal-Fernandez, Livia A Casciola-Rosen, Lisa Christopher-Stine, Andrea M Corse, Andrew L Mammen
OBJECTIVE: Individual dermatomyositis (DM)-associated autoantibodies are associated with distinct clinical phenotypes. This study was undertaken to explore the association of these autoantibodies with specific muscle biopsy features. METHODS: DM subjects with a muscle biopsy reviewed at Johns Hopkins had sera screened for autoantibodies recognizing Mi-2, transcriptional intermediary factor 1-γ (TIF1-γ), NXP2, MDA5, Ro52, PM-Scl, and Jo1. We also included anti-Jo1–positive patients with polymyositis (PM) who had a biopsy read at Johns Hopkins...
August 2015: Journal of Rheumatology
Alik S Widge, Ernesto Licon, Samuel Zorowitz, Andrew Corse, Amanda R Arulpragasam, Joan A Camprodon, Cristina Cusin, Emad N Eskandar, Thilo Deckersbach, Darin D Dougherty
Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a novel therapy for neuropsychiatric disorders. Hypomania is a known complication of VC/VS DBS, but who is at risk is less understood. Factors such as family history, combined with details of DBS programming, might quantify that risk. The authors performed an iterative modeling procedure on a VC/VS DBS patient registry to identify key predictors. Hypomania was less common for men and for patients stimulated on the ventral right contact...
2016: Journal of Neuropsychiatry and Clinical Neurosciences
Rachel Franklin, Sam Zorowitz, Andrew K Corse, Alik S Widge, Thilo Deckersbach
Bipolar disorder (BD) is a debilitating and difficult-to-treat psychiatric disease that presents a serious burden to patients' lives as well as health care systems around the world. The essential diagnostic criterion for BD is episodes of mania or hypomania; however, the patients report that the majority of their time is spent in a depressive phase. Current treatment options for this component of BD have yet to achieve satisfactory remission rates. Lurasidone is a drug in the benzisothiazole class approved by the US Food and Drug Administration in June 2013 for the acute treatment of bipolar depression...
2015: Neuropsychiatric Disease and Treatment
Christine Í Dali, Norman W Barton, Mohamed H Farah, Mihai Moldovan, Jan-Eric Månsson, Nitin Nair, Morten Dunø, Lotte Risom, Hongmei Cao, Luying Pan, Marcia Sellos-Moura, Andrea M Corse, Christian Krarup
OBJECTIVE: Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disorder due to deficient activity of arylsulfatase A (ASA) that causes accumulation of sulfatide and lysosulfatide. The disorder is associated with demyelination and axonal loss in the central and peripheral nervous systems. The late infantile form has an early-onset, rapidly progressive course with severe sensorimotor dysfunction. The relationship between the degree of nerve damage and (lyso)sulfatide accumulation is, however, not established...
May 2015: Annals of Clinical and Translational Neurology
Julie J Paik, Fredrick M Wigley, Thomas E Lloyd, Andrea M Corse, Livia Casciola-Rosen, Ami A Shah, Francesco Boin, Laura K Hummers, Andrew L Mammen
OBJECTIVE: To determine if distinct muscle pathologic features exist in scleroderma subjects with weakness. METHODS: This retrospective study included weak scleroderma subjects with muscle biopsies available for review. Biopsies were systematically assessed for individual pathologic features, including inflammation, necrosis, fibrosis, and acute neurogenic atrophy. Based on the aggregate individual features, biopsies were assigned a histopathologic category of polymyositis, dermatomyositis, necrotizing myopathy, nonspecific myositis, "acute denervation," "fibrosis only," or "other...
October 2015: Arthritis Care & Research
Ricardo H Roda, Alice B Schindler, Craig Blackstone, Andrew L Mammen, Andrea M Corse, Thomas E Lloyd
Mutations in MYH7 cause autosomal dominant Laing distal myopathy. We present a family with a previously reported deletion (c.5186_5188delAGA, p.K1729del). Muscle pathology in one family member was characterized by an inflammatory myopathy with rimmed vacuoles, increased MHC Class I expression, and perivascular and endomysial muscle inflammation comprising CD3(+), CD4(+), CD8(+), and CD68(+) inflammatory cells. Interestingly, this biopsy specimen contained TDP-43, p62, and SMI-31-positive protein aggregates typical of inclusion body myositis...
December 2014: Annals of Clinical and Translational Neurology
Safa Al-Sarraj, Andrew King, Matt Cleveland, Pierre-François Pradat, Andrea Corse, Jeffrey D Rothstein, Peter Nigel Leigh, Bams Abila, Stewart Bates, Jens Wurthner, Vincent Meininger
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a primary progressive neurodegenerative disease characterised by neuronal loss of lower motor neurons (in the spinal cord and brainstem) and/or upper motor neurons (in the motor cortex) and subsequent denervation atrophy of skeletal muscle. AIM: A comprehensive examination of muscle pathology from a cohort of clinically confirmed ALS patients, including an investigation of inflammation, complement activation, and deposition of abnormal proteins in order to compare them with findings from an age-matched, control group...
2014: Acta Neuropathologica Communications
René Richet, Yury G Verves, Daniel Whitmore, Thomas Pape
The identity of the nominal taxon Taxigramma pseudaperta Séguy, 1941 [type locality: France, Corse] is revised and an improved circumscription based partly on reared material of both sexes is presented through comparison with the very similar and sympatric species T. multipunctata (Rondani, 1859). A table is provided to separate first instars, puparia, males and females of these two taxa.
2013: Zootaxa
Demetrio Sierra-Mercado, Thilo Deckersbach, Amanda R Arulpragasam, Tina Chou, Alexandra M Rodman, Amanda Duffy, Eric J McDonald, Christine A Eckhardt, Andrew K Corse, Navneet Kaur, Emad N Eskandar, Darin D Dougherty
Decision making in both animals and humans is influenced by the anticipation of reward and/or punishment. Little is known about how reward and punishment interact in the context of decision making. The Avoidance-Reward Conflict (ARC) Task is a new paradigm that varies the degree of reward and the probability of punishment in a single paradigm that can be used in both non-human primates (NHPs) and humans. This study examined the behavioral pattern in the ARC task in both NHPs and humans. Two adult male NHPs (macaca mulatta) and 20 healthy human volunteers (12 females) participated in the ARC task...
September 2015: Brain Structure & Function
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