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https://www.readbyqxmd.com/read/29915626/novel-surgical-treatments-for-gastroesophageal-reflux-disease-systematic-review-of-magnetic-sphincter-augmentation-and-electric-stimulation-therapy
#1
REVIEW
Michal Stanak, Judit Erdos, Katharina Hawlik, Tudor Birsan
Electric stimulation therapy (EST) and magnetic sphincter augmentation (MSA) represent novel methods for the surgical treatment of gastroesophageal reflux disease (GERD). The aim of this review was to assess the effectiveness and safety of EST and magnetic sphincter augmentation device (MSAD) comapred to laparoscopic fundoplication (LF) and proton pump inhibitor therapy (in case of EST). We performed a systematic literature search without restrictions on publication dates in five electronic databases (MEDLINE, EMBASE, the Cochrane library, PubMed, and Centre for Reviews and Dissemination), complemented by hand search, search in trial registries, and documentation provided by the manufacturers...
June 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29915158/diagnosis-and-management-of-gastroesophageal-reflux-in-preterm-infants
#2
Eric C Eichenwald
Gastroesophageal reflux (GER), generally defined as the passage of gastric contents into the esophagus, is an almost universal phenomenon in preterm infants. It is a common diagnosis in the NICU; however, there is large variation in its treatment across NICU sites. In this clinical report, the physiology, diagnosis, and symptomatology in preterm infants as well as currently used treatment strategies in the NICU are examined. Conservative measures to control reflux, such as left lateral body position, head elevation, and feeding regimen manipulation, have not been shown to reduce clinically assessed signs of GER in the preterm infant...
June 18, 2018: Pediatrics
https://www.readbyqxmd.com/read/29913281/most-patients-with-gastroesophageal-reflux-disease-who-failed-proton-pump-inhibitor-therapy-also-have-functional-esophageal-disorders
#3
Jason Abdallah, Nina George, Takahisa Yamasaki, Stephen Ganocy, Ronnie Fass
BACKGROUND & AIMS: As many as 45% of patients with gastroesophageal reflux disease (GERD) still have symptoms after receiving once-daily proton pump inhibitor (PPI) therapy. We aimed to compare reflux characteristics and patterns between responders and non-responders to once-daily PPI therapy using combined impedance-pH monitoring. METHODS: Patients who reported heartburn and/or regurgitation at least twice per week for 3 months while receiving standard-dose PPI therapy were assigned to the PPI failure group (n=16)...
June 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29910458/atypical-presentation-of-adrenocortical-insufficiency-with-anorexia-and-jaundice
#4
Xiang-Xing Li, Jie Liu, You-Lian Chen, Guang-Jian Chen, Zhen-Yu Wang, Jun-Jun Zhu, Yun-Wei Guo, Xiu-Qing Wei
BACKGROUND Adrenal insufficiency is mainly due to insufficient adrenal corticosteroid hormones secretion by the adrenal cortex, which leads to clinical manifestations such as weakness, weight loss, hyperpigmentation, hypotension, and vomiting. However, the clinical manifestations of adrenocortical insufficiency may be atypical: anorexia, ascites, impaired liver function, and alacrima have been reported. Jaundice and anorexia presenting together in the same patient as the main symptoms are rare. CASE REPORT We present a rare case of a 65-year-old woman diagnosed as having adrenocortical insufficiency with chief complaints of anorexia and jaundice...
June 18, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29909660/-effectivity-of-the-nissen-fundoplication-and-the-influencing-factors-of-the-success-results-at-the-medical-centre-of-p%C3%A3-cs-depending-on-the-indications-and-symptoms
#5
Péter Varjú, Örs Péter Horváth, András Papp, Noémi Gede, József Czimmer
INTRODUCTION: Gastroesophageal reflux disease is one of the most common gastrointestinal diseases in developed countries. Besides the conservative modalities, surgery plays an increasing role in the treatment of the disease. AIM: Our aim was to investigate and compare the surgical and 6-month follow-up data of patients to the literature (quality control), who underwent Nissen fundoplication in the Medical Centre of Pécs between 2007 and 2014, and to assess the factors (especially psychiatric comorbidity and antidepressants) influencing the success...
June 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29905881/initial-experience-of-endoscopic-radiofrequency-waves-delivery-to-the-lower-esophageal-sphincter-stretta-procedure-on-symptomatic-gastroesophageal-reflux-disease-post-sleeve-gastrectomy
#6
Nesreen Khidir, Luigi Angrisani, Jowhara Al-Qahtani, Sheraz Abayazeed, Moataz Bashah
BACKGROUND: Gastroesophageal reflux disease (GERD) occurs de novo or intensifies after sleeve gastrectomy (LSG). Endoscopic radiofrequency (Stretta) is a minimally invasive, effective tool to treat GERD. However, Stretta safety and efficacy are unknown in patients with GERD after LSG. To evaluate the safety and efficacy of Stretta treatment post-LSG GERD, quality of life, and PPI dose up to 6 months. METHODS: A retrospective review of all patients' data who underwent Stretta procedure in our center...
June 15, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29905784/blind-esophageal-brushing-offers-a-safe-and-accurate-method-to-monitor-inflammation-in-children-and-young-adults-with-eosinophilic-esophagitis
#7
Y Smadi, C Deb, J Bornstein, S Safder, K Horvath, D Mehta
Patients with eosinophilic esophagitis (EoE) require frequent evaluation of mucosal inflammation via endoscopy. Instead of endoscopy, mucosal evaluation in adults with esophageal cancer and candidiasis is achieved using a cytology brush inserted through a nasogastric tube (NGT). We conducted a prospective cross-sectional study in children and young adults scheduled for routine esophagogastroduodenoscopy (EGD) where in Phase 1, we performed esophageal brushing through the endoscope under direct visualization and in Phase 2, we inserted the brush through a Cortrak® NGT prior to endoscopy...
June 14, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29904721/surveillance-for-portal-hypertension-in-the-course-of-liver-cirrhosis
#8
REVIEW
Anna Piekarska, Ewa K Berkan, Kamila M Wójcik
Non-invasive liver fibrosis assessment techniques are under development for evaluating the severity of liver disease and portal hypertension. The paper presents practical arrangements for the diagnosis and treatment of portal hypertension in patients with chronic liver disease, established in the Baveno VI Consensus Workshop for diagnosis and treatment of portal hypertension. Currently, the diagnostic standard of liver disease severity is transient elastography, which can identify patients with clinically significant portal hypertension (liver stiffness > 20 kPa)...
June 2018: Clinical and experimental hepatology
https://www.readbyqxmd.com/read/29904178/the-phenotypic-spectrum-of-proximal-6q-deletions-based-on-a-large-cohort-derived-from-social-media-and-literature-reports
#9
Aafke Engwerda, Barbara Frentz, A Lya den Ouden, Boudien C T Flapper, Morris A Swertz, Erica H Gerkes, Mirjam Plantinga, Trijnie Dijkhuizen, Conny M A van Ravenswaaij-Arts
Proximal 6q (6q11-q15) deletions are extremely rare and little is known about their phenotypic consequences. Since parents and caregivers now use social media to seek information on rare disorders, the Chromosome 6 Project has successfully collaborated with a Facebook group to collect data on individuals worldwide. Here we describe a cohort of 20 newly identified individuals and 25 literature cases with a proximal 6q deletion. Microarray results and phenotype data were reported directly by parents via a multilingual online questionnaire...
June 8, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29902643/a-rare-case-of-hyperplastic-proximal-esophageal-polyps-with-foveolar-dysplasia
#10
Maham Hayat, Sultan Mahmood, John T Maple
A 62-year-old male with long-standing esophageal reflux underwent endoscopy at an outside institution that reported multiple polypoid lesions in upper esophagus and a small focal area of nodular mucosa at the gastroesophageal junction(GEJ). Biopsies of the proximal esophageal polyps demonstrated hyperplastic mucosa with ulceration, reactive epithelial changes, and focal intestinal metaplasia. Biopsies from the nodular GEJ mucosa were described as Barrett's esophagus with low grade dysplasia. An upper endoscopy performed at our medical center found multiple semi-pedunculated esophageal polyps between 18-24 cm from the incisors (Figure A)...
June 11, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29901103/timed%C3%A2-flat-infusion-of-5%C3%A2-fluorouracil-with-docetaxel-and-oxaliplatin-as-first%C3%A2-line-treatment-of-gastroesophageal-adenocarcinoma-a-single-institution-experience-with-the-fd-fox-regimen
#11
Alessio Cortellini, Katia Cannita, Alessandro Parisi, Olga Venditti, Paola Lanfiuti Baldi, Berardo De Berardis, Roberto Vicentini, Vincenzo Vicentini, Lucilla Verna, Giampiero Porzio, Corrado Ficorella
To date, there is no consensus regarding first‑line chemotherapy for patients with HER2‑negative, locally advanced/metastatic gastric cancer (a/m GC). In the present study we reported a retrospective case‑series of patients treated with a weekly regimen containing timed‑flat infusion of 5‑fluorouracil (TFI/5‑FU), docetaxel and oxaliplatin. From June 2007 to July 2017, 32 consecutive a/m GC patients were treated with first‑line standard (st) or modulated (mod) 'FD/FOx' regimen: Weekly 12 h (from 10...
June 6, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29899438/complications-of-antireflux-surgery
#12
REVIEW
Rena Yadlapati, Eric S Hungness, John E Pandolfino
Antireflux surgery anatomically restores the antireflux barrier and is a therapeutic option for proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease or PPI intolerance. Laparoscopic fundoplication is the standard antireflux surgery, though its popularity has declined due to concerns regarding wrap durability and adverse events. As the esophagogastric junction is an anatomically complex and dynamic area subject to mechanical stress, wraps are susceptible to disruption, herniation or slippage...
June 14, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29897443/single-center-consecutive-series-cohort-study-of-minimally-invasive-versus-open-resection-for-cancer-in-the-esophagus-or-gastroesophageal-junction
#13
F Klevebro, C M Scandavini, S Kamiya, M Nilsson, L Lundell, I Rouvelas
Minimally invasive esophagectomy (MIE) has been introduced at many centers worldwide as evidence is accumulating that it reduces the risk of postoperative morbidity and mortality and decreases the length of hospital stay compared to conventional open esophagectomy. The study is a single institution cohort study of 366 consecutive patients treated with curative intent for cancer in the esophagus or gastroesophageal junction, comparing MIE to open surgery. The outcomes studied were peroperative bleeding, operation time, lymph node yield, complications, length of stay and overall survival...
April 20, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29897337/increasing-incidence-of-paediatric-eosinophilic-esophagitis-in-the-southwestern-of-the-region-of-madrid
#14
E La Orden Izquierdo, C Gutiérrez Junquera, I Mahillo-Fernández, J Subiza Garrido-Lestache, E Román Riechmann
BACKGROUND AND OBJECTIVE: The incidence of eosinophilic esophagitis is unknown in our area. The aim of our study is to determine the incidence of diagnosis of eosinophilic esophagitis and its possible association with the most frequent absolute annual pollen counts. METHODS: A descriptive retrospective multicenter observational study was designed to calculate the incidence of eosinophilic esophagitis in children under 15 years in the southwest of the region of Madrid in 2002-2013 (provided by the Statistics Institute of Madrid)...
June 13, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29897254/the-relationship-between-primary-acquired-nasolacrimal-duct-obstruction-and-gastroesophageal-reflux
#15
Naser Owji, Mohammad Radaei, Behzad Khademi
Purpose/Aim of the study: To evaluate if there is any relationship or coincidence between Gastroesophageal reflux disease (GERD) and primary acquired nasolacrimal duct obstruction (PANDO). MATERIAL AND METHODS: We enrolled 180 patients with primary acquired nasolacrimal duct obstruction, confirmed by positive regurgitation on sac squeezing or by irrigation test. In the control group any patient with lacrimal drainage obstruction was excluded. For diagnosis of gasteroesophgal reflux we used a (Gerd Q) questionnaire by R...
June 13, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29894215/utility-of-water-siphon-maneuver-for-eliciting-gastroesophageal-reflux-during-barium-esophagography-correlation-with-histologic-findings
#16
B Dane, A Doshi, A Khan, A Megibow
OBJECTIVE: The objective of this study is to evaluate whether the water siphon maneuver improves detection of gastroesophageal (GE) reflux during barium esophagography compared with observation for spontaneous reflux only. Histopathologic analysis is the reference standard. MATERIALS AND METHODS: This retrospective study assessed 87 outpatients who underwent both barium esophagography and upper endoscopy-guided biopsy within a 30-day interval. The water siphon maneuver was routinely performed when spontaneous GE reflux was not observed during the fluoroscopic study...
June 12, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29893998/factors-associated-with-health-and-oral-health-related-quality-of-life-of-children-and-adolescents-with-cerebral-palsy
#17
Andreia Medeiros Rodrigues Cardoso, Mariana Marinho Davino de Medeiros, Lays Nóbrega Gomes, Mariana Leonel Martins, Wilton Wilney Nascimento Padilha, Alessandro Leite Cavalcanti
AIMS: To verify factors associated with impact on Health-Related Quality of Life (HRQoL) and Oral Health-Related Quality of Life (OHRQoL) of children and adolescents with cerebral palsy (CP). METHODS AND RESULTS: Sample of 149 individuals with CP aged 2 to 18 years and their caregivers, who provided information regarding HRQoL (PedsQL 4.0), OHRQoL (PedsQL 3.0 Oral Health, and socioeconomic factors. A calibrated investigator performed dental examinations, with dental caries, traumatic dental injury, periodontal, and occlusal evaluation...
June 12, 2018: Special Care in Dentistry
https://www.readbyqxmd.com/read/29892932/higher-frequency-of-upper-gastrointestinal-symptoms-in-healthy-young-japanese-females-compared-to-males-and-older-generations
#18
Kojiro Kawachi, Yasuhisa Sakata, Megumi Hara, Eri Takeshita, Hiroharu Kawakubo, Daisuke Yamaguchi, Norihiro Okamoto, Ryo Shimoda, Ryuichi Iwakiri, Nanae Tsuruoka, Motoyasu Kusano, Kazuma Fujimoto
BACKGROUND: The aim of this study was to evaluate the differences in upper gastrointestinal symptoms between generations and genders in relatively healthy Japanese subjects. METHODS: Altogether, 4086 healthy Japanese male and female (M/F) adults (M/F: 2244/1842) were analyzed. Among them, 3505 subjects (M/F: 1922/1583) were underwent a routine medical checkup at one of five hospitals in Saga, Japan from January 2013 to December 2013. The others were 581 (M/F: 322/259) healthy young volunteers at the Saga Medical School from April 2007 to March 2013...
April 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29892570/management-of-gastroesophageal-reflux-disease-in-adults-a-pharmacist-s-perspective
#19
REVIEW
Brett MacFarlane
Gastroesophageal reflux disease (GERD) is a common gastrointestinal diagnosis, a leading reason for endoscopy and cause of potentially serious complications, resulting in significant individual and system-wide health burden. Approximately one quarter of people living in western countries have experienced GERD, and the prevalence appears to be on the rise. Risk factors for GERD include hiatus hernia, obesity, high-fat diet, tobacco smoking, alcohol consumption, pregnancy, genetics, and some medications. The cardinal symptoms of GERD are troublesome heartburn and regurgitation...
2018: Integrated Pharmacy Research and Practice
https://www.readbyqxmd.com/read/29888240/before-and-after-esophageal-surgery-which-information-is-needed-from-the-functional-laboratory
#20
REVIEW
Ines Gockel, Sebastian Murad Rabe, Stefan Niebisch
Background: Indications for benign esophageal surgery and postoperative follow-up need to be highly elaborated with differentiated and structured algorithms, based on objective functional workup in the esophageal laboratory. Functional outcome is of utmost interest and has to be driven by the need for comprehensive but purposeful diagnostic methods. Methods: Preoperative diagnostic workup procedures by the functional laboratory include 24-h pH-monitoring, impedance testing, and high-resolution manometry (HRM) - in addition to upper gastrointestinal endoscopy and barium swallow/timed barium esophagogram...
April 2018: Visceral Medicine
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