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https://www.readbyqxmd.com/read/29471155/early-results-of-magnetic-sphincter-augmentation-versus-fundoplication-for-gastroesophageal-reflux-disease-systematic-review-and-meta-analysis
#1
REVIEW
Alberto Aiolfi, Emanuele Asti, Daniele Bernardi, Gianluca Bonitta, Emanuele Rausa, Stefano Siboni, Luigi Bonavina
BACKGROUND: Laparoscopic Nissen and Toupet fundoplication (LF) are currently considered gold-standard surgical treatment for Gastroesophageal Reflux Disease (GERD). Magnetic Sphincter Augmentation (MSA) is an innovative surgical procedure that has been showed to be effective to control GERD symptoms and to reduce esophageal acid exposure. The aim of this systematic review and meta-analysis was to compare early outcomes of LF and MSA. MATERIALS AND METHODS: PubMed, MEDLINE, Embase, and Cochrane databases were consulted matching the terms "Gastroesophageal reflux or heartburn", "LINX or magnetic sphincter augmentation" and "fundoplication"...
February 19, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29471114/reference-size-matching-whole-genome-amplification-and-fluorescent-labeling-as-a-method-for-chromosomal-microarray-analysis-of-clinically-actionable-copy-number-alterations-in-formalin-fixed-paraffin-embedded-tumor-tissue
#2
Shelly R Gunn, Shailin Govender, Cynthe L Sims, Aditi Khurana, Samuel Koo, Jayne Scoggin, Mathew W Moore, Philip D Cotter
Cancer genome copy number alterations (CNAs) assist clinicians in selecting targeted therapeutics. Solid tumor CNAs are most commonly evaluated in formalin-fixed, paraffin-embedded (FFPE) tissue by fluorescence in situ hybridization. Although fluorescence in situ hybridization is a sensitive and specific assay for interrogating pre-selected genomic regions, it provides no information about co-existing clinically significant copy number changes. Chromosomal microarray analysis is an alternative DNA-based method for interrogating genome-wide CNAs in solid tumors...
February 19, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29470322/pediatric-gastroesophageal-reflux-clinical-practice-guidelines-joint-recommendations-of-the-north-american-society-for-pediatric-gastroenterology-hepatology-and-nutrition-and-the-european-society-for-pediatric-gastroenterology-hepatology-and-nutrition
#3
Rachel Rosen, Yvan Vandenplas, Maartje Singendonk, Michael Cabana, Carlo DiLorenzo, Frederic Gottrand, Sandeep Gupta, Miranda Langendam, Annamaria Staiano, Nikhil Thapar, Neelesh Tipnis, Merit Tabbers
This document serves as an update of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) 2009 clinical guidelines for the diagnosis and management of gastroesophageal reflux disease (GERD) in infants and children and is intended to be applied in daily practice and as a basis for clinical trials. Eight clinical questions addressing diagnostic, therapeutic and prognostic topics were formulated...
March 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29467551/cryopreservation-for-delayed-circulating-tumor-cell-isolation-is-a-valid-strategy-for-prognostic-association-of-circulating-tumor-cells-in-gastroesophageal-cancer
#4
Daniel Brungs, David Lynch, Alison Ws Luk, Elahe Minaei, Marie Ranson, Morteza Aghmesheh, Kara L Vine, Martin Carolan, Mouhannad Jaber, Paul de Souza, Therese M Becker
AIM: To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells (PBMCs) for prognostic circulating tumor cell (CTC) detection in gastroesophageal cancer. METHODS: Using 7.5 mL blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the IsoFlux platform. Paired specimens taken during the same blood draw ( n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs...
February 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29466120/a-modified-technique-to-create-a-standardized-floppy-nissen-fundoplication-without-a-bougie
#5
Petrus S S Castelijns, Marcel C G van de Poll, Johannes F Smulders
INTRODUCTION: Nissen fundoplication is frequently applied in the surgical treatment of patients with gastroesophageal reflux disease (GERD). When the gastroesophageal junction remains too large or becomes too narrow, persistent GERD or dysphagia may occur. To assure a correct size of the gastroesophageal junction, the fundoplication can be created over a bougie. However, this increases the risk of esophageal perforation. Therefore, we have modified a previously described technique to create a standardized fundoplication without the use of a bougie...
February 21, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29466083/laparoscopic-nissen-fundoplication-an-excellent-treatment-of-gerd-related-respiratory-symptoms-in-children-results-of-a-multicentric-study
#6
Ciro Esposito, Amulya Saxena, Sabine Irtan, Holger Till, Maria Escolino
INTRODUCTION: Respiratory manifestations of gastroesophageal reflux disease (GERD), particularly chronic cough, are being recognized with increased frequency in children. This survey aimed to investigate the efficacy of laparoscopic Nissen fundoplication for treatment of GERD-related respiratory symptoms not responsive to medical therapy in neurological normal children. MATERIALS AND METHODS: We collected data of children with GERD-related respiratory complaints not responsive to medical therapy who underwent laparoscopic Nissen fundoplication in four European centers of Pediatric Surgery over a 10-year period...
February 21, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29466074/prevalence-and-survival-impact-of-pretreatment-cancer-associated-weight-loss-a-tool-for-guiding-early-palliative-care
#7
Bhavani S Gannavarapu, Steven K M Lau, Kristen Carter, Nathan A Cannon, Ang Gao, Chul Ahn, Jeffrey J Meyer, David J Sher, Aminah Jatoi, Rodney Infante, Puneeth Iyengar
PURPOSE: Cancer-associated weight loss is associated with poor prognosis in advanced malignancy; however, its pretreatment prevalence and survival impact are inadequately described in large cohorts. Such data, stratified by tumor type and stage, may facilitate the optimal and timely allocation of complementary care, leading to improvements in patient survival and quality of life. METHODS: We performed a retrospective cohort study of 3,180 consecutively treated adult patients with lung or GI (including colorectal, liver, and pancreatic) cancer...
February 21, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29462564/practice-patterns-of-referring-physicians-in-management-of-the-dysphonic-patient
#8
Andrew J Holcomb, Chelsea S Hamill, Thomas Irwin, Kevin Sykes, James D Garnett, Shannon Kraft
Objective Dysphonia is commonly encountered by primary care physicians and general otolaryngologists. We examine practice patterns of referring physicians to a tertiary voice clinic, including adherence to evidence-based guidelines. Study Design Retrospective case series with chart review. Setting Academic tertiary care hospital. Subjects and Methods In total, 821 charts of patients with voice complaints seen at a tertiary voice clinic between January 2011 and June 2016 were reviewed. Included charts (n = 755) were reviewed for type of referring provider, prior diagnoses, and treatments employed by referring physicians...
February 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29461233/peculiarities-of-quality-of-life-in-patients-with-gastroesophageal-reflux-disease
#9
G Mirijanyan
Many studies showed, that quality of life (QL ) is affected in case of gastroesophageal reflux disease (GERD). Numerous questionnaires with a wide variety of characteristics have been developed for the assessment of GERD. The current study aimed to determine the QL changes of patients with GERD. The sample consisted of 100 patients with GERD. We also formed control group, which consist of 50 practical healthy patients (without GERD). In case group we formed two subgroups- GERD with Esophagitis and GERD without Esophagitis...
January 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29460918/treatment-of-supragastric-belching-with-cognitive-behavioral-therapy-improves-quality-of-life-and-reduces-acid-gastroesophageal-reflux
#10
E Glasinovic, E Wynter, J Arguero, J Ooi, K Nakagawa, E Yazaki, P Hajek, C Clin Psych, P Woodland, D Sifrim
OBJECTIVES: Excessive supragastric belching (SGB) manifests as troublesome belching, and can be associated with reflux and significant impact on quality of life (QOL). In some GERD patients, SGB-associated reflux contributes to up to 1/3 of the total esophageal acid exposure. We hypothesized that a cognitive-behavioral intervention (CBT) might reduce SGB, improve QOL, and reduce acid gastroesophageal reflux (GOR). We aimed to assess the effectiveness of CBT in patients with pathological SGB...
February 20, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29456176/comment-on-acid-and-nonacid-gastroesophageal-reflux-after-single-anastomosis-gastric-bypass-an-objective-assessment-using-24-hour-multichannel-intraluminal-impedance-ph-metry
#11
EDITORIAL
Kenneth B Jones
No abstract text is available yet for this article.
January 31, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29455359/eosinophilic-esophagitis-an-important-comorbid-condition-of-asthma
#12
REVIEW
Sandy R Durrani, Vincent A Mukkada, Theresa W Guilbert
Eosinophilic esophagitis and asthma are frequently found as comorbid conditions in children and adults along with other manifestations of atopic diathesis. These two conditions have similar T helper 2 responses-driven pathophysiology and share common management strategies such as using systemic corticosteroids and targeted anti-cytokine biologic therapies. Review of the literature finds that asthma is often a comorbid condition in eosinophilic esophagitis in both children and adults; however, the EoE-asthma relationship remains poorly characterized mechanistically and clinically...
February 18, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29454796/endoscopic-myotomy-for-foregut-motility-disorders
#13
Mouen A Khashab, Petros C Benias, Lee L Swanstrom
Peroral endoscopic myotomy (POEM) is an advanced endoscopic procedure classically performed for the treatment of achalasia. The procedure is based on principles of submucosal endoscopy and is comprised of a mucosal incision, submucosal tunneling, myotomy and mucosal closure. Multiple published studies that collectively include more than 6000 patients reported clinical success in more than 80-90% of patients. Recent literature also suggested durability of response over a medium-term follow-up. POEM is associated with a low rate of adverse events when performed by experienced operators...
February 15, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29453868/coexistent-solid-malignancies-in-pemphigus-a-population-based-study
#14
Khalaf Kridin, Shira Zelber-Sagi, Doron Comaneshter, Arnon D Cohen
Importance: The association of pemphigus vulgaris and pemphigus foliaceus with comorbid malignancies is yet to be firmly established. Objective: To estimate the association between pemphigus and a wide range of nonhematologic malignancies using one of the largest cohorts of patients with pemphigus to date. Design, Setting, and Participants: For this cross-sectional study, we used the computerized database of Clalit Health Services, the largest public health care provider organization in Israel insuring 4...
February 16, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29449669/predictive-biomarkers-of-gastroesophageal-reflux-disease-and-barrett-s-esophagus-in-world-trade-center-exposed-firefighters-a-15-year-longitudinal-study
#15
Syed H Haider, Sophia Kwon, Rachel Lam, Audrey K Lee, Erin J Caraher, George Crowley, Liqun Zhang, Theresa M Schwartz, Rachel Zeig-Owens, Mengling Liu, David J Prezant, Anna Nolan
Gastroesophageal reflux disease (GERD) and Barrett's Esophagus (BE), which are prevalent in the World Trade Center (WTC) exposed and general populations, negatively impact quality of life and cost of healthcare. GERD, a risk factor of BE, is linked to obstructive airways disease (OAD). We aim to identify serum biomarkers of GERD/BE, and assess the respiratory and clinical phenotype of a longitudinal cohort of never-smoking, male, WTC-exposed rescue workers presenting with pulmonary symptoms. Biomarkers collected soon after WTC-exposure were evaluated in optimized predictive models of GERD/BE...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449271/targeted-therapies-for-targeted-populations-anti-egfr-treatment-for-egfr-amplified-gastroesophageal-adenocarcinoma
#16
Steven B Maron, Lindsay Alpert, Heewon A Kwak, Samantha Lomnicki, Leah Chase, David Xu, Emily O'Day, Rebecca J Nagy, Richard B Lanman, Fabiola Cecchi, Todd Hembrough, Alexa Schrock, John Hart, Shu-Yuan Xiao, Namrata Setia, Daniel V T Catenacci
Previous anti-EGFR trials in unselected gastroesophageal adenocarcinoma (GEA) patients were resoundingly negative. We identified EGFR amplification in 5% (19/363) of patients at the University of Chicago, including 6% (8/140) who were prospectively screened with intention-to-treat using anti-EGFR therapy. Seven pts received >1 dose of treatment: three first line FOLFOX plus ABT-806, one second line FOLFIRI plus cetuximab, and three third/fourth line cetuximab alone. Treatment achieved objective response in 58% (4/7) and disease control in 100% (7/7) with a median progression-free survival of 10 months...
February 15, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29447372/small-fiber-polyneuropathy-is-prevalent-in-patients-experiencing-complex-chronic-pelvic-pain
#17
Annie Chen, Elise De, Charles Argoff
Objective: To demonstrate the prevalence of small fiber polyneuropathy (SFPN) in patients with refractory chronic pelvic pain (CPP). Design: Retrospective study of prospective database. Subjects: Participants were complex CPP patients recruited from subspecity referral clinics defined as those who were refractory to initial treatment and/or exhibited comorbid pain syndromes at initial presentation. Methods: Comprehensive treatment history for CPP was obtained, and participants referred as above; 3-mm punch biopsies were obtained of the lower extremity and sent to diagnostic reference labs to evaluate for SFPN...
February 13, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29445216/evaluation-of-her2-specific-peptide-ligand-for-its-employment-as-radiolabeled-imaging-probe
#18
Hadis Honarvar, Enrica Calce, Nunzianna Doti, Emma Langella, Anna Orlova, Jos Buijs, Valentina D'Amato, Roberto Bianco, Michele Saviano, Vladimir Tolmachev, Stefania De Luca
HER2 transmembrane receptor is an important target in immunotherapy treatment of breast and gastroesophageal cancer. Molecular imaging of HER2 expression may provide essential prognostic and predictive information concerning disseminated cancer and aid in selection of an optimal therapy. Radiolabeled low molecular weight peptide ligands are particularly attractive as probes for molecular imaging, since they reach and bind to the target and clear from non-target organs and blood stream faster than bulky antibodies...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444329/gastroesophageal-reflux-symptoms-are-not-sufficient-to-guide-esophageal-function-testing-in-lung-transplant-candidates
#19
S Posner, J Zheng, R K Wood, R A Shimpi, M G Hartwig, S-C Chow, D A Leiman
Gastroesophageal reflux disease and esophageal dysmotility are prevalent in patients with advanced lung disease and are associated with graft dysfunction following lung transplantation. As a result, many transplant centers perform esophageal function testing as part of the wait-listing process but guidelines for testing in this population are lacking. The aim of this study is to describe whether symptoms of gastroesophageal reflux correlate with abnormal results on pH-metry and high-resolution manometry and can be used to identify those who require testing...
February 9, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29444254/high-resolution-esophageal-manometry-in-a-mexican-population-diagnostic-outcome
#20
G Vazquez-Elizondo, L E Hernández-González, S R Achem
High-resolution esophageal manometry (HREM) has become the method of choice for evaluation of esophageal motility disorders. There is a paucity of data with this technique from Hispanic countries. This study aims to characterize the diagnostic outcome of HREM in a large cohort of consecutive patients in Mexico.This study was conducted in Monterrey, Mexico from March 1, 2013 to March 31, 2015. Our diverse study population included patients from a major academic institution and the community. HREM was done applying the Chicago Classification 3...
February 9, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
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