keyword
https://read.qxmd.com/read/38485552/esophagogastric-cancer-the-current-role-of-radiation-therapy
#21
REVIEW
Leila T Tchelebi, Karyn A Goodman
Radiation therapy is an effective treatment modality in the management of patients with esophageal cancer regardless of tumor location (proximal, middle, or distal esophagus) or histology (squamous cell vs adenocarcinoma). The addition of neoadjuvant CRT to surgery in patients who are surgical candidates has consistently shown a benefit in terms of locoregional recurrence, pathologic downstaging, and overall survival. For patients who are not surgical candidates, CRT has a role as definitive treatment.
March 13, 2024: Hematology/oncology Clinics of North America
https://read.qxmd.com/read/38485551/targeted-agents-in-esophagogastric-cancer-beyond-human-epidermal-growth-factor-receptor-2
#22
REVIEW
Eric Mehlhaff, Devon Miller, Johnathan E Ebben, Oleksii Dobrzhanskyi, Nataliya V Uboha
Gastroesophageal cancers are highly diverse tumors in terms of their anatomic and molecular characteristics, making drug development challenging. Recent advancements in understanding the molecular profiles of these cancers have led to the identification of several new biomarkers. Ongoing clinical trials are investigating new targeted agents with promising results. CLDN18.2 has emerged as a biomarker with established activity of associated targeted therapies. Other targeted agents, such as bemarituzumab and DKN-01, are under active investigation...
March 13, 2024: Hematology/oncology Clinics of North America
https://read.qxmd.com/read/38482214/postoperative-superior-anastomotic-leakage-classification-and-treatment-strategy-for-postoperative-esophagogastric-junction-cancer
#23
JOURNAL ARTICLE
Junli Zhang, Changzheng Li, Pengfei Ma, Yanghui Cao, Janusz Włodarczyk, Mohsen Ibrahim, Chenyu Liu, Sen Li, Xijie Zhang, Guangsen Han, Yuzhou Zhao
BACKGROUND: At present, anastomotic fistula cannot be avoided after adenocarcinoma of the esophagogastric junction (AEG). Once the anastomotic leakage occurs, the posterior mediastinum and the left thoracic cavity are often seriously infected, which further impairs respiratory and circulatory function, heightening the danger of the disease course. The aim of this study was to identify the characteristics of superior anastomotic leakage after surgery for AEG and recommend corresponding treatment strategies to improve the diagnosis and treatment of superior anastomotic leakage after surgery for AEG...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38477514/efficacy-and-safety-of-atezolizumab-plus-bevacizumab-in-patients-with-portal-hypertension-for-unresectable-hepatocellular-carcinoma
#24
JOURNAL ARTICLE
Takahiro Kinami, Shinsuke Uchikawa, Tomokazu Kawaoka, Shintaro Yamasaki, Masanari Kosaka, Yusuke Johira, Shigeki Yano, Kei Amioka, Kensuke Naruto, Kenji Yamaoka, Yasutoshi Fujii, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Wataru Okamoto, Masami Yamauchi, Daiki Miki, Masataka Tsuge, Shiro Oka
AIM: Atezolizumab plus bevacizumab combination therapy (Atezo + Beva) is used as the first-line therapy for unresectable hepatocellular carcinoma (u-HCC). Serious adverse events (AEs), including rupture of esophagogastric varices, have been seen during treatment. Therefore, the relationships of efficacy, safety, and portal hypertension (PH) were analyzed. METHODS: A total of 146 patients with u-HCC and Child-Pugh Scores of 5-7 received Atezo + Beva. Prophylactic treatment for varices was performed for patients with the risk of rupture of varices before the start of Atezo + Beva...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38467986/preoperative-docetaxel-cisplatin-and-5-fluorouracil-for-resectable-locally-advanced-esophageal-and-esophagogastric-junctional-adenocarcinoma
#25
JOURNAL ARTICLE
Toshiharu Hirose, Shun Yamamoto, Yoshitaka Honma, Kazuki Yokoyama, Hidekazu Hirano, Natsuko Okita, Hirokazu Shoji, Satoru Iwasa, Atsuo Takashima, Koshiro Ishiyama, Junya Oguma, Hiroyuki Daiko, Shin Maeda, Ken Kato
BACKGROUND: Chemotherapy consisting of 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel is the standard perioperative treatment for resectable esophageal adenocarcinoma and esophagogastric junctional adenocarcinoma (EGJ-AC) in Western countries. Meanwhile, preoperative chemotherapy consisting of docetaxel, cisplatin, and 5-fluorouracil (DCF) has been developed for esophageal squamous cell carcinoma in Japan. However, there are few reports on the safety and efficacy of preoperative DCF for resectable EGJ-AC in the Japanese population...
March 12, 2024: Esophagus: Official Journal of the Japan Esophageal Society
https://read.qxmd.com/read/38466235/lymph-node-metastases-in-middle-and-upper-mediastinum-of-siewert-type-ii-adenocarcinoma-a-real-world-retrospective-study
#26
JOURNAL ARTICLE
Peng Luo, Xiankai Chen, Yafan Yang, Ruixiang Zhang, Xiaozheng Kang, Jianjun Qin, Xiuzhu Qi, Yin Li
OBJECTIVE: To explore whether the upper and/or middle mediastinal nodes (UMMN) should be dissected in Siewert type II adenocarcinoma (AC) according to the incidence of lymph node metastasis. Additionally, to investigate the association between the length of esophageal involvement (LEI) and the UMMN metastases. METHODS: A cohort with Siewert type II AC who were operated on by a surgical team that routinely treated esophagogastric junction (EGJ) tumors with esophagectomy and extended lymphadenectomy were assessed retrospectively...
February 2024: Cancer Medicine
https://read.qxmd.com/read/38463371/efficacy-of-transjugular-intrahepatic-portosystemic-shunts-in-treating-cirrhotic-esophageal-gastric-variceal-bleeding
#27
JOURNAL ARTICLE
Xiao-Gang Hu, Jian-Ji Dai, Jun Lu, Gang Li, Jia-Min Wang, Yi Deng, Rui Feng, Kai-Ping Lu
BACKGROUND: Esophageal-gastric variceal bleeding (EGVB) represents a severe complication among patients with cirrhosis and often culminates in fatal outcomes. Interventional therapy, a rapidly developing treatment modality over the past few years, has found widespread application in clinical practice due to its minimally invasive characteristics. However, whether transjugular intrahepatic portosystemic shunt (TIPS) treatment has an impact on patient prognosis remains controversial. AIM: To probing the efficacy of TIPS for treating cirrhotic EGVB and its influence on the prognosis of patients afflicted by this disease...
February 27, 2024: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38458620/peroral-endoscopic-myotomy-and-its-use-in-non-achalasia-disorders
#28
JOURNAL ARTICLE
Arvind Rengarajan, A Aziz Aadam
The aim of this review is to provide an overview of per-oral endoscopic myotomy (POEM) and its utilization in non-achalasia disorders of the esophagus. POEM, a relatively novel endoscopic technique, involves submucosal tunneling to access esophageal muscle layers, enabling selective myotomy and mitigating the consequences of motor disorders of the esophagus. POEM is an effective treatment modality for diffuse esophageal spasm providing resolution of chest pain and dysphagia in a majority of patients who have refractory symptoms despite medical therapy...
March 8, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38458239/multiple-snares-assisted-endoscopic-full-thickness-resection-of-a-giant-submucosal-tumor-at-the-esophagogastric-junction
#29
JOURNAL ARTICLE
Jiyu Zhang, Miao Shi, Dan Liu, Lixia Zhao, Bingrong Liu
No abstract text is available yet for this article.
December 2024: Endoscopy
https://read.qxmd.com/read/38455483/adequate-gross-resection-margin-length-ensuring-pathologically-complete-resection-in-gastrectomy-for-gastric-cancer-a-systematic-review-and-meta-analysis
#30
REVIEW
Masaru Hayami, Manabu Ohashi, Nozomi Kurihara, Souya Nunobe
AIM: A positive resection margin (RM) is associated with poor survival after gastrectomy for gastric cancer (GC). However, the adequate RM length to avoid a positive RM remains controversial. We performed a systematic review to examine the RM length required to avoid a positive RM in gastrectomy for GC. METHODS: This systematic review involved all relevant articles identified in PubMed, the Cochrane Library, Web of Science, and ClinicalTrials.gov until August 2023...
March 2024: Annals of Gastroenterological Surgery
https://read.qxmd.com/read/38453749/assessing-risk-of-recurrent-small-bowel-obstruction-after-non-operative-management-in-patients-with-history-of-intra-abdominal-surgery-a-population-based-comprehensive-analysis-in-taiwan
#31
JOURNAL ARTICLE
Shang-Wei Lin, Chung-Yen Chen, Pin-Chun Chen, Che-Lun Feng, Hung-Yu Lin, Jian-Han Chen
BACKGROUND: Despite a significant 30% ten-year readmission rate for SBO patients, investigations into recurrent risk factors after non-operative management are scarce. The study aims to generate a risk factor scoring system, the 'Small Bowel Obstruction Recurrence Score' (SBORS), predicting 6-month recurrence of small bowel obstruction (SBO) after successful non-surgical management in patients who have history of intra-abdominal surgery. METHODS: We analyzed data from patients aged ≥ 18 with a history of intra-abdominal surgery and diagnosed with SBO (ICD-9 code: 560, 568) and were successful treated non-surgically between 2004 and 2008...
March 7, 2024: Surgical Endoscopy
https://read.qxmd.com/read/38441680/placing-vacuum-sponges-in-esophageal-anastomotic-leaks-how-we-do-it
#32
JOURNAL ARTICLE
Florian Hentschel, Götz Mollenhauer, Björn Siemssen, Christoph Paasch, René Mantke, Stefan Lüth
PURPOSE: Endoluminal vacuum sponge therapy has dramatically improved the treatment of anastomotic leaks in esophageal surgery. However, the blind insertion of vacuum sponge kits like Eso-Sponge® via an overtube and a pusher can be technically difficult. METHODS: We therefore insert our sponges under direct visual control by a nonstandard "piggyback" technique that was initially developed for the self-made sponge systems preceding these commercially available kits...
March 5, 2024: Langenbeck's Archives of Surgery
https://read.qxmd.com/read/38438672/prognosis-of-lspd-versus-tips-for-the-treatment-of-esophagogastric-variceal-bleeding-in-cirrhosis
#33
JOURNAL ARTICLE
Biao Chen, Jingxuan Wang, Weiyong Sheng, Bingqing Ma, Peng Xu, Xing Cheng, Weiyi Cheng, Chengjun Cai, Guoliang Wang, Wenming Pan, Chidan Wan, Chuansheng Zheng, Ping Cheng, Jinxiang Zhang
BACKGROUND: This study aimed to compare postoperative complications in patients with esophagogastric variceal bleeding (EVB) who underwent laparoscopic splenectomy combined with pericardial devascularization (LSPD) versus transjugular intrahepatic portosystemic shunt (TIPS) procedures. METHODS: A retrospective collection of medical records was conducted from January 2014 to May 2020 at Union Hospital, Tongji Medical College, Huazhong University of Science and Technology...
March 4, 2024: Surgical Endoscopy
https://read.qxmd.com/read/38428860/assessment-of-risk-factors-of-lymph-node-metastasis-and-prognosis-of-siewert-ii-iii-adenocarcinoma-of-esophagogastric-junction-a-retrospective-study
#34
JOURNAL ARTICLE
Yidong Huang, Zhi Zheng, Rui Xu, Haiqiao Zhang, Jie Yin, Xiaoye Liu, Jun Zhang, Guangyong Chen, Zhongtao Zhang
Adenocarcinoma of the esophagogastric junction (AEG) has a high incidence, and the extent of lymph node dissection (LND) and its impact on prognosis remain controversial. This study aimed to explore the risk factors for lymph node metastasis (LNM) and prognosis in Siewert II/III AEG patients. A retrospective review of 239 Siewert II/III AEG patients surgically treated at Beijing Friendship Hospital from July 2013 to December 2022 was conducted. Preoperative staging was conducted via endoscopy, ultrasound gastroscopy, CT, and biopsy...
March 1, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38425390/prognostic-nutritional-index-in-predicting-survival-of-patients-with-gastric-or-gastroesophageal-junction-adenocarcinoma-a-systematic-review
#35
JOURNAL ARTICLE
Stylianos Fiflis, Grigorios Christodoulidis, Menelaos Papakonstantinou, Alexandros Giakoustidis, Stergos Koukias, Paraskevi Roussos, Marina Nektaria Kouliou, Konstantinos Eleftherios Koumarelas, Dimitrios Giakoustidis
BACKGROUND: Gastric cancer is the third most common cause of cancer related death worldwide. Surgery with or without chemotherapy is the most common approach with curative intent; however, the prognosis is poor as mortality rates remain high. Several indexes have been proposed in the past few years in order to estimate the survival of patients undergoing gastrectomy. The preoperative nutritional status of gastric cancer patients has recently gained attention as a factor that could affect the postoperative course and various indexes have been developed...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38420853/neoadjuvant-therapy-with-immune-checkpoint-inhibitors-in-combination-with-chemotherapy-vs-chemotherapy-alone-in-her2-locally-advanced-gastric-cancer-a-propensity-score-matched-cohort-study
#36
JOURNAL ARTICLE
Gehan Xu, Tianjiao Liu, Jingyi Shen, Quanlin Guan
BACKGROUND: This study aims to compare the efficacy between neoadjuvant immune checkpoint inhibitors (ICIs) plus chemotherapy vs. chemotherapy, and neoadjuvant triplet vs. doublet chemotherapeutic regimens in locally advanced gastric/esophagogastric junction cancer (LAGC). METHODS: We included LAGC patients from 47 hospitals in China's National Cancer Information Database (NCID) from January 2019 to December 2022. Using propensity score matching (PSM), we retrospectively analyzed the efficacy between neoadjuvant ICIs plus chemotherapy vs...
February 29, 2024: Chinese Medical Journal
https://read.qxmd.com/read/38420534/association-of-conduit-dimensions-with-perioperative-outcomes-and-long-term-quality-of-life-after-esophagectomy-for-malignancy
#37
JOURNAL ARTICLE
SangMin Kim, Sun Yeop Lee, Nuno Vaz, Rachel Leo, Rafael R Barcelos, Rena Mototani, Antonio Lozano, Evert Andrew Sugarbaker, Sarah S Oh, Francine Jacobson, Jon O Wee, Michael T Jaklitsch, M Blair Marshall
OBJECTIVE: The impact of conduit dimensions and location of esophagogastric anastomosis on long-term quality of life after esophagectomy remains unexplored. We investigated the association of these parameters with surgical outcomes and patient-reported quality of life at least 18 months after esophagectomy. METHODS: We identified all patients who underwent esophagectomy for cancer from 2018 to 2020 in our institution. We reviewed each patient's initial postoperative computed tomography scan measuring the gastric conduit's greatest width (centimeters), linear staple line length (centimeters), and relative location of esophagogastric anastomosis (vertebra)...
February 2024: JTCVS open
https://read.qxmd.com/read/38420481/clinical-significance-of-systemic-inflammation-response-index-and-platelet-lymphocyte-ratio-in-patients-with-adenocarcinoma-of-the-esophagogastric-junction-and-upper-gastric-cancer
#38
JOURNAL ARTICLE
Tianyi Fang, Xin Yin, Yufei Wang, Lei Zhang, Shuo Yang, Xinju Jiang, Yingwei Xue
BACKGROUND: Tumor immunity plays an important role in assessing the tumor progression. The purpose of this study was to investigate the prognostic value of combined systemic inflammation response index (SIRI) and platelet-lymphocyte ratio (PLR) of gastroesophageal junction cancer (AEG) and upper gastric cancer (UGC) patients. METHODS: In this retrospective study, patients from 2003 to 2014 were divided into training and validation sets. The prognostic accuracy of each variable was compared using time-independent ROC analysis...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38420259/why-so-many-patients-with-dysphagia-have-normal-esophageal-function-testing
#39
JOURNAL ARTICLE
Ravinder K Mittal, Ali Zifan
Esophageal peristalsis involves a sequential process of initial inhibition (relaxation) and excitation (contraction), both occurring from the cranial to caudal direction. The bolus induces luminal distension during initial inhibition (receptive relaxation) that facilitates smooth propulsion by contraction travelling behind the bolus. Luminal distension during peristalsis in normal subjects exhibits unique characteristics that are influenced by bolus volume, bolus viscosity, and posture, suggesting a potential interaction between distension and contraction...
2024: Gastro Hep Adv
https://read.qxmd.com/read/38418167/-the-association-between-portal-vein-thrombosis-and-rebleeding-after-non-urgent-endoscopic-treatment-of-esophagogastric-varices
#40
JOURNAL ARTICLE
J X Li, Z J Li, H M Zhang, S S Xu, R Z Quan, H Zhang, M M Lu, X Y Wang, S Ma, J Mi, H Ding, X L Li
Objective: To investigate the association between portal vein thrombosis and rebleeding after non-urgent endoscopic treatment of esophagogastric varices. Methods: The cirrhotic patients with esophagogastric varices diagnosed in the People's Hospital of Zhengzhou University from January 2017 to March 2023 were retrospectively collected. The patients were divided into thrombotic group and non-thrombotic group according to the presence or absence of portal vein thrombosis. The failure rate of endoscopic treatment and rebleeding rate in different periods were compared between the two groups...
March 5, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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