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https://www.readbyqxmd.com/read/29774149/the-rome-iv-versus-rome-iii-criteria-for-heartburn-diagnosis-a-comparative-study
#1
Mengyu Zhang, Minhu Chen, Sui Peng, Yinglian Xiao
Background: The phenotypes of heartburn patients are heterogeneous. Objective: The objective of this study was to investigate the proportion of heartburn phenotypes in a Chinese population and to compare the Rome IV and III criteria for heartburn diagnosis. Methods: A retrospective study was performed among heartburn patients referred for upper endoscopy and esophageal function tests in a tertiary hospital. Their symptoms fulfilled Rome IV and III criteria...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29763597/a-hem-o-lok-induced-tracheoesophageal-fistula-cured-by-temporary-airway-stenting-modified-with-three-dimensional-printing
#2
Yichao Han, Su Yang, Wei Huang, Zhongmin Wang, Hecheng Li
We present the case of a fistula between the trachea and the esophagogastric anastomosis in a 58-year-old male after esophagectomy. A Hem-o-Lok clip used at the time to ligate the azygos vein was discovered by esophagoscopy and bronchoscopy to be eroding into the both structures. A covered self-expandable Y-shaped metallic tracheobronchial stent was customized with a 3D printed airway model and inserted in place, with endoscopic injection of fibrin glue to the anastomotic site. 64 days after implantation, the stent was withdrawn with complete healing of the fistula...
May 12, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29761528/nonerosive-reflux-disease-clinical-concepts
#3
REVIEW
C Prakash Gyawali, Dan E Azagury, Walter W Chan, Servarayan M Chandramohan, John O Clarke, Nicola de Bortoli, Edgar Figueredo, Mark Fox, Daniela Jodorkovsky, Adriana Lazarescu, Peter Malfertheiner, Jan Martinek, Kenric M Murayama, Roberto Penagini, Edoardo Savarino, Katerina P Shetler, Ellen Stein, Roger P Tatum, Justin Wu
Esophageal symptoms can arise from gastroesophageal reflux disease (GERD) as well as other mucosal and motor processes, structural disease, and functional esophageal syndromes. GERD is the most common esophageal disorder, but diagnosis may not be straightforward when symptoms persist despite empiric acid suppressive therapy and when mucosal erosions are not seen on endoscopy (as for nonerosive reflux disease, NERD). Esophageal physiological tests (ambulatory pH or pH-impedance monitoring and manometry) can be of value in defining abnormal reflux burden and reflux-symptom association...
May 15, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29743108/-18-fdg-pet-ct-identifies-histopathological-non-responders-after-neoadjuvant-chemotherapy-in-locally-advanced-gastric-and-cardia-cancer-cohort-study
#4
Paul M Schneider, Dilmurodjon Eshmuminov, Tamara Rordorf, Diana Vetter, Patrick Veit-Haibach, Achim Weber, Peter Bauerfeind, Panagiotis Samaras, Kuno Lehmann
BACKGROUND: Pathologic response to neoadjuvant chemotherapy (neoCTX) is a prognostic factor in many cancer types, and early prediction would help to modify treatment. In patients with gastric and esophagogastric junction (AEG) cancer, the accuracy of FDG PET-CT to predict early pathologic response after neoadjuvant chemotherapy (neoCTX) is currently not known. METHODS: From a consecutive cohort of 72 patients, 44 patients with resectable, locally-advanced gastric cancer or AEG Siewert type II and III received neoCTX after primary staging with endoscopic ultrasound, PET-CT and laparoscopy...
May 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29740725/a-case-of-mixed-adenoneuroendocrine-carcinoma-manec-arising-in-barrett-s-esophagus-literature-and-review
#5
Tetsuro Kawazoe, Hiroshi Saeki, Keitaro Edahiro, Shotaro Korehisa, Daisuke Taniguchi, Kensuke Kudou, Ryota Nakanishi, Nobuhide Kubo, Koji Ando, Yuichiro Nakashima, Eiji Oki, Minako Fujiwara, Yoshinao Oda, Yoshihiko Maehara
BACKGROUND: Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a neoplasm composed of both exocrine and endocrine carcinomas, each comprising at least 30% of the tumor. MANEC can occur in various organs of the gastrointestinal tract, including the esophagus, stomach, and colon. We herein provide the first case report of surgically resected MANEC arising in Barrett's esophagus (BE). CASE PRESENTATION: A 70-year-old man presenting with abdominal pain was referred to our hospital...
May 8, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29733013/neoadjuvant-radiochemotherapy-for-patients-with-locally-advanced-esophagogastric-junction-adenocarcinoma
#6
Cristian Daniel Marica, Rodica Birlă, Raluca Marica, Eugenia Panaitescu, Silviu Constantinoiu
SCOPE: neoadjuvant RCT influence on early and long term postoperative outcomes in patients with locally advanced esophagogastric junction adenocarcinomas. MATERIALS AND METHOD: Sixty two patients with locally advanced esophagogastric junction adenocarcinomas were treated at the Center of Excellence in Esophageal Surgery at St. Mary Hospital between 2010-2017. According to the Siewert classification, the group comprised of type I - 11 patients, type II - 18 patients and type III - 33 patients...
March 2018: Chirurgia
https://www.readbyqxmd.com/read/29725401/rapid-progression-of-a-granulocyte-colony-stimulating-factor-producing-liver-tumor-metastasized-from-esophagogastric-junction-cancer-a-case-report-and-literature-review
#7
Sojun Hoshimoto, Nobuo Hoshi, Iwao Ozawa, Moriaki Tomikawa, Hirofumi Shirakawa, Takeshi Fujita, Saho Wakamatsu, Sayuri Hoshi, Kaoru Hirabayashi, Shoichi Hishinuma, Yoshiro Ogata
The current study presents the case of a 72-year-old woman with a rapidly enlarged liver metastasis from esophagogastric junction (EGJ) cancer, accompanied by progressive leukocytosis (47,680/µl) and elevated serum granulocyte colony-stimulating factor (G-CSF; 779 pg/ml). The patient underwent right hemihepatectomy 26 months after a total gastrectomy. On the seventh post-operative day the patient's leukocyte count and serum G-CSF level decreased to 4,280/µl and ≤19.5 pg/ml, respectively. Histologically, the lesion was a well to moderately differentiated adenocarcinoma similar to the primary lesion...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29724301/-clinical-value-of-multi-slice-spiral-enhanced-ct-in-diagnosing-mild-digestive-tract-hemorrhage
#8
Xiao Ling Wen, Li Wang, Xiao Qin Song, Zhi Zhang, Xiao Fang Zhu, Shao Ping Wu
Objective To investigate the clinical value of multi-slice spiral CT(MSCT) in the diagnosis of mild digestive tract hemorrhage. Methods Thirty-five patients with mild gastrointestinal hemorrhage were examined by enhanced MSCT.CT signs were observed and compared with pathologic examination findings.Results Diseases in these 35 patients included gastric and duodenal ulcer and inflammation(n=4,11.4%),esophagogastric variceal rupture(n=7,20.0%),gastric carcinoma(n=3,8.6%),gastric stromal tumor(n=3,8.6%),gastric polyp(n=1,2...
April 28, 2018: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29713739/barium-upper-gi-series-in-adults-a-surgeon-s-perspective
#9
Daniel T Dempsey
Barium upper GI series performed by an interested and competent radiologist is still a very useful study to evaluate a variety of esophagogastric disorders. It usually provides information complementary to upper endoscopy and other foregut studies. Barium upper GI series is an important part of the diagnostic workup for gastroesophageal reflux disease, hiatal hernia, and esophageal motility disorders including achalasia. It is also an important part of the follow-up after operation for these common problems and after other operations such as resection or bariatric surgery...
April 30, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29712576/endoscopically-assisted-transcervical-esophagogastric-tube-placement-for-nonoperative-intestinal-obstruction-an-alternative-to-peg-placement
#10
Asif Talukder, Karen Draper, Carsten Schroeder
No abstract text is available yet for this article.
April 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29702296/advances-in-management-of-esophageal-motility-disorders
#11
REVIEW
Peter J Kahrilas, Albert J Bredenoord, Dustin A Carlson, John E Pandolfino
The widespread adoption of high-resolution manometry (HRM) has led to a restructuring in the classification of esophageal motility disorder classification summarized in the Chicago Classification, currently in version 3.0. It has become apparent that the cardinal feature of achalasia, impaired lower esophageal sphincter relaxation, can occur in several disease phenotypes: without peristalsis, with premature (spastic) distal esophageal contractions, with panesophageal pressurization, or even with preserved peristalsis...
April 24, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29698944/mucosally-expressed-cytokines-are-associated-with-the-esophageal-motility-function
#12
Keita Fukaura, Eikichi Ihara, Haruei Ogino, Yoichiro Iboshi, Kazumasa Muta, Bai Xiaopeng, Shohei Hamada, Yoshitaka Hata, Tsutomu Iwasa, Akira Aso, Kazuhiko Nakamura, Yoshihiro Ogawa
BACKGROUND AND AIM: Although basic research has shown that certain cytokines affect gastrointestinal motility, the clinical evidence is lacking. The objective of this study was to explore the association between mucosally expressed cytokines and the esophageal motility function in humans. METHODS: We enrolled a total of 57 patients with suspected esophageal motility disorders (EMDs) who underwent high-resolution manometry. RESULTS: The diagnoses of the patients were as follows: normal esophageal motility (n = 25), ineffective esophageal motility (n = 5), esophagogastric junction outflow obstruction (EGJOO; n = 10), distal esophageal spasm (n = 5), achalasia (n = 10), absent contractility (n = 1), and jackhammer esophagus (n = 1)...
April 26, 2018: Digestion
https://www.readbyqxmd.com/read/29696360/randomized-phase-2-study-of-gemcitabine-and-cisplatin-with-or-without-vitamin-supplementation-in-patients-with-advanced-esophagogastric-cancer
#13
A A van Zweeden, C J van Groeningen, R J Honeywell, E Giovannetti, R Ruijter, C H Smorenburg, G Giaccone, H M W Verheul, G J Peters, Hans J van der Vliet
PURPOSE: Preclinical research and prior clinical observations demonstrated reduced toxicity and suggested enhanced efficacy of cisplatin due to folic acid and vitamin B12 suppletion. In this randomized phase 2 trial, we evaluated the addition of folic acid and vitamin B12 to first-line palliative cisplatin and gemcitabine in patients with advanced esophagogastric cancer (AEGC). METHODS: Patients with AEGC were randomized to gemcitabine 1250 mg/m2 (i.v. days 1, 8) and cisplatin 80 mg/m2 (i...
April 25, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29685755/surgery-for-metastases-for-esophageal-gastric-cancer-in-the-real-world-data-from-the-agamenon-national-registry
#14
Alberto Carmona-Bayonas, Paula Jiménez-Fonseca, Isabel Echavarria, Manuel Sánchez Cánovas, Gema Aguado, Javier Gallego, Ana Custodio, Raquel Hernández, Antonio Viudez, Juana María Cano, Eva Martínez de Castro, Ismael Macías, Alfonso Martín Carnicero, Marcelo Garrido, Monserrat Mangas, Felipe Álvarez Manceñido, Laura Visa, Aitor Azkarate, Avinash Ramchandani, Ana Fernández Montes, Federico Longo, Ana Sánchez, Paola Pimentel, María Luisa Limón, David Arias, Diego Cacho Lavin, Rodrigo Sánchez Bayona, Paula Cerdá, Pilar García Alfonso
INTRODUCTION: The effect of surgery for metastases in patients with esophagogastric cancer is unknown, given the lack of randomized clinical trials; likewise, the criteria for selecting eligible patients remain to be determined. METHODS: This registry evaluates the results of patients with advanced adenocarcinoma of the stomach, distal esophagus, or gastro-esophageal junction from 32 centers. To assess selection criteria and prognostic factors, a state arrival extended Markov proportional hazards (PH) model was used...
March 31, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29682624/non-exposed-endoscopic-wall-inversion-surgery-for-gastrointestinal-stromal-tumor
#15
Takashi Mitsui, Hiroharu Yamashita, Susumu Aikou, Keiko Niimi, Mitsuhiro Fujishiro, Yasuyuki Seto
Laparoscopic and endoscopic cooperative surgery (LECS) is an accepted method of laparoscopic wedge resection, which is minimally invasive, for gastrointestinal stromal tumors (GISTs). We established a type of LECS achieving a full-thickness resection, non-exposed endoscopic wall-inversion surgery (NEWS), in an effort to prevent exposure of the peritoneal cavity to gastric intraluminal contents. We employed this surgical technique in 28 gastric GIST patients. We failed to complete NEWS in the initial two patients and in one patient with a large tumor (40 mm × 35 mm), but otherwise carried out the procedure successfully...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29666800/strategies-of-nodal-staging-of-the-tnm-system-for-esophageal-cancer
#16
REVIEW
Wen-Ping Wang, Song-Lin He, Yu-Shang Yang, Long-Qi Chen
The 8th edition of UICC/AJCC TNM staging for esophageal cancer will start in use since 2018. The nodal staging in this version of TNM system remains unchanged from the 7th edition that based on the number of lymph nodes (LN) involved, except the limited revision of the regional LN map. In this review, N staging revision was evaluated from its initially simple definition of negative (N0) and positive (N1) LN(s) to the current positive node number based proposal. Meanwhile the disadvantages of current N staging were discussed...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29662932/combined-extensive-esophageal-squamous-papillomas-and-florid-cardiac-gland-hyperplasia-in-a-patient-with-adenocarcinoma
#17
Takanori Suganuma, Han-Seung Yoon
We report a rare case of extensive esophageal squamous papillomas (ESPs) involving the entire esophagus and florid cardiac gland hyperplasia involving only the lower esophagus in a 39-year-old woman with heartburn and epigastric distress for the past 2 years. Previous esophagogastroduodenoscopy showed multiple ESPs involving the entire esophagus extending 38 cm from the esophageal orifice to the esophagogastric junction (EGJ). Additionally, prominent cardiac gland hyperplasia over the esophageal posterior wall was exhibited extending 12 cm from the mid-esophagus to the EGJ...
March 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29660156/evaluation-of-symptomatic-esophagogastric-junction-outflow-obstruction
#18
Andrew Ming Liang Ong, Vikneswaran Namasivayam, Yu Tien Wang
BACKGROUND: Esophagogastric junction outflow obstruction (EGJOO) may be due to anatomical abnormalities but it is unclear how to evaluate them after high resolution manometry (HRM). We aimed to determine 1) clinical and HRM parameters differentiating anatomical EGJOO from functional EGJOO, 2) investigations chosen and yield for anatomical EGJOO and 3) clinical outcomes of functional EGJOO. METHODS: Medical records of consecutive patients with symptomatic EGJOO from February 2012 to December 2015 were reviewed...
April 16, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29650836/-a-case-of-advanced-esophagogastric-junction-cancer-responding-to-s-1-neoadjuvant-chemotherapy
#19
Junko Kuroda, Hisae Aoki, Naoko Kondou, Toshiyuki Sumita, Kei Itoh, Senichirou Agawa
A 56-year-old man was diagnosed with advanced adenocarcinoma of the esophagogastric junction. He received 1 course of neoadjuvant chemotherapy with S-1. After neoadjuvant chemotherapy, the primary tumor showed a remarkable decrease in size. Subtotalesophagectomy, D2 lymph node dissection, and reconstruction with a gastric tube through the posterior mediastinal route were performed. Pathological examination showed that most of the cancer cells had been destroyed, with a part where adenocarcinoma mucosa was seen...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29644765/correlation-between-novel-3d-high-resolution-manometry-esophagogastric-junction-metrics-and-ph-metry-in-reflux-disease-patients
#20
Y Xiao, Z Lin, Y Li, J E Pandolfino, M Chen, P J Kahrilas
BACKGROUND AND AIMS: We recently developed 2 novel 3D high-resolution manometry (HRM) metrics of esophagogastric junction (EGJ) contractility to differentiate the lower esophageal sphincter (LES) and crural diaphragm (CD) elements of EGJ pressure. This study aimed to compare these metrics to the EGJ-contractile integral (EGJ-CI) and to analyze their correlation with esophageal acid exposure time (AET) on pH-metry. METHODS: Thirty-one gastro-oesophageal reflux disease (GERD) patients and 20 control subjects underwent 24-hour pH-metry and HRM using a 3D-HRM catheter...
April 11, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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