keyword
MENU ▼
Read by QxMD icon Read
search

ADE

keyword
https://www.readbyqxmd.com/read/27911695/dengue-virus-isolation-in-mosquito-aedes-albopictus-captured-during-an-outbreak-in-tokyo-2014-by-a-method-relying-on-antibody-dependent-enhancement-mechanism-using-fc%C3%AE-r-expressing-bhk-cells
#1
Meng Ling Moi, Daisuke Kobayashi, Haruhiko Isawa, Toshinori Sasaki, Masayuki Saijo, Ichiro Kurane, Kyoko Sawabe, Tomohiko Takasaki
Dengue virus (DENV) isolation from mosquitoes is necessary for providing definitive evidence of virus circulation, and is critical for further virological characterization and determination of epidemiological characteristics. By using Aedes albopictus mosquitoes captured during an outbreak in Tokyo in 2014, we compared the DENV isolation rates of a conventional virus isolation method that uses C6/36 mosquito cells as assay cells with those of a virus isolation method that relies on an antibody-dependent enhancement (ADE) mechanism by using FcγR-expressing baby hamster kidney (BHK) cells and an antibody with ADE activity...
December 2016: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/27909267/comparison-of-green-pit-viper-and-agkistrodon-halys-antivenom-in-inhibition-of-coagulopathy-due-to-trimeresurus-albolabris-venom-an-in-vitro-study-using-human-plasma
#2
S K Lam, S F Yip, P Crow, H T Fung, J Mh Cheng, K S Tan, O F Wong, D Yt Yeung, Y K Wong, K M Poon, G Ades
INTRODUCTION: There are two antivenoms that may be administered in Hong Kong following a bite by Trimeresurus albolabris: the green pit viper antivenom from the Thai Red Cross Society in Thailand and the Agkistrodon halys antivenom from the Shanghai Institute of Biological Products in China. Both are recommended by the Central Coordinating Committee of Accident and Emergency Services of the Hospital Authority for treating patients with a bite by Trimeresurus albolabris. The choice of which antivenom to use is based on physician preference...
December 2, 2016: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/27908746/willingness-to-pay-for-a-dengue-vaccine-and-its-associated-determinants-in-indonesia-a-community-based-cross-sectional-survey-in-aceh
#3
Harapan Harapan, Samsul Anwar, Aslam Bustamam, Arsil Radiansyah, Pradiba Angraini, Riny Fasli, Salwiyadi Salwiyadi, Reza Akbar Bastian, Ade Oktiviyari, Imaduddin Akmal, Muhammad Iqbalamin, Jamalul Adil, Fenni Henrizal, Darmayanti Darmayanti, Mahmuda Mahmuda, Mudatsir Mudatsir, Allison Imrie, R Tedjo Sasmono, Ulrich Kuch, Ziv Shkedy, Setia Pramana
Vaccination strategies are being considered as a part of dengue prevention programs in endemic countries. To accelerate the introduction of dengue vaccine into the public sector program and private markets, understanding the private economic benefits of a dengue vaccine is therefore essential. The aim of this study was to assess the willingness to pay (WTP) for a dengue vaccine among community members in Indonesia and its associated explanatory variables. A community-based, cross-sectional survey was conducted in nine regencies of Aceh province, Indonesia, from November 2014 to March 2015...
November 28, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27908402/microwave-assisted-biosynthesis-of-zinc-nanoparticles-and-their-cytotoxic-and-antioxidant-activity
#4
Zeinab Salari, Atefeh Ameri, Hamid Forootanfar, Mahboubeh Adeli-Sardou, Mandana Jafari, Mitra Mehrabani, Mojtaba Shakibaie
The present study was designed for microwave assisted synthesis of zinc nanoparticles (Zn NPs) using Lavandula vera leaf extract in the presence of ZnSO4 (1mM). The biogenic Zn NPs were then characterized using scanning electron microscopy (SEM), energy dispersive X-ray (EDX), X-ray diffraction spectroscopy (XRD), UV-visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR) techniques. Thereafter, the cytotoxic effect of ZnSO4 and Zn NPs on different cell lines was investigated by MTT-based cytotoxicity assay and their antioxidant properties were assessed using DPPH scavenging activity and reducing power assay...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27906714/central-nervous-system-regulation-of-hepatic-lipid-and-lipoprotein-metabolism
#5
Jennifer Taher, Sarah Farr, Khosrow Adeli
PURPOSE OF REVIEW: Hepatic lipid and lipoprotein metabolism is an important determinant of fasting dyslipidemia and the development of fatty liver disease. Although endocrine factors like insulin have known effects on hepatic lipid homeostasis, emerging evidence also supports a regulatory role for the central nervous system (CNS) and neuronal networks. This review summarizes evidence implicating a bidirectional liver-brain axis in maintaining metabolic lipid homeostasis, and discusses clinical implications in insulin-resistant states...
November 30, 2016: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/27902333/plant-produced-anti-dengue-virus-monoclonal-antibodies-exhibit-reduced-antibody-dependent-enhancement-of-infection-activity
#6
Matthew Dent, Jonathan Hurtado, Amber M Paul, Haiyan Sun, Huafang Lai, Ming Yang, Adrian Esqueda, Fengwei Bai, Herta Steinkellner, Qiang Chen
The monoclonal antibody (mAb) E60 has the potential to be a desirable therapeutic molecule since it efficiently neutralizes all four serotypes of dengue virus (DENV). However, mammalian cell-produced E60 exhibits antibody-dependent enhancement of infection (ADE) activity, rendering it inefficacious in vivo and subjects treated animals more susceptible to develop more severe diseases during secondary infection. In this study, we evaluated a plant-based expression system for the production of therapeutically suitable E60...
October 20, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27899954/phosphoethanolamine-and-the-danger-of-unproven-drugs
#7
Noam Pondé, Evandro de Azambuja, Felipe Ades
The use of unproven forms of therapy in cancer treatment is very common. In Brazil, the distribution by researchers to patients of an investigational agent called phophoethanolamine (PHOS) has led to a widely publicized scientific scandal. PHOS is a precursor to components of the cell membrane, with some published pre-clinical studies suggesting cytotoxic activity in cancer cells. The willingness of courts and of legislators to guarantee access to PHOS in spite of the lack of any clinical data and against the recommendations of scientific and medical organisations underscores the risks that unproven agents pose to regulatory authorities, health care systems and patients, and bears resemblance to other cases such as the controversy surrounding the approval of zidovudine for AIDS treatment by the FDA...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27897339/panchromatic-sequentially-cast-ternary-polymer-solar-cells
#8
Masoud Ghasemi, Long Ye, Qianqian Zhang, Liang Yan, Joo-Hyun Kim, Omar Awartani, Wei You, Abay Gadisa, Harald Ade
A sequential-casting ternary method is developed to create stratified bulk heterojunction (BHJ) solar cells, in which the two BHJ layers are spin cast sequentially without the need of adopting a middle electrode and orthogonal solvents. This method is found to be particularly useful for polymers that form a mechanically alloyed morphology due to the high degree of miscibility in the blend.
November 29, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27896144/clinical-decision-support-for-drug-related-events-moving-towards-better-prevention
#9
REVIEW
Sandra L Kane-Gill, Archita Achanta, John A Kellum, Steven M Handler
Clinical decision support (CDS) systems with automated alerts integrated into electronic medical records demonstrate efficacy for detecting medication errors (ME) and adverse drug events (ADEs). Critically ill patients are at increased risk for ME, ADEs and serious negative outcomes related to these events. Capitalizing on CDS to detect ME and prevent adverse drug related events has the potential to improve patient outcomes. The key to an effective medication safety surveillance system incorporating CDS is advancing the signals for alerts by using trajectory analyses to predict clinical events, instead of waiting for these events to occur...
November 4, 2016: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27894838/direct-and-indirect-costs-for-adverse-drug-events-identified-in-medical-records-across-care-levels-and-their-distribution-among-payers
#10
Jennie Natanaelsson, Katja M Hakkarainen, Staffan Hägg, Karolina Andersson Sundell, Max Petzold, Clas Rehnberg, Anna K Jönsson, Hanna Gyllensten
BACKGROUND: Adverse drug events (ADEs) cause considerable costs in hospitals. However, little is known about costs caused by ADEs outside hospitals, effects on productivity, and how the costs are distributed among payers. OBJECTIVE: To describe the direct and indirect costs caused by ADEs, and their distribution among payers. Furthermore, to describe the distribution of patient out-of-pocket costs and lost productivity caused by ADEs according to socio-economic characteristics...
November 19, 2016: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/27893177/efficient-charge-transfer-and-fine-tuned-energy-level-alignment-in-a-thf-processed-fullerene-free-organic-solar-cell-with-11-3-efficiency
#11
Zhong Zheng, Omar M Awartani, Bhoj Gautam, Delong Liu, Yunpeng Qin, Wanning Li, Alexander Bataller, Kenan Gundogdu, Harald Ade, Jianhui Hou
Fullerene-free organic solar cells show over 11% power conversion efficiency, processed by low toxic solvents. The applied donor and acceptor in the bulk heterojunction exhibit almost the same highest occupied molecular orbital level, yet exhibit very efficient charge creation.
November 28, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27890375/modifiable-determinants-of-attitude-towards-dengue-vaccination-among-healthy-inhabitants-of-aceh-indonesia-findings-from-a-community-based-survey
#12
Harapan Harapan, Samsul Anwar, Aslam Bustaman, Arsil Radiansyah, Pradiba Angraini, Riny Fasli, Salwiyadi Salwiyadi, Reza Akbar Bastian, Ade Oktiviyari, Imaduddin Akmal, Muhammad Iqbalamin, Jamalul Adil, Fenni Henrizal, Darmayanti Darmayanti, Rovy Pratama, Jhony Karunia Fajar, Abdul Malik Setiawan, Mandira Lamichhane Dhimal, Ulrich Kuch, David Alexander Groneberg, R Tedjo Sasmono, Meghnath Dhimal, Ruth Mueller
OBJECTIVE: To explore and understand the attitude towards dengue vaccination and its modifiable determinants among inhabitants of Aceh (northern Sumatra Island, Indonesia), the region that was most severely affected by the earthquake and tsunami of 26 December 2004. METHODS: A community-based, cross-sectional study was conducted among 535 healthy inhabitants in nine regencies (Kabupaten or Kotamadya) of Aceh that were selected randomly from November 2014 to March 2015...
November 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27884955/effect-of-exercise-induced-muscle-damage-on-vascular-function-and-skeletal-muscle-microvascular-deoxygenation
#13
Jacob T Caldwell, Garrett C Wardlow, Patrece A Branch, Macarena Ramos, Christopher D Black, Carl J Ade
This paper investigated the effects of unaccustomed eccentric exercise-induced muscle damage (EIMD) on macro- and microvascular function. We tested the hypotheses that resting local and systemic endothelial-dependent flow-mediated dilation (FMD) and microvascular reactivity would decrease, V˙O2max would be altered, and that during ramp exercise, peripheral O2 extraction, evaluated via near-infrared-derived spectroscopy (NIRS) derived deoxygenated hemoglobin + myoglobin ([HHb]), would be distorted following EIMD In 13 participants, measurements were performed prior to (Pre) and 48 h after a bout of knee extensor eccentric exercise designed to elicit localized muscle damage (Post)...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27883969/drug-drug-interactions-in-the-intensive-care-unit-do-they-really-matter
#14
D Vanham, A Spinewine, Ph Hantson, X Wittebole, D Wouters, B Sneyers
PURPOSE: To describe prevalence and patterns of potential drug-drug interactions (pDDIs) in the intensive care unit (ICU), occurrence of adverse drug events (ADEs), and agreement between different compendia and intensivists' perceptions. METHODS: A cross-sectional study. Drug profiles of all adult patients from 2 academic ICUs were screened on day 3 upon admission. We identified pDDIs using 3 compendia (Stockley's, Micromedex, and Epocrates) and documented their mechanism of action, clinical consequences, severity, level of evidence, and management...
October 4, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27881579/a-mirnas-dnmt1-axis-is-involved-in-azacitidine-resistance-and-predicts-survival-in-higher-risk-myelodysplastic-syndrome-and-low-blast-count-acute-myeloid-leukemia
#15
Françoise Solly, Catherine Koering, Aminetou Mint-Mohamed, Delphinne Maucort-Boulch, Guillaume Robert, Patrick Auberger, Pascale Flandrin-Gresta, Lionel Ades, Pierre Fenaux, Olivier Kosmider, Emmanuelle Tavernier-Tardy, Jerome Cornillon, Denis Guyotat, Lydia Lydia Campos, Franck Mortreux, Eric Wattel
PURPOSE: Azacitidine (AZA) inhibits DNA methyltransferases, including DNMT1, and is currently the standard of care for patients with higher risk myelodysplastic syndrome (HRMDS) or low blast count AML (AML). EXPERIMENTAL DESIGN: The expression of 754 microRNAs (miRNAs) was compared in AZA-resistant and AZA-sensitive MDS cells. We investigated the role of differentially expressed miRNAs on DNMT1 expression and AZA-resistance in vitro. We next evaluated anti-DNMT1 miRNAs expression in pretreatment bone marrow samples deriving from 75 patients treated with AZA for HRMDS or AML...
November 23, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27879313/international-registry-of-patients-carrying-tgfbr1-or-tgfbr2-mutations-results-of-the-montalcino-aortic-consortium
#16
Guillaume Jondeau, Jacques Ropers, Ellen Regalado, Alan Braverman, Arturo Evangelista, Guisela Teixido, Julie De Backer, Laura Muiño-Mosquera, Sophie Naudion, Cecile Zordan, Takayuki Morisaki, Hiroto Morisaki, Yskert Von Kodolitsch, Sophie Dupuis-Girod, Shaine A Morris, Richmond Jeremy, Sylvie Odent, Lesley C Adès, Madhura Bakshi, Katherine Holman, Scott LeMaire, Olivier Milleron, Maud Langeois, Myrtille Spentchian, Melodie Aubart, Catherine Boileau, Reed Pyeritz, Dianna M Milewicz
BACKGROUND: -The natural history of aortic diseases in patients with TGFBR1 or TGFBR2 mutations reported by different investigators has varied greatly. In particular, the current recommendations for the timing of surgical repair of the aortic root aneurysms may be overly aggressive. METHODS AND RESULTS: -The Montalcino Aortic Consortium, which includes 15 centers worldwide that specialize in heritable thoracic aortic diseases, was used to gather data on 441 patients from 228 families, with 176 cases harboring a mutation in TGBR1 and 265 in TGFBR2 Patients harboring a TGFBR1 mutation have similar survival rates (80% survival at 60 years), aortic risk (23% aortic dissection, 18% preventive aortic surgery), and prevalence of extra-aortic features (29% hypertelorism, 53% cervical arterial tortuosity, 27% wide scars) when compared to patients harboring a TGFBR2 mutation...
November 21, 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/27870313/hypothalamic-specific-proopiomelanocortin-deficiency-reduces-alcohol-drinking-in-male-and-female-mice
#17
Yan Zhou, Marcelo Rubinstein, Malcolm J Low, Mary Jeanne Kreek
Opioid receptor antagonist naltrexone reduces alcohol consumption and relapse in both humans and rodents. The present study investigated whether hypothalamic proopiomelanocortin (POMC) neurons (producing beta-endorphin and melanocortins) play a role in alcohol drinking behaviors. Both male and female mice with targeted deletion of two neuronal Pomc enhancers nPE1 and nPE2 (nPE-/-), resulting in hypothalamic-specific POMC deficiency, were studied in short-access (4-h/day) drinking-in-the-dark (DID, alcohol in one bottle), intermittent access (IA, 24-hour cycles of alcohol access every other day, alcohol vs...
November 21, 2016: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27867050/video-article-laparoscopic-resection-of-caesarean-scar-ectopic-pregnancy
#18
Alex Ades, Sneha Parghi
No abstract text is available yet for this article.
November 17, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27866801/microalgal-post-treatment-of-anaerobically-digested-agro-industrial-wastes-for-nutrient-removal-and-lipids-production
#19
Eleni Koutra, George Grammatikopoulos, Michael Kornaros
The aim of this study was to investigate the effectiveness of cultivating Parachlorella kessleri and Acutodesmus obliquus, in anaerobic digestion effluent (ADE) derived from the co-digestion of end-of-life dairy products with mixtures of agro-industrial wastes. To this end, their performance under sterile and non-sterile conditions and different ADE loadings was evaluated, in terms of biomass and lipid production, nutrient removal efficiency and vitality of the photosynthetic apparatus. 10% (v/v) ADE loading inhibited growth over 9-12days of cultivation, however biomass yields of 1...
November 17, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27865473/automated-data-extraction-merging-clinical-care-with-real-time-cohort-specific-research-and-quality-improvement-data
#20
Ferdynand Hebal, Elizabeth Nanney, Christine Stake, M L Miller, George Lales, Katherine A Barsness
BACKGROUND/PURPOSE: Although prohibitively labor intensive, manual data extraction (MDE) is the prevailing method used to obtain clinical research and quality improvement (QI) data. Automated data extraction (ADE) offers a powerful alternative. The purposes of this study were to 1) assess the feasibility of ADE from provider-authored outpatient documentation, and 2) evaluate the effectiveness of ADE compared to MDE. METHODS: A prospective collection of data was performed on 90 ADE-templated notes (N=71 patients) evaluated in our bowel management clinic...
November 3, 2016: Journal of Pediatric Surgery
keyword
keyword
38116
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"