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Tingting Wang, Jun Ma, Baoqi Yin, Xiaopeng Xing
We systematically studied the adsorption of O2 on Aun- in the size range of 0-1 nm at low temperatures, and determined new active sizes with n = 22, 24, 34, and 36. The kinetic measurements more clearly showed the correlation between the reactivity of Aun- with O2 and their electronic properties: the sizes with a close electron shell are always inert, and the sizes with a unpaired electron can chemically adsorb one O2 molecule if their adiabatic detachment energies (ADEs) are lower than a threshold around 3...
March 15, 2018: Journal of Physical Chemistry. A
Peter D Ehrenkranz, Jesus Mg Calleja, Wafaa El-Sadr, Ade O Fakoya, Nathan Ford, Anna Grimsrud, Kate L Harris, Suzanne L Jed, Daniel Low-Beer, Sadhna V Patel, Miriam Rabkin, William John Reidy, Annette Reinisch, George K Siberry, Leigh A Tally, Isaac Zulu, Irum Zaidi
INTRODUCTION: The World Health Organization's (WHO) recommendation of "Treat All" has accelerated the call for differentiated antiretroviral therapy (ART) delivery, a method of care that efficiently uses limited resources to increase access to HIV treatment. WHO has further recommended that stable individuals on ART receive refills every 3 to 6 months and attend clinical visits every 3 to 6 months. However, there is not yet consensus on how to ensure that the quality of services is maintained as countries strive to meet these standards...
March 2018: Journal of the International AIDS Society
Antonios Douros, Matthew Ades, Christel Renoux
BACKGROUND: Observational studies have suggested an increased risk of intracranial hemorrhage (ICH) associated with selective serotonin reuptake inhibitors (SSRIs) and other antidepressants primarily inhibiting serotonin reuptake. OBJECTIVES: Our aim was to systematically review the available epidemiologic evidence regarding the risk of ICH associated with SSRIs and antidepressants inhibiting serotonin reuptake. METHODS: MEDLINE/PubMed and EMBASE were searched for all relevant articles in English, French, or German published before April 2017...
March 13, 2018: CNS Drugs
Ashfaq Ali, Justine Penneroux, Reinaldo Dal Bello, Aline Massé, Samuel Quentin, Ashwin Unnikrishnan, Lucie Hernandez, Emmanuel Raffoux, Raouf Ben Abdelali, Aline Renneville, Claude Preudhomme, John Pimanda, Hervé Dombret, Jean Soulier, Pierre Fenaux, Emmanuelle Clappier, Lionel Adès, Alexandre Puissant, Raphael Itzykson
No abstract text is available yet for this article.
February 26, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Wanning Li, Long Ye, Sunsun Li, Huifeng Yao, Harald Ade, Jianhui Hou
Besides broadening of the absorption spectrum, modulating molecular energy levels, and other well-studied properties, a stronger intramolecular electron push-pull effect also affords other advantages in nonfullerene acceptors. A strong push-pull effect improves the dipole moment of the wings in IT-4F over IT-M and results in a lower miscibility than IT-M when blended with PBDB-TF. This feature leads to higher domain purity in the PBDB-TF:IT-4F blend and makes a contribution to the better photovoltaic performance...
March 13, 2018: Advanced Materials
Daniel K Burnell, Jie Xu, Scott K Hansen, Lawrence S Sims, Charles R Faust
Many studies indicate that small-scale heterogeneity and/or mobile-immobile mass exchange produce transient non-Fickian plume behavior that is not well captured by the use of the standard, deterministic advection-dispersion equation (ADE). An extended ADE modeling framework is presented here that is based on continuous time random walk (CTRW) theory. It can be used to characterize non-Fickian transport coupled with simultaneous sequential first-order reactions (e.g. biodegradation or radioactive decay) for multiple degrading contaminants such as chlorinated solvents, RDX, pesticides, and radionuclides...
March 13, 2018: Ground Water
Xia Dai, Zu-Chun Luo, Lu Zhai, Wen-Piao Zhao, Feng Huang
INTRODUCTION: Empagliflozin is a new, emerging oral hypoglycemic agent (OHA) which has shown significant benefits in type 2 diabetes mellitus (T2DM) patients with cardiovascular disease. In this analysis, our aim was to systematically compare the adverse drug events (ADEs) associated with a low (10 mg) versus a high (25 mg) dose of empagliflozin as (1) monotherapy, (2) as an add-on to other OHAs, and (3) as an add-on specifically to metformin, in patients who were treated for T2DM. METHODS: This was a systematic review and meta-analysis of randomized controlled trials that compared empagliflozin 10 mg versus 25 mg in patients who were treated for T2DM and which reported adverse drug reactions as their clinical endpoints...
March 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Michael Hornsey, David W Wareham
Multidrug-resistant lineages of Acinetobacter baumannii (MDRAB) are important nosocomial pathogens. As tigecycline remains active against most MDRAB we sought to investigate whether tigecycline resistance impacts biological fitness. The effects of treatment-emergent tigecycline resistance were investigated in vitro and in vivo using two pre- (AB210; W6976) and post-therapy (AB211; W7282) clinical pairs, recovered from individual patients, where tigecycline resistance was associated with up-regulated efflux activity...
March 9, 2018: Scientific Reports
Iris Ribitsch, Christian Peham, Nicole Ade, Julia Dürr, Stephan Handschuh, Johannes Peter Schramel, Claus Vogl, Heike Walles, Monika Egerbacher, Florien Jenner
Meniscal pathologies are among the most common injuries of the femorotibial joint in both human and equine patients. Pathological forces and ensuing injuries of the cranial horn of the equine medial meniscus are considered analogous to those observed in the human posterior medial horn. Biomechanical properties of human menisci are site- and depth- specific. However, the influence of equine meniscus topography and composition on its biomechanical properties is yet unknown. A better understanding of equine meniscus composition and biomechanics could advance not only veterinary therapies for meniscus degeneration or injuries, but also further substantiate the horse as suitable translational animal model for (human) meniscus tissue engineering...
2018: PloS One
Danilo O Carvalho, Samira Chuffi, Rafaella S Ioshino, Isabel C S Marques, Regina Fini, Maria Karina Costa, Helena R C Araújo, André L Costa-da-Silva, Bianca Burini Kojin, Margareth L Capurro
Ades aegypti is the most important arbovirus vector in the world, and new strategies are under evaluation. Biological studies mentioning the occurrence of a second mate in Aedes aegypti can interfere with vector control program planning, which involves male mosquito release technique. This study presents different experiments to show the occurrence of mixed progeny. Mixed male crosses (using a combination of different type of males in confinement with virgin females) showed no polyandric female. Individual crosses with male substitution in every gonotrophic cycle also did not show any polyandric female...
2018: PloS One
Li Wang, Gang Li, Ehsan Adeli, Mingxia Liu, Zhengwang Wu, Yu Meng, Weili Lin, Dinggang Shen
Tissue segmentation of infant brain MRIs with risk of autism is critically important for characterizing early brain development and identifying biomarkers. However, it is challenging due to low tissue contrast caused by inherent ongoing myelination and maturation. In particular, at around 6 months of age, the voxel intensities in both gray matter and white matter are within similar ranges, thus leading to the lowest image contrast in the first postnatal year. Previous studies typically employed intensity images and tentatively estimated tissue probabilities to train a sequence of classifiers for tissue segmentation...
March 8, 2018: Human Brain Mapping
Jiho Lee, Eunhye Kim, Yongho Shin, Junghak Lee, Jonghwa Lee, Joon-Kwan Moon, Hoon Choi, Wolfgang Maasfeld, Jeong-Han Kim
This study examined dermal and inhalation exposure of agricultural operators to kresoxim-methyl during pesticide mixing/loading and speed sprayer application (10 replicates, each of 3000 L of spray suspension) in an apple orchard and performed risk assessment. For the whole body dosimetry (WBD) exposure protocol, outer clothing, inner clothing, gauze, and nitrile gloves were examined to measure dermal exposure. In contrast, an IOM (institute of occupational medicine) sampler with a glass fiber filter was used to measure inhalation exposure...
March 3, 2018: Ecotoxicology and Environmental Safety
Frank E Muller-Karger, Erin Hestir, Christiana Ade, Kevin Turpie, Dar A Roberts, David Siegel, Robert J Miller, David Humm, Noam Izenberg, Mary Keller, Frank Morgan, Robert Frouin, Arnold G Dekker, Royal Gardner, James Goodman, Blake Schaeffer, Bryan A Franz, Nima Pahlevan, Antonio G Mannino, Javier A Concha, Steven G Ackleson, Kyle C Cavanaugh, Anastasia Romanou, Maria Tzortziou, Emmanuel S Boss, Ryan Pavlick, Anthony Freeman, Cecile S Rousseaux, John Dunne, Matthew C Long, Eduardo Klein, Galen A McKinley, Joachim Goes, Ricardo Letelier, Maria Kavanaugh, Mitchell Roffer, Astrid Bracher, Kevin R Arrigo, Heidi Dierssen, Xiaodong Zhang, Frank W Davis, Ben Best, Robert Guralnick, John Moisan, Heidi M Sosik, Raphael Kudela, Colleen B Mouw, Andrew H Barnard, Sherry Palacios, Collin Roesler, Evangelia G Drakou, Ward Appeltans, Walter Jetz
The biodiversity and high productivity of coastal terrestrial and aquatic habitats are the foundation for important benefits to human societies around the world. These globally distributed habitats need frequent and broad systematic assessments, but field surveys only cover a small fraction of these areas. Satellite-based sensors can repeatedly record the visible and near-infrared reflectance spectra that contain the absorption, scattering, and fluorescence signatures of functional phytoplankton groups, colored dissolved matter, and particulate matter near the surface ocean, and of biologically structured habitats (floating and emergent vegetation, benthic habitats like coral, seagrass, and algae)...
March 6, 2018: Ecological Applications: a Publication of the Ecological Society of America
Maria Cristina Angelici, Chiara Nardis, Riccardo Scarpelli, Paola Ade
In the reported case, a 41-year-old Italian man came to the clinician's observation reporting cramps, bloating and watery diarrhoea a few days after drinking water indicated as unpotable from a fountain in a farm area. The medical suspicion was directed at both gluten intolerance and enteric infection, eventually of waterborne origin. Gluten intolerance was investigated by intestinal biopsy and excluded, while stool analyses ruled out infective bacteriological or viral agents and parasites. Subsequently, a persistent eosinophilia was revealed and a parasitological analysis was again suggested, planning for a more sensitive molecular method...
March 2, 2018: New Microbiologica
Yan Zhou, Rachel Crowley, Thomas Prisinzano, Mary Jeanne Kreek
Alcohol relapse plays a major role in alcohol dependence and is an important focus for the treatment of alcoholism. The alcohol deprivation effect (ADE) is a widely used paradigm in rodents to model the relapse episodes that occur in human alcoholics. Mesyl Salvinorin B (MSB) is a potent and selective kappa opioid receptor (KOP-r) full agonist, with fewer side effects (e.g., sedation or anhedonia) than classic KOP-r full agonists and a longer duration of action in mice than the structurally similar salvinorin A...
February 26, 2018: Neuroscience Letters
Huafang Lai, Amber M Paul, Haiyan Sun, Junyun He, Ming Yang, Fengwei Bai, Qiang Chen
West Nile virus (WNV) has caused multiple global outbreaks with increased frequency of neuroinvasive disease in recent years. Despite many years of research, there are no licensed therapeutics or vaccines available for human use. One of the major impediments of vaccine development against WNV is the potential enhancement of infection by related flaviviruses in vaccinated subjects through the mechanism of antibody-dependent enhancement of infection (ADE). For instance, the recent finding of enhancement of Zika virus (ZIKV) infection by pre-exposure to WNV further complicates the development of WNV vaccines...
February 26, 2018: Vaccine
Khadijeh Soleimani, Abbas Dadkhah Tehrani, Mohsen Adeli
Slide ring hydrogels (SRHG) with supramolecular structures are a new class of hydrogels that contrary to the traditional hydrogels comprise dynamic cross-linking points. Herein, we reported on the fabrication of a new slide ring hydrogel through a very convenient one-pot approach. In this regard, isocyanate functionalized GO was synthesized and used as a stopper as well as cross-linker in the presence of a polypseudorotaxane of cyclodextrin threaded on poly(ethylene glycol) (PR). The surface of the resulting SRHG modified via graft polymerization with polyacrylamide (PAAm) and its application as a new type of absorbent for wastewater treatment was studied...
May 1, 2018: Carbohydrate Polymers
Harapan Harapan, Yogambigai Rajamoorthy, Samsul Anwar, Aslam Bustamam, Arsil Radiansyah, Pradiba Angraini, Riny Fasli, Salwiyadi Salwiyadi, Reza Akbar Bastian, Ade Oktiviyari, Imaduddin Akmal, Muhammad Iqbalamin, Jamalul Adil, Fenni Henrizal, Darmayanti Darmayanti, Rovy Pratama, Abdul Malik Setiawan, Mudatsir Mudatsir, Panji Fortuna Hadisoemarto, Mandira Lamichhane Dhimal, Ulrich Kuch, David Alexander Groneberg, Allison Imrie, Meghnath Dhimal, Ruth Müller
BACKGROUND: The Indonesian region of Aceh was the area most severely affected by the earthquake and tsunami of 26 December 2004. Department of Health data reveal an upward trend of dengue cases in Aceh since the events of the tsunami. Despite the increasing incidence of dengue in the region, there is limited understanding of dengue among the general population of Aceh. The aim of this study was to assess the knowledge, attitude, and practice (KAP) regarding dengue among the people of Aceh, Indonesia in order to design intervention strategies for an effective dengue prevention program...
February 27, 2018: BMC Infectious Diseases
Ade Kearns, Elise Whitley
This article examines whether perceived neighborhood ethnic diversity is associated with a range of social outcomes in a postindustrial city undergoing regeneration. The research included a survey in 3 types of deprived area in Glasgow: those undergoing regeneration, those directly adjoining regeneration areas, and those further removed from regeneration areas. In areas undergoing regeneration, perceived diversity was positively associated with many residential, cohesion, safety, and empowerment outcomes. This was also true, although to a lesser extent, in deprived areas at some distance from regeneration areas...
2018: Journal of Urban Affairs
Vadim Molodtsov, Elena Sineva, Lu Zhang, Xuhui Huang, Michael Cashel, Sarah E Ades, Katsuhiko S Murakami
DksA and ppGpp are the central players in the stringent response and mediate a complete reprogramming of the transcriptome. A major component of the response is a reduction in ribosome synthesis, which is accomplished by the synergistic action of DksA and ppGpp bound to RNA polymerase (RNAP) inhibiting transcription of rRNAs. Here, we report the X-ray crystal structures of Escherichia coli RNAP in complex with DksA alone and with ppGpp. The structures show that DksA accesses the template strand at the active site and the downstream DNA binding site of RNAP simultaneously and reveal that binding of the allosteric effector ppGpp reshapes the RNAP-DksA complex...
February 20, 2018: Molecular Cell
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