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https://www.readbyqxmd.com/read/28206645/ethnic-minority-musculoskeletal-health
#1
Ade Adebajo, Shahzad Shikoh, Kanta Kumar, David Walker
No abstract text is available yet for this article.
February 16, 2017: Rheumatology
https://www.readbyqxmd.com/read/28194127/interpersonal-coordination-and-individual-organization-combined-with-shared-phenomenological-experience-in-rowing-performance-two-case-studies
#2
Ludovic Seifert, Julien Lardy, Jérôme Bourbousson, David Adé, Antoine Nordez, Régis Thouvarecq, Jacques Saury
The principal aim of this study was to examine the impact of variability in interpersonal coordination and individual organization on rowing performance. The second aim was to analyze crew phenomenology in order to understand how rowers experience their joint actions when coping with constraints emerging from the race. We conducted a descriptive and exploratory study of two coxless pair crews during a 3000-m rowing race against the clock. As the investigation was performed in an ecological context, we postulated that our understanding of the behavioral dynamics of interpersonal coordination and individual organization and the variability in performance would be enriched through the analysis of crew phenomenology...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28183703/aup1-ancient-ubiquitous-protein-1-is-a-key-determinant-of-hepatic-very-low-density-lipoprotein-assembly-and-secretion
#3
Jing Zhang, Mostafa Zamani, Christoph Thiele, Jennifer Taher, Mohsen Amir Alipour, Zemin Yao, Khosrow Adeli
OBJECTIVE: AUP1 (ancient ubiquitous protein 1) is an endoplasmic reticulum-associated protein that also localizes to the surface of lipid droplets (LDs), with dual role in protein quality control and LD regulation. Here, we investigated the role of AUP1 in hepatic lipid mobilization and demonstrate critical roles in intracellular biogenesis of apoB100 (apolipoprotein B-100), LD mobilization, and very-low-density lipoprotein (VLDL) assembly and secretion. APPROACH AND RESULTS: siRNA knockdown of AUP1 significantly increased secretion of VLDL-sized apoB100-containing particles from HepG2 cells, correcting a key metabolic defect in these cells that normally do not secrete much VLDL...
February 9, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28179396/the-antigenic-structure-of-zika-virus-and-its-relation-to-other-flaviviruses-implications-for-infection-and-immunoprophylaxis
#4
REVIEW
Franz X Heinz, Karin Stiasny
Zika virus was discovered ∼70 years ago in Uganda and maintained a low profile as a human disease agent in Africa and Asia. Only recently has it caused explosive outbreaks in previously unaffected regions, first in Oceania and then in the Americas since 2015. Of special concern is the newly identified link between congenital malformations (especially microcephaly) and Zika virus infections during pregnancy. At present, it is unclear whether Zika virus changed its pathogenicity or whether the huge number of infections allowed the recognition of a previously cryptic pathogenic property...
March 2017: Microbiology and Molecular Biology Reviews: MMBR
https://www.readbyqxmd.com/read/28174169/altered-blood-flow-response-to-small-muscle-mass-exercise-in-cancer-survivors-treated-with-adjuvant-therapy
#5
Kaylin D Didier, Austin K Ederer, Landon K Reiter, Michael Brown, Rachel Hardy, Jacob Caldwell, Christopher Black, Michael G Bemben, Carl J Ade
BACKGROUND: Adjuvant cancer treatments have been shown to decrease cardiac function. In addition to changes in cardiovascular risk, there are several additional functional consequences including decreases in exercise capacity and increased incidence of cancer-related fatigue. However, the effects of adjuvant cancer treatment on peripheral vascular function during exercise in cancer survivors have not been well documented. We investigated the vascular responses to exercise in cancer survivors previously treated with adjuvant cancer therapies...
February 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28165179/controlled-covalent-functionalization-of-thermally-reduced-graphene-oxide-to-generate-defined-bifunctional-2d-nanomaterials
#6
Abbas Faghani, Ievgen S Donskyi, Mohammad Fardin Gholami, Benjamin Ziem, Andreas Lippitz, Wolfgang E S Unger, Christoph Böttcher, Jürgen P Rabe, Rainer Haag, Mohsen Adeli
A controlled, reproducible, gram-scale method is reported for the covalent functionalization of graphene sheets by a one-pot nitrene [2+1] cycloaddition reaction under mild conditions. The reaction between commercially available 2,4,6-trichloro-1,3,5-triazine and sodium azide with thermally reduced graphene oxide (TRGO) results in defined dichlorotriazine-functionalized sheets. The different reactivities of the chlorine substituents on the functionalized graphene allow stepwise post-modification by manipulating the temperature...
February 6, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28159465/a-comparison-of-sentinel-lymph-node-biopsy-to-lymphadenectomy-for-endometrial-cancer-staging-fires-trial-a-multicentre-prospective-cohort-study
#7
Emma C Rossi, Lynn D Kowalski, Jennifer Scalici, Leigh Cantrell, Kevin Schuler, Rabbie K Hanna, Michael Method, Melissa Ade, Anastasia Ivanova, John F Boggess
BACKGROUND: Sentinel-lymph-node mapping has been advocated as an alternative staging technique for endometrial cancer. The aim of this study was to measure the sensitivity and negative predictive value of sentinel-lymph-node mapping compared with the gold standard of complete lymphadenectomy in detecting metastatic disease for endometrial cancer. METHODS: In the FIRES multicentre, prospective, cohort study patients with clinical stage 1 endometrial cancer of all histologies and grades undergoing robotic staging were eligible for study inclusion...
January 31, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28159215/probiotic-and-antioxidant-properties-of-selenium-enriched-lactobacillus-brevis-lse-isolated-from-an-iranian-traditional-dairy-product
#8
Mojtaba Shakibaie, Tayebe Mohammadi-Khorsand, Mahboubeh Adeli-Sardou, Mandana Jafari, Sahar Amirpour-Rostami, Alieh Ameri, Hamid Forootanfar
The present study was designed to isolate a highly selenium-tolerant lactobacillus strain from an Iranian traditional dairy product named as Spar. Different criteria such as tolerance to the low pH, simulated gastric juice (SGJ), simulated intestinal juice (SIJ) and bile salts tolerance as well as Caco-2 cell adhesion assay were examined to evaluate the probiotic potentials of the selected isolate. Furthermore, the antioxidant properties of the isolate cultivated in medium containing and free of SeO3(2-) ions were evaluated using DPPH scavenging and reducing power assays...
March 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28156198/a-multicenter-record-review-of-in-hospital-adverse-drug-events-requiring-a-higher-level-of-care
#9
Kristel Marquet, Neree Claes, Elke De Troy, Gaby Kox, Martijn Droogmans, Arthur Vleugels
OBJECTIVE: Adverse drug events (ADEs) are a worldwide concern, particularly when leading to a higher level of care. This study defines a higher level of care as an unplanned (re)admission to an intensive care unit or an intervention by a Medical Emergency Team. The objectives are to describe the incidence and preventability of ADEs leading to a higher level of care, to assess the types of drug involved, and to identify the risk factors. METHODS: A three-stage retrospective review was performed in six Belgian hospitals...
February 3, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28153941/decreases-in-maximal-oxygen-uptake-following-long-duration-spaceflight-role-of-convective-and-diffusive-o2-transport-mechanisms
#10
Carl J Ade, Ryan M Broxterman, Alan Moore, Thomas J Barstow
We have previously predicted that the decrease in maximal oxygen uptake (VO2max) that accompanies time in microgravity reflects decrements in both convective and diffusive O2 transport to the mitochondria of the contracting myocytes. The aim of this investigation was therefore to quantify the relative changes in convective O2 transport (QO2) and O2 diffusing capacity (DO2) following long duration spaceflight. In 9 astronauts, resting hemoglobin concentration ([Hb]), VO2max, maximal cardiac output (QTmax), and differences in arterial and venous O2 contents (CaO2-CvO2) were obtained retrospectively for International Space Station Increments 19 through 33 (April 2009-November 2012)...
February 2, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28151718/the-prognostic-role-of-androgen-receptor-in-patients-with-early-stage-breast-cancer-a-meta-analysis-of-clinical-and-gene-expression-data
#11
Ivana Bozovic-Spasojevic, Dimitrios Zardavas, Sylvain Brohée, Lieveke Ameye, Debora Fumagalli, Felipe Ades, Evandro De Azambuja, Yacine Bareche, Martine Piccart, Marianne Paesmans, Christos Sotiriou
: Androgen receptor (AR) expression has been observed in about 70% of breast cancer (BC) patients, but its prognostic role remains uncertain. METHODS: To assess the prognostic role of AR expression in early-stage BC we performed a meta-analysis of studies that evaluated the impact of AR at the protein and gene expression level on disease free survival (DFS) and/or overall survival (OS). Eligible studies were identified by systematic review of electronic databases using the MeSH-terms "breast neoplasm" and "androgen receptor" and were selected after a qualitative assessment based on the REMARK criteria...
November 9, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28150505/reference-intervals-for-growth-arrest-specific-6-protein-in-adults
#12
Zeynep Cagman, Ozlem Bingol Ozakpinar, Zeynep Cirakli, Asuman Gedikbasi, Pinar Ay, David Colantonio, Ahmet Riza Uras, Khosrow Adeli, Fikriye Uras
The objective of this study was to establish reference intervals for growth arrest-specific 6 (GAS6), a vitamin K-dependent protein, in human adult plasma according to the Guideline of Clinical and Laboratory Standards Institute (CLSI) C28-A3. Blood samples were collected from 308 healthy volunteers aged 18-72 (157 female, 151 male). A non-parametric approach was used to calculate the reference interval. The plasma GAS6 reference interval was determined, with 90% confidence interval: the lower limit (2.5 percentile) was 2...
February 2, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28149967/3d-deep-learning-for-multi-modal-imaging-guided-survival-time-prediction-of-brain-tumor-patients
#13
Dong Nie, Han Zhang, Ehsan Adeli, Luyan Liu, Dinggang Shen
High-grade glioma is the most aggressive and severe brain tumor that leads to death of almost 50% patients in 1-2 years. Thus, accurate prognosis for glioma patients would provide essential guidelines for their treatment planning. Conventional survival prediction generally utilizes clinical information and limited handcrafted features from magnetic resonance images (MRI), which is often time consuming, laborious and subjective. In this paper, we propose using deep learning frameworks to automatically extract features from multi-modal preoperative brain images (i...
October 2016: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/28147525/structures-and-electronic-properties-of-b3sin-n-4-10-clusters-a-combined-ab-initio-and-experimental-study
#14
Xue Wu, Sheng-Jie Lu, Xiaoqing Liang, Xiaoming Huang, Ying Qin, Maodu Chen, Jijun Zhao, Hong-Guang Xu, R Bruce King, Weijun Zheng
The anionic silicon clusters doped with three boron atoms, B3Sin(-) (n = 4-10), have been generated by laser vaporization and investigated by anion photoelectron spectroscopy. The vertical detachment energies (VDEs) and adiabatic detachment energies (ADEs) of these anionic clusters are determined. The lowest energy structures of B3Sin(-) (n = 4-10) clusters are globally searched using genetic algorithm incorporated with density functional theory (DFT) calculations. The photoelectron spectra, VDEs, ADEs of these B3Sin(-) clusters (n = 4-10) are simulated using B3LYP/6-311+G(d) calculations...
January 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28146163/adherence-to-the-follow-up-of-the-newborn-exposed-to-syphilis-and-factors-associated-with-loss-to-follow-up
#15
Marjorie Cristiane Feliz, Adeli Regina Prizybicien, Andrea Maciel Rossoni, Tony Tahnus, Adriane Miro Vianna Benke Pereira, Cristina Rodrigues
Introduction: All newborns exposed to syphilis in pregnancy must have outpatient follow-up. The interruption of this follow-up especially threatens those children who were not treated at birth. Objective: To describe the clinical, epidemiological, and sociodemographic characteristics of pregnant women with syphilis and their newborns, and to investigate the factors associated with the discontinuation of the follow-up. Methods: This is an observational, descriptive, analytical, and retrospective study of medical records of 254 children exposed to syphilis, who were assisted at the Congenital Infectious Clinic of the university hospital of the Universidade Federal do Paraná, between 2000 and 2010...
October 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/28139966/japan-tobacco-international-to-be-the-most-successful-and-respected-tobacco-company-in-the-world
#16
Ross MacKenzie, Jappe Eckhardt, Ade Widyati Prastyani
Japan Tobacco International (JTI) is the international division of Japan Tobacco Incorporated, and the world's third largest transnational tobacco company. Founded in 1999, JTI's rapid growth has been the result of a global business strategy that potentially serves as a model for other Asian tobacco companies. This paper analyses Japan Tobacco Incorporated's global expansion since the 1980s in response to market opening, foreign competition, and declining share of a contracting domestic market. Key features of its global strategy include the on-going central role and investment by the Japanese government, and an expansion agenda based on mergers and acquisitions...
March 2017: Global Public Health
https://www.readbyqxmd.com/read/28134240/preserving-%C3%AF-conjugation-in-covalently-functionalized-carbon-nanotubes-for-optoelectronic-applications
#17
Antonio Setaro, Mohsen Adeli, Mareen Glaeske, Daniel Przyrembel, Timo Bisswanger, Georgy Gordeev, Federica Maschietto, Abbas Faghani, Beate Paulus, Martin Weinelt, Raul Arenal, Rainer Haag, Stephanie Reich
Covalent functionalization tailors carbon nanotubes for a wide range of applications in varying environments. Its strength and stability of attachment come at the price of degrading the carbon nanotubes sp(2) network and destroying the tubes electronic and optoelectronic features. Here we present a non-destructive, covalent, gram-scale functionalization of single-walled carbon nanotubes by a new [2+1] cycloaddition. The reaction rebuilds the extended π-network, thereby retaining the outstanding quantum optoelectronic properties of carbon nanotubes, including bright light emission at high degree of functionalization (1 group per 25 carbon atoms)...
January 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/28130022/improving-over-the-counter-medication-safety-for-older-adults-a-study-protocol-for-a-demonstration-and-dissemination-study
#18
Michelle A Chui, Jamie A Stone, Richard J Holden
BACKGROUND: Adverse drug events (ADEs) associated with over-the-counter (OTC) medications cause 178,000 hospitalizations each year. Older adults, aged 65 and older, are particularly vulnerable to ADEs. Of the 2.2 million older adults considered at risk for a major ADE, more than 50% are at risk due to concurrent use of an OTC and prescription medication. OBJECTIVES: To refine the intervention and implementation strategy through diagnostic and formative evaluation; to evaluate the effectiveness of the intervention for preventing misuse of high-risk OTC medications by older adults; and to evaluate the implementation of the intervention in community pharmacies...
January 24, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28126818/igg-antibodies-to-dengue-enhanced-for-fc%C3%AE-riiia-binding-determine-disease-severity
#19
Taia T Wang, Jaturong Sewatanon, Matthew J Memoli, Jens Wrammert, Stylianos Bournazos, Siddhartha Kumar Bhaumik, Benjamin A Pinsky, Kulkanya Chokephaibulkit, Nattawat Onlamoon, Kovit Pattanapanyasat, Jeffery K Taubenberger, Rafi Ahmed, Jeffrey V Ravetch
Dengue virus (DENV) infection in the presence of reactive, non-neutralizing immunoglobulin G (IgG) (RNNIg) is the greatest risk factor for dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Progression to DHF/DSS is attributed to antibody-dependent enhancement (ADE); however, because only a fraction of infections occurring in the presence of RNNIg advance to DHF/DSS, the presence of RNNIg alone cannot account for disease severity. We discovered that DHF/DSS patients respond to infection by producing IgGs with enhanced affinity for the activating Fc receptor FcγRIIIA due to afucosylated Fc glycans and IgG1 subclass...
January 27, 2017: Science
https://www.readbyqxmd.com/read/28125608/post-marketing-safety-surveillance-of-the-salvia-miltiorrhiza-depside-salt-for-infusion-a-real-world-study
#20
Ying-Ying Yan, Yi-Heng Yang, Wei-Wei Wang, Yu-Ting Pan, Si-Yan Zhan, Ming-Yang Sun, Hong Zhang, Suo-Di Zhai
BACKGROUND: Salvia Miltiorrhiza Depside Salt for Infusion (SMDS) is made of a group of highly purified listed drugs. However, its safety data is still reported limitedly. Compared with the clinical trials, its safety in the real world setting is barely assessed. OBJECTIVE: To investigate the safety issues, including adverse events (AEs), adverse events related to SMDS (ADEs), and adverse drug reactions (ADRs) of the SMDS in the real world clinical practice. METHODS: This is a prospective, multicenter, pharmacist-led, cohort study in the real world setting...
2017: PloS One
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