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https://www.readbyqxmd.com/read/28099789/ehr-related-medication-errors-in-two-icus
#1
Pascale Carayon, Shimeng Du, Roger Brown, Randi Cartmill, Mark Johnson, Tosha B Wetterneck
The objective of this study was to describe the frequency, potential harm, and nature of electronic health record (EHR)-related medication errors in intensive care units (ICUs). Using a secondary data analysis of a large database of medication safety events collected in a study on EHR technology in ICUs, we assessed the EHR relatedness of a total of 1622 potential preventable adverse drug events (ADEs) identified in a sample of 624 patients in 2 ICUs of a medical center. Thirty-four percent of the medication events were found to be EHR related...
January 2017: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
https://www.readbyqxmd.com/read/28090318/dengue-virus-antibodies-enhance-zika-virus-infection
#2
Lauren M Paul, Eric R Carlin, Meagan M Jenkins, Amanda L Tan, Carolyn M Barcellona, Cindo O Nicholson, Scott F Michael, Sharon Isern
For decades, human infections with Zika virus (ZIKV), a mosquito-transmitted flavivirus, were sporadic, associated with mild disease, and went underreported since symptoms were similar to other acute febrile diseases. Recent reports of severe disease associated with ZIKV have greatly heightened awareness. It is anticipated that ZIKV will continue to spread in the Americas and globally where competent Aedes mosquito vectors are found. Dengue virus (DENV), the most common mosquito-transmitted human flavivirus, is both well-established and the source of outbreaks in areas of recent ZIKV introduction...
December 2016: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/28074750/physician-perceptions-of-consultant-pharmacist-services-associated-with-an-intervention-for-adverse-drug-events-in-the-nursing-facility
#3
Sandra L Kane-Gill, Joseph T Hanlon, Michael J Fine, Subashan Perera, Colleen M Culley, Stephanie A Studenski, Dave A Nace, Richard D Boyce, Nicholas G Castle, Steven M Handler
OBJECTIVE: To assess the importance and performance of consultant pharmacist services delivered before and after an intervention to detect and manage adverse drug events among nursing facility residents. DESIGN: Before and after intervention survey of physicians participating in a randomized, controlled trial. SETTING: Four nonprofit, academically affiliated nursing facilities. PARTICIPANTS: Attending physicians providing nursing facility care who were randomized to intervention or control groups...
December 1, 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28063785/effect-of-socioeconomic-status-on-propensity-to-change-risk-behaviors-following-myocardial-infarction-implications-for-healthy-lifestyle-medicine
#4
REVIEW
Diann E Gaalema, Rebecca J Elliott, Zachary H Morford, Stephen T Higgins, Philip A Ades
INTRODUCTION: Failure to change risk behaviors following myocardial infarction (MI) increases the likelihood of recurrent MI and death. Lower-socioeconomic status (SES) patients are more likely to engage in high-risk behaviors prior to MI. Less well known is whether propensity to change risk behaviors after MI also varies inversely with SES. METHODS: We performed a systematized literature review addressing changes in risk behaviors following MI as a function of SES...
January 4, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28062393/proportion-of-tubal-factor-infertility-due-to-chlamydia-finite-mixture-modeling-of-serum-antibody-titers
#5
A E Ades, M J Price, D Kounali, V A Akande, G S Wills, M O McClure, P Muir, P J Horner
In this study, we examined whether the proportion of tubal factor infertility (TFI) that is attributable to Chlamydia trachomatis, the population excess fraction (PEF), can be estimated from serological data using finite mixture modeling. Whole-cell inclusion immunofluorescence serum antibody titers were recorded among infertile women seen at St. Michael's Hospital in Bristol, United Kingdom, during the period 1985-1995. Women were classified as TFI cases or controls based on laparoscopic examination. Finite mixture models were used to identify the number of component titer distributions and the proportion of serum samples in each, from which estimates of PEF were derived...
January 6, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28061457/prognostic-roles-of-mrna-expression-of-notch-receptors-in-non-small-cell-lung-cancer
#6
Jianwen Xiong, Xiaoqiang Zhang, Xianglai Chen, Yiping Wei, De-Guo Lu, Yun-Wei Han, Jianjun Xu, Dongliang Yu
Notch signalling is aberrantly activated in human non-small cell lung cancer (NSCLC). Nevertheless, the prognostic roles of mRNA expression of four Notch receptors in NSCLC patients remain elusive. In this report, we reported the prognostic roles of Notch receptors in a total of 1,926 NSCLC patients through "The Kaplan-Meier plotter" (KM plotter) database which is capable to assess the effect of 22,277 genes on survival of NSCLC patients. We found that mRNA high expression level of Notch1 was associated with better overall survival (OS) for all NSCLC patients, hazard ratio (HR) 0...
January 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28060051/e-prescribing-and-adverse-drug-events-an-observational-study-of-the-medicare-part-d-population-with-diabetes
#7
Meghan Hufstader Gabriel, Christopher Powers, William Encinosa, Julie P W Bynum
BACKGROUND: Although the adoption of e-prescriptions among physicians has increased substantially under the Medicare Improvements for Patients and Providers Act and Meaningful Use programs, little is known of its impact on patient outcomes. OBJECTIVE: To examine the impact of e-prescribing on emergency visits or hospitalizations for diabetes-related adverse drug events (ADEs) including hypoglycemia. DESIGN: This is a prospective, observational cohort study with patient fixed effects...
January 3, 2017: Medical Care
https://www.readbyqxmd.com/read/28059242/multi-octave-metamaterial-reflective-half-wave-plate-for-millimeter-and-sub-millimeter-wave-applications
#8
Giampaolo Pisano, Bruno Maffei, Peter A R Ade, Paolo de Bernardis, Peter de Maagt, Brian Ellison, Manju Henry, Ming Wah Ng, Brian Schortt, Carole Tucker
The quasi-optical modulation of linear polarization at millimeter and sub-millimeter wavelengths can be achieved by using rotating half-wave plates (HWPs) in front of polarization-sensitive detectors. Large operational bandwidths are required when the same device is meant to work simultaneously across different frequency bands. Previous realizations of half-wave plates, ranging from birefringent multi-plates to mesh-based devices, have achieved bandwidths of the order of 100%. Here we present the design and experimental characterization of a reflective HWP able to work across bandwidths of the order of 150%...
December 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/28039373/a-model-of-the-superior-colliculus-predicts-fixation-locations-during-scene-viewing-and-visual-search
#9
Hossein Adeli, Françoise Vitu, Gregory J Zelinsky
: Modern computational models of attention predict fixations using saliency maps and target maps, which prioritize locations for fixation based on feature contrast and target goals, respectively. But while many such models are biologically plausible, none have looked to the oculomotor system for design constraints or parameter specification. Conversely, while most models of saccade programming are tightly coupled to underlying neurophysiology, none have been tested using real-world stimuli and tasks...
December 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28039355/dengue-virus-denv-specific-antibodies-enhance-brazilian-zika-virus-zikv-infection
#10
Priscila Ms Castanha, Eduardo J M Nascimento, Braga Cynthia, Marli T Cordeiro, Otávio V de Carvalho, Leila R de Mendonça, Elisa An Azevedo, Rafael Fo França, Dhalia Rafael, Ernesto Ta Marques
Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in FcγRII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need of epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complications associated with Zika virus infections...
December 29, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28036370/fc%C3%AE-receptor-iia-mediated-src-signaling-pathway-is-essential-for-the-antibody-dependent-enhancement-of-ebola-virus-infection
#11
Wakako Furuyama, Andrea Marzi, Aaron B Carmody, Junki Maruyama, Makoto Kuroda, Hiroko Miyamoto, Asuka Nanbo, Rashid Manzoor, Reiko Yoshida, Manabu Igarashi, Heinz Feldmann, Ayato Takada
Antibody-dependent enhancement (ADE) of Ebola virus (EBOV) infection has been demonstrated in vitro, raising concerns about the detrimental potential of some anti-EBOV antibodies. ADE has been described for many viruses and mostly depends on the cross-linking of virus-antibody complexes to cell surface Fc receptors, leading to enhanced infection. However, little is known about the molecular mechanisms underlying this phenomenon. Here we show that Fcγ-receptor IIa (FcγRIIa)-mediated intracellular signaling through Src family protein tyrosine kinases (PTKs) is required for ADE of EBOV infection...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/28034993/lenalidomide-combined-with-intensive-chemotherapy-in-acute-myeloid-leukemia-and-higher-risk-myelodysplastic-syndrome-with-5q-deletion-results-of-a-phase-ii-study-by-the-groupe-francophone-des-myelodysplasies
#12
Lionel Ades, Thomas Prebet, Aspasia Stamatoullas, Christian Recher, Romain Guieze, Emmanuel Raffoux, Krimo Bouabdallah, Mathilde Hunault, Eric Wattel, Laure Stalnikiewicz, Andrea Toma, Herve' Dombret, Nobert Vey, Marie Sebert, Claude Gardin, Cendrine Chaffaut, Sylvie Chevret, Pierre Fenaux
Patients with acute myeloblastic leukemia or higher risk myelodysplastic syndromes with 5q deletion (generally within complex karyotype) respond poorly to intensive chemotherapy and have very poor survival. In this population, we evaluated escalating doses of lenalidomide combined with IC in a phase II study (NCT00885508) Treatment consisted of daunorubicin (45 mg/m2/d1-3 in cohort 1, escalated to 60mg/m2/1-3 in cohorts2 and 3) combined with AraC (200mg/m2/ d1-7) and lenalidomide (10mg/d1-21 in cohorts1 and 2, escalated to 25mg/d1-21 in cohort 3)...
December 29, 2016: Haematologica
https://www.readbyqxmd.com/read/28033166/patient-characteristics-predictive-of-cardiac-rehabilitation-adherence
#13
Diann E Gaalema, Patrick D Savage, Jason L Rengo, Alex Y Cutler, Rebecca J Elliott, Jeffrey S Priest, Stephen T Higgins, Philip A Ades
PURPOSE: Cardiac rehabilitation (CR) is a program of structured exercise and interventions for coronary risk factor reduction that reduces morbidity and mortality rates following a major cardiac event. Although a dose-response relationship between the number of CR sessions completed and health outcomes has been demonstrated, adherence with CR is not high. In this study, we examined associations between the number of sessions completed within CR and patient demographics, clinical characteristics, smoking status, and socioeconomic status (SES)...
December 28, 2016: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28032216/effectiveness-of-aprepitant-in-addition-to-ondansetron-in-the-prevention-of-nausea-and-vomiting-caused-by-fractionated-radiotherapy-to-the-upper-abdomen-avert
#14
Steven Ades, M Halyard, K Wilson, T Ashikaga, R Heimann, S Kumar, W Blackstock
PURPOSE: Despite a lower risk of nausea and vomiting in patients receiving radiotherapy to the upper abdomen (UA-RINV) with prophylactic 5-HT3 antagonist therapy, patients can still experience UA-RINV. The aim of this multicenter phase II study was to assess effectiveness, safety, and tolerability of protracted dual NK1-receptor and 5-HT3 antagonist prophylaxis against UA-RINV. METHODS: Patients receiving fractionated radiotherapy with radiosensitizing chemotherapy received oral ondansetron 8 mg po q12 h and aprepitant 125/80/80 mg on a Monday, Wednesday, Friday schedules throughout radiotherapy...
December 28, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28031301/social-mobilization-and-community-engagement-central-to-the-ebola-response-in-west-africa-lessons-for-future-public-health-emergencies
#15
Amaya M Gillespie, Rafael Obregon, Rania El Asawi, Catherine Richey, Erma Manoncourt, Kshiitij Joshi, Savita Naqvi, Ade Pouye, Naqibullah Safi, Ketan Chitnis, Sabeeha Quereshi
Following the World Health Organization (WHO) declaration of a Public Health Emergency of International Concern regarding the Ebola outbreak in West Africa in July 2014, UNICEF was asked to co-lead, in coordination with WHO and the ministries of health of affected countries, the communication and social mobilization component-which UNICEF refers to as communication for development (C4D)-of the Ebola response. For the first time in an emergency setting, C4D was formally incorporated into each country's national response, alongside more typical components such as supplies and logistics, surveillance, and clinical care...
December 23, 2016: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28025363/national-action-plan-for-adverse-drug-event-prevention-recommendations-for-safer-outpatient-opioid-use
#16
Aaron R Ducoffe, Andrew York, Dale J Hu, Deborah Perfetto, Robert D Kerns
Adverse drug events (ADEs) have been highlighted as a major patient safety and public health challenge by the National Action Plan for Adverse Drug Event Prevention (ADE Action Plan), which was released by the Office of Disease Prevention and Health Promotion (ODPHP) in August 2014. The ADE Action Plan focuses on surveillance, evidence-based prevention, incentives, and oversights, additional research needs as well as possible measures and metrics to track progress of ADE prevention within three drug classes: anticoagulants, diabetes agents, and opioids...
December 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28008969/determination-of-equilibrium-dissociation-constants-for-recombinant-antibodies-by-high-throughput-affinity-electrophoresis
#17
Yuchen Pan, Eric K Sackmann, Karolina Wypisniak, Michael Hornsby, Sammy S Datwani, Amy E Herr
High-quality immunoreagents enhance the performance and reproducibility of immunoassays and, in turn, the quality of both biological and clinical measurements. High quality recombinant immunoreagents are generated using antibody-phage display. One metric of antibody quality - the binding affinity - is quantified through the dissociation constant (KD) of each recombinant antibody and the target antigen. To characterize the KD of recombinant antibodies and target antigen, we introduce affinity electrophoretic mobility shift assays (EMSAs) in a high-throughput format suitable for small volume samples...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28002420/the-impact-of-the-newly-licensed-dengue-vaccine-in-endemic-countries
#18
Maíra Aguiar, Nico Stollenwerk, Scott B Halstead
BACKGROUND: With approximately 3 billion people at risk of acquiring the infection, dengue fever is now considered the most important mosquito-borne viral disease in the world, with 390 million dengue infections occurring every year, of which 96 million manifest symptoms with any level of disease severity. Treatment of uncomplicated dengue cases is only supportive and severe dengue cases require hospital intensive care. A vaccine now licensed in several countries and developed by Sanofi Pasteur (CYD-TDV, named Dengvaxia), was able to protect, in the first 25 months of the two Phase III, 66% of a subset of 9-16 year old participants...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28002341/salvianolate-injection-in-the-treatment-of-unstable-angina-pectoris-a-systematic-review-and-meta-analysis
#19
Dan Zhang, Jiarui Wu, Shi Liu, Xiaomeng Zhang, Bing Zhang
BACKGROUND: To systematically evaluate the clinical efficacy and safety of Salvianolate injection in the treatment of unstable angina pectoris (UAP). METHODS: Using literature databases, we conducted a thorough and systematic retrieval of randomized controlled trials (RCTs) that using Salvianolate injection for treating UAP. The Cochrane Risk of Bias Assessment Tool was used to evaluate the methodological quality of the RCTs, and then the data were extracted and meta-analyzed by RevMan5...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27989738/incidence-characteristics-and-survival-following-cardiopulmonary-resuscitation-in-the-quaternary-neonatal-intensive-care-unit
#20
Elizabeth E Foglia, Robert Langeveld, Lauren Heimall, Alyson Deveney, Anne Ades, Erik A Jensen, Vinay M Nadkarni
BACKGROUND: The contemporary characteristics and outcomes of cardiopulmonary resuscitation (CPR) in the neonatal intensive care unit (NICU) are poorly described. The objectives of this study were to determine the incidence, interventions, and outcomes of CPR in a quaternary referral NICU. METHODS: Retrospective observational study of infants who received chest compressions for resuscitation in the Children's Hospital of Philadelphia NICU between April 1, 2011 and June 30, 2015...
October 27, 2016: Resuscitation
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