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Low level laser therapy

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https://www.readbyqxmd.com/read/28428016/the-role-of-low-level-laser-therapy-on-neuropathic-pain-relief-and-interleukin-6-expression-following-spinal-cord-injury-an-experimental-study
#1
Negin Mojarad, Atousa Janzadeh, Mahmoud Yousefifard, Farinaz Nasirinezhad
INTRODUCTION: The effect of Low Level Laser Therapy (LLLT) as a non-invasive treatment of spinal cord injury (SCI) is still under investigation. Therefore, the present study aimed to evaluate the effectiveness of LLLT on neuropathic pain and interleukin-6 (IL-6) expression following SCI in male rats. METHODS: 46 adult male rats were divided into 5 groups of control, SCI, treatment with methylprednisolone sodium succinate (MPSS), 1-week LLLT and 2-week LLLT. Animals underwent behavioral evaluations for motor behavior, level of allodynia and hyperalgesia every week...
April 17, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28427069/practical-lessons-from-protocol-i-for-the-management-of-diabetic-macular-edema
#2
Lekha Mukkamala, Neelakshi Bhagat, Marco A Zarbin
Protocol I, a multicenter randomized clinical trial, compared the visual outcomes of patients treated with 0.5 mg intravitreal ranibizumab with either prompt or deferred (by 24 weeks laser), 4 mg intravitreal triamcinolone with prompt laser, or sham injection with prompt laser for the treatment of center-involving diabetic macular edema (DME). A total of 854 adult patients with type I or II diabetes and any level of non-proliferative diabetic retinopathy or proliferative retinopathy with adequate panretinal photocoagulation, with best-corrected visual acuity (BCVA) of 78 to 24 ETDRS letters (Snellen equivalent of 20/32 to 20/320) and visual loss attributed to macular edema, or retinal thickening with central subfield thickness of at least 250 µm by OCT were enrolled...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28422520/low-level-laser-therapy-improves-performance-and-reduces-fatigue-in-competitive-cyclists
#3
Fábio J Lanferdini, Rodrigo R Bini, Bruno M Baroni, Kelli D Klein, Felipe P Carpes, Marco A Vaz
Evidence supports that low-level laser therapy (LLLT) minimizes fatigue effects on muscle performance. However, the ideal LLLT dosage to improve athletes' performance during sports activities, such as cycling, is still unclear. Therefore, the goal of this study was to investigate the effects of different LLLT dosages on cyclists' performance in time-to-exhaustion tests. In addition, we looked at the effects of LLLT on the frequency content of the EMG signals to assess fatigue mechanisms. Twenty male competitive cyclists participated in a crossover, randomized, double-blind and placebo-controlled trial...
April 19, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28401348/ultrapulsed-fractional-ablative-carbon-dioxide-laser-treatment-of-hypertrophic-burn-scars-evaluation-of-an-in-patient-controlled-standardized-treatment-approach
#4
Julian Poetschke, Ulf Dornseifer, Matteo Tretti Clementoni, Markus Reinholz, Hannah Schwaiger, Stephanie Steckmeier, Thomas Ruzicka, Gerd G Gauglitz
In this study, we aimed to quantify the effects of fractional ablative carbon dioxide laser therapy in the treatment of widespread hypertrophic burn scars. While many different pilot studies have described the potential of the technology and expert groups and current guidelines, alike, recommend its use, the level of evidence for the efficacy of fractional CO2-laser treatment for burn scars is currently very low. Ten patients (three male, seven female) with hypertrophic burn scars were treated with a single course of fractional CO2-laser therapy in an in-patient controlled setup, using a standardized treatment paradigm...
April 12, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28396101/the-effectiveness-of-treatments-for-androgenetic-alopecia-a-systematic-review-and-meta-analysis
#5
REVIEW
Areej Adil, Marshall Godwin
BACKGROUND: Androgenetic alopecia, or male pattern hair loss, is a hair loss disorder mediated by dihydrotestosterone, the potent form of testosterone. Currently, minoxidil and finasteride are Food and Drug Administration (FDA)-approved, and HairMax LaserComb, which is FDA-cleared, are the only treatments recognized by the FDA as treatments of androgenetic alopecia. OBJECTIVE: This systematic review and meta-analysis assesses the efficacy of nonsurgical treatments of androgenetic alopecia in comparison to placebo for improving hair density, thickness, growth (defined by an increased anagen:telogen ratio), or subjective global assessments done by patients and investigators...
April 7, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28394081/the-effect-of-low-level-laser-therapy-as-an-adjunct-to-non-surgical-periodontal-treatment-on-gingival-crevicular-fluid-levels-of-transforming-growth-factor-beta-1-tissue-plasminogen-activator-and-plasminogen-activator-inhibitor-1-in-smoking-and-non-smoking
#6
F Pamuk, M Lütfioğlu, A Aydoğdu, C Z Koyuncuoglu, E Cifcibasi, O S Badur
BACKGROUND AND OBJECTIVE: This study aimed to investigate the effects of low-level laser therapy (LLLT) as an adjunct to scaling and root planing (SRP) on smoking and non-smoking patients with chronic periodontitis. MATERIAL AND METHODS: The study was conducted using a split-mouth design with 30 patients with chronic periodontitis (15 smokers, 15 non-smokers) and 30 healthy individuals matched for age, sex and smoking status as controls. Groups were constituted as follows: Cp+SRP+Sham: non-smokers with chronic periodontitis treated with SRP; Cp+SRP+LLLT: non-smokers with chronic periodontitis treated with SRP+LLLT; SCp+SRP+Sham: smokers with chronic periodontitis treated with SRP; SCp+SRP+LLLT: smokers with chronic periodontitis treated with SRP+LLLT; C: control group comprised of periodontally healthy non-smokers; SC: control group comprised of periodontally healthy smokers...
April 10, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28391087/effects-of-two-wattages-of-low-level-laser-therapy-on-orthodontic-tooth-movement
#7
M Milligan, Y Arudchelvan, S-G Gong
INTRODUCTION: Mixed outcomes have been found in animal and clinical studies with regard to the use of low-level laser therapy (LLLT) as a modality to accelerate orthodontic tooth movement (OTM). One major reason for the variable findings is the different methodologies and protocols for laser therapy use. OBJECTIVE: The aim of this study was to determine whether orthodontically moved molars exposed to two different wattages at the same energy density of LLLT exhibited differences in the amount of tooth movement and molecular and histological changes in the adjacent periodontal areas...
March 24, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28382433/apoptosis-induced-by-low-level-laser-in-polymorphonuclear-cells-of-acute-joint-inflammation-comparative-analysis-of-two-energy-densities
#8
Lúcia Mara Januário Dos Anjos, Adenilson de Souza da Fonseca, Jacy Gameiro, Flávia de Paoli
Anti-inflammatory property of low-level laser therapy (LLLT) has been widely described in literature, although action mechanisms are not always clarified. Thus, this study aimed to evaluate apoptosis mechanisms in the LLLT anti-inflammatory effects on the arthritis experimental model in vivo at two different energy densities (3 and 30 Jcm(-2)). Arthritis was induced in mice by zymosan solution, animals were distributed into five groups, and morphological analysis, immunocytochemistry and gene expressions for apoptotic proteins were performed...
April 5, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28377600/low-level-laser-facilitates-alternatively-activated-macrophage-microglia-polarization-and-promotes-functional-recovery-after-crush-spinal-cord-injury-in-rats
#9
Ji Wei Song, Kun Li, Zhuo Wen Liang, Chen Dai, Xue Feng Shen, Yu Ze Gong, Shuang Wang, Xue Yu Hu, Zhe Wang
Macrophages and resident microglia play an import role in the secondary neuroinflammation response following spinal cord injury. Reprogramming of macrophage/microglia polarization is an import strategy for spinal cord injury restoration. Low-level laser therapy (LLLT) is a noninvasive treatment that has been widely used in neurotrauma and neurodegenerative diseases. However, the influence of low-level laser on polarization of macrophage/microglia following spinal cord injury remains unknown. The present study applied low-level laser therapy on a crush spinal cord injury rat model...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28371519/evaluation-of-the-bony-repair-in-rat-cranial-defect-using-near-infrared-reflectance-spectroscopy-and-discriminant-analysis
#10
Leomir A S de Lima, Kássio M G Lima, Lana S S de Oliveira, Aurigena A Araújo, Raimundo Fernandes de Araújo Junior
We set out to determine whether near infrared reflectance spectroscopy (NIRS) combined with principal component analysis-linear discriminant analysis (LDA) or, variable selection techniques employing successive projection algorithm or genetic algorithm (GA) could evaluate the bone repair in cranial critical-size (5 mm) defect after stimulation with collagen sponge scaffold and/or infrared low-level laser therapy directly on the local. Forty-five Winstar rats were divided into nine groups of five each, namely: group H - healthy, n = 5 (without treatment and without cranial critical-size defect), (GI positive control - n = 5, 21 days or n = 5, 30 days) without treatment and with cranial critical-size defect; (GII-n = 5, 21 days or n = 5, 30 days) cranial critical-size defect filled with collagen sponge scaffold; (GIII-n = 5, 21 days or n = 5, 30 days) cranial critical-size defect submitted to low-level laser therapy; (GIV-n = 5, 21 days or n = 5, 30 days) cranial critical-size defect submitted to combined collagen sponge scaffold + low-level laser therapy treatment...
April 3, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28365423/evaluation-of-theranostic-nanocarriers-for-near-infrared-imaging-and-photodynamic-therapy-on-human-prostate-cancer-cells
#11
Fernanda Z Leandro, Júlia Martins, Aparecida M Fontes, Antonio C Tedesco
This paper evaluates how effectively chloroaluminum phthalocyanine (ClAlPc) entrapped in colloidal nanocarriers, such as nanocapsule (NC) and nanoemulsion (NE), induces photodamage in human prostate cancer cells (LNCaP) during photodynamic therapy (PDT). The MTT cell viability assay showed that both ClAlPc-NC and ClAlPc-NE induced phototoxicity and efficiently killed LNCaP cells at low ClAlPc-NC and ClAlPc-NE concentrations (0.3μgmL(-1)) as well as under low light doses of 4Jcm(-2) and 7Jcm(-2), respectively, upon PDT with a 670-nm diode laser line...
March 21, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28349897/3d-printing-scaffold-coupled-with-low-level-light-therapy-for-neural-tissue-regeneration
#12
Wei Zhu, Jonathan K George, Volker J Sorger, Lijie Grace Zhang
3D printing has shown promise for neural regeneration by providing customized nerve scaffolds to structurally support and bridge the defect gap as well as deliver cells or various bioactive substances. Low-level light therapy (LLLT) exhibits positive effects on rehabiliation of degenerative nerves and neural disorders. With this in mind, we postulate that 3D printed neural scaffold coupling with LLLT will generate a new strategy to repair neural degeneration. To achieve this goal, we applied red laser light to stimualte neural stem cells on 3D printed scaffolds and investigated the subsequent cell response with respect to cell proliferation and differentiation...
April 12, 2017: Biofabrication
https://www.readbyqxmd.com/read/28345122/effect-of-laser-on-pain-relief-and-wound-healing-of-recurrent-aphthous-stomatitis-a-systematic-review
#13
REVIEW
Valerie G A Suter, Sophia Sjölund, Michael M Bornstein
The aim of this systematic review was to assess a potential benefit of laser use in the treatment of recurrent aphthous stomatitis (RAS). The primary outcome variables were pain relief, duration of wound healing and reduction in episode frequency. A PICO approach was used as a search strategy in Medline, Embase and Cochrane databases. After scanning and excluding titles, abstracts and full texts, 11 studies (ten RCTs and one non-randomised controlled trial) were included. Study selection and data extraction was done by two observers...
March 27, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28342007/the-effect-of-led-on-blood-microcirculation-during-chronic-wound-healing-in-diabetic-and-non-diabetic-patients-a-prospective-double-blind-randomized-study
#14
Igor Frangez, Ksenija Cankar, Helena Ban Frangez, Dragica Maja Smrke
Chronic wounds, especially in diabetic patients, represent a challenging health issue. Since standard treatment protocols often do not provide satisfactory results, additional treatment methods-like phototherapy using low-level light therapy-are being investigated. The aim of our study was to evaluate the effect of phototherapy with light-emitting diodes on chronic wound treatment in diabetic and non-diabetic patients. Since a sufficient blood supply is mandatory for wound healing, the evaluation of microcirculation in the healthy skin at a wound's edge was the main outcome measure...
March 25, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28337885/role-of-diode-lasers-in-oro-facial-pain-management
#15
F Javed, S V Kellesarian, G E Romanos
With the increasing use of low level laser therapy (LLLT) in clinical dentistry, the aim of the present study was to assess the effectiveness of diode lasers in the management of orofacial pain. Indexed databases were searched without language and time restrictions up to and including July 2016 using different combinations of the following key words: oral, low level laser therapy, dental, pain, diode lasers, discomfort and analgesia. From the literature reviewed it is evident that LLLT is effective compared to traditional procedures in the management of oro-facial pain associated to soft tissue and hard tissue conditions such as premalignant lesions, gingival conditions and dental extractions...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337884/neurochemical-effects-of-photobiostimulation-in-the-trigeminal-ganglion-after-inferior-alveolar-nerve-injury
#16
D O Martins, F M Santos, L R G Britto, J B D Lemos, M Chacur
Orofacial pain is associated with peripheral and central sensitization of trigeminal nociceptive neurons. Nerve injury results in release of chemical mediators that contribute to persistent pain conditions. The activation of the transient receptor potential vanilloid 1 (TRPV1), promotes release of calcitonin gene-related peptide (CGRP) and substance P (SP) from trigeminal nerve terminals. CGRP and SP contribute to the development of peripheral hyperalgesia. The expression of SP and CGRP by primary afferent neurons is rapidly increased in response to peripheral inflammation...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337563/role-of-low-level-laser-therapy-added-to-facial-expression-exercises-in-patients-with-idiopathic-facial-bell-s-palsy
#17
Banu Ordahan, Ali Yavuz Karahan
The aim of the present study was to investigate the efficacy of low-level laser therapy in conjunction with conventional facial exercise treatment on functional outcomes during the early recovery period in patients with facial paralysis. Forty-six patients (mean age 41 ± 9.7 years; 40 women and 6 men) were randomized into two groups. Patients in the first group received low-level laser treatment as well as facial exercise treatment, while patients in the second group participated in facial exercise intervention alone...
May 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28332131/biostimulation-with-diode-laser-positively-regulates-cementoblast-functions-in-vitro
#18
Serife Buket Bozkurt, Erdogan E Hakki, Seyit Ali Kayis, Niyazi Dundar, Sema S Hakki
The aim of this study was to evaluate the effects of diode laser biostimulation on cementoblasts (OCCM.30). A total of 40 root plates were obtained from healthy third molar teeth and assigned to the following two groups: (1) control group and (2) laser-treated group. Root plates were placed into the cell culture inserts, and OCCM.30 cells were seeded onto root plates. Cells were irradiated with a low level of diode laser (power: 0.3 W in continuous wave, 60 s/cm(2)). Proliferation and mineralized tissue-associated gene's and BMP's messenger RNA (mRNA) expressions of cementoblasts were evaluated...
March 22, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28328705/novel-approach-to-treating-androgenetic-alopecia-in-females-with-photobiomodulation-low-level-laser-therapy
#19
Shelly Friedman, Patricia Schnoor
BACKGROUND: Photobiomodulation, also referred to as low-level laser therapy (LLLT), has been studied and used for (among other diseases) the promotion of hair regrowth. OBJECTIVE/MATERIALS AND METHODS/RESULTS: A clinical study was developed to define the physiologic effects that occur when the human hair follicle and surrounding tissue structures are exposed to laser light using a novel device that is fitted with an array of laser diode sources operating at 650 nm and placed inside a sports cap to promote discretion while in use...
March 21, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28324452/a-review-of-ranibizumab-for-the-treatment-of-diabetic-retinopathy
#20
REVIEW
Michael W Stewart
INTRODUCTION: Laser photocoagulation has been the standard treatment for diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) for several decades. The discovery of vascular endothelial growth factor (VEGF) and the subsequent determination of its critical role in the development DME and PDR has led to the development of VEGF inhibitory drugs. Ranibizumab was the first anti-VEGF drug approved for the treatment of both DME and diabetic retinopathy in eyes with DME. METHODS: Medline searches with the keywords "ranibizumab," "diabetic macular edema," and "proliferative diabetic retinopathy" were performed to identify pertinent pre-clinical studies and clinical trials...
March 21, 2017: Ophthalmology and Therapy
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