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https://www.readbyqxmd.com/read/29754065/role-preferences-of-patients-with-alcohol-use-disorders
#1
Anke Friedrichs, Anna Silkens, Jens Reimer, Ludwig Kraus, Norbert Scherbaum, Daniela Piontek, Jeanette Röhrig, Jochen Hempleman, Martin Härter, Angela Buchholz
AIMS: Shared decision making (SDM) is increasingly demanded in medical decision making. SDM acknowledges patients' role preferences in decision making processes. There has been limited research on SDM and role preferences in substance use disorders; results are promising. Aim of this study was to investigate role preferences of patients with alcohol use disorders (AUD), and to identify predictors of these preferences. METHOD: Cross-sectional data collected from June 2013 to May 2014 in four detoxification wards in Germany during a randomised controlled trial (RCT, Registration Code 01GY1114) was analysed...
May 4, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29707965/an-enriched-environment-ameliorates-oxidative-stress-and-olfactory-dysfunction-in-parkinson-s-disease-with-%C3%AE-synucleinopathy
#2
Soohyun Wi, Jang Woo Lee, MinGi Kim, Chang-Hwan Park, Sung-Rae Cho
Parkinson's disease (PD) features nonmotor symptoms such as olfactory dysfunction referred to as hyposmia, an initial sign of disease progression. Metabolic dysfunction can contribute to neurodegenerative diseases, and various xenobiotics and endogenous compounds are also involved in the pathogenesis of PD. Although aerobic exercise was found to induce preservation or improvement in olfactory function in PD patients in a recent study, the exact underlying mechanism for this effect is not clear. We aimed to investigate the influence of an enriched environment (EE) on olfactory dysfunction especially via metabolic pathways related to detoxification enzymes...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29704316/genome-wide-and-digital-polymerase-chain-reaction-epigenetic-assessments-of-alcohol-consumption
#3
Robert Philibert, Meesha Dogan, Amanda Noel, Shelly Miller, Brianna Krukow, Emma Papworth, Joseph Cowley, April Knudsen, Steven R H Beach, Donald Black
The lack of readily employable biomarkers of alcohol consumption is a problem for clinicians and researchers. In 2014, we published a preliminary DNA methylation signature of heavy alcohol consumption that remits as a function of abstinence. Herein, we present new genome-wide methylation findings from a cohort of additional subjects and a meta-analysis of the data. Using DNA from 47 consecutive heavy drinkers admitted for alcohol detoxification in the context of alcohol treatment and 47 abstinent controls, we replicate the 2014 results and show that 21,221 CpG residues are differentially methylated in active heavy drinkers...
April 28, 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29680676/loaded-gun-involvement-among-opioid-users
#4
Michael D Stein, Shannon R Kenney, Bradley J Anderson, Genie L Bailey
INTRODUCTION: Despite ample research examining how alcohol use relates to gun involvement, little is known about the relationship between opioids and gun involvement. In the current study, we examined correlates of gun possession, accessibility, and related behaviors in an opioid dependent sample. METHODS: Between October 2016 and April 2017, we surveyed persons entering a brief, inpatient opioid detoxification (n = 386) and 51 contemporaneous persons seeking alcohol detoxification at the same facility in Massachusetts and recorded their lifetime experiences with gun involvement...
April 16, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29676057/the-effects-of-acute-alcohol-withdrawal-on-sleep
#5
Christopher J Hodges, Rowan P Ogeil, Dan I Lubman
OBJECTIVES: Although sleep disturbances are prominent during alcohol withdrawal, less is known about the specific components of sleep that are disturbed prior to and during acute detoxification. This study aimed to determine whether specific sleep components are affected prior to and during acute detoxification and their relationship to psychological distress. METHODS: Twenty-nine participants were recruited from a residential detoxification service in Melbourne, Australia, and completed both subjective methods of sleep and distress, in addition to wearing an actigraphy device...
April 20, 2018: Human Psychopharmacology
https://www.readbyqxmd.com/read/29674602/neuropsychological-performance-in-alcohol-dependent-patients-a-one-year-longitudinal-study
#6
Lucia Ioime, Riccardo Guglielmo, Giuseppe Fertonani Affini, Marianna Quatrale, Giovanni Martinotti, Antonino Callea, Evelina Savi, Luigi Janiri
Objective: Despite several studies that have highlighted the harmful effects of alcohol consumption on cognitive functions it remains unclear whether certain brain areas are more sensitive than others are or whether alcohol causes widespread cognitive deficit. Moreover, the role of continued abstinence has yet to be clarified regarding the quality of recovery on the different cognitive domains. The aim of this 1-year longitudinal study was to evaluate the recovery of cognitive deficits in the medium (6 months) and long term (12 months) after the interruption of drinking...
April 20, 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29671087/severe-adverse-reactions-following-ketoconazole-fluconazole-and-environmental-exposures-a-case-report
#7
Allan Lieberman, Luke Curtis
In this case report, we describe a 66-year-old man who developed multiple adverse reactions beginning at age 56 after exposure to several azole antifungal drugs including ketoconazole and fluconazole. He also had a history of more than 40 years exposure to chemicals including pesticides, wood preservatives, fertilizers, and welding chemicals. His reactions involved dehydration (requiring several liters of intravenous fluids in less than an hour to alleviate this condition), angioedema, nausea, tinnitus, hypotension, and difficulty breathing...
April 18, 2018: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29668421/factors-associated-with-unplanned-early-discharges-from-a-dual-diagnosis-inpatient-detoxification-unit-in-israel
#8
Menachem M Sofer, Alexander Kaptsan, Jonathan Anson
OBJECTIVES: Currently, Israel has a single governmental inpatient dual diagnosis detoxification unit. We provide a cross-section of patient profiles in this unit, as well as explore possible associations between clinical/demographic factors, and the unplanned early discharge of patients from the unit, aiming at improving rehabilitation success rates. METHODS: In this retrospective study, medical records of all patients admitted to the unit between January 1st 2012 and July 1st 2013 were examined (N = 323)...
April 18, 2018: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/29605483/severe-opioid-withdrawal-precipitated-by-vivitrol%C3%A2
#9
R S Wightman, L S Nelson, J D Lee, L M Fox, S W Smith
The risk of severe precipitated opioid withdrawal (POW) is amplified when precipitated by a long-acting opioid antagonist. IM extended release naltrexone (XRNTX;Vivitrol®) is an FDA approved therapy to prevent relapse of opioid and alcohol abuse. Two cases of precipitated opioid withdrawal from XRNTX are presented that illustrate different patient reactions to POW. A 56-year-old woman developed a hypertensive emergency and required continuous intravenous vasodilator, clonidine, and intensive care monitoring after re-initiation of XRNTX following opioid relapse...
March 21, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29604618/an-open-prospective-pilot-study-of-a-herbal-combination-relief-as-a-supportive-dietetic-measure-during-alcohol-withdrawal
#10
Kenza Mansoor, Fadi Qadan, Andreas Hinum, Caroline Schneider, Klaus Hechenbichler, Mathias Schmidt, Georg Linsinger, Khalid Matalka
OBJECTIVE: A herbal combination (saffron extract, passion flower herb extract, cocoa seed extract, radish extract and black cumin extract) called "Relief" was designed as a supportive therapy of alcohol withdrawal syndrome (AWS). This combination was based on the scientific evidence of each constituent effect on AWS-like symptoms. In addition, our preclinical studies have shown the effectiveness of Relief on AWS detoxification. The rationale of the study was to document whether the oral intake of the designed content of Relief could have a positive effect on the course of alcohol detoxification by reducing some of the AWS in hospitalized patients...
March 1, 2018: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29589877/an-observational-study-of-benzodiazepine-prescription-during-inpatient-alcohol-detoxification-for-patients-with-versus-without-chronic-pretreatment-with-high-dosage-baclofen
#11
EDITORIAL
https://www.readbyqxmd.com/read/29582627/adh1b-aldh2-gstm1-and-gstt1-gene-polymorphic-frequencies-among-alcoholics-and-controls-in-the-arcadian-population-of-central-india
#12
Abdul Anvesh Mansoori, Subodh Kumar Jain
Background: Epidemiological research has highlighted the global burden of primary liver cancer cases due to alcohol consumption, even in a low consumption country like India. Alcohol detoxification is governed by ADH1B, ALDH2, GSTM1 and GSTT1 genes that encode functional enzymes which are coordinated with each other to remove highly toxic metabolites i.e. acetaldehyde as well as reactive oxygen species generated through detoxification processes. Some communities in the population appears to be at greater risk for development of the liver cancer due to genetic predispositions...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29560777/outreach-visits-improve-referral-of-alcohol-dependent-patients-from-psychiatric-hospital-to-continued-care-a-randomized-trial
#13
Anette Søgaard Nielsen, Bent Nielsen
PURPOSE: Many patients with alcohol use disorder (AUD) fail to initiate outpatient treatment after being discharged from inpatient detoxification. The aim of the present study was to investigate the effect of outreach visits (OV) on subsequent attendance in outpatient AUD treatment. METHODS: Patients admitted to a detoxification unit at a mental health hospital were randomized to either referral as usual (TAU) or OV. OV involved a nurse from the outpatient clinic meeting the patients at the hospital and advising them about outpatient treatment, presenting an 'attendance contract' and offering a first appointment...
March 21, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29506687/aldh2-protects-against-alcoholic-cardiomyopathy-through-a-mechanism-involving-the-p38-mapk-creb-pathway-and-local-renin-angiotensin-system-inhibition-in-cardiomyocytes
#14
Baoshan Liu, Rui Zhang, Shujian Wei, Qiuhuan Yuan, Mengyang Xue, Panpan Hao, Feng Xu, Jiali Wang, Yuguo Chen
BACKGROUND: Angiotensin II (Ang II) in the local cardiac renin-angiotensin system (RAS) is closely associated with alcoholic cardiomyopathy (ACM). Inhibition of local cardiac RAS has great significance in the treatment of ACM. Although aldehyde dehydrogenase 2 (ALDH2) has been demonstrated to protect against ACM through detoxification of aldehydes, the precise mechanisms are largely unknown. In the present study, we determined whether ALDH2 improved cardiac damage by inhibiting the local RAS in ACM and investigated the related regulatory mechanisms...
April 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29470469/acceptability-of-electronic-cigarettes-as-an-option-to-replace-tobacco-smoking-for-alcoholics-admitted-to-hospital-for-detoxification
#15
Penelope Truman, Moira Gilmour, Geoffrey Robinson
AIM: A feasibility/acceptability trial was undertaken at Ward 5, Kenepuru Hospital, Porirua, to ascertain whether electronic cigarettes (e-cigarettes) were a useful option to replace or reduce smoking in the detoxification ward. METHODS: Two groups of patients were studied. Tobacco use and dependency data were collected for each. The first group was surveyed on the usefulness of standard nicotine replacement therapy (NRT). The second group were offered e-cigarettes with the option of standard NRT as well...
February 23, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29434386/evaluation-of-the-incidence-of-ibuprofen-administration-in-alcohol-and-opioid-detoxification-patients-with-concomitant-thrombocytopenia
#16
Sheheryar Muhammad, John R Tomko, Laura M Wilson
Purpose: The purpose of this study was to determine the incidence of ibuprofen administration in patients who are undergoing alcohol and opioid detoxification, and have concomitant alcohol-related thrombocytopenia. Methods: This was a single-center, cross-sectional, prospective, observational study. A daily manual review of electronic health records was conducted for patients admitted to the detoxification unit of the hospital. Patients who (1) were of age 18 years or more, (2) were ordered both alcohol and opioid detoxification protocols, and (3) had a platelet count of less than 150 000/µL were included in the study...
February 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29431026/the-potential-of-aldehyde-dehydrogenase-2-as-a-therapeutic-target-in-cardiovascular-disease
#17
Thomas Münzel, Andreas Daiber
Mitochondrial aldehyde dehydrogenase (ALDH-2) plays a major role in the ethanol detoxification pathway by removing acetaldehyde. Therefore, ALDH-2 inhibitors such as disulfiram represent the first therapeutic targeting of ALDH-2 for alcoholism therapy. Areas covered: Recently, ALDH-2 was identified as an essential bioactivating enzyme of the anti-ischemic organic nitrate nitroglycerin, bringing ALDH-2 again into the focus of clinical interest. Mechanistic studies on the nitroglycerin bioactivation process revealed that during bioconversion of nitroglycerin and in the presence of reactive oxygen and nitrogen species the active site thiols of ALDH-2 are oxidized and the enzyme activity is lost...
March 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29425791/prescription-drug-use-and-misuse-in-a-cohort-of-people-who-inject-drugs-pwid-in-baltimore
#18
Alexia Anagnostopoulos, Alison G Abraham, Becky L Genberg, Gregory D Kirk, Shruti H Mehta
BACKGROUND: Prescription drug misuse and its consequences (e.g., overdose) are a major public health concern. While national focus has been on opioids, misuse of sedatives/tranquilizers also occurs. Here we describe the use, correlates, and sources of prescription drugs in a community-based cohort of people who inject drugs (PWID). METHODS: We included participants of the AIDS Linked to the IntraVenous Experience (ALIVE) study in follow-up in 2014. We defined prescription drug use as use of opioids or sedatives/tranquilizers considering both medical "prescribed by a doctor" and non-medical sources "obtained from the street/friend/relative...
June 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29415850/patterns-of-co-occurring-addictions-posttraumatic-stress-disorder-and-major-depressive-disorder-in-detoxification-treatment-seekers-implications-for-improving-detoxification-treatment-outcomes
#19
RaeAnn E Anderson, Bryce Hruska, Alec P Boros, Christopher J Richardson, Douglas L Delahanty
BACKGROUND AND OBJECTIVES: Poly-substance use and psychiatric comorbidity are common among individuals receiving substance detoxification services. Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are the most common co-occurring psychiatric disorders with substance use disorder (SUD). Current treatment favors a one-size-fits-all approach to treating addiction focusing on one substance or one comorbidity. Research examining patterns of substance use and comorbidities can inform efforts to effectively identify and differentially treat individuals with co-occurring conditions...
March 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29409117/comparison-of-secretome-profile-of-pathogenic-and-non-pathogenic-entamoeba-histolytica
#20
Chun-Seob Ahn, Jeong-Geun Kim, Myeong Heon Shin, Young Ah Lee, Yoon Kong
The obligatory intracellular protozoan parasite Entamoeba histolytica causes amebic dysentery and liver abscess. E. histolytica adheres to the host tissues in a contact-dependent manner. E. histolytica excretory-secretory products (ESP) might play critical roles during invasion. We comparatively analyzed the secretome profile of E. histolytica pathogenic HM-1:IMSS and non-pathogenic Rahman strains. The two ESP revealed similar but distinct spotting patterns. In both ESP, alcohol dehydrogenase, enolase 1, and transketolase, which control classical carbohydrate metabolism and other moonlighting effects, constituted the most abundant fractions...
April 2018: Proteomics
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