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https://www.readbyqxmd.com/read/29026811/the-use-of-platelet-rich-plasma-for-storage-of-surplus-harvested-skin-grafts
#1
Ilknur Keskin, Nilufer Ayturk, Mustafa Sutcu, Mustafa Keskin, Tangul Mudok
BACKGROUND: There is a need for improved methods and storage media to sustain the tissue viability of autologous skin grafts. OBJECTIVE: To compare histological changes in human skin grafts stored in platelet-rich plasma (PRP) with those of grafts stored in saline. METHODS: Eight circular, 3-mm full-thickness skin graft samples were harvested from the abdominal skin of each of 5 patients scheduled to undergo an abdominoplasty procedure. Four of these graft samples were stored in saline, and the other 4 were stored in saline mixed with PRP prepared from the patient's own venous blood...
February 2017: Plastic Surgery
https://www.readbyqxmd.com/read/29026341/benefits-of-different-postoperative-treatments-in-patients-undergoing-knee-arthroscopic-debridement
#2
Cesáreo Trueba Vasavilbaso, Carlos David Rosas Bello, Erla Medina López, Maria Pilar Coronel Granado, José Mario Navarrete Álvarez, Cesáreo Angel Trueba Davalillo, Félix Isaac Gil Orbezo
PURPOSE: To assess the effectiveness of viscosupplementation or platelet-rich plasma (PRP), compared to standard care, for pain relief after knee arthroscopic debridement in patients with meniscal pathology and osteoarthritis (OA), under normal clinical practice conditions. PATIENTS AND METHODS: We conducted a prospective, randomized, evaluator-blind, pilot study. After arthroscopy, patients were randomized to receive 1) five injections of HA1 (Suprahyal(®)/Adant(®)); 2) four injections of HA2 (Orthovisc(®)); 3) three injections of HA3 (Synvisc(®)); 4) a single injection of PRP (GPS™ II); or 5) standard care (control)...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29023179/effect-of-platelet-rich-plasma-on-patients-after-blepharoplasty-surgery
#3
Fidelina Parra, David Enrique Morales-Rome, Rafael Campos-Rodríguez, Teresita Rocío Cruz-Hernández, Maria Elisa Drago-Serrano
AIM: To evaluate the effect of platelet-rich plasma (PRP) treatment on patients after blepharoplasty surgery. MATERIALS AND METHODS: After undergoing blepharoplasty, 20 patients were randomly divided into two groups (n = 10 each). One was treated with autologous PRP and the other was not given any post-surgery treatment (basal group). Autologous PRP application was performed intradermically 24 h, 1 month, and 2 months post-surgery, and the outcome of the applications was assessed 1, 2, and 3 months post-surgery...
October 12, 2017: Orbit
https://www.readbyqxmd.com/read/29022492/platelet-aggregation-impacts-thrombin-generation-assessed-by-calibrated-automated-thrombography
#4
Mélusine Didelot, Clémence Docq, Denis Wahl, Patrick Lacolley, Véronique Regnault, Jérémy Lagrange
A calibrated automated thrombogram (CAT) is performed usually with human platelet-free plasma (PFP) but may be more relevant with platelet-rich plasma (PRP). In this case, platelets are not stimulated by subendothelial molecules like collagen. Our aim was to assess the consequence of strong (collagen) or weak (ADP) induction of platelet release and aggregation on thrombin generation. Platelet aggregation in PRP was triggered with 10 µg/mL collagen or 10 µM ADP using a lumi-aggregometer. Thrombin generation curves were monitored by CAT in different conditions: PRP, PRP with activated platelets (actPRP), aggregated PRP (agPRP), aggregated platelets resuspended in autologous PFP (resPRP), PFP and PFP obtained after aggregation (agPFP)...
October 12, 2017: Platelets
https://www.readbyqxmd.com/read/29022296/efficacy-and-safety-of-intracameral-bevacizumab-for-treatment-of-neovascular-glaucoma
#5
Jun Young Ha, Mi Sun Sung, Sang Woo Park
PURPOSE: To evaluate the long-term efficacy and safety of intracameral bevacizumab in patients with neovascular glaucoma. METHODS: This retrospective study included 26 eyes of 26 neovascular glaucoma patients who received intracameral bevacizumab injection between January 2013 and May 2015, and were followed-up for at least 1 year. All patients were treated with topical and/or systemic intraocular pressure (IOP)-lowering medications, intracameral bevacizumab, and panretinal photocoagulation (PRP)...
August 26, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29020977/platelet-rich-plasma-stimulates-angiogenesis-in-mice-which-may-promote-hair-growth
#6
Hanxiao Cheng, Jufang Zhang, Jinsheng Li, Ming Jia, Yuyan Wang, Haiyan Shen
BACKGROUND: Platelet-rich plasma (PRP) is an autologous concentration of human platelets in plasma. In this paper, we aimed to investigate the effect of PRP on hair growth. METHODS: Platelet-rich plasma and platelet-poor plasma were prepared by sterile centrifugation and injected into shaved dorsal skin of mice (n = 10). Saline injection was used in the control group. The length of randomly plucked hairs was measured at 8, 13, 18 days after PRP injection. Histological examination was preformed to observe the histologic changes of skins...
October 11, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29019941/the-contribution-of-adipose-tissue-derived-mesenchymal-stem-cells-and-platelet-rich-plasma-to-the-treatment-of-chronic-equine-laminitis-a-proof-of-concept
#7
Mario Angelone, Virna Conti, Cristiano Biacca, Beatrice Battaglia, Laura Pecorari, Francesco Piana, Giacomo Gnudi, Fabio Leonardi, Roberto Ramoni, Giuseppina Basini, Silvia Dotti, Sabrina Renzi, Maura Ferrari, Stefano Grolli
Laminitis, a highly debilitating disease of the foot in ungulates, is characterized by pathological changes of the complex lamellar structures that maintain the appendicular skeleton within the hoof. Laminitis is a multifactorial disease that involves perturbation of the vascular, hematological, and inflammatory homeostasis of the foot. Interestingly, the pathogenesis of the disease resembles what is observed in metabolic syndromes and sepsis-induced organ failure in humans and animals. We hypothesized that local administration of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) might contribute to establishing an anti-inflammatory and pro-angiogenic environment, and could stimulate the injured tissue in order to restore its functional integrity...
October 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29019860/the-addition-of-prp-to-facial-lipofilling-a-double-blind-placebo-controlled-randomized-trial
#8
J C N Willemsen, J Van Dongen, M Spiekman, K M Vermeulen, M C Harmsen, B van der Lei, H P J D Stevens
BACKGROUND: Lipofilling is a treatment modality to restore tissue volume, but may also rejuvenate the aging skin. Platelet-rich plasma has been reported to augment the efficacy of lipofilling, both on graft take and rejuvenation by altering the ADSC. Authors hypothesized that PRP addition would increase the rejuvenating effect while shortening recovery time. METHODS: The study conducted was a single-centre, double blinded, placebo-controlled randomized trial (2012-2015)...
October 10, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29017702/collaborative-study-on-saccharide-quantification-of-the-haemophilus-influenzae-type-b-component-in-liquid-vaccine-presentations
#9
U Rosskopf, A Daas, E Terao, C von Hunolstein
Before release onto the market, it must be demonstrated that the total and free polysaccharide (poly ribosyl-ribitol-phosphate, PRP) content of Haemophilus influenzae type b (Hib) vaccine complies with requirements. However, manufacturers use different methods to assay PRP content: a national control laboratory must establish and validate the relevant manufacturer methodology before using it to determine PRP content. An international study was organised by the World Health Organization (WHO), in collaboration with the Biological Standardisation Programme (BSP) of the Council of Europe/European Directorate for the Quality of Medicines & HealthCare (EDQM) and of the European Union Commission, to verify the suitability of a single method for determining PRP content in liquid pentavalent vaccines (DTwP-HepB-Hib) containing a whole-cell pertussis component...
2017: Pharmeuropa Bio & Scientific Notes
https://www.readbyqxmd.com/read/28994814/real-time-quaking-induced-conversion-assay-for-detection-of-cwd-prions-in-fecal-material
#10
Yo Ching Cheng, Samia Hannaoui, Theodore Ralph John, Sandor Dudas, Stefanie Czub, Sabine Gilch
The RT-QuIC technique is a sensitive in vitro cell-free prion amplification assay based mainly on the seeded misfolding and aggregation of recombinant prion protein (PrP) substrate using prion seeds as a template for the conversion. RT-QuIC is a novel high-throughput technique which is analogous to real-time polymerase chain reaction (PCR). Detection of amyloid fibril growth is based on the dye Thioflavin T, which fluoresces upon specific interaction with ᵦ-sheet rich proteins. Thus, amyloid formation can be detected in real time...
September 29, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28993845/-new-experimental-strategies-in-cartilage-surgery
#11
REVIEW
L Rackwitz, J C Reichert, O Pullig, U Nöth
BACKGROUND: Cell and growth factor based strategies bear great potential to support the healing processes in cartilage repair and the therapy of osteoarthritic joints. OBJECTIVES: The following review provides an overview of novel experimental strategies for the therapy of focal cartilage defects and osteoarthritis, with emphasis on cell and growth factor based approaches. MATERIALS AND METHODS: The authors summarize their own data regarding the intraarticular injection of stem cells to treat osteoarthritis of the knee and provide a synopsis of the available literature discussing the most significant publications...
October 9, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28991280/plasma-rico-en-plaquetas-y-su-efecto-en-la-regeneraci%C3%A3-n-%C3%A3-sea-en-fracturas-mandibulares-ensayo-cl%C3%A3-nico-controlado
#12
Guadalupe Castillo-Cardiel, Víctor Manuel Medina-Quintana, Mario Lomelí-Enríquez, Fabiola Medrano-Muñoz, Celia Guerrero-Velázquez, Carmen Karina Contreras-López, Clotilde Fuentes-Orozco, Leire Irusteta-Jiménez, Luis Rodrigo Michel-Espinoza, Alejandro González-Ojeda
Antecedentes: Actualmente existe interés en el desarrollo de aplicaciones clínicas del plasma rico en plaquetas (PRP) para mejorar la regeneración ósea (RO). Objetivo: Evaluar la RO en fracturas mandibulares con la aplicación de PRP. Métodos: Ensayo clínico controlado. Se incluyeron 20 pacientes con fractura de ángulo mandibular. El grupo de estudio (n = 10) se sometió a reducción de la fractura, fijación interna y aplicación de PRP, y el grupo control (n = 10) al mismo procedimiento sin administración de plasma...
2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28990574/an-evidence-based-evaluation-on-the-use-of-platelet-rich-plasma-in-orthopedics-a-review-of-the-literature
#13
Nasir Hussain, Herman Johal, Mohit Bhandari
Within orthopedics, the use of platelet-rich plasma (PRP) has been rapidly increasing in popularity, however, its true effectiveness has yet to be fully established. Several studies find that injecting PRP to the site of injury does not provide any significant benefit with respect to clinical outcomes; however, many others report the contrary. Due to the conflicting evidence and multiple meta-analyses conducted on the topic, a literature review of high-quality evidence on the use of PRP for common orthopaedic conditions was performed...
2017: SICOT-J
https://www.readbyqxmd.com/read/28989689/semisynthetic-prion-protein-prp-variants-carrying-glycan-mimics-at-position-181-and-197-do-not-form-fibrils
#14
Can Araman, Robert E Thompson, Siyao Wang, Stefanie Hackl, Richard J Payne, Christian F W Becker
The prion protein (PrP) is an N-glycosylated protein attached to the outer leaflet of eukaryotic cell membranes via a glycosylphosphatidylinositol (GPI) anchor. Different prion strains have distinct glycosylation patterns and the extent of glycosylation of potentially pathogenic misfolded prion protein (PrP(Sc)) has a major impact on several prion-related diseases (transmissible spongiform encephalopathies, TSEs). Based on these findings it is hypothesized that posttranslational modifications (PTMs) of PrP influence conversion of cellular prion protein (PrP(C)) into PrP(Sc) and, as such, modified PrP variants are critical tools needed to investigate the impact of PTMs on the pathogenesis of TSEs...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28986682/efficacy-and-safety-of-pleurodesis-using-platelet-rich-plasma-and-fibrin-glue-in-management-of-postoperative-chylothorax-after-esophagectomy
#15
Daryoush Hamidi Alamdari, Mehdi Asadi, Ahmad Nejad Rahim, Ghodratollah Maddah, Shahariar Azizi, Soudabeh Shahidsales, Mostafa Mehrabibahar
INTRODUCTION: Chylothorax is by definition a collection of lymphatic fluids in the pleural cavity because of leakage from main thoracic duct or its tributaries. It is an uncommon but serious postoperative complication in esophageal cancer patients. There is no standard therapeutic algorithm for chylothorax because no prospective or randomized trials have yet been performed to evaluate the available treatment options. The aim of this study was to evaluate the efficacy of pleurodesis with a combination of platelet-rich plasma (PRP) and fibrin glue to the treatment of chylothorax after trans-hiatal esophagectomy...
October 6, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28981200/soluble-fibrin-causes-an-acquired-platelet-glycoprotein-vi-signaling-defect-implications-for-coagulopathy
#16
Mei Yan Lee, Christopher C Verni, Bradley A Herbig, Scott L Diamond
BACKGROUND: In coagulopathic blood, circulating thrombin may drive platelet dysfunction. METHODS/RESULTS: Using calcium dye-loaded platelets, the effect of thrombin exposure and soluble fibrin generation on subsequent platelet GPVI function was investigated. Exposure of apixaban-treated platelet-rich plasma (12% PRP) to thrombin (1-10 nM), but not ADP or thromboxane mimetic U46619 exposure, dramatically blocked subsequent GPVI activation by convulxin, collagen-related peptide, or fibrillar collagen...
October 5, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28980027/-insertional-achilles-tendinopathy-differentiated-diagnostics-and-therapy
#17
REVIEW
S F Baumbach, M Braunstein, M G Mack, F Maßen, W Böcker, S Polzer, H Polzer
Achilles tendinopathy at the calcaneal insertion is classified into insertional tendinopathy, retrocalcaneal and superficial bursitis. The aim of this study was to present the current evidence on conservative and surgical treatment of insertional tendinopathy of the Achilles tendon. Conservative first-line therapy includes reduction of activity levels, administration of non-steroidal anti-inflammatory drugs (NSAID), adaptation of footwear, heel wedges and orthoses or immobilization. In addition, further conservative therapy options are also available...
October 4, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28978705/an-in-vitro-approach-to-identify-the-key-amino-acids-in-the-low-susceptibility-of-rabbit-prp-to-misfolding
#18
Hasier Eraña, Natalia Fernández-Borges, Saioa R Elezgarai, Chafik Harrathi, Jorge M Charco, Francesca Chianini, Mark P Dagleish, Gabriel Ortega, Óscar Millet, Joaquín Castilla
Prion diseases or transmissible spongiform encephalopathies (TSEs) are a group of rare progressive neurodegenerative disorders caused by an abnormally folded prion protein (PrP(Sc)). This is capable of transforming the normal cellular prion protein (PrP(C)) in to new infectious PrP(Sc) Interspecies prion transmissibility studies performed by experimental challenge and the outbreak of bovine spongiform encephalopathy that occurred in the late 1980s-1990's showed that while some species were readily susceptible to TSEs (sheep, mice and cats), others were apparently resistant (rabbits, dogs and horses) when exposed to the same agent...
October 4, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28978309/soluble-polymorphic-bank-vole-prion-proteins-induced-by-co-expression-of-quiescin-sulfhydryl-oxidase-in-e-coli-and-their-aggregation-behaviors
#19
Romany Abskharon, Johnny Dang, Ameer Elfarash, Zerui Wang, Pingping Shen, Lewis S Zou, Sedky Hassan, Fei Wang, Hisashi Fujioka, Jan Steyaert, Mentor Mulaj, Witold K Surewicz, Joaquín Castilla, Alexandre Wohlkonig, Wen-Quan Zou
BACKGROUND: The infectious prion protein (PrP(Sc) or prion) is derived from its cellular form (PrP(C)) through a conformational transition in animal and human prion diseases. Studies have shown that the interspecies conversion of PrP(C) to PrP(Sc) is largely swayed by species barriers, which is mainly deciphered by the sequence and conformation of the proteins among species. However, the bank vole PrP(C) (BVPrP) is highly susceptible to PrP(Sc) from different species. Transgenic mice expressing BVPrP with the polymorphic isoleucine (109I) but methionine (109M) at residue 109 spontaneously develop prion disease...
October 4, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28977946/combination-of-bone-marrow-mesenchymal-stem-cells-sheet-and-platelet-rich-plasma-for-posterolateral-lumbar-fusion
#20
Zunpeng Liu, Yue Zhu, Rui Ge, Jiajun Zhu, Xiaoning He, Xue Yuan, Xinchun Liu
Bone tissue engineering provides a substitute for bone transplantation in spinal fusion. This study examined if combined bone marrow-derived mesenchymal stem cells (BMSCs) sheet with platelet-rich plasma (PRP) could promote bone regeneration in a rabbit posterolateral spinal fusion model. BMSCs was isolated and confirmed by Flow cytometric analysis and immunofluorescence staining. The morphology of BMSCs was examined by Hematoxylin and Eosin staining, scanning and transmission electron microscopy. BMSCs were cultured in induction medium or control medium...
September 22, 2017: Oncotarget
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