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https://www.readbyqxmd.com/read/29053980/incident-mental-disorders-in-the-aftermath-of-traumatic-events-a-prospective-longitudinal-community-study
#1
Eva Asselmann, Hans-Ulrich Wittchen, Roselind Lieb, Axel Perkonigg, Katja Beesdo-Baum
BACKGROUND: Few strictly prospective-longitudinal community studies examined the role of traumatic events for risk of developing a broad range of incident mental disorders over several years. METHOD: A representative community sample of adolescents and young adults (n = 2797, baseline age 14-24) was prospectively examined in up to three assessment waves over up to 10 years. Traumatic events and DSM-IV mental disorders were assessed at each wave using the DIA-X/M-CIDI...
October 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29053887/low-foxg1-and-high-olig-2-labelling-indices-define-a-prognostically-favorable-subset-in-idh-mutant-gliomas
#2
Sarah Schäfer, Felix Behling, Marco Skardelly, Marilin Koch, Ines Ott, Frank Paulsen, Ghazaleh Tabatabai, Jens Schittenhelm
AIMS: Previous data suggest that expression of transcription factors FoxG1 and Olig-2 can separate hotspot H3F3A-mutant tumors in pediatric glioma. We evaluated their prognostic potential and feasibility for identifying H3F3A-mutant tumors among IDH-mutant/wildtype gliomas. METHODS: Immunohistochemistry of FoxG1/Olig-2 and ATRX in 471 cases of diffuse gliomas and molecular determination of IDH, H3F3A, MGMT and 1p/19 codeletion status. RESULTS: Mean percentage of FoxG1 positive tumor cells increased from 17% in WHO grade II to over 21% in grade III to 37% in grade IV tumors, while mean Olig-2 indices decreased from 29% to 28% to 17% respectively...
October 20, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29053761/the-transcription-factor-prdm16-marks-a-single-retinal-ganglion-cell-subtype-in-the-mouse-retina
#3
Sergio Groman-Lupa, Joseph Adewumi, Ko Uoon Park, Joseph A Brzezinski Iv
Purpose: Retinal ganglion cells (RGC) can be categorized into roughly 30 distinct subtypes. How these subtypes develop is poorly understood, in part because few unique subtype markers have been characterized. We tested whether the Prdm16 transcription factor is expressed by RGCs as a class or within particular ganglion cell subtypes. Methods: Embryonic and mature retinal sections and flatmount preparations were examined by immunohistochemistry for Prdm16 and several other cell type-specific markers...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29053643/genome-wide-identification-and-analysis-of-mapk-and-mapkk-gene-families-in-bread-wheat-triticum-aestivum-l
#4
Haoshuang Zhan, Hong Yue, Xian Zhao, Meng Wang, Weining Song, Xiaojun Nie
The mitogen-activated protein kinase (MAPK) cascade is a universal signal transduction module that plays a vital role in regulating growth and development, as well as environmental stress responses in plants. Wheat is one of the most important crops worldwide. Although the MAPK kinase kinase (MAP3K) family in wheat has been investigated, the MAPK and MAPK kinase (MAP2K) gene families remain unknown at present. Here, 54 MAPK and 18 MAPKK genes were identified in wheat using recent genomic information. Phylogenetic analysis of Triticum aestivum L...
October 20, 2017: Genes
https://www.readbyqxmd.com/read/29053265/step-economical-photoassisted-diversity-oriented-synthesis-sustaining-cascade-photoreactions-in-oxalyl-anilides-to-access-complex-polyheterocyclic-molecular-architectures
#5
Dmitry M Kuznetsov, Andrei G Kutateladze
Atom- and step-economy in photoassisted DOS is achieved with a versatile oxalyl linker offering rapid access to complex alkaloid mimics in very few experimentally simple steps: (i) it allows for fast tethering of the photoactive core to the unsaturated pendants, especially im-portant in the case of (hetero)aromatic amines - essentially a one pot reaction with no isolation of intermediates; (ii) the α-dicarbonyl tether acts as a chromophore enhancer, extending the conjugation chain and facilitating the 'harvest' of the lower energy photons for the primary and secondary photoreactions, (iii) it enhances the quantum yield of intersystem crossing (ISC), i...
October 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29053162/the-role-of-association-of-ions-in-ionic-liquid-molecular-solvent-mixtures-on-metal-extraction
#6
J-M Andanson, N Papaiconomou, P-A Cable, M Traïkia, I Billard, P Husson
Several mixtures of butyl acetate (BA) and an ionic liquid (1-methyl-3-octylpyrrolidinium bis(trifluoromethylsulfonyl)imide, [C1C8Pyrro][NTf2], 1-octyl-pyridinium bis(trifluoromethylsulfonyl)imide, [C8Pyr][NTf2], 1-butyl-3-methyl-imidazolium bis(trifluoromethylsulfonyl)imide, [C1C4Im][NTf2] or 1-octyl-3-methyl-imidazolium bis(trifluoromethylsulfonyl)imide, [C1C8Im][NTf2]) have been characterized by measuring density, viscosity and conductivity, from pure BA to pure ILs at 298.15 K. The ionicity of these mixtures has been determined on the basis of electrical conductivity and NMR spectroscopy...
October 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29053141/loss-of-bim-increases-mitochondrial-oxygen-consumption-and-lipid-oxidation-reduces-adiposity-and-improves-insulin-sensitivity-in-mice
#7
Jibran A Wali, Sandra Galic, Christina Yr Tan, Esteban N Gurzov, Ann E Frazier, Timothy Connor, Jingjing Ge, Evan G Pappas, David Stroud, L Chitra Varanasi, Claudia Selck, Michael T Ryan, David R Thorburn, Bruce E Kemp, Balasubramanian Krishnamurthy, Thomas Wh Kay, Sean L McGee, Helen E Thomas
BCL-2 proteins are known to engage each other to determine the fate of a cell after a death stimulus. However, their evolutionary conservation and the many other reported binding partners suggest an additional function not directly linked to apoptosis regulation. To identify such a function, we studied mice lacking the BH3-only protein BIM. BIM(-/-) cells had a higher mitochondrial oxygen consumption rate that was associated with higher mitochondrial complex IV activity. The consequences of increased oxygen consumption in BIM(-/-) mice were significantly lower body weights, reduced adiposity and lower hepatic lipid content...
October 20, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29053083/surgical-management-of-penetrating-spinal-cord-injury-primarily-due-to-shrapnel-and-its-effect-on-neurological-outcome-a-literature-review-and-meta-analysis
#8
Michael H Lawless, Evan J Lytle, Andrea F McGlynn, John A Engler
OBJECTIVE This study was performed to determine whether decompression of penetrating spinal cord injury (SCI) due to explosive shrapnel leads to greater neurological recovery than conservative management. METHODS In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive literature search using PubMed/MEDLINE, Web of Science, Google Scholar, and the Defense Technical Information Center public site was conducted on May 2, 2016. Studies that described penetrating SCI with shrapnel as an etiology, included surgical and/or conservative management, and demonstrated admission and follow-up neurological status were eligible for inclusion in this study...
October 20, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29053034/circadian-rest-activity-rhythm-in-chronic-obstructive-pulmonary-disease
#9
Deuzilane Muniz Nunes, Bruno S B Gonçalves, Carina Aparecida Tardelli Peixoto, Veralice Meireles Sales De Bruin, Fernando Mazzilli Louzada, Pedro Felipe Carvalhedo De Bruin
To characterize circadian rest-activity rhythm in COPD, 26 cases (66.9 ± 8.5y) and 15 controls (63.0 ± 10.7y) were assessed by actimetry. Rhythm fragmentation was measured by intradaily variability (IV), while synchronization to the 24-h light-dark cycle was measured by interdaily stability (IS). The average activity during the least active 5-h period (L5) and the average activity during the most active 10-h period (M10) were used to calculate the relative amplitude mean [RAm = (M10-L5)/(M10+L5)]. COPD patients presented higher IVm (0...
October 20, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29053018/genetic-association-of-polymorphisms-in-axin1-gene-with-clear-cell-renal-cell-carcinoma-in-a-chinese-population
#10
Yan Pu, Xuhua Mi, Peng Chen, Bin Zhou, Peng Zhang, Yanyun Wang, Yaping Song, Lin Zhang
AIM: The purpose of the present study is to investigate the association between the polymorphisms in AXIN1 with susceptibility to clear cell renal cell carcinoma (ccRCC). MATERIALS & METHODS:  A total of 284 ccRCC patients and 439 healthy volunteers were enrolled. Totally three tag single nucleotide polymorphisms in AXIN1 gene were genotyped using PCR & restriction fragment length polymorphism. RESULTS: Significantly increased ccRCC risk was observed to be associated with the CT/CC genotypes of rs1805105 and AA genotype of rs12921862...
October 20, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29052960/treatment-and-outcomes-of-melanoma-in-asia-results-from-the-national-cancer-centre-singapore
#11
Yi Lin Teh, Wei Lin Goh, Sze Huey Tan, Grace Yong, Alisa Noor Hidayah Sairi, Khee Chee Soo, Johnny Ong, Claramae Chia, Grace Tan, Henry Soeharno, Mann Hong Tan, Michelle Chan, Selvarajan Sathiyamoorthy, Kesavan Sittampalam, Jonathan Teh, Francis Chin, Vijay Sethi, Melissa Teo, Richard Quek, Mohamad Farid
BACKGROUND: Acral melanoma (AM) and mucosal melanoma (MM) make up more than half of melanomas in Asia but comprise only 5% of cases in Caucasians, where cutaneous melanoma (CM) predominates. AM and MM are thought to be genetically and biologically distinct from CM. We report the characteristics and outcomes of melanoma patients from the National Cancer Centre Singapore. METHODS: Case records of 210 patients treated between 2002 and 2014 were reviewed. RESULTS: Median follow-up was 2...
October 20, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29052935/relationship-between-chronic-kidney-disease-without-diabetes-mellitus-and-components-of-frailty-in-community-dwelling-japanese-older-adults
#12
Sungchul Lee, Sangyoon Lee, Seongryu Bae, Kazuhiro Harada, Songee Jung, Masakazu Imaoka, Hyuma Makizako, Takehiko Doi, Hiroyuki Shimada
AIM: To evaluate the relationship between kidney function without diabetes and components of the frailty phenotype in community-dwelling Japanese older adults. METHODS: Participants were 8343 residents who completed baseline assessments, classified into four categories according to eGFR. Frailty status was defined using five criteria: (i) slow gait speed; (ii) muscle weakness; (iii) low physical activity; (iv) exhaustion; and (v) unintentional weight loss. RESULTS: After multivariate adjustment, participants with the lowest kidney function were at higher risk of frailty (OR 1...
October 20, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29052805/sublingual-buprenorphine-efficacy-in-renal-colic-pain-relief-a-randomized-placebo-controlled-clinical-trial
#13
Javad Mozafari, Kambiz Masoumi, Arash Forouzan, Hassan Motamed, Malehi Amal Saki, Marzieh Dezham
INTRODUCTION: This study was designed to compare the analgesic efficacy of sublingual (SL) buprenorphine and intravenous (IV) ketorolac for renal colic pain relief. METHODS: The present study was carried out as a double-blind, double-dummy randomized clinical trial in patients diagnosed with acute renal colic attending the emergency department. The study subjects were 63 patients with confirmed renal stones. The subjects were randomly divided into two groups. One group, which included 32 patients, received SL buprenorphine tablets (2 mg) with an IV placebo, and another group, including 31 patients, received ketorolac tromethamine (30 mg) with a SL placebo...
October 20, 2017: Pain and Therapy
https://www.readbyqxmd.com/read/29052788/sequence-analysis-of-six-full-length-bean-yellow-mosaic-virus-genomes-reveals-phylogenetic-diversity-in-india-strains-suggesting-subdivision-of-phylogenetic-group-iv
#14
Charanjeet Kaur, Rashmi Raj, Ashish Srivastava, Susheel Kumar, Shri Krishna Raj
We report the complete genome sequence of five bean yellow mosaic virus (BYMV) isolates (CK-GL1, CK-GL3, CK-GL4, CK-GL5 and Vfaba2) that share 74.6-98.9% (nucleotide) and 81.5-99.1% (amino acid) identity with globally available BYMV sequences. Phylogenetic analysis clustered them specifically in BYMV phylogenetic group-IV within the existing nine groups. The CK-GL1, CK-GL2, CK-GL4 and CK-GL5 isolates formed a discrete cluster within group-IV. The present study suggests subdivision of group-IV into subgroup-IVa and IVb...
October 20, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29052349/relationship-between-ugt1a1-27-and-ugt1a1-7-polymorphisms-and-irinotecan-related-toxicities-in-patients-with-lung-cancer
#15
Minoru Fukuda, Manabu Okumura, Tomomi Iwakiri, Kazuhiko Arimori, Takuya Honda, Kazuma Kobayashi, Hiroaki Senju, Shinnosuke Takemoto, Takaya Ikeda, Hiroyuki Yamaguchi, Katsumi Nakatomi, Nobuko Matsuo, Hiroshi Mukae, Kazuto Ashizawa
BACKGROUND: The objective of this study was to evaluate the effects of gene polymorphisms, including UGT1A1*7, *27, and *29, on the safety of irinotecan therapy. METHODS: The eligibility criteria were: lung cancer patients scheduled to undergo irinotecan therapy, aged ≥ 20 years, with a performance status of 0-2. Thirty-one patients were enrolled and their blood was collected and used to examine the frequency of UGT1A1*6, *7, *27, *28, and *29 polymorphisms and the concentrations of irinotecan, SN-38, and SN-38G after irinotecan therapy...
October 20, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/29052319/from-pre-ovulatory-follicle-palpation-to-the-challenge-of-twin-pregnancies-clinical-reflections-following-one-million-gynaecological-examinations-in-dairy-cows
#16
REVIEW
F López-Gatius, R H F Hunter
Based on experimental studies and extensive field-scale experience, this review offers new proposals for: (i) elevating the success of modern insemination procedures, (ii) emphasizing features of a pre-ovulatory follicle in the context of optimum insemination timing, (iii) overcoming heat stress and its consequences using physiological processes or endocrine protocols, (iv) establishing a viable pregnancy or early pregnancy loss and (v) the challenge of twin pregnancies. In conclusion, the fertility of high-yielding dairy cows can be further improved...
October 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29052159/recommended-methods-for-the-collection-of-health-state-utility-value-evidence-in-clinical-studies
#17
REVIEW
Roberta Ara, John Brazier, Tracey Young
A conceptual model framework and an initial literature review are invaluable when considering what health state utility values (HSUVs) are required to populate health states in decision models. They are the recommended starting point early within a research and development programme, and before development of phase III trial protocols. While clinical trials can provide an opportunity to collect the required evidence, their appropriateness should be reviewed against the requirements of the model structure taking into account population characteristics, time horizon and frequency of clinical events...
October 19, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29052073/laparoscopy-for-primary-cytoreduction-with-multivisceral-resections-in-advanced-ovarian-cancer-prospective-validation-the-times-they-are-a-changin
#18
Marcello Ceccaroni, Giovanni Roviglione, Francesco Bruni, Roberto Clarizia, Giacomo Ruffo, Matteo Salgarello, Michele Peiretti, Stefano Uccella
BACKGROUND: Primary cytoreduction is the mainstay of treatment for advanced ovarian cancer (AOC). We developed and prospectively evaluated an algorithm to investigate the possible role of laparoscopic primary cytoreduction (LPC) in carefully selected patients, with AOC. METHODS: From June 2007 to July 2015, all patients with stage III-IV ovarian cancer and clinical conditions allowing aggressive surgery were candidate to primary cytoreduction with the aim of achieving residual tumor (RT) = 0...
October 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29052052/long-term-outcomes-of-endoscopic-submucosal-dissection-versus-surgery-in-early-gastric-cancer-meeting-expanded-indication-including-undifferentiated-type-tumors-a-criteria-based-analysis
#19
Sunpyo Lee, Kee Don Choi, Minkyu Han, Hee Kyong Na, Ji Yong Ahn, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Ho June Song, Gin Hyug Lee, Jeong-Hwan Yook, Byung Sik Kim, Hwoon-Yong Jung
BACKGROUND: Endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) meeting the expanded indication is considered investigational. We aimed to compare long-term outcomes of ESD and surgery for EGC in the expanded indication based on each criterion. METHODS: This study included 1823 consecutive EGC patients meeting expanded indication conditions and treated at a tertiary referral center: 916 and 907 patients underwent surgery or ESD, respectively. The expanded indication included four discrete criteria: (I) intramucosal differentiated tumor, without ulcers, size >2 cm; (II) intramucosal differentiated tumor, with ulcers, size ≤3 cm; (III) intramucosal undifferentiated tumor, without ulcers, size ≤2 cm; and (IV) submucosal invasion <500 μm (sm1), differentiated tumor, size ≤3 cm...
October 19, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29051981/preoperative-optimization-of-patients-with-inflammatory-bowel-disease-undergoing-gastrointestinal-surgery-a-systematic-review
#20
REVIEW
Marie Strøm Zangenberg, Nir Horesh, Uri Kopylov, Alaa El-Hussuna
PURPOSE: Surgical management of inflammatory bowel disease (IBD) is a challenging task. The aim of preoperative optimization (PO) is to decrease the risk of complications and reduce the length of postoperative stay. The aim of this study was to review and grade the available evidence, attain clear recommendations, and point out potential future research. METHODS: Studies were identified from electronic databases (PubMed, Embase, and Cochrane Library) and scanning reference lists in relevant papers...
October 19, 2017: International Journal of Colorectal Disease
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