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https://www.readbyqxmd.com/read/29677681/pphb22-a-member-of-hd-zip-proteins-activates-ppdam1-to-regulate-bud-dormancy-transition-in-suli-pear-pyrus-pyrifolia-white-pear-group
#1
Qinsong Yang, Qingfeng Niu, Jianzhao Li, Xiaoyan Zheng, Yunjing Ma, Songling Bai, Yuanwen Teng
Homeodomain-leucine zipper (HD-Zip) proteins, which form one of the largest and most diverse families, regulate many biological processes in plants, including differentiation, flowering, vascular development, and stress signaling. Abscisic acid (ABA) has been proved to be one of the key regulators of bud dormancy and to influence several HD-Zip genes expression. However, the role of HD-Zip genes in regulating bud dormancy remains unclear. We identified 47 pear (P. pyrifolia White Pear Group) HD-Zip genes, which were classified into four subfamilies (HD-Zip I-IV)...
April 5, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29677667/co-evolutionary-dynamics-of-the-human-environment-system-in-the-heihe-river-basin-in-the-past-2000years
#2
Zhixiang Lu, Yongping Wei, Qi Feng, Jiali Xie, Honglang Xiao, Guodong Cheng
There is limited quantitative understanding of interactions between human and environmental systems over the millennial scale. We aim to reveal the co-evolutionary dynamics of the human-environment system in a river basin by simulating the water use and net primary production (NPP) allocation for human and environmental systems over the last 2000years in Heihe River basin (HRB) in northwest China. We partition the catchment total evapotranspiration (ET) into ET for human and environmental systems with a social-hydrological framework and estimate the NPP for human and environmental systems using the Box-Lieth model, then classify the co-evolutionary processes of the human-environment system into distinct phases using the rate of changes of NPP over time, and discover the trade-offs or synergies relationships between them based on the elasticity of change of the NPP for humans to the change of NPP for environment...
April 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29677463/a-role-for-collagen-iv-in-cardiovascular-disease
#3
Lasse Bach Steffensen, Lars M Rasmussen
Over the past decade, studies have repeatedly found single nucleotide polymorphisms located in the COL4A1 and COL4A2 genes to be associated with cardiovascular disease (CVD), and the 13q34 locus harboring these genes is one of approximately 160 genome-wide significant risk loci for coronary artery disease. COL4A1 and COL4A2 encode the ⍺1- and ⍺2-chains of collagen IV, a major component of basement membranes in various tissues including arteries. In spite of the growing body of evidence indicating a role for collagen IV in CVD, remarkably few studies aim at directly investigating such a role...
April 20, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29677210/provider-reported-barriers-and-solutions-to-improve-testing-among-tuberculosis-patients-eligible-for-drug-susceptibility-test-a-qualitative-study-from-programmatic-setting-in-india
#4
Hemant Deepak Shewade, Arun M Kokane, Akash Ranjan Singh, Malik Parmar, Manoj Verma, Prabha Desikan, Sheeba Naz Khan, Ajay M V Kumar
BACKGROUND: In a study conducted in Bhopal district (a setting with facility for molecular drug susceptibility testing (DST)) located in central India in 2014-15, we found high levels of pre-diagnosis attrition among patients with presumptive multi drug-resistant tuberculosis (MDR-TB)-meaning TB patients who were eligible for DST, were not being tested. OBJECTIVES: In this study, we explored the health care provider perspectives into barriers and suggested solutions for improving DST...
2018: PloS One
https://www.readbyqxmd.com/read/29677187/breastfeeding-during-infancy-and-neurocognitive-function-in-adolescence-16-year-follow-up-of-the-probit-cluster-randomized-trial
#5
Seungmi Yang, Richard M Martin, Emily Oken, Mikhail Hameza, Glen Doniger, Shimon Amit, Rita Patel, Jennifer Thompson, Sheryl L Rifas-Shiman, Konstantin Vilchuck, Natalia Bogdanovich, Michael S Kramer
BACKGROUND: Evidence on the long-term effect of breastfeeding on neurocognitive development is based almost exclusively on observational studies. In the 16-year follow-up study of a large, cluster-randomized trial of a breastfeeding promotion intervention, we evaluated the long-term persistence of the neurocognitive benefits of the breastfeeding promotion intervention previously observed at early school age. METHODS AND FINDINGS: A total of 13,557 participants (79...
April 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29677078/therapeutic-outcomes-of-haploidentical-allogeneic-hematopoietic-stem-cell-transplantation-in-patients-with-severe-aplastic-anemia-a-multicenter-study
#6
Yonghua Li, Fengqi Duan, Haowen Xiao, Xiaoxiong Wu, Shunqing Wang, Duorong Xu, Qifa Liu, Zhiping Fan, Danian Nie, Yongrong Lai, Bingyi Wu, Dongjun Lin, Xin Du, Jianyu Weng, Xin Du, Zujun Jiang, Yan Pang, Lin Ouyang, Zenghui Liu, Leqin Zhang, Na Han, Lixuan Chen, Yang Xiao
BACKGROUND: Haploidentical donor allogeneic hematopoietic stem cell transplantation (HID-HSCT) is an alternative curative treatment for patients with severe aplastic anemia (SAA) who do not have suitable matched related donors (MRD). The aim of this study was to compare the therapeutic outcomes of HID-HSCT with those of MRD-HSCT for SAA. METHODS: A total of 235 SAA patients who underwent HID-HSCT (116) or MRD-HSCT (119) at 11 transplantation centers from January 2007 to January 2016 were included...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29676947/intravenous-chemotherapy-compounding-errors-in-a-follow-up-pan-canadian-observational-study
#7
Rachel E Gilbert, Melissa C Kozak, Roxanne B Dobish, Venetia C Bourrier, Paul M Koke, Vishal Kukreti, Heather A Logan, Anthony C Easty, Patricia L Trbovich
PURPOSE: Intravenous (IV) compounding safety has garnered recent attention as a result of high-profile incidents, awareness efforts from the safety community, and increasingly stringent practice standards. New research with more-sensitive error detection techniques continues to reinforce that error rates with manual IV compounding are unacceptably high. In 2014, our team published an observational study that described three types of previously unrecognized and potentially catastrophic latent chemotherapy preparation errors in Canadian oncology pharmacies that would otherwise be undetectable...
April 20, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29676901/polar-imperfections-in-amino-acid-crystals-design-structure-and-emerging-functionalities
#8
Elena Meirzadeh, Isabelle Weissbuch, David Ehre, Meir Lahav, Igor Lubomirsky
Crystals are physical arrays delineated by polar surfaces and often contain imperfections of a polar nature. Understanding the structure of such defects on the molecular level is of topical importance since they strongly affect the macroscopic properties of materials. Moreover, polar imperfections in crystals can be created intentionally and specifically designed by doping nonpolar crystals with "tailor-made" additives as dopants, since their incorporation generally takes place in a polar mode. Insertion of dopants also induces a polar deformation of neighboring host molecules, resulting in the creation of polar domains within the crystals...
April 20, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29676727/characterization-of-sccmec-type-iv-methicillin-resistant-staphylococcus-aureus-clones-increased-in-japanese-hospitals
#9
Hidemasa Nakaminami, Shunsuke Takadama, Ayumu Ito, Mariko Hasegawa, Chika Jono, Miyuki Noguchi, Manami Shoshi, Takeaki Wajima, Takeshi Fujii, Hiroshi Maruyama, Haruo Sakamoto, Yutaka Ito, Satsuki Okamoto, Yukiyoshi Masaki, Kayoko Tsuchiya, Susumu Nishinarita, Norihisa Noguchi
Recently, the prevalence of staphylococcal cassette chromosome mec (SCCmec) type IV isolates, which are the major community-acquired methicillin-resistant Staphylococcus aureus (MRSA), have increased in Japanese hospitals. The aim of this study was to elucidate the detailed molecular epidemiological features of the SCCmec type IV clones in Japanese hospitals. When 2589 MRSA isolated from four hospitals in Tokyo, Japan between 2010 and 2014 were analysed, the proportion of SCCmec type IV overtook that of type II, which was the major type of hospital-acquired MRSA in 2014...
April 20, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29676720/mutagenic-repair-of-double-stranded-dna-breaks-in-vaccinia-virus-genomes-requires-cellular-dna-ligase-iv-activity-in-the-cytosol
#10
Rutger David Luteijn, Ingo Drexler, Geoffrey L Smith, Robert Jan Lebbink, Emmanuel J H J Wiertz
Poxviruses comprise a group of large dsDNA viruses that include members relevant to human and animal health, such as variola virus, monkeypox virus, cowpox virus and vaccinia virus (VACV). Poxviruses are remarkable for their unique replication cycle, which is restricted to the cytoplasm of infected cells. The independence from the host nucleus requires poxviruses to encode most of the enzymes involved in DNA replication, transcription and processing. Here, we use the CRISPR/Cas9 genome engineering system to induce DNA damage to VACV (strain Western Reserve) genomes...
April 20, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29676697/the-transcortical-equatorial-approach-for-gliomas-of-the-mesial-temporal-lobe-techniques-and-functional-outcomes
#11
Ramin A Morshed, Jacob S Young, Seunggu J Han, Shawn L Hervey-Jumper, Mitchel S Berger
OBJECTIVE Many surgical approaches have been described for lesions within the mesial temporal lobe (MTL), but there are limited reports on the transcortical approach for the resection of tumors within this region. Here, the authors describe the technical considerations and functional outcomes in patients undergoing transcortical resection of gliomas of the MTL. METHODS Patients with a glioma (WHO grades I-IV) located within the MTL who had undergone the transcortical approach in the period between 1998 and 2016 were identified through the University of California, San Francisco (UCSF) tumor registry and were classified according to tumor location: preuncus, uncus, hippocampus/parahippocampus, and various combinations of the former groups...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676689/intravenous-acetaminophen-for-postoperative-supratentorial-craniotomy-pain-a-prospective-randomized-double-blinded-placebo-controlled-trial
#12
Walavan Sivakumar, Michael Jensen, Julie Martinez, Michael Tanana, Nancy Duncan, Robert Hoesch, Jay K Riva-Cambrin, Craig Kilburg, Safdar Ansari, Paul A House
OBJECTIVE Acute pain control after cranial surgery is challenging. Prior research has shown that patients experience inadequate pain control post-craniotomy. The use of oral medications is sometimes delayed because of postoperative nausea, and the use of narcotics can impair the evaluation of brain function and thus are used judiciously. Few nonnarcotic intravenous (IV) analgesics exist. The authors present the results of the first prospective study evaluating the use of IV acetaminophen in patients after elective craniotomy...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676681/frameless-robot-assisted-stereoelectroencephalography-in-children-technical-aspects-and-comparison-with-talairach-frame-technique
#13
Taylor J Abel, René Varela Osorio, Ricardo Amorim-Leite, Francois Mathieu, Philippe Kahane, Lorella Minotti, Dominique Hoffmann, Stephan Chabardes
OBJECTIVE Robot-assisted stereoelectroencephalography (SEEG) is gaining popularity as a technique for localization of the epileptogenic zone (EZ) in children with pharmacoresistant epilepsy. Here, the authors describe their frameless robot-assisted SEEG technique and report preliminary outcomes and relative complications in children as compared to results with the Talairach frame-based SEEG technique. METHODS The authors retrospectively analyzed the results of 19 robot-assisted SEEG electrode implantations in 17 consecutive children (age < 17 years) with pharmacoresistant epilepsy, and compared these results to 19 preceding SEEG electrode implantations in 18 children who underwent the traditional Talairach frame-based SEEG electrode implantation...
April 20, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29676482/severe-heart-failure-nyha-class-iv-is-associated-with-increased-left-ventricular-mass-index-and-short-mitral-deceleration-time-in-severe-aortic-valve-stenosis
#14
Sayuki Kobayashi, Hiroto Utsunomiya, Takahiro Shiota
BACKGROUND: In aortic valve stenosis (AS), congestive heart failure (CHF) is a well-established symptom that indicates the need for surgical aortic valve replacement (SAVR). However, it is difficult to judge whether CHF symptoms such as dyspnea are caused by severe AS or other conditions, especially in elderly persons with restricted mobility or other organ complications. It is important to identify objective and noninvasive parameters associated with severe CHF symptoms in severe AS...
April 20, 2018: Echocardiography
https://www.readbyqxmd.com/read/29676403/combined-endoscopic-transorbital-and-endonasal-repair-of-high-flow-orbital-apex-middle-fossa-cerebrospinal-fluid-leak-with-a-nasoseptal-flap
#15
Brandon Lucke-Wold, Gustavo Mendez, David Cua, Paul Akins, Haley Gillham, Jeremy Ciporen
Background and importance: High flow orbital apex or middle fossa cerebrospinal fluid (CSF) leaks can be life threatening and complex to repair. These leaks associated with large dural defects are most commonly repaired with an open temporalis muscle patch or free flaps, but these flaps do not always stop the leak. Clinical Presentation: A 65-year-old patient presented two years after orbital exenteration and radiation for squamous cell carcinoma. He developed multi-organism meningitis and pneumocephalus secondary to a large high-flow orbital apex/middle fossa CSF leak...
2018: J Neuroinflamm Neurodegener Dis
https://www.readbyqxmd.com/read/29676357/is-a-diagnostic-lumbar-puncture-indicated-in-intraocular-retinoblastoma
#16
Sidharth Totadri, Vinay Munikoty, Usha Singh, Radhika Srinivasan, Amita Trehan, Richa Jain, Nandita Kakkar, Akshay Kumar Saxena, Arvind Rajwanshi, Deepak Bansal
Background: Lumbar puncture (LP) is frequently performed in patients with advanced intraocular retinoblastoma. However, this may not be necessary in a significant proportion of patients. Materials and Methods: A file review of patients who were diagnosed with retinoblastoma over a 13-year-period was performed. Patients who underwent LP as part of staging were included in the study. Results: The study included 223 patients. One-third had bilateral retinoblastoma...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29676227/chemically-modified-mrna-modified-rna-application-for-treatment-of-achilles-tendon-defects
#17
Elmar Herbst, Florian Imhoff, Peter Föhr, Stefan Milz, Christian Plank, Carsten Rudolph, Günther Hasenpusch, Johannes Geiger, Manish Aneja, Karoline Groth, Stephan Vogt, Andreas Imhoff, Andreas Schmitt
Different regenerative medicine approaches for tendon healing exist. Recently, especially gene therapy gained popularity. However, potential mutagenic and immunologic effects might prevent from translation to clinical research. Chemically modified mRNA (cmRNA) might bypass these limitations of gene therapy. Therefore, the purpose of this study was to evaluate the early healing properties of Achilles tendon defects in rats treated with basic fibroblast growth factor (bFGF) cmRNA. Forty male Lewis rats were used for the study and randomly assigned to the two study groups: 1) treatment with cmRNA coding for bFGF, 2) non-coding cmRNA control...
April 20, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29675948/pattern-of-care-and-survival-of-anaplastic-lymphoma-kinase-rearranged-non-small-cell-lung-cancer-alk-nsclc-in-an-australian-metropolitan-tertiary-referral-centre-a-retrospective-cohort-analysis
#18
Malinda Itchins, Sarah A Hayes, Anthony J Gill, Wendy Cooper, Rachel O'Connell, Viive M Howell, Stephen J Clarke, Nick Pavlakis
AIM: To report on the pattern of care and survival of anaplastic lymphoma kinase rearranged non-small cell lung cancer (ALK+NSCLC) in a real-world retrospective cohort from an Australian tertiary referral center. METHODS: Individuals with a pathological diagnosis of ALK+NSCLC via immunohistochemistry and fluorescence in situ hybridization and a radiological diagnosis of stage IV disease were eligible. Patients were identified via the Pathology Department specimen database and electronic patient chart review...
April 19, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29675944/advanced-mr-diffusion-imaging-and-chemotherapy-related-changes-in-cerebral-white-matter-microstructure-of-survivors-of-childhood-bone-and-soft-tissue-sarcoma
#19
Charlotte Sleurs, Jurgen Lemiere, Daan Christiaens, Thibo Billiet, Ronald Peeters, Stefan Sunaert, Anne Uyttebroeck, Sabine Deprez
With the increase of survival rates of pediatric cancer patients, the number of children facing potential cognitive sequelae has grown. Previous adult studies suggest that white matter (WM) microstructural changes may contribute to cognitive impairment. This study aims to investigate WM microstructure in childhood bone and soft tissue sarcoma. Differences in (micro-)structure can be investigated using diffusion MRI (dMRI). The typically used diffusion tensor model (DTI) assumes Gaussian diffusion, and lacks information about fiber populations...
April 20, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29675916/serum-apoa4-levels-predicted-the-progression-of-renal-impairment-in-t2dm
#20
Chao-Wen Cheng, Che-Chang Chang, Hsiu-Wen Chen, Ching-Yu Lin, Jin-Shuen Chen
BACKGROUND: Among multiple causes, diabetic nephropathy (DN) is the major underlying renal disease that leads to end-stage renal disease (ESRD), and early diagnosis can effectively prevent or delay the progression to ESRD. Therefore, the current study aimed to develop non-invasive, accurate detection markers. MATERIALS & METHODS: For this study, 62 diabetes mellitus (DM) patients, 59 DN patients, and 21 healthy controls (HCs) were recruited. All participants' serum samples were subjected to concavanalin (Con) A affinity chromatography, which utilizes glycoproteins to discover potential markers...
April 19, 2018: European Journal of Clinical Investigation
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