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https://www.readbyqxmd.com/read/29935486/comparison-of-intravenous-ibuprofen-and-acetaminophen-for-postoperative-multimodal-pain-management-in-bariatric-surgery-a-randomized-controlled-trial
#1
Gulay Erdogan Kayhan, Mukadder Sanli, Ulku Ozgul, Ramazan Kirteke, Saim Yologlu
STUDY OBJECTIVE: Multimodal analgesic strategies are recommended to decrease opioid requirements and opioid-induced respiratory complications in patients undergoing laparoscopic bariatric surgery. Recent studies have demonstrated that intravenous ibuprofen decreases opioid consumption compared with placebo. The primary aim of this study was to compare the effect of intravenous ibuprofen and intravenous acetaminophen on opioid consumption. We also aimed to compare postoperative pain levels and side effects of the drugs...
June 20, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29935381/east-south-east-asian-ethnicity-and-moderate-to-severe-endometriosis
#2
Christina Williams, Alicia J Long, Heather Noga, Catherine Allaire, Mohamed A Bedaiwy, Sarka Lisonkova, Paul J Yong
STUDY OBJECTIVE: To investigate ethnic differences for moderate-to-severe endometriosis DESIGN: Analysis of a prospective registry, December 2013 - December 2016 (ClinicalTrials.gov # NCT02911090). INCLUSION CRITERIA: Women presenting to tertiary referral center for pelvic pain and/or endometriosis. EXCLUSION CRITERIA: Age greater than 50, menopausal, or mixed ethnicity. Logistic regression analysis was used to obtain adjusted odds ratios (aOR) and 95% confidence intervals (CI) adjusting for potential confounders (e...
June 20, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29935368/long-term-survival-after-partial-hepatectomy-for-sub-stage-patients-with-intermediate-stage-hepatocellular-carcinoma
#3
Wen-Xin Wei, Zhi-Shi Yang, Li-Hua Lu, Jun Li, Zheng-Qing Lei, Kui Wang, Yong Xia, Zhen-Lin Yan, Feng Shen
BACKGROUND: The current study aimed to examine the long-term survival after partial hepatectomy for patients with BCLC intermediate stage hepatocellular carcinoma (HCC) stratified by the Bolondi's sub-staging model. MATERIALS AND METHODS: This cohort consisted of 360 patients with BCLC intermediate stage HCC who underwent partial hepatectomy between January 2008 and February 2010. Patients were stratified into 3 subgroups (B1-B3) based on the Bolondi's sub-staging model...
June 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29935334/treatment-of-large-deep-osteochondritis-lesions-of-the-knee-by-autologous-matrix-induced-chondrogenesis-amic-preliminary-results-in-13-patients
#4
Pierre Bertho, Adrien Pauvert, Thomas Pouderoux, Henri Robert
BACKGROUND: Osteo-chondral defects due to advanced osteochondritis of the knee eventually cause osteoarthritis. Autologous matrix-induced chondrogenesis (AMIC) may hold potential for overcoming the treatment challenges raised by defects larger than 2 cm2 . The primary objective of this study was to assess medium-term functional outcomes of AMIC. The secondary objective was to confirm the absence of adverse events. HYPOTHESIS: AMIC significantly improves knee function in patients with osteochondritis responsible for osteo-chondral defects grade III or IV in the International Cartilage Repair Society (ICRS) classification...
June 20, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29935252/what-is-the-relationship-between-incarceration-of-children-and-adult-health-outcomes
#5
Elizabeth S Barnert, Laura S Abrams, Rebecca Dudovitz, Tumaini R Coker, Eraka Bath, Lello Tesema, Bergen B Nelson, Christopher Biely, Paul J Chung
OBJECTIVE: We sought to quantify the association between child incarceration in the U.S. and subsequent adult health outcomes. METHODS: We analyzed National Longitudinal Study of Adolescent to Adult Health data from 1,727 adult (Wave IV) participants first incarcerated at age <25. Using Chi-squared tests and multivariate logistic regression models, we compare adult health outcomes (mobility limitations, depressive symptoms, suicidal thoughts) among those first incarcerated at age ≤14, 15-17, and 18-20, with 21-24 as the reference group...
June 20, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29935218/staphylococcus-aureus-impairs-sinonasal-epithelial-repair-effects-in-crswnp-and-control-subjects
#6
Fabiana Cp Valera, Manon Ruffin, Damien Adam, Émilie Maillé, Badr Ibrahim, Julie Berube, Simon Rousseau, Emmanuelle Brochiero, Martin Y Desrosiers
BACKGROUND: The impact of Staphylococcus aureus (SA) on nasal epithelial repair has never been assessed in chronic rhinosinusitis with nasal polyps (CRSwNP). OBJECTIVE: This study aimed to determine whether: i) nasal epithelial cell cultures from patients with CRSwNP and control subjects repair differently; ii) SA exoproducts compromise nasal epithelial repair; iii) SA alters lamellipodial dynamics; and iv) deleterious effects could be counteracted by the ROCK inhibitor Y-27632...
June 20, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29935194/matrix-metalloproteinase-14-induces-epithelial-to-mesenchymal-transition-in-synovial-sarcoma
#7
Manli Liu, Yan Qi, Lili Zhao, Dongdong Chen, Yang Zhou, Hongrun Zhou, Yanmin Lv, Lu Zhang, Shan Jin, Shugang Li, Hong Zou, Wei Jia, Cuicui Wang, Jinfang Jiang, Weihua Liang, Lijuan Pang, Feng Li
Synovial sarcoma (SS) is a highly aggressive malignant soft tissue sarcoma with typical characteristics of both epithelial and mesenchymal differentiation. Matrix metalloproteinase-14 (MMP-14) is reported to play an important role in some of these tumors. It induces epithelial-to-mesenchymal transition (EMT) in some carcinomas, such as breast and prostate cancers. However, the role of MMP-14 in the pathogenesis of SS remains unclear. Therefore, we investigated the role of MMP-14 and EMT/mesenchymal-to-epithelial transition (MET) in SS...
June 20, 2018: Human Pathology
https://www.readbyqxmd.com/read/29935156/ag-1031-and-ag-1503-improve-cognitive-deficits-by-promoting-apoptosis-and-inhibiting-autophagy-in-c6-glioma-model-rats
#8
Shuang Hao, Jing Gao, Hui Wang, Yan Zhang, Andrey Pavlov, Hui Ge, Zhuo Yang
High-grade gliomas (HGGs; grades III and IV) are the most common and aggressive adult primary brain tumors, and their invasive nature ranks them the fourth in the incidence of cancer death. In our previous study, we found that AG-1031 and AG-1503 showed inhibitory effects on several cancer cell lines. In this study, C6 glioma-bearing rats were treated with AG-1031 or AG-1503. Western blot results of autophagy-associated protein (LC3 II/I, Beclin-1) and apoptosis-associated proteins (caspase-3, Bcl-2, Bax) revealed that AG-1031 could activate apoptotic signal pathway via inhibiting autophagy process in cancer cells...
June 20, 2018: Brain Research
https://www.readbyqxmd.com/read/29935073/anti-oxidative-and-anti-apoptotic-effects-of-apigenin-on-number-of-viable-and-apoptotic-blastomeres-zona-pellucida-thickness-and-hatching-rate-of-mouse-embryos
#9
Manouchehr Safari, Houman Parsaie, Hamid Reza Sameni, Mohammad Reza Aldaghi, Sam Zarbakhsh
BACKGROUND: Apigenin is a plant-derived compound belonging to the flavonoids category and bears protective effects on different cells. The aim of this study was to evaluate the effect of apigenin on the number of viable and apoptotic blastomeres, the zona pellucida (ZP) thickness and hatching rate of pre-implantation mouse embryos exposed to H2 O2 and actinomycin D. MATERIALS AND METHODS: In this experimental study, 420 two-cell embryos were randomly divided into six groups: i...
June 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29935072/histopathological-effects-of-titanium-dioxide-nanoparticles-and-the-possible-protective-role-of-n-acetylcysteine-on-the-testes-of-male-albino-rats
#10
Amir M Bassam Elnagar, Abdelnasser Ibrahim, Amro Mohamed Soliman
BACKGROUND: Titanium dioxide (TiO2 ) is a white pigment which is used in paints, plastics, etc. It is reported that TiO2 induces oxidative stress and DNA damage. N-acetylcysteine (NAC) has been used to fight oxidative stress-induced damage in different tissues. The objective of this study was to evaluate the toxic effects of orally administered TiO2 nanoparticles and the possible protective effect of NAC on the testes of adult male albino rats. MATERIALS AND METHODS: In this experimental study, 50 adult male albino rats were classified into five groups...
June 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29935070/flaxseed-can-reduce-hypoxia-induced-damages-in-rat-testes
#11
Mahnaz Poorhassan, Fatemeh Navae, Simin Mahakizadeh, Mahshid Bazrafkan, Banafshe Nikmehr, Farid Abolhassani, Sahar Ijaz, Nazila Yamini, Nasrin Dashti, Kobra Mehrannia, G holamReza Hassanzadeh, Mohammad Akbari
BACHGROUND: Hypoxia causes detrimental effects on the structure and function of tissues through increased production of reactive oxygen species that are generated during the re-oxygenation phase of intermittent and continuous hypobaric hypoxia. This study was carried out to evaluate the effects of flaxseed (Fx) in reducing the incidence of hypoxia in rat testes. MATERIALS AND METHODS: In this experimental study, 24 adult Wistar rats were randomly divided into four groups: i...
June 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29935020/optimisation-of-a-capillary-zone-electrophoresis-contactless-conductivity-detection-method-for-determination-of-nisin
#12
Tomas Drevinskas, Mantas Stankevičius, Kristina Bimbiraitė-Survilienė, Gintarė Naujokaitytė, Vilma Kaškonienė, Kristina Kondrotienė, Loreta Šernienė, Olga Kornyšova, Mindaugas Malakauskas, Audrius Maruška
Determination of natural preservatives using electrophoretic, or chromatographic techniques in fermented milk products is a complex task due to the following reasons: (i) the concentrations of the analytes can be below the detection limits, (ii) complex matrix and comigrating / coeluting compounds in the sample can interfere with the analytes of the interest, (iii) low recovery of the analytes and (iv) complex sample preparation is necessary. The aim of this study was to apply capillary zone electrophoresis coupled with contactless conductivity detection for the separation and determination of nisin in fermented milk products...
June 23, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29934845/executive-dysfunctions-differentially-predict-amotivation-in-first-episode-schizophrenia-spectrum-disorder-a-prospective-1-year-follow-up-study
#13
Wing Chung Chang, Jasmine Tsz Ting Liu, Christy Lai Ming Hui, Sherry Kit Wa Chan, Edwin Ho Ming Lee, Yi Nam Suen, Eric Yu Hai Chen
Amotivation is a major determinant of functional outcome in schizophrenia but it is understudied in the early course of illness. There is a paucity of longitudinal research investigating predictors of amotivation. In this study, we aimed to examine baseline cognitive and clinical predictors of amotivation at 6 and 12 months of follow-up in patients aged 18-55 years presenting with first-episode DSM-IV schizophrenia-spectrum disorder (FES). Of 145 patients recruited at intake, 116 and 113 completed assessments at 6- and 12-month follow-up, respectively...
June 22, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29934756/striatal-reinnervation-process-after-acute-methamphetamine-induced-dopaminergic-degeneration-in-mice
#14
Noelia Granado, Sara Ares-Santos, Yousef Tizabi, Rosario Moratalla
Methamphetamine (METH), an amphetamine derivate, may increase the risk of developing Parkinson's disease (PD). Human and animal studies have shown that METH produces persistent dopaminergic neurotoxicity in the nigrostriatal pathway, despite initial partial recovery. To determine the processes leading to early compensation, we studied the detailed morphology and distribution of tyrosine hydroxylase immunoreactive fibers (TH-ir) classified by their thickness (types I-IV) before and after METH. Applying three established neurotoxic regimens of METH: single high dose (1 × 30 mg/kg), multiple lower doses (3 × 5 mg/kg) or (3 × 10 mg/kg), we show that METH primarily damages type I fibers (the thinner ones), and to a much lesser extend types II-IV fibers including sterile axons...
June 22, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29934737/five-pointed-star-lattice-sutures-for-fixation-of-patella-transverse-fractures-a-clinical-study
#15
Xiaozheng Tang, Yayun Liu, Hongyan Wu, Feipeng Gong, Yuxu Li, Hong Zeng, Baofu Yu
INTRODUCTION: Fixation of displaced patella fractures with metal implants may be associated with implant failure, post-operative pain, and high re-operation rate. This study reports preliminary clinical results of using five-pointed star lattice sutures for the management of patella transverse fractures. METHODS: A five-pointed star lattice suture configuration was produced intraoperatively, and 25 patients with patella transverse fractures were treated with this newly designed sutures fixation...
June 22, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29934684/patient-reported-treatment-related-symptom-burden-for-patients-with-advanced-melanoma-in-canada
#16
Winson Y Cheung, Michelle K White, Martha S Bayliss, Angela Stroupe, Andrew Lovley, Bellinda L King-Kallimanis, Kathryn Lasch
BACKGROUND: Little is known on the impact of emerging treatments for advanced melanoma (stages III and IV) on patients' functioning and well-being. The objective of this study was to describe the patient-reported treatment-related symptom (TRS) burden in advanced melanoma. METHOD: Twenty-nine in-depth, qualitative interviews were conducted among adult patients with advanced melanoma in Canada using a semi-structured interview method. Interviews were transcribed verbatim, and key concepts were identified using a grounded theory analytic approach...
June 23, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29934273/impact-of-trauma-center-designation-and-interfacility-transfer-on-renal-trauma-outcomes-evidence-for-universal-management
#17
Marc A Bjurlin, Audrey Renson, Richard Jacob Fantus, Richard Joseph Fantus
BACKGROUND: Renal trauma may be managed differently in tiered trauma systems and among those who requireinterfaculty transfer. OBJECTIVE: To evaluate the initial management of renal trauma, assess patterns of management based on hospital trauma level designation and interfacility transfer status, and analyze management trends over time. DESIGN, SETTING, AND PARTICIPANTS: Retrospective cohort study of renal trauma from the National Trauma Data Bank 2010-2015...
June 19, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29934093/separation-of-neptunium-iv-from-actinides-by-solid-phase-extraction-using-a-resin-containing-aliquat-336
#18
Bholanath Mahanty, Arunasis Bhattacharyya, Prasanta Kumar Mohapatra
An extraction chromatographic resin material containing Aliquat 336 as the liquid anion exchanger extractant and Chromosorb W as the solid support was prepared and tested for the uptake of UO2 2+ , Np4+ , Pu4+ , and Pu3+ from nitric acid feed solutions. The resin beads were characterized by thermogravimetry/differential thermogravimetry (TG/DTG) and scanning electron microscopy (SEM) surface morphology analysis. The uptake trend for the metal ions from 3 M HNO3 was found to be Pu4+ > Np4+ > UO2 2+ > Pu3+ which clearly followed the trend of their ionic potentials...
June 15, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29934088/scapular-stabilization-limits-glenohumeral-stretching-in-children-with-brachial-plexus-injuries
#19
Stephanie A Russo, Carolyn M Killelea, Dan A Zlotolow, Scott H Kozin, Luisa M Rodriguez, Ross S Chafetz, James G Richards
PURPOSE: To quantify the effects of scapular stabilization on scapulothoracic and glenohumeral (GH) stretching. METHODS: Motion capture data during external rotation and abduction with and without scapular stabilization were collected and analyzed for 26 children with brachial plexus birth palsy. These positions were performed by an experienced occupational therapist and by the child's caretaker. Scapulothoracic and GH joint angular displacements were compared between stretches with no stabilization, stabilization performed by the therapist, and stabilization performed by the caretaker...
June 19, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29934085/thumb-opposition-recovery-following-surgery-for-severe-carpal-tunnel-syndrome-a-clinical-radiological-and-electrophysiological-pilot-study
#20
Bhavuk Garg, Vikrant Manhas, Anand Vardhan, Deep Narayan Srivastava, Chandan J Das, Deepti Vibha, Vivek Gupta, Rajesh Malhotra, Prakash Kotwal
PURPOSE: To objectively assess recovery of thumb opposition in patients with carpal tunnel syndrome (CTS) after open carpal tunnel release and to evaluate electrophysiological and magnetic resonance (MR) neurography findings as predictors of thumb opposition recovery. METHODS: A total of 22 patients with severe CTS and thenar atrophy were included in this study. A detailed clinical, electrophysiological, and MR neurography evaluation was done both before and after surgery at 6 months to assess thumb opposition recovery...
June 19, 2018: Journal of Hand Surgery
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