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https://www.readbyqxmd.com/read/28330066/endolymphatic-hydrops-imaging-why-oving-from-semi-quantitative-to-anatomical-based-evaluation
#1
Michael Eliezer, Irène Tropres, Alexandre Krainik, Arnaud Attye
INTRODUCTION: Recently, the semi-quantitative ratio grading for endolymphatic hydrops (EH) was found as none specific of MD because all healthy subjects referred with at least one hydrops location with this grading method and 3D-FLAIR sequence. The objectives of this study were to assess the EH prevalence in MD using both the semi-quantitative ratio method of grading and the Saccule to Utricle Ration Inversion (SURI) technique with two 3D-FLAIR sequences, closely similar except for the inversion time of the sequence...
March 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28329364/the-effect-of-different-mitral-annuloplasty-rings-on-valve-geometry-and-annular-stress-distribution%C3%A2
#2
Søren Nielsen Skov, Diana Mathilde Røpcke, Marcell Juan Tjørnild, Christine Ilkjær, Jonas Rasmussen, Hans Nygaard, Morten Olgaard Jensen, Sten Lyager Nielsen
OBJECTIVES: To characterize the remodelling effects and deformational forces of normosized rigid, semirigid and flexible mitral annuloplasty rings after implantation in healthy pigs. METHODS: Measurements were performed in vivo with 80-kg porcine animals. Twenty-eight animals were randomized into a no ring group, a flexible ring group (Duran AnCore Ring, Medtronic, Minneapolis, MN, USA), a rigid ring group (Carpentier-Edwards Classic annuloplasty ring, Edwards Lifesciences, Irvine, CA, USA) and a semirigid ring group (Carpentier-Edwards Physio I annuloplasty ring, Edwards Lifesciences)...
February 16, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28329299/rational-and-design-of-eurocrt-an-international-observational-study-on-multi-modality-imaging-and-cardiac-resynchronization-therapy
#3
Erwan Donal, Victoria Delgado, Julien Magne, Chiara Bucciarelli-Ducci, Christophe Leclercq, Bernard Cosyns, Marta Sitges, Thor Edvardsen, Elif Sade, Ivan Stankovic, Eustachio Agricola, Maurizio Galderisi, Patrizio Lancellotti, Alfredo Hernandez, Sven Plein, Denisa Muraru, Ehud Schwammenthal, Gerhard Hindricks, Bogdan A Popescu, Gilbert Habib
Aims: Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several observational studies have explored the role of imaging-derived LV dyssynchrony parameters to predict the response to CRT, but have yielded inconsistent results, precluding the inclusion of imaging-derived LV dyssynchrony parameters in current guidelines for selection of patients for CRT. METHODS: The EuroCRT is a large European multicentre prospective observational study led by the European Association of Cardiovascular Imaging...
February 27, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28328213/reversible-coordination-of-boron-aluminum-zinc-magnesium-and-calcium-hydrogen-bonds-to-bent-cul2-fragments-heavy-%C3%AF-complexes-of-the-lightest-coinage-metal
#4
Alexandra Hicken, Andrew J P White, Mark R Crimmin
A series of copper(I) complexes bearing electron-deficient β-diketiminate ligands have been prepared. The study includes [{{ArNC(CR3)}2CH}Cu(η(2)-toluene)n] (Ar = Mes, R = F, n = 0.5, [12·tol]; Ar = C6F5, R = Me, n = 1, [2·tol]; Ar = 2,6-Cl2C6H3, R = H, n = 0.5, [32·tol]). Reactions of [1-3n·tol] with boranes, alanes, a zinc hydride, a magnesium hydride, and a calcium hydride generate the corresponding σ complexes ([1-3·B], [3·B'], [3·Al], [3·Al'], [1-3·Zn], [1·Mg], and [1·Ca]). These species all form reversibly, being in equilibrium with the arene solvates in solution...
March 22, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28328111/light-controlled-release-and-uptake-of-zinc-ions-in-solution-by-a-photochromic-terthiazole-based-ligand
#5
Juliette Guérin, Anne Léaustic, Jérôme Berthet, Rémi Métivier, Régis Guillot, Stéphanie Delbaere, Keitaro Nakatani, Pei Yu
We have synthesized and fully characterized a photochromic zinc complex with a terphenylthiazole-based ligand with a salen-like cavity. The solution stability of the complex was found to be greatly dependent on the state of the photochromic ligand and an interesting photo-triggered release and uptake of zinc ions was found as well as monitored by its fluorescence. The contrasting stability difference of the zinc complex between its two isomeric states was rationalized by DFT calculations.
March 22, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28328095/haca-s-heritage-a-free-radical-pathway-to-phenanthrene-in-circumstellar-envelopes-of-asymptotic-giant-branch-stars
#6
Tao Yang, Ralf I Kaiser, Tyler P Troy, Bo Xu, Oleg Kostko, Musahid Ahmed, Alexander M Mebel, Marsel V Zagidullin, Valeriy N Azyazov
The hydrogen-abstraction/acetylene-addition (HACA) mechanism has been central for the last decades in attempting to rationalize the formation of polycyclic aromatic hydrocarbons (PAHs) as detected in carbonaceous meteorites such as in Murchison. Nevertheless, the basic reaction mechanisms leading to the formation of even the simplest tricyclic PAHs like anthracene and phenanthrene are still elusive. Here, by exploring the previously unknown chemistry of the ortho-biphenylyl radical with acetylene, we deliver compelling evidence on the efficient synthesis of phenanthrene in carbon-rich circumstellar environments...
March 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28328094/asthma-management-a-new-phenotype-based-approach-using-presence-of-eosinophilia-and-allergy
#7
REVIEW
Milan Terl, Vratislav Sedlák, Petr Cap, Renata Dvořáková, Viktor Kašák, Tomáš Kočí, Bronislava Novotna, Ester Seberova, Petr Panzner, Vladimir Zindr
Asthma is a heterogeneous disease. The Czech Pneumology and Allergology Societies commissioned 10 experts to review the literature and create joint national guidelines for managing asthma, reflecting this heterogeneity. The aim was to develop an easy-to-use diagnostic strategy as a rational approach to the widening opportunities for the use of phenotype-targeted therapy. The guidelines were presented on websites for public comments by members of both the societies. The reviewers' comments contributed to creating the final version of the guidelines...
March 22, 2017: Allergy
https://www.readbyqxmd.com/read/28327905/phase-ii-study-of-idelalisib-a-selective-inhibitor-of-pi3k%C3%AE-for-relapsed-refractory-classical-hodgkin-lymphoma
#8
A K Gopal, M A Fanale, C H Moskowitz, A R Shustov, S Mitra, W Ye, A Younes, A J Moskowitz
Background: The phosphatidylinositol-3-kinase delta (PI3Kδ) inhibitor idelalisib has been shown to block downstream intracellular signaling, reduce the production of prosurvival chemokines and induce apoptosis in classical Hodgkin lymphoma (HL) cell lines. It has also been shown to inhibit regulatory T cells and myeloid-derived suppressor cells in other tumor models. We hypothesized that inhibiting PI3Kδ would have both direct and indirect antitumor effects by directly targeting the malignant cells as well as modulating the inflammatory microenvironment...
January 24, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28327599/metal-organic-framework-templated-synthesis-of-ultrasmall-catalyst-loaded-zno-znco2o4-hollow-spheres-for-enhanced-gas-sensing-properties
#9
Won-Tae Koo, Seon-Jin Choi, Ji-Soo Jang, Il-Doo Kim
To achieve the rational design of nanostructures for superior gas sensors, the ultrasmall nanoparticles (NPs) loaded on ternary metal oxide (TMO) hollow spheres (HS) were synthesized by using the polystyrene (PS) sphere template and bimetallic metal-organic framework (BM-MOFs) mold. The zinc and cobalt based zeolite imidazole frameworks (BM-ZIFs) encapsulating ultrasmall Pd NPs (2-3 nm) were assembled on PS spheres at room temperature. After calcination at 450 °C, these nanoscale Pd particles were effectively infiltrated on the surface of ZnO/ZnCo2O4 HSs...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327460/comprehensive-proteomic-characterization-of-stem-cell-derived-extracellular-matrices
#10
Héloïse Ragelle, Alexandra Naba, Benjamin L Larson, Fangheng Zhou, Miralem Prijić, Charles A Whittaker, Amanda Del Rosario, Robert Langer, Richard O Hynes, Daniel G Anderson
In the stem-cell niche, the extracellular matrix (ECM) serves as a structural support that additionally provides stem cells with signals that contribute to the regulation of stem-cell function, via reciprocal interactions between cells and components of the ECM. Recently, cell-derived ECMs have emerged as in vitro cell culture substrates to better recapitulate the native stem-cell microenvironment outside the body. Significant changes in cell number, morphology and function have been observed when mesenchymal stem cells (MSC) were cultured on ECM substrates as compared to standard tissue-culture polystyrene (TCPS)...
March 7, 2017: Biomaterials
https://www.readbyqxmd.com/read/28327306/design-synthesis-antibacterial-activity-and-docking-study-of-some-new-trimethoprim-derivatives
#11
Umer Rashid, Waqas Ahmad, Syed Fahad Hassan, Naveeda Akhtar Qureshi, Basit Niaz, Bakhtiar Muhammad, Sameera Imdad, Muhammad Sajid
In present study, nineteen novel trimethoprim (TMP) derivatives were designed, synthesized and evaluated for their antibacterial potential. Hydroxy trimethoprim 2 (HTMP) was synthesized by following the demethylation of 4-methoxy group at trimethoxy benzyl ring of TMP. Structure-activity relationship (SAR) studies were explored on HTMP by incorporating various substituents leading to the identification of some new compounds with improved antibacterial activities. The results revealed that the introduction of benzyloxy (4a-e) and phenyl ethanone (5a-e) group at 4-position of dimethoxy benzyl ring leads to overall increase in the antibacterial activity...
December 1, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28327225/accurate-perceptions-do-not-need-complete-information-to-reflect-reality
#12
Shabnam Mousavi, David C Funder
Social reality of a group emerges from interpersonal perceptions and beliefs put to action under a host of environmental conditions. By extending the study of fast-and-frugal heuristics, we view social perceptions as judgment tools and assert that perceptions are ecologically rational to the degree that they adapt to the social reality. We maintain that the veracity of both stereotypes and base rates, as judgment tools, can be determined solely by accuracy research.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28327218/an-evolutionary-approach-to-accuracy-in-social-perception
#13
Anthony C Little
An evolutionary approach highlights that accuracy should be expected over error because selection pressures will have shaped social perception to be functional. Behaviour is extremely complex and so it is unlikely that observers will be perfectly accurate, but an evolutionary view strongly predicts that people will behave as rational observers and in many cases social perception should favour adaptive responses.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28327216/the-expressive-rationality-of-inaccurate-perceptions
#14
Dan M Kahan
This commentary uses the dynamic of identity-protective cognition to pose a friendly challenge to Jussim (2012). Like other forms of information processing, this one is too readily characterized as a bias. It is no mistake, however, to view identity-protective cognition as generating inaccurate perceptions. The "bounded rationality" paradigm incorrectly equates rationality with forming accurate beliefs. But so does Jussim's critique.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28327213/are-stereotypes-accurate-a-perspective-from-the-cognitive-science-of-concepts
#15
Lin Bian, Andrei Cimpian
In his 2012 book, Jussim suggests that people's beliefs about various groups (i.e., their stereotypes) are largely accurate. We unpack this claim using the distinction between generic and statistical beliefs - a distinction supported by extensive evidence in cognitive psychology, linguistics, and philosophy. Regardless of whether one understands stereotypes as generic or statistical beliefs about groups, skepticism remains about the rationality of social judgments.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28327212/more-stereotypes-please-the-limits-of-theory-of-mind-and-the-need-for-further-studies-on-the-complexity-of-real-world-social-interactions
#16
Kristin Andrews
I suggest that the Stereotype Rationality Hypothesis (Jussim 2012) is only partially right. I agree it is rational to rely on stereotypes, but in the complexity of real world social interactions, most of our individuating information invokes additional stereotypes. Despite assumptions to the contrary, there is reason to think theory of mind is not accurate, and social psychology's denial of stereotype accuracy led us toward mindreading/theory of mind - a less accurate account of how we understand other people...
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28326779/illuminating-photochemistry-of-an-excitation-ratiometric-fluorescent-protein-calcium-biosensor
#17
Longteng Tang, Yanli Wang, Weimin Liu, Yongxin Zhao, Robert E Campbell, Chong Fang
Fluorescent protein (FP) based biosensors have become an important and promising tool to track metal ion movement inside living systems. Their working principles after light irradiation, however, remain elusive. To facilitate the rational design of biosensors, we dissect the fluorescence modulation mechanism of a newly developed excitation ratiometric green FP-based Ca(2+) biosensor, GEX-GECO1, using femtosecond stimulated Raman spectroscopy (FSRS) in the electronic excited state. Upon 400 nm photoexcitation, characteristic vibrational marker bands at ~1180 and 1300 cm(-1) show concomitant decay and rise dynamics, probing the progression of an ultrafast excited state proton transfer (ESPT) reaction...
March 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28326678/rational-engineering-of-bodipy-bridged-trisindole-derivatives-for-solar-cell-applications
#18
Nicolas Leclerc, Ibrahim Bulut, Quentin Huaulmé, Antoine Mirloup, Patricia Chávez, Sadiara Fall, Anne Hébraud, Stéphane Méry, Benoit Heinrich, Thomas Heiser, Patrick Lévêque
Boron dipyrromethene (Bodipy) are known to be efficient photon harvesting chromophores. However, their study as active materials in bulk heterojunction (BHJ) solar cells is still scarce. In this paper, we developed new synthetic ways to design original Bodipy-based dumbbell-shape molecules, including a first 2,3,5,6-tetravinyl aromatic Bodipy molecule. We demonstrated that high fill factors can be obtained in BHJ solar cells when blended with a fullerene derivative, leading to a new Bodipy-based record power conversion efficiency of 5...
March 21, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28326659/strings-of-porous-carbon-polyhedrons-as-self-standing-cathode-host-for-high-energy-density-lithium-sulfur-batteries
#19
Yazhi Liu, Gaoran Li, Jing Fu, Zhongwei Chen, Xinsheng Peng
Rational design of cathode hosts with high electrical conductivity and strong sulfur confinement is a great need for high-performance lithium-sulfur batteries. Herein, we report a self-standing, hybrid-nanostructured cathode host comprised of metal-organic framework (MOF)-derived porous carbon polyhedrons and carbon nanotubes (CNTs) for the significant improvement of both the electrode cyclability and energy density. The strong coupling of the intertwined CNTs and strung porous carbon polyhedrons as a binder-free thin film significantly enhances the long-range electronic conductivity and provides abundant active interfaces as well as robust electrode integrity for sulfur electrochemistry...
March 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28326287/safe-sex-self-efficacy-and-safe-sex-practice-in-a-southern-united-states-college
#20
Ovuokerie Addoh, Eveleen Sng, Paul D Loprinzi
Background: The purpose of this study was to assess the association between safe sex self-efficacy and safe-sex practice in a Southern college setting. Methods: Multivariable logistic regression models were used to examine the association between safe sex self-efficacy in four domains (mechanics, partner disapproval, assertiveness, intoxicants) and safe sex practice (outcome variable). Results: For every 1-unit increase in the composite condom use self-efficacy score, there was an 8% increase in the odds of being beyond the median safe-sex practice score (odds ration [OR]: 1...
2017: Health Promotion Perspectives
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