keyword
MENU ▼
Read by QxMD icon Read
search

Rationing

keyword
https://www.readbyqxmd.com/read/29244525/20-year-outcomes-of-anterior-cruciate-ligament-reconstruction-with-hamstring-tendon-autograft-the-catastrophic-effect-of-age-and-posterior-tibial-slope
#1
Lucy J Salmon, Emma Heath, Hawar Akrawi, Justin P Roe, James Linklater, Leo A Pinczewski
BACKGROUND: No well-controlled studies have compared the long-term outcome of anterior cruciate ligament (ACL) reconstruction with hamstring tendon autograft between adolescents and adults. Increased posterior tibial slopes (PTSs) have been reported in the ACL-injured versus controls, but the effect of PTS on the outcome after reconstruction is relatively unexplored. PURPOSE: To compare the prospective longitudinal outcome of "isolated" ACL ruptures treated with anatomic endoscopic ACL reconstruction using hamstring tendon autograft over 20 years in adolescent and adult cohorts and to examine factors for repeat ACL injury...
December 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29244479/discovery-of-intermetallic-compounds-from-traditional-to-machine-learning-approaches
#2
Anton O Oliynyk, Arthur Mar
Intermetallic compounds are bestowed by diverse compositions, complex structures, and useful properties for many materials applications. How metallic elements react to form these compounds and what structures they adopt remain challenging questions that defy predictability. Traditional approaches offer some rational strategies to prepare specific classes of intermetallics, such as targeting members within a modular homologous series, manipulating building blocks to assemble new structures, and filling interstitial sites to create stuffed variants...
December 15, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29244207/information-about-expert-decision-and-post-decision-distortion-of-facts-of-own-decision
#3
Ola Svenson, Nichel Gonzalez, Amina Memon, Torun Lindholm
Cognitive representations of decision problems are dynamic. During and after a decision, evaluations and representations of facts change to support the decision made by a decision maker her- or himself (Svenson, 2003). We investigated post-decision distortion of facts (consolidation). Participants were given vignettes with facts about two terminally ill patients, only one of whom could be given lifesaving surgery. In Study 1, contrary to the prediction, the results showed that facts were distorted after a decision both by participants who were responsible for the decisions themselves and when doctors had made the decision...
December 15, 2017: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/29243991/zoonotic-agents-in-feral-pigeons-columba-livia-from-costa-rica-possible-improvements-to-diminish-contagion-risks
#4
Ana María Torres-Mejía, César Rodríguez, Francisco Duarte, Mauricio Jiménez-Soto, Fernando Esperón, Kinndle Blanco-Peña
Most studies on zoonotic agents in pigeons have been conducted in the Palearctic region, but the scarcity of data is notorious in the Neotropical region, where these birds can breed all year around and are in close contact with humans. In this study, we used a combination of culture-dependent and culture-independent methods to identify infectious agents in 141 fecal samples from pigeons collected at four urban parks from Costa Rica. Of these we identified 34 positive samples for Salmonella enterica subsp. enterica serovar Braenderup (24...
December 15, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29243947/multiple-target-based-pharmacophore-design-from-active-site-structures
#5
P Kumar, R Kaalia, A Srinivasan, I Ghosh
Health care systems have benefitted from rational drug discovery processes like vHTS, virtual high throughput screening pharmacophores and quantitative structure-activity relationships, and many challenges have been explored using such techniques: decisions on specificity and selectivity are made after screening millions of molecules for multiple targets. Recent challenges in drug research emphasize the design of drugs that bind with more than one target of interest (multi-target) and do not bind with undesirable targets...
December 15, 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/29243930/structure-based-kinase-profiling-to-understand-the-polypharmacological-behavior-of-therapeutic-molecules
#6
Devawati Dutta, Ranjita Das, Chhabinath Mandal, Chitra Mandal
Several drugs elicit their therapeutic efficacy by modulating multiple cellular targets and possess varied polypharmacological actions. The identification of the molecular targets of a potent bioactive molecule is essential in determining its overall polypharmacological profile. Experimental procedures are expensive and time-consuming. Therefore, computational approaches are actively implemented in rational drug discovery. Here, we demonstrate a computational pipeline, based on reverse virtual screening technique using several consensus scoring strategies, and perform structure-based kinase profiling of 12 FDA-approved drugs...
December 15, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29243885/first-end-deck-cyclo-p4-fe-complex-synthesis-and-reactivity
#7
Anthony Cavaillé, Nathalie Saffon-Merceron, Noel Nebra, Marie Fustier-Boutignon, Nicolas Mézailles
Reduction of the FeII complex [(PhPP2Cy)FeCl2] (2) generates an electron rich and unsaturated Fe0 which is reacted with white phosphorus. The new complex obtained, [(PhPP2Cy)Fe(η4-P4)] (3), is the first iron cyclo-P4 complex and the only known stable end deck cyclo-P4 complex outside of group V. Complex 3 bears a FeII center as shown by Mössbauer spectroscopy, associated to a P42- fragment. Analysis of the molecular orbitals rationalizes the distinct reactivity of complex 3. Reaction of complex 3 with H+ affords the unstable complex [(PhPP2Cy)Fe(η4-P4)(H)]+ (4), whereas with CuCl and BCF the complexes [(PhPP2Cy)Fe(η4:η1-P4)(μ-CuCl)]2 (5) and [(PhPP2Cy)Fe(η4:η1-P4)B(C6F5)3] (6) are formed...
December 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29243783/research-on-the-nutrition-and-cognition-of-high-risk-stroke-groups-in-community-and-the-relevant-factors
#8
N-N Zhao, K-X Zeng, Y-L Wang, P-J Sheng, C-Z Tang, P Xiao, X-W Liu
OBJECTIVE: To investigate the prevalence rate of nutritional risk in high-risk stroke groups in community, analyze its influencing factors, and analyze and compare the relationship between nutritional risk or malnutrition assessed by different nutritional evaluation methods and cognitive function, so as to provide the basis and guidance for clinical nutritional assessment and support. PATIENTS AND METHODS: A cross-sectional survey was performed for 1196 cases in high-risk stroke groups in community from December 2015 to January 2017...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243480/reshaping-the-energy-landscape-transforms-the-mechanism-and-binding-kinetics-of-dna-threading-intercalation
#9
Andrew G Clark, M Nabuan Naufer, Fredrik Westerlund, Per Lincoln, Ioulia Rouzina, Thayaparan Paramanathan, Mark C Williams
Molecules that bind DNA via threading intercalation show high binding affinity as well as slow dissociation kinetics, properties ideal for the development of anticancer drugs. To this end, it is critical to identify the specific molecular characteristics of threading intercalators that result in optimal DNA interactions. Using single molecule techniques, we quantify the binding of a small metalorganic ruthenium threading intercalator (Δ,Δ-B), and compare its binding characteristics to a similar molecule with significantly larger threading moieties (Δ,Δ-P)...
December 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/29243418/-research-progress-of-pharmacokinetics-and-pharmacodynamics-of-total-glucosides-of-peony-in-hepatoprotective-effects
#10
REVIEW
Zhi-Yan Zuo, Shu-Yu Zhan, Xuan Huang, Bao-Yue Ding, Yu-Qian Liu, Yu-Er Ruan, Ning-Hua Jiang
Total glucosides of peony (TGP), containing the effective components of paeoniflorin (Pae), albiflorin (Alb) and so on, are effective parts of Radix Paeoniae Alba. And it possesses extensive pharmacological actions, one of which is hepatoprotective effect. In recent years, abundant of pharmacokinetics and pharmacodynamics research of TGP in hepatoprotective effects have been performed. However, the relative medicine of TGP in hepatoprotective effect has not been developed for clinical application. In order to provide reference for the development and rational clinical application of TGP, the research progresses of pharmacokinetics and pharmacodynamics of TGP in hepatoprotective effect were summarized in this paper...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29243094/hierarchical-design-of-artificial-proteins-and-complexes-toward-synthetic-structural-biology
#11
REVIEW
Ryoichi Arai
In multiscale structural biology, synthetic approaches are important to demonstrate biophysical principles and mechanisms underlying the structure, function, and action of bio-nanomachines. A central goal of "synthetic structural biology" is the design and construction of artificial proteins and protein complexes as desired. In this paper, I review recent remarkable progress of an array of approaches for hierarchical design of artificial proteins and complexes that signpost the path forward toward synthetic structural biology as an emerging interdisciplinary field...
December 14, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/29242831/novel-concepts-for-hiv-vaccine-vector-design
#12
REVIEW
Quazim A Alayo, Nicholas M Provine, Pablo Penaloza-MacMaster
The unprecedented challenges of developing effective vaccines against intracellular pathogens such as HIV, malaria, and tuberculosis have resulted in more rational approaches to vaccine development. Apart from the recent advances in the design and selection of improved epitopes and adjuvants, there are also ongoing efforts to optimize delivery platforms. Viral vectors are the best-characterized delivery tools because of their intrinsic adjuvant capability, unique cellular tropism, and ability to trigger robust adaptive immune responses...
November 2017: MSphere
https://www.readbyqxmd.com/read/29242604/ribosomal-protein-s15a-promotes-tumor-angiogenesis-via-enhancing-wnt-%C3%AE-catenin-induced-fgf18-expression-in-hepatocellular-carcinoma
#13
Pengyi Guo, Yi Wang, Chunxiu Dai, Chonglin Tao, Fang Wu, Xiaozai Xie, Haitao Yu, Qiandong Zhu, Junjian Li, Longyun Ye, Fuxiang Yu, Yunfeng Shan, Zhengping Yu, Renumathy Dhanasekaran, Rongyuan Zheng, Gang Chen
Ribosomal protein s15a (RPS15A) plays a promotive role in the mRNA/ribosome interactions during early translation. Our previous study has found that inhibiting RPS15A expression can decrease proliferation and induce cell cycle arrest in hepatocellular carcinoma (HCC) cell lines. However, the mechanism underlying the involvement of RPS15A in HCC pathogenesis and the clinical significance of RPS15A expression remain unclear. In this study, an evaluation of RPS15A expression in 110 surgically resected HCCs and matched tumor-adjacent normal tissues revealed an overexpression of RPS15A in HCC, which was correlated with worse survival...
December 15, 2017: Oncogene
https://www.readbyqxmd.com/read/29242588/in-retinitis-pigmentosa-trkc-t1-dependent-vectorial-erk-activity-upregulates-glial-tnf-%C3%AE-causing-selective-neuronal-death
#14
Alba Galán, Sean Jmaeff, Pablo F Barcelona, Fouad Brahimi, Marinko V Sarunic, H Uri Saragovi
In some diseases the TrkC.T1 isoform is upregulated in glia, associated with glial TNF-α production and neuronal death. What remains unknown are the activating signals in glia, and how paracrine signals may be selective for a targeted neuron while sparing other proximate neurons. We studied these questions in the retina, where Müller glia contacts photoreceptors on one side and retinal ganglion cells on the other. In a mutant Rhodopsin mouse model of retinitis pigmentosa (RP) causing progressive photoreceptor death-but sparing retinal ganglion cells-TrkC...
December 14, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29242347/comprehensive-computational-design-of-ordered-peptide-macrocycles
#15
Parisa Hosseinzadeh, Gaurav Bhardwaj, Vikram Khipple Mulligan, Matthew D Shortridge, Timothy W Craven, Fátima Pardo-Avila, Stephen A Rettie, David E Kim, Daniel-Adriano Silva, Yehia M Ibrahim, Ian K Webb, John R Cort, Joshua N Adkins, Gabriele Varani, David Baker
Mixed-chirality peptide macrocycles such as cyclosporine are among the most potent therapeutics identified to date, but there is currently no way to systematically search the structural space spanned by such compounds. Natural proteins do not provide a useful guide: Peptide macrocycles lack regular secondary structures and hydrophobic cores, and can contain local structures not accessible with l-amino acids. Here, we enumerate the stable structures that can be adopted by macrocyclic peptides composed of l- and d-amino acids by near-exhaustive backbone sampling followed by sequence design and energy landscape calculations...
December 15, 2017: Science
https://www.readbyqxmd.com/read/29242049/rational-library-design-by-functional-cdr-resampling
#16
Qi Zhao, Diane Buhr, Courtney Gunter, Jenny Frenette, Mary Ferguson, Eric Sanford, Erika Holland, Chitra Rajagopal, Melissa Batonick, Margaret M Kiss, Michael P Weiner
Successful antibody discovery relies on diversified libraries, where two aspects are implied, namely the absolute number of unique clones and the percentage of functional clones. Instead of pursuing the absolute quantity thresholded by current display technology, we have sought to maximize the effective diversity by improving functional clone percentage. With the combined effort of bioinformatics, structural biology, molecular immunology and phage display technology, we devised a bioinformatic pipeline to construct and validate libraries via combinatorial assembly of sequences from a database of experimentally validated antibodies...
December 11, 2017: New Biotechnology
https://www.readbyqxmd.com/read/29241971/blocking-stemness-and-metastatic-properties-of-ovarian-cancer-cells-by-targeting-p70s6k-with-dendrimer-nanovector-based-sirna-delivery
#17
Jing Ma, Shashwati Kala, Susan Yung, Tak Mao Chan, Yu Cao, Yifan Jiang, Xiaoxuan Liu, Suzanne Giorgio, Ling Peng, Alice S T Wong
Metastasis is the cause of most (>90%) cancer deaths and currently lacks effective treatments. Approaches to understanding the biological process, unraveling the most effective molecular target(s), and implementing nanotechnology to increase the therapeutic index are expected to facilitate cancer therapy against metastasis. Here, we demonstrate the potential advantages of bringing these three approaches together through the rational design of a small interfering RNA (siRNA) that targets p70S6K in cancer stem cells (CSCs) in combination with dendrimer nanotechnology-based siRNA delivery...
November 16, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29241812/exploiting-the-therapeutic-potential-of-ready-to-use-drugs-repurposing-antibiotics-against-amyloid-aggregation-in-neurodegenerative-diseases
#18
REVIEW
Sergio B Socias, Florencia Gonzalez-Lizarraga, Cesar L Avila, Cecilia Vera, Leonardo Acuña, Julia E Sepulveda-Diaz, Elaine Del-Bel, Rita Raisman-Vozari, Rosana N Chehin
Neurodegenerative diseases are chronic and progressive disorders that affect specific regions of the brain, causing gradual disability and suffering that results in a complete inability of patients to perform daily functions. Amyloid aggregation of specific proteins is the most common biological event that is responsible for neuronal death and neurodegeneration in various neurodegenerative diseases. Therapeutic agents capable of interfering with the abnormal aggregation are required, but traditional drug discovery has fallen short...
December 11, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/29241708/contribution-of-cb1rs-in-anxiety-related-behaviors-but-not-locomotor-deficits-induced-by-methamphetamine
#19
Effat Ramshini, Gholamreza Sepehri, Meysam Ahmadi-Zeidabadi, Shokouh Arjmand, Mohammad Khaksari, Mohammad Shabani
Several lines of evidence have indicated that Methamphetamine (METH) exposure leads to neurodegenerative changes in the dopaminergic neurons and subsequently may predispose users to motor deficit. On the other hand, there is a reciprocal regulation between the endocannabinoid and the dopaminergic systems. Previous studies also showed that the endocannabinoids are involved in the signaling mechanisms of various brain regions related to motor and cognitive functions. The cerebellum seems as a rational target to investigate the action of cannabinoids on motor coordination because of the high concentration of the cannabinoid receptor in the molecular layer of it and other regions involved in motor activity...
December 11, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29241362/simplified-teixobactin-analogues-to-target-superbugs
#20
Ishwar Singh
Ishwar Singh speaks to Benjamin Walden, Commissioning Editor. Ishwar Singh is a Senior Lecturer in biological chemistry at the School of Pharmacy, University of Lincoln. Prior to Lincoln, he had held many prestigious fellowships such as the Alexander von Humboldt fellowship, Germany; and Senior Research Fellowship, DANIDA, Denmark and CSIR, India. He is an organic chemist. He has developed bioconjugations for DNA, RNA and polymer modifications. He is currently leading research in novel antimicrobials based on rational design against clinically important resistant bacteria (such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, mycobacteria, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa), biologics delivery, peptides, sequence-selective DNA cross linking, nanoparticles modifications for drug delivery and diagnostic applications...
December 15, 2017: Future Medicinal Chemistry
keyword
keyword
38105
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"