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https://www.readbyqxmd.com/read/28550477/iodinated-contrast-agents-in-patients-with-myasthenia-gravis-a-retrospective-cohort-study
#1
Jakob Rath, Matthias Mauritz, Gudrun Zulehner, Eva Hilger, Hakan Cetin, Gregor Kasprian, Eduard Auff, Fritz Zimprich
Currently, it has not been satisfactorily established, whether modern low-osmolality iodinated contrast agents (ICAs) used in computed tomography (CT) studies are a risk factor for exacerbation of myasthenic symptoms. The rate of acute adverse events as well as delayed clinical worsening up to 30 days were analyzed in 73 patients with confirmed myasthenia gravis (MG) who underwent contrast-enhanced CT studies and compared to 52 patients who underwent unenhanced CT studies. One acute adverse event was documented...
May 26, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28550472/salt-induced-na-k-atpase-%C3%AE-%C3%AE-expression-involves-soluble-adenylyl-cyclase-in-endothelial-cells
#2
Mirja Mewes, Johanna Nedele, Katrin Schelleckes, Olga Bondareva, Malte Lenders, Kristina Kusche-Vihrog, Hans-Joachim Schnittler, Stefan-Martin Brand, Boris Schmitz, Eva Brand
High dietary salt intake may lead to vascular stiffness, which predicts cardiovascular diseases such as heart failure, and myocardial and cerebral infarctions as well as renal impairment. The vascular endothelium is a primary target for deleterious salt effects leading to dysfunction and endothelial stiffness. We hypothesize that the Ca(2+)- and bicarbonate-activated soluble adenylyl cyclase (sAC) contributes to Na(+)/K(+)-ATPase expression regulation in vascular endothelial cells and is an important regulator of endothelial stiffness...
May 26, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28550182/recessive-grey-platelet-like-syndrome-with-unaffected-erythropoiesis-in-the-absence-of-the-splice-isoform-gfi1b-p37
#3
Harald Schulze, Axel Schlagenhauf, Georgi Manukjan, Christine Beham-Schmid, Oliver Andres, Eva Klopocki, Eva-Maria König, Harald Haidl, Simon Panzer, Karina Althaus, Wolfgang E Muntean, Wolfgang Schwinger, Christian Urban, Andreas Greinacher, Tamam Bakchoul, Markus G Seidel
No abstract text is available yet for this article.
May 26, 2017: Haematologica
https://www.readbyqxmd.com/read/28550123/essential-role-for-histone-deacetylase-11-hdac11-in-neutrophil-biology
#4
Eva Sahakian, Jie Chen, John J Powers, Xianghong Chen, Kamira Maharaj, Susan L Deng, Maritza Lienlaf, Hong Wei Wang, Fengdong Cheng, Andressa L Sodré, Allison Distler, Limin Xing, Patricio Perez-Villarroel, Sheng Wei, Alejandro Villagra, Ed Seto, Eduardo M Sotomayor, Pedro Horna, Javier Pinilla-Ibarz
Epigenetic changes in chromatin structure have been recently associated with the deregulated expression of critical genes in normal and malignant processes. HDAC11, the newest member of the HDAC family of enzymes, functions as a negative regulator of IL-10 expression in APCs, as previously described by our lab. However, at the present time, its role in other hematopoietic cells, specifically in neutrophils, has not been fully explored. In this report, for the first time, we present a novel physiologic role for HDAC11 as a multifaceted regulator of neutrophils...
May 26, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28549955/a-peculiar-case-of-type-1-endoleak-after-nellix-endovascular-aneurysm-sac-sealing-clinical-presentation-and-management
#5
O Martinelli, L Irace, R Gattuso, C Belli, M Fresilli, B Gossetti
We report one case of type 1 endoleak (EL) with an outflow via a lumbar artery following Nellix endovascular aneurysm sealing (EVAS) in order to discuss the specific peculiarities and management of this complication. A 64-year-old man ( ASA 3) underwent Nellix EVAS for an asymptomatic infra-renal aortic aneurysm. The 6-month Duplex scanning ultrasound and magnetic resonance imaging showed a type IA endoleak with an outflow via a lumbar artery (LA) combined with a stable aneurysmal sac size. The subsequent 9-month imaging controls showed no changes of the endoleak cavity but there was a slight enlargement in proximal neck size associated with the distal migration of both Nellix grafts...
May 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28549825/metabolic-integration-of-bacterial-endosymbionts-through-antimicrobial-peptides
#6
REVIEW
Peter Mergaert, Yoshitomo Kikuchi, Shuji Shigenobu, Eva C M Nowack
Antimicrobial peptides (AMPs) are massively produced by eukaryotic hosts during symbiotic interactions with bacteria. Among other roles, these symbiotic AMPs have the capacity to permeabilize symbiont membranes and facilitate metabolite flow across the host-symbiont interface. We propose that an ancestral role of these peptides is to facilitate metabolic exchange between the symbiotic partners through membrane permeabilization. This function may be particularly critical for integration of endosymbiont and host metabolism in interactions involving bacteria with strongly reduced genomes lacking most small metabolite transporters...
May 23, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/28549819/rivaroxaban-for-stroke-prevention-in-patients-with-nonvalvular-atrial-fibrillation-and-active-cancer
#7
Eva S Laube, Anthony Yu, Dipti Gupta, Yimei Miao, Patrick Samedy, Jonathan Wills, Stephen Harnicar, Gerald A Soff, Simon Mantha
Rivaroxaban is broadly used for the primary prevention of stroke and systemic embolism in the general population with nonvalvular atrial fibrillation (AF). However, there is little published evidence on the safety and efficacy of rivaroxaban for AF in patients with active cancer. The aim of this study was to assess the safety and efficacy of rivaroxaban in patients with active cancer and AF. The use of rivaroxaban in patients with cancer at the Memorial Sloan Kettering Cancer Center is monitored in the setting of a Quality Assessment Initiative...
April 27, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28549816/subtypes-of-stage-iv-ovarian-cancer-response-to-treatment-and-patterns-of-disease-recurrence
#8
Amy Jamieson, Peter Sykes, Lois Eva, Cecile Bergzoll, Bryony Simcock
BACKGROUND: To compare three different patterns of stage IV epithelial ovarian cancer; pleural effusion, parenchymal metastases and extra-abdominal lymph node metastases with treatment response and pattern of disease recurrence, and correlate treatment modality with outcome. METHODS: Retrospective analysis of FIGO stage IV epithelial ovarian cancer diagnosed between 2008 and 2012 in three gynaecologic oncology centres in New Zealand. RESULTS: 124 patients were analysed, 58 had pleural effusions, 38 parenchymal metastases, and 28 extra-abdominal lymph nodes...
May 23, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28549744/survival-after-resection-of-perihilar-cholangiocarcinoma-in%C3%A2-patients-with-lymph-node-metastases
#9
Stefan Buettner, Jeroen L A van Vugt, Marcia P Gaspersz, Robert J S Coelen, Eva Roos, Tim A Labeur, Georgios A Margonis, Cecilia G Ethun, Shishir K Maithel, George Poultsides, Thuy Tran, Kamran Idrees, Chelsea A Isom, Ryan C Fields, Bradley A Krasnick, Sharon M Weber, Ahmed Salem, Robert C G Martin, Charles R Scoggins, Perry Shen, Harveshp D Mogal, Carl Schmidt, Eliza Beal, Ioannis Hatzaras, Rivfka Shenoy, Jan N M IJzermans, Thomas M van Gulik, Timothy M Pawlik, Bas Groot Koerkamp
BACKGROUND: The aim of this study was to compare patients with PHC with lymph node metastases (LN+) who underwent a resection with patients who did not undergo resection because of locally advanced disease at exploratory laparotomy. METHODS: Consecutive LN+ patients who underwent a resection for PHC in 12 centers were compared with patients who did not undergo resection because of locally advanced disease at exploratory laparotomy in 2 centers. RESULTS: In the resected cohort of 119 patients, the median overall survival (OS) was 19 months and the estimated 1-, 3- and 5-year OS was 69%, 27% and 13%, respectively...
May 23, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28549687/toward-harmonization-of-interpretive-commenting-of-common-laboratory-tests
#10
REVIEW
Attila Bezzegh, Ildikó Takács, Éva Ajzner
Interpretive commenting (IC) is an integral part of postanalytical activities of laboratories when the clinical interpretation of laboratory results in the context of the clinical situation of a patient is provided. Harmonizing practices in IC can be an approach to ensure high-quality comments, which if followed by adequate clinical actions has a great potential in improving patient outcomes. This paper reviews basic work prior to harmonization of IC of common laboratory test results. Practices in IC are considerably diverse both within and between countries...
May 23, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28549636/amplitude-integrated-electroencephalography-improves-the-identification-of-infants-with-encephalopathy-for-therapeutic-hypothermia-and-predicts-neurodevelopmental-outcomes-at-2-years-of-age
#11
Janne Helen Skranes, Gro Løhaugen, Eva Margrethe Schumacher, Damjan Osredkar, Andres Server, Frances Mary Cowan, Tom Stiris, Drude Fugelseth, Marianne Thoresen
OBJECTIVES: To examine whether using an amplitude-integrated electroencephalography (aEEG) severity pattern as an entry criterion for therapeutic hypothermia better selects infants with hypoxic-ischemic encephalopathy and to assess the time-to-normal trace for aEEG and magnetic resonance imaging (MRI) lesion load as 24-month outcome predictors. STUDY DESIGN: Forty-seven infants meeting Norwegian therapeutic hypothermia guidelines were enrolled prospectively. Eight-channel EEG/aEEG was recorded from 6 hours until after rewarming, and read after discharge...
May 23, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28549360/-intercarpal-fusion-as-a-salvage-procedure-in-kienb%C3%A3-ck-disease
#12
M Puig-Zentella, J A Rivas-Montero, E Hernández-Méndez-Villamil, A J Espinosa-Gutiérrez
INTRODUCTION: Functional results of four surgical techniques to resolve the IIIB-IV Litchman's stage of the Kienböck disease were analyzed. We observed the evolution from 2000 to 2015. MATERIAL AND METHODS: Transversal retrospective study of 33 patients treated with different surgical techniques and evaluated with Quick-DASH scale, dynamometer and EVA. RESULTS: Less functional limitation was found in the patients who underwent the intercarpal fusion with or without neurotomy of the posterior interosseous...
November 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28549089/development-of-a-sustained-release-voriconazole-containing-thermogel-for-subconjunctival-injection-in-horses
#13
Rosemary S Cuming, Eva M Abarca, Sue Duran, Anne A Wooldridge, Allison J Stewart, William Ravis, R Jayachandra Babu, Yuh-Jing Lin, Terri Hathcock
Purpose: To determine in vitro release profiles, transcorneal permeation, and ocular injection characteristics of a voriconazole-containing thermogel suitable for injection into the subconjunctival space (SCS). Methods: In vitro release rate of voriconazole (0.3% and 1.5%) from poly (DL-lactide-co-glycolide-b-ethylene glycol-b-DL-lactide-co-glycolide) (PLGA-PEG-PLGA) thermogel was determined for 28 days. A Franz cell diffusion chamber was used to evaluate equine transcorneal and transscleral permeation of voriconazole (1...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28548662/erratum-enzyme-discovery-beyond-homology-a-unique-hydroxynitrile-lyase-in-the-bet-v1-superfamily
#14
Elisa Lanfranchi, Tea Pavkov-Keller, Eva-Maria Koehler, Matthias Diepold, Kerstin Steiner, Barbara Darnhofer, Jürgen Hartler, Tom Van Den Bergh, Henk-Jan Joosten, Mandana Gruber-Khadjawi, Gerhard G Thallinger, Ruth Birner-Gruenberger, Karl Gruber, Margit Winkler, Anton Glieder
This corrects the article DOI: 10.1038/srep46738.
May 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28548239/impact-of-barium-enema-on-acute-diverticulitis-recurrence-a-retrospective-cohort-study-of-349-patients
#15
Francisco J Medina-Fernández, Lidia Rodríguez-Ortiz, Dimas J Garcilazo-Arismendi, Elena Navarro-Rodríguez, Eva M Torres-Tordera, César A Díaz-López, Javier Briceño
AIM: Acute diverticulitis is becoming a health concern in western countries as its incidence is increasing. Currently, one of the accepted theories on possible causes of diverticular perforation is the impactation of faecal residuals into some diverticula. Our aim was to evaluate whether barium impactation might have a negative effect by promoting diverticular inflammation/rupture and thereby acute diverticulitis recurrence. METHODS: A retrospective cohort study (January 2005/December 2015) was conducted at the Reina Sofia University Hospital of Cordoba (Spain)...
May 26, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28548126/microrna-dysregulation-in-the-tumor-microenvironment-influences-the-phenotype-of-pancreatic-cancer
#16
Eva Karamitopoulou, Stefan Haemmig, Ulrich Baumgartner, Cornelia Schlup, Martin Wartenberg, Erik Vassella
Cellular interactions in the tumor microenvironment influence neoplastic progression in pancreatic ductal adenocarcinoma. One underlying mechanism is the induction of the prognostically unfavorable epithelial-mesenchymal-transition-like tumor budding. Our aim is to explore the expression of microRNAs implicated in the regulation of tumor budding focusing on the microenvironment of the invasive front. To this end, RNA from laser-capture-microdissected material of the main tumor, tumor buds, juxta-tumoral stroma, tumor-remote stroma, and non-neoplastic pancreatic parenchyma from pancreatic cancer cases with (n=7) and without (n=6) tumor budding was analyzed by qRT-PCR for the expression of a panel of miRNAs that are known to be implicated in the regulation of epithelial-mesenchymal transition, including miR-21, miR-183, miR-200b, miR-200c, miR-203, miR-205, miR-210, and miR-217...
May 26, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28547116/groove-binding-of-vanillin-and-ethyl-vanillin-to-calf-thymus-dna
#17
Kaixin Xia, Guowen Zhang, Song Li, Deming Gong
Vanillin (VAN) and ethyl vanillin (EVA) are widely used food additives as flavor enhancers, but may have a potential security risk. In this study, the properties of binding of VAN or EVA with calf thymus DNA (ctDNA) were characterized by multi-spectroscopic methods, multivariate curve resolution-alternating least-squares (MCR-ALS) algorithm and molecular simulation. The concentration profiles for the components (VAN or EVA, ctDNA and VAN-ctDNA or EVA-ctDNA complex) by the MCR-ALS analysis showed that VAN or EVA interacted with ctDNA and formed VAN-ctDNA or EVA-ctDNA complex...
May 25, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28546893/btex-detection-with-composites-of-ethylenevinyl-acetate-and-nanostructured-carbon
#18
Santa Stepina, Astrida Berzina, Gita Sakale, Maris Knite
By using a solvent-based method composites of ethylenevinyl acetate copolymer and carbon black (EVA-CB) were synthesized for sensing BTEX (benzene, toluene, ethylbenzene and xylene) vapours. The composites were characterized using atomic force microscopy (AFM) in an electroconductive mode. Gas sensing results show that EVA-CB can reproducibly detect BTEX and that the response increases linearly with vapour concentration. Compared to gas-sensing measurements of gasoline vapours, the responses with toluene and ethylbenzene are different and can be explained by varying side chains of the benzene ring...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28546752/essence-q-used-as-a-screening-tool-for-neurodevelopmental-problems-in-public-health-checkups-for-young-children-in-south-japan
#19
Yuhei Hatakenaka, Hitoshi Ninomiya, Eva Billstedt, Elisabeth Fernell, Christopher Gillberg
BACKGROUND: Screening for developmental disorders is an important task for Child Health Care. The concept of ESSENCE (early symptomatic syndromes eliciting neurodevelopmental clinical examinations) was created to cover all types of early developmental disorders and the ESSENCE-Questionnaire (ESSENCE-Q containing 12 questions with possible total scores ranging from 0 to 22) was developed as a tool for early detection of these disorders. The aim of this study was to perform a validation study in a public health situation in Japan...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28546645/fluorination-at-the-4-position-alters-the-substrate-behavior-of-l-glutamine-and-l-glutamate-implications-for-positron-emission-tomography-of-neoplasias
#20
Thomas M Jeitner, Eva Kristoferson, Juan A Azcona, John T Pinto, Clint Stalnecker, Jon W Erickson, Hank F Kung, Jianyong Li, Karl Ploessl, Arthur J L Cooper
Two 4-fluoro-L-glutamine diastereoisomers [(2S,4R)-4-FGln, (2S,4S)-4-FGln] were previously developed for positron emission tomography. Label uptake into two tumor cell types was greater with [(18)F](2S,4R)-4-FGln than with [(18)F](2S,4S)-4-FGln. In the present work we investigated the enzymology of two diastereoisomers of 4-FGln, two diastereoisomers of 4-fluoroglutamate (4-FGlu) (potential metabolites of the 4-FGln diastereoisomers) and another fluoro-derivative of L-glutamine [(2S,4S)-4-(3-fluoropropyl)glutamine (FP-Gln)]...
December 2016: Journal of Fluorine Chemistry
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