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https://www.readbyqxmd.com/read/29858985/predisposing-factors-to-heart-failure-in-diabetic-nephropathy-a-look-at-the-sympathetic-nervous-system-hyperactivity
#1
REVIEW
Klara Komici, Grazia Daniela Femminella, Claudio de Lucia, Alessandro Cannavo, Leonardo Bencivenga, Graziamaria Corbi, Dario Leosco, Nicola Ferrara, Giuseppe Rengo
Diabetes mellitus (DM) and heart failure (HF) are frequent comorbidities among elderly patients. HF, a leading cause of mortality and morbidity worldwide, is characterized by sympathetic nervous system hyperactivity. The prevalence of diabetes mellitus (DM) is rapidly growing and the risk of developing HF is higher among DM patients. DM is responsible for several macro- and micro-angiopathies that contribute to the development of coronary artery disease (CAD), peripheral artery disease, retinopathy, neuropathy and diabetic nephropathy (DN) as well...
June 1, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29767287/screening-for-comorbid-conditions-in-patients-enrolled-in-the-soda-registry-a-2-year-observational-analysis
#2
Whitney W Woodmansee, Murray B Gordon, Mark E Molitch, Adriana G Ioachimescu, Don W Carver, Beloo Mirakhur, David Cox, Roberto Salvatori
PURPOSE: This 2-year analysis assessed frequency of comorbidities and comorbidity screening in the Somatuline® (lanreotide, LAN) Depot for Acromegaly (SODA) registry. METHODS: Patient data collected included pituitary hormone deficiencies, sleep studies, echocardiograms, gallbladder sonographies, colonoscopies, and glycated hemoglobin (HbA1c) levels. Insulin-like growth factor-1 (IGF-1) and growth hormone levels in patients with (DM) and without (non-DM) diabetes mellitus were analyzed...
May 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29754174/targeting-mirna-for-therapy-of-juvenile-and-adult-diabetic-cardiomyopathy
#3
Shyam Sundar Nandi, Paras Kumar Mishra
Prevalence of diabetes mellitus (DM), a multifactorial disease often diagnosed with high blood glucose levels, is rapidly increasing in the world. Association of DM with multi-organ dysfunction including cardiomyopathy makes it a leading cause of morbidity and mortality. There are two major types of DM: type 1 DM (T1D) and type 2 DM (T2D). T1D is diagnosed by reduced levels of insulin and high levels of glucose in the blood. It is caused due to pancreatic beta cell destruction/loss, and mostly found in juveniles (juvenile DM)...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29731023/heart-failure-with-preserved-ejection-fraction-in-diabetes-mechanisms-and-management
#4
REVIEW
Patrick Meagher, Mohamed Adam, Robert Civitarese, Antoinette Bugyei-Twum, Kim A Connelly
Diabetes mellitus (DM) is a major cause of heart failure in the Western world, either secondary to coronary artery disease or from a distinct entity known as "diabetic cardiomyopathy." Furthermore, heart failure with preserved ejection fraction (HFpEF) is emerging as a significant clinical problem for patients with DM. Current clinical data suggest that between 30% and 40% of patients with HFpEF suffer from DM. The typical structural phenotype of the HFpEF heart consists of endothelial dysfunction, increased interstitial and perivascular fibrosis, cardiomyocyte stiffness, and hypertrophy along with advanced glycation end products deposition...
May 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29721501/resveratrol-prevents-diabetic-cardiomyopathy-by-increasing-nrf2-expression-and-transcriptional-activity
#5
Guan Wang, Xianjin Song, Lei Zhao, Zhibo Li, Bing Liu
Objective: This study investigated if resveratrol ameliorates diabetic cardiomyopathy by targeting associated oxidative stress mechanisms. Method: Type 1 diabetes mellitus (DM) in FVB mice was induced by several intraperitoneal injections of a low dose of streptozotocin. Hyperglycemic and age-matched control mice were given resveratrol (10 mg/kg per day) for 1 month and subsequently monitored for an additional 6 months. Mice were assigned to four groups: control, resveratrol, DM, and DM/resveratrol...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29686513/potential-role-of-cyanidin-3-glucoside-c3g-in-diabetic-cardiomyopathy-in-diabetic-rats-an-in-vivo-approach
#6
Weizhen Li, Songwen Chen, Genqing Zhou, Hongli Li, Lan Zhong, Shaowen Liu
The present study aimed to evaluate the importance of cyanidin 3-glucoside (C3G) of diabetic cardiomyopathy in diabetic rats. The rats were induced with diabetic using streptozotocin and total triglyceride (TG) and total cholesterol (TC) were determined. The range of myocardial enzymes such as aspartate aminotransferase (AST), creatine kinase (CK) and lactate dehydrogenase (LD) were also estimated, further, the Immuno histochemical analysis and western blot investigation were determined for the actual activity of C3G...
March 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29677191/type-2-diabetic-aldehyde-dehydrogenase-2-mutant-mice-aldh-2-2-exhibiting-heart-failure-with-preserved-ejection-fraction-phenotype-can-be-determined-by-exercise-stress-echocardiography
#7
Guodong Pan, Srikar Munukutla, Ananya Kar, Joseph Gardinier, Rajarajan A Thandavarayan, Suresh Selvaraj Palaniyandi
E487K point mutation of aldehyde dehydrogenase (ALDH) 2 (ALDH2*2) in East Asians intrinsically lowers ALDH2 activity. ALDH2*2 is associated with diabetic cardiomyopathy. Diabetic patients exhibit heart failure of preserved ejection fraction (HFpEF) i.e. while the systolic heart function is preserved in them, they may exhibit diastolic dysfunction, implying a jeopardized myocardial health. Currently, it is challenging to detect cardiac functional deterioration in diabetic mice. Stress echocardiography (echo) in the clinical set-up is a procedure used to measure cardiac reserve and impaired cardiac function in coronary artery diseases...
2018: PloS One
https://www.readbyqxmd.com/read/29659121/glucagon-like-peptide-1-ameliorates-cardiac-lipotoxicity-in-diabetic-cardiomyopathy-via-the-ppar%C3%AE-pathway
#8
Lujin Wu, Ke Wang, Wei Wang, Zheng Wen, Peihua Wang, Lei Liu, Dao Wen Wang
Lipotoxicity cardiomyopathy is the result of excessive accumulation and oxidation of toxic lipids in the heart. It is a major threat to patients with diabetes. Glucagon-like peptide-1 (GLP-1) has aroused considerable interest as a novel therapeutic target for diabetes mellitus because it stimulates insulin secretion. Here, we investigated the effects and mechanisms of the GLP-1 analog exendin-4 and the dipeptidyl peptidase-4 inhibitor saxagliptin on cardiac lipid metabolism in diabetic mice (DM). The increased myocardial lipid accumulation, oxidative stress, apoptosis, and cardiac remodeling and dysfunction induced in DM by low streptozotocin doses and high-fat diets were significantly reversed by exendin-4 and saxagliptin treatments for 8 weeks...
April 16, 2018: Aging Cell
https://www.readbyqxmd.com/read/29595686/risk-factors-and-outcomes-of-sepsis-induced-myocardial-dysfunction-and-stress-induced-cardiomyopathy-in-sepsis-or-septic-shock-a-comparative-retrospective-study
#9
COMPARATIVE STUDY
Han Saem Jeong, Tae Hyub Lee, Cho Hee Bang, Jong-Ho Kim, Soon Jun Hong
While both sepsis-induced myocardial dysfunction (SIMD) and stress-induced cardiomyopathy (SICMP) are common in patients with sepsis, the pathogenesis of the 2 diseases is different, and they require different treatment strategies. Thus, we aimed to investigate risk factors and outcomes between the 2 diseases.This retrospective study enrolled patients diagnosed with sepsis or septic shock, admitted to intensive care unit via emergency department in Korea University Anam Hospital, and who underwent transthoracic echocardiography within the first 24 hours of admission...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29571290/exercise-capacity-in-diabetes-mellitus-is-predicted-by-activity-status-and-cardiac-size-rather-than-cardiac-function-a-case-control-study
#10
Timothy J Roberts, Andrew T Burns, Richard J MacIsaac, Andrew I MacIsaac, David L Prior, André La Gerche
BACKGROUND: The reasons for reduced exercise capacity in diabetes mellitus (DM) remains incompletely understood, although diastolic dysfunction and diabetic cardiomyopathy are often favored explanations. However, there is a paucity of literature detailing cardiac function and reserve during incremental exercise to evaluate its significance and contribution. We sought to determine associations between comprehensive measures of cardiac function during exercise and maximal oxygen consumption ([Formula: see text]peak), with the hypothesis that the reduction in exercise capacity and cardiac function would be associated with co-morbidities and sedentary behavior rather than diabetes itself...
March 23, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29568331/impact-of-diabetes-mellitus-on-ischemic-cardiomyopathy-five-year-follow-up-revision-dm-trial
#11
Thiago Hueb, Mauricio S Rocha, Sergio F Siqueira, Silvana Angelina D Orio Nishioka, Giselle L Peixoto, Marcos M Saccab, Eduardo Gomes Lima, Rosa Maria Rahmi Garcia, José Antonio F Ramires, Roberto Kalil Filho, Martino Martinelli Filho
Background: Patients with ischemic cardiomyopathy and severe left ventricular dysfunction have a worse survival prognosis than patients with preserved ventricular function. The role of diabetes in the long-term prognosis of this patient group is unknown. This study investigated whether the presence of diabetes has a long-term impact on left ventricular function. Methods: Patients with coronary artery disease who underwent coronary artery bypass graft surgery, percutaneous coronary intervention, or medical therapy alone were included...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29541610/echocardiographic-feature-of-diabetic-cardiomyopathy-where-are-we-now
#12
REVIEW
Kazuaki Negishi
We are now entering the very exciting era of treatment and management of diabetes mellitus (DM) with the emergence of new therapeutic agents, including sodium-glucose cotransporter 2 inhibitors (SGLT2i) and dipeptidyl peptidase-4 inhibitor (DPP-4i). From a cardiology and echocardiography perspective, the existence of diabetic cardiomyopathy has been proven through over four decades of discussion. DM is highly prevalent in patients with heart failure (HF). Independent associations are found after adjusting for hypertension (HTN) and coronary artery disease (CAD)...
February 2018: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29482192/type-i-diabetic-akita-mouse-model-is-characterized-by-abnormal-cardiac-deformation-during-early-stages-of-diabetic-cardiomyopathy-with-speckle-tracking-based-strain-imaging
#13
Yingchao Zhou, Hong Xiao, Jianfei Wu, Lingfeng Zha, Mengchen Zhou, Qianqian Li, Mengru Wang, Shumei Shi, Yanze Li, Liangkun Lyu, Qing Wang, Xin Tu, Qiulun Lu
BACKGROUND/AIMS: Diabetes mellitus (DM) has been demonstrated to have a strong association with heart failure. Conventional echocardiographic analysis cannot sensitively monitor cardiac dysfunction in type I diabetic Akita hearts, but the phenotype of heart failure is observed in molecular levels during the early stages. METHODS: Male Akita (Ins2WT/C96Y) mice were monitored with echocardiographic imaging at various ages, and then with conventional echocardiographic analysis and speckle-tracking based strain analyses...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29471918/pathophysiology-and-prevention-of-heart-disease-in-diabetes-mellitus
#14
Ahmet Afşin Oktay, Halis Kaan Akturk, Kerim Esenboğa, Fahad Javed, Nichole M Polin, Eiman Jahangir
Diabetes mellitus (DM) has become a public health problem worldwide, and it has large implications for cardiovascular disease (CVD). In this article, we discuss the etiology and pathophysiology of CVD in DM including the effects of abnormal glucose homeostasis, genetic factors, epigenetics, apoptosis, common pathophysiological mechanisms shared by both DM and CVD, and contributions of other comorbidities. We then cover the pathogenesis of both atherosclerotic disease and cardiomyopathy in relation to DM. Finally, we discuss the prevention of heart disease in DM with a focus on hypertension and dyslipidemia management, weight loss, lifestyle changes, antiplatelet therapy, and glycemic control...
March 2018: Current Problems in Cardiology
https://www.readbyqxmd.com/read/29462717/evaluating-the-impact-of-diabetes-and-diabetic-cardiomyopathy-rat-heart-on-the-outcome-of-ischemia-reperfusion-associated-oxidative-stress
#15
A Mahalakshmi, Gino A Kurian
Earlier literature underlines that oxidative stress plays a major role in the pathology of myocardial ischemia-reperfusion (I/R) injury, diabetic cardiomyopathy (DCM), diabetes mellitus (DM), fibrosis and hypertrophy which could adversely affect the normal cardiac function. However, the contributory role of oxidative stress in I/R pathology of heart with pre-existing abnormalities or diseases like DM and DCM remains to be explored. I/R injury was induced in normal (normal diet), DM (normal diet + streptozotocin: multiple low dose of 30 mg/kg) and DCM (high fat diet (40% fat) + streptozotocin: multiple low dose of 30 mg/kg) rat hearts using Langendorff isolated heart perfusion apparatus...
April 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29421917/a-dieulafoy-s-lesion-in-a-duodenal-diverticulum-an-infrequent-cause-of-ugib
#16
Marina de Benito Sanz, Marta Cimavilla Román, Raúl Torres Yuste
We present the case of an 82-year-old man with a history of heart failure, mitral regurgitation, type 2 DM, hypertension, dilated cardiomyopathy and a paroxysmal atrial flutter. The patient was under treatment with Sintrom. The patient presented to the emergency department due to melenic depositions of a one day evolution and dietary vomiting. There was no rectal bleeding and the patient was admitted three months previously due to self-limited melena with a normal gastroscopy. Anemia of 8 g and an overdose of Sintrom was diagnosed...
April 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29387042/type-2-diabetes-mellitus-and-cardiovascular-disease-genetic-and-epigenetic-links
#17
REVIEW
Salvatore De Rosa, Biagio Arcidiacono, Eusebio Chiefari, Antonio Brunetti, Ciro Indolfi, Daniela P Foti
Type 2 diabetes mellitus (DM) is a common metabolic disorder predisposing to diabetic cardiomyopathy and atherosclerotic cardiovascular disease (CVD), which could lead to heart failure through a variety of mechanisms, including myocardial infarction and chronic pressure overload. Pathogenetic mechanisms, mainly linked to hyperglycemia and chronic sustained hyperinsulinemia, include changes in metabolic profiles, intracellular signaling pathways, energy production, redox status, increased susceptibility to ischemia, and extracellular matrix remodeling...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29343259/influence-of-apocynin-on-cardiac-remodeling-in-rats-with-streptozotocin-induced-diabetes-mellitus
#18
R Gimenes, C Gimenes, C M Rosa, N P Xavier, D H S Campos, A A H Fernandes, M D M Cezar, G N Guirado, L U Pagan, I D Chaer, D C Fernandes, F R Laurindo, A C Cicogna, M P Okoshi, K Okoshi
BACKGROUND: Increased reactive oxygen species (ROS) generation in diabetes mellitus (DM) is an important mechanism leading to diabetic cardiomyopathy. Apocynin, a drug isolated from the herb Picrorhiza kurroa, is considered an antioxidant agent by inhibiting NADPH oxidase activity and improving ROS scavenging. This study analyzed the influence of apocynin on cardiac remodeling in diabetic rats. METHODS: Six-month-old male Wistar rats were assigned into 4 groups: control (CTL, n = 15), control + apocynin (CTL + APO, n = 20), diabetes (DM, n = 20), and diabetes + apocynin (DM + APO, n = 20)...
January 17, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29322879/puerarin-prevents-diabetic-cardiomyopathy-in-vivo-and-in-vitro-by-inhibition-of-inflammation
#19
Mao-Shan Yin, Yi-Chi Zhang, Shu-Hong Xu, Jing-Jing Liu, Xiao-Hui Sun, Chen Liang, Yan Wang, Jie Li, Fu-Wen Wang, Qing-Li Wang, Yan-Ling Mu
Diabetic cardiomyopathy (DCM) is one of the chief diabetes mellitus complications. Inflammation factors may be one reason for the damage from DM. The purpose of this research is to study the potential protective effects of puerarin on DM and the possible mechanisms of action related to NF-κB signal pathway. Following administration of puerarin to the disease model rat, several changes were observed including the changes of serum biochemical index, improved diastolic dysfunction, and enhanced endogenous antioxidant enzymes activities, further NF-κB signaling activation...
January 11, 2018: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29284577/distinct-myocardial-targets-for-diabetes-therapy-in-heart-failure-with-preserved-or-reduced-ejection-fraction
#20
REVIEW
Walter J Paulus, Elisa Dal Canto
Noncardiac comorbidities such as diabetes mellitus (DM) have different outcomes in heart failure with preserved ejection fraction (HFpEF) compared with heart failure with reduced ejection fraction (HFrEF). These different outcomes are the result of distinct myocardial effects of DM on HFpEF and HFrEF, which relate to different mechanisms driving myocardial remodeling in each heart failure phenotype. Myocardial remodeling is driven by microvascular endothelial inflammation in HFpEF and by cardiomyocyte cell death in HFrEF...
January 2018: JACC. Heart Failure
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