keyword
https://read.qxmd.com/read/38522816/targeting-rock2-improves-macromolecular-permeability-in-a-3d-fibrotic-pancreatic-cancer-microenvironment-model
#21
JOURNAL ARTICLE
Hiroyoshi Y Tanaka, Takuya Nakazawa, Takuya Miyazaki, Horacio Cabral, Atsushi Masamune, Mitsunobu R Kano
Pancreatic cancer is characterized by a densely fibrotic stroma. The fibrotic stroma hinders the intratumoral penetration of nanomedicine and diminishes therapeutic efficacy. Fibrosis is characterized by an abnormal organization of extracellular matrix (ECM) components, namely the abnormal deposition and/or orientation of collagen and fibronectin. Abnormal ECM organization is chiefly driven by pathological signaling in pancreatic stellate cells (PSCs), the main cell type involved in fibrogenesis. However, whether targeting signaling pathways involved in abnormal ECM organization improves the intratumoral penetration of nanomedicines is unknown...
March 22, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38521973/immunohistochemical-staining-with-cd117-and-pgp9-5-of-excised-vestibular-tissue-from-patients-with-neuroproliferative-vestibulodynia
#22
JOURNAL ARTICLE
Alexandra Drian, Sue W Goldstein, Noel N Kim, Andrew S Goldstein, Rose Hartzell-Cushanick, Alyssa Yee, Irwin Goldstein
BACKGROUND: Neuroproliferative vestibulodynia (NPV), a provoked genital pain characterized by severe allodynia and hyperalgesia, is confirmed in excised vestibular tissue by immunohistochemical staining (>8 CD117-positive immunostained cells/100× microscopic field) rather than by hematoxylin and eosin staining. AIM: In this study we sought to assess immunostaining of tissue samples obtained during vestibulectomy surgery and to correlate results with patient outcomes...
March 23, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38521965/emerging-measurements-for-tumor-infiltrating-lymphocytes-in-breast-cancer
#23
JOURNAL ARTICLE
Rongrong Wu, Yoshiya Horimoto, Masanori Oshi, Matthew G K Benesch, Thaer Khoury, Kazuaki Takabe, Takashi Ishikawa
Tumor-infiltrating lymphocytes are a general term for lymphocytes or immune cells infiltrating the tumor microenvironment. Numerous studies have demonstrated tumor-infiltrating lymphocytes to be robust prognostic and predictive biomarkers in breast cancer. Recently, immune checkpoint inhibitors, which directly target tumor-infiltrating lymphocytes, have become part of standard of care treatment for triple-negative breast cancer. Surprisingly, tumor-infiltrating lymphocytes quantified by conventional methods do not predict response to immune checkpoint inhibitors, which highlights the heterogeneity of tumor-infiltrating lymphocytes and the complexity of the immune network in the tumor microenvironment...
March 23, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38521346/severe-epithelial-ingrowth-after-pars-plana-vitrectomy-ten-years-after-lasik-relifting
#24
José Ignacio Fernández-Vigo, Ana Macarro-Merino, Barbara Burgos-Blasco, Ignacio Almorín-Fernández-Vigo, Pedro Arriola-Villalobos, José Ángel Fernández-Vigo Professo
Epithelial ingrowth is one of the most significant complications of Laser in Situ Keratomileusis (LASIK) refractive surgery. We present the case of a 72-year-old male with a history of myopic LASIK (1999), who underwent cataract surgery and a second thin LASIK sub-Bowman flap to correct refractive error. Then, three months after pars plana vitrectomy for an epiretinal membrane, the patient complained of progressive vision loss. A diffuse haze of the corneal stroma that did not exist before surgery was observed...
March 21, 2024: Archivos de la Sociedad Española de Oftalmología
https://read.qxmd.com/read/38520912/development-of-a-novel-prostate-cancer-stroma-sphere-css-model-for-in-vitro-tumor-microenvironment-studies
#25
JOURNAL ARTICLE
Aigul R Rakhmatullina, Maria A Zolotykh, Yulia V Filina, Rimma N Mingaleeva, Aisylu R Sagdeeva, Eugenia A Boulygina, Dina U Gafurbaeva, Emil R Bulatov, Albert A Rizvanov, Regina R Miftakhova
Tumor employs non-cancerous cells to gain beneficial features that promote growth and survival of cancer cells. Despite intensive research in the area of tumor microenvironment, there is still a lack of reliable and reproducible in vitro model for tumor and tumor-microenvironment cell interaction studies. Herein we report the successful development of a heterogeneous cancer-stroma sphere (CSS) model composed of prostate adenocarcinoma PC3 cells and immortalized mesenchymal stem cells (MSC). The CSS model demonstrated a structured spatial layout of the cells, with stromal cells concentrated at the center of the spheres and tumor cells located on the periphery...
March 22, 2024: Translational Oncology
https://read.qxmd.com/read/38520823/editorial-overview-tumor-stroma-crosstalk-shaping-and-characterizing-the-metabolic-microenvironment-of-tumors
#26
EDITORIAL
Seth Parker, Thekla Cordes
No abstract text is available yet for this article.
March 22, 2024: Current Opinion in Biotechnology
https://read.qxmd.com/read/38520120/fatal-septicemia-in-2-south-american-camelids-with-caudal-c3-pyloric-duodenal-adenocarcinoma
#27
JOURNAL ARTICLE
Clemer Abad, Heather Fritz, Omar Gonzales-Viera
Gastrointestinal adenocarcinomas are often reported in South American camelids (SAC). We describe here cases of gastroduodenal adenocarcinoma in an adult alpaca ( Vicugna pacos ) and a llama ( Llama glama ); both SACs were anorectic and lethargic before death. At autopsy, a prominent and firm caudal C3-pyloric-duodenal junction with stricture and ulceration was present in both animals, as were hemorrhages in various organs and hydrothorax. Microscopically, scattered nests, cords, and tortuous acini of neoplastic epithelial cells were embedded in desmoplastic stroma and invaded the submucosa and muscle layers of the gastroduodenal junction...
March 23, 2024: Journal of Veterinary Diagnostic Investigation
https://read.qxmd.com/read/38519754/investigating-morphological-changes-in-a-simple-mucinous-cyst-during-the-follow-up-period-a-case-report
#28
JOURNAL ARTICLE
Tatsunori Satoh, Shinya Kawaguchi, Chinatsu Tsuchikabe, Hideyuki Kanemoto
A 64-year-old man was referred to our department after a small pancreatic cystic lesion was discovered on computed tomography performed to assess choledocholithiasis. Multiple standard imaging modalities, including endoscopic ultrasound (EUS), failed to reveal pancreatic masses, wall thickening, or mural nodules. Consequently, a benign pancreatic cystic lesion was suspected, and the patient underwent biannual imaging studies including rotating magnetic resonance imaging and EUS. Six years after the initial detection of the pancreatic cyst, wall thickening was observed, leading to a shortened observation period of once every 3 months...
March 22, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38519058/digital-spatial-proteomic-profiling-reveals-immune-checkpoints-as-biomarkers-in-lymphoid-aggregates-and-tumor-microenvironment-of-desmoplastic-melanoma
#29
JOURNAL ARTICLE
David G Su, David A Schoenfeld, Wael Ibrahim, Raysa Cabrejo, Dijana Djureinovic, Raymond Baumann, David L Rimm, Sajid A Khan, Ruth Halaban, Harriet M Kluger, Kelly Olino, Anjela Galan, James Clune
BACKGROUND: Desmoplastic melanoma (DM) is a rare melanoma subtype characterized by dense fibrous stroma, a propensity for local recurrence, and a high response rate to programmed cell death protein 1 (PD-1) blockade. Occult sentinel lymph node positivity is significantly lower in both pure and mixed DM than in conventional melanoma, underscoring the need for better prognostic biomarkers to inform therapeutic strategies. METHODS: We assembled a tissue microarray comprising various cores of tumor, stroma, and lymphoid aggregates from 45 patients with histologically confirmed DM diagnosed between 1989 and 2018...
March 21, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38517430/primary-cilium-in-neural-crest-cells-crucial-for-anterior-segment-development-and-corneal-avascularity
#30
JOURNAL ARTICLE
Seungwoon Seo, Seong Keun Sonn, Hyae Yon Kweon, Jing Jin, Tsutomu Kume, Je Yeong Ko, Jong Hoon Park, Goo Taeg Oh
PURPOSE: Intraflagellar transport 46 (IFT46) is an integral subunit of the IFT-B complex, playing a key role in the assembly and maintenance of primary cilia responsible for transducing signaling pathways. Despite its predominant expression in the basal body of cilia, the precise role of Ift46 in ocular development remains undetermined. This study aimed to elucidate the impact of neural crest (NC)-specific deletion of Ift46 on ocular development. METHODS: NC-specific conditional knockout mice for Ift46 (NC-Ift46F/F) were generated by crossing Ift46F mice with Wnt1-Cre2 mice, enabling the specific deletion of Ift46 in NC-derived cells (NCCs)...
March 5, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38517106/spindle-cell-neoplasms-with-novel-ltk-fusion-expanding-the-spectrum-of-kinase-fusion-positive-soft-tissue-tumors
#31
JOURNAL ARTICLE
Maximus C F Yeung, Josephine K Dermawan, Anthony P Y Liu, Albert Y L Lam, Cristina R Antonescu, Tony W H Shek
AIMS: Kinase fusion-positive soft tissue tumors represent an emerging, molecularly defined group of mesenchymal tumors with a wide morphologic spectrum and diverse activating kinases. Here, we present two cases of soft tissue tumors with novel LTK fusions. METHODS AND RESULTS: Both cases presented as acral skin nodules (big toe and middle finger) in pediatric patients (17-year-old girl and 2-year-old boy). The tumors measured 2 and 3 cm in greatest dimension...
March 2024: Genes, Chromosomes & Cancer
https://read.qxmd.com/read/38516389/investigation-of-topical-amniotic-membrane-suspension-and-regenerating-agent-on-early-corneal-stromal-healing-in-rats
#32
JOURNAL ARTICLE
Hao Lee, Wei-Hsiang Huang, Yi-Chen Sun, Chung-Tien Lin
Innovative topical bioregenerative materials promoting corneal stromal healing provide valuable alternatives for treating patients with deep corneal ulcers, and particularly beneficial for those with a higher anaesthetic risk. This study aimed to investigate the effects of topical amniotic membrane suspension (AMS) and ReGeneraTing Agent (RGTA) on surgically induced deep stromal ulcers in rats. Eighteen Sprague-Dawley rats were divided into 3 treatment groups: control group (topical normal saline, TID); AMS group (topical AMS, TID); RGTA group (topical RGTA, Q2D)...
June 2024: Veterinary and Animal Science
https://read.qxmd.com/read/38515569/cytotoxic-response-of-tumor-infiltrating-lymphocytes-of-head-and-neck-cancer-slice-cultures-under-mitochondrial-dysfunction
#33
JOURNAL ARTICLE
Maria do Carmo Greier, Annette Runge, Jozsef Dudas, Roland Hartl, Matthias Santer, Daniel Dejaco, Teresa Bernadette Steinbichler, Julia Federspiel, Christof Seifarth, Marko Konschake, Susanne Sprung, Sieghart Sopper, Avneet Randhawa, Melissa Mayr, Benedikt Gabriel Hofauer, Herbert Riechelmann
BACKGROUND: Head and neck squamous cell carcinomas (HNSCC) are highly heterogeneous tumors. In the harsh tumor microenvironment (TME), metabolic reprogramming and mitochondrial dysfunction may lead to immunosuppressive phenotypes. Aerobic glycolysis is needed for the activation of cytotoxic T-cells and the absence of glucose may hamper the full effector functions of cytotoxic T-cells. To test the effect of mitochondrial dysfunction on cytotoxic T cell function, slice cultures (SC) of HNSCC cancer were cultivated under different metabolic conditions...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38515339/-staphylococcus-pseudintermedius-induces-pyroptosis-of-canine-corneal-epithelial-cells-by-activating-the-ros-nlrp3-signaling-pathway
#34
JOURNAL ARTICLE
Zhihao Wang, Long Guo, Changning Yuan, Chengcheng Zhu, Jun Li, Haoran Zhong, Peng Mao, Jianji Li, Luying Cui, Junsheng Dong, Kangjun Liu, Xia Meng, Guoqiang Zhu, Heng Wang
Staphylococcus pseudintermedius ( S. pseudintermedius ) is a common pathogen that causes canine corneal ulcers. However, the pathogenesis remained unclear. In this study, it has been demonstrated that S. pseudintermedius invaded canine corneal epithelial cells (CCECs) intracellularly, mediating oxidative damage and pyroptosis by promoting the accumulation of intracellular reactive oxygen species (ROS) and activating the NLRP3 inflammasome. The canine corneal stroma was infected with S. pseudintermedius to establish the canine corneal ulcer model in vivo...
March 22, 2024: Virulence
https://read.qxmd.com/read/38513048/cornea-specific-human-adipose-stem-cell-derived-extracellular-matrix-for-corneal-stroma-tissue-engineering
#35
JOURNAL ARTICLE
Paula Puistola, Abhinav Kethiri, Antti Nurminen, Johannes Turkki, Karoliina Hopia, Susanna Miettinen, Anni Mörö, Heli Skottman
Utilizing tissue-specific extracellular matrices (ECMs) is vital for replicating the composition of native tissues and developing biologically relevant biomaterials. Human- or animal-derived donor tissues and organs are the current gold standard for the source of these ECMs. To overcome the several limitations related to these ECM sources, including the highly limited availability of donor tissues, cell-derived ECM offers an alternative approach for engineering tissue-specific biomaterials, such as bioinks for three-dimensional (3D) bioprinting...
March 21, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38512284/choroidal-vascularity-index-and-choroidal-structural-changes-in-children-with-nephrotic-syndrome
#36
JOURNAL ARTICLE
Wenbo Zhang, Junmeng Li, Lei Zhu, Shuang Zeng, Yanye Lu, Yadi Zhang, Xiaopeng Gu, Hailong Wu, Liu Yang
PURPOSE: To investigate the choroidal vascularity index (CVI) and choroidal structural changes in children with nephrotic syndrome. METHODS: This was a cross-sectional study involving 45 children with primary nephrotic syndrome and 40 normal controls. All participants underwent enhanced depth imaging-optical coherence tomography examinations. An automatic segmentation method based on deep learning was used to segment the choroidal vessels and stroma, and the choroidal volume (CV), vascular volume (VV), and CVI within a 4...
March 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38511230/translocator-protein%C3%A2-expression-and-localization-in-human-endometrium-and-endometriosis-a-potential-target-for-a-noninvasive-diagnosis
#37
JOURNAL ARTICLE
Maíra Casalechi, Cynthia Dela Cruz, Wiviane A Assis, Millene Vieira-Lopes, Felipe Eduardo F Lopes, Antônio M C Francisco, Fernando M Reis
The limitations of current imaging methods to detect small or superficial endometriotic lesions prompt the search for new molecular targets. TSPO is an 18 KDa protein located in the outer mitochondrial membrane, which can be traced by positron emission tomography (PET) using specific ligands. TSPO is located mostly in neurons and inflammatory sites outside the brain. We hypothesized that it might also be expressed in the human endometrium and endometrial-like tissue, being a target for molecular imaging of endometriosis...
March 21, 2024: Cell Biology International
https://read.qxmd.com/read/38511208/the-impact-of-ovarian-stimulation-on-the-human-endometrial-microenvironment
#38
JOURNAL ARTICLE
Anat Chemerinski, May Shen, Nuriban Valero-Pacheco, Qingshi Zhao, Trystn Murphy, Lea George, Alex Lemenze, Lauren Sherman, Debra Heller, Xiaowei Chen, Tracy Wu, Peter G McGovern, Sara S Morelli, Ripla Arora, Aimee M Beaulieu, Nataki C Douglas
STUDY QUESTION: How does ovarian stimulation (OS), which is used to mature multiple oocytes for ART procedures, impact the principal cellular compartments and transcriptome of the human endometrium in the periovulatory and mid-secretory phases? SUMMARY ANSWER: During the mid-secretory window of implantation, OS alters the abundance of endometrial immune cells, whereas during the periovulatory period, OS substantially changes the endometrial transcriptome and impacts both endometrial glandular and immune cells...
March 20, 2024: Human Reproduction
https://read.qxmd.com/read/38511025/desmoplastic-melanoma-of-the-chest-wall-a-diagnostic-dilemma
#39
Adil Aziz Khan, Sufian Zaheer, Parth Gulati, Sana Ahuja
Desmoplastic melanoma is an extremely rare subtype of malignant melanoma comprising only 1% of all the cutaneous melanomas. Being amelanotic and owing to its histopathological features of spindle cells lying in a collagenized stroma, it is often misdiagnosed as a dermatofibroma or scar tissue. The present case study describes a case of desmoplastic melanoma of the chest wall where the final diagnosis could be arrived at only after an extensive immunohistochemical panel to exclude other spindle cell proliferations...
March 2024: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/38511017/cytodiagnostic-dilemma-in-a-lung-mass-as-the-first-presentation-of-testicular-mixed-germ-cell-tumor-metastasis
#40
Cherry Bansal, Amanpreet Singh, Dimple Kapoor, Charu Nayyar, Mohammed Nadeem Shaikh, P C Swami
Testicular mixed germ cell tumors (TMGCTs) are rare malignant tumors comprising of two or more types of germ cell tumors. Their onset may be undetectable and the patient may first present with symptoms of metastasis. We hereby report a case of a young male who presented with respiratory discomfort and had no symptoms of primary testicular tumor. CT-guided FNAC lung revealed mainly necrotic, keratinous debris with a focus of chondromyxoid stroma. Differential diagnoses of components of teratoma, squamous cell carcinoma and inclusion cyst was considered...
March 2024: Indian Journal of Surgical Oncology
keyword
keyword
38100
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.